From 6476f5f49b373cd4cf05f2e73389df83e437d597 Mon Sep 17 00:00:00 2001 From: Johannes Ranke Date: Thu, 13 Feb 2025 16:30:31 +0100 Subject: Axis legend formatting, update vignettes --- docs/dev/reference/AIC.mmkin.html | 220 - docs/dev/reference/CAKE_export.html | 225 - docs/dev/reference/D24_2014.html | 261 - docs/dev/reference/DFOP.solution-1.png | Bin 31964 -> 0 bytes docs/dev/reference/DFOP.solution.html | 202 - docs/dev/reference/Extract.mmkin.html | 235 - docs/dev/reference/FOCUS_2006_DFOP_ref_A_to_B.html | 189 - docs/dev/reference/FOCUS_2006_FOMC_ref_A_to_F.html | 186 - docs/dev/reference/FOCUS_2006_HS_ref_A_to_F.html | 189 - docs/dev/reference/FOCUS_2006_SFO_ref_A_to_F.html | 183 - docs/dev/reference/FOCUS_2006_datasets.html | 181 - docs/dev/reference/FOMC.solution-1.png | Bin 29520 -> 0 bytes docs/dev/reference/FOMC.solution.html | 213 - docs/dev/reference/HS.solution-1.png | Bin 29572 -> 0 bytes docs/dev/reference/HS.solution.html | 203 - docs/dev/reference/IORE.solution-1.png 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the AIC for a column of an mmkin object — AIC.mmkin • mkin - - -
-
- - - -
-
-
-

Calculate the AIC for a column of an mmkin object

- Source: R/AIC.mmkin.R - -
- -
-

Provides a convenient way to compare different kinetic models fitted to the -same dataset.

-
- -
- 
# S3 method for mmkin
-AIC(object, ..., k = 2)
-
-# S3 method for mmkin
-BIC(object, ...)
-
- -
-

Arguments

-
object
-

An object of class mmkin, containing only one -column.

- - -
...
-

For compatibility with the generic method

- - -
k
-

As in the generic method

- -
-
-

Value

- - -

As in the generic method (a numeric value for single fits, or a -dataframe if there are several fits in the column).

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-   # skip, as it takes > 10 s on winbuilder
-  f <- mmkin(c("SFO", "FOMC", "DFOP"),
-    list("FOCUS A" = FOCUS_2006_A,
-         "FOCUS C" = FOCUS_2006_C), cores = 1, quiet = TRUE)
-  # We get a warning because the FOMC model does not converge for the
-  # FOCUS A dataset, as it is well described by SFO
-
-  AIC(f["SFO", "FOCUS A"]) # We get a single number for a single fit
-#> [1] 55.28197
-  AIC(f[["SFO", "FOCUS A"]]) # or when extracting an mkinfit object
-#> [1] 55.28197
-
-  # For FOCUS A, the models fit almost equally well, so the higher the number
-  # of parameters, the higher (worse) the AIC
-  AIC(f[, "FOCUS A"])
-#>      df      AIC
-#> SFO   3 55.28197
-#> FOMC  4 57.28222
-#> DFOP  5 59.28197
-  AIC(f[, "FOCUS A"], k = 0) # If we do not penalize additional parameters, we get nearly the same
-#>      df      AIC
-#> SFO   3 49.28197
-#> FOMC  4 49.28222
-#> DFOP  5 49.28197
-  BIC(f[, "FOCUS A"])        # Comparing the BIC gives a very similar picture
-#>      df      BIC
-#> SFO   3 55.52030
-#> FOMC  4 57.59999
-#> DFOP  5 59.67918
-
-  # For FOCUS C, the more complex models fit better
-  AIC(f[, "FOCUS C"])
-#>      df      AIC
-#> SFO   3 59.29336
-#> FOMC  4 44.68652
-#> DFOP  5 29.02372
-  BIC(f[, "FOCUS C"])
-#>      df      BIC
-#> SFO   3 59.88504
-#> FOMC  4 45.47542
-#> DFOP  5 30.00984
-  
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/CAKE_export.html b/docs/dev/reference/CAKE_export.html deleted file mode 100644 index 7b52a8c5..00000000 --- a/docs/dev/reference/CAKE_export.html +++ /dev/null @@ -1,225 +0,0 @@ - -Export a list of datasets format to a CAKE study file — CAKE_export • mkin - - -
-
- - - -
-
-
-

Export a list of datasets format to a CAKE study file

- Source: R/CAKE_export.R - -
- -
-

In addition to the datasets, the pathways in the degradation model can be -specified as well.

-
- -
- 
CAKE_export(
-  ds,
-  map = c(parent = "Parent"),
-  links = NA,
-  filename = "CAKE_export.csf",
-  path = ".",
-  overwrite = FALSE,
-  study = "Degradinol aerobic soil degradation",
-  description = "",
-  time_unit = "days",
-  res_unit = "% AR",
-  comment = "",
-  date = Sys.Date(),
-  optimiser = "IRLS"
-)
-
- -
-

Arguments

-
ds
-

A named list of datasets in long format as compatible with -mkinfit.

- - -
map
-

A character vector with CAKE compartment names (Parent, A1, ...), -named with the names used in the list of datasets.

- - -
links
-

An optional character vector of target compartments, named with -the names of the source compartments. In order to make this easier, the -names are used as in the datasets supplied.

- - -
filename
-

Where to write the result. Should end in .csf in order to be -compatible with CAKE.

- - -
path
-

An optional path to the output file.

- - -
overwrite
-

If TRUE, existing files are overwritten.

- - -
study
-

The name of the study.

- - -
description
-

An optional description.

- - -
time_unit
-

The time unit for the residue data.

- - -
res_unit
-

The unit used for the residues.

- - -
comment
-

An optional comment.

- - -
date
-

The date of file creation.

- - -
optimiser
-

Can be OLS or IRLS.

- -
-
-

Value

- - -

The function is called for its side effect.

-
-
-

Author

-

Johannes Ranke

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/D24_2014.html b/docs/dev/reference/D24_2014.html deleted file mode 100644 index 8af0a8e2..00000000 --- a/docs/dev/reference/D24_2014.html +++ /dev/null @@ -1,261 +0,0 @@ - -Aerobic soil degradation data on 2,4-D from the EU assessment in 2014 — D24_2014 • mkin - - -
-
- - - -
-
-
-

Aerobic soil degradation data on 2,4-D from the EU assessment in 2014

- Source: R/D24_2014.R - -
- -
-

The five datasets were extracted from the active substance evaluation dossier -published by EFSA. Kinetic evaluations shown for these datasets are intended -to illustrate and advance kinetic modelling. The fact that these data and -some results are shown here does not imply a license to use them in the -context of pesticide registrations, as the use of the data may be -constrained by data protection regulations.

-
- -
- 
D24_2014
-
- -
-

Format

-

An mkindsg object grouping five datasets

-
-
-

Source

-

Hellenic Ministry of Rural Development and Agriculture (2014) -Final addendum to the Renewal Assessment Report - public version - 2,4-D -Volume 3 Annex B.8 Fate and behaviour in the environment -https://open.efsa.europa.eu/study-inventory/EFSA-Q-2013-00811

-
-
-

Details

-

Data for the first dataset are from p. 685. Data for the other four -datasets were used in the preprocessed versions given in the kinetics -section (p. 761ff.), with the exception of residues smaller than 1 for DCP -in the soil from Site I2, where the values given on p. 694 were used.

-

The R code used to create this data object is installed with this package -in the 'dataset_generation' directory. In the code, page numbers are given for -specific pieces of information in the comments.

-
- -
-

Examples

- 
print(D24_2014)
-#> <mkindsg> holding 5 mkinds objects
-#> Title $title:  Aerobic soil degradation data on 2,4-D from the EU assessment in 2014 
-#> Occurrence of observed compounds $observed_n:
-#> D24 DCP DCA 
-#>   5   4   4 
-#> Time normalisation factors $f_time_norm:
-#> [1] 1.6062378 0.7118732 0.7156063 0.7156063 0.8977124
-#> Meta information $meta:
-#>                                 study usda_soil_type study_moisture_ref_type
-#> Mississippi                Cohen 1991      Silt loam                    <NA>
-#> Fayette     Liu and Adelfinskaya 2011      Silt loam                     pF1
-#> RefSol 03-G Liu and Adelfinskaya 2011           Loam                     pF1
-#> Site E1     Liu and Adelfinskaya 2011           Loam                     pF1
-#> Site I2     Liu and Adelfinskaya 2011     Loamy sand                     pF1
-#>             rel_moisture temperature
-#> Mississippi           NA          25
-#> Fayette              0.5          20
-#> RefSol 03-G          0.5          20
-#> Site E1              0.5          20
-#> Site I2              0.5          20
-# \dontrun{
-print(D24_2014$ds[[1]], data = TRUE)
-#> <mkinds> with $title:  Mississippi 
-#> Observed compounds $observed:  D24 
-#> Sampling times $sampling_times:
-#> 0, 2, 4, 7, 15, 24, 35, 56, 71, 114, 183, 273, 365 
-#> With a maximum of  1  replicates
-#>    time  D24
-#> 1     0 96.8
-#> 2     2 81.0
-#> 3     4 81.7
-#> 4     7 88.2
-#> 5    15 66.3
-#> 6    24 72.9
-#> 7    35 62.6
-#> 8    56 54.6
-#> 9    71 35.2
-#> 10  114 18.0
-#> 11  183 11.3
-#> 12  273  9.9
-#> 13  365  6.3
-m_D24 = mkinmod(D24 = mkinsub("SFO", to = "DCP"),
-  DCP = mkinsub("SFO", to = "DCA"),
-  DCA = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-print(m_D24)
-#> <mkinmod> model generated with
-#> Use of formation fractions $use_of_ff: max 
-#> Specification $spec:
-#> $D24
-#> $type: SFO; $to: DCP; $sink: TRUE
-#> $DCP
-#> $type: SFO; $to: DCA; $sink: TRUE
-#> $DCA
-#> $type: SFO; $sink: TRUE
-#> Coefficient matrix $coefmat available
-#> Compiled model $cf available
-#> Differential equations:
-#> d_D24/dt = - k_D24 * D24
-#> d_DCP/dt = + f_D24_to_DCP * k_D24 * D24 - k_DCP * DCP
-#> d_DCA/dt = + f_DCP_to_DCA * k_DCP * DCP - k_DCA * DCA
-m_D24_2 = mkinmod(D24 = mkinsub("DFOP", to = "DCP"),
-  DCP = mkinsub("SFO", to = "DCA"),
-  DCA = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-print(m_D24_2)
-#> <mkinmod> model generated with
-#> Use of formation fractions $use_of_ff: max 
-#> Specification $spec:
-#> $D24
-#> $type: DFOP; $to: DCP; $sink: TRUE
-#> $DCP
-#> $type: SFO; $to: DCA; $sink: TRUE
-#> $DCA
-#> $type: SFO; $sink: TRUE
-#> Compiled model $cf available
-#> Differential equations:
-#> d_D24/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
-#>            time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
-#>            * D24
-#> d_DCP/dt = + f_D24_to_DCP * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) *
-#>            exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2
-#>            * time))) * D24 - k_DCP * DCP
-#> d_DCA/dt = + f_DCP_to_DCA * k_DCP * DCP - k_DCA * DCA
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/DFOP.solution-1.png b/docs/dev/reference/DFOP.solution-1.png deleted file mode 100644 index 6b78836f..00000000 Binary files a/docs/dev/reference/DFOP.solution-1.png and /dev/null differ diff --git a/docs/dev/reference/DFOP.solution.html b/docs/dev/reference/DFOP.solution.html deleted file mode 100644 index d462133c..00000000 --- a/docs/dev/reference/DFOP.solution.html +++ /dev/null @@ -1,202 +0,0 @@ - -Double First-Order in Parallel kinetics — DFOP.solution • mkin - - -
-
- - - -
-
-
-

Double First-Order in Parallel kinetics

- Source: R/parent_solutions.R - -
- -
-

Function describing decline from a defined starting value using the sum of -two exponential decline functions.

-
- -
- 
DFOP.solution(t, parent_0, k1, k2, g)
-
- -
-

Arguments

-
t
-

Time.

- - -
parent_0
-

Starting value for the response variable at time zero.

- - -
k1
-

First kinetic constant.

- - -
k2
-

Second kinetic constant.

- - -
g
-

Fraction of the starting value declining according to the first -kinetic constant.

- -
-
-

Value

- - -

The value of the response variable at time t.

-
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
-
-

See also

-

Other parent solutions: -FOMC.solution(), -HS.solution(), -IORE.solution(), -SFO.solution(), -SFORB.solution(), -logistic.solution()

-
- -
-

Examples

- 

-  plot(function(x) DFOP.solution(x, 100, 5, 0.5, 0.3), 0, 4, ylim = c(0,100))
-
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/Extract.mmkin.html b/docs/dev/reference/Extract.mmkin.html deleted file mode 100644 index 3a22d14b..00000000 --- a/docs/dev/reference/Extract.mmkin.html +++ /dev/null @@ -1,235 +0,0 @@ - -Subsetting method for mmkin objects — [.mmkin • mkin - - -
-
- - - -
-
-
-

Subsetting method for mmkin objects

- Source: R/mmkin.R - -
- -
-

Subsetting method for mmkin objects

-
- -
- 
# S3 method for mmkin
-[(x, i, j, ..., drop = FALSE)
-
- -
-

Arguments

-
x
-

An mmkin object

- - -
i
-

Row index selecting the fits for specific models

- - -
j
-

Column index selecting the fits to specific datasets

- - -
...
-

Not used, only there to satisfy the generic method definition

- - -
drop
-

If FALSE, the method always returns an mmkin object, otherwise -either a list of mkinfit objects or a single mkinfit object.

- -
-
-

Value

- - -

An object of class mmkin.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-  # Only use one core, to pass R CMD check --as-cran
-  fits <- mmkin(c("SFO", "FOMC"), list(B = FOCUS_2006_B, C = FOCUS_2006_C),
-                cores = 1, quiet = TRUE)
-  fits["FOMC", ]
-#> <mmkin> object
-#> Status of individual fits:
-#> 
-#>       dataset
-#> model  B  C 
-#>   FOMC OK OK
-#> 
-#> OK: No warnings
-  fits[, "B"]
-#> <mmkin> object
-#> Status of individual fits:
-#> 
-#>       dataset
-#> model  B 
-#>   SFO  OK
-#>   FOMC OK
-#> 
-#> OK: No warnings
-  fits["SFO", "B"]
-#> <mmkin> object
-#> Status of individual fits:
-#> 
-#>      dataset
-#> model B 
-#>   SFO OK
-#> 
-#> OK: No warnings
-
-  head(
-    # This extracts an mkinfit object with lots of components
-    fits[["FOMC", "B"]]
-  )
-#> $par
-#>  parent_0 log_alpha  log_beta     sigma 
-#> 99.666192  2.549850  5.050586  1.890202 
-#> 
-#> $objective
-#> [1] 28.58291
-#> 
-#> $convergence
-#> [1] 0
-#> 
-#> $iterations
-#> [1] 21
-#> 
-#> $evaluations
-#> function gradient 
-#>       25       78 
-#> 
-#> $message
-#> [1] "both X-convergence and relative convergence (5)"
-#> 
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/FOCUS_2006_DFOP_ref_A_to_B.html b/docs/dev/reference/FOCUS_2006_DFOP_ref_A_to_B.html deleted file mode 100644 index a8eb25cf..00000000 --- a/docs/dev/reference/FOCUS_2006_DFOP_ref_A_to_B.html +++ /dev/null @@ -1,189 +0,0 @@ - -Results of fitting the DFOP model to Datasets A to B of FOCUS (2006) — FOCUS_2006_DFOP_ref_A_to_B • mkin - - -
-
- - - -
-
-
-

Results of fitting the DFOP model to Datasets A to B of FOCUS (2006)

- - -
- -
-

A table with the fitted parameters and the resulting DT50 and DT90 values -generated with different software packages. Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit.

-
- -
- 
FOCUS_2006_DFOP_ref_A_to_B
-
- -
-

Format

-

A data frame containing the following variables.

package
-

a factor giving the name of the software package

- -
M0
-

The fitted initial concentration of the parent compound

- -
f
-

The fitted f parameter

- -
k1
-

The fitted k1 parameter

- -
k2
-

The fitted k2 parameter

- -
DT50
-

The resulting half-life of the parent compound

- -
DT90
-

The resulting DT90 of the parent compound

- -
dataset
-

The FOCUS dataset that was used

- - -
-
-

Source

-

FOCUS (2006) “Guidance Document on Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
- -
-

Examples

- 
data(FOCUS_2006_DFOP_ref_A_to_B)
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/FOCUS_2006_FOMC_ref_A_to_F.html b/docs/dev/reference/FOCUS_2006_FOMC_ref_A_to_F.html deleted file mode 100644 index 24297c78..00000000 --- a/docs/dev/reference/FOCUS_2006_FOMC_ref_A_to_F.html +++ /dev/null @@ -1,186 +0,0 @@ - -Results of fitting the FOMC model to Datasets A to F of FOCUS (2006) — FOCUS_2006_FOMC_ref_A_to_F • mkin - - -
-
- - - -
-
-
-

Results of fitting the FOMC model to Datasets A to F of FOCUS (2006)

- - -
- -
-

A table with the fitted parameters and the resulting DT50 and DT90 values -generated with different software packages. Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit.

-
- -
- 
FOCUS_2006_FOMC_ref_A_to_F
-
- -
-

Format

-

A data frame containing the following variables.

package
-

a factor giving the name of the software package

- -
M0
-

The fitted initial concentration of the parent compound

- -
alpha
-

The fitted alpha parameter

- -
beta
-

The fitted beta parameter

- -
DT50
-

The resulting half-life of the parent compound

- -
DT90
-

The resulting DT90 of the parent compound

- -
dataset
-

The FOCUS dataset that was used

- - -
-
-

Source

-

FOCUS (2006) “Guidance Document on Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
- -
-

Examples

- 
data(FOCUS_2006_FOMC_ref_A_to_F)
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/FOCUS_2006_HS_ref_A_to_F.html b/docs/dev/reference/FOCUS_2006_HS_ref_A_to_F.html deleted file mode 100644 index caf258ba..00000000 --- a/docs/dev/reference/FOCUS_2006_HS_ref_A_to_F.html +++ /dev/null @@ -1,189 +0,0 @@ - -Results of fitting the HS model to Datasets A to F of FOCUS (2006) — FOCUS_2006_HS_ref_A_to_F • mkin - - -
-
- - - -
-
-
-

Results of fitting the HS model to Datasets A to F of FOCUS (2006)

- - -
- -
-

A table with the fitted parameters and the resulting DT50 and DT90 values -generated with different software packages. Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit.

-
- -
- 
FOCUS_2006_HS_ref_A_to_F
-
- -
-

Format

-

A data frame containing the following variables.

package
-

a factor giving the name of the software package

- -
M0
-

The fitted initial concentration of the parent compound

- -
tb
-

The fitted tb parameter

- -
k1
-

The fitted k1 parameter

- -
k2
-

The fitted k2 parameter

- -
DT50
-

The resulting half-life of the parent compound

- -
DT90
-

The resulting DT90 of the parent compound

- -
dataset
-

The FOCUS dataset that was used

- - -
-
-

Source

-

FOCUS (2006) “Guidance Document on Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
- -
-

Examples

- 
data(FOCUS_2006_HS_ref_A_to_F)
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/FOCUS_2006_SFO_ref_A_to_F.html b/docs/dev/reference/FOCUS_2006_SFO_ref_A_to_F.html deleted file mode 100644 index bc3d1c08..00000000 --- a/docs/dev/reference/FOCUS_2006_SFO_ref_A_to_F.html +++ /dev/null @@ -1,183 +0,0 @@ - -Results of fitting the SFO model to Datasets A to F of FOCUS (2006) — FOCUS_2006_SFO_ref_A_to_F • mkin - - -
-
- - - -
-
-
-

Results of fitting the SFO model to Datasets A to F of FOCUS (2006)

- - -
- -
-

A table with the fitted parameters and the resulting DT50 and DT90 values -generated with different software packages. Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit.

-
- -
- 
FOCUS_2006_SFO_ref_A_to_F
-
- -
-

Format

-

A data frame containing the following variables.

package
-

a factor giving the name of the software package

- -
M0
-

The fitted initial concentration of the parent compound

- -
k
-

The fitted first-order degradation rate constant

- -
DT50
-

The resulting half-life of the parent compound

- -
DT90
-

The resulting DT90 of the parent compound

- -
dataset
-

The FOCUS dataset that was used

- - -
-
-

Source

-

FOCUS (2006) “Guidance Document on Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
- -
-

Examples

- 
data(FOCUS_2006_SFO_ref_A_to_F)
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/FOCUS_2006_datasets.html b/docs/dev/reference/FOCUS_2006_datasets.html deleted file mode 100644 index 78f8e81b..00000000 --- a/docs/dev/reference/FOCUS_2006_datasets.html +++ /dev/null @@ -1,181 +0,0 @@ - -Datasets A to F from the FOCUS Kinetics report from 2006 — FOCUS_2006_datasets • mkin - - -
-
- - - -
-
-
-

Datasets A to F from the FOCUS Kinetics report from 2006

- - -
- -
-

Data taken from FOCUS (2006), p. 258.

-
- -
- 
FOCUS_2006_A
-  FOCUS_2006_B
-  FOCUS_2006_C
-  FOCUS_2006_D
-  FOCUS_2006_E
-  FOCUS_2006_F
-
- -
-

Format

-

6 datasets with observations on the following variables.

name
-

a factor containing the name of the observed variable

- -
time
-

a numeric vector containing time points

- -
value
-

a numeric vector containing concentrations in percent of applied radioactivity

- - -
-
-

Source

-

FOCUS (2006) “Guidance Document on Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
- -
-

Examples

- 
FOCUS_2006_C
-#>     name time value
-#> 1 parent    0  85.1
-#> 2 parent    1  57.9
-#> 3 parent    3  29.9
-#> 4 parent    7  14.6
-#> 5 parent   14   9.7
-#> 6 parent   28   6.6
-#> 7 parent   63   4.0
-#> 8 parent   91   3.9
-#> 9 parent  119   0.6
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/FOMC.solution-1.png b/docs/dev/reference/FOMC.solution-1.png deleted file mode 100644 index 18a4b586..00000000 Binary files a/docs/dev/reference/FOMC.solution-1.png and /dev/null differ diff --git a/docs/dev/reference/FOMC.solution.html b/docs/dev/reference/FOMC.solution.html deleted file mode 100644 index e1813261..00000000 --- a/docs/dev/reference/FOMC.solution.html +++ /dev/null @@ -1,213 +0,0 @@ - -First-Order Multi-Compartment kinetics — FOMC.solution • mkin - - -
-
- - - -
-
-
-

First-Order Multi-Compartment kinetics

- Source: R/parent_solutions.R - -
- -
-

Function describing exponential decline from a defined starting value, with -a decreasing rate constant.

-
- -
- 
FOMC.solution(t, parent_0, alpha, beta)
-
- -
-

Arguments

-
t
-

Time.

- - -
parent_0
-

Starting value for the response variable at time zero.

- - -
alpha
-

Shape parameter determined by coefficient of variation of rate -constant values.

- - -
beta
-

Location parameter.

- -
-
-

Value

- - -

The value of the response variable at time t.

-
-
-

Details

-

The form given here differs slightly from the original reference by -Gustafson and Holden (1990). The parameter beta corresponds to 1/beta -in the original equation.

-
-
-

Note

-

The solution of the FOMC kinetic model reduces to the -SFO.solution for large values of alpha and beta -with \(k = \frac{\beta}{\alpha}\).

-
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-

FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-

Gustafson DI and Holden LR (1990) Nonlinear pesticide dissipation in soil: -A new model based on spatial variability. Environmental Science and -Technology 24, 1032-1038

-
-
-

See also

-

Other parent solutions: -DFOP.solution(), -HS.solution(), -IORE.solution(), -SFO.solution(), -SFORB.solution(), -logistic.solution()

-
- -
-

Examples

- 

-  plot(function(x) FOMC.solution(x, 100, 10, 2), 0, 2, ylim = c(0, 100))
-
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/HS.solution-1.png b/docs/dev/reference/HS.solution-1.png deleted file mode 100644 index 61d89dbc..00000000 Binary files a/docs/dev/reference/HS.solution-1.png and /dev/null differ diff --git a/docs/dev/reference/HS.solution.html b/docs/dev/reference/HS.solution.html deleted file mode 100644 index d42eaef6..00000000 --- a/docs/dev/reference/HS.solution.html +++ /dev/null @@ -1,203 +0,0 @@ - -Hockey-Stick kinetics — HS.solution • mkin - - -
-
- - - -
-
-
-

Hockey-Stick kinetics

- Source: R/parent_solutions.R - -
- -
-

Function describing two exponential decline functions with a break point -between them.

-
- -
- 
HS.solution(t, parent_0, k1, k2, tb)
-
- -
-

Arguments

-
t
-

Time.

- - -
parent_0
-

Starting value for the response variable at time zero.

- - -
k1
-

First kinetic constant.

- - -
k2
-

Second kinetic constant.

- - -
tb
-

Break point. Before this time, exponential decline according to -k1 is calculated, after this time, exponential decline proceeds -according to k2.

- -
-
-

Value

- - -

The value of the response variable at time t.

-
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
-
-

See also

-

Other parent solutions: -DFOP.solution(), -FOMC.solution(), -IORE.solution(), -SFO.solution(), -SFORB.solution(), -logistic.solution()

-
- -
-

Examples

- 

-  plot(function(x) HS.solution(x, 100, 2, 0.3, 0.5), 0, 2, ylim=c(0,100))
-
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/IORE.solution-1.png b/docs/dev/reference/IORE.solution-1.png deleted file mode 100644 index 54c9dcae..00000000 Binary files a/docs/dev/reference/IORE.solution-1.png and /dev/null differ diff --git a/docs/dev/reference/IORE.solution.html b/docs/dev/reference/IORE.solution.html deleted file mode 100644 index b9d4734f..00000000 --- a/docs/dev/reference/IORE.solution.html +++ /dev/null @@ -1,218 +0,0 @@ - -Indeterminate order rate equation kinetics — IORE.solution • mkin - - -
-
- - - -
-
-
-

Indeterminate order rate equation kinetics

- Source: R/parent_solutions.R - -
- -
-

Function describing exponential decline from a defined starting value, with -a concentration dependent rate constant.

-
- -
- 
IORE.solution(t, parent_0, k__iore, N)
-
- -
-

Arguments

-
t
-

Time.

- - -
parent_0
-

Starting value for the response variable at time zero.

- - -
k__iore
-

Rate constant. Note that this depends on the concentration -units used.

- - -
N
-

Exponent describing the nonlinearity of the rate equation

- -
-
-

Value

- - -

The value of the response variable at time t.

-
-
-

Note

-

The solution of the IORE kinetic model reduces to the -SFO.solution if N = 1. The parameters of the IORE model can -be transformed to equivalent parameters of the FOMC mode - see the NAFTA -guidance for details.

-
-
-

References

-

NAFTA Technical Working Group on Pesticides (not dated) Guidance -for Evaluating and Calculating Degradation Kinetics in Environmental Media

-
-
-

See also

-

Other parent solutions: -DFOP.solution(), -FOMC.solution(), -HS.solution(), -SFO.solution(), -SFORB.solution(), -logistic.solution()

-
- -
-

Examples

- 

-  plot(function(x) IORE.solution(x, 100, 0.2, 1.3), 0, 2, ylim = c(0, 100))
-
-  # \dontrun{
-    fit.fomc <- mkinfit("FOMC", FOCUS_2006_C, quiet = TRUE)
-    fit.iore <- mkinfit("IORE", FOCUS_2006_C, quiet = TRUE)
-    fit.iore.deS <- mkinfit("IORE", FOCUS_2006_C, solution_type = "deSolve", quiet = TRUE)
-#> Error in is.loaded(initfunc, PACKAGE = dllname, type = "") : 
-#>   invalid 'PACKAGE' argument
-
-    print(data.frame(fit.fomc$par, fit.iore$par, fit.iore.deS$par,
-                     row.names = paste("model par", 1:4)))
-#>             fit.fomc.par fit.iore.par fit.iore.deS.par
-#> model par 1  85.87489063    85.874890        85.874890
-#> model par 2   0.05192238    -4.826631        -4.826631
-#> model par 3   0.65096665     1.949403         1.949403
-#> model par 4   1.85744396     1.857444         1.857444
-    print(rbind(fomc = endpoints(fit.fomc)$distimes, iore = endpoints(fit.iore)$distimes,
-                iore.deS = endpoints(fit.iore)$distimes))
-#>              DT50    DT90 DT50back
-#> fomc     1.785233 15.1479 4.559973
-#> iore     1.785233 15.1479 4.559973
-#> iore.deS 1.785233 15.1479 4.559973
-  # }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/NAFTA_SOP_2015-1.png b/docs/dev/reference/NAFTA_SOP_2015-1.png deleted file mode 100644 index 98d4246c..00000000 Binary files a/docs/dev/reference/NAFTA_SOP_2015-1.png and /dev/null differ diff --git a/docs/dev/reference/NAFTA_SOP_2015.html b/docs/dev/reference/NAFTA_SOP_2015.html deleted file mode 100644 index 299863d7..00000000 --- a/docs/dev/reference/NAFTA_SOP_2015.html +++ /dev/null @@ -1,215 +0,0 @@ - -Example datasets from the NAFTA SOP published 2015 — NAFTA_SOP_2015 • mkin - - -
-
- - - -
-
-
-

Example datasets from the NAFTA SOP published 2015

- - -
- -
-

Data taken from US EPA (2015), p. 19 and 23.

-
- -
- 
NAFTA_SOP_Appendix_B
-  NAFTA_SOP_Appendix_D
-
- -
-

Format

-

2 datasets with observations on the following variables.

name
-

a factor containing the name of the observed variable

- -
time
-

a numeric vector containing time points

- -
value
-

a numeric vector containing concentrations

- - -
-
-

Source

-

NAFTA (2011) Guidance for evaluating and calculating degradation kinetics - in environmental media. NAFTA Technical Working Group on Pesticides - https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation - accessed 2019-02-22

-

US EPA (2015) Standard Operating Procedure for Using the NAFTA Guidance to - Calculate Representative Half-life Values and Characterizing Pesticide - Degradation - https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance

-
- -
-

Examples

- 
  nafta_evaluation <- nafta(NAFTA_SOP_Appendix_D, cores = 1)
-#> The SFO model is rejected as S_SFO is equal or higher than the critical value S_c
-#> The representative half-life of the IORE model is longer than the one corresponding
-#> to the terminal degradation rate found with the DFOP model.
-#> The representative half-life obtained from the DFOP model may be used
-  print(nafta_evaluation)
-#> Sums of squares:
-#>       SFO      IORE      DFOP 
-#> 1378.6832  615.7730  517.8836 
-#> 
-#> Critical sum of squares for checking the SFO model:
-#> [1] 717.4598
-#> 
-#> Parameters:
-#> $SFO
-#>          Estimate   Pr(>t)    Lower   Upper
-#> parent_0  83.7558 1.80e-14 77.18268 90.3288
-#> k_parent   0.0017 7.43e-05  0.00112  0.0026
-#> sigma      8.7518 1.22e-05  5.64278 11.8608
-#> 
-#> $IORE
-#>                Estimate Pr(>t)    Lower    Upper
-#> parent_0       9.69e+01     NA 8.88e+01 1.05e+02
-#> k__iore_parent 8.40e-14     NA 1.79e-18 3.94e-09
-#> N_parent       6.68e+00     NA 4.19e+00 9.17e+00
-#> sigma          5.85e+00     NA 3.76e+00 7.94e+00
-#> 
-#> $DFOP
-#>          Estimate   Pr(>t)    Lower    Upper
-#> parent_0 9.76e+01 1.94e-13 9.02e+01 1.05e+02
-#> k1       4.24e-02 5.92e-03 2.03e-02 8.88e-02
-#> k2       8.24e-04 6.48e-03 3.89e-04 1.75e-03
-#> g        2.88e-01 2.47e-05 1.95e-01 4.03e-01
-#> sigma    5.36e+00 2.22e-05 3.43e+00 7.30e+00
-#> 
-#> 
-#> DTx values:
-#>      DT50    DT90 DT50_rep
-#> SFO   407    1350      407
-#> IORE  541 5190000  1560000
-#> DFOP  429    2380      841
-#> 
-#> Representative half-life:
-#> [1] 841.41
-  plot(nafta_evaluation)
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/NAFTA_SOP_Attachment-1.png b/docs/dev/reference/NAFTA_SOP_Attachment-1.png deleted file mode 100644 index a6066441..00000000 Binary files a/docs/dev/reference/NAFTA_SOP_Attachment-1.png and /dev/null differ diff --git a/docs/dev/reference/NAFTA_SOP_Attachment.html b/docs/dev/reference/NAFTA_SOP_Attachment.html deleted file mode 100644 index 6bc86b46..00000000 --- a/docs/dev/reference/NAFTA_SOP_Attachment.html +++ /dev/null @@ -1,204 +0,0 @@ - -Example datasets from Attachment 1 to the NAFTA SOP published 2015 — NAFTA_SOP_Attachment • mkin - - -
-
- - - -
-
-
-

Example datasets from Attachment 1 to the NAFTA SOP published 2015

- - -
- -
-

Data taken from from Attachment 1 of the SOP.

-
- -
- 
NAFTA_SOP_Attachment
-
- -
-

Format

-

A list (NAFTA_SOP_Attachment) containing 16 datasets suitable - for the evaluation with nafta

-
-
-

Source

-

NAFTA (2011) Guidance for evaluating and calculating degradation kinetics - in environmental media. NAFTA Technical Working Group on Pesticides - https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation - accessed 2019-02-22

-

US EPA (2015) Standard Operating Procedure for Using the NAFTA Guidance to - Calculate Representative Half-life Values and Characterizing Pesticide - Degradation - https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance

-
- -
-

Examples

- 
  nafta_att_p5a <- nafta(NAFTA_SOP_Attachment[["p5a"]], cores = 1)
-#> The SFO model is rejected as S_SFO is equal or higher than the critical value S_c
-#> The half-life obtained from the IORE model may be used
-  print(nafta_att_p5a)
-#> Sums of squares:
-#>       SFO      IORE      DFOP 
-#> 465.21753  56.27506  32.06401 
-#> 
-#> Critical sum of squares for checking the SFO model:
-#> [1] 64.4304
-#> 
-#> Parameters:
-#> $SFO
-#>          Estimate   Pr(>t)  Lower   Upper
-#> parent_0  95.8401 4.67e-21 92.245 99.4357
-#> k_parent   0.0102 3.92e-12  0.009  0.0117
-#> sigma      4.8230 3.81e-06  3.214  6.4318
-#> 
-#> $IORE
-#>                Estimate Pr(>t)    Lower    Upper
-#> parent_0       1.01e+02     NA 9.91e+01 1.02e+02
-#> k__iore_parent 1.54e-05     NA 4.08e-06 5.84e-05
-#> N_parent       2.57e+00     NA 2.25e+00 2.89e+00
-#> sigma          1.68e+00     NA 1.12e+00 2.24e+00
-#> 
-#> $DFOP
-#>          Estimate   Pr(>t)   Lower    Upper
-#> parent_0 9.99e+01 1.41e-26 98.8116 101.0810
-#> k1       2.67e-02 5.05e-06  0.0243   0.0295
-#> k2       2.26e-12 5.00e-01  0.0000      Inf
-#> g        6.47e-01 3.67e-06  0.6248   0.6677
-#> sigma    1.27e+00 8.91e-06  0.8395   1.6929
-#> 
-#> 
-#> DTx values:
-#>      DT50     DT90 DT50_rep
-#> SFO  67.7 2.25e+02 6.77e+01
-#> IORE 58.2 1.07e+03 3.22e+02
-#> DFOP 55.5 5.59e+11 3.07e+11
-#> 
-#> Representative half-life:
-#> [1] 321.51
-  plot(nafta_att_p5a)
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/Rplot001.png b/docs/dev/reference/Rplot001.png deleted file mode 100644 index 70d084a3..00000000 Binary files a/docs/dev/reference/Rplot001.png and /dev/null differ diff --git a/docs/dev/reference/Rplot002.png b/docs/dev/reference/Rplot002.png deleted file mode 100644 index 0f7d4405..00000000 Binary files a/docs/dev/reference/Rplot002.png and /dev/null differ diff --git a/docs/dev/reference/Rplot003.png b/docs/dev/reference/Rplot003.png deleted file mode 100644 index 30cf38f3..00000000 Binary files a/docs/dev/reference/Rplot003.png and /dev/null differ diff --git a/docs/dev/reference/Rplot004.png b/docs/dev/reference/Rplot004.png deleted file mode 100644 index 377229db..00000000 Binary files a/docs/dev/reference/Rplot004.png and /dev/null differ diff --git a/docs/dev/reference/Rplot005.png b/docs/dev/reference/Rplot005.png deleted file mode 100644 index c1324477..00000000 Binary files a/docs/dev/reference/Rplot005.png and /dev/null differ diff --git a/docs/dev/reference/Rplot006.png b/docs/dev/reference/Rplot006.png deleted file mode 100644 index f646fa66..00000000 Binary files a/docs/dev/reference/Rplot006.png and /dev/null differ diff --git a/docs/dev/reference/Rplot007.png b/docs/dev/reference/Rplot007.png deleted file mode 100644 index d3b6ddd4..00000000 Binary files a/docs/dev/reference/Rplot007.png and /dev/null differ diff --git a/docs/dev/reference/SFO.solution-1.png b/docs/dev/reference/SFO.solution-1.png deleted file mode 100644 index 34fdd460..00000000 Binary files a/docs/dev/reference/SFO.solution-1.png and /dev/null differ diff --git a/docs/dev/reference/SFO.solution.html b/docs/dev/reference/SFO.solution.html deleted file mode 100644 index 08e031e7..00000000 --- a/docs/dev/reference/SFO.solution.html +++ /dev/null @@ -1,191 +0,0 @@ - -Single First-Order kinetics — SFO.solution • mkin - - -
-
- - - -
-
-
-

Single First-Order kinetics

- Source: R/parent_solutions.R - -
- -
-

Function describing exponential decline from a defined starting value.

-
- -
- 
SFO.solution(t, parent_0, k)
-
- -
-

Arguments

-
t
-

Time.

- - -
parent_0
-

Starting value for the response variable at time zero.

- - -
k
-

Kinetic rate constant.

- -
-
-

Value

- - -

The value of the response variable at time t.

-
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
-
-

See also

-

Other parent solutions: -DFOP.solution(), -FOMC.solution(), -HS.solution(), -IORE.solution(), -SFORB.solution(), -logistic.solution()

-
- -
-

Examples

- 

-  plot(function(x) SFO.solution(x, 100, 3), 0, 2)
-
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/SFORB.solution-1.png b/docs/dev/reference/SFORB.solution-1.png deleted file mode 100644 index 08d25616..00000000 Binary files a/docs/dev/reference/SFORB.solution-1.png and /dev/null differ diff --git a/docs/dev/reference/SFORB.solution.html b/docs/dev/reference/SFORB.solution.html deleted file mode 100644 index 7e584ace..00000000 --- a/docs/dev/reference/SFORB.solution.html +++ /dev/null @@ -1,209 +0,0 @@ - -Single First-Order Reversible Binding kinetics — SFORB.solution • mkin - - -
-
- - - -
-
-
-

Single First-Order Reversible Binding kinetics

- Source: R/parent_solutions.R - -
- -
-

Function describing the solution of the differential equations describing -the kinetic model with first-order terms for a two-way transfer from a free -to a bound fraction, and a first-order degradation term for the free -fraction. The initial condition is a defined amount in the free fraction -and no substance in the bound fraction.

-
- -
- 
SFORB.solution(t, parent_0, k_12, k_21, k_1output)
-
- -
-

Arguments

-
t
-

Time.

- - -
parent_0
-

Starting value for the response variable at time zero.

- - -
k_12
-

Kinetic constant describing transfer from free to bound.

- - -
k_21
-

Kinetic constant describing transfer from bound to free.

- - -
k_1output
-

Kinetic constant describing degradation of the free -fraction.

- -
-
-

Value

- - -

The value of the response variable, which is the sum of free and -bound fractions at time t.

-
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
-
-

See also

-

Other parent solutions: -DFOP.solution(), -FOMC.solution(), -HS.solution(), -IORE.solution(), -SFO.solution(), -logistic.solution()

-
- -
-

Examples

- 

-  plot(function(x) SFORB.solution(x, 100, 0.5, 2, 3), 0, 2)
-
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/add_err-1.png b/docs/dev/reference/add_err-1.png deleted file mode 100644 index 68cfb344..00000000 Binary files a/docs/dev/reference/add_err-1.png and /dev/null differ diff --git a/docs/dev/reference/add_err-2.png b/docs/dev/reference/add_err-2.png deleted file mode 100644 index d2f0cf08..00000000 Binary files a/docs/dev/reference/add_err-2.png and /dev/null differ diff --git a/docs/dev/reference/add_err-3.png b/docs/dev/reference/add_err-3.png deleted file mode 100644 index 17b5416a..00000000 Binary files a/docs/dev/reference/add_err-3.png and /dev/null differ diff --git a/docs/dev/reference/add_err.html b/docs/dev/reference/add_err.html deleted file mode 100644 index 57db40d1..00000000 --- a/docs/dev/reference/add_err.html +++ /dev/null @@ -1,262 +0,0 @@ - -Add normally distributed errors to simulated kinetic degradation data — add_err • mkin - - -
-
- - - -
-
-
-

Add normally distributed errors to simulated kinetic degradation data

- Source: R/add_err.R - -
- -
-

Normally distributed errors are added to data predicted for a specific -degradation model using mkinpredict. The variance of the error -may depend on the predicted value and is specified as a standard deviation.

-
- -
- 
add_err(
-  prediction,
-  sdfunc,
-  secondary = c("M1", "M2"),
-  n = 10,
-  LOD = 0.1,
-  reps = 2,
-  digits = 1,
-  seed = NA
-)
-
- -
-

Arguments

-
prediction
-

A prediction from a kinetic model as produced by -mkinpredict.

- - -
sdfunc
-

A function taking the predicted value as its only argument and -returning a standard deviation that should be used for generating the -random error terms for this value.

- - -
secondary
-

The names of state variables that should have an initial -value of zero

- - -
n
-

The number of datasets to be generated.

- - -
LOD
-

The limit of detection (LOD). Values that are below the LOD after -adding the random error will be set to NA.

- - -
reps
-

The number of replicates to be generated within the datasets.

- - -
digits
-

The number of digits to which the values will be rounded.

- - -
seed
-

The seed used for the generation of random numbers. If NA, the -seed is not set.

- -
-
-

Value

- - -

A list of datasets compatible with mmkin, i.e. the -components of the list are datasets compatible with mkinfit.

-
-
-

References

-

Ranke J and Lehmann R (2015) To t-test or not to t-test, that is -the question. XV Symposium on Pesticide Chemistry 2-4 September 2015, -Piacenza, Italy -https://jrwb.de/posters/piacenza_2015.pdf

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-# The kinetic model
-m_SFO_SFO <- mkinmod(parent = mkinsub("SFO", "M1"),
-                     M1 = mkinsub("SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-# Generate a prediction for a specific set of parameters
-sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-
-# This is the prediction used for the "Type 2 datasets" on the Piacenza poster
-# from 2015
-d_SFO_SFO <- mkinpredict(m_SFO_SFO,
-                         c(k_parent = 0.1, f_parent_to_M1 = 0.5,
-                           k_M1 = log(2)/1000),
-                         c(parent = 100, M1 = 0),
-                         sampling_times)
-
-# Add an error term with a constant (independent of the value) standard deviation
-# of 10, and generate three datasets
-d_SFO_SFO_err <- add_err(d_SFO_SFO, function(x) 10, n = 3, seed = 123456789 )
-
-# Name the datasets for nicer plotting
-names(d_SFO_SFO_err) <- paste("Dataset", 1:3)
-
-# Name the model in the list of models (with only one member in this case) for
-# nicer plotting later on.  Be quiet and use only one core not to offend CRAN
-# checks
-# \dontrun{
-f_SFO_SFO <- mmkin(list("SFO-SFO" = m_SFO_SFO),
-                   d_SFO_SFO_err, cores = 1,
-                   quiet = TRUE)
-
-plot(f_SFO_SFO)
-
-
-# We would like to inspect the fit for dataset 3 more closely
-# Using double brackets makes the returned object an mkinfit object
-# instead of a list of mkinfit objects, so plot.mkinfit is used
-plot(f_SFO_SFO[[3]], show_residuals = TRUE)
-
-
-# If we use single brackets, we should give two indices (model and dataset),
-# and plot.mmkin is used
-plot(f_SFO_SFO[1, 3])
-
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/anova.saem.mmkin.html b/docs/dev/reference/anova.saem.mmkin.html deleted file mode 100644 index 39a30dff..00000000 --- a/docs/dev/reference/anova.saem.mmkin.html +++ /dev/null @@ -1,185 +0,0 @@ - -Anova method for saem.mmkin objects — anova.saem.mmkin • mkin - - -
-
- - - -
-
-
-

Anova method for saem.mmkin objects

- Source: R/anova.saem.mmkin.R - -
- -
-

Generate an anova object. The method to calculate the BIC is that from the -saemix package. As in other prominent anova methods, models are sorted by -number of parameters, and the tests (if requested) are always relative to -the model on the previous line.

-
- -
- 
# S3 method for saem.mmkin
-anova(
-  object,
-  ...,
-  method = c("is", "lin", "gq"),
-  test = FALSE,
-  model.names = NULL
-)
-
- -
-

Arguments

-
object
-

An saem.mmkin object

- - -
...
-

further such objects

- - -
method
-

Method for likelihood calculation: "is" (importance sampling), -"lin" (linear approximation), or "gq" (Gaussian quadrature). Passed -to saemix::logLik.SaemixObject

- - -
test
-

Should a likelihood ratio test be performed? If TRUE, -the alternative models are tested against the first model. Should -only be done for nested models.

- - -
model.names
-

Optional character vector of model names

- -
-
-

Value

- - -

an "anova" data frame; the traditional (S3) result of anova()

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/aw.html b/docs/dev/reference/aw.html deleted file mode 100644 index fc5ff777..00000000 --- a/docs/dev/reference/aw.html +++ /dev/null @@ -1,197 +0,0 @@ - -Calculate Akaike weights for model averaging — aw • mkin - - -
-
- - - -
-
-
-

Calculate Akaike weights for model averaging

- Source: R/aw.R - -
- -
-

Akaike weights are calculated based on the relative -expected Kullback-Leibler information as specified -by Burnham and Anderson (2004).

-
- -
- 
aw(object, ...)
-
-# S3 method for mkinfit
-aw(object, ...)
-
-# S3 method for mmkin
-aw(object, ...)
-
-# S3 method for mixed.mmkin
-aw(object, ...)
-
-# S3 method for multistart
-aw(object, ...)
-
- -
-

Arguments

-
object
-

An mmkin column object, containing two or more -mkinfit models that have been fitted to the same data, -or an mkinfit object. In the latter case, further mkinfit -objects fitted to the same data should be specified -as dots arguments.

- - -
...
-

Not used in the method for mmkin column objects, -further mkinfit objects in the method for mkinfit objects.

- -
-
-

References

-

Burnham KP and Anderson DR (2004) Multimodel -Inference: Understanding AIC and BIC in Model Selection. -Sociological Methods & Research 33(2) 261-304

-
- -
-

Examples

- 
# \dontrun{
-f_sfo <- mkinfit("SFO", FOCUS_2006_D, quiet = TRUE)
-f_dfop <- mkinfit("DFOP", FOCUS_2006_D, quiet = TRUE)
-aw_sfo_dfop <- aw(f_sfo, f_dfop)
-sum(aw_sfo_dfop)
-#> [1] 1
-aw_sfo_dfop # SFO gets more weight as it has less parameters and a similar fit
-#> [1] 0.5970258 0.4029742
-f <- mmkin(c("SFO", "FOMC", "DFOP"), list("FOCUS D" = FOCUS_2006_D), cores = 1, quiet = TRUE)
-aw(f)
-#> [1] 0.4808722 0.1945539 0.3245740
-sum(aw(f))
-#> [1] 1
-aw(f[c("SFO", "DFOP")])
-#> [1] 0.5970258 0.4029742
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/confint.mkinfit.html b/docs/dev/reference/confint.mkinfit.html deleted file mode 100644 index a3571fa5..00000000 --- a/docs/dev/reference/confint.mkinfit.html +++ /dev/null @@ -1,423 +0,0 @@ - -Confidence intervals for parameters of mkinfit objects — confint.mkinfit • mkin - - -
-
- - - -
-
-
-

Confidence intervals for parameters of mkinfit objects

- Source: R/confint.mkinfit.R - -
- -
-

The default method 'quadratic' is based on the quadratic approximation of -the curvature of the likelihood function at the maximum likelihood parameter -estimates. -The alternative method 'profile' is based on the profile likelihood for each -parameter. The 'profile' method uses two nested optimisations and can take a -very long time, even if parallelized by specifying 'cores' on unixoid -platforms. The speed of the method could likely be improved by using the -method of Venzon and Moolgavkar (1988).

-
- -
- 
# S3 method for mkinfit
-confint(
-  object,
-  parm,
-  level = 0.95,
-  alpha = 1 - level,
-  cutoff,
-  method = c("quadratic", "profile"),
-  transformed = TRUE,
-  backtransform = TRUE,
-  cores = parallel::detectCores(),
-  rel_tol = 0.01,
-  quiet = FALSE,
-  ...
-)
-
- -
-

Arguments

-
object
-

An mkinfit object

- - -
parm
-

A vector of names of the parameters which are to be given -confidence intervals. If missing, all parameters are considered.

- - -
level
-

The confidence level required

- - -
alpha
-

The allowed error probability, overrides 'level' if specified.

- - -
cutoff
-

Possibility to specify an alternative cutoff for the difference -in the log-likelihoods at the confidence boundary. Specifying an explicit -cutoff value overrides arguments 'level' and 'alpha'

- - -
method
-

The 'quadratic' method approximates the likelihood function at -the optimised parameters using the second term of the Taylor expansion, -using a second derivative (hessian) contained in the object. -The 'profile' method searches the parameter space for the -cutoff of the confidence intervals by means of a likelihood ratio test.

- - -
transformed
-

If the quadratic approximation is used, should it be -applied to the likelihood based on the transformed parameters?

- - -
backtransform
-

If we approximate the likelihood in terms of the -transformed parameters, should we backtransform the parameters with -their confidence intervals?

- - -
cores
-

The number of cores to be used for multicore processing. -On Windows machines, cores > 1 is currently not supported.

- - -
rel_tol
-

If the method is 'profile', what should be the accuracy -of the lower and upper bounds, relative to the estimate obtained from -the quadratic method?

- - -
quiet
-

Should we suppress the message "Profiling the likelihood"

- - -
...
-

Not used

- -
-
-

Value

- - -

A matrix with columns giving lower and upper confidence limits for -each parameter.

-
-
-

References

-

Bates DM and Watts GW (1988) Nonlinear regression analysis & its applications

-

Pawitan Y (2013) In all likelihood - Statistical modelling and -inference using likelihood. Clarendon Press, Oxford.

-

Venzon DJ and Moolgavkar SH (1988) A Method for Computing -Profile-Likelihood Based Confidence Intervals, Applied Statistics, 37, -87–94.

-
- -
-

Examples

- 
f <- mkinfit("SFO", FOCUS_2006_C, quiet = TRUE)
-confint(f, method = "quadratic")
-#>                2.5%      97.5%
-#> parent_0 71.8242430 93.1600766
-#> k_parent  0.2109541  0.4440528
-#> sigma     1.9778868  7.3681380
-
-# \dontrun{
-confint(f, method = "profile")
-#> Profiling the likelihood
-#>                2.5%      97.5%
-#> parent_0 73.0641834 92.1392181
-#> k_parent  0.2170293  0.4235348
-#> sigma     3.1307772  8.0628314
-
-# Set the number of cores for the profiling method for further examples
-if (identical(Sys.getenv("NOT_CRAN"), "true")) {
-  n_cores <- parallel::detectCores() - 1
-} else {
-  n_cores <- 1
-}
-if (Sys.getenv("TRAVIS") != "") n_cores = 1
-if (Sys.info()["sysname"] == "Windows") n_cores = 1
-
-SFO_SFO <- mkinmod(parent = mkinsub("SFO", "m1"), m1 = mkinsub("SFO"),
-  use_of_ff = "min", quiet = TRUE)
-SFO_SFO.ff <- mkinmod(parent = mkinsub("SFO", "m1"), m1 = mkinsub("SFO"),
-  use_of_ff = "max", quiet = TRUE)
-f_d_1 <- mkinfit(SFO_SFO, subset(FOCUS_2006_D, value != 0), quiet = TRUE)
-system.time(ci_profile <- confint(f_d_1, method = "profile", cores = 1, quiet = TRUE))
-#>    user  system elapsed 
-#>   1.183   0.000   1.182 
-# Using more cores does not save much time here, as parent_0 takes up most of the time
-# If we additionally exclude parent_0 (the confidence of which is often of
-# minor interest), we get a nice performance improvement if we use at least 4 cores
-system.time(ci_profile_no_parent_0 <- confint(f_d_1, method = "profile",
-  c("k_parent_sink", "k_parent_m1", "k_m1_sink", "sigma"), cores = n_cores))
-#> Profiling the likelihood
-#>    user  system elapsed 
-#>   0.418   0.116   0.294 
-ci_profile
-#>                       2.5%        97.5%
-#> parent_0      96.456003640 1.027703e+02
-#> k_parent_sink  0.040762501 5.549764e-02
-#> k_parent_m1    0.046786482 5.500879e-02
-#> k_m1_sink      0.003892605 6.702778e-03
-#> sigma          2.535612399 3.985263e+00
-ci_quadratic_transformed <- confint(f_d_1, method = "quadratic")
-ci_quadratic_transformed
-#>                       2.5%        97.5%
-#> parent_0      96.403841640 1.027931e+02
-#> k_parent_sink  0.041033378 5.596269e-02
-#> k_parent_m1    0.046777902 5.511931e-02
-#> k_m1_sink      0.004012217 6.897547e-03
-#> sigma          2.396089689 3.854918e+00
-ci_quadratic_untransformed <- confint(f_d_1, method = "quadratic", transformed = FALSE)
-ci_quadratic_untransformed
-#>                       2.5%        97.5%
-#> parent_0      96.403841645 102.79312449
-#> k_parent_sink  0.040485331   0.05535491
-#> k_parent_m1    0.046611582   0.05494364
-#> k_m1_sink      0.003835483   0.00668582
-#> sigma          2.396089689   3.85491806
-# Against the expectation based on Bates and Watts (1988), the confidence
-# intervals based on the internal parameter transformation are less
-# congruent with the likelihood based intervals. Note the superiority of the
-# interval based on the untransformed fit for k_m1_sink
-rel_diffs_transformed <- abs((ci_quadratic_transformed - ci_profile)/ci_profile)
-rel_diffs_untransformed <- abs((ci_quadratic_untransformed - ci_profile)/ci_profile)
-rel_diffs_transformed < rel_diffs_untransformed
-#>                2.5% 97.5%
-#> parent_0      FALSE FALSE
-#> k_parent_sink  TRUE FALSE
-#> k_parent_m1    TRUE FALSE
-#> k_m1_sink     FALSE FALSE
-#> sigma         FALSE FALSE
-signif(rel_diffs_transformed, 3)
-#>                   2.5%    97.5%
-#> parent_0      0.000541 0.000222
-#> k_parent_sink 0.006650 0.008380
-#> k_parent_m1   0.000183 0.002010
-#> k_m1_sink     0.030700 0.029100
-#> sigma         0.055000 0.032700
-signif(rel_diffs_untransformed, 3)
-#>                   2.5%    97.5%
-#> parent_0      0.000541 0.000222
-#> k_parent_sink 0.006800 0.002570
-#> k_parent_m1   0.003740 0.001180
-#> k_m1_sink     0.014700 0.002530
-#> sigma         0.055000 0.032700
-
-
-# Investigate a case with formation fractions
-f_d_2 <- mkinfit(SFO_SFO.ff, subset(FOCUS_2006_D, value != 0), quiet = TRUE)
-ci_profile_ff <- confint(f_d_2, method = "profile", cores = n_cores)
-#> Profiling the likelihood
-ci_profile_ff
-#>                        2.5%        97.5%
-#> parent_0       96.456003640 1.027703e+02
-#> k_parent        0.090911032 1.071578e-01
-#> k_m1            0.003892606 6.702775e-03
-#> f_parent_to_m1  0.471328495 5.611550e-01
-#> sigma           2.535612399 3.985263e+00
-ci_quadratic_transformed_ff <- confint(f_d_2, method = "quadratic")
-ci_quadratic_transformed_ff
-#>                        2.5%        97.5%
-#> parent_0       96.403833578 102.79311649
-#> k_parent        0.090823771   0.10725430
-#> k_m1            0.004012219   0.00689755
-#> f_parent_to_m1  0.469118824   0.55959615
-#> sigma           2.396089689   3.85491806
-ci_quadratic_untransformed_ff <- confint(f_d_2, method = "quadratic", transformed = FALSE)
-ci_quadratic_untransformed_ff
-#>                        2.5%        97.5%
-#> parent_0       96.403833583 1.027931e+02
-#> k_parent        0.090491913 1.069035e-01
-#> k_m1            0.003835485 6.685823e-03
-#> f_parent_to_m1  0.469113477 5.598387e-01
-#> sigma           2.396089689 3.854918e+00
-rel_diffs_transformed_ff <- abs((ci_quadratic_transformed_ff - ci_profile_ff)/ci_profile_ff)
-rel_diffs_untransformed_ff <- abs((ci_quadratic_untransformed_ff - ci_profile_ff)/ci_profile_ff)
-# While the confidence interval for the parent rate constant is closer to
-# the profile based interval when using the internal parameter
-# transformation, the interval for the metabolite rate constant is 'better
-# without internal parameter transformation.
-rel_diffs_transformed_ff < rel_diffs_untransformed_ff
-#>                 2.5% 97.5%
-#> parent_0       FALSE FALSE
-#> k_parent        TRUE  TRUE
-#> k_m1           FALSE FALSE
-#> f_parent_to_m1  TRUE FALSE
-#> sigma           TRUE FALSE
-rel_diffs_transformed_ff
-#>                        2.5%        97.5%
-#> parent_0       0.0005408690 0.0002217233
-#> k_parent       0.0009598532 0.0009001864
-#> k_m1           0.0307283041 0.0290588361
-#> f_parent_to_m1 0.0046881769 0.0027780063
-#> sigma          0.0550252516 0.0327066836
-rel_diffs_untransformed_ff
-#>                        2.5%        97.5%
-#> parent_0       0.0005408689 0.0002217232
-#> k_parent       0.0046102156 0.0023732281
-#> k_m1           0.0146740690 0.0025291820
-#> f_parent_to_m1 0.0046995211 0.0023457712
-#> sigma          0.0550252516 0.0327066836
-
-# The profiling for the following fit does not finish in a reasonable time,
-# therefore we use the quadratic approximation
-m_synth_DFOP_par <- mkinmod(parent = mkinsub("DFOP", c("M1", "M2")),
-  M1 = mkinsub("SFO"),
-  M2 = mkinsub("SFO"),
-  use_of_ff = "max", quiet = TRUE)
-DFOP_par_c <- synthetic_data_for_UBA_2014[[12]]$data
-f_tc_2 <- mkinfit(m_synth_DFOP_par, DFOP_par_c, error_model = "tc",
-  error_model_algorithm = "direct", quiet = TRUE)
-confint(f_tc_2, method = "quadratic")
-#>                        2.5%        97.5%
-#> parent_0       94.596039609 106.19954892
-#> k_M1            0.037605368   0.04490762
-#> k_M2            0.008568731   0.01087676
-#> f_parent_to_M1  0.021462489   0.62023882
-#> f_parent_to_M2  0.015165617   0.37975348
-#> k1              0.273897348   0.33388101
-#> k2              0.018614554   0.02250378
-#> g               0.671943411   0.73583305
-#> sigma_low       0.251283495   0.83992077
-#> rsd_high        0.040411024   0.07662008
-confint(f_tc_2, "parent_0", method = "quadratic")
-#>              2.5%    97.5%
-#> parent_0 94.59604 106.1995
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/convergence.html b/docs/dev/reference/convergence.html deleted file mode 100644 index e9fac3bb..00000000 --- a/docs/dev/reference/convergence.html +++ /dev/null @@ -1,163 +0,0 @@ - -Method to get convergence information — convergence • mkin - - -
-
- - - -
-
-
-

Method to get convergence information

- Source: R/convergence.R - -
- -
-

Method to get convergence information

-
- -
- 
convergence(object, ...)
-
-# S3 method for mmkin
-convergence(object, ...)
-
-# S3 method for convergence.mmkin
-print(x, ...)
-
- -
-

Arguments

-
object
-

The object to investigate

- - -
...
-

For potential future extensions

- - -
x
-

The object to be printed

- -
-
-

Value

- - -

For mkinfit objects, a character vector containing -For mmkin objects, an object of class 'convergence.mmkin' with a -suitable printing method.

-
- -
-

Examples

- 
# \dontrun{
-fits <- mmkin(
-  c("SFO", "FOMC"),
-  list("FOCUS A" = FOCUS_2006_A,
-       "FOCUS B" = FOCUS_2006_C),
-  quiet = TRUE)
-convergence(fits)
-#>       dataset
-#> model  FOCUS A FOCUS B
-#>   SFO  OK      OK     
-#>   FOMC OK      OK     
-#> 
-#> OK: No warnings
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.6.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/create_deg_func.html b/docs/dev/reference/create_deg_func.html deleted file mode 100644 index fd8325c0..00000000 --- a/docs/dev/reference/create_deg_func.html +++ /dev/null @@ -1,196 +0,0 @@ - -Create degradation functions for known analytical solutions — create_deg_func • mkin - - -
-
- - - -
-
-
-

Create degradation functions for known analytical solutions

- Source: R/create_deg_func.R - -
- -
-

Create degradation functions for known analytical solutions

-
- -
- 
create_deg_func(spec, use_of_ff = c("min", "max"))
-
- -
-

Arguments

-
spec
-

List of model specifications as contained in mkinmod objects

- - -
use_of_ff
-

Minimum or maximum use of formation fractions

- -
-
-

Value

- - -

Degradation function to be attached to mkinmod objects

-
- -
-

Examples

- 

-SFO_SFO <- mkinmod(
-  parent = mkinsub("SFO", "m1"),
-  m1 = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-FOCUS_D <- subset(FOCUS_2006_D, value != 0) # to avoid warnings
-fit_1 <- mkinfit(SFO_SFO, FOCUS_D, solution_type = "analytical", quiet = TRUE)
-# \dontrun{
-fit_2 <- mkinfit(SFO_SFO, FOCUS_D, solution_type = "deSolve", quiet = TRUE)
-if (require(rbenchmark))
-  benchmark(
-    analytical = mkinfit(SFO_SFO, FOCUS_D, solution_type = "analytical", quiet = TRUE),
-    deSolve = mkinfit(SFO_SFO, FOCUS_D, solution_type = "deSolve", quiet = TRUE),
-    replications = 2)
-#> Loading required package: rbenchmark
-#>         test replications elapsed relative user.self sys.self user.child
-#> 1 analytical            2   0.235    1.000     0.235        0          0
-#> 2    deSolve            2   0.294    1.251     0.294        0          0
-#>   sys.child
-#> 1         0
-#> 2         0
-  DFOP_SFO <- mkinmod(
-    parent = mkinsub("DFOP", "m1"),
-    m1 = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-  benchmark(
-    analytical = mkinfit(DFOP_SFO, FOCUS_D, solution_type = "analytical", quiet = TRUE),
-    deSolve = mkinfit(DFOP_SFO, FOCUS_D, solution_type = "deSolve", quiet = TRUE),
-    replications = 2)
-#>         test replications elapsed relative user.self sys.self user.child
-#> 1 analytical            2   0.374    1.000     0.374        0          0
-#> 2    deSolve            2   0.527    1.409     0.526        0          0
-#>   sys.child
-#> 1         0
-#> 2         0
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/dimethenamid_2018-1.png b/docs/dev/reference/dimethenamid_2018-1.png deleted file mode 100644 index 27ed5329..00000000 Binary files a/docs/dev/reference/dimethenamid_2018-1.png and /dev/null differ diff --git a/docs/dev/reference/dimethenamid_2018-2.png b/docs/dev/reference/dimethenamid_2018-2.png deleted file mode 100644 index 36db063c..00000000 Binary files a/docs/dev/reference/dimethenamid_2018-2.png and /dev/null differ diff --git a/docs/dev/reference/dimethenamid_2018-3.png b/docs/dev/reference/dimethenamid_2018-3.png deleted file mode 100644 index 7c876208..00000000 Binary files a/docs/dev/reference/dimethenamid_2018-3.png and /dev/null differ diff --git a/docs/dev/reference/dimethenamid_2018.html b/docs/dev/reference/dimethenamid_2018.html deleted file mode 100644 index 0fcd0c61..00000000 --- a/docs/dev/reference/dimethenamid_2018.html +++ /dev/null @@ -1,390 +0,0 @@ - -Aerobic soil degradation data on dimethenamid and dimethenamid-P from the EU assessment in 2018 — dimethenamid_2018 • mkin - - -
-
- - - -
-
-
-

Aerobic soil degradation data on dimethenamid and dimethenamid-P from the EU assessment in 2018

- Source: R/dimethenamid_2018.R - -
- -
-

The datasets were extracted from the active substance evaluation dossier -published by EFSA. Kinetic evaluations shown for these datasets are intended -to illustrate and advance kinetic modelling. The fact that these data and -some results are shown here does not imply a license to use them in the -context of pesticide registrations, as the use of the data may be -constrained by data protection regulations.

-
- -
- 
dimethenamid_2018
-
- -
-

Format

-

An mkindsg object grouping seven datasets with some meta information

-
-
-

Source

-

Rapporteur Member State Germany, Co-Rapporteur Member State Bulgaria (2018) -Renewal Assessment Report Dimethenamid-P Volume 3 - B.8 Environmental fate and behaviour -Rev. 2 - November 2017 -https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716

-
-
-

Details

-

The R code used to create this data object is installed with this package -in the 'dataset_generation' directory. In the code, page numbers are given for -specific pieces of information in the comments.

-
- -
-

Examples

- 
print(dimethenamid_2018)
-#> <mkindsg> holding 7 mkinds objects
-#> Title $title:  Aerobic soil degradation data on dimethenamid-P from the EU assessment in 2018 
-#> Occurrence of observed compounds $observed_n:
-#> DMTAP   M23   M27   M31  DMTA 
-#>     3     7     7     7     4 
-#> Time normalisation factors $f_time_norm:
-#> [1] 1.0000000 0.9706477 1.2284784 1.2284784 0.6233856 0.7678922 0.6733938
-#> Meta information $meta:
-#>                      study  usda_soil_type study_moisture_ref_type rel_moisture
-#> Calke        Unsworth 2014      Sandy loam                     pF2         1.00
-#> Borstel  Staudenmaier 2009            Sand                     pF1         0.50
-#> Elliot 1        Wendt 1997       Clay loam                   pF2.5         0.75
-#> Elliot 2        Wendt 1997       Clay loam                   pF2.5         0.75
-#> Flaach          König 1996 Sandy clay loam                     pF1         0.40
-#> BBA 2.2         König 1995      Loamy sand                     pF1         0.40
-#> BBA 2.3         König 1995      Sandy loam                     pF1         0.40
-#>          study_ref_moisture temperature
-#> Calke                    NA          20
-#> Borstel               23.00          20
-#> Elliot 1              33.37          23
-#> Elliot 2              33.37          23
-#> Flaach                   NA          20
-#> BBA 2.2                  NA          20
-#> BBA 2.3                  NA          20
-dmta_ds <- lapply(1:7, function(i) {
-  ds_i <- dimethenamid_2018$ds[[i]]$data
-  ds_i[ds_i$name == "DMTAP", "name"] <-  "DMTA"
-  ds_i$time <- ds_i$time * dimethenamid_2018$f_time_norm[i]
-  ds_i
-})
-names(dmta_ds) <- sapply(dimethenamid_2018$ds, function(ds) ds$title)
-dmta_ds[["Elliot"]] <- rbind(dmta_ds[["Elliot 1"]], dmta_ds[["Elliot 2"]])
-dmta_ds[["Elliot 1"]] <- NULL
-dmta_ds[["Elliot 2"]] <- NULL
-# \dontrun{
-# We don't use DFOP for the parent compound, as this gives numerical
-# instabilities in the fits
-sfo_sfo3p <- mkinmod(
- DMTA = mkinsub("SFO", c("M23", "M27", "M31")),
- M23 = mkinsub("SFO"),
- M27 = mkinsub("SFO"),
- M31 = mkinsub("SFO", "M27", sink = FALSE),
- quiet = TRUE
-)
-dmta_sfo_sfo3p_tc <- mmkin(list("SFO-SFO3+" = sfo_sfo3p),
-  dmta_ds, error_model = "tc", quiet = TRUE)
-print(dmta_sfo_sfo3p_tc)
-#> <mmkin> object
-#> Status of individual fits:
-#> 
-#>            dataset
-#> model       Calke Borstel Flaach BBA 2.2 BBA 2.3 Elliot
-#>   SFO-SFO3+ OK    OK      OK     OK      OK      OK    
-#> 
-#> OK: No warnings
-# The default (test_log_parms = FALSE) gives an undue
-# influence of ill-defined rate constants that have
-# extremely small values:
-plot(mixed(dmta_sfo_sfo3p_tc), test_log_parms = FALSE)
-# If we disregards ill-defined rate constants, the results
-# look more plausible, but the truth is likely to be in
-# between these variants
-plot(mixed(dmta_sfo_sfo3p_tc), test_log_parms = TRUE)
-
-# We can also specify a default value for the failing
-# log parameters, to mimic FOCUS guidance
-plot(mixed(dmta_sfo_sfo3p_tc), test_log_parms = TRUE,
-  default_log_parms = log(2)/1000)
-# As these attempts are not satisfying, we use nonlinear mixed-effects models
-# f_dmta_nlme_tc <- nlme(dmta_sfo_sfo3p_tc)
-# nlme reaches maxIter = 50 without convergence
-f_dmta_saem_tc <- saem(dmta_sfo_sfo3p_tc)
-# I am commenting out the convergence plot as rendering them
-# with pkgdown fails (at least without further tweaks to the
-# graphics device used)
-#saemix::plot(f_dmta_saem_tc$so, plot.type = "convergence")
-summary(f_dmta_saem_tc)
-#> saemix version used for fitting:      3.2 
-#> mkin version used for pre-fitting:  1.2.3 
-#> R version used for fitting:         4.2.3 
-#> Date of fit:     Sun Apr 16 08:30:03 2023 
-#> Date of summary: Sun Apr 16 08:30:03 2023 
-#> 
-#> Equations:
-#> d_DMTA/dt = - k_DMTA * DMTA
-#> d_M23/dt = + f_DMTA_to_M23 * k_DMTA * DMTA - k_M23 * M23
-#> d_M27/dt = + f_DMTA_to_M27 * k_DMTA * DMTA - k_M27 * M27 + k_M31 * M31
-#> d_M31/dt = + f_DMTA_to_M31 * k_DMTA * DMTA - k_M31 * M31
-#> 
-#> Data:
-#> 563 observations of 4 variable(s) grouped in 6 datasets
-#> 
-#> Model predictions using solution type deSolve 
-#> 
-#> Fitted in 304.528 s
-#> Using 300, 100 iterations and 9 chains
-#> 
-#> Variance model: Two-component variance function 
-#> 
-#> Starting values for degradation parameters:
-#>       DMTA_0   log_k_DMTA    log_k_M23    log_k_M27    log_k_M31 f_DMTA_ilr_1 
-#>      95.5662      -2.9048      -3.8130      -4.1600      -4.1486       0.1341 
-#> f_DMTA_ilr_2 f_DMTA_ilr_3 
-#>       0.1385      -1.6700 
-#> 
-#> Fixed degradation parameter values:
-#> None
-#> 
-#> Starting values for random effects (square root of initial entries in omega):
-#>              DMTA_0 log_k_DMTA log_k_M23 log_k_M27 log_k_M31 f_DMTA_ilr_1
-#> DMTA_0        4.802     0.0000    0.0000     0.000    0.0000       0.0000
-#> log_k_DMTA    0.000     0.9834    0.0000     0.000    0.0000       0.0000
-#> log_k_M23     0.000     0.0000    0.6983     0.000    0.0000       0.0000
-#> log_k_M27     0.000     0.0000    0.0000     1.028    0.0000       0.0000
-#> log_k_M31     0.000     0.0000    0.0000     0.000    0.9841       0.0000
-#> f_DMTA_ilr_1  0.000     0.0000    0.0000     0.000    0.0000       0.7185
-#> f_DMTA_ilr_2  0.000     0.0000    0.0000     0.000    0.0000       0.0000
-#> f_DMTA_ilr_3  0.000     0.0000    0.0000     0.000    0.0000       0.0000
-#>              f_DMTA_ilr_2 f_DMTA_ilr_3
-#> DMTA_0             0.0000       0.0000
-#> log_k_DMTA         0.0000       0.0000
-#> log_k_M23          0.0000       0.0000
-#> log_k_M27          0.0000       0.0000
-#> log_k_M31          0.0000       0.0000
-#> f_DMTA_ilr_1       0.0000       0.0000
-#> f_DMTA_ilr_2       0.7378       0.0000
-#> f_DMTA_ilr_3       0.0000       0.4451
-#> 
-#> Starting values for error model parameters:
-#> a.1 b.1 
-#>   1   1 
-#> 
-#> Results:
-#> 
-#> Likelihood computed by importance sampling
-#>    AIC  BIC logLik
-#>   2276 2273  -1120
-#> 
-#> Optimised parameters:
-#>                    est.   lower   upper
-#> DMTA_0          88.3192 83.8656 92.7729
-#> log_k_DMTA      -3.0530 -3.5686 -2.5373
-#> log_k_M23       -4.0620 -4.9202 -3.2038
-#> log_k_M27       -3.8633 -4.2668 -3.4598
-#> log_k_M31       -3.9731 -4.4763 -3.4699
-#> f_DMTA_ilr_1     0.1346 -0.2150  0.4841
-#> f_DMTA_ilr_2     0.1449 -0.2593  0.5491
-#> f_DMTA_ilr_3    -1.3882 -1.7011 -1.0753
-#> a.1              0.9156  0.8217  1.0095
-#> b.1              0.1383  0.1216  0.1550
-#> SD.DMTA_0        3.7280 -0.6949  8.1508
-#> SD.log_k_DMTA    0.6431  0.2781  1.0080
-#> SD.log_k_M23     1.0096  0.3782  1.6409
-#> SD.log_k_M27     0.4583  0.1541  0.7625
-#> SD.log_k_M31     0.5738  0.1942  0.9533
-#> SD.f_DMTA_ilr_1  0.4119  0.1528  0.6709
-#> SD.f_DMTA_ilr_2  0.4780  0.1806  0.7754
-#> SD.f_DMTA_ilr_3  0.3657  0.1383  0.5931
-#> 
-#> Correlation: 
-#>              DMTA_0  l__DMTA lg__M23 lg__M27 lg__M31 f_DMTA__1 f_DMTA__2
-#> log_k_DMTA    0.0303                                                    
-#> log_k_M23    -0.0229 -0.0032                                            
-#> log_k_M27    -0.0372 -0.0049  0.0041                                    
-#> log_k_M31    -0.0245 -0.0032  0.0022  0.0815                            
-#> f_DMTA_ilr_1 -0.0046 -0.0006  0.0415 -0.0433  0.0324                    
-#> f_DMTA_ilr_2 -0.0008 -0.0002  0.0214 -0.0267 -0.0893 -0.0361            
-#> f_DMTA_ilr_3 -0.1755 -0.0135  0.0423  0.0775  0.0377 -0.0066    0.0060  
-#> 
-#> Random effects:
-#>                   est.   lower  upper
-#> SD.DMTA_0       3.7280 -0.6949 8.1508
-#> SD.log_k_DMTA   0.6431  0.2781 1.0080
-#> SD.log_k_M23    1.0096  0.3782 1.6409
-#> SD.log_k_M27    0.4583  0.1541 0.7625
-#> SD.log_k_M31    0.5738  0.1942 0.9533
-#> SD.f_DMTA_ilr_1 0.4119  0.1528 0.6709
-#> SD.f_DMTA_ilr_2 0.4780  0.1806 0.7754
-#> SD.f_DMTA_ilr_3 0.3657  0.1383 0.5931
-#> 
-#> Variance model:
-#>       est.  lower upper
-#> a.1 0.9156 0.8217 1.009
-#> b.1 0.1383 0.1216 0.155
-#> 
-#> Backtransformed parameters:
-#>                   est.     lower    upper
-#> DMTA_0        88.31924 83.865625 92.77286
-#> k_DMTA         0.04722  0.028196  0.07908
-#> k_M23          0.01721  0.007298  0.04061
-#> k_M27          0.02100  0.014027  0.03144
-#> k_M31          0.01882  0.011375  0.03112
-#> f_DMTA_to_M23  0.14608        NA       NA
-#> f_DMTA_to_M27  0.12077        NA       NA
-#> f_DMTA_to_M31  0.11123        NA       NA
-#> 
-#> Resulting formation fractions:
-#>               ff
-#> DMTA_M23  0.1461
-#> DMTA_M27  0.1208
-#> DMTA_M31  0.1112
-#> DMTA_sink 0.6219
-#> 
-#> Estimated disappearance times:
-#>       DT50   DT90
-#> DMTA 14.68  48.76
-#> M23  40.27 133.76
-#> M27  33.01 109.65
-#> M31  36.84 122.38
-# As the confidence interval for the random effects of DMTA_0
-# includes zero, we could try an alternative model without
-# such random effects
-# f_dmta_saem_tc_2 <- saem(dmta_sfo_sfo3p_tc,
-#   covariance.model = diag(c(0, rep(1, 7))))
-# saemix::plot(f_dmta_saem_tc_2$so, plot.type = "convergence")
-# This does not perform better judged by AIC and BIC
-# saemix::compare.saemix(f_dmta_saem_tc$so, f_dmta_saem_tc_2$so)
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/ds_mixed-1.png b/docs/dev/reference/ds_mixed-1.png deleted file mode 100644 index d8505ffd..00000000 Binary files a/docs/dev/reference/ds_mixed-1.png and /dev/null differ diff --git a/docs/dev/reference/ds_mixed.html b/docs/dev/reference/ds_mixed.html deleted file mode 100644 index 2d0274ff..00000000 --- a/docs/dev/reference/ds_mixed.html +++ /dev/null @@ -1,257 +0,0 @@ - -Synthetic data for hierarchical kinetic degradation models — ds_mixed • mkin - - -
-
- - - -
-
-
-

Synthetic data for hierarchical kinetic degradation models

- Source: R/ds_mixed.R - -
- -
-

The R code used to create this data object is installed with this package in -the 'dataset_generation' directory.

-
- - - -
-

Examples

- 
# \dontrun{
-  sfo_mmkin <- mmkin("SFO", ds_sfo, quiet = TRUE, error_model = "tc", cores = 15)
-  sfo_saem <- saem(sfo_mmkin, no_random_effect = "parent_0")
-  plot(sfo_saem)
-
-# }
-
-# This is the code used to generate the datasets
-cat(readLines(system.file("dataset_generation/ds_mixed.R", package = "mkin")), sep = "\n")
-#> # Synthetic data for hierarchical kinetic models
-#> # Refactored version of the code previously in tests/testthat/setup_script.R
-#> # The number of datasets was 3 for FOMC, and 10 for HS in that script, now it
-#> # is always 15 for consistency
-#> 
-#> library(mkin)  # We use mkinmod and mkinpredict
-#> sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-#> n <- 15
-#> log_sd <- 0.3
-#> err_1 = list(const = 1, prop = 0.05)
-#> tc <- function(value) sigma_twocomp(value, err_1$const, err_1$prop)
-#> const <- function(value) 2
-#> 
-#> set.seed(123456)
-#> SFO <- mkinmod(parent = mkinsub("SFO"))
-#> sfo_pop <- list(parent_0 = 100, k_parent = 0.03)
-#> sfo_parms <- as.matrix(data.frame(
-#>     k_parent = rlnorm(n, log(sfo_pop$k_parent), log_sd)))
-#> set.seed(123456)
-#> ds_sfo <- lapply(1:n, function(i) {
-#>   ds_mean <- mkinpredict(SFO, sfo_parms[i, ],
-#>     c(parent = sfo_pop$parent_0), sampling_times)
-#>   add_err(ds_mean, tc, n = 1)[[1]]
-#> })
-#> attr(ds_sfo, "pop") <- sfo_pop
-#> attr(ds_sfo, "parms") <- sfo_parms
-#> 
-#> set.seed(123456)
-#> FOMC <- mkinmod(parent = mkinsub("FOMC"))
-#> fomc_pop <- list(parent_0 = 100, alpha = 2, beta = 8)
-#> fomc_parms <- as.matrix(data.frame(
-#>     alpha = rlnorm(n, log(fomc_pop$alpha), 0.4),
-#>     beta = rlnorm(n, log(fomc_pop$beta), 0.2)))
-#> set.seed(123456)
-#> ds_fomc <- lapply(1:n, function(i) {
-#>   ds_mean <- mkinpredict(FOMC, fomc_parms[i, ],
-#>     c(parent = fomc_pop$parent_0), sampling_times)
-#>   add_err(ds_mean, tc, n = 1)[[1]]
-#> })
-#> attr(ds_fomc, "pop") <- fomc_pop
-#> attr(ds_fomc, "parms") <- fomc_parms
-#> 
-#> set.seed(123456)
-#> DFOP <- mkinmod(parent = mkinsub("DFOP"))
-#> dfop_pop <- list(parent_0 = 100, k1 = 0.06, k2 = 0.015, g = 0.4)
-#> dfop_parms <- as.matrix(data.frame(
-#>   k1 = rlnorm(n, log(dfop_pop$k1), log_sd),
-#>   k2 = rlnorm(n, log(dfop_pop$k2), log_sd),
-#>   g = plogis(rnorm(n, qlogis(dfop_pop$g), log_sd))))
-#> set.seed(123456)
-#> ds_dfop <- lapply(1:n, function(i) {
-#>   ds_mean <- mkinpredict(DFOP, dfop_parms[i, ],
-#>     c(parent = dfop_pop$parent_0), sampling_times)
-#>   add_err(ds_mean, tc, n = 1)[[1]]
-#> })
-#> attr(ds_dfop, "pop") <- dfop_pop
-#> attr(ds_dfop, "parms") <- dfop_parms
-#> 
-#> set.seed(123456)
-#> HS <- mkinmod(parent = mkinsub("HS"))
-#> hs_pop <- list(parent_0 = 100, k1 = 0.08, k2 = 0.01, tb = 15)
-#> hs_parms <- as.matrix(data.frame(
-#>   k1 = rlnorm(n, log(hs_pop$k1), log_sd),
-#>   k2 = rlnorm(n, log(hs_pop$k2), log_sd),
-#>   tb = rlnorm(n, log(hs_pop$tb), 0.1)))
-#> set.seed(123456)
-#> ds_hs <- lapply(1:n, function(i) {
-#>   ds_mean <- mkinpredict(HS, hs_parms[i, ],
-#>     c(parent = hs_pop$parent_0), sampling_times)
-#>   add_err(ds_mean, const, n = 1)[[1]]
-#> })
-#> attr(ds_hs, "pop") <- hs_pop
-#> attr(ds_hs, "parms") <- hs_parms
-#> 
-#> set.seed(123456)
-#> DFOP_SFO <- mkinmod(
-#>   parent = mkinsub("DFOP", "m1"),
-#>   m1 = mkinsub("SFO"),
-#>   quiet = TRUE)
-#> dfop_sfo_pop <- list(parent_0 = 100,
-#>   k_m1 = 0.007, f_parent_to_m1 = 0.5,
-#>   k1 = 0.1, k2 = 0.02, g = 0.5)
-#> dfop_sfo_parms <- as.matrix(data.frame(
-#>   k1 = rlnorm(n, log(dfop_sfo_pop$k1), log_sd),
-#>   k2 = rlnorm(n, log(dfop_sfo_pop$k2), log_sd),
-#>   g = plogis(rnorm(n, qlogis(dfop_sfo_pop$g), log_sd)),
-#>   f_parent_to_m1 = plogis(rnorm(n,
-#>       qlogis(dfop_sfo_pop$f_parent_to_m1), log_sd)),
-#>   k_m1 = rlnorm(n, log(dfop_sfo_pop$k_m1), log_sd)))
-#> ds_dfop_sfo_mean <- lapply(1:n,
-#>   function(i) {
-#>     mkinpredict(DFOP_SFO, dfop_sfo_parms[i, ],
-#>       c(parent = dfop_sfo_pop$parent_0, m1 = 0), sampling_times)
-#>   }
-#> )
-#> set.seed(123456)
-#> ds_dfop_sfo <- lapply(ds_dfop_sfo_mean, function(ds) {
-#>   add_err(ds,
-#>     sdfunc = function(value) sqrt(err_1$const^2 + value^2 * err_1$prop^2),
-#>     n = 1, secondary = "m1")[[1]]
-#> })
-#> attr(ds_dfop_sfo, "pop") <- dfop_sfo_pop
-#> attr(ds_dfop_sfo, "parms") <- dfop_sfo_parms
-#> 
-#> #save(ds_sfo, ds_fomc, ds_dfop, ds_hs, ds_dfop_sfo, file = "data/ds_mixed.rda", version = 2)
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/endpoints.html b/docs/dev/reference/endpoints.html deleted file mode 100644 index 3cda0f3c..00000000 --- a/docs/dev/reference/endpoints.html +++ /dev/null @@ -1,228 +0,0 @@ - -Function to calculate endpoints for further use from kinetic models fitted -with mkinfit — endpoints • mkin - - -
-
- - - -
-
-
-

Function to calculate endpoints for further use from kinetic models fitted -with mkinfit

- Source: R/endpoints.R - -
- -
-

This function calculates DT50 and DT90 values as well as formation fractions -from kinetic models fitted with mkinfit. If the SFORB model was specified -for one of the parents or metabolites, the Eigenvalues are returned. These -are equivalent to the rate constants of the DFOP model, but with the -advantage that the SFORB model can also be used for metabolites.

-
- -
- 
endpoints(fit, covariates = NULL, covariate_quantile = 0.5)
-
- -
-

Arguments

-
fit
-

An object of class mkinfit, nlme.mmkin or saem.mmkin, or -another object that has list components mkinmod containing an mkinmod -degradation model, and two numeric vectors, bparms.optim and bparms.fixed, -that contain parameter values for that model.

- - -
covariates
-

Numeric vector with covariate values for all variables in -any covariate models in the object. If given, it overrides 'covariate_quantile'.

- - -
covariate_quantile
-

This argument only has an effect if the fitted -object has covariate models. If so, the default is to show endpoints -for the median of the covariate values (50th percentile).

- -
-
-

Value

- - -

A list with a matrix of dissipation times named distimes, and, if -applicable, a vector of formation fractions named ff and, if the SFORB model -was in use, a vector of eigenvalues of these SFORB models, equivalent to -DFOP rate constants

-
-
-

Details

-

Additional DT50 values are calculated from the FOMC DT90 and k1 and k2 from -HS and DFOP, as well as from Eigenvalues b1 and b2 of any SFORB models

-
-
-

Note

-

The function is used internally by summary.mkinfit, -summary.nlme.mmkin and summary.saem.mmkin.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-  fit <- mkinfit("FOMC", FOCUS_2006_C, quiet = TRUE)
-  endpoints(fit)
-#> $distimes
-#>            DT50    DT90 DT50back
-#> parent 1.785233 15.1479 4.559973
-#> 
-  # \dontrun{
-    fit_2 <- mkinfit("DFOP", FOCUS_2006_C, quiet = TRUE)
-    endpoints(fit_2)
-#> $distimes
-#>            DT50     DT90 DT50back  DT50_k1  DT50_k2
-#> parent 1.886925 21.25106 6.397207 1.508293 38.83438
-#> 
-    fit_3 <- mkinfit("SFORB", FOCUS_2006_C, quiet = TRUE)
-    endpoints(fit_3)
-#> $ff
-#> parent_free 
-#>           1 
-#> 
-#> $SFORB
-#> parent_b1 parent_b2  parent_g 
-#> 0.4595574 0.0178488 0.8539454 
-#> 
-#> $distimes
-#>            DT50     DT90 DT50back DT50_parent_b1 DT50_parent_b2
-#> parent 1.886925 21.25106 6.397208       1.508293       38.83438
-#> 
-  # }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/example_analysis/dlls/sforb_sfo2.so b/docs/dev/reference/example_analysis/dlls/sforb_sfo2.so deleted file mode 100755 index a692256d..00000000 Binary files a/docs/dev/reference/example_analysis/dlls/sforb_sfo2.so and /dev/null differ diff --git a/docs/dev/reference/example_analysis/example_analysis.Rmd b/docs/dev/reference/example_analysis/example_analysis.Rmd deleted file mode 100644 index 38a6bd20..00000000 --- a/docs/dev/reference/example_analysis/example_analysis.Rmd +++ /dev/null @@ -1,314 +0,0 @@ ---- -title: "Hierarchical kinetic modelling of degradation data" -author: -date: -output: mkin::hierarchical_kinetics -geometry: margin=2cm ---- - -\clearpage - -# Setup - -```{r packages, cache = FALSE, message = FALSE} -library(mkin) -library(knitr) -library(saemix) -library(parallel) -library(readxl) -``` - -```{r n_cores, cache = FALSE} -n_cores <- detectCores() - -if (Sys.info()["sysname"] == "Windows") { - cl <- makePSOCKcluster(n_cores) -} else { - cl <- makeForkCluster(n_cores) -} -``` - -\clearpage - -# Introduction - -This report shows hierarchical kinetic modelling for ... -The data were obtained from ... - -```{r ds} -data_path <- system.file( - "testdata", "lambda-cyhalothrin_soil_efsa_2014.xlsx", - package = "mkin") -ds <- read_spreadsheet(data_path, valid_datasets = c(1:4, 7:13)) -covariates <- attr(ds, "covariates") -``` - -The covariate data are shown below. - -```{r results = "asis", dependson = "ds", echo = FALSE} -kable(covariates, caption = "Covariate data for all datasets") -``` - -\clearpage - -The datasets with the residue time series are shown in the tables below. Please -refer to the spreadsheet for details like data sources, treatment of values -below reporting limits and time step normalisation factors. - -```{r results = "asis", dependson = "ds", echo = FALSE} -for (ds_name in names(ds)) { - print( - kable(mkin_long_to_wide(ds[[ds_name]]), - caption = paste("Dataset", ds_name), - booktabs = TRUE, row.names = FALSE)) - cat("\n\\clearpage\n") -} -``` - -# Parent only evaluations - -The following code performs separate fits of the candidate degradation models -to all datasets using constant variance and the two-component error model. - -```{r parent-sep, dependson = "ds"} -parent_deg_mods <- c("SFO", "FOMC", "DFOP", "SFORB") -errmods <- c(const = "constant variance", tc = "two-component error") -parent_sep_const <- mmkin( - parent_deg_mods, ds, - error_model = "const", - cluster = cl, quiet = TRUE) -parent_sep_tc <- update(parent_sep_const, error_model = "tc") -``` - -To select the parent model, the corresponding hierarchical fits are performed below. - -```{r parent-mhmkin, dependson = "parent-sep"} -parent_mhmkin <- mhmkin(list(parent_sep_const, parent_sep_tc), cluster = cl) -status(parent_mhmkin) |> kable() -``` - -All fits terminate without errors (status OK). The check for ill-defined -parameters shows that not all random effect parameters can be robustly -quantified. - -```{r dependson = "parent_mhmkin"} -illparms(parent_mhmkin) |> kable() -``` - -Therefore, the fits are updated, excluding random effects that were -ill-defined according to the `illparms` function. The status of the fits -is checked. - -```{r parent-mhmkin-refined} -parent_mhmkin_refined <- update(parent_mhmkin, - no_random_effect = illparms(parent_mhmkin)) -status(parent_mhmkin_refined) |> kable() -``` - -Also, it is checked if the AIC values of the refined fits are actually smaller -than the AIC values of the original fits. - -```{r dependson = "parent-mhmkin-refined"} -(AIC(parent_mhmkin_refined) < AIC(parent_mhmkin)) |> kable() -``` - -From the refined fits, the most suitable model is selected using the AIC. - -```{r parent-best, dependson = "parent-mhmkin"} -aic_parent <- AIC(parent_mhmkin_refined) -min_aic <- which(aic_parent == min(aic_parent), arr.ind = TRUE) -best_degmod_parent <- rownames(aic_parent)[min_aic[1]] -best_errmod_parent <- colnames(aic_parent)[min_aic[2]] -anova(parent_mhmkin_refined) |> kable(digits = 1) -parent_best <- parent_mhmkin_refined[[best_degmod_parent, best_errmod_parent]] -``` - -Based on the AIC, the combination of the `r best_degmod_parent` degradation -model with the error model `r errmods[best_errmod_parent]` is identified to -be most suitable for the degradation of the parent. The check below -confirms that no ill-defined parameters remain for this combined model. - -```{r dependson = "parent-best"} -illparms(parent_best) -``` - -The corresponding fit is plotted below. - -```{r dependson = "parent-best"} -plot(parent_best) -``` -The fitted parameters, together with approximate confidence -intervals are listed below. - -```{r dependson = "parent-best"} -parms(parent_best, ci = TRUE) |> kable(digits = 3) -``` - -To investigate a potential covariate influence on degradation parameters, a -covariate model is added to the hierarchical model for each of the degradation -parameters with well-defined random effects. Also, a version with covariate -models for both of them is fitted. - -```{r parent-best-pH} -parent_best_pH_1 <- update(parent_best, covariates = covariates, - covariate_models = list(log_k_lambda_free ~ pH)) -parent_best_pH_2 <- update(parent_best, covariates = covariates, - covariate_models = list(log_k_lambda_bound_free ~ pH)) -parent_best_pH_3 <- update(parent_best, covariates = covariates, - covariate_models = list(log_k_lambda_free ~ pH, log_k_lambda_bound_free ~ pH)) -``` - -The resulting models are compared. - -```{r dependson = "parent-best-pH"} -anova(parent_best, parent_best_pH_1, parent_best_pH_2, parent_best_pH_3) |> - kable(digits = 1) -``` - -The model fit with the lowest AIC is the one with a pH correlation of the -desorption rate constant `k_lambda_bound_free`. Plot and parameter listing -of this fit are shown below. Also, it is confirmed that no ill-defined -variance parameters are found. - -```{r dependson = "parent-best-pH"} -plot(parent_best_pH_2) -``` - -```{r dependson = "parent-best-pH"} -illparms(parent_best_pH_2) -parms(parent_best_pH_2, ci = TRUE) |> kable(digits = 3) -``` - -\clearpage - -# Pathway fits - -As an example of a pathway fit, a model with SFORB for the parent compound and -parallel formation of two metabolites is set up. - -```{r path-1-degmod} -if (!dir.exists("dlls")) dir.create("dlls") - -m_sforb_sfo2 = mkinmod( - lambda = mkinsub("SFORB", to = c("c_V", "c_XV")), - c_V = mkinsub("SFO"), - c_XV = mkinsub("SFO"), - name = "sforb_sfo2", - dll_dir = "dlls", - overwrite = TRUE, quiet = TRUE -) -``` - -Separate evaluations of all datasets are performed with constant variance -and using two-component error. - -```{r path-1-sep, dependson = c("path-1-degmod", "ds")} -sforb_sep_const <- mmkin(list(sforb_path = m_sforb_sfo2), ds, - cluster = cl, quiet = TRUE) -sforb_sep_tc <- update(sforb_sep_const, error_model = "tc") -``` - -The separate fits with constant variance are plotted. - -```{r dependson = "path-1-sep", fig.height = 9} -plot(mixed(sforb_sep_const)) -``` - -The two corresponding hierarchical fits, with the random effects for the parent -degradation parameters excluded as discussed above, and including the covariate -model that was identified for the parent degradation, are attempted below. - -```{r path-1, dependson = "path-1-sep"} -path_1 <- mhmkin(list(sforb_sep_const, sforb_sep_tc), - no_random_effect = c("lambda_free_0", "log_k_lambda_free_bound"), - covariates = covariates, covariate_models = list(log_k_lambda_bound_free ~ pH), - cluster = cl) -``` - -```{r dependson = "path-1"} -status(path_1) |> kable() -``` - -The status information shows that both fits were successfully completed. - -```{r dependson = "path-1"} -anova(path_1) |> kable(digits = 1) -``` -Model comparison shows that the two-component error model provides a much -better fit. - -```{r dependson = "path-1"} -illparms(path_1[["sforb_path", "tc"]]) -``` - -Two ill-defined variance components are found. Therefore, the fit is -repeated with the corresponding random effects removed. - -```{r path-1-refined, dependson = "path-1"} -path_1_refined <- update(path_1[["sforb_path", "tc"]], - no_random_effect = c("lambda_free_0", "log_k_lambda_free_bound", - "log_k_c_XV", "f_lambda_ilr_2")) -``` - -The empty output of the illparms function indicates that there are no -ill-defined parameters remaining in the refined fit. - -```{r dependson = "path-1-refined"} -illparms(path_1_refined) -``` - -Below, the refined fit is plotted and the fitted parameters are shown together -with their 95% confidence intervals. - -```{r dependson = "path-1-refined", fig.height = 9} -plot(path_1_refined) -``` - -```{r dependson = "path-1-refined", fig.height = 9} -parms(path_1_refined, ci = TRUE) |> kable(digits = 3) -``` - -\clearpage - -# Appendix - -## Listings of initial parent fits - -```{r listings-parent, results = "asis", echo = FALSE, dependson = "parent_mhmkin"} -for (deg_mod in parent_deg_mods) { - for (err_mod in c("const", "tc")) { - caption <- paste("Hierarchical", deg_mod, "fit with", errmods[err_mod]) - tex_listing(parent_mhmkin[[deg_mod, err_mod]], caption) - } -} -``` - -## Listings of refined parent fits - -```{r listings-parent-refined, results = "asis", echo = FALSE, dependson = "parent_mhmkin_refined"} -for (deg_mod in parent_deg_mods) { - for (err_mod in c("const", "tc")) { - caption <- paste("Refined hierarchical", deg_mod, "fit with", errmods[err_mod]) - tex_listing(parent_mhmkin_refined[[deg_mod, err_mod]], caption) - } -} -``` - -## Listings of pathway fits - -```{r listings-path-1, results = "asis", echo = FALSE, dependson = "path-1-refined"} -tex_listing(path_1[["sforb_path", "const"]], - caption = "Hierarchical fit of SFORB-SFO2 with constant variance") -tex_listing(path_1[["sforb_path", "tc"]], - caption = "Hierarchical fit of SFORB-SFO2 with two-component error") -tex_listing(path_1_refined, - caption = "Refined hierarchical fit of SFORB-SFO2 with two-component error") -``` - -## Session info - -```{r echo = FALSE, cache = FALSE} -parallel::stopCluster(cl) -sessionInfo() -``` - diff --git a/docs/dev/reference/example_analysis/header.tex b/docs/dev/reference/example_analysis/header.tex deleted file mode 100644 index a2b7ce83..00000000 --- a/docs/dev/reference/example_analysis/header.tex +++ /dev/null @@ -1 +0,0 @@ -\definecolor{shadecolor}{RGB}{248,248,248} diff --git a/docs/dev/reference/example_analysis/skeleton.pdf b/docs/dev/reference/example_analysis/skeleton.pdf deleted file mode 100644 index 53c5fb31..00000000 Binary files a/docs/dev/reference/example_analysis/skeleton.pdf and /dev/null differ diff --git a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-11-1.pdf b/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-11-1.pdf deleted file mode 100644 index ab685d92..00000000 Binary files a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-11-1.pdf and /dev/null differ diff --git a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-16-1.pdf b/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-16-1.pdf deleted file mode 100644 index 5d88063b..00000000 Binary files a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-16-1.pdf and /dev/null differ diff --git a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-6-1.pdf b/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-6-1.pdf deleted file mode 100644 index 5e0d7b6f..00000000 Binary files a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-6-1.pdf and /dev/null differ diff --git a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-9-1.pdf b/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-9-1.pdf deleted file mode 100644 index eecd06a8..00000000 Binary files a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-9-1.pdf and /dev/null differ diff --git a/docs/dev/reference/experimental_data_for_UBA-1.png b/docs/dev/reference/experimental_data_for_UBA-1.png deleted file mode 100644 index 49e1c6c9..00000000 Binary files a/docs/dev/reference/experimental_data_for_UBA-1.png and /dev/null differ diff --git a/docs/dev/reference/experimental_data_for_UBA.html b/docs/dev/reference/experimental_data_for_UBA.html deleted file mode 100644 index 77ff6ce4..00000000 --- a/docs/dev/reference/experimental_data_for_UBA.html +++ /dev/null @@ -1,275 +0,0 @@ - -Experimental datasets used for development and testing of error models — experimental_data_for_UBA_2019 • mkin - - -
-
- - - -
-
-
-

Experimental datasets used for development and testing of error models

- - -
- -
-

The 12 datasets were extracted from active substance evaluation dossiers published - by EFSA. Kinetic evaluations shown for these datasets are intended to illustrate - and advance error model specifications. The fact that these data and some - results are shown here do not imply a license to use them in the context of - pesticide registrations, as the use of the data may be constrained by - data protection regulations.

-

Preprocessing of data was performed based on the recommendations of the FOCUS - kinetics workgroup (FOCUS, 2014) as described below.

-

Datasets 1 and 2 are from the Renewal Assessment Report (RAR) for imazamox - (France, 2015, p. 15). For setting values reported as zero, an LOQ of 0.1 - was assumed. Metabolite residues reported for day zero were added to the - parent compound residues.

-

Datasets 3 and 4 are from the Renewal Assessment Report (RAR) for isofetamid - (Belgium, 2014, p. 8) and show the data for two different radiolabels. For - dataset 4, the value given for the metabolite in the day zero sampling - in replicate B was added to the parent compound, following the respective - FOCUS recommendation.

-

Dataset 5 is from the Renewal Assessment Report (RAR) for ethofumesate - (Austria, 2015, p. 16).

-

Datasets 6 to 10 are from the Renewal Assessment Report (RAR) for glyphosate - (Germany, 2013, pages 8, 28, 50, 51). For the initial sampling, - the residues given for the metabolite were added to the parent - value, following the recommendation of the FOCUS kinetics workgroup.

-

Dataset 11 is from the Renewal Assessment Report (RAR) for 2,4-D - (Hellas, 2013, p. 644). Values reported as zero were set to NA, with - the exception of the day three sampling of metabolite A2, which was set - to one half of the LOD reported to be 1% AR.

-

Dataset 12 is from the Renewal Assessment Report (RAR) for thifensulfuron-methyl - (United Kingdom, 2014, p. 81).

-
- -
- 
experimental_data_for_UBA_2019
-
- -
-

Format

-

A list containing twelve datasets as an R6 class defined by mkinds, - each containing, among others, the following components

title
-

The name of the dataset, e.g. Soil 1

- -
data
-

A data frame with the data in the form expected by mkinfit

- - -
-
-

Source

- - -

Austria (2015). Ethofumesate Renewal Assessment Report Volume 3 Annex B.8 (AS)

-

Belgium (2014). Isofetamid (IKF-5411) Draft Assessment Report Volume 3 Annex B.8 (AS)

-

France (2015). Imazamox Draft Renewal Assessment Report Volume 3 Annex B.8 (AS)

-

FOCUS (2014) “Generic guidance for Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - Version 1.1, 18 December 2014 - http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-

Germany (2013). Renewal Assessment Report Glyphosate Volume 3 Annex B.8: Environmental Fate - and Behaviour

-

Hellas (2013). Renewal Assessment Report 2,4-D Volume 3 Annex B.8: Fate and behaviour in the - environment

-

Ranke (2019) Documentation of results obtained for the error model expertise - written for the German Umweltbundesamt.

-

United Kingdom (2014). Thifensulfuron-methyl - Annex B.8 (Volume 3) to the Report and Proposed - Decision of the United Kingdom made to the European Commission under Regulation (EC) No. - 1141/2010 for renewal of an active substance

-
- -
-

Examples

- 
# \dontrun{
-
-# Model definitions
-sfo_sfo <- mkinmod(
-  parent = mkinsub("SFO", to = "A1"),
-  A1 = mkinsub("SFO"),
-  use_of_ff = "max"
-)
-#> Temporary DLL for differentials generated and loaded
-
-dfop_sfo <- mkinmod(
-  parent = mkinsub("DFOP", to = "A1"),
-  A1 = mkinsub("SFO"),
-  use_of_ff = "max"
-)
-#> Temporary DLL for differentials generated and loaded
-
-sfo_sfo_sfo <- mkinmod(
-  parent = mkinsub("SFO", to = "A1"),
-  A1 = mkinsub("SFO", to = "A2"),
-  A2 = mkinsub("SFO"),
-  use_of_ff = "max"
-)
-#> Temporary DLL for differentials generated and loaded
-
-dfop_sfo_sfo <- mkinmod(
-  parent = mkinsub("DFOP", to = "A1"),
-  A1 = mkinsub("SFO", to = "A2"),
-  A2 = mkinsub("SFO"),
-  use_of_ff = "max"
-)
-#> Temporary DLL for differentials generated and loaded
-d_1_2 <- lapply(experimental_data_for_UBA_2019[1:2], function(x) x$data)
-names(d_1_2) <- paste("Soil", 1:2)
-
-
-f_1_2_tc <- mmkin(list("DFOP-SFO-SFO" = dfop_sfo_sfo), d_1_2, error_model = "tc")
-
-plot(f_1_2_tc, resplot = "errmod")
-
-
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/f_time_norm_focus.html b/docs/dev/reference/f_time_norm_focus.html deleted file mode 100644 index b0722bc6..00000000 --- a/docs/dev/reference/f_time_norm_focus.html +++ /dev/null @@ -1,248 +0,0 @@ - -Normalisation factors for aerobic soil degradation according to FOCUS guidance — f_time_norm_focus • mkin - - -
-
- - - -
-
-
-

Normalisation factors for aerobic soil degradation according to FOCUS guidance

- Source: R/f_time_norm_focus.R - -
- -
-

Time step normalisation factors for aerobic soil degradation as described -in Appendix 8 to the FOCUS kinetics guidance (FOCUS 2014, p. 369).

-
- -
- 
f_time_norm_focus(object, ...)
-
-# S3 method for numeric
-f_time_norm_focus(
-  object,
-  moisture = NA,
-  field_moisture = NA,
-  temperature = object,
-  Q10 = 2.58,
-  walker = 0.7,
-  f_na = NA,
-  ...
-)
-
-# S3 method for mkindsg
-f_time_norm_focus(
-  object,
-  study_moisture_ref_source = c("auto", "meta", "focus"),
-  Q10 = 2.58,
-  walker = 0.7,
-  f_na = NA,
-  ...
-)
-
- -
-

Arguments

-
object
-

An object containing information used for the calculations

- - -
...
-

Currently not used

- - -
moisture
-

Numeric vector of moisture contents in \% w/w

- - -
field_moisture
-

Numeric vector of moisture contents at field capacity -(pF2) in \% w/w

- - -
temperature
-

Numeric vector of temperatures in °C

- - -
Q10
-

The Q10 value used for temperature normalisation

- - -
walker
-

The Walker exponent used for moisture normalisation

- - -
f_na
-

The factor to use for NA values. If set to NA, only factors -for complete cases will be returned.

- - -
study_moisture_ref_source
-

Source for the reference value -used to calculate the study moisture. If 'auto', preference is given -to a reference moisture given in the meta information, otherwise -the focus soil moisture for the soil class is used

- -
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
-
-

See also

-

focus_soil_moisture

-
- -
-

Examples

- 
f_time_norm_focus(25, 20, 25) # 1.37, compare FOCUS 2014 p. 184
-#> [1] 1.373956
-
-D24_2014$meta
-#>                                 study usda_soil_type study_moisture_ref_type
-#> Mississippi                Cohen 1991      Silt loam                    <NA>
-#> Fayette     Liu and Adelfinskaya 2011      Silt loam                     pF1
-#> RefSol 03-G Liu and Adelfinskaya 2011           Loam                     pF1
-#> Site E1     Liu and Adelfinskaya 2011           Loam                     pF1
-#> Site I2     Liu and Adelfinskaya 2011     Loamy sand                     pF1
-#>             rel_moisture temperature
-#> Mississippi           NA          25
-#> Fayette              0.5          20
-#> RefSol 03-G          0.5          20
-#> Site E1              0.5          20
-#> Site I2              0.5          20
-# No moisture normalisation in the first dataset, so we use f_na = 1 to get
-# temperature only normalisation as in the EU evaluation
-f_time_norm_focus(D24_2014, study_moisture_ref_source = "focus", f_na = 1)
-#> $f_time_norm was (re)set to normalised values
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/focus_soil_moisture.html b/docs/dev/reference/focus_soil_moisture.html deleted file mode 100644 index cb4a035a..00000000 --- a/docs/dev/reference/focus_soil_moisture.html +++ /dev/null @@ -1,170 +0,0 @@ - -FOCUS default values for soil moisture contents at field capacity, MWHC and 1/3 bar — focus_soil_moisture • mkin - - -
-
- - - -
-
-
-

FOCUS default values for soil moisture contents at field capacity, MWHC and 1/3 bar

- Source: R/focus_soil_moisture.R - -
- -
-

The value were transcribed from p. 36. The table assumes field capacity -corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5.

-
- -
- 
focus_soil_moisture
-
- -
-

Format

-

A matrix with upper case USDA soil classes as row names, and water tension -('pF1', 'pF2', 'pF 2.5') as column names

-
-
-

Source

-

Anonymous (2014) Generic Guidance for Tier 1 FOCUS Ground Water Assessment -Version 2.2, May 2014 https://esdac.jrc.ec.europa.eu/projects/ground-water

-
- -
-

Examples

- 
focus_soil_moisture
-#>                 pF1 pF2 pF2.5
-#> Sand             24  12     7
-#> Loamy sand       24  14     9
-#> Sandy loam       27  19    15
-#> Sandy clay loam  28  22    18
-#> Clay loam        32  28    25
-#> Loam             31  25    21
-#> Silt loam        32  26    21
-#> Silty clay loam  34  30    27
-#> Silt             31  27    21
-#> Sandy clay       41  35    31
-#> Silty clay       44  40    36
-#> Clay             53  48    43
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/get_deg_func.html b/docs/dev/reference/get_deg_func.html deleted file mode 100644 index cf81a591..00000000 --- a/docs/dev/reference/get_deg_func.html +++ /dev/null @@ -1,147 +0,0 @@ - -Retrieve a degradation function from the mmkin namespace — get_deg_func • mkin - - -
-
- - - -
-
-
-

Retrieve a degradation function from the mmkin namespace

- Source: R/nlme.mmkin.R - -
- -
-

Retrieve a degradation function from the mmkin namespace

-
- -
- 
get_deg_func()
-
- -
-

Value

- - -

A function that was likely previously assigned from within -nlme.mmkin

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/hierarchical_kinetics.html b/docs/dev/reference/hierarchical_kinetics.html deleted file mode 100644 index 7ece90cc..00000000 --- a/docs/dev/reference/hierarchical_kinetics.html +++ /dev/null @@ -1,197 +0,0 @@ - -Hierarchical kinetics template — hierarchical_kinetics • mkin - - -
-
- - - -
-
-
-

Hierarchical kinetics template

- Source: R/hierarchical_kinetics.R - -
- -
-

R markdown format for setting up hierarchical kinetics based on a template -provided with the mkin package. This format is based on rmarkdown::pdf_document. -Chunk options are adapted. Echoing R code from code chunks and caching are -turned on per default. character for prepending output from code chunks is -set to the empty string, code tidying is off, figure alignment defaults to -centering, and positioning of figures is set to "H", which means that -figures will not move around in the document, but stay where the user -includes them.

-
- -
- 
hierarchical_kinetics(..., keep_tex = FALSE)
-
- -
-

Arguments

-
...
-

Arguments to rmarkdown::pdf_document

- - -
keep_tex
-

Keep the intermediate tex file used in the conversion to PDF

- -
-
-

Value

- - -

R Markdown output format to pass to -render

- - -
-
-

Details

-

The latter feature (positioning the figures with "H") depends on the LaTeX -package 'float'. In addition, the LaTeX package 'listing' is used in the -template for showing model fit summaries in the Appendix. This means that -the LaTeX packages 'float' and 'listing' need to be installed in the TeX -distribution used.

-

On Windows, the easiest way to achieve this (if no TeX distribution -is present before) is to install the 'tinytex' R package, to run -'tinytex::install_tinytex()' to get the basic tiny Tex distribution, -and then to run 'tinytex::tlmgr_install(c("float", "listing"))'.

-
- -
-

Examples

- 

-# \dontrun{
-library(rmarkdown)
-# The following is now commented out after the relase of v1.2.3 for the generation
-# of online docs, as the command creates a directory and opens an editor
-#draft("example_analysis.rmd", template = "hierarchical_kinetics", package = "mkin")
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/illparms.html b/docs/dev/reference/illparms.html deleted file mode 100644 index 7bf6c1fe..00000000 --- a/docs/dev/reference/illparms.html +++ /dev/null @@ -1,253 +0,0 @@ - -Method to get the names of ill-defined parameters — illparms • mkin - - -
-
- - - -
-
-
-

Method to get the names of ill-defined parameters

- Source: R/illparms.R - -
- -
-

The method for generalised nonlinear regression fits as obtained -with mkinfit and mmkin checks if the degradation parameters -pass the Wald test (in degradation kinetics often simply called t-test) for -significant difference from zero. For this test, the parameterisation -without parameter transformations is used.

-
- -
- 
illparms(object, ...)
-
-# S3 method for mkinfit
-illparms(object, conf.level = 0.95, ...)
-
-# S3 method for illparms.mkinfit
-print(x, ...)
-
-# S3 method for mmkin
-illparms(object, conf.level = 0.95, ...)
-
-# S3 method for illparms.mmkin
-print(x, ...)
-
-# S3 method for saem.mmkin
-illparms(
-  object,
-  conf.level = 0.95,
-  random = TRUE,
-  errmod = TRUE,
-  slopes = TRUE,
-  ...
-)
-
-# S3 method for illparms.saem.mmkin
-print(x, ...)
-
-# S3 method for mhmkin
-illparms(object, conf.level = 0.95, random = TRUE, errmod = TRUE, ...)
-
-# S3 method for illparms.mhmkin
-print(x, ...)
-
- -
-

Arguments

-
object
-

The object to investigate

- - -
...
-

For potential future extensions

- - -
conf.level
-

The confidence level for checking p values

- - -
x
-

The object to be printed

- - -
random
-

For hierarchical fits, should random effects be tested?

- - -
errmod
-

For hierarchical fits, should error model parameters be -tested?

- - -
slopes
-

For hierarchical saem fits using saemix as backend, -should slope parameters in the covariate model(starting with 'beta_') be -tested?

- -
-
-

Value

- - -

For mkinfit or saem objects, a character vector of parameter -names. For mmkin or mhmkin objects, a matrix like object of class -'illparms.mmkin' or 'illparms.mhmkin'.

-
-
-

Details

-

The method for hierarchical model fits, also known as nonlinear -mixed-effects model fits as obtained with saem and mhmkin -checks if any of the confidence intervals for the random -effects expressed as standard deviations include zero, and if -the confidence intervals for the error model parameters include -zero.

-
-
-

Note

-

All return objects have printing methods. For the single fits, printing -does not output anything in the case no ill-defined parameters are found.

-
- -
-

Examples

- 
fit <- mkinfit("FOMC", FOCUS_2006_A, quiet = TRUE)
-illparms(fit)
-#> [1] "parent_0" "alpha"    "beta"     "sigma"   
-# \dontrun{
-fits <- mmkin(
-  c("SFO", "FOMC"),
-  list("FOCUS A" = FOCUS_2006_A,
-       "FOCUS C" = FOCUS_2006_C),
-  quiet = TRUE)
-illparms(fits)
-#>       dataset
-#> model  FOCUS A                      FOCUS C
-#>   SFO                                      
-#>   FOMC parent_0, alpha, beta, sigma        
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/ilr.html b/docs/dev/reference/ilr.html deleted file mode 100644 index 94b23a76..00000000 --- a/docs/dev/reference/ilr.html +++ /dev/null @@ -1,210 +0,0 @@ - -Function to perform isometric log-ratio transformation — ilr • mkin - - -
-
- - - -
-
-
-

Function to perform isometric log-ratio transformation

- Source: R/ilr.R - -
- -
-

This implementation is a special case of the class of isometric log-ratio -transformations.

-
- -
- 
ilr(x)
-
-invilr(x)
-
- -
-

Arguments

-
x
-

A numeric vector. Naturally, the forward transformation is only -sensible for vectors with all elements being greater than zero.

- -
-
-

Value

- - -

The result of the forward or backward transformation. The returned -components always sum to 1 for the case of the inverse log-ratio -transformation.

-
-
-

References

-

Peter Filzmoser, Karel Hron (2008) Outlier Detection for -Compositional Data Using Robust Methods. Math Geosci 40 233-248

-
-
-

See also

-

Another implementation can be found in R package -robCompositions.

-
-
-

Author

-

René Lehmann and Johannes Ranke

-
- -
-

Examples

- 

-# Order matters
-ilr(c(0.1, 1, 10))
-#> [1] -1.628174 -2.820079
-ilr(c(10, 1, 0.1))
-#> [1] 1.628174 2.820079
-# Equal entries give ilr transformations with zeros as elements
-ilr(c(3, 3, 3))
-#> [1] 0 0
-# Almost equal entries give small numbers
-ilr(c(0.3, 0.4, 0.3))
-#> [1] -0.2034219  0.1174457
-# Only the ratio between the numbers counts, not their sum
-invilr(ilr(c(0.7, 0.29, 0.01)))
-#> [1] 0.70 0.29 0.01
-invilr(ilr(2.1 * c(0.7, 0.29, 0.01)))
-#> [1] 0.70 0.29 0.01
-# Inverse transformation of larger numbers gives unequal elements
-invilr(-10)
-#> [1] 7.213536e-07 9.999993e-01
-invilr(c(-10, 0))
-#> [1] 7.207415e-07 9.991507e-01 8.486044e-04
-# The sum of the elements of the inverse ilr is 1
-sum(invilr(c(-10, 0)))
-#> [1] 1
-# This is why we do not need all elements of the inverse transformation to go back:
-a <- c(0.1, 0.3, 0.5)
-b <- invilr(a)
-length(b) # Four elements
-#> [1] 4
-ilr(c(b[1:3], 1 - sum(b[1:3]))) # Gives c(0.1, 0.3, 0.5)
-#> [1] 0.1 0.3 0.5
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/index.html b/docs/dev/reference/index.html deleted file mode 100644 index d1b789c3..00000000 --- a/docs/dev/reference/index.html +++ /dev/null @@ -1,528 +0,0 @@ - -Function reference • mkin - - -
-
- - - -
-
-
-

Reference

-
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
-

Main functions

-

Essential functionality

-
-

mkinmod() print(<mkinmod>) mkinsub()

-

Function to set up a kinetic model with one or more state variables

-

mkinfit()

-

Fit a kinetic model to data with one or more state variables

-

mmkin() print(<mmkin>)

-

Fit one or more kinetic models with one or more state variables to one or -more datasets

-

mhmkin() `[`(<mhmkin>) print(<mhmkin>)

-

Fit nonlinear mixed-effects models built from one or more kinetic -degradation models and one or more error models

-

Generics

-

Generic functions introduced by the package

-
-

parms()

-

Extract model parameters

-

status() print(<status.mmkin>) print(<status.mhmkin>)

-

Method to get status information for fit array objects

-

illparms() print(<illparms.mkinfit>) print(<illparms.mmkin>) print(<illparms.saem.mmkin>) print(<illparms.mhmkin>)

-

Method to get the names of ill-defined parameters

-

endpoints()

-

Function to calculate endpoints for further use from kinetic models fitted -with mkinfit

-

aw()

-

Calculate Akaike weights for model averaging

-

Show results

-

Functions working with mkinfit objects

-
-

plot(<mkinfit>) plot_sep() plot_res() plot_err()

-

Plot the observed data and the fitted model of an mkinfit object

-

summary(<mkinfit>) print(<summary.mkinfit>)

-

Summary method for class "mkinfit"

-

confint(<mkinfit>)

-

Confidence intervals for parameters of mkinfit objects

-

update(<mkinfit>)

-

Update an mkinfit model with different arguments

-

lrtest(<mkinfit>) lrtest(<mmkin>)

-

Likelihood ratio test for mkinfit models

-

loftest()

-

Lack-of-fit test for models fitted to data with replicates

-

mkinerrmin()

-

Calculate the minimum error to assume in order to pass the variance test

-

CAKE_export()

-

Export a list of datasets format to a CAKE study file

-

Work with mmkin objects

-

Functions working with aggregated results

-
-

`[`(<mmkin>)

-

Subsetting method for mmkin objects

-

plot(<mmkin>)

-

Plot model fits (observed and fitted) and the residuals for a row or column -of an mmkin object

-

AIC(<mmkin>) BIC(<mmkin>)

-

Calculate the AIC for a column of an mmkin object

-

summary(<mmkin>) print(<summary.mmkin>)

-

Summary method for class "mmkin"

-

Mixed models

-

Create and work with nonlinear hierarchical models

-
-

hierarchical_kinetics()

-

Hierarchical kinetics template

-

read_spreadsheet()

-

Read datasets and relevant meta information from a spreadsheet file

-

nlme(<mmkin>) print(<nlme.mmkin>) update(<nlme.mmkin>)

-

Create an nlme model for an mmkin row object

-

saem() print(<saem.mmkin>) saemix_model() saemix_data()

-

Fit nonlinear mixed models with SAEM

-

mhmkin() `[`(<mhmkin>) print(<mhmkin>)

-

Fit nonlinear mixed-effects models built from one or more kinetic -degradation models and one or more error models

-

plot(<mixed.mmkin>)

-

Plot predictions from a fitted nonlinear mixed model obtained via an mmkin row object

-

summary(<nlme.mmkin>) print(<summary.nlme.mmkin>)

-

Summary method for class "nlme.mmkin"

-

summary(<saem.mmkin>) print(<summary.saem.mmkin>)

-

Summary method for class "saem.mmkin"

-

anova(<saem.mmkin>)

-

Anova method for saem.mmkin objects

-

logLik(<saem.mmkin>)

-

logLik method for saem.mmkin objects

-

nlme_function() nlme_data()

-

Helper functions to create nlme models from mmkin row objects

-

get_deg_func()

-

Retrieve a degradation function from the mmkin namespace

-

mixed() print(<mixed.mmkin>)

-

Create a mixed effects model from an mmkin row object

-

reexports intervals lrtest nlme

-

Objects exported from other packages

-

intervals(<saem.mmkin>)

-

Confidence intervals for parameters in saem.mmkin objects

-

multistart() print(<multistart>) best() which.best()

-

Perform a hierarchical model fit with multiple starting values

-

llhist()

-

Plot the distribution of log likelihoods from multistart objects

-

parplot()

-

Plot parameter variability of multistart objects

-

Datasets and known results

-

-
-

ds_mixed ds_sfo ds_fomc ds_dfop ds_hs ds_dfop_sfo

-

Synthetic data for hierarchical kinetic degradation models

-

D24_2014

-

Aerobic soil degradation data on 2,4-D from the EU assessment in 2014

-

dimethenamid_2018

-

Aerobic soil degradation data on dimethenamid and dimethenamid-P from the EU assessment in 2018

-

FOCUS_2006_A FOCUS_2006_B FOCUS_2006_C FOCUS_2006_D FOCUS_2006_E FOCUS_2006_F

-

Datasets A to F from the FOCUS Kinetics report from 2006

-

FOCUS_2006_SFO_ref_A_to_F

-

Results of fitting the SFO model to Datasets A to F of FOCUS (2006)

-

FOCUS_2006_FOMC_ref_A_to_F

-

Results of fitting the FOMC model to Datasets A to F of FOCUS (2006)

-

FOCUS_2006_HS_ref_A_to_F

-

Results of fitting the HS model to Datasets A to F of FOCUS (2006)

-

FOCUS_2006_DFOP_ref_A_to_B

-

Results of fitting the DFOP model to Datasets A to B of FOCUS (2006)

-

NAFTA_SOP_Appendix_B NAFTA_SOP_Appendix_D

-

Example datasets from the NAFTA SOP published 2015

-

NAFTA_SOP_Attachment

-

Example datasets from Attachment 1 to the NAFTA SOP published 2015

-

mccall81_245T

-

Datasets on aerobic soil metabolism of 2,4,5-T in six soils

-

schaefer07_complex_case

-

Metabolism data set used for checking the software quality of KinGUI

-

synthetic_data_for_UBA_2014

-

Synthetic datasets for one parent compound with two metabolites

-

experimental_data_for_UBA_2019

-

Experimental datasets used for development and testing of error models

-

test_data_from_UBA_2014

-

Three experimental datasets from two water sediment systems and one soil

-

focus_soil_moisture

-

FOCUS default values for soil moisture contents at field capacity, MWHC and 1/3 bar

-

print(<mkinds>)

-

A dataset class for mkin

-

print(<mkindsg>)

-

A class for dataset groups for mkin

-

NAFTA guidance

-

-
-

nafta() print(<nafta>)

-

Evaluate parent kinetics using the NAFTA guidance

-

plot(<nafta>)

-

Plot the results of the three models used in the NAFTA scheme.

-

Utility functions

-

-
-

summary_listing() tex_listing() html_listing()

-

Display the output of a summary function according to the output format

-

f_time_norm_focus()

-

Normalisation factors for aerobic soil degradation according to FOCUS guidance

-

set_nd_nq() set_nd_nq_focus()

-

Set non-detects and unquantified values in residue series without replicates

-

max_twa_parent() max_twa_sfo() max_twa_fomc() max_twa_dfop() max_twa_hs()

-

Function to calculate maximum time weighted average concentrations from -kinetic models fitted with mkinfit

-

mkin_wide_to_long()

-

Convert a dataframe with observations over time into long format

-

mkin_long_to_wide()

-

Convert a dataframe from long to wide format

-

Helper functions mainly used internally

-

-
-

mkinpredict()

-

Produce predictions from a kinetic model using specific parameters

-

transform_odeparms() backtransform_odeparms()

-

Functions to transform and backtransform kinetic parameters for fitting

-

ilr() invilr()

-

Function to perform isometric log-ratio transformation

-

logLik(<mkinfit>)

-

Calculated the log-likelihood of a fitted mkinfit object

-

residuals(<mkinfit>)

-

Extract residuals from an mkinfit model

-

nobs(<mkinfit>)

-

Number of observations on which an mkinfit object was fitted

-

mkinresplot()

-

Function to plot residuals stored in an mkin object

-

mkinparplot()

-

Function to plot the confidence intervals obtained using mkinfit

-

mkinerrplot()

-

Function to plot squared residuals and the error model for an mkin object

-

mean_degparms()

-

Calculate mean degradation parameters for an mmkin row object

-

create_deg_func()

-

Create degradation functions for known analytical solutions

-

Analytical solutions

-

Parent only model solutions

-
-

SFO.solution()

-

Single First-Order kinetics

-

FOMC.solution()

-

First-Order Multi-Compartment kinetics

-

DFOP.solution()

-

Double First-Order in Parallel kinetics

-

SFORB.solution()

-

Single First-Order Reversible Binding kinetics

-

HS.solution()

-

Hockey-Stick kinetics

-

IORE.solution()

-

Indeterminate order rate equation kinetics

-

logistic.solution()

-

Logistic kinetics

-

Generate synthetic datasets

-

-
-

add_err()

-

Add normally distributed errors to simulated kinetic degradation data

-

sigma_twocomp()

-

Two-component error model

-

Deprecated functions

-

Functions that have been superseded

-
-

mkinplot()

-

Plot the observed data and the fitted model of an mkinfit object

- - -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/intervals.nlmixr.mmkin.html b/docs/dev/reference/intervals.nlmixr.mmkin.html deleted file mode 100644 index 14f11c0c..00000000 --- a/docs/dev/reference/intervals.nlmixr.mmkin.html +++ /dev/null @@ -1,132 +0,0 @@ - -Confidence intervals for parameters in nlmixr.mmkin objects — intervals.nlmixr.mmkin • mkin - - -
-
- - - -
-
-
-

Confidence intervals for parameters in nlmixr.mmkin objects

- Source: R/intervals.R - -
- -
-

Confidence intervals for parameters in nlmixr.mmkin objects

-
- -
- 
# S3 method for nlmixr.mmkin
-intervals(object, level = 0.95, backtransform = TRUE, ...)
-
- -
-

Arguments

-
object
-

The fitted saem.mmkin object

-
level
-

The confidence level.

-
backtransform
-

Should we backtransform the parameters where a one to -one correlation between transformed and backtransformed parameters exists?

-
...
-

For compatibility with the generic method

-
-
-

Value

-

An object with 'intervals.saem.mmkin' and 'intervals.lme' in the -class attribute

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.2.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/intervals.saem.mmkin.html b/docs/dev/reference/intervals.saem.mmkin.html deleted file mode 100644 index a566ee8d..00000000 --- a/docs/dev/reference/intervals.saem.mmkin.html +++ /dev/null @@ -1,169 +0,0 @@ - -Confidence intervals for parameters in saem.mmkin objects — intervals.saem.mmkin • mkin - - -
-
- - - -
-
-
-

Confidence intervals for parameters in saem.mmkin objects

- Source: R/intervals.R - -
- -
-

Confidence intervals for parameters in saem.mmkin objects

-
- -
- 
# S3 method for saem.mmkin
-intervals(object, level = 0.95, backtransform = TRUE, ...)
-
- -
-

Arguments

-
object
-

The fitted saem.mmkin object

- - -
level
-

The confidence level. Must be the default of 0.95 as this is what -is available in the saemix object

- - -
backtransform
-

In case the model was fitted with mkin transformations, -should we backtransform the parameters where a one to one correlation -between transformed and backtransformed parameters exists?

- - -
...
-

For compatibility with the generic method

- -
-
-

Value

- - -

An object with 'intervals.saem.mmkin' and 'intervals.lme' in the -class attribute

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/llhist.html b/docs/dev/reference/llhist.html deleted file mode 100644 index 2b5afa25..00000000 --- a/docs/dev/reference/llhist.html +++ /dev/null @@ -1,168 +0,0 @@ - -Plot the distribution of log likelihoods from multistart objects — llhist • mkin - - -
-
- - - -
-
-
-

Plot the distribution of log likelihoods from multistart objects

- Source: R/llhist.R - -
- -
-

Produces a histogram of log-likelihoods. In addition, the likelihood of the -original fit is shown as a red vertical line.

-
- -
- 
llhist(object, breaks = "Sturges", lpos = "topleft", main = "", ...)
-
- -
-

Arguments

-
object
-

The multistart object

- - -
breaks
-

Passed to hist

- - -
lpos
-

Positioning of the legend.

- - -
main
-

Title of the plot

- - -
...
-

Passed to hist

- -
-
-

See also

-

multistart

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/loftest-1.png b/docs/dev/reference/loftest-1.png deleted file mode 100644 index 750a2acf..00000000 Binary files a/docs/dev/reference/loftest-1.png and /dev/null differ diff --git a/docs/dev/reference/loftest-2.png b/docs/dev/reference/loftest-2.png deleted file mode 100644 index d12c26e7..00000000 Binary files a/docs/dev/reference/loftest-2.png and /dev/null differ diff --git a/docs/dev/reference/loftest-3.png b/docs/dev/reference/loftest-3.png deleted file mode 100644 index 9f45c74d..00000000 Binary files a/docs/dev/reference/loftest-3.png and /dev/null differ diff --git a/docs/dev/reference/loftest-4.png b/docs/dev/reference/loftest-4.png deleted file mode 100644 index 3beb9d1a..00000000 Binary files a/docs/dev/reference/loftest-4.png and /dev/null differ diff --git a/docs/dev/reference/loftest-5.png b/docs/dev/reference/loftest-5.png deleted file mode 100644 index 1a3aaeea..00000000 Binary files a/docs/dev/reference/loftest-5.png and /dev/null differ diff --git a/docs/dev/reference/loftest.html b/docs/dev/reference/loftest.html deleted file mode 100644 index 871dfc88..00000000 --- a/docs/dev/reference/loftest.html +++ /dev/null @@ -1,342 +0,0 @@ - -Lack-of-fit test for models fitted to data with replicates — loftest • mkin - - -
-
- - - -
-
-
-

Lack-of-fit test for models fitted to data with replicates

- Source: R/loftest.R - -
- -
-

This is a generic function with a method currently only defined for mkinfit -objects. It fits an anova model to the data contained in the object and -compares the likelihoods using the likelihood ratio test -lrtest.default from the lmtest package.

-
- -
- 
loftest(object, ...)
-
-# S3 method for mkinfit
-loftest(object, ...)
-
- -
-

Arguments

-
object
-

A model object with a defined loftest method

- - -
...
-

Not used

- -
-
-

Details

-

The anova model is interpreted as the simplest form of an mkinfit model, -assuming only a constant variance about the means, but not enforcing any -structure of the means, so we have one model parameter for every mean -of replicate samples.

-
-
-

See also

-

lrtest

-
- -
-

Examples

- 
# \dontrun{
-test_data <- subset(synthetic_data_for_UBA_2014[[12]]$data, name == "parent")
-sfo_fit <- mkinfit("SFO", test_data, quiet = TRUE)
-plot_res(sfo_fit) # We see a clear pattern in the residuals
-
-loftest(sfo_fit)  # We have a clear lack of fit
-#> Likelihood ratio test
-#> 
-#> Model 1: ANOVA with error model const
-#> Model 2: SFO with error model const
-#>   #Df  LogLik Df  Chisq Pr(>Chisq)    
-#> 1  10 -40.710                         
-#> 2   3 -63.954 -7 46.487  7.027e-08 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-#
-# We try a different model (the one that was used to generate the data)
-dfop_fit <- mkinfit("DFOP", test_data, quiet = TRUE)
-plot_res(dfop_fit) # We don't see systematic deviations, but heteroscedastic residuals
-
-# therefore we should consider adapting the error model, although we have
-loftest(dfop_fit) # no lack of fit
-#> Likelihood ratio test
-#> 
-#> Model 1: ANOVA with error model const
-#> Model 2: DFOP with error model const
-#>   #Df  LogLik Df Chisq Pr(>Chisq)
-#> 1  10 -40.710                    
-#> 2   5 -42.453 -5 3.485     0.6257
-#
-# This is the anova model used internally for the comparison
-test_data_anova <- test_data
-test_data_anova$time <- as.factor(test_data_anova$time)
-anova_fit <- lm(value ~ time, data = test_data_anova)
-summary(anova_fit)
-#> 
-#> Call:
-#> lm(formula = value ~ time, data = test_data_anova)
-#> 
-#> Residuals:
-#>     Min      1Q  Median      3Q     Max 
-#> -6.1000 -0.5625  0.0000  0.5625  6.1000 
-#> 
-#> Coefficients:
-#>             Estimate Std. Error t value Pr(>|t|)    
-#> (Intercept)  103.150      2.323  44.409 7.44e-12 ***
-#> time1        -19.950      3.285  -6.073 0.000185 ***
-#> time3        -50.800      3.285 -15.465 8.65e-08 ***
-#> time7        -68.500      3.285 -20.854 6.28e-09 ***
-#> time14       -79.750      3.285 -24.278 1.63e-09 ***
-#> time28       -86.000      3.285 -26.181 8.35e-10 ***
-#> time60       -94.900      3.285 -28.891 3.48e-10 ***
-#> time90       -98.500      3.285 -29.986 2.49e-10 ***
-#> time120     -100.450      3.285 -30.580 2.09e-10 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-#> 
-#> Residual standard error: 3.285 on 9 degrees of freedom
-#> Multiple R-squared:  0.9953,	Adjusted R-squared:  0.9912 
-#> F-statistic: 240.5 on 8 and 9 DF,  p-value: 1.417e-09
-#> 
-logLik(anova_fit) # We get the same likelihood and degrees of freedom
-#> 'log Lik.' -40.71015 (df=10)
-#
-test_data_2 <- synthetic_data_for_UBA_2014[[12]]$data
-m_synth_SFO_lin <- mkinmod(parent = list(type = "SFO", to = "M1"),
-  M1 = list(type = "SFO", to = "M2"),
-  M2 = list(type = "SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-sfo_lin_fit <- mkinfit(m_synth_SFO_lin, test_data_2, quiet = TRUE)
-plot_res(sfo_lin_fit) # not a good model, we try parallel formation
-
-loftest(sfo_lin_fit)
-#> Likelihood ratio test
-#> 
-#> Model 1: ANOVA with error model const
-#> Model 2: m_synth_SFO_lin with error model const and fixed parameter(s) M1_0, M2_0
-#>   #Df   LogLik  Df  Chisq Pr(>Chisq)    
-#> 1  28  -93.606                          
-#> 2   7 -171.927 -21 156.64  < 2.2e-16 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-#
-m_synth_SFO_par <- mkinmod(parent = list(type = "SFO", to = c("M1", "M2")),
-  M1 = list(type = "SFO"),
-  M2 = list(type = "SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-sfo_par_fit <- mkinfit(m_synth_SFO_par, test_data_2, quiet = TRUE)
-plot_res(sfo_par_fit) # much better for metabolites
-
-loftest(sfo_par_fit)
-#> Likelihood ratio test
-#> 
-#> Model 1: ANOVA with error model const
-#> Model 2: m_synth_SFO_par with error model const and fixed parameter(s) M1_0, M2_0
-#>   #Df   LogLik  Df  Chisq Pr(>Chisq)    
-#> 1  28  -93.606                          
-#> 2   7 -156.331 -21 125.45  < 2.2e-16 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-#
-m_synth_DFOP_par <- mkinmod(parent = list(type = "DFOP", to = c("M1", "M2")),
-  M1 = list(type = "SFO"),
-  M2 = list(type = "SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-dfop_par_fit <- mkinfit(m_synth_DFOP_par, test_data_2, quiet = TRUE)
-plot_res(dfop_par_fit) # No visual lack of fit
-
-loftest(dfop_par_fit)  # no lack of fit found by the test
-#> Likelihood ratio test
-#> 
-#> Model 1: ANOVA with error model const
-#> Model 2: m_synth_DFOP_par with error model const and fixed parameter(s) M1_0, M2_0
-#>   #Df   LogLik  Df  Chisq Pr(>Chisq)
-#> 1  28  -93.606                      
-#> 2   9 -102.763 -19 18.313     0.5016
-#
-# The anova model used for comparison in the case of transformation products
-test_data_anova_2 <- dfop_par_fit$data
-test_data_anova_2$variable <- as.factor(test_data_anova_2$variable)
-test_data_anova_2$time <- as.factor(test_data_anova_2$time)
-anova_fit_2 <- lm(observed ~ time:variable - 1, data = test_data_anova_2)
-summary(anova_fit_2)
-#> 
-#> Call:
-#> lm(formula = observed ~ time:variable - 1, data = test_data_anova_2)
-#> 
-#> Residuals:
-#>     Min      1Q  Median      3Q     Max 
-#> -6.1000 -0.5875  0.0000  0.5875  6.1000 
-#> 
-#> Coefficients: (2 not defined because of singularities)
-#>                        Estimate Std. Error t value Pr(>|t|)    
-#> time0:variableparent    103.150      1.573  65.562  < 2e-16 ***
-#> time1:variableparent     83.200      1.573  52.882  < 2e-16 ***
-#> time3:variableparent     52.350      1.573  33.274  < 2e-16 ***
-#> time7:variableparent     34.650      1.573  22.024  < 2e-16 ***
-#> time14:variableparent    23.400      1.573  14.873 6.35e-14 ***
-#> time28:variableparent    17.150      1.573  10.901 5.47e-11 ***
-#> time60:variableparent     8.250      1.573   5.244 1.99e-05 ***
-#> time90:variableparent     4.650      1.573   2.956 0.006717 ** 
-#> time120:variableparent    2.700      1.573   1.716 0.098507 .  
-#> time0:variableM1             NA         NA      NA       NA    
-#> time1:variableM1         11.850      1.573   7.532 6.93e-08 ***
-#> time3:variableM1         22.700      1.573  14.428 1.26e-13 ***
-#> time7:variableM1         33.050      1.573  21.007  < 2e-16 ***
-#> time14:variableM1        31.250      1.573  19.863  < 2e-16 ***
-#> time28:variableM1        18.900      1.573  12.013 7.02e-12 ***
-#> time60:variableM1         7.550      1.573   4.799 6.28e-05 ***
-#> time90:variableM1         3.850      1.573   2.447 0.021772 *  
-#> time120:variableM1        2.050      1.573   1.303 0.204454    
-#> time0:variableM2             NA         NA      NA       NA    
-#> time1:variableM2          6.700      1.573   4.259 0.000254 ***
-#> time3:variableM2         16.750      1.573  10.646 8.93e-11 ***
-#> time7:variableM2         25.800      1.573  16.399 6.89e-15 ***
-#> time14:variableM2        28.600      1.573  18.178 6.35e-16 ***
-#> time28:variableM2        25.400      1.573  16.144 9.85e-15 ***
-#> time60:variableM2        21.600      1.573  13.729 3.81e-13 ***
-#> time90:variableM2        17.800      1.573  11.314 2.51e-11 ***
-#> time120:variableM2       14.100      1.573   8.962 2.79e-09 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-#> 
-#> Residual standard error: 2.225 on 25 degrees of freedom
-#> Multiple R-squared:  0.9979,	Adjusted R-squared:  0.9957 
-#> F-statistic: 469.2 on 25 and 25 DF,  p-value: < 2.2e-16
-#> 
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/logLik.mkinfit.html b/docs/dev/reference/logLik.mkinfit.html deleted file mode 100644 index e51a52eb..00000000 --- a/docs/dev/reference/logLik.mkinfit.html +++ /dev/null @@ -1,204 +0,0 @@ - -Calculated the log-likelihood of a fitted mkinfit object — logLik.mkinfit • mkin - - -
-
- - - -
-
-
-

Calculated the log-likelihood of a fitted mkinfit object

- Source: R/logLik.mkinfit.R - -
- -
-

This function returns the product of the likelihood densities of each -observed value, as calculated as part of the fitting procedure using -dnorm, i.e. assuming normal distribution, and with the means -predicted by the degradation model, and the standard deviations predicted by -the error model.

-
- -
- 
# S3 method for mkinfit
-logLik(object, ...)
-
- -
-

Arguments

-
object
-

An object of class mkinfit.

- - -
...
-

For compatibility with the generic method

- -
-
-

Value

- - -

An object of class logLik with the number of estimated -parameters (degradation model parameters plus variance model parameters) -as attribute.

-
-
-

Details

-

The total number of estimated parameters returned with the value of the -likelihood is calculated as the sum of fitted degradation model parameters -and the fitted error model parameters.

-
-
-

See also

-

Compare the AIC of columns of mmkin objects using -AIC.mmkin.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-  # \dontrun{
-  sfo_sfo <- mkinmod(
-    parent = mkinsub("SFO", to = "m1"),
-    m1 = mkinsub("SFO")
-  )
-#> Temporary DLL for differentials generated and loaded
-  d_t <- subset(FOCUS_2006_D, value != 0)
-  f_nw <- mkinfit(sfo_sfo, d_t, quiet = TRUE) # no weighting (weights are unity)
-  f_obs <- update(f_nw, error_model = "obs")
-  f_tc <- update(f_nw, error_model = "tc")
-  AIC(f_nw, f_obs, f_tc)
-#>       df      AIC
-#> f_nw   5 204.4486
-#> f_obs  6 205.8727
-#> f_tc   6 141.9656
-  # }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/logLik.saem.mmkin.html b/docs/dev/reference/logLik.saem.mmkin.html deleted file mode 100644 index 6d0102c1..00000000 --- a/docs/dev/reference/logLik.saem.mmkin.html +++ /dev/null @@ -1,155 +0,0 @@ - -logLik method for saem.mmkin objects — logLik.saem.mmkin • mkin - - -
-
- - - -
-
-
-

logLik method for saem.mmkin objects

- Source: R/saem.R - -
- -
-

logLik method for saem.mmkin objects

-
- -
- 
# S3 method for saem.mmkin
-logLik(object, ..., method = c("is", "lin", "gq"))
-
- -
-

Arguments

-
object
-

The fitted saem.mmkin object

- - -
...
-

Passed to saemix::logLik.SaemixObject

- - -
method
-

Passed to saemix::logLik.SaemixObject

- -
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/logistic.solution-1.png b/docs/dev/reference/logistic.solution-1.png deleted file mode 100644 index 23c031de..00000000 Binary files a/docs/dev/reference/logistic.solution-1.png and /dev/null differ diff --git a/docs/dev/reference/logistic.solution-2.png b/docs/dev/reference/logistic.solution-2.png deleted file mode 100644 index b56db0cb..00000000 Binary files a/docs/dev/reference/logistic.solution-2.png and /dev/null differ diff --git a/docs/dev/reference/logistic.solution.html b/docs/dev/reference/logistic.solution.html deleted file mode 100644 index 9cfebf03..00000000 --- a/docs/dev/reference/logistic.solution.html +++ /dev/null @@ -1,253 +0,0 @@ - -Logistic kinetics — logistic.solution • mkin - - -
-
- - - -
-
-
-

Logistic kinetics

- Source: R/parent_solutions.R - -
- -
-

Function describing exponential decline from a defined starting value, with -an increasing rate constant, supposedly caused by microbial growth

-
- -
- 
logistic.solution(t, parent_0, kmax, k0, r)
-
- -
-

Arguments

-
t
-

Time.

- - -
parent_0
-

Starting value for the response variable at time zero.

- - -
kmax
-

Maximum rate constant.

- - -
k0
-

Minimum rate constant effective at time zero.

- - -
r
-

Growth rate of the increase in the rate constant.

- -
-
-

Value

- - -

The value of the response variable at time t.

-
-
-

Note

-

The solution of the logistic model reduces to the -SFO.solution if k0 is equal to kmax.

-
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
-
-

See also

-

Other parent solutions: -DFOP.solution(), -FOMC.solution(), -HS.solution(), -IORE.solution(), -SFO.solution(), -SFORB.solution()

-
- -
-

Examples

- 

-  # Reproduce the plot on page 57 of FOCUS (2014)
-  plot(function(x) logistic.solution(x, 100, 0.08, 0.0001, 0.2),
-       from = 0, to = 100, ylim = c(0, 100),
-       xlab = "Time", ylab = "Residue")
-  plot(function(x) logistic.solution(x, 100, 0.08, 0.0001, 0.4),
-       from = 0, to = 100, add = TRUE, lty = 2, col = 2)
-  plot(function(x) logistic.solution(x, 100, 0.08, 0.0001, 0.8),
-       from = 0, to = 100, add = TRUE, lty = 3, col = 3)
-  plot(function(x) logistic.solution(x, 100, 0.08, 0.001, 0.2),
-       from = 0, to = 100, add = TRUE, lty = 4, col = 4)
-  plot(function(x) logistic.solution(x, 100, 0.08, 0.08, 0.2),
-       from = 0, to = 100, add = TRUE, lty = 5, col = 5)
-  legend("topright", inset = 0.05,
-         legend = paste0("k0 = ", c(0.0001, 0.0001, 0.0001, 0.001, 0.08),
-                         ", r = ", c(0.2, 0.4, 0.8, 0.2, 0.2)),
-         lty = 1:5, col = 1:5)
-
-
-  # Fit with synthetic data
-  logistic <- mkinmod(parent = mkinsub("logistic"))
-
-  sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-  parms_logistic <- c(kmax = 0.08, k0 = 0.0001, r = 0.2)
-  d_logistic <- mkinpredict(logistic,
-    parms_logistic, c(parent = 100),
-    sampling_times)
-  d_2_1 <- add_err(d_logistic,
-    sdfunc = function(x) sigma_twocomp(x, 0.5, 0.07),
-    n = 1, reps = 2, digits = 5, LOD = 0.1, seed = 123456)[[1]]
-
-  m <- mkinfit("logistic", d_2_1, quiet = TRUE)
-  plot_sep(m)
-
-  summary(m)$bpar
-#>              Estimate   se_notrans   t value       Pr(>t)        Lower
-#> parent_0 1.057896e+02 1.9023449590 55.610120 3.768360e-16 1.016451e+02
-#> kmax     6.398190e-02 0.0143201029  4.467978 3.841828e-04 3.929235e-02
-#> k0       1.612775e-04 0.0005866813  0.274898 3.940351e-01 5.846688e-08
-#> r        2.263946e-01 0.1718110662  1.317695 1.061043e-01 4.335843e-02
-#> sigma    5.332935e+00 0.9145907310  5.830952 4.036926e-05 3.340213e+00
-#>                Upper
-#> parent_0 109.9341588
-#> kmax       0.1041853
-#> k0         0.4448749
-#> r          1.1821120
-#> sigma      7.3256566
-  endpoints(m)$distimes
-#>            DT50     DT90  DT50_k0 DT50_kmax
-#> parent 36.86533 62.41511 4297.853  10.83349
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/lrtest.mkinfit.html b/docs/dev/reference/lrtest.mkinfit.html deleted file mode 100644 index d59590c0..00000000 --- a/docs/dev/reference/lrtest.mkinfit.html +++ /dev/null @@ -1,233 +0,0 @@ - -Likelihood ratio test for mkinfit models — lrtest.mkinfit • mkin - - -
-
- - - -
-
-
-

Likelihood ratio test for mkinfit models

- Source: R/lrtest.mkinfit.R - -
- -
-

Compare two mkinfit models based on their likelihood. If two fitted -mkinfit objects are given as arguments, it is checked if they have been -fitted to the same data. It is the responsibility of the user to make sure -that the models are nested, i.e. one of them has less degrees of freedom -and can be expressed by fixing the parameters of the other.

-
- -
- 
# S3 method for mkinfit
-lrtest(object, object_2 = NULL, ...)
-
-# S3 method for mmkin
-lrtest(object, ...)
-
- -
-

Arguments

-
object
-

An mkinfit object, or an mmkin column -object containing two fits to the same data.

- - -
object_2
-

Optionally, another mkinfit object fitted to the same data.

- - -
...
-

Argument to mkinfit, passed to -update.mkinfit for creating the alternative fitted object.

- -
-
-

Details

-

Alternatively, an argument to mkinfit can be given which is then passed -to update.mkinfit to obtain the alternative model.

-

The comparison is then made by the lrtest.default -method from the lmtest package. The model with the higher number of fitted -parameters (alternative hypothesis) is listed first, then the model with the -lower number of fitted parameters (null hypothesis).

-
- -
-

Examples

- 
# \dontrun{
-test_data <- subset(synthetic_data_for_UBA_2014[[12]]$data, name == "parent")
-sfo_fit <- mkinfit("SFO", test_data, quiet = TRUE)
-dfop_fit <- mkinfit("DFOP", test_data, quiet = TRUE)
-lrtest(dfop_fit, sfo_fit)
-#> Likelihood ratio test
-#> 
-#> Model 1: DFOP with error model const
-#> Model 2: SFO with error model const
-#>   #Df  LogLik Df  Chisq Pr(>Chisq)    
-#> 1   5 -42.453                         
-#> 2   3 -63.954 -2 43.002  4.594e-10 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-lrtest(sfo_fit, dfop_fit)
-#> Likelihood ratio test
-#> 
-#> Model 1: DFOP with error model const
-#> Model 2: SFO with error model const
-#>   #Df  LogLik Df  Chisq Pr(>Chisq)    
-#> 1   5 -42.453                         
-#> 2   3 -63.954 -2 43.002  4.594e-10 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-
-# The following two examples are commented out as they fail during
-# generation of the static help pages by pkgdown
-#lrtest(dfop_fit, error_model = "tc")
-#lrtest(dfop_fit, fixed_parms = c(k2 = 0))
-
-# However, this equivalent syntax also works for static help pages
-lrtest(dfop_fit, update(dfop_fit, error_model = "tc"))
-#> Likelihood ratio test
-#> 
-#> Model 1: DFOP with error model tc
-#> Model 2: DFOP with error model const
-#>   #Df  LogLik Df  Chisq Pr(>Chisq)    
-#> 1   6 -34.587                         
-#> 2   5 -42.453 -1 15.731  7.302e-05 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-lrtest(dfop_fit, update(dfop_fit, fixed_parms = c(k2 = 0)))
-#> Likelihood ratio test
-#> 
-#> Model 1: DFOP with error model const
-#> Model 2: DFOP with error model const and fixed parameter(s) k2
-#>   #Df  LogLik Df  Chisq Pr(>Chisq)    
-#> 1   5 -42.453                         
-#> 2   4 -57.340 -1 29.776  4.851e-08 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/max_twa_parent.html b/docs/dev/reference/max_twa_parent.html deleted file mode 100644 index 507a0758..00000000 --- a/docs/dev/reference/max_twa_parent.html +++ /dev/null @@ -1,239 +0,0 @@ - -Function to calculate maximum time weighted average concentrations from -kinetic models fitted with mkinfit — max_twa_parent • mkin - - -
-
- - - -
-
-
-

Function to calculate maximum time weighted average concentrations from -kinetic models fitted with mkinfit

- Source: R/max_twa_parent.R - -
- -
-

This function calculates maximum moving window time weighted average -concentrations (TWAs) for kinetic models fitted with mkinfit. -Currently, only calculations for the parent are implemented for the SFO, -FOMC, DFOP and HS models, using the analytical formulas given in the PEC -soil section of the FOCUS guidance.

-
- -
- 
max_twa_parent(fit, windows)
-
-max_twa_sfo(M0 = 1, k, t)
-
-max_twa_fomc(M0 = 1, alpha, beta, t)
-
-max_twa_dfop(M0 = 1, k1, k2, g, t)
-
-max_twa_hs(M0 = 1, k1, k2, tb, t)
-
- -
-

Arguments

-
fit
-

An object of class mkinfit.

- - -
windows
-

The width of the time windows for which the TWAs should be -calculated.

- - -
M0
-

The initial concentration for which the maximum time weighted -average over the decline curve should be calculated. The default is to use -a value of 1, which means that a relative maximum time weighted average -factor (f_twa) is calculated.

- - -
k
-

The rate constant in the case of SFO kinetics.

- - -
t
-

The width of the time window.

- - -
alpha
-

Parameter of the FOMC model.

- - -
beta
-

Parameter of the FOMC model.

- - -
k1
-

The first rate constant of the DFOP or the HS kinetics.

- - -
k2
-

The second rate constant of the DFOP or the HS kinetics.

- - -
g
-

Parameter of the DFOP model.

- - -
tb
-

Parameter of the HS model.

- -
-
-

Value

- - -

For max_twa_parent, a numeric vector, named using the -windows argument. For the other functions, a numeric vector of -length one (also known as 'a number').

-
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-  fit <- mkinfit("FOMC", FOCUS_2006_C, quiet = TRUE)
-  max_twa_parent(fit, c(7, 21))
-#>        7       21 
-#> 34.71343 18.22124 
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mccall81_245T-1.png b/docs/dev/reference/mccall81_245T-1.png deleted file mode 100644 index 5e4ea6ef..00000000 Binary files a/docs/dev/reference/mccall81_245T-1.png and /dev/null differ diff --git a/docs/dev/reference/mccall81_245T.html b/docs/dev/reference/mccall81_245T.html deleted file mode 100644 index c0e9cb37..00000000 --- a/docs/dev/reference/mccall81_245T.html +++ /dev/null @@ -1,247 +0,0 @@ - -Datasets on aerobic soil metabolism of 2,4,5-T in six soils — mccall81_245T • mkin - - -
-
- - - -
-
-
-

Datasets on aerobic soil metabolism of 2,4,5-T in six soils

- - -
- -
-

Time course of 2,4,5-trichlorophenoxyacetic acid, and the corresponding - 2,4,5-trichlorophenol and 2,4,5-trichloroanisole as recovered in diethylether - extracts.

-
- -
- 
mccall81_245T
-
- -
-

Format

-

A dataframe containing the following variables.

name
-

the name of the compound observed. Note that T245 is used as - an acronym for 2,4,5-T. T245 is a legitimate object name - in R, which is necessary for specifying models using - mkinmod.

- -
time
-

a numeric vector containing sampling times in days after - treatment

- -
value
-

a numeric vector containing concentrations in percent of applied radioactivity

- -
soil
-

a factor containing the name of the soil

- - -
-
-

Source

-

McCall P, Vrona SA, Kelley SS (1981) Fate of uniformly carbon-14 ring labelled 2,4,5-Trichlorophenoxyacetic acid and 2,4-dichlorophenoxyacetic acid. J Agric Chem 29, 100-107 - doi:10.1021/jf00103a026

-
- -
-

Examples

- 
  SFO_SFO_SFO <- mkinmod(T245 = list(type = "SFO", to = "phenol"),
-    phenol = list(type = "SFO", to = "anisole"),
-    anisole = list(type = "SFO"))
-#> Temporary DLL for differentials generated and loaded
-  # \dontrun{
-    fit.1 <- mkinfit(SFO_SFO_SFO, subset(mccall81_245T, soil == "Commerce"), quiet = TRUE)
-#> Warning: Observations with value of zero were removed from the data
-    summary(fit.1)$bpar
-#>                         Estimate   se_notrans   t value       Pr(>t)
-#> T245_0              1.038550e+02 2.1847074945 47.537272 4.472189e-18
-#> k_T245              4.337042e-02 0.0018983965 22.845818 2.276911e-13
-#> k_phenol            4.050581e-01 0.2986993563  1.356073 9.756989e-02
-#> k_anisole           6.678742e-03 0.0008021439  8.326114 2.623177e-07
-#> f_T245_to_phenol    6.227599e-01 0.3985340558  1.562627 6.949413e-02
-#> f_phenol_to_anisole 1.000000e+00 0.6718439825  1.488441 7.867789e-02
-#> sigma               2.514628e+00 0.4907558883  5.123989 6.233157e-05
-#>                            Lower        Upper
-#> T245_0              99.246061385 1.084640e+02
-#> k_T245               0.039631621 4.746194e-02
-#> k_phenol             0.218013879 7.525762e-01
-#> k_anisole            0.005370739 8.305299e-03
-#> f_T245_to_phenol     0.547559081 6.924813e-01
-#> f_phenol_to_anisole  0.000000000 1.000000e+00
-#> sigma                1.706607296 3.322649e+00
-    endpoints(fit.1)
-#> $ff
-#>    T245_phenol      T245_sink phenol_anisole    phenol_sink 
-#>   6.227599e-01   3.772401e-01   1.000000e+00   3.773626e-10 
-#> 
-#> $distimes
-#>               DT50      DT90
-#> T245     15.982025  53.09114
-#> phenol    1.711229   5.68458
-#> anisole 103.784093 344.76329
-#> 
-    # formation fraction from phenol to anisol is practically 1. As we cannot
-    # fix formation fractions when using the ilr transformation, we can turn of
-    # the sink in the model generation
-    SFO_SFO_SFO_2 <- mkinmod(T245 = list(type = "SFO", to = "phenol"),
-      phenol = list(type = "SFO", to = "anisole", sink = FALSE),
-      anisole = list(type = "SFO"))
-#> Temporary DLL for differentials generated and loaded
-    fit.2 <- mkinfit(SFO_SFO_SFO_2, subset(mccall81_245T, soil == "Commerce"),
-      quiet = TRUE)
-#> Warning: Observations with value of zero were removed from the data
-    summary(fit.2)$bpar
-#>                      Estimate   se_notrans   t value       Pr(>t)        Lower
-#> T245_0           1.038550e+02 2.1623653066 48.028439 4.993108e-19 99.271020284
-#> k_T245           4.337042e-02 0.0018343666 23.643268 3.573556e-14  0.039650976
-#> k_phenol         4.050582e-01 0.1177237473  3.440752 1.679254e-03  0.218746587
-#> k_anisole        6.678742e-03 0.0006829745  9.778903 1.872894e-08  0.005377083
-#> f_T245_to_phenol 6.227599e-01 0.0342197875 18.198824 2.039411e-12  0.547975637
-#> sigma            2.514628e+00 0.3790944250  6.633250 2.875782e-06  1.710983655
-#>                         Upper
-#> T245_0           108.43904074
-#> k_T245             0.04743877
-#> k_phenol           0.75005585
-#> k_anisole          0.00829550
-#> f_T245_to_phenol   0.69212308
-#> sigma              3.31827222
-    endpoints(fit.1)
-#> $ff
-#>    T245_phenol      T245_sink phenol_anisole    phenol_sink 
-#>   6.227599e-01   3.772401e-01   1.000000e+00   3.773626e-10 
-#> 
-#> $distimes
-#>               DT50      DT90
-#> T245     15.982025  53.09114
-#> phenol    1.711229   5.68458
-#> anisole 103.784093 344.76329
-#> 
-    plot_sep(fit.2)
-
-  # }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mean_degparms.html b/docs/dev/reference/mean_degparms.html deleted file mode 100644 index a374d532..00000000 --- a/docs/dev/reference/mean_degparms.html +++ /dev/null @@ -1,182 +0,0 @@ - -Calculate mean degradation parameters for an mmkin row object — mean_degparms • mkin - - -
-
- - - -
-
-
-

Calculate mean degradation parameters for an mmkin row object

- Source: R/mean_degparms.R - -
- -
-

Calculate mean degradation parameters for an mmkin row object

-
- -
- 
mean_degparms(
-  object,
-  random = FALSE,
-  test_log_parms = FALSE,
-  conf.level = 0.6,
-  default_log_parms = NA
-)
-
- -
-

Arguments

-
object
-

An mmkin row object containing several fits of the same model to different datasets

- - -
random
-

Should a list with fixed and random effects be returned?

- - -
test_log_parms
-

If TRUE, log parameters are only considered in -the mean calculations if their untransformed counterparts (most likely -rate constants) pass the t-test for significant difference from zero.

- - -
conf.level
-

Possibility to adjust the required confidence level -for parameter that are tested if requested by 'test_log_parms'.

- - -
default_log_parms
-

If set to a numeric value, this is used -as a default value for the tested log parameters that failed the -t-test.

- -
-
-

Value

- - -

If random is FALSE (default), a named vector containing mean values -of the fitted degradation model parameters. If random is TRUE, a list with -fixed and random effects, in the format required by the start argument of -nlme for the case of a single grouping variable ds.

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mhmkin-1.png b/docs/dev/reference/mhmkin-1.png deleted file mode 100644 index 1c99aead..00000000 Binary files a/docs/dev/reference/mhmkin-1.png and /dev/null differ diff --git a/docs/dev/reference/mhmkin-2.png b/docs/dev/reference/mhmkin-2.png deleted file mode 100644 index ea04ebfd..00000000 Binary files a/docs/dev/reference/mhmkin-2.png and /dev/null differ diff --git a/docs/dev/reference/mhmkin.html b/docs/dev/reference/mhmkin.html deleted file mode 100644 index b41c11df..00000000 --- a/docs/dev/reference/mhmkin.html +++ /dev/null @@ -1,336 +0,0 @@ - -Fit nonlinear mixed-effects models built from one or more kinetic -degradation models and one or more error models — mhmkin • mkin - - -
-
- - - -
-
-
-

Fit nonlinear mixed-effects models built from one or more kinetic -degradation models and one or more error models

- Source: R/mhmkin.R - -
- -
-

The name of the methods expresses that (multiple) hierarchichal -(also known as multilevel) multicompartment kinetic models are -fitted. Our kinetic models are nonlinear, so we can use various nonlinear -mixed-effects model fitting functions.

-
- -
- 
mhmkin(objects, ...)
-
-# S3 method for mmkin
-mhmkin(objects, ...)
-
-# S3 method for list
-mhmkin(
-  objects,
-  backend = "saemix",
-  algorithm = "saem",
-  no_random_effect = NULL,
-  ...,
-  cores = if (Sys.info()["sysname"] == "Windows") 1 else parallel::detectCores(),
-  cluster = NULL
-)
-
-# S3 method for mhmkin
-[(x, i, j, ..., drop = FALSE)
-
-# S3 method for mhmkin
-print(x, ...)
-
- -
-

Arguments

-
objects
-

A list of mmkin objects containing fits of the same -degradation models to the same data, but using different error models. -Alternatively, a single mmkin object containing fits of several -degradation models to the same data

- - -
...
-

Further arguments that will be passed to the nonlinear mixed-effects -model fitting function.

- - -
backend
-

The backend to be used for fitting. Currently, only saemix is -supported

- - -
algorithm
-

The algorithm to be used for fitting (currently not used)

- - -
no_random_effect
-

Default is NULL and will be passed to saem. If a -character vector is supplied, it will be passed to all calls to saem, -which will exclude random effects for all matching parameters. Alternatively, -a list of character vectors or an object of class illparms.mhmkin can be -specified. They have to have the same dimensions that the return object of -the current call will have, i.e. the number of rows must match the number -of degradation models in the mmkin object(s), and the number of columns must -match the number of error models used in the mmkin object(s).

- - -
cores
-

The number of cores to be used for multicore processing. This -is only used when the cluster argument is NULL. On Windows -machines, cores > 1 is not supported, you need to use the cluster -argument to use multiple logical processors. Per default, all cores detected -by parallel::detectCores() are used, except on Windows where the default -is 1.

- - -
cluster
-

A cluster as returned by makeCluster to be used for -parallel execution.

- - -
x
-

An mhmkin object.

- - -
i
-

Row index selecting the fits for specific models

- - -
j
-

Column index selecting the fits to specific datasets

- - -
drop
-

If FALSE, the method always returns an mhmkin object, otherwise -either a list of fit objects or a single fit object.

- -
-
-

Value

- - -

A two-dimensional array of fit objects and/or try-errors that can -be indexed using the degradation model names for the first index (row index) -and the error model names for the second index (column index), with class -attribute 'mhmkin'.

- - -

An object inheriting from mhmkin.

-
-
-

See also

-

[.mhmkin for subsetting mhmkin objects

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 
# \dontrun{
-# We start with separate evaluations of all the first six datasets with two
-# degradation models and two error models
-f_sep_const <- mmkin(c("SFO", "FOMC"), ds_fomc[1:6], cores = 2, quiet = TRUE)
-f_sep_tc <- update(f_sep_const, error_model = "tc")
-# The mhmkin function sets up hierarchical degradation models aka
-# nonlinear mixed-effects models for all four combinations, specifying
-# uncorrelated random effects for all degradation parameters
-f_saem_1 <- mhmkin(list(f_sep_const, f_sep_tc), cores = 2)
-status(f_saem_1)
-#>            error
-#> degradation const tc
-#>        SFO  OK    OK
-#>        FOMC OK    OK
-#> 
-#> OK: Fit terminated successfully
-# The 'illparms' function shows that in all hierarchical fits, at least
-# one random effect is ill-defined (the confidence interval for the
-# random effect expressed as standard deviation includes zero)
-illparms(f_saem_1)
-#>            error
-#> degradation const        tc                        
-#>        SFO  sd(parent_0) sd(parent_0)              
-#>        FOMC sd(log_beta) sd(parent_0), sd(log_beta)
-# Therefore we repeat the fits, excluding the ill-defined random effects
-f_saem_2 <- update(f_saem_1, no_random_effect = illparms(f_saem_1))
-status(f_saem_2)
-#>            error
-#> degradation const tc
-#>        SFO  OK    OK
-#>        FOMC OK    OK
-#> 
-#> OK: Fit terminated successfully
-illparms(f_saem_2)
-#>            error
-#> degradation const tc
-#>        SFO          
-#>        FOMC         
-# Model comparisons show that FOMC with two-component error is preferable,
-# and confirms our reduction of the default parameter model
-anova(f_saem_1)
-#> Data: 95 observations of 1 variable(s) grouped in 6 datasets
-#> 
-#>            npar    AIC    BIC     Lik
-#> SFO const     5 574.40 573.35 -282.20
-#> SFO tc        6 543.72 542.47 -265.86
-#> FOMC const    7 489.67 488.22 -237.84
-#> FOMC tc       8 406.11 404.44 -195.05
-anova(f_saem_2)
-#> Data: 95 observations of 1 variable(s) grouped in 6 datasets
-#> 
-#>            npar    AIC    BIC     Lik
-#> SFO const     4 572.22 571.39 -282.11
-#> SFO tc        5 541.63 540.59 -265.81
-#> FOMC const    6 487.38 486.13 -237.69
-#> FOMC tc       6 402.12 400.88 -195.06
-# The convergence plot for the selected model looks fine
-saemix::plot(f_saem_2[["FOMC", "tc"]]$so, plot.type = "convergence")
-
-# The plot of predictions versus data shows that we have a pretty data-rich
-# situation with homogeneous distribution of residuals, because we used the
-# same degradation model, error model and parameter distribution model that
-# was used in the data generation.
-plot(f_saem_2[["FOMC", "tc"]])
-
-# We can specify the same parameter model reductions manually
-no_ranef <- list("parent_0", "log_beta", "parent_0", c("parent_0", "log_beta"))
-dim(no_ranef) <- c(2, 2)
-f_saem_2m <- update(f_saem_1, no_random_effect = no_ranef)
-anova(f_saem_2m)
-#> Data: 95 observations of 1 variable(s) grouped in 6 datasets
-#> 
-#>            npar    AIC    BIC     Lik
-#> SFO const     4 572.22 571.39 -282.11
-#> SFO tc        5 541.63 540.59 -265.81
-#> FOMC const    6 487.38 486.13 -237.69
-#> FOMC tc       6 402.12 400.88 -195.06
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mixed-1.png b/docs/dev/reference/mixed-1.png deleted file mode 100644 index b053d9c9..00000000 Binary files a/docs/dev/reference/mixed-1.png and /dev/null differ diff --git a/docs/dev/reference/mixed.html b/docs/dev/reference/mixed.html deleted file mode 100644 index 1709944a..00000000 --- a/docs/dev/reference/mixed.html +++ /dev/null @@ -1,245 +0,0 @@ - -Create a mixed effects model from an mmkin row object — mixed • mkin - - -
-
- - - -
-
-
-

Create a mixed effects model from an mmkin row object

- Source: R/mixed.mmkin.R - -
- -
-

Create a mixed effects model from an mmkin row object

-
- -
- 
mixed(object, ...)
-
-# S3 method for mmkin
-mixed(object, method = c("none"), ...)
-
-# S3 method for mixed.mmkin
-print(x, digits = max(3, getOption("digits") - 3), ...)
-
- -
-

Arguments

-
object
-

An mmkin row object

- - -
...
-

Currently not used

- - -
method
-

The method to be used

- - -
x
-

A mixed.mmkin object to print

- - -
digits
-

Number of digits to use for printing.

- -
-
-

Value

- - -

An object of class 'mixed.mmkin' which has the observed data in a -single dataframe which is convenient for plotting

-
- -
-

Examples

- 
sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-n_biphasic <- 8
-err_1 = list(const = 1, prop = 0.07)
-
-DFOP_SFO <- mkinmod(
-  parent = mkinsub("DFOP", "m1"),
-  m1 = mkinsub("SFO"),
-  quiet = TRUE)
-
-set.seed(123456)
-log_sd <- 0.3
-syn_biphasic_parms <- as.matrix(data.frame(
-  k1 = rlnorm(n_biphasic, log(0.05), log_sd),
-  k2 = rlnorm(n_biphasic, log(0.01), log_sd),
-  g = plogis(rnorm(n_biphasic, 0, log_sd)),
-  f_parent_to_m1 = plogis(rnorm(n_biphasic, 0, log_sd)),
-  k_m1 = rlnorm(n_biphasic, log(0.002), log_sd)))
-
-ds_biphasic_mean <- lapply(1:n_biphasic,
-  function(i) {
-    mkinpredict(DFOP_SFO, syn_biphasic_parms[i, ],
-      c(parent = 100, m1 = 0), sampling_times)
-  }
-)
-
-set.seed(123456L)
-ds_biphasic <- lapply(ds_biphasic_mean, function(ds) {
-  add_err(ds,
-    sdfunc = function(value) sqrt(err_1$const^2 + value^2 * err_1$prop^2),
-    n = 1, secondary = "m1")[[1]]
-})
-
-# \dontrun{
-f_mmkin <- mmkin(list("DFOP-SFO" = DFOP_SFO), ds_biphasic, error_model = "tc", quiet = TRUE)
-
-f_mixed <- mixed(f_mmkin)
-print(f_mixed)
-#> Kinetic model fitted by nonlinear regression to each dataset
-#> Structural model:
-#> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
-#>            time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
-#>            * parent
-#> d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)
-#>            * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *
-#>            exp(-k2 * time))) * parent - k_m1 * m1
-#> 
-#> Data:
-#> 271 observations of 2 variable(s) grouped in 8 datasets
-#> 
-#> <mmkin> object
-#> Status of individual fits:
-#> 
-#>           dataset
-#> model      1  2  3  4  5  6  7  8 
-#>   DFOP-SFO OK OK OK OK OK OK OK OK
-#> 
-#> OK: No warnings
-#> 
-#> Mean fitted parameters:
-#>        parent_0        log_k_m1 f_parent_qlogis          log_k1          log_k2 
-#>      100.674757       -8.761916       -0.004347       -3.348812       -3.986853 
-#>        g_qlogis 
-#>       -0.087392 
-plot(f_mixed)
-
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkin_long_to_wide.html b/docs/dev/reference/mkin_long_to_wide.html deleted file mode 100644 index 990506b5..00000000 --- a/docs/dev/reference/mkin_long_to_wide.html +++ /dev/null @@ -1,201 +0,0 @@ - -Convert a dataframe from long to wide format — mkin_long_to_wide • mkin - - -
-
- - - -
-
-
-

Convert a dataframe from long to wide format

- Source: R/mkin_long_to_wide.R - -
- -
-

This function takes a dataframe in the long form, i.e. with a row for each -observed value, and converts it into a dataframe with one independent -variable and several dependent variables as columns.

-
- -
- 
mkin_long_to_wide(long_data, time = "time", outtime = "time")
-
- -
-

Arguments

-
long_data
-

The dataframe must contain one variable called "time" with -the time values specified by the time argument, one column called -"name" with the grouping of the observed values, and finally one column of -observed values called "value".

- - -
time
-

The name of the time variable in the long input data.

- - -
outtime
-

The name of the time variable in the wide output data.

- -
-
-

Value

- - -

Dataframe in wide format.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-mkin_long_to_wide(FOCUS_2006_D)
-#>    time parent    m1
-#> 1     0  99.46  0.00
-#> 2     0 102.04  0.00
-#> 3     1  93.50  4.84
-#> 4     1  92.50  5.64
-#> 5     3  63.23 12.91
-#> 6     3  68.99 12.96
-#> 7     7  52.32 22.97
-#> 8     7  55.13 24.47
-#> 9    14  27.27 41.69
-#> 10   14  26.64 33.21
-#> 11   21  11.50 44.37
-#> 12   21  11.64 46.44
-#> 13   35   2.85 41.22
-#> 14   35   2.91 37.95
-#> 15   50   0.69 41.19
-#> 16   50   0.63 40.01
-#> 17   75   0.05 40.09
-#> 18   75   0.06 33.85
-#> 19  100     NA 31.04
-#> 20  100     NA 33.13
-#> 21  120     NA 25.15
-#> 22  120     NA 33.31
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkin_wide_to_long.html b/docs/dev/reference/mkin_wide_to_long.html deleted file mode 100644 index a324d3b8..00000000 --- a/docs/dev/reference/mkin_wide_to_long.html +++ /dev/null @@ -1,181 +0,0 @@ - -Convert a dataframe with observations over time into long format — mkin_wide_to_long • mkin - - -
-
- - - -
-
-
-

Convert a dataframe with observations over time into long format

- Source: R/mkin_wide_to_long.R - -
- -
-

This function simply takes a dataframe with one independent variable and -several dependent variable and converts it into the long form as required by -mkinfit.

-
- -
- 
mkin_wide_to_long(wide_data, time = "t")
-
- -
-

Arguments

-
wide_data
-

The dataframe must contain one variable with the time -values specified by the time argument and usually more than one -column of observed values.

- - -
time
-

The name of the time variable.

- -
-
-

Value

- - -

Dataframe in long format as needed for mkinfit.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-wide <- data.frame(t = c(1,2,3), x = c(1,4,7), y = c(3,4,5))
-mkin_wide_to_long(wide)
-#>   name time value
-#> 1    x    1     1
-#> 2    x    2     4
-#> 3    x    3     7
-#> 4    y    1     3
-#> 5    y    2     4
-#> 6    y    3     5
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkinds.html b/docs/dev/reference/mkinds.html deleted file mode 100644 index 6219766e..00000000 --- a/docs/dev/reference/mkinds.html +++ /dev/null @@ -1,262 +0,0 @@ - -A dataset class for mkin — mkinds • mkin - - -
-
- - - -
-
-
-

A dataset class for mkin

- Source: R/mkinds.R - -
- -
-

At the moment this dataset class is hardly used in mkin. For example, -mkinfit does not take mkinds datasets as argument, but works with dataframes -such as the on contained in the data field of mkinds objects. Some datasets -provided by this package come as mkinds objects nevertheless.

-
- -
- 
# S3 method for mkinds
-print(x, data = FALSE, ...)
-
- -
-

Arguments

-
x
-

An mkinds object.

- - -
data
-

Should the data be printed?

- - -
...
-

Not used.

- -
-
-

Public fields

-

title
-

A full title for the dataset

- - -
sampling_times
-

The sampling times

- - -
time_unit
-

The time unit

- - -
observed
-

Names of the observed variables

- - -
unit
-

The unit of the observations

- - -
replicates
-

The maximum number of replicates per sampling time

- - -
data
-

A data frame with at least the columns name, time -and value in order to be compatible with mkinfit

- - -

-
-
-

Methods

- -
-

Public methods

- -

-

Method new()

-

Create a new mkinds object

-

Usage

-

mkinds$new(title = "", data, time_unit = NA, unit = NA)

-
- -
-

Arguments

-

title
-

The dataset title

- - -
data
-

The data

- - -
time_unit
-

The time unit

- - -
unit
-

The unit of the observations

- - -

-
- -

-

Method clone()

-

The objects of this class are cloneable with this method.

-

Usage

-

mkinds$clone(deep = FALSE)

-
- -
-

Arguments

-

deep
-

Whether to make a deep clone.

- - -

-
- -
- -
- -
-

Examples

- 

-mds <- mkinds$new("FOCUS A", FOCUS_2006_A)
-print(mds)
-#> <mkinds> with $title:  FOCUS A 
-#> Observed compounds $observed:  parent 
-#> Sampling times $sampling_times:
-#> 0, 3, 7, 14, 30, 62, 90, 118 
-#> With a maximum of  1  replicates
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkindsg.html b/docs/dev/reference/mkindsg.html deleted file mode 100644 index 6e221a23..00000000 --- a/docs/dev/reference/mkindsg.html +++ /dev/null @@ -1,450 +0,0 @@ - -A class for dataset groups for mkin — mkindsg • mkin - - -
-
- - - -
-
-
-

A class for dataset groups for mkin

- Source: R/mkinds.R - -
- -
-

A container for working with datasets that share at least one compound, -so that combined evaluations are desirable.

-

Time normalisation factors are initialised with a value of 1 for each -dataset if no data are supplied.

-
- -
- 
# S3 method for mkindsg
-print(x, data = FALSE, verbose = data, ...)
-
- -
-

Arguments

-
x
-

An mkindsg object.

- - -
data
-

Should the mkinds objects be printed with their data?

- - -
verbose
-

Should the mkinds objects be printed?

- - -
...
-

Not used.

- -
-
-

Public fields

-

title
-

A title for the dataset group

- - -
ds
-

A list of mkinds objects

- - -
observed_n
-

Occurrence counts of compounds in datasets

- - -
f_time_norm
-

Time normalisation factors

- - -
meta
-

A data frame with a row for each dataset, -containing additional information in the form -of categorical data (factors) or numerical data -(e.g. temperature, moisture, -or covariates like soil pH).

- - -

-
-
-

Methods

- -
-

Public methods

- -

-

Method new()

-

Create a new mkindsg object

-

Usage

-

mkindsg$new(title = "", ds, f_time_norm = rep(1, length(ds)), meta)

-
- -
-

Arguments

-

title
-

The title

- - -
ds
-

A list of mkinds objects

- - -
f_time_norm
-

Time normalisation factors

- - -
meta
-

The meta data

- - -

-
- -

-

Method clone()

-

The objects of this class are cloneable with this method.

-

Usage

-

mkindsg$clone(deep = FALSE)

-
- -
-

Arguments

-

deep
-

Whether to make a deep clone.

- - -

-
- -
- -
- -
-

Examples

- 

-mdsg <- mkindsg$new("Experimental X", experimental_data_for_UBA_2019[6:10])
-print(mdsg)
-#> <mkindsg> holding 5 mkinds objects
-#> Title $title:  Experimental X 
-#> Occurrence of observed compounds $observed_n:
-#> parent     A1 
-#>      5      5 
-print(mdsg, verbose = TRUE)
-#> <mkindsg> holding 5 mkinds objects
-#> Title $title:  Experimental X 
-#> Occurrence of observed compounds $observed_n:
-#> parent     A1 
-#>      5      5 
-#> 
-#> Datasets $ds:
-#> <mkinds> with $title:  Soil 6 
-#> Observed compounds $observed:  parent, A1 
-#> Sampling times $sampling_times:
-#> 0, 3, 6, 10, 20, 34, 55, 90, 112, 132 
-#> With a maximum of  2  replicates
-#> Time unit:  days 
-#> Observation unit:  \%AR 
-#> 
-#> <mkinds> with $title:  Soil 7 
-#> Observed compounds $observed:  parent, A1 
-#> Sampling times $sampling_times:
-#> 0, 3, 7, 14, 30, 60, 90, 120, 180 
-#> With a maximum of  2  replicates
-#> Time unit:  days 
-#> Observation unit:  \%AR 
-#> 
-#> <mkinds> with $title:  Soil 8 
-#> Observed compounds $observed:  parent, A1 
-#> Sampling times $sampling_times:
-#> 0, 1, 3, 8, 14, 27, 48, 70 
-#> With a maximum of  2  replicates
-#> Time unit:  days 
-#> Observation unit:  \%AR 
-#> 
-#> <mkinds> with $title:  Soil 9 
-#> Observed compounds $observed:  parent, A1 
-#> Sampling times $sampling_times:
-#> 0, 1, 3, 8, 14, 27, 48, 70, 91, 120 
-#> With a maximum of  2  replicates
-#> Time unit:  days 
-#> Observation unit:  \%AR 
-#> 
-#> <mkinds> with $title:  Soil 10 
-#> Observed compounds $observed:  parent, A1 
-#> Sampling times $sampling_times:
-#> 0, 8, 14, 21, 41, 63, 91, 120 
-#> With a maximum of  2  replicates
-#> Time unit:  days 
-#> Observation unit:  \%AR 
-print(mdsg, verbose = TRUE, data = TRUE)
-#> <mkindsg> holding 5 mkinds objects
-#> Title $title:  Experimental X 
-#> Occurrence of observed compounds $observed_n:
-#> parent     A1 
-#>      5      5 
-#> 
-#> Datasets $ds:
-#> <mkinds> with $title:  Soil 6 
-#> Observed compounds $observed:  parent, A1 
-#> Sampling times $sampling_times:
-#> 0, 3, 6, 10, 20, 34, 55, 90, 112, 132 
-#> With a maximum of  2  replicates
-#> Time unit:  days 
-#> Observation unit:  \%AR 
-#>    time parent   A1
-#> 1     0   97.2   NA
-#> 2     0   96.4   NA
-#> 3     3   71.1  4.3
-#> 4     3   69.2  4.6
-#> 5     6   58.1  7.0
-#> 6     6   56.6  7.2
-#> 7    10   44.4  8.2
-#> 8    10   43.4  8.0
-#> 9    20   33.3 11.0
-#> 10   20   29.2 13.7
-#> 11   34   17.6 11.5
-#> 12   34   18.0 12.7
-#> 13   55   10.5 14.9
-#> 14   55    9.3 14.5
-#> 15   90    4.5 12.1
-#> 16   90    4.7 12.3
-#> 17  112    3.0  9.9
-#> 18  112    3.4 10.2
-#> 19  132    2.3  8.8
-#> 20  132    2.7  7.8
-#> 
-#> <mkinds> with $title:  Soil 7 
-#> Observed compounds $observed:  parent, A1 
-#> Sampling times $sampling_times:
-#> 0, 3, 7, 14, 30, 60, 90, 120, 180 
-#> With a maximum of  2  replicates
-#> Time unit:  days 
-#> Observation unit:  \%AR 
-#>    time parent   A1
-#> 1     0   93.6   NA
-#> 2     0   92.3   NA
-#> 3     3   87.0  3.9
-#> 4     3   82.2  3.1
-#> 5     7   74.0  6.9
-#> 6     7   73.9  6.6
-#> 7    14   64.2 10.4
-#> 8    14   69.5  8.3
-#> 9    30   54.0 14.4
-#> 10   30   54.6 13.7
-#> 11   60   41.1 22.1
-#> 12   60   38.4 22.3
-#> 13   90   32.5 27.5
-#> 14   90   35.5 25.4
-#> 15  120   28.1 28.0
-#> 16  120   29.0 26.6
-#> 17  180   26.5 25.8
-#> 18  180   27.6 25.3
-#> 
-#> <mkinds> with $title:  Soil 8 
-#> Observed compounds $observed:  parent, A1 
-#> Sampling times $sampling_times:
-#> 0, 1, 3, 8, 14, 27, 48, 70 
-#> With a maximum of  2  replicates
-#> Time unit:  days 
-#> Observation unit:  \%AR 
-#>    time parent   A1
-#> 1     0   91.9   NA
-#> 2     0   90.8   NA
-#> 3     1   64.9  9.6
-#> 4     1   66.2  7.7
-#> 5     3   43.5 15.0
-#> 6     3   44.1 15.1
-#> 7     8   18.3 21.2
-#> 8     8   18.1 21.1
-#> 9    14   10.2 19.7
-#> 10   14   10.8 18.9
-#> 11   27    4.9 17.5
-#> 12   27    3.3 15.9
-#> 13   48    1.6  9.5
-#> 14   48    1.5  9.8
-#> 15   70    1.1  6.2
-#> 16   70    0.9  6.1
-#> 
-#> <mkinds> with $title:  Soil 9 
-#> Observed compounds $observed:  parent, A1 
-#> Sampling times $sampling_times:
-#> 0, 1, 3, 8, 14, 27, 48, 70, 91, 120 
-#> With a maximum of  2  replicates
-#> Time unit:  days 
-#> Observation unit:  \%AR 
-#>    time parent   A1
-#> 1     0   99.8   NA
-#> 2     0   98.3   NA
-#> 3     1   77.1  4.2
-#> 4     1   77.2  3.9
-#> 5     3   59.0  7.4
-#> 6     3   58.1  7.9
-#> 7     8   27.4 14.5
-#> 8     8   29.2 13.7
-#> 9    14   19.1 14.2
-#> 10   14   29.6 12.2
-#> 11   27   10.1 13.7
-#> 12   27   18.2 13.2
-#> 13   48    4.5 13.6
-#> 14   48    9.1 15.4
-#> 15   70    2.3 10.4
-#> 16   70    2.9 11.6
-#> 17   91    2.0 10.0
-#> 18   91    1.8  9.5
-#> 19  120    2.0  9.1
-#> 20  120    2.2  9.0
-#> 
-#> <mkinds> with $title:  Soil 10 
-#> Observed compounds $observed:  parent, A1 
-#> Sampling times $sampling_times:
-#> 0, 8, 14, 21, 41, 63, 91, 120 
-#> With a maximum of  2  replicates
-#> Time unit:  days 
-#> Observation unit:  \%AR 
-#>    time parent   A1
-#> 1     0   96.1   NA
-#> 2     0   94.3   NA
-#> 3     8   73.9  3.3
-#> 4     8   73.9  3.4
-#> 5    14   69.4  3.9
-#> 6    14   73.1  2.9
-#> 7    21   65.6  6.4
-#> 8    21   65.3  7.2
-#> 9    41   55.9  9.1
-#> 10   41   54.4  8.5
-#> 11   63   47.0 11.7
-#> 12   63   49.3 12.0
-#> 13   91   44.7 13.3
-#> 14   91   46.7 13.2
-#> 15  120   42.1 14.3
-#> 16  120   41.3 12.1
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkinerrmin.html b/docs/dev/reference/mkinerrmin.html deleted file mode 100644 index 3a8b9610..00000000 --- a/docs/dev/reference/mkinerrmin.html +++ /dev/null @@ -1,210 +0,0 @@ - -Calculate the minimum error to assume in order to pass the variance test — mkinerrmin • mkin - - -
-
- - - -
-
-
-

Calculate the minimum error to assume in order to pass the variance test

- Source: R/mkinerrmin.R - -
- -
-

This function finds the smallest relative error still resulting in passing -the chi-squared test as defined in the FOCUS kinetics report from 2006.

-
- -
- 
mkinerrmin(fit, alpha = 0.05)
-
- -
-

Arguments

-
fit
-

an object of class mkinfit.

- - -
alpha
-

The confidence level chosen for the chi-squared test.

- -
-
-

Value

- - -

A dataframe with the following components:

-
err.min
-

The -relative error, expressed as a fraction.

-
n.optim
-

The number of -optimised parameters attributed to the data series.

-
df
-

The number of -remaining degrees of freedom for the chi2 error level calculations. Note -that mean values are used for the chi2 statistic and therefore every time -point with observed values in the series only counts one time.

-

The -dataframe has one row for the total dataset and one further row for each -observed state variable in the model.

-
-
-

Details

-

This function is used internally by summary.mkinfit.

-
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU -Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC -Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
- -
-

Examples

- 

-SFO_SFO = mkinmod(parent = mkinsub("SFO", to = "m1"),
-                  m1 = mkinsub("SFO"),
-                  use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-fit_FOCUS_D = mkinfit(SFO_SFO, FOCUS_2006_D, quiet = TRUE)
-#> Warning: Observations with value of zero were removed from the data
-round(mkinerrmin(fit_FOCUS_D), 4)
-#>          err.min n.optim df
-#> All data  0.0640       4 15
-#> parent    0.0646       2  7
-#> m1        0.0469       2  8
-# \dontrun{
-  fit_FOCUS_E = mkinfit(SFO_SFO, FOCUS_2006_E, quiet = TRUE)
-  round(mkinerrmin(fit_FOCUS_E), 4)
-#>          err.min n.optim df
-#> All data  0.1544       4 13
-#> parent    0.1659       2  7
-#> m1        0.1095       2  6
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkinerrplot-1.png b/docs/dev/reference/mkinerrplot-1.png deleted file mode 100644 index 078614fc..00000000 Binary files a/docs/dev/reference/mkinerrplot-1.png and /dev/null differ diff --git a/docs/dev/reference/mkinerrplot.html b/docs/dev/reference/mkinerrplot.html deleted file mode 100644 index bc9b828a..00000000 --- a/docs/dev/reference/mkinerrplot.html +++ /dev/null @@ -1,245 +0,0 @@ - -Function to plot squared residuals and the error model for an mkin object — mkinerrplot • mkin - - -
-
- - - -
-
-
-

Function to plot squared residuals and the error model for an mkin object

- Source: R/mkinerrplot.R - -
- -
-

This function plots the squared residuals for the specified subset of the -observed variables from an mkinfit object. In addition, one or more dashed -line(s) show the fitted error model. A combined plot of the fitted model -and this error model plot can be obtained with plot.mkinfit -using the argument show_errplot = TRUE.

-
- -
- 
mkinerrplot(
-  object,
-  obs_vars = names(object$mkinmod$map),
-  xlim = c(0, 1.1 * max(object$data$predicted)),
-  xlab = "Predicted",
-  ylab = "Squared residual",
-  maxy = "auto",
-  legend = TRUE,
-  lpos = "topright",
-  col_obs = "auto",
-  pch_obs = "auto",
-  frame = TRUE,
-  ...
-)
-
- -
-

Arguments

-
object
-

A fit represented in an mkinfit object.

- - -
obs_vars
-

A character vector of names of the observed variables for -which residuals should be plotted. Defaults to all observed variables in -the model

- - -
xlim
-

plot range in x direction.

- - -
xlab
-

Label for the x axis.

- - -
ylab
-

Label for the y axis.

- - -
maxy
-

Maximum value of the residuals. This is used for the scaling of -the y axis and defaults to "auto".

- - -
legend
-

Should a legend be plotted?

- - -
lpos
-

Where should the legend be placed? Default is "topright". Will -be passed on to legend.

- - -
col_obs
-

Colors for the observed variables.

- - -
pch_obs
-

Symbols to be used for the observed variables.

- - -
frame
-

Should a frame be drawn around the plots?

- - -
...
-

further arguments passed to plot.

- -
-
-

Value

- - -

Nothing is returned by this function, as it is called for its side -effect, namely to produce a plot.

-
-
-

See also

-

mkinplot, for a way to plot the data and the fitted -lines of the mkinfit object.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-# \dontrun{
-model <- mkinmod(parent = mkinsub("SFO", "m1"), m1 = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-fit <- mkinfit(model, FOCUS_2006_D, error_model = "tc", quiet = TRUE)
-#> Warning: Observations with value of zero were removed from the data
-mkinerrplot(fit)
-
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkinfit-1.png b/docs/dev/reference/mkinfit-1.png deleted file mode 100644 index 578f64a5..00000000 Binary files a/docs/dev/reference/mkinfit-1.png and /dev/null differ diff --git a/docs/dev/reference/mkinfit.html b/docs/dev/reference/mkinfit.html deleted file mode 100644 index 237d903e..00000000 --- a/docs/dev/reference/mkinfit.html +++ /dev/null @@ -1,719 +0,0 @@ - -Fit a kinetic model to data with one or more state variables — mkinfit • mkin - - -
-
- - - -
-
-
-

Fit a kinetic model to data with one or more state variables

- Source: R/mkinfit.R - -
- -
-

This function maximises the likelihood of the observed data using the Port -algorithm stats::nlminb(), and the specified initial or fixed -parameters and starting values. In each step of the optimisation, the -kinetic model is solved using the function mkinpredict(), except -if an analytical solution is implemented, in which case the model is solved -using the degradation function in the mkinmod object. The -parameters of the selected error model are fitted simultaneously with the -degradation model parameters, as both of them are arguments of the -likelihood function.

-
- -
- 
mkinfit(
-  mkinmod,
-  observed,
-  parms.ini = "auto",
-  state.ini = "auto",
-  err.ini = "auto",
-  fixed_parms = NULL,
-  fixed_initials = names(mkinmod$diffs)[-1],
-  from_max_mean = FALSE,
-  solution_type = c("auto", "analytical", "eigen", "deSolve"),
-  method.ode = "lsoda",
-  use_compiled = "auto",
-  control = list(eval.max = 300, iter.max = 200),
-  transform_rates = TRUE,
-  transform_fractions = TRUE,
-  quiet = FALSE,
-  atol = 1e-08,
-  rtol = 1e-10,
-  error_model = c("const", "obs", "tc"),
-  error_model_algorithm = c("auto", "d_3", "direct", "twostep", "threestep", "fourstep",
-    "IRLS", "OLS"),
-  reweight.tol = 1e-08,
-  reweight.max.iter = 10,
-  trace_parms = FALSE,
-  test_residuals = FALSE,
-  ...
-)
-
- -
-

Arguments

-
mkinmod
-

A list of class mkinmod, containing the kinetic -model to be fitted to the data, or one of the shorthand names ("SFO", -"FOMC", "DFOP", "HS", "SFORB", "IORE"). If a shorthand name is given, a -parent only degradation model is generated for the variable with the -highest value in observed.

- - -
observed
-

A dataframe with the observed data. The first column called -"name" must contain the name of the observed variable for each data point. -The second column must contain the times of observation, named "time". -The third column must be named "value" and contain the observed values. -Zero values in the "value" column will be removed, with a warning, in -order to avoid problems with fitting the two-component error model. This -is not expected to be a problem, because in general, values of zero are -not observed in degradation data, because there is a lower limit of -detection.

- - -
parms.ini
-

A named vector of initial values for the parameters, -including parameters to be optimised and potentially also fixed parameters -as indicated by fixed_parms. If set to "auto", initial values for -rate constants are set to default values. Using parameter names that are -not in the model gives an error.

-

It is possible to only specify a subset of the parameters that the model -needs. You can use the parameter lists "bparms.ode" from a previously -fitted model, which contains the differential equation parameters from -this model. This works nicely if the models are nested. An example is -given below.

- - -
state.ini
-

A named vector of initial values for the state variables of -the model. In case the observed variables are represented by more than one -model variable, the names will differ from the names of the observed -variables (see map component of mkinmod). The default -is to set the initial value of the first model variable to the mean of the -time zero values for the variable with the maximum observed value, and all -others to 0. If this variable has no time zero observations, its initial -value is set to 100.

- - -
err.ini
-

A named vector of initial values for the error model -parameters to be optimised. If set to "auto", initial values are set to -default values. Otherwise, inital values for all error model parameters -must be given.

- - -
fixed_parms
-

The names of parameters that should not be optimised but -rather kept at the values specified in parms.ini. Alternatively, -a named numeric vector of parameters to be fixed, regardless of the values -in parms.ini.

- - -
fixed_initials
-

The names of model variables for which the initial -state at time 0 should be excluded from the optimisation. Defaults to all -state variables except for the first one.

- - -
from_max_mean
-

If this is set to TRUE, and the model has only one -observed variable, then data before the time of the maximum observed value -(after averaging for each sampling time) are discarded, and this time is -subtracted from all remaining time values, so the time of the maximum -observed mean value is the new time zero.

- - -
solution_type
-

If set to "eigen", the solution of the system of -differential equations is based on the spectral decomposition of the -coefficient matrix in cases that this is possible. If set to "deSolve", a -numerical ode solver from package deSolve is used. If -set to "analytical", an analytical solution of the model is used. This is -only implemented for relatively simple degradation models. The default is -"auto", which uses "analytical" if possible, otherwise "deSolve" if a -compiler is present, and "eigen" if no compiler is present and the model -can be expressed using eigenvalues and eigenvectors.

- - -
method.ode
-

The solution method passed via mkinpredict() -to deSolve::ode() in case the solution type is "deSolve". The default -"lsoda" is performant, but sometimes fails to converge.

- - -
use_compiled
-

If set to FALSE, no compiled version of the -mkinmod model is used in the calls to mkinpredict() even if a compiled -version is present.

- - -
control
-

A list of control arguments passed to stats::nlminb().

- - -
transform_rates
-

Boolean specifying if kinetic rate constants should -be transformed in the model specification used in the fitting for better -compliance with the assumption of normal distribution of the estimator. If -TRUE, also alpha and beta parameters of the FOMC model are -log-transformed, as well as k1 and k2 rate constants for the DFOP and HS -models and the break point tb of the HS model. If FALSE, zero is used as -a lower bound for the rates in the optimisation.

- - -
transform_fractions
-

Boolean specifying if formation fractions -should be transformed in the model specification used in the fitting for -better compliance with the assumption of normal distribution of the -estimator. The default (TRUE) is to do transformations. If TRUE, -the g parameter of the DFOP model is also transformed. Transformations -are described in transform_odeparms.

- - -
quiet
-

Suppress printing out the current value of the negative -log-likelihood after each improvement?

- - -
atol
-

Absolute error tolerance, passed to deSolve::ode(). Default -is 1e-8, which is lower than the default in the deSolve::lsoda() -function which is used per default.

- - -
rtol
-

Absolute error tolerance, passed to deSolve::ode(). Default -is 1e-10, much lower than in deSolve::lsoda().

- - -
error_model
-

If the error model is "const", a constant standard -deviation is assumed.

-

If the error model is "obs", each observed variable is assumed to have its -own variance.

-

If the error model is "tc" (two-component error model), a two component -error model similar to the one described by Rocke and Lorenzato (1995) is -used for setting up the likelihood function. Note that this model -deviates from the model by Rocke and Lorenzato, as their model implies -that the errors follow a lognormal distribution for large values, not a -normal distribution as assumed by this method.

- - -
error_model_algorithm
-

If "auto", the selected algorithm depends on -the error model. If the error model is "const", unweighted nonlinear -least squares fitting ("OLS") is selected. If the error model is "obs", or -"tc", the "d_3" algorithm is selected.

-

The algorithm "d_3" will directly minimize the negative log-likelihood -and independently also use the three step algorithm described below. -The fit with the higher likelihood is returned.

-

The algorithm "direct" will directly minimize the negative log-likelihood.

-

The algorithm "twostep" will minimize the negative log-likelihood after an -initial unweighted least squares optimisation step.

-

The algorithm "threestep" starts with unweighted least squares, then -optimizes only the error model using the degradation model parameters -found, and then minimizes the negative log-likelihood with free -degradation and error model parameters.

-

The algorithm "fourstep" starts with unweighted least squares, then -optimizes only the error model using the degradation model parameters -found, then optimizes the degradation model again with fixed error model -parameters, and finally minimizes the negative log-likelihood with free -degradation and error model parameters.

-

The algorithm "IRLS" (Iteratively Reweighted Least Squares) starts with -unweighted least squares, and then iterates optimization of the error -model parameters and subsequent optimization of the degradation model -using those error model parameters, until the error model parameters -converge.

- - -
reweight.tol
-

Tolerance for the convergence criterion calculated from -the error model parameters in IRLS fits.

- - -
reweight.max.iter
-

Maximum number of iterations in IRLS fits.

- - -
trace_parms
-

Should a trace of the parameter values be listed?

- - -
test_residuals
-

Should the residuals be tested for normal distribution?

- - -
...
-

Further arguments that will be passed on to -deSolve::ode().

- -
-
-

Value

- - -

A list with "mkinfit" in the class attribute.

-
-
-

Details

-

Per default, parameters in the kinetic models are internally transformed in -order to better satisfy the assumption of a normal distribution of their -estimators.

-
-
-

Note

-

When using the "IORE" submodel for metabolites, fitting with -"transform_rates = TRUE" (the default) often leads to failures of the -numerical ODE solver. In this situation it may help to switch off the -internal rate transformation.

-
-
-

References

-

Rocke DM and Lorenzato S (1995) A two-component model -for measurement error in analytical chemistry. Technometrics 37(2), 176-184.

-

Ranke J and Meinecke S (2019) Error Models for the Kinetic Evaluation of Chemical -Degradation Data. Environments 6(12) 124 -doi:10.3390/environments6120124 -.

-
-
-

See also

-

summary.mkinfit, plot.mkinfit, parms and lrtest.

-

Comparisons of models fitted to the same data can be made using -AIC by virtue of the method logLik.mkinfit.

-

Fitting of several models to several datasets in a single call to -mmkin.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-# Use shorthand notation for parent only degradation
-fit <- mkinfit("FOMC", FOCUS_2006_C, quiet = TRUE)
-summary(fit)
-#> mkin version used for fitting:    1.2.3 
-#> R version used for fitting:       4.2.3 
-#> Date of fit:     Sun Apr 16 08:30:40 2023 
-#> Date of summary: Sun Apr 16 08:30:40 2023 
-#> 
-#> Equations:
-#> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent
-#> 
-#> Model predictions using solution type analytical 
-#> 
-#> Fitted using 222 model solutions performed in 0.014 s
-#> 
-#> Error model: Constant variance 
-#> 
-#> Error model algorithm: OLS 
-#> 
-#> Starting values for parameters to be optimised:
-#>          value   type
-#> parent_0  85.1  state
-#> alpha      1.0 deparm
-#> beta      10.0 deparm
-#> 
-#> Starting values for the transformed parameters actually optimised:
-#>               value lower upper
-#> parent_0  85.100000  -Inf   Inf
-#> log_alpha  0.000000  -Inf   Inf
-#> log_beta   2.302585  -Inf   Inf
-#> 
-#> Fixed parameter values:
-#> None
-#> 
-#> Results:
-#> 
-#>        AIC      BIC    logLik
-#>   44.68652 45.47542 -18.34326
-#> 
-#> Optimised, transformed parameters with symmetric confidence intervals:
-#>           Estimate Std. Error    Lower   Upper
-#> parent_0  85.87000     1.8070 81.23000 90.5200
-#> log_alpha  0.05192     0.1353 -0.29580  0.3996
-#> log_beta   0.65100     0.2287  0.06315  1.2390
-#> sigma      1.85700     0.4378  0.73200  2.9830
-#> 
-#> Parameter correlation:
-#>             parent_0  log_alpha   log_beta     sigma
-#> parent_0   1.000e+00 -1.565e-01 -3.142e-01 4.772e-08
-#> log_alpha -1.565e-01  1.000e+00  9.564e-01 1.005e-07
-#> log_beta  -3.142e-01  9.564e-01  1.000e+00 8.541e-08
-#> sigma      4.772e-08  1.005e-07  8.541e-08 1.000e+00
-#> 
-#> Backtransformed parameters:
-#> Confidence intervals for internally transformed parameters are asymmetric.
-#> t-test (unrealistically) based on the assumption of normal distribution
-#> for estimators of untransformed parameters.
-#>          Estimate t value    Pr(>t)   Lower  Upper
-#> parent_0   85.870  47.530 3.893e-08 81.2300 90.520
-#> alpha       1.053   7.393 3.562e-04  0.7439  1.491
-#> beta        1.917   4.373 3.601e-03  1.0650  3.451
-#> sigma       1.857   4.243 4.074e-03  0.7320  2.983
-#> 
-#> FOCUS Chi2 error levels in percent:
-#>          err.min n.optim df
-#> All data   6.657       3  6
-#> parent     6.657       3  6
-#> 
-#> Estimated disappearance times:
-#>         DT50  DT90 DT50back
-#> parent 1.785 15.15     4.56
-#> 
-#> Data:
-#>  time variable observed predicted residual
-#>     0   parent     85.1    85.875  -0.7749
-#>     1   parent     57.9    55.191   2.7091
-#>     3   parent     29.9    31.845  -1.9452
-#>     7   parent     14.6    17.012  -2.4124
-#>    14   parent      9.7     9.241   0.4590
-#>    28   parent      6.6     4.754   1.8460
-#>    63   parent      4.0     2.102   1.8977
-#>    91   parent      3.9     1.441   2.4590
-#>   119   parent      0.6     1.092  -0.4919
-
-# One parent compound, one metabolite, both single first order.
-# We remove zero values from FOCUS dataset D in order to avoid warnings
-FOCUS_D <- subset(FOCUS_2006_D, value != 0)
-# Use mkinsub for convenience in model formulation. Pathway to sink included per default.
-SFO_SFO <- mkinmod(
-  parent = mkinsub("SFO", "m1"),
-  m1 = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-
-# Fit the model quietly to the FOCUS example dataset D using defaults
-fit <- mkinfit(SFO_SFO, FOCUS_D, quiet = TRUE)
-plot_sep(fit)
-
-# As lower parent values appear to have lower variance, we try an alternative error model
-fit.tc <- mkinfit(SFO_SFO, FOCUS_D, quiet = TRUE, error_model = "tc")
-# This avoids the warning, and the likelihood ratio test confirms it is preferable
-lrtest(fit.tc, fit)
-#> Likelihood ratio test
-#> 
-#> Model 1: SFO_SFO with error model tc and fixed parameter(s) m1_0
-#> Model 2: SFO_SFO with error model const and fixed parameter(s) m1_0
-#>   #Df  LogLik Df  Chisq Pr(>Chisq)    
-#> 1   6 -64.983                         
-#> 2   5 -97.224 -1 64.483  9.737e-16 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-# We can also allow for different variances of parent and metabolite as error model
-fit.obs <- mkinfit(SFO_SFO, FOCUS_D, quiet = TRUE, error_model = "obs")
-# The two-component error model has significantly higher likelihood
-lrtest(fit.obs, fit.tc)
-#> Likelihood ratio test
-#> 
-#> Model 1: SFO_SFO with error model tc and fixed parameter(s) m1_0
-#> Model 2: SFO_SFO with error model obs and fixed parameter(s) m1_0
-#>   #Df  LogLik Df  Chisq Pr(>Chisq)    
-#> 1   6 -64.983                         
-#> 2   6 -96.936  0 63.907  < 2.2e-16 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-parms(fit.tc)
-#>       parent_0       k_parent           k_m1 f_parent_to_m1      sigma_low 
-#>   1.007343e+02   1.005562e-01   5.166712e-03   5.083933e-01   3.049883e-03 
-#>       rsd_high 
-#>   7.928118e-02 
-endpoints(fit.tc)
-#> $ff
-#>   parent_m1 parent_sink 
-#>   0.5083933   0.4916067 
-#> 
-#> $distimes
-#>             DT50      DT90
-#> parent   6.89313  22.89848
-#> m1     134.15634 445.65772
-#> 
-
-# We can show a quick (only one replication) benchmark for this case, as we
-# have several alternative solution methods for the model. We skip
-# uncompiled deSolve, as it is so slow. More benchmarks are found in the
-# benchmark vignette
-# \dontrun{
-if(require(rbenchmark)) {
-  benchmark(replications = 1, order = "relative", columns = c("test", "relative", "elapsed"),
-    deSolve_compiled = mkinfit(SFO_SFO, FOCUS_D, quiet = TRUE, error_model = "tc",
-      solution_type = "deSolve", use_compiled = TRUE),
-    eigen = mkinfit(SFO_SFO, FOCUS_D, quiet = TRUE, error_model = "tc",
-      solution_type = "eigen"),
-    analytical = mkinfit(SFO_SFO, FOCUS_D, quiet = TRUE, error_model = "tc",
-      solution_type = "analytical"))
-}
-#>               test relative elapsed
-#> 3       analytical    1.000   0.236
-#> 1 deSolve_compiled    1.263   0.298
-#> 2            eigen    2.373   0.560
-# }
-
-# Use stepwise fitting, using optimised parameters from parent only fit, FOMC-SFO
-# \dontrun{
-FOMC_SFO <- mkinmod(
-  parent = mkinsub("FOMC", "m1"),
-  m1 = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-fit.FOMC_SFO <- mkinfit(FOMC_SFO, FOCUS_D, quiet = TRUE)
-# Again, we get a warning and try a more sophisticated error model
-fit.FOMC_SFO.tc <- mkinfit(FOMC_SFO, FOCUS_D, quiet = TRUE, error_model = "tc")
-# This model has a higher likelihood, but not significantly so
-lrtest(fit.tc, fit.FOMC_SFO.tc)
-#> Likelihood ratio test
-#> 
-#> Model 1: FOMC_SFO with error model tc and fixed parameter(s) m1_0
-#> Model 2: SFO_SFO with error model tc and fixed parameter(s) m1_0
-#>   #Df  LogLik Df  Chisq Pr(>Chisq)
-#> 1   7 -64.829                     
-#> 2   6 -64.983 -1 0.3075     0.5792
-# Also, the missing standard error for log_beta and the t-tests for alpha
-# and beta indicate overparameterisation
-summary(fit.FOMC_SFO.tc, data = FALSE)
-#> Warning: NaNs produced
-#> Warning: NaNs produced
-#> Warning: diag(.) had 0 or NA entries; non-finite result is doubtful
-#> mkin version used for fitting:    1.2.3 
-#> R version used for fitting:       4.2.3 
-#> Date of fit:     Sun Apr 16 08:30:44 2023 
-#> Date of summary: Sun Apr 16 08:30:44 2023 
-#> 
-#> Equations:
-#> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent
-#> d_m1/dt = + f_parent_to_m1 * (alpha/beta) * 1/((time/beta) + 1) *
-#>            parent - k_m1 * m1
-#> 
-#> Model predictions using solution type deSolve 
-#> 
-#> Fitted using 3729 model solutions performed in 0.688 s
-#> 
-#> Error model: Two-component variance function 
-#> 
-#> Error model algorithm: d_3 
-#> Direct fitting and three-step fitting yield approximately the same likelihood 
-#> 
-#> Starting values for parameters to be optimised:
-#>                 value   type
-#> parent_0       100.75  state
-#> alpha            1.00 deparm
-#> beta            10.00 deparm
-#> k_m1             0.10 deparm
-#> f_parent_to_m1   0.50 deparm
-#> sigma_low        0.10  error
-#> rsd_high         0.10  error
-#> 
-#> Starting values for the transformed parameters actually optimised:
-#>                      value lower upper
-#> parent_0        100.750000  -Inf   Inf
-#> log_k_m1         -2.302585  -Inf   Inf
-#> f_parent_qlogis   0.000000  -Inf   Inf
-#> log_alpha         0.000000  -Inf   Inf
-#> log_beta          2.302585  -Inf   Inf
-#> sigma_low         0.100000     0   Inf
-#> rsd_high          0.100000     0   Inf
-#> 
-#> Fixed parameter values:
-#>      value  type
-#> m1_0     0 state
-#> 
-#> Results:
-#> 
-#>       AIC      BIC    logLik
-#>   143.658 155.1211 -64.82902
-#> 
-#> Optimised, transformed parameters with symmetric confidence intervals:
-#>                   Estimate Std. Error     Lower      Upper
-#> parent_0        101.600000  2.6400000 96.240000 107.000000
-#> log_k_m1         -5.284000  0.0929100 -5.474000  -5.095000
-#> f_parent_qlogis   0.001426  0.0767000 -0.155000   0.157800
-#> log_alpha         5.522000  0.0077320  5.506000   5.538000
-#> log_beta          7.806000        NaN       NaN        NaN
-#> sigma_low         0.002488  0.0002431  0.001992   0.002984
-#> rsd_high          0.079210  0.0093280  0.060180   0.098230
-#> 
-#> Parameter correlation:
-#>                  parent_0  log_k_m1 f_parent_qlogis log_alpha log_beta
-#> parent_0         1.000000 -0.095226        -0.76678   0.70544      NaN
-#> log_k_m1        -0.095226  1.000000         0.51432  -0.14387      NaN
-#> f_parent_qlogis -0.766780  0.514321         1.00000  -0.61396      NaN
-#> log_alpha        0.705444 -0.143872        -0.61396   1.00000      NaN
-#> log_beta              NaN       NaN             NaN       NaN        1
-#> sigma_low        0.016073  0.001586         0.01548   5.87007      NaN
-#> rsd_high         0.006626 -0.011700        -0.05357   0.04849      NaN
-#>                 sigma_low  rsd_high
-#> parent_0         0.016073  0.006626
-#> log_k_m1         0.001586 -0.011700
-#> f_parent_qlogis  0.015476 -0.053566
-#> log_alpha        5.870075  0.048487
-#> log_beta              NaN       NaN
-#> sigma_low        1.000000 -0.652558
-#> rsd_high        -0.652558  1.000000
-#> 
-#> Backtransformed parameters:
-#> Confidence intervals for internally transformed parameters are asymmetric.
-#> t-test (unrealistically) based on the assumption of normal distribution
-#> for estimators of untransformed parameters.
-#>                 Estimate t value    Pr(>t)     Lower     Upper
-#> parent_0       1.016e+02 32.7800 6.311e-26 9.624e+01 1.070e+02
-#> k_m1           5.072e-03 10.1200 1.216e-11 4.196e-03 6.130e-03
-#> f_parent_to_m1 5.004e-01 20.8300 4.317e-20 4.613e-01 5.394e-01
-#> alpha          2.502e+02  0.5624 2.889e-01 2.463e+02 2.542e+02
-#> beta           2.455e+03  0.5549 2.915e-01        NA        NA
-#> sigma_low      2.488e-03  0.4843 3.158e-01 1.992e-03 2.984e-03
-#> rsd_high       7.921e-02  8.4300 8.001e-10 6.018e-02 9.823e-02
-#> 
-#> FOCUS Chi2 error levels in percent:
-#>          err.min n.optim df
-#> All data   6.781       5 14
-#> parent     7.141       3  6
-#> m1         4.640       2  8
-#> 
-#> Resulting formation fractions:
-#>                 ff
-#> parent_m1   0.5004
-#> parent_sink 0.4996
-#> 
-#> Estimated disappearance times:
-#>           DT50  DT90 DT50back
-#> parent   6.812  22.7    6.834
-#> m1     136.661 454.0       NA
-
-# We can easily use starting parameters from the parent only fit (only for illustration)
-fit.FOMC = mkinfit("FOMC", FOCUS_2006_D, quiet = TRUE, error_model = "tc")
-fit.FOMC_SFO <- mkinfit(FOMC_SFO, FOCUS_D, quiet = TRUE,
-  parms.ini = fit.FOMC$bparms.ode, error_model = "tc")
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkinmod.html b/docs/dev/reference/mkinmod.html deleted file mode 100644 index 50ec64fa..00000000 --- a/docs/dev/reference/mkinmod.html +++ /dev/null @@ -1,426 +0,0 @@ - -Function to set up a kinetic model with one or more state variables — mkinmod • mkin - - -
-
- - - -
-
-
-

Function to set up a kinetic model with one or more state variables

- Source: R/mkinmod.R, R/mkinsub.R - -
- -
-

This function is usually called using a call to mkinsub() for each observed -variable, specifying the corresponding submodel as well as outgoing pathways -(see examples).

-

Print mkinmod objects in a way that the user finds his way to get to its -components.

-
- -
- 
mkinmod(
-  ...,
-  use_of_ff = "max",
-  name = NULL,
-  speclist = NULL,
-  quiet = FALSE,
-  verbose = FALSE,
-  dll_dir = NULL,
-  unload = FALSE,
-  overwrite = FALSE
-)
-
-# S3 method for mkinmod
-print(x, ...)
-
-mkinsub(submodel, to = NULL, sink = TRUE, full_name = NA)
-
- -
-

Arguments

-
...
-

For each observed variable, a list as obtained by mkinsub() -has to be specified as an argument (see examples). Currently, single -first order kinetics "SFO", indeterminate order rate equation kinetics -"IORE", or single first order with reversible binding "SFORB" are -implemented for all variables, while "FOMC", "DFOP", "HS" and "logistic" -can additionally be chosen for the first variable which is assumed to be -the source compartment. -Additionally, mkinsub() has an argument to, specifying names of -variables to which a transfer is to be assumed in the model. -If the argument use_of_ff is set to "min" -and the model for the compartment is "SFO" or "SFORB", an -additional mkinsub() argument can be sink = FALSE, effectively -fixing the flux to sink to zero. -In print.mkinmod, this argument is currently not used.

- - -
use_of_ff
-

Specification of the use of formation fractions in the -model equations and, if applicable, the coefficient matrix. If "max", -formation fractions are always used (default). If "min", a minimum use of -formation fractions is made, i.e. each first-order pathway to a metabolite -has its own rate constant.

- - -
name
-

A name for the model. Should be a valid R object name.

- - -
speclist
-

The specification of the observed variables and their -submodel types and pathways can be given as a single list using this -argument. Default is NULL.

- - -
quiet
-

Should messages be suppressed?

- - -
verbose
-

If TRUE, passed to inline::cfunction() if -applicable to give detailed information about the C function being built.

- - -
dll_dir
-

Directory where an DLL object, if generated internally by -inline::cfunction(), should be saved. The DLL will only be stored in a -permanent location for use in future sessions, if 'dll_dir' and 'name' -are specified. This is helpful if fit objects are cached e.g. by knitr, -as the cache remains functional across sessions if the DLL is stored in -a user defined location.

- - -
unload
-

If a DLL from the target location in 'dll_dir' is already -loaded, should that be unloaded first?

- - -
overwrite
-

If a file exists at the target DLL location in 'dll_dir', -should this be overwritten?

- - -
x
-

An mkinmod object.

- - -
submodel
-

Character vector of length one to specify the submodel type. -See mkinmod for the list of allowed submodel names.

- - -
to
-

Vector of the names of the state variable to which a -transformation shall be included in the model.

- - -
sink
-

Should a pathway to sink be included in the model in addition to -the pathways to other state variables?

- - -
full_name
-

An optional name to be used e.g. for plotting fits -performed with the model. You can use non-ASCII characters here, but then -your R code will not be portable, i.e. may produce unintended plot -results on other operating systems or system configurations.

- -
-
-

Value

- - -

A list of class mkinmod for use with mkinfit(), -containing, among others,

-
diffs
-

A vector of string representations of differential equations, one for -each modelling variable.

- -
map
-

A list containing named character vectors for each observed variable, -specifying the modelling variables by which it is represented.

- -
use_of_ff
-

The content of use_of_ff is passed on in this list component.

- -
deg_func
-

If generated, a function containing the solution of the degradation -model.

- -
coefmat
-

The coefficient matrix, if the system of differential equations can be -represented by one.

- -
cf
-

If generated, a compiled function calculating the derivatives as -returned by cfunction.

- - -

A list for use with mkinmod.

-
-
-

Details

-

For the definition of model types and their parameters, the equations given -in the FOCUS and NAFTA guidance documents are used.

-

For kinetic models with more than one observed variable, a symbolic solution -of the system of differential equations is included in the resulting -mkinmod object in some cases, speeding up the solution.

-

If a C compiler is found by pkgbuild::has_compiler() and there -is more than one observed variable in the specification, C code is generated -for evaluating the differential equations, compiled using -inline::cfunction() and added to the resulting mkinmod object.

-
-
-

Note

-

The IORE submodel is not well tested for metabolites. When using this -model for metabolites, you may want to read the note in the help -page to mkinfit.

-
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-

NAFTA Technical Working Group on Pesticides (not dated) Guidance for -Evaluating and Calculating Degradation Kinetics in Environmental Media

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-# Specify the SFO model (this is not needed any more, as we can now mkinfit("SFO", ...)
-SFO <- mkinmod(parent = mkinsub("SFO"))
-
-# One parent compound, one metabolite, both single first order
-SFO_SFO <- mkinmod(
-  parent = mkinsub("SFO", "m1"),
-  m1 = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-print(SFO_SFO)
-#> <mkinmod> model generated with
-#> Use of formation fractions $use_of_ff: max 
-#> Specification $spec:
-#> $parent
-#> $type: SFO; $to: m1; $sink: TRUE
-#> $m1
-#> $type: SFO; $sink: TRUE
-#> Coefficient matrix $coefmat available
-#> Compiled model $cf available
-#> Differential equations:
-#> d_parent/dt = - k_parent * parent
-#> d_m1/dt = + f_parent_to_m1 * k_parent * parent - k_m1 * m1
-
-# \dontrun{
- fit_sfo_sfo <- mkinfit(SFO_SFO, FOCUS_2006_D, quiet = TRUE, solution_type = "deSolve")
-#> Warning: Observations with value of zero were removed from the data
-
- # Now supplying compound names used for plotting, and write to user defined location
- # We need to choose a path outside the session tempdir because this gets removed
- DLL_dir <- "~/.local/share/mkin"
- if (!dir.exists(DLL_dir)) dir.create(DLL_dir)
- SFO_SFO.2 <- mkinmod(
-   parent = mkinsub("SFO", "m1", full_name = "Test compound"),
-   m1 = mkinsub("SFO", full_name = "Metabolite M1"),
-   name = "SFO_SFO", dll_dir = DLL_dir, unload = TRUE, overwrite = TRUE)
-#> Temporary DLL for differentials generated and loaded
-#> Copied DLL from /tmp/RtmpiGRJ6t/file5c7f7365e02a0.so to /home/jranke/.local/share/mkin/SFO_SFO.so
-# Now we can save the model and restore it in a new session
-saveRDS(SFO_SFO.2, file = "~/SFO_SFO.rds")
-# Terminate the R session here if you would like to check, and then do
-library(mkin)
-SFO_SFO.3 <- readRDS("~/SFO_SFO.rds")
-fit_sfo_sfo <- mkinfit(SFO_SFO.3, FOCUS_2006_D, quiet = TRUE, solution_type = "deSolve")
-#> Warning: Observations with value of zero were removed from the data
-
-# Show details of creating the C function
-SFO_SFO <- mkinmod(
-  parent = mkinsub("SFO", "m1"),
-  m1 = mkinsub("SFO"), verbose = TRUE)
-#> Program source:
-#>   1: #include <R.h>
-#>   2: 
-#>   3: 
-#>   4: static double parms [3];
-#>   5: #define k_parent parms[0]
-#>   6: #define f_parent_to_m1 parms[1]
-#>   7: #define k_m1 parms[2]
-#>   8: 
-#>   9: void initpar(void (* odeparms)(int *, double *)) {
-#>  10:     int N = 3;
-#>  11:     odeparms(&N, parms);
-#>  12: }
-#>  13: 
-#>  14: 
-#>  15: void diffs ( int * n, double * t, double * y, double * f, double * rpar, int * ipar ) {
-#>  16: 
-#>  17: f[0] = - k_parent * y[0];
-#>  18: f[1] = + f_parent_to_m1 * k_parent * y[0] - k_m1 * y[1];
-#>  19: }
-#> Temporary DLL for differentials generated and loaded
-
-# The symbolic solution which is available in this case is not
-# made for human reading but for speed of computation
-SFO_SFO$deg_func
-#> function (observed, odeini, odeparms) 
-#> {
-#>     predicted <- numeric(0)
-#>     with(as.list(odeparms), {
-#>         t <- observed[observed$name == "parent", "time"]
-#>         predicted <<- c(predicted, SFO.solution(t, odeini["parent"], 
-#>             k_parent))
-#>         t <- observed[observed$name == "m1", "time"]
-#>         predicted <<- c(predicted, (((k_m1 - k_parent) * odeini["m1"] - 
-#>             f_parent_to_m1 * k_parent * odeini["parent"]) * exp(-k_m1 * 
-#>             t) + f_parent_to_m1 * k_parent * odeini["parent"] * 
-#>             exp(-k_parent * t))/(k_m1 - k_parent))
-#>     })
-#>     return(predicted)
-#> }
-#> <environment: 0x555558bd6708>
-
-# If we have several parallel metabolites
-# (compare tests/testthat/test_synthetic_data_for_UBA_2014.R)
-m_synth_DFOP_par <- mkinmod(
- parent = mkinsub("DFOP", c("M1", "M2")),
- M1 = mkinsub("SFO"),
- M2 = mkinsub("SFO"),
- quiet = TRUE)
-
-fit_DFOP_par_c <- mkinfit(m_synth_DFOP_par,
-  synthetic_data_for_UBA_2014[[12]]$data,
-  quiet = TRUE)
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkinparplot-1.png b/docs/dev/reference/mkinparplot-1.png deleted file mode 100644 index 6e7bf34f..00000000 Binary files a/docs/dev/reference/mkinparplot-1.png and /dev/null differ diff --git a/docs/dev/reference/mkinparplot.html b/docs/dev/reference/mkinparplot.html deleted file mode 100644 index f7d404ef..00000000 --- a/docs/dev/reference/mkinparplot.html +++ /dev/null @@ -1,177 +0,0 @@ - -Function to plot the confidence intervals obtained using mkinfit — mkinparplot • mkin - - -
-
- - - -
-
-
-

Function to plot the confidence intervals obtained using mkinfit

- Source: R/mkinparplot.R - -
- -
-

This function plots the confidence intervals for the parameters fitted using -mkinfit.

-
- -
- 
mkinparplot(object)
-
- -
-

Arguments

-
object
-

A fit represented in an mkinfit object.

- -
-
-

Value

- - -

Nothing is returned by this function, as it is called for its side -effect, namely to produce a plot.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-# \dontrun{
-model <- mkinmod(
-  T245 = mkinsub("SFO", to = c("phenol"), sink = FALSE),
-  phenol = mkinsub("SFO", to = c("anisole")),
-  anisole = mkinsub("SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-fit <- mkinfit(model, subset(mccall81_245T, soil == "Commerce"), quiet = TRUE)
-#> Warning: Observations with value of zero were removed from the data
-#> Warning: Optimisation did not converge:
-#> false convergence (8)
-mkinparplot(fit)
-
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkinplot.html b/docs/dev/reference/mkinplot.html deleted file mode 100644 index d83ea3f4..00000000 --- a/docs/dev/reference/mkinplot.html +++ /dev/null @@ -1,162 +0,0 @@ - -Plot the observed data and the fitted model of an mkinfit object — mkinplot • mkin - - -
-
- - - -
-
-
-

Plot the observed data and the fitted model of an mkinfit object

- Source: R/plot.mkinfit.R - -
- -
-

Deprecated function. It now only calls the plot method -plot.mkinfit.

-
- -
- 
mkinplot(fit, ...)
-
- -
-

Arguments

-
fit
-

an object of class mkinfit.

- - -
...
-

further arguments passed to plot.mkinfit.

- -
-
-

Value

- - -

The function is called for its side effect.

-
-
-

Author

-

Johannes Ranke

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkinpredict.html b/docs/dev/reference/mkinpredict.html deleted file mode 100644 index 7d8e7c26..00000000 --- a/docs/dev/reference/mkinpredict.html +++ /dev/null @@ -1,437 +0,0 @@ - -Produce predictions from a kinetic model using specific parameters — mkinpredict • mkin - - -
-
- - - -
-
-
-

Produce predictions from a kinetic model using specific parameters

- Source: R/mkinpredict.R - -
- -
-

This function produces a time series for all the observed variables in a -kinetic model as specified by mkinmod, using a specific set of -kinetic parameters and initial values for the state variables.

-
- -
- 
mkinpredict(x, odeparms, odeini, outtimes, ...)
-
-# S3 method for mkinmod
-mkinpredict(
-  x,
-  odeparms = c(k_parent_sink = 0.1),
-  odeini = c(parent = 100),
-  outtimes = seq(0, 120, by = 0.1),
-  solution_type = "deSolve",
-  use_compiled = "auto",
-  use_symbols = FALSE,
-  method.ode = "lsoda",
-  atol = 1e-08,
-  rtol = 1e-10,
-  maxsteps = 20000L,
-  map_output = TRUE,
-  na_stop = TRUE,
-  ...
-)
-
-# S3 method for mkinfit
-mkinpredict(
-  x,
-  odeparms = x$bparms.ode,
-  odeini = x$bparms.state,
-  outtimes = seq(0, 120, by = 0.1),
-  solution_type = "deSolve",
-  use_compiled = "auto",
-  method.ode = "lsoda",
-  atol = 1e-08,
-  rtol = 1e-10,
-  map_output = TRUE,
-  ...
-)
-
- -
-

Arguments

-
x
-

A kinetic model as produced by mkinmod, or a kinetic fit as -fitted by mkinfit. In the latter case, the fitted parameters are used for -the prediction.

- - -
odeparms
-

A numeric vector specifying the parameters used in the -kinetic model, which is generally defined as a set of ordinary differential -equations.

- - -
odeini
-

A numeric vector containing the initial values of the state -variables of the model. Note that the state variables can differ from the -observed variables, for example in the case of the SFORB model.

- - -
outtimes
-

A numeric vector specifying the time points for which model -predictions should be generated.

- - -
...
-

Further arguments passed to the ode solver in case such a -solver is used.

- - -
solution_type
-

The method that should be used for producing the -predictions. This should generally be "analytical" if there is only one -observed variable, and usually "deSolve" in the case of several observed -variables. The third possibility "eigen" is fast in comparison to uncompiled -ODE models, but not applicable to some models, e.g. using FOMC for the -parent compound.

- - -
use_compiled
-

If set to FALSE, no compiled version of the -mkinmod model is used, even if is present.

- - -
use_symbols
-

If set to TRUE (default), symbol info present in -the mkinmod object is used if available for accessing compiled code

- - -
method.ode
-

The solution method passed via mkinpredict to ode] in -case the solution type is "deSolve" and we are not using compiled code. -When using compiled code, only lsoda is supported.

- - -
atol
-

Absolute error tolerance, passed to the ode solver.

- - -
rtol
-

Absolute error tolerance, passed to the ode solver.

- - -
maxsteps
-

Maximum number of steps, passed to the ode solver.

- - -
map_output
-

Boolean to specify if the output should list values for -the observed variables (default) or for all state variables (if set to -FALSE). Setting this to FALSE has no effect for analytical solutions, -as these always return mapped output.

- - -
na_stop
-

Should it be an error if ode returns NaN values

- -
-
-

Value

- - -

A matrix with the numeric solution in wide format

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-SFO <- mkinmod(degradinol = mkinsub("SFO"))
-# Compare solution types
-mkinpredict(SFO, c(k_degradinol = 0.3), c(degradinol = 100), 0:20,
-      solution_type = "analytical")
-#>    time  degradinol
-#> 0     0 100.0000000
-#> 1     1  74.0818221
-#> 2     2  54.8811636
-#> 3     3  40.6569660
-#> 4     4  30.1194212
-#> 5     5  22.3130160
-#> 6     6  16.5298888
-#> 7     7  12.2456428
-#> 8     8   9.0717953
-#> 9     9   6.7205513
-#> 10   10   4.9787068
-#> 11   11   3.6883167
-#> 12   12   2.7323722
-#> 13   13   2.0241911
-#> 14   14   1.4995577
-#> 15   15   1.1108997
-#> 16   16   0.8229747
-#> 17   17   0.6096747
-#> 18   18   0.4516581
-#> 19   19   0.3345965
-#> 20   20   0.2478752
-mkinpredict(SFO, c(k_degradinol = 0.3), c(degradinol = 100), 0:20,
-      solution_type = "deSolve")
-#>    time  degradinol
-#> 0     0 100.0000000
-#> 1     1  74.0818221
-#> 2     2  54.8811636
-#> 3     3  40.6569660
-#> 4     4  30.1194212
-#> 5     5  22.3130160
-#> 6     6  16.5298888
-#> 7     7  12.2456428
-#> 8     8   9.0717953
-#> 9     9   6.7205513
-#> 10   10   4.9787068
-#> 11   11   3.6883167
-#> 12   12   2.7323722
-#> 13   13   2.0241911
-#> 14   14   1.4995577
-#> 15   15   1.1108996
-#> 16   16   0.8229747
-#> 17   17   0.6096747
-#> 18   18   0.4516581
-#> 19   19   0.3345965
-#> 20   20   0.2478752
-mkinpredict(SFO, c(k_degradinol = 0.3), c(degradinol = 100), 0:20,
-      solution_type = "deSolve", use_compiled = FALSE)
-#>    time  degradinol
-#> 0     0 100.0000000
-#> 1     1  74.0818221
-#> 2     2  54.8811636
-#> 3     3  40.6569660
-#> 4     4  30.1194212
-#> 5     5  22.3130160
-#> 6     6  16.5298888
-#> 7     7  12.2456428
-#> 8     8   9.0717953
-#> 9     9   6.7205513
-#> 10   10   4.9787068
-#> 11   11   3.6883167
-#> 12   12   2.7323722
-#> 13   13   2.0241911
-#> 14   14   1.4995577
-#> 15   15   1.1108996
-#> 16   16   0.8229747
-#> 17   17   0.6096747
-#> 18   18   0.4516581
-#> 19   19   0.3345965
-#> 20   20   0.2478752
-mkinpredict(SFO, c(k_degradinol = 0.3), c(degradinol = 100), 0:20,
-      solution_type = "eigen")
-#>    time  degradinol
-#> 0     0 100.0000000
-#> 1     1  74.0818221
-#> 2     2  54.8811636
-#> 3     3  40.6569660
-#> 4     4  30.1194212
-#> 5     5  22.3130160
-#> 6     6  16.5298888
-#> 7     7  12.2456428
-#> 8     8   9.0717953
-#> 9     9   6.7205513
-#> 10   10   4.9787068
-#> 11   11   3.6883167
-#> 12   12   2.7323722
-#> 13   13   2.0241911
-#> 14   14   1.4995577
-#> 15   15   1.1108997
-#> 16   16   0.8229747
-#> 17   17   0.6096747
-#> 18   18   0.4516581
-#> 19   19   0.3345965
-#> 20   20   0.2478752
-
-# Compare integration methods to analytical solution
-mkinpredict(SFO, c(k_degradinol = 0.3), c(degradinol = 100), 0:20,
-      solution_type = "analytical")[21,]
-#>       time degradinol 
-#> 20.0000000  0.2478752 
-mkinpredict(SFO, c(k_degradinol = 0.3), c(degradinol = 100), 0:20,
-      method = "lsoda", use_compiled = FALSE)[21,]
-#>       time degradinol 
-#> 20.0000000  0.2478752 
-mkinpredict(SFO, c(k_degradinol = 0.3), c(degradinol = 100), 0:20,
-      method = "ode45", use_compiled = FALSE)[21,]
-#>       time degradinol 
-#> 20.0000000  0.2478752 
-mkinpredict(SFO, c(k_degradinol = 0.3), c(degradinol = 100), 0:20,
-      method = "rk4", use_compiled = FALSE)[21,]
-#>       time degradinol 
-#> 20.0000000  0.2480043 
-# rk4 is not as precise here
-
-# The number of output times used to make a lot of difference until the
-# default for atol was adjusted
-mkinpredict(SFO, c(k_degradinol = 0.3), c(degradinol = 100),
-      seq(0, 20, by = 0.1))[201,]
-#>       time degradinol 
-#> 20.0000000  0.2478752 
-mkinpredict(SFO, c(k_degradinol = 0.3), c(degradinol = 100),
-      seq(0, 20, by = 0.01))[2001,]
-#>       time degradinol 
-#> 20.0000000  0.2478752 
-
-# Comparison of the performance of solution types
-SFO_SFO = mkinmod(parent = list(type = "SFO", to = "m1"),
-                  m1 = list(type = "SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-if(require(rbenchmark)) {
-  benchmark(replications = 10, order = "relative", columns = c("test", "relative", "elapsed"),
-    eigen = mkinpredict(SFO_SFO,
-      c(k_parent = 0.15, f_parent_to_m1 = 0.5, k_m1 = 0.01),
-      c(parent = 100, m1 = 0), seq(0, 20, by = 0.1),
-      solution_type = "eigen")[201,],
-    deSolve_compiled = mkinpredict(SFO_SFO,
-      c(k_parent = 0.15, f_parent_to_m1 = 0.5, k_m1 = 0.01),
-      c(parent = 100, m1 = 0), seq(0, 20, by = 0.1),
-      solution_type = "deSolve")[201,],
-    deSolve = mkinpredict(SFO_SFO,
-      c(k_parent = 0.15, f_parent_to_m1 = 0.5, k_m1 = 0.01),
-      c(parent = 100, m1 = 0), seq(0, 20, by = 0.1),
-      solution_type = "deSolve", use_compiled = FALSE)[201,],
-    analytical = mkinpredict(SFO_SFO,
-      c(k_parent = 0.15, f_parent_to_m1 = 0.5, k_m1 = 0.01),
-      c(parent = 100, m1 = 0), seq(0, 20, by = 0.1),
-      solution_type = "analytical", use_compiled = FALSE)[201,])
-}
-#> Loading required package: rbenchmark
-#>               test relative elapsed
-#> 2 deSolve_compiled     1.00   0.004
-#> 1            eigen     4.00   0.016
-#> 4       analytical     4.25   0.017
-#> 3          deSolve    40.75   0.163
-
-# \dontrun{
-  # Predict from a fitted model
-  f <- mkinfit(SFO_SFO, FOCUS_2006_C, quiet = TRUE)
-  f <- mkinfit(SFO_SFO, FOCUS_2006_C, quiet = TRUE, solution_type = "deSolve")
-  head(mkinpredict(f))
-#> Error in !is.null(x$symbols) & use_symbols: operations are possible only for numeric, logical or complex types
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mkinresplot-1.png b/docs/dev/reference/mkinresplot-1.png deleted file mode 100644 index 7c64d0f0..00000000 Binary files a/docs/dev/reference/mkinresplot-1.png and /dev/null differ diff --git a/docs/dev/reference/mkinresplot.html b/docs/dev/reference/mkinresplot.html deleted file mode 100644 index e73ac93c..00000000 --- a/docs/dev/reference/mkinresplot.html +++ /dev/null @@ -1,248 +0,0 @@ - -Function to plot residuals stored in an mkin object — mkinresplot • mkin - - -
-
- - - -
-
-
-

Function to plot residuals stored in an mkin object

- Source: R/mkinresplot.R - -
- -
-

This function plots the residuals for the specified subset of the observed -variables from an mkinfit object. A combined plot of the fitted model and -the residuals can be obtained using plot.mkinfit using the -argument show_residuals = TRUE.

-
- -
- 
mkinresplot(
-  object,
-  obs_vars = names(object$mkinmod$map),
-  xlim = c(0, 1.1 * max(object$data$time)),
-  standardized = FALSE,
-  xlab = "Time",
-  ylab = ifelse(standardized, "Standardized residual", "Residual"),
-  maxabs = "auto",
-  legend = TRUE,
-  lpos = "topright",
-  col_obs = "auto",
-  pch_obs = "auto",
-  frame = TRUE,
-  ...
-)
-
- -
-

Arguments

-
object
-

A fit represented in an mkinfit object.

- - -
obs_vars
-

A character vector of names of the observed variables for -which residuals should be plotted. Defaults to all observed variables in -the model

- - -
xlim
-

plot range in x direction.

- - -
standardized
-

Should the residuals be standardized by dividing by the -standard deviation given by the error model of the fit?

- - -
xlab
-

Label for the x axis.

- - -
ylab
-

Label for the y axis.

- - -
maxabs
-

Maximum absolute value of the residuals. This is used for the -scaling of the y axis and defaults to "auto".

- - -
legend
-

Should a legend be plotted?

- - -
lpos
-

Where should the legend be placed? Default is "topright". Will -be passed on to legend.

- - -
col_obs
-

Colors for the observed variables.

- - -
pch_obs
-

Symbols to be used for the observed variables.

- - -
frame
-

Should a frame be drawn around the plots?

- - -
...
-

further arguments passed to plot.

- -
-
-

Value

- - -

Nothing is returned by this function, as it is called for its side -effect, namely to produce a plot.

-
-
-

See also

-

mkinplot, for a way to plot the data and the fitted -lines of the mkinfit object, and plot_res for a function -combining the plot of the fit and the residual plot.

-
-
-

Author

-

Johannes Ranke and Katrin Lindenberger

-
- -
-

Examples

- 

-model <- mkinmod(parent = mkinsub("SFO", "m1"), m1 = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-fit <- mkinfit(model, FOCUS_2006_D, quiet = TRUE)
-#> Warning: Observations with value of zero were removed from the data
-mkinresplot(fit, "m1")
-
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/mmkin-1.png b/docs/dev/reference/mmkin-1.png deleted file mode 100644 index dae64316..00000000 Binary files a/docs/dev/reference/mmkin-1.png and /dev/null differ diff --git a/docs/dev/reference/mmkin-2.png b/docs/dev/reference/mmkin-2.png deleted file mode 100644 index b281cd7e..00000000 Binary files a/docs/dev/reference/mmkin-2.png and /dev/null differ diff --git a/docs/dev/reference/mmkin-3.png b/docs/dev/reference/mmkin-3.png deleted file mode 100644 index 23b0725c..00000000 Binary files a/docs/dev/reference/mmkin-3.png and /dev/null differ diff --git a/docs/dev/reference/mmkin-4.png b/docs/dev/reference/mmkin-4.png deleted file mode 100644 index 11eae1f9..00000000 Binary files a/docs/dev/reference/mmkin-4.png and /dev/null differ diff --git a/docs/dev/reference/mmkin-5.png b/docs/dev/reference/mmkin-5.png deleted file mode 100644 index e88bd59f..00000000 Binary files a/docs/dev/reference/mmkin-5.png and /dev/null differ diff --git a/docs/dev/reference/mmkin.html b/docs/dev/reference/mmkin.html deleted file mode 100644 index 64623f20..00000000 --- a/docs/dev/reference/mmkin.html +++ /dev/null @@ -1,289 +0,0 @@ - -Fit one or more kinetic models with one or more state variables to one or -more datasets — mmkin • mkin - - -
-
- - - -
-
-
-

Fit one or more kinetic models with one or more state variables to one or -more datasets

- Source: R/mmkin.R - -
- -
-

This function calls mkinfit on all combinations of models and -datasets specified in its first two arguments.

-
- -
- 
mmkin(
-  models = c("SFO", "FOMC", "DFOP"),
-  datasets,
-  cores = if (Sys.info()["sysname"] == "Windows") 1 else parallel::detectCores(),
-  cluster = NULL,
-  ...
-)
-
-# S3 method for mmkin
-print(x, ...)
-
- -
-

Arguments

-
models
-

Either a character vector of shorthand names like -c("SFO", "FOMC", "DFOP", "HS", "SFORB"), or an optionally named -list of mkinmod objects.

- - -
datasets
-

An optionally named list of datasets suitable as observed -data for mkinfit.

- - -
cores
-

The number of cores to be used for multicore processing. This -is only used when the cluster argument is NULL. On Windows -machines, cores > 1 is not supported, you need to use the cluster -argument to use multiple logical processors. Per default, all cores -detected by parallel::detectCores() are used, except on Windows where -the default is 1.

- - -
cluster
-

A cluster as returned by makeCluster to be used -for parallel execution.

- - -
...
-

Not used.

- - -
x
-

An mmkin object.

- -
-
-

Value

- - -

A two-dimensional array of mkinfit

- - -

objects and/or try-errors that can be indexed using the model names for the -first index (row index) and the dataset names for the second index (column -index).

-
-
-

See also

-

[.mmkin for subsetting, plot.mmkin for -plotting.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-# \dontrun{
-m_synth_SFO_lin <- mkinmod(parent = mkinsub("SFO", "M1"),
-                           M1 = mkinsub("SFO", "M2"),
-                           M2 = mkinsub("SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-m_synth_FOMC_lin <- mkinmod(parent = mkinsub("FOMC", "M1"),
-                            M1 = mkinsub("SFO", "M2"),
-                            M2 = mkinsub("SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-models <- list(SFO_lin = m_synth_SFO_lin, FOMC_lin = m_synth_FOMC_lin)
-datasets <- lapply(synthetic_data_for_UBA_2014[1:3], function(x) x$data)
-names(datasets) <- paste("Dataset", 1:3)
-
-time_default <- system.time(fits.0 <- mmkin(models, datasets, quiet = TRUE))
-time_1 <- system.time(fits.4 <- mmkin(models, datasets, cores = 1, quiet = TRUE))
-
-time_default
-#>    user  system elapsed 
-#>   1.560   0.668   0.742 
-time_1
-#>    user  system elapsed 
-#>   2.033   0.004   2.037 
-
-endpoints(fits.0[["SFO_lin", 2]])
-#> $ff
-#>   parent_M1 parent_sink       M1_M2     M1_sink 
-#>   0.7340481   0.2659519   0.7505683   0.2494317 
-#> 
-#> $distimes
-#>             DT50       DT90
-#> parent  0.877769   2.915885
-#> M1      2.325744   7.725956
-#> M2     33.720100 112.015749
-#> 
-
-# plot.mkinfit handles rows or columns of mmkin result objects
-plot(fits.0[1, ])
-
-plot(fits.0[1, ], obs_var = c("M1", "M2"))
-
-plot(fits.0[, 1])
-
-# Use double brackets to extract a single mkinfit object, which will be plotted
-# by plot.mkinfit and can be plotted using plot_sep
-plot(fits.0[[1, 1]], sep_obs = TRUE, show_residuals = TRUE, show_errmin = TRUE)
-
-plot_sep(fits.0[[1, 1]])
-# Plotting with mmkin (single brackets, extracting an mmkin object) does not
-# allow to plot the observed variables separately
-plot(fits.0[1, 1])
-
-
-# On Windows, we can use multiple cores by making a cluster first
-cl <- parallel::makePSOCKcluster(12)
-f <- mmkin(c("SFO", "FOMC", "DFOP"),
-  list(A = FOCUS_2006_A, B = FOCUS_2006_B, C = FOCUS_2006_C, D = FOCUS_2006_D),
-  cluster = cl, quiet = TRUE)
-print(f)
-#> <mmkin> object
-#> Status of individual fits:
-#> 
-#>       dataset
-#> model  A  B  C  D 
-#>   SFO  OK OK OK OK
-#>   FOMC OK OK OK OK
-#>   DFOP OK OK OK OK
-#> 
-#> OK: No warnings
-# We get false convergence for the FOMC fit to FOCUS_2006_A because this
-# dataset is really SFO, and the FOMC fit is overparameterised
-parallel::stopCluster(cl)
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/multistart-1.png b/docs/dev/reference/multistart-1.png deleted file mode 100644 index c7937d67..00000000 Binary files a/docs/dev/reference/multistart-1.png and /dev/null differ diff --git a/docs/dev/reference/multistart-2.png b/docs/dev/reference/multistart-2.png deleted file mode 100644 index b6e29ba5..00000000 Binary files a/docs/dev/reference/multistart-2.png and /dev/null differ diff --git a/docs/dev/reference/multistart.html b/docs/dev/reference/multistart.html deleted file mode 100644 index 6fc88621..00000000 --- a/docs/dev/reference/multistart.html +++ /dev/null @@ -1,259 +0,0 @@ - -Perform a hierarchical model fit with multiple starting values — multistart • mkin - - -
-
- - - -
-
-
-

Perform a hierarchical model fit with multiple starting values

- Source: R/multistart.R - -
- -
-

The purpose of this method is to check if a certain algorithm for fitting -nonlinear hierarchical models (also known as nonlinear mixed-effects models) -will reliably yield results that are sufficiently similar to each other, if -started with a certain range of reasonable starting parameters. It is -inspired by the article on practical identifiabiliy in the frame of nonlinear -mixed-effects models by Duchesne et al (2021).

-
- -
- 
multistart(
-  object,
-  n = 50,
-  cores = if (Sys.info()["sysname"] == "Windows") 1 else parallel::detectCores(),
-  cluster = NULL,
-  ...
-)
-
-# S3 method for saem.mmkin
-multistart(object, n = 50, cores = 1, cluster = NULL, ...)
-
-# S3 method for multistart
-print(x, ...)
-
-best(object, ...)
-
-# S3 method for default
-best(object, ...)
-
-which.best(object, ...)
-
-# S3 method for default
-which.best(object, ...)
-
- -
-

Arguments

-
object
-

The fit object to work with

- - -
n
-

How many different combinations of starting parameters should be -used?

- - -
cores
-

How many fits should be run in parallel (only on posix platforms)?

- - -
cluster
-

A cluster as returned by parallel::makeCluster to be used -for parallel execution.

- - -
...
-

Passed to the update function.

- - -
x
-

The multistart object to print

- -
-
-

Value

- - -

A list of saem.mmkin objects, with class attributes -'multistart.saem.mmkin' and 'multistart'.

- - -

The object with the highest likelihood

- - -

The index of the object with the highest likelihood

-
-
-

References

-

Duchesne R, Guillemin A, Gandrillon O, Crauste F. Practical -identifiability in the frame of nonlinear mixed effects models: the example -of the in vitro erythropoiesis. BMC Bioinformatics. 2021 Oct 4;22(1):478. -doi: 10.1186/s12859-021-04373-4.

-
-
-

See also

-

parplot, llhist

-
- -
-

Examples

- 
# \dontrun{
-library(mkin)
-dmta_ds <- lapply(1:7, function(i) {
-  ds_i <- dimethenamid_2018$ds[[i]]$data
-  ds_i[ds_i$name == "DMTAP", "name"] <-  "DMTA"
-  ds_i$time <- ds_i$time * dimethenamid_2018$f_time_norm[i]
-  ds_i
-})
-names(dmta_ds) <- sapply(dimethenamid_2018$ds, function(ds) ds$title)
-dmta_ds[["Elliot"]] <- rbind(dmta_ds[["Elliot 1"]], dmta_ds[["Elliot 2"]])
-dmta_ds[["Elliot 1"]] <- dmta_ds[["Elliot 2"]] <- NULL
-
-f_mmkin <- mmkin("DFOP", dmta_ds, error_model = "tc", cores = 7, quiet = TRUE)
-f_saem_full <- saem(f_mmkin)
-f_saem_full_multi <- multistart(f_saem_full, n = 16, cores = 16)
-parplot(f_saem_full_multi, lpos = "topleft")
-
-illparms(f_saem_full)
-#> [1] "sd(log_k2)"
-
-f_saem_reduced <- update(f_saem_full, no_random_effect = "log_k2")
-illparms(f_saem_reduced)
-# On Windows, we need to create a PSOCK cluster first and refer to it
-# in the call to multistart()
-library(parallel)
-cl <- makePSOCKcluster(12)
-f_saem_reduced_multi <- multistart(f_saem_reduced, n = 16, cluster = cl)
-parplot(f_saem_reduced_multi, lpos = "topright", ylim = c(0.5, 2))
-
-stopCluster(cl)
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/nafta-1.png b/docs/dev/reference/nafta-1.png deleted file mode 100644 index 98d4246c..00000000 Binary files a/docs/dev/reference/nafta-1.png and /dev/null differ diff --git a/docs/dev/reference/nafta.html b/docs/dev/reference/nafta.html deleted file mode 100644 index 6d568718..00000000 --- a/docs/dev/reference/nafta.html +++ /dev/null @@ -1,259 +0,0 @@ - -Evaluate parent kinetics using the NAFTA guidance — nafta • mkin - - -
-
- - - -
-
-
-

Evaluate parent kinetics using the NAFTA guidance

- Source: R/nafta.R - -
- -
-

The function fits the SFO, IORE and DFOP models using mmkin -and returns an object of class nafta that has methods for printing -and plotting.

-

Print nafta objects. The results for the three models are printed in the -order of increasing model complexity, i.e. SFO, then IORE, and finally DFOP.

-
- -
- 
nafta(ds, title = NA, quiet = FALSE, ...)
-
-# S3 method for nafta
-print(x, quiet = TRUE, digits = 3, ...)
-
- -
-

Source

-

NAFTA (2011) Guidance for evaluating and calculating degradation -kinetics in environmental media. NAFTA Technical Working Group on -Pesticides -https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation -accessed 2019-02-22

-

US EPA (2015) Standard Operating Procedure for Using the NAFTA Guidance to -Calculate Representative Half-life Values and Characterizing Pesticide -Degradation -https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance

-
-
-

Arguments

-
ds
-

A dataframe that must contain one variable called "time" with the -time values specified by the time argument, one column called -"name" with the grouping of the observed values, and finally one column of -observed values called "value".

- - -
title
-

Optional title of the dataset

- - -
quiet
-

Should the evaluation text be shown?

- - -
...
-

Further arguments passed to mmkin (not for the -printing method).

- - -
x
-

An nafta object.

- - -
digits
-

Number of digits to be used for printing parameters and -dissipation times.

- -
-
-

Value

- - -

An list of class nafta. The list element named "mmkin" is the -mmkin object containing the fits of the three models. The -list element named "title" contains the title of the dataset used. The -list element "data" contains the dataset used in the fits.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-  nafta_evaluation <- nafta(NAFTA_SOP_Appendix_D, cores = 1)
-#> The SFO model is rejected as S_SFO is equal or higher than the critical value S_c
-#> The representative half-life of the IORE model is longer than the one corresponding
-#> to the terminal degradation rate found with the DFOP model.
-#> The representative half-life obtained from the DFOP model may be used
-  print(nafta_evaluation)
-#> Sums of squares:
-#>       SFO      IORE      DFOP 
-#> 1378.6832  615.7730  517.8836 
-#> 
-#> Critical sum of squares for checking the SFO model:
-#> [1] 717.4598
-#> 
-#> Parameters:
-#> $SFO
-#>          Estimate   Pr(>t)    Lower   Upper
-#> parent_0  83.7558 1.80e-14 77.18268 90.3288
-#> k_parent   0.0017 7.43e-05  0.00112  0.0026
-#> sigma      8.7518 1.22e-05  5.64278 11.8608
-#> 
-#> $IORE
-#>                Estimate Pr(>t)    Lower    Upper
-#> parent_0       9.69e+01     NA 8.88e+01 1.05e+02
-#> k__iore_parent 8.40e-14     NA 1.79e-18 3.94e-09
-#> N_parent       6.68e+00     NA 4.19e+00 9.17e+00
-#> sigma          5.85e+00     NA 3.76e+00 7.94e+00
-#> 
-#> $DFOP
-#>          Estimate   Pr(>t)    Lower    Upper
-#> parent_0 9.76e+01 1.94e-13 9.02e+01 1.05e+02
-#> k1       4.24e-02 5.92e-03 2.03e-02 8.88e-02
-#> k2       8.24e-04 6.48e-03 3.89e-04 1.75e-03
-#> g        2.88e-01 2.47e-05 1.95e-01 4.03e-01
-#> sigma    5.36e+00 2.22e-05 3.43e+00 7.30e+00
-#> 
-#> 
-#> DTx values:
-#>      DT50    DT90 DT50_rep
-#> SFO   407    1350      407
-#> IORE  541 5190000  1560000
-#> DFOP  429    2380      841
-#> 
-#> Representative half-life:
-#> [1] 841.41
-  plot(nafta_evaluation)
-
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/nlme-1.png b/docs/dev/reference/nlme-1.png deleted file mode 100644 index 9583da2a..00000000 Binary files a/docs/dev/reference/nlme-1.png and /dev/null differ diff --git a/docs/dev/reference/nlme-2.png b/docs/dev/reference/nlme-2.png deleted file mode 100644 index e941687c..00000000 Binary files a/docs/dev/reference/nlme-2.png and /dev/null differ diff --git a/docs/dev/reference/nlme.html b/docs/dev/reference/nlme.html deleted file mode 100644 index 81c45ab9..00000000 --- a/docs/dev/reference/nlme.html +++ /dev/null @@ -1,244 +0,0 @@ - -Helper functions to create nlme models from mmkin row objects — nlme_function • mkin - - -
-
- - - -
-
-
-

Helper functions to create nlme models from mmkin row objects

- Source: R/nlme.R - -
- -
-

These functions facilitate setting up a nonlinear mixed effects model for -an mmkin row object. An mmkin row object is essentially a list of mkinfit -objects that have been obtained by fitting the same model to a list of -datasets. They are used internally by the nlme.mmkin() method.

-
- -
- 
nlme_function(object)
-
-nlme_data(object)
-
- -
-

Arguments

-
object
-

An mmkin row object containing several fits of the same model to different datasets

- -
-
-

Value

- - -

A function that can be used with nlme

- - -

A groupedData object

-
-
-

See also

-

nlme.mmkin

-
- -
-

Examples

- 
sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-m_SFO <- mkinmod(parent = mkinsub("SFO"))
-d_SFO_1 <- mkinpredict(m_SFO,
-  c(k_parent = 0.1),
-  c(parent = 98), sampling_times)
-d_SFO_1_long <- mkin_wide_to_long(d_SFO_1, time = "time")
-d_SFO_2 <- mkinpredict(m_SFO,
-  c(k_parent = 0.05),
-  c(parent = 102), sampling_times)
-d_SFO_2_long <- mkin_wide_to_long(d_SFO_2, time = "time")
-d_SFO_3 <- mkinpredict(m_SFO,
-  c(k_parent = 0.02),
-  c(parent = 103), sampling_times)
-d_SFO_3_long <- mkin_wide_to_long(d_SFO_3, time = "time")
-
-d1 <- add_err(d_SFO_1, function(value) 3, n = 1)
-d2 <- add_err(d_SFO_2, function(value) 2, n = 1)
-d3 <- add_err(d_SFO_3, function(value) 4, n = 1)
-ds <- c(d1 = d1, d2 = d2, d3 = d3)
-
-f <- mmkin("SFO", ds, cores = 1, quiet = TRUE)
-mean_dp <- mean_degparms(f)
-grouped_data <- nlme_data(f)
-nlme_f <- nlme_function(f)
-# These assignments are necessary for these objects to be
-# visible to nlme and augPred when evaluation is done by
-# pkgdown to generate the html docs.
-assign("nlme_f", nlme_f, globalenv())
-assign("grouped_data", grouped_data, globalenv())
-
-library(nlme)
-m_nlme <- nlme(value ~ nlme_f(name, time, parent_0, log_k_parent_sink),
-  data = grouped_data,
-  fixed = parent_0 + log_k_parent_sink ~ 1,
-  random = pdDiag(parent_0 + log_k_parent_sink ~ 1),
-  start = mean_dp)
-summary(m_nlme)
-#> Nonlinear mixed-effects model fit by maximum likelihood
-#>   Model: value ~ nlme_f(name, time, parent_0, log_k_parent_sink) 
-#>   Data: grouped_data 
-#>        AIC      BIC    logLik
-#>   266.6428 275.8935 -128.3214
-#> 
-#> Random effects:
-#>  Formula: list(parent_0 ~ 1, log_k_parent_sink ~ 1)
-#>  Level: ds
-#>  Structure: Diagonal
-#>             parent_0 log_k_parent_sink Residual
-#> StdDev: 0.0004253489         0.7058039 3.065183
-#> 
-#> Fixed effects:  parent_0 + log_k_parent_sink ~ 1 
-#>                       Value Std.Error DF   t-value p-value
-#> parent_0          101.18323 0.7900461 43 128.07256       0
-#> log_k_parent_sink  -3.08708 0.4171755 43  -7.39995       0
-#>  Correlation: 
-#>                   prnt_0
-#> log_k_parent_sink 0.031 
-#> 
-#> Standardized Within-Group Residuals:
-#>         Min          Q1         Med          Q3         Max 
-#> -2.38427071 -0.52059848  0.03593021  0.39987268  2.73188969 
-#> 
-#> Number of Observations: 47
-#> Number of Groups: 3 
-plot(augPred(m_nlme, level = 0:1), layout = c(3, 1))
-
-# augPred does not work on fits with more than one state
-# variable
-#
-# The procedure is greatly simplified by the nlme.mmkin function
-f_nlme <- nlme(f)
-plot(f_nlme)
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/nlme.mmkin-1.png b/docs/dev/reference/nlme.mmkin-1.png deleted file mode 100644 index 818c23a2..00000000 Binary files a/docs/dev/reference/nlme.mmkin-1.png and /dev/null differ diff --git a/docs/dev/reference/nlme.mmkin-2.png b/docs/dev/reference/nlme.mmkin-2.png deleted file mode 100644 index 779adbdb..00000000 Binary files a/docs/dev/reference/nlme.mmkin-2.png and /dev/null differ diff --git a/docs/dev/reference/nlme.mmkin-3.png b/docs/dev/reference/nlme.mmkin-3.png deleted file mode 100644 index b3785a78..00000000 Binary files a/docs/dev/reference/nlme.mmkin-3.png and /dev/null differ diff --git a/docs/dev/reference/nlme.mmkin.html b/docs/dev/reference/nlme.mmkin.html deleted file mode 100644 index 76d667b9..00000000 --- a/docs/dev/reference/nlme.mmkin.html +++ /dev/null @@ -1,464 +0,0 @@ - -Create an nlme model for an mmkin row object — nlme.mmkin • mkin - - -
-
- - - -
-
-
-

Create an nlme model for an mmkin row object

- Source: R/nlme.mmkin.R - -
- -
-

This functions sets up a nonlinear mixed effects model for an mmkin row -object. An mmkin row object is essentially a list of mkinfit objects that -have been obtained by fitting the same model to a list of datasets.

-
- -
- 
# S3 method for mmkin
-nlme(
-  model,
-  data = "auto",
-  fixed = lapply(as.list(names(mean_degparms(model))), function(el) eval(parse(text =
-    paste(el, 1, sep = "~")))),
-  random = pdDiag(fixed),
-  groups,
-  start = mean_degparms(model, random = TRUE, test_log_parms = TRUE),
-  correlation = NULL,
-  weights = NULL,
-  subset,
-  method = c("ML", "REML"),
-  na.action = na.fail,
-  naPattern,
-  control = list(),
-  verbose = FALSE
-)
-
-# S3 method for nlme.mmkin
-print(x, digits = max(3, getOption("digits") - 3), ...)
-
-# S3 method for nlme.mmkin
-update(object, ...)
-
- -
-

Arguments

-
model
-

An mmkin row object.

- - -
data
-

Ignored, data are taken from the mmkin model

- - -
fixed
-

Ignored, all degradation parameters fitted in the -mmkin model are used as fixed parameters

- - -
random
-

If not specified, no correlations between random effects are -set up for the optimised degradation model parameters. This is -achieved by using the nlme::pdDiag method.

- - -
groups
-

See the documentation of nlme

- - -
start
-

If not specified, mean values of the fitted degradation -parameters taken from the mmkin object are used

- - -
correlation
-

See the documentation of nlme

- - -
weights
-

passed to nlme

- - -
subset
-

passed to nlme

- - -
method
-

passed to nlme

- - -
na.action
-

passed to nlme

- - -
naPattern
-

passed to nlme

- - -
control
-

passed to nlme

- - -
verbose
-

passed to nlme

- - -
x
-

An nlme.mmkin object to print

- - -
digits
-

Number of digits to use for printing

- - -
...
-

Update specifications passed to update.nlme

- - -
object
-

An nlme.mmkin object to update

- -
-
-

Value

- - -

Upon success, a fitted 'nlme.mmkin' object, which is an nlme object -with additional elements. It also inherits from 'mixed.mmkin'.

-
-
-

Details

-

Note that the convergence of the nlme algorithms depends on the quality -of the data. In degradation kinetics, we often only have few datasets -(e.g. data for few soils) and complicated degradation models, which may -make it impossible to obtain convergence with nlme.

-
-
-

Note

-

As the object inherits from nlme::nlme, there is a wealth of -methods that will automatically work on 'nlme.mmkin' objects, such as -nlme::intervals(), nlme::anova.lme() and nlme::coef.lme().

-
- - -
-

Examples

- 
ds <- lapply(experimental_data_for_UBA_2019[6:10],
- function(x) subset(x$data[c("name", "time", "value")], name == "parent"))
-
-# \dontrun{
-  f <- mmkin(c("SFO", "DFOP"), ds, quiet = TRUE, cores = 1)
-  library(nlme)
-  f_nlme_sfo <- nlme(f["SFO", ])
-  f_nlme_dfop <- nlme(f["DFOP", ])
-  anova(f_nlme_sfo, f_nlme_dfop)
-#>             Model df      AIC      BIC    logLik   Test  L.Ratio p-value
-#> f_nlme_sfo      1  5 625.0539 637.5529 -307.5269                        
-#> f_nlme_dfop     2  9 495.1270 517.6253 -238.5635 1 vs 2 137.9268  <.0001
-  print(f_nlme_dfop)
-#> Kinetic nonlinear mixed-effects model fit by maximum likelihood
-#> 
-#> Structural model:
-#> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
-#>            time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
-#>            * parent
-#> 
-#> Data:
-#> 90 observations of 1 variable(s) grouped in 5 datasets
-#> 
-#> Log-likelihood: -238.6
-#> 
-#> Fixed effects:
-#>  list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) 
-#> parent_0   log_k1   log_k2 g_qlogis 
-#>  94.1702  -1.8002  -4.1474   0.0324 
-#> 
-#> Random effects:
-#>  Formula: list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1)
-#>  Level: ds
-#>  Structure: Diagonal
-#>         parent_0 log_k1 log_k2 g_qlogis Residual
-#> StdDev:    2.488 0.8447   1.33   0.4652    2.321
-#> 
-  plot(f_nlme_dfop)
-
-  endpoints(f_nlme_dfop)
-#> $distimes
-#>            DT50     DT90 DT50back  DT50_k1  DT50_k2
-#> parent 10.79857 100.7937 30.34192 4.193936 43.85441
-#> 
-
-  ds_2 <- lapply(experimental_data_for_UBA_2019[6:10],
-   function(x) x$data[c("name", "time", "value")])
-  m_sfo_sfo <- mkinmod(parent = mkinsub("SFO", "A1"),
-    A1 = mkinsub("SFO"), use_of_ff = "min", quiet = TRUE)
-  m_sfo_sfo_ff <- mkinmod(parent = mkinsub("SFO", "A1"),
-    A1 = mkinsub("SFO"), use_of_ff = "max", quiet = TRUE)
-  m_dfop_sfo <- mkinmod(parent = mkinsub("DFOP", "A1"),
-    A1 = mkinsub("SFO"), quiet = TRUE)
-
-  f_2 <- mmkin(list("SFO-SFO" = m_sfo_sfo,
-   "SFO-SFO-ff" = m_sfo_sfo_ff,
-   "DFOP-SFO" = m_dfop_sfo),
-    ds_2, quiet = TRUE)
-
-  f_nlme_sfo_sfo <- nlme(f_2["SFO-SFO", ])
-  plot(f_nlme_sfo_sfo)
-
-
-  # With formation fractions this does not coverge with defaults
-  # f_nlme_sfo_sfo_ff <- nlme(f_2["SFO-SFO-ff", ])
-  #plot(f_nlme_sfo_sfo_ff)
-
-  # For the following, we need to increase pnlsMaxIter and the tolerance
-  # to get convergence
-  f_nlme_dfop_sfo <- nlme(f_2["DFOP-SFO", ],
-    control = list(pnlsMaxIter = 120, tolerance = 5e-4))
-
-  plot(f_nlme_dfop_sfo)
-
-
-  anova(f_nlme_dfop_sfo, f_nlme_sfo_sfo)
-#>                 Model df       AIC       BIC    logLik   Test  L.Ratio p-value
-#> f_nlme_dfop_sfo     1 13  843.8547  884.6201 -408.9274                        
-#> f_nlme_sfo_sfo      2  9 1085.1821 1113.4043 -533.5910 1 vs 2 249.3274  <.0001
-
-  endpoints(f_nlme_sfo_sfo)
-#> $ff
-#> parent_sink   parent_A1     A1_sink 
-#>   0.5912432   0.4087568   1.0000000 
-#> 
-#> $distimes
-#>            DT50     DT90
-#> parent 19.13518  63.5657
-#> A1     66.02155 219.3189
-#> 
-  endpoints(f_nlme_dfop_sfo)
-#> $ff
-#>   parent_A1 parent_sink 
-#>   0.2768575   0.7231425 
-#> 
-#> $distimes
-#>             DT50     DT90 DT50back  DT50_k1  DT50_k2
-#> parent  11.07091 104.6320 31.49737 4.462384 46.20825
-#> A1     162.30507 539.1658       NA       NA       NA
-#> 
-
-  if (length(findFunction("varConstProp")) > 0) { # tc error model for nlme available
-    # Attempts to fit metabolite kinetics with the tc error model are possible,
-    # but need tweeking of control values and sometimes do not converge
-
-    f_tc <- mmkin(c("SFO", "DFOP"), ds, quiet = TRUE, error_model = "tc")
-    f_nlme_sfo_tc <- nlme(f_tc["SFO", ])
-    f_nlme_dfop_tc <- nlme(f_tc["DFOP", ])
-    AIC(f_nlme_sfo, f_nlme_sfo_tc, f_nlme_dfop, f_nlme_dfop_tc)
-    print(f_nlme_dfop_tc)
-  }
-#> Kinetic nonlinear mixed-effects model fit by maximum likelihood
-#> 
-#> Structural model:
-#> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
-#>            time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
-#>            * parent
-#> 
-#> Data:
-#> 90 observations of 1 variable(s) grouped in 5 datasets
-#> 
-#> Log-likelihood: -238.4
-#> 
-#> Fixed effects:
-#>  list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) 
-#> parent_0   log_k1   log_k2 g_qlogis 
-#> 94.04773 -1.82340 -4.16716  0.05686 
-#> 
-#> Random effects:
-#>  Formula: list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1)
-#>  Level: ds
-#>  Structure: Diagonal
-#>         parent_0 log_k1 log_k2 g_qlogis Residual
-#> StdDev:    2.474   0.85  1.337   0.4659        1
-#> 
-#> Variance function:
-#>  Structure: Constant plus proportion of variance covariate
-#>  Formula: ~fitted(.) 
-#>  Parameter estimates:
-#>      const       prop 
-#> 2.23223593 0.01262367 
-
-  f_2_obs <- update(f_2, error_model = "obs")
-  f_nlme_sfo_sfo_obs <- nlme(f_2_obs["SFO-SFO", ])
-  print(f_nlme_sfo_sfo_obs)
-#> Kinetic nonlinear mixed-effects model fit by maximum likelihood
-#> 
-#> Structural model:
-#> d_parent/dt = - k_parent_sink * parent - k_parent_A1 * parent
-#> d_A1/dt = + k_parent_A1 * parent - k_A1_sink * A1
-#> 
-#> Data:
-#> 170 observations of 2 variable(s) grouped in 5 datasets
-#> 
-#> Log-likelihood: -473
-#> 
-#> Fixed effects:
-#>  list(parent_0 ~ 1, log_k_parent_sink ~ 1, log_k_parent_A1 ~ 1,      log_k_A1_sink ~ 1) 
-#>          parent_0 log_k_parent_sink   log_k_parent_A1     log_k_A1_sink 
-#>            87.976            -3.670            -4.164            -4.645 
-#> 
-#> Random effects:
-#>  Formula: list(parent_0 ~ 1, log_k_parent_sink ~ 1, log_k_parent_A1 ~ 1,      log_k_A1_sink ~ 1)
-#>  Level: ds
-#>  Structure: Diagonal
-#>         parent_0 log_k_parent_sink log_k_parent_A1 log_k_A1_sink Residual
-#> StdDev:    3.992             1.777           1.055        0.4821    6.483
-#> 
-#> Variance function:
-#>  Structure: Different standard deviations per stratum
-#>  Formula: ~1 | name 
-#>  Parameter estimates:
-#>    parent        A1 
-#> 1.0000000 0.2049994 
-  f_nlme_dfop_sfo_obs <- nlme(f_2_obs["DFOP-SFO", ],
-    control = list(pnlsMaxIter = 120, tolerance = 5e-4))
-
-  f_2_tc <- update(f_2, error_model = "tc")
-  # f_nlme_sfo_sfo_tc <- nlme(f_2_tc["SFO-SFO", ]) # No convergence with 50 iterations
-  # f_nlme_dfop_sfo_tc <- nlme(f_2_tc["DFOP-SFO", ],
-  #  control = list(pnlsMaxIter = 120, tolerance = 5e-4)) # Error in X[, fmap[[nm]]] <- gradnm
-
-  anova(f_nlme_dfop_sfo, f_nlme_dfop_sfo_obs)
-#>                     Model df      AIC      BIC    logLik   Test  L.Ratio
-#> f_nlme_dfop_sfo         1 13 843.8547 884.6201 -408.9274                
-#> f_nlme_dfop_sfo_obs     2 14 817.5338 861.4350 -394.7669 1 vs 2 28.32093
-#>                     p-value
-#> f_nlme_dfop_sfo            
-#> f_nlme_dfop_sfo_obs  <.0001
-
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/nlmixr.mmkin-1.png b/docs/dev/reference/nlmixr.mmkin-1.png deleted file mode 100644 index 42a266e5..00000000 Binary files a/docs/dev/reference/nlmixr.mmkin-1.png and /dev/null differ diff --git a/docs/dev/reference/nlmixr.mmkin-2.png b/docs/dev/reference/nlmixr.mmkin-2.png deleted file mode 100644 index 0c440fa8..00000000 Binary files a/docs/dev/reference/nlmixr.mmkin-2.png and /dev/null differ diff --git a/docs/dev/reference/nlmixr.mmkin.html b/docs/dev/reference/nlmixr.mmkin.html deleted file mode 100644 index 82cef25d..00000000 --- a/docs/dev/reference/nlmixr.mmkin.html +++ /dev/null @@ -1,13271 +0,0 @@ - -Fit nonlinear mixed models using nlmixr — nlmixr.mmkin • mkin - - -
-
- - - -
-
-
-

Fit nonlinear mixed models using nlmixr

- Source: R/nlmixr.R - -
- -
-

This function uses nlmixr::nlmixr() as a backend for fitting nonlinear mixed -effects models created from mmkin row objects using the Stochastic Approximation -Expectation Maximisation algorithm (SAEM) or First Order Conditional -Estimation with Interaction (FOCEI).

-
- -
- 
# S3 method for mmkin
-nlmixr(
-  object,
-  data = NULL,
-  est = NULL,
-  control = list(),
-  table = tableControl(),
-  error_model = object[[1]]$err_mod,
-  test_log_parms = TRUE,
-  conf.level = 0.6,
-  degparms_start = "auto",
-  eta_start = "auto",
-  ...,
-  save = NULL,
-  envir = parent.frame()
-)
-
-# S3 method for nlmixr.mmkin
-print(x, digits = max(3, getOption("digits") - 3), ...)
-
-nlmixr_model(
-  object,
-  est = c("saem", "focei"),
-  degparms_start = "auto",
-  eta_start = "auto",
-  test_log_parms = TRUE,
-  conf.level = 0.6,
-  error_model = object[[1]]$err_mod,
-  add_attributes = FALSE
-)
-
-nlmixr_data(object, ...)
-
- -
-

Arguments

-
object
-

An mmkin row object containing several fits of the same -mkinmod model to different datasets

-
data
-

Not used, as the data are extracted from the mmkin row object

-
est
-

Estimation method passed to nlmixr::nlmixr

-
control
-

Passed to nlmixr::nlmixr

-
table
-

Passed to nlmixr::nlmixr

-
error_model
-

Optional argument to override the error model which is -being set based on the error model used in the mmkin row object.

-
test_log_parms
-

If TRUE, an attempt is made to use more robust starting -values for population parameters fitted as log parameters in mkin (like -rate constants) by only considering rate constants that pass the t-test -when calculating mean degradation parameters using mean_degparms.

-
conf.level
-

Possibility to adjust the required confidence level -for parameter that are tested if requested by 'test_log_parms'.

-
degparms_start
-

Parameter values given as a named numeric vector will -be used to override the starting values obtained from the 'mmkin' object.

-
eta_start
-

Standard deviations on the transformed scale given as a -named numeric vector will be used to override the starting values obtained -from the 'mmkin' object.

-
...
-

Passed to nlmixr_model

-
save
-

Passed to nlmixr::nlmixr

-
envir
-

Passed to nlmixr::nlmixr

-
x
-

An nlmixr.mmkin object to print

-
digits
-

Number of digits to use for printing

-
add_attributes
-

Should the starting values used for degradation model -parameters and their distribution and for the error model parameters -be returned as attributes?

-
-
-

Value

-

An S3 object of class 'nlmixr.mmkin', containing the fitted -nlmixr::nlmixr object as a list component named 'nm'. The -object also inherits from 'mixed.mmkin'. -An function defining a model suitable for fitting with nlmixr::nlmixr. -An dataframe suitable for use with nlmixr::nlmixr

-
-
-

Details

-

An mmkin row object is essentially a list of mkinfit objects that have been -obtained by fitting the same model to a list of datasets using mkinfit.

-
- - -
-

Examples

- 
# \dontrun{
-ds <- lapply(experimental_data_for_UBA_2019[6:10],
- function(x) subset(x$data[c("name", "time", "value")]))
-names(ds) <- paste("Dataset", 6:10)
-
-f_mmkin_parent <- mmkin(c("SFO", "FOMC", "DFOP", "HS"), ds, quiet = TRUE, cores = 1)
-f_mmkin_parent_tc <- mmkin(c("SFO", "FOMC", "DFOP"), ds, error_model = "tc",
-  cores = 1, quiet = TRUE)
-
-library(nlmixr)
-#> 
-#> Attaching package: ‘nlmixr’
-#> The following object is masked from ‘package:mkin’:
-#> 
-#>     saem
-f_nlmixr_sfo_saem <- nlmixr(f_mmkin_parent["SFO", ], est = "saem",
-  control = saemControl(print = 0))
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#>  
-#> → generate SAEM model
-#> ✔ done
-#> RxODE 1.1.4 using 8 threads (see ?getRxThreads)
-#>   no cache: create with `rxCreateCache()`
-#> Calculating covariance matrix
-#> 
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> Calculating residuals/tables
-#> done
-f_nlmixr_sfo_focei <- nlmixr(f_mmkin_parent["SFO", ], est = "focei",
-  control = foceiControl(print = 0))
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-
-f_nlmixr_fomc_saem <- nlmixr(f_mmkin_parent["FOMC", ], est = "saem",
-  control = saemControl(print = 0))
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#>  
-#> → generate SAEM model
-#> ✔ done
-#> Calculating covariance matrix
-#> 
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> Calculating residuals/tables
-#> done
-f_nlmixr_fomc_focei <- nlmixr(f_mmkin_parent["FOMC", ], est = "focei",
-  control = foceiControl(print = 0))
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-
-f_nlmixr_dfop_saem <- nlmixr(f_mmkin_parent["DFOP", ], est = "saem",
-  control = saemControl(print = 0))
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#>  
-#> → generate SAEM model
-#> ✔ done
-#> Calculating covariance matrix
-#> 
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> Calculating residuals/tables
-#> done
-f_nlmixr_dfop_focei <- nlmixr(f_mmkin_parent["DFOP", ], est = "focei",
-  control = foceiControl(print = 0))
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-
-f_nlmixr_hs_saem <- nlmixr(f_mmkin_parent["HS", ], est = "saem",
-  control = saemControl(print = 0))
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#>  
-#> → generate SAEM model
-#> ✔ done
-#> Calculating covariance matrix
-#> 
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> Calculating residuals/tables
-#> done
-f_nlmixr_hs_focei <- nlmixr(f_mmkin_parent["HS", ], est = "focei",
-  control = foceiControl(print = 0))
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-
-f_nlmixr_fomc_saem_tc <- nlmixr(f_mmkin_parent_tc["FOMC", ], est = "saem",
-  control = saemControl(print = 0))
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#>  
-#> Calculating covariance matrix
-#> 
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> Calculating residuals/tables
-#> done
-f_nlmixr_fomc_focei_tc <- nlmixr(f_mmkin_parent_tc["FOMC", ], est = "focei",
-  control = foceiControl(print = 0))
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> done
-#> Calculating residuals/tables
-#> done
-
-AIC(
-  f_nlmixr_sfo_saem$nm, f_nlmixr_sfo_focei$nm,
-  f_nlmixr_fomc_saem$nm, f_nlmixr_fomc_focei$nm,
-  f_nlmixr_dfop_saem$nm, f_nlmixr_dfop_focei$nm,
-  f_nlmixr_hs_saem$nm, f_nlmixr_hs_focei$nm,
-  f_nlmixr_fomc_saem_tc$nm, f_nlmixr_fomc_focei_tc$nm)
-#> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)
-#> 
-#> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)
-#> 
-#> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)
-#> 
-#> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)
-#> 
-#> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)
-#> 
-#>                           df      AIC
-#> f_nlmixr_sfo_saem$nm       5 624.9492
-#> f_nlmixr_sfo_focei$nm      5 625.0695
-#> f_nlmixr_fomc_saem$nm      7 463.7577
-#> f_nlmixr_fomc_focei$nm     7 468.0861
-#> f_nlmixr_dfop_saem$nm      9 495.1980
-#> f_nlmixr_dfop_focei$nm     9 495.1072
-#> f_nlmixr_hs_saem$nm        9 531.0689
-#> f_nlmixr_hs_focei$nm       9 545.6728
-#> f_nlmixr_fomc_saem_tc$nm   8 462.1411
-#> f_nlmixr_fomc_focei_tc$nm  8 470.0745
-
-AIC(nlme(f_mmkin_parent["FOMC", ]))
-#> [1] 468.0781
-AIC(nlme(f_mmkin_parent["HS", ]))
-#> [1] 535.609
-
-# The FOCEI fit of FOMC with constant variance or the tc error model is best
-plot(f_nlmixr_fomc_saem_tc)
-
-
-sfo_sfo <- mkinmod(parent = mkinsub("SFO", "A1"),
-  A1 = mkinsub("SFO"), quiet = TRUE)
-fomc_sfo <- mkinmod(parent = mkinsub("FOMC", "A1"),
-  A1 = mkinsub("SFO"), quiet = TRUE)
-dfop_sfo <- mkinmod(parent = mkinsub("DFOP", "A1"),
-  A1 = mkinsub("SFO"), quiet = TRUE)
-
-f_mmkin_const <- mmkin(list(
-    "SFO-SFO" = sfo_sfo, "FOMC-SFO" = fomc_sfo, "DFOP-SFO" = dfop_sfo),
-  ds, quiet = TRUE, error_model = "const")
-f_mmkin_obs <- mmkin(list(
-    "SFO-SFO" = sfo_sfo, "FOMC-SFO" = fomc_sfo, "DFOP-SFO" = dfop_sfo),
-  ds, quiet = TRUE, error_model = "obs")
-f_mmkin_tc <- mmkin(list(
-    "SFO-SFO" = sfo_sfo, "FOMC-SFO" = fomc_sfo, "DFOP-SFO" = dfop_sfo),
-  ds, quiet = TRUE, error_model = "tc")
-
-nlmixr_model(f_mmkin_const["SFO-SFO", ])
-#> Constant variance for more than one variable is not supported for est = 'saem'
-#> Changing the error model to 'obs' (variance by observed variable)
-#> function () 
-#> {
-#>     ini({
-#>         parent_0 = 87
-#>         eta.parent_0 ~ 4.2
-#>         log_k_parent = -3.2
-#>         eta.log_k_parent ~ 1.5
-#>         log_k_A1 = -4.6
-#>         eta.log_k_A1 ~ 0.56
-#>         f_parent_qlogis = -0.33
-#>         eta.f_parent_qlogis ~ 1.1
-#>         sigma_parent = 4.3
-#>         sigma_A1 = 4.3
-#>     })
-#>     model({
-#>         parent_0_model = parent_0 + eta.parent_0
-#>         parent(0) = parent_0_model
-#>         k_parent = exp(log_k_parent + eta.log_k_parent)
-#>         k_A1 = exp(log_k_A1 + eta.log_k_A1)
-#>         f_parent_to_A1 = expit(f_parent_qlogis + eta.f_parent_qlogis)
-#>         d/dt(parent) = -k_parent * parent
-#>         d/dt(A1) = +f_parent_to_A1 * k_parent * parent - k_A1 * 
-#>             A1
-#>         parent ~ add(sigma_parent)
-#>         A1 ~ add(sigma_A1)
-#>     })
-#> }
-#> <environment: 0x55556c775068>
-
-# A single constant variance is currently only possible with est = 'focei' in nlmixr
-f_nlmixr_sfo_sfo_focei_const <- nlmixr(f_mmkin_const["SFO-SFO", ], est = "focei")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
-#> F: Forward difference gradient approximation
-#> C: Central difference gradient approximation
-#> M: Mixed forward and central difference gradient approximation
-#> Unscaled parameters for Omegas=chol(solve(omega));
-#> Diagonals are transformed, as specified by foceiControl(diagXform=)
-#> |-----+---------------+-----------+-----------+-----------+-----------|
-#> |    #| Objective Fun |  parent_0 |log_k_parent |  log_k_A1 |f_parent_qlogis |
-#> |.....................|     sigma |        o1 |        o2 |        o3 |
-#> |.....................|        o4 |...........|...........|...........|
-#> |    1|     756.61847 |     1.000 |   -0.9694 |    -1.000 |   -0.9068 |
-#> |.....................|   -0.8057 |   -0.8843 |   -0.8798 |   -0.8743 |
-#> |.....................|   -0.8782 |...........|...........|...........|
-#> |    U|     756.61847 |     87.00 |    -3.200 |    -4.600 |   -0.3300 |
-#> |.....................|     4.300 |    0.6985 |    0.9036 |     1.156 |
-#> |.....................|    0.9765 |...........|...........|...........|
-#> |    X|     756.61847 |     87.00 |   0.04076 |   0.01005 |    0.4182 |
-#> |.....................|     4.300 |    0.6985 |    0.9036 |     1.156 |
-#> |.....................|    0.9765 |...........|...........|...........|
-#> |    G|    Gill Diff. |     104.1 |   0.02915 |    0.3320 |    0.4427 |
-#> |.....................|    -29.46 |     6.499 |     3.260 |    -8.158 |
-#> |.....................|    -5.501 |...........|...........|...........|
-#> |    2|     4014.8405 |   0.04387 |   -0.9697 |    -1.003 |   -0.9108 |
-#> |.....................|   -0.5352 |   -0.9440 |   -0.9098 |   -0.7994 |
-#> |.....................|   -0.8277 |...........|...........|...........|
-#> |    U|     4014.8405 |     3.817 |    -3.200 |    -4.603 |   -0.3313 |
-#> |.....................|     4.882 |    0.6569 |    0.8766 |     1.243 |
-#> |.....................|     1.026 |...........|...........|...........|
-#> |    X|     4014.8405 |     3.817 |   0.04075 |   0.01002 |    0.4179 |
-#> |.....................|     4.882 |    0.6569 |    0.8766 |     1.243 |
-#> |.....................|     1.026 |...........|...........|...........|
-#> |    3|     784.09766 |    0.9044 |   -0.9695 |    -1.000 |   -0.9072 |
-#> |.....................|   -0.7786 |   -0.8903 |   -0.8828 |   -0.8668 |
-#> |.....................|   -0.8732 |...........|...........|...........|
-#> |    U|     784.09766 |     78.68 |    -3.200 |    -4.600 |   -0.3301 |
-#> |.....................|     4.358 |    0.6944 |    0.9009 |     1.165 |
-#> |.....................|    0.9814 |...........|...........|...........|
-#> |    X|     784.09766 |     78.68 |   0.04076 |   0.01005 |    0.4182 |
-#> |.....................|     4.358 |    0.6944 |    0.9009 |     1.165 |
-#> |.....................|    0.9814 |...........|...........|...........|
-#> |    4|     755.85897 |    0.9864 |   -0.9694 |    -1.000 |   -0.9068 |
-#> |.....................|   -0.8018 |   -0.8852 |   -0.8803 |   -0.8733 |
-#> |.....................|   -0.8775 |...........|...........|...........|
-#> |    U|     755.85897 |     85.82 |    -3.200 |    -4.600 |   -0.3300 |
-#> |.....................|     4.308 |    0.6979 |    0.9032 |     1.157 |
-#> |.....................|    0.9772 |...........|...........|...........|
-#> |    X|     755.85897 |     85.82 |   0.04076 |   0.01005 |    0.4182 |
-#> |.....................|     4.308 |    0.6979 |    0.9032 |     1.157 |
-#> |.....................|    0.9772 |...........|...........|...........|
-#> |    F| Forward Diff. |    -10.67 |    0.1182 |    0.2197 |    0.3686 |
-#> |.....................|    -28.82 |     3.860 |     3.200 |    -8.294 |
-#> |.....................|    -5.254 |...........|...........|...........|
-#> |    5|     755.50135 |    0.9911 |   -0.9695 |    -1.000 |   -0.9070 |
-#> |.....................|   -0.7893 |   -0.8868 |   -0.8816 |   -0.8697 |
-#> |.....................|   -0.8752 |...........|...........|...........|
-#> |    U|     755.50135 |     86.22 |    -3.200 |    -4.600 |   -0.3301 |
-#> |.....................|     4.335 |    0.6968 |    0.9020 |     1.161 |
-#> |.....................|    0.9794 |...........|...........|...........|
-#> |    X|     755.50135 |     86.22 |   0.04076 |   0.01005 |    0.4182 |
-#> |.....................|     4.335 |    0.6968 |    0.9020 |     1.161 |
-#> |.....................|    0.9794 |...........|...........|...........|
-#> |    6|     755.34910 |    0.9966 |   -0.9695 |    -1.000 |   -0.9072 |
-#> |.....................|   -0.7744 |   -0.8888 |   -0.8833 |   -0.8654 |
-#> |.....................|   -0.8725 |...........|...........|...........|
-#> |    U|      755.3491 |     86.70 |    -3.200 |    -4.600 |   -0.3301 |
-#> |.....................|     4.367 |    0.6954 |    0.9005 |     1.166 |
-#> |.....................|    0.9820 |...........|...........|...........|
-#> |    X|      755.3491 |     86.70 |   0.04076 |   0.01005 |    0.4182 |
-#> |.....................|     4.367 |    0.6954 |    0.9005 |     1.166 |
-#> |.....................|    0.9820 |...........|...........|...........|
-#> |    F| Forward Diff. |     73.92 |   0.04965 |    0.3063 |    0.4373 |
-#> |.....................|    -23.46 |     5.143 |     2.934 |    -7.746 |
-#> |.....................|    -5.165 |...........|...........|...........|
-#> |    7|     754.44379 |    0.9831 |   -0.9697 |    -1.001 |   -0.9076 |
-#> |.....................|   -0.7489 |   -0.8930 |   -0.8865 |   -0.8566 |
-#> |.....................|   -0.8669 |...........|...........|...........|
-#> |    U|     754.44379 |     85.53 |    -3.200 |    -4.601 |   -0.3303 |
-#> |.....................|     4.422 |    0.6925 |    0.8975 |     1.176 |
-#> |.....................|    0.9875 |...........|...........|...........|
-#> |    X|     754.44379 |     85.53 |   0.04075 |   0.01005 |    0.4182 |
-#> |.....................|     4.422 |    0.6925 |    0.8975 |     1.176 |
-#> |.....................|    0.9875 |...........|...........|...........|
-#> |    F| Forward Diff. |    -36.39 |    0.1354 |    0.1953 |    0.3724 |
-#> |.....................|    -19.20 |     3.020 |     2.621 |    -7.506 |
-#> |.....................|    -4.671 |...........|...........|...........|
-#> |    8|     753.82350 |    0.9908 |   -0.9699 |    -1.001 |   -0.9085 |
-#> |.....................|   -0.7249 |   -0.8992 |   -0.8910 |   -0.8427 |
-#> |.....................|   -0.8580 |...........|...........|...........|
-#> |    U|      753.8235 |     86.20 |    -3.200 |    -4.601 |   -0.3306 |
-#> |.....................|     4.474 |    0.6881 |    0.8935 |     1.193 |
-#> |.....................|    0.9962 |...........|...........|...........|
-#> |    X|      753.8235 |     86.20 |   0.04074 |   0.01004 |    0.4181 |
-#> |.....................|     4.474 |    0.6881 |    0.8935 |     1.193 |
-#> |.....................|    0.9962 |...........|...........|...........|
-#> |    F| Forward Diff. |     25.33 |   0.08213 |    0.2542 |    0.4339 |
-#> |.....................|    -14.89 |     3.322 |     2.230 |    -6.934 |
-#> |.....................|    -4.324 |...........|...........|...........|
-#> |    9|     753.42397 |    0.9836 |   -0.9702 |    -1.002 |   -0.9101 |
-#> |.....................|   -0.7094 |   -0.9058 |   -0.8962 |   -0.8215 |
-#> |.....................|   -0.8457 |...........|...........|...........|
-#> |    U|     753.42397 |     85.57 |    -3.201 |    -4.602 |   -0.3311 |
-#> |.....................|     4.507 |    0.6835 |    0.8888 |     1.217 |
-#> |.....................|     1.008 |...........|...........|...........|
-#> |    X|     753.42397 |     85.57 |   0.04073 |   0.01003 |    0.4180 |
-#> |.....................|     4.507 |    0.6835 |    0.8888 |     1.217 |
-#> |.....................|     1.008 |...........|...........|...........|
-#> |    F| Forward Diff. |    -31.38 |    0.1220 |    0.1752 |    0.4111 |
-#> |.....................|    -12.58 |     2.402 |     1.769 |    -6.044 |
-#> |.....................|    -3.541 |...........|...........|...........|
-#> |   10|     753.10125 |    0.9902 |   -0.9707 |    -1.003 |   -0.9128 |
-#> |.....................|   -0.7033 |   -0.9147 |   -0.8999 |   -0.7966 |
-#> |.....................|   -0.8328 |...........|...........|...........|
-#> |    U|     753.10125 |     86.15 |    -3.201 |    -4.603 |   -0.3320 |
-#> |.....................|     4.520 |    0.6773 |    0.8855 |     1.246 |
-#> |.....................|     1.021 |...........|...........|...........|
-#> |    X|     753.10125 |     86.15 |   0.04071 |   0.01002 |    0.4178 |
-#> |.....................|     4.520 |    0.6773 |    0.8855 |     1.246 |
-#> |.....................|     1.021 |...........|...........|...........|
-#> |    F| Forward Diff. |     18.19 |   0.07644 |    0.2005 |    0.4693 |
-#> |.....................|    -11.34 |     2.660 |     1.470 |    -4.866 |
-#> |.....................|    -2.908 |...........|...........|...........|
-#> |   11|     752.83558 |    0.9856 |   -0.9716 |    -1.004 |   -0.9194 |
-#> |.....................|   -0.6931 |   -0.9294 |   -0.8999 |   -0.7740 |
-#> |.....................|   -0.8246 |...........|...........|...........|
-#> |    U|     752.83558 |     85.75 |    -3.202 |    -4.604 |   -0.3342 |
-#> |.....................|     4.542 |    0.6671 |    0.8855 |     1.272 |
-#> |.....................|     1.029 |...........|...........|...........|
-#> |    X|     752.83558 |     85.75 |   0.04067 |   0.01001 |    0.4172 |
-#> |.....................|     4.542 |    0.6671 |    0.8855 |     1.272 |
-#> |.....................|     1.029 |...........|...........|...........|
-#> |    F| Forward Diff. |    -17.42 |   0.09700 |    0.1175 |    0.4453 |
-#> |.....................|    -9.793 |     1.829 |     1.489 |    -3.997 |
-#> |.....................|    -2.337 |...........|...........|...........|
-#> |   12|     752.64046 |    0.9898 |   -0.9731 |    -1.005 |   -0.9331 |
-#> |.....................|   -0.6718 |   -0.9413 |   -0.9101 |   -0.7759 |
-#> |.....................|   -0.8318 |...........|...........|...........|
-#> |    U|     752.64046 |     86.12 |    -3.204 |    -4.605 |   -0.3387 |
-#> |.....................|     4.588 |    0.6587 |    0.8763 |     1.270 |
-#> |.....................|     1.022 |...........|...........|...........|
-#> |    X|     752.64046 |     86.12 |   0.04061 |   0.01000 |    0.4161 |
-#> |.....................|     4.588 |    0.6587 |    0.8763 |     1.270 |
-#> |.....................|     1.022 |...........|...........|...........|
-#> |    F| Forward Diff. |     12.96 |   0.06018 |    0.1556 |    0.4415 |
-#> |.....................|    -6.445 |     1.822 |    0.6282 |    -4.092 |
-#> |.....................|    -2.761 |...........|...........|...........|
-#> |   13|     752.52461 |    0.9874 |   -0.9741 |    -1.006 |   -0.9430 |
-#> |.....................|   -0.6755 |   -0.9483 |   -0.9069 |   -0.7553 |
-#> |.....................|   -0.8127 |...........|...........|...........|
-#> |    U|     752.52461 |     85.90 |    -3.205 |    -4.606 |   -0.3420 |
-#> |.....................|     4.580 |    0.6538 |    0.8792 |     1.294 |
-#> |.....................|     1.040 |...........|...........|...........|
-#> |    X|     752.52461 |     85.90 |   0.04057 |  0.009996 |    0.4153 |
-#> |.....................|     4.580 |    0.6538 |    0.8792 |     1.294 |
-#> |.....................|     1.040 |...........|...........|...........|
-#> |    F| Forward Diff. |    -5.319 |   0.06758 |    0.1323 |    0.4528 |
-#> |.....................|    -7.018 |     1.348 |    0.9128 |    -3.312 |
-#> |.....................|    -1.706 |...........|...........|...........|
-#> |   14|     752.47650 |    0.9920 |   -0.9750 |    -1.008 |   -0.9578 |
-#> |.....................|   -0.6735 |   -0.9481 |   -0.9014 |   -0.7293 |
-#> |.....................|   -0.8100 |...........|...........|...........|
-#> |    U|      752.4765 |     86.30 |    -3.206 |    -4.608 |   -0.3468 |
-#> |.....................|     4.584 |    0.6539 |    0.8841 |     1.324 |
-#> |.....................|     1.043 |...........|...........|...........|
-#> |    X|      752.4765 |     86.30 |   0.04054 |  0.009974 |    0.4142 |
-#> |.....................|     4.584 |    0.6539 |    0.8841 |     1.324 |
-#> |.....................|     1.043 |...........|...........|...........|
-#> |    F| Forward Diff. |     26.38 |   0.03719 |   0.08701 |    0.4621 |
-#> |.....................|    -6.642 |     1.808 |     1.401 |    -2.463 |
-#> |.....................|    -1.595 |...........|...........|...........|
-#> |   15|     752.37074 |    0.9880 |   -0.9759 |    -1.009 |   -0.9778 |
-#> |.....................|   -0.6665 |   -0.9465 |   -0.9156 |   -0.7192 |
-#> |.....................|   -0.8239 |...........|...........|...........|
-#> |    U|     752.37074 |     85.96 |    -3.206 |    -4.609 |   -0.3534 |
-#> |.....................|     4.599 |    0.6551 |    0.8713 |     1.335 |
-#> |.....................|     1.030 |...........|...........|...........|
-#> |    X|     752.37074 |     85.96 |   0.04050 |  0.009963 |    0.4125 |
-#> |.....................|     4.599 |    0.6551 |    0.8713 |     1.335 |
-#> |.....................|     1.030 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.8866 |   0.05090 |  -0.01541 |    0.3812 |
-#> |.....................|    -5.712 |     1.436 |    0.1646 |    -2.191 |
-#> |.....................|    -2.247 |...........|...........|...........|
-#> |   16|     752.26949 |    0.9921 |   -0.9761 |    -1.009 |   -0.9796 |
-#> |.....................|   -0.6402 |   -0.9531 |   -0.9164 |   -0.7091 |
-#> |.....................|   -0.8135 |...........|...........|...........|
-#> |    U|     752.26949 |     86.31 |    -3.207 |    -4.609 |   -0.3540 |
-#> |.....................|     4.656 |    0.6505 |    0.8706 |     1.347 |
-#> |.....................|     1.040 |...........|...........|...........|
-#> |    X|     752.26949 |     86.31 |   0.04049 |  0.009963 |    0.4124 |
-#> |.....................|     4.656 |    0.6505 |    0.8706 |     1.347 |
-#> |.....................|     1.040 |...........|...........|...........|
-#> |    F| Forward Diff. |     26.82 |   0.02710 |   0.03892 |    0.4267 |
-#> |.....................|    -2.005 |     1.500 |    0.1022 |    -1.862 |
-#> |.....................|    -1.773 |...........|...........|...........|
-#> |   17|     752.20271 |    0.9873 |   -0.9768 |    -1.006 |   -0.9927 |
-#> |.....................|   -0.6361 |   -0.9677 |   -0.9007 |   -0.7162 |
-#> |.....................|   -0.7982 |...........|...........|...........|
-#> |    U|     752.20271 |     85.89 |    -3.207 |    -4.606 |   -0.3584 |
-#> |.....................|     4.664 |    0.6403 |    0.8848 |     1.339 |
-#> |.....................|     1.055 |...........|...........|...........|
-#> |    X|     752.20271 |     85.89 |   0.04046 |  0.009992 |    0.4114 |
-#> |.....................|     4.664 |    0.6403 |    0.8848 |     1.339 |
-#> |.....................|     1.055 |...........|...........|...........|
-#> |    F| Forward Diff. |    -7.259 |   0.05081 |    0.1320 |    0.4166 |
-#> |.....................|    -1.497 |    0.4663 |     1.471 |    -1.984 |
-#> |.....................|   -0.9590 |...........|...........|...........|
-#> |   18|     752.16826 |    0.9883 |   -0.9778 |    -1.006 |    -1.005 |
-#> |.....................|   -0.6437 |   -0.9795 |   -0.9210 |   -0.7076 |
-#> |.....................|   -0.7873 |...........|...........|...........|
-#> |    U|     752.16826 |     85.98 |    -3.208 |    -4.606 |   -0.3626 |
-#> |.....................|     4.648 |    0.6320 |    0.8664 |     1.349 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.16826 |     85.98 |   0.04042 |  0.009989 |    0.4103 |
-#> |.....................|     4.648 |    0.6320 |    0.8664 |     1.349 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |    -1.732 |   0.03428 |    0.1666 |    0.4265 |
-#> |.....................|    -2.413 |    0.2526 |   -0.2557 |    -1.689 |
-#> |.....................|   -0.3553 |...........|...........|...........|
-#> |   19|     752.25223 |    0.9952 |   -0.9788 |    -1.010 |    -1.023 |
-#> |.....................|   -0.6370 |   -0.9826 |   -0.9156 |   -0.6853 |
-#> |.....................|   -0.7912 |...........|...........|...........|
-#> |    U|     752.25223 |     86.58 |    -3.209 |    -4.610 |   -0.3684 |
-#> |.....................|     4.663 |    0.6299 |    0.8713 |     1.374 |
-#> |.....................|     1.061 |...........|...........|...........|
-#> |    X|     752.25223 |     86.58 |   0.04038 |  0.009949 |    0.4089 |
-#> |.....................|     4.663 |    0.6299 |    0.8713 |     1.374 |
-#> |.....................|     1.061 |...........|...........|...........|
-#> |   20|     752.18605 |    0.9920 |   -0.9778 |    -1.007 |    -1.006 |
-#> |.....................|   -0.6387 |   -0.9801 |   -0.9204 |   -0.7040 |
-#> |.....................|   -0.7866 |...........|...........|...........|
-#> |    U|     752.18605 |     86.30 |    -3.208 |    -4.607 |   -0.3629 |
-#> |.....................|     4.659 |    0.6316 |    0.8669 |     1.353 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    X|     752.18605 |     86.30 |   0.04042 |  0.009985 |    0.4103 |
-#> |.....................|     4.659 |    0.6316 |    0.8669 |     1.353 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |   21|     752.16428 |    0.9894 |   -0.9778 |    -1.006 |    -1.006 |
-#> |.....................|   -0.6422 |   -0.9797 |   -0.9208 |   -0.7065 |
-#> |.....................|   -0.7871 |...........|...........|...........|
-#> |    U|     752.16428 |     86.08 |    -3.208 |    -4.606 |   -0.3627 |
-#> |.....................|     4.651 |    0.6319 |    0.8666 |     1.350 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.16428 |     86.08 |   0.04042 |  0.009988 |    0.4103 |
-#> |.....................|     4.651 |    0.6319 |    0.8666 |     1.350 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |     5.144 |   0.02886 |    0.1726 |    0.4333 |
-#> |.....................|    -2.192 |    0.3285 |   -0.2407 |    -1.661 |
-#> |.....................|   -0.3568 |...........|...........|...........|
-#> |   22|     752.15919 |    0.9884 |   -0.9779 |    -1.007 |    -1.007 |
-#> |.....................|   -0.6420 |   -0.9798 |   -0.9206 |   -0.7051 |
-#> |.....................|   -0.7874 |...........|...........|...........|
-#> |    U|     752.15919 |     85.99 |    -3.208 |    -4.607 |   -0.3630 |
-#> |.....................|     4.652 |    0.6319 |    0.8668 |     1.352 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.15919 |     85.99 |   0.04042 |  0.009985 |    0.4102 |
-#> |.....................|     4.652 |    0.6319 |    0.8668 |     1.352 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |    -1.486 |   0.03361 |    0.1549 |    0.4244 |
-#> |.....................|    -2.177 |    0.2364 |   -0.2213 |    -1.616 |
-#> |.....................|   -0.3570 |...........|...........|...........|
-#> |   23|     752.15545 |    0.9894 |   -0.9779 |    -1.007 |    -1.007 |
-#> |.....................|   -0.6405 |   -0.9799 |   -0.9204 |   -0.7040 |
-#> |.....................|   -0.7872 |...........|...........|...........|
-#> |    U|     752.15545 |     86.07 |    -3.208 |    -4.607 |   -0.3631 |
-#> |.....................|     4.655 |    0.6318 |    0.8669 |     1.353 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.15545 |     86.07 |   0.04042 |  0.009984 |    0.4102 |
-#> |.....................|     4.655 |    0.6318 |    0.8669 |     1.353 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |     4.936 |   0.02854 |    0.1600 |    0.4306 |
-#> |.....................|    -1.962 |    0.3065 |   -0.2063 |    -1.586 |
-#> |.....................|   -0.3570 |...........|...........|...........|
-#> |   24|     752.15077 |    0.9884 |   -0.9779 |    -1.007 |    -1.008 |
-#> |.....................|   -0.6403 |   -0.9800 |   -0.9202 |   -0.7026 |
-#> |.....................|   -0.7875 |...........|...........|...........|
-#> |    U|     752.15077 |     85.99 |    -3.209 |    -4.607 |   -0.3635 |
-#> |.....................|     4.656 |    0.6317 |    0.8672 |     1.355 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.15077 |     85.99 |   0.04042 |  0.009981 |    0.4101 |
-#> |.....................|     4.656 |    0.6317 |    0.8672 |     1.355 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |    -1.303 |   0.03292 |    0.1430 |    0.4220 |
-#> |.....................|    -1.955 |    0.2207 |   -0.1874 |    -1.542 |
-#> |.....................|   -0.3581 |...........|...........|...........|
-#> |   25|     752.14731 |    0.9893 |   -0.9780 |    -1.007 |    -1.009 |
-#> |.....................|   -0.6389 |   -0.9801 |   -0.9200 |   -0.7014 |
-#> |.....................|   -0.7873 |...........|...........|...........|
-#> |    U|     752.14731 |     86.07 |    -3.209 |    -4.607 |   -0.3637 |
-#> |.....................|     4.659 |    0.6316 |    0.8673 |     1.356 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.14731 |     86.07 |   0.04042 |  0.009980 |    0.4101 |
-#> |.....................|     4.659 |    0.6316 |    0.8673 |     1.356 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |     4.764 |   0.02806 |    0.1473 |    0.4277 |
-#> |.....................|    -1.749 |    0.2865 |   -0.1727 |    -1.510 |
-#> |.....................|   -0.3572 |...........|...........|...........|
-#> |   26|     752.14299 |    0.9884 |   -0.9780 |    -1.007 |    -1.010 |
-#> |.....................|   -0.6388 |   -0.9801 |   -0.9198 |   -0.7000 |
-#> |.....................|   -0.7876 |...........|...........|...........|
-#> |    U|     752.14299 |     85.99 |    -3.209 |    -4.607 |   -0.3641 |
-#> |.....................|     4.659 |    0.6316 |    0.8675 |     1.358 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.14299 |     85.99 |   0.04041 |  0.009978 |    0.4100 |
-#> |.....................|     4.659 |    0.6316 |    0.8675 |     1.358 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |    -1.130 |   0.03192 |    0.1311 |    0.4194 |
-#> |.....................|    -1.750 |    0.2064 |   -0.1542 |    -1.466 |
-#> |.....................|   -0.3587 |...........|...........|...........|
-#> |   27|     752.13982 |    0.9893 |   -0.9781 |    -1.008 |    -1.010 |
-#> |.....................|   -0.6374 |   -0.9803 |   -0.9196 |   -0.6987 |
-#> |.....................|   -0.7873 |...........|...........|...........|
-#> |    U|     752.13982 |     86.07 |    -3.209 |    -4.608 |   -0.3642 |
-#> |.....................|     4.662 |    0.6315 |    0.8676 |     1.359 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.13982 |     86.07 |   0.04041 |  0.009977 |    0.4099 |
-#> |.....................|     4.662 |    0.6315 |    0.8676 |     1.359 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |     4.635 |   0.02760 |    0.1350 |    0.4248 |
-#> |.....................|    -1.550 |    0.2683 |   -0.1407 |    -1.433 |
-#> |.....................|   -0.3557 |...........|...........|...........|
-#> |   28|     752.13580 |    0.9884 |   -0.9782 |    -1.008 |    -1.012 |
-#> |.....................|   -0.6373 |   -0.9803 |   -0.9194 |   -0.6973 |
-#> |.....................|   -0.7876 |...........|...........|...........|
-#> |    U|      752.1358 |     85.99 |    -3.209 |    -4.608 |   -0.3647 |
-#> |.....................|     4.662 |    0.6315 |    0.8678 |     1.361 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|      752.1358 |     85.99 |   0.04041 |  0.009975 |    0.4098 |
-#> |.....................|     4.662 |    0.6315 |    0.8678 |     1.361 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.9657 |   0.03147 |    0.1207 |    0.4166 |
-#> |.....................|    -1.557 |    0.1931 |   -0.1227 |    -1.391 |
-#> |.....................|   -0.3574 |...........|...........|...........|
-#> |   29|     752.13295 |    0.9893 |   -0.9782 |    -1.008 |    -1.012 |
-#> |.....................|   -0.6359 |   -0.9805 |   -0.9193 |   -0.6961 |
-#> |.....................|   -0.7873 |...........|...........|...........|
-#> |    U|     752.13295 |     86.07 |    -3.209 |    -4.608 |   -0.3648 |
-#> |.....................|     4.665 |    0.6314 |    0.8679 |     1.362 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.13295 |     86.07 |   0.04041 |  0.009973 |    0.4098 |
-#> |.....................|     4.665 |    0.6314 |    0.8679 |     1.362 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |     4.554 |   0.02702 |    0.1245 |    0.4220 |
-#> |.....................|    -1.357 |    0.2511 |   -0.1114 |    -1.356 |
-#> |.....................|   -0.3512 |...........|...........|...........|
-#> |   30|     752.12919 |    0.9885 |   -0.9783 |    -1.008 |    -1.014 |
-#> |.....................|   -0.6359 |   -0.9804 |   -0.9191 |   -0.6947 |
-#> |.....................|   -0.7876 |...........|...........|...........|
-#> |    U|     752.12919 |     86.00 |    -3.209 |    -4.608 |   -0.3653 |
-#> |.....................|     4.665 |    0.6314 |    0.8681 |     1.364 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.12919 |     86.00 |   0.04040 |  0.009972 |    0.4097 |
-#> |.....................|     4.665 |    0.6314 |    0.8681 |     1.364 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.8077 |   0.03076 |    0.1104 |    0.4140 |
-#> |.....................|    -1.370 |    0.1799 |  -0.09417 |    -1.307 |
-#> |.....................|   -0.3529 |...........|...........|...........|
-#> |   31|     752.12656 |    0.9893 |   -0.9783 |    -1.008 |    -1.014 |
-#> |.....................|   -0.6345 |   -0.9806 |   -0.9190 |   -0.6934 |
-#> |.....................|   -0.7872 |...........|...........|...........|
-#> |    U|     752.12656 |     86.07 |    -3.209 |    -4.608 |   -0.3654 |
-#> |.....................|     4.668 |    0.6313 |    0.8682 |     1.365 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.12656 |     86.07 |   0.04040 |  0.009970 |    0.4096 |
-#> |.....................|     4.668 |    0.6313 |    0.8682 |     1.365 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |     4.375 |   0.02651 |    0.1140 |    0.4191 |
-#> |.....................|    -1.173 |    0.2330 |  -0.08481 |    -1.281 |
-#> |.....................|   -0.3435 |...........|...........|...........|
-#> |   32|     752.12310 |    0.9885 |   -0.9784 |    -1.008 |    -1.016 |
-#> |.....................|   -0.6345 |   -0.9806 |   -0.9188 |   -0.6922 |
-#> |.....................|   -0.7875 |...........|...........|...........|
-#> |    U|      752.1231 |     86.00 |    -3.209 |    -4.608 |   -0.3659 |
-#> |.....................|     4.668 |    0.6313 |    0.8684 |     1.367 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|      752.1231 |     86.00 |   0.04040 |  0.009969 |    0.4095 |
-#> |.....................|     4.668 |    0.6313 |    0.8684 |     1.367 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.6515 |   0.02994 |    0.1012 |    0.4113 |
-#> |.....................|    -1.192 |    0.1669 |  -0.06829 |    -1.233 |
-#> |.....................|   -0.3455 |...........|...........|...........|
-#> |   33|     752.12055 |    0.9892 |   -0.9784 |    -1.008 |    -1.016 |
-#> |.....................|   -0.6332 |   -0.9808 |   -0.9187 |   -0.6908 |
-#> |.....................|   -0.7871 |...........|...........|...........|
-#> |    U|     752.12055 |     86.06 |    -3.209 |    -4.608 |   -0.3661 |
-#> |.....................|     4.671 |    0.6312 |    0.8685 |     1.368 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.12055 |     86.06 |   0.04040 |  0.009968 |    0.4095 |
-#> |.....................|     4.671 |    0.6312 |    0.8685 |     1.368 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |     3.998 |   0.02610 |    0.1041 |    0.4159 |
-#> |.....................|    -1.002 |    0.2127 |  -0.06061 |    -1.206 |
-#> |.....................|   -0.3333 |...........|...........|...........|
-#> |   34|     752.11747 |    0.9885 |   -0.9785 |    -1.009 |    -1.018 |
-#> |.....................|   -0.6332 |   -0.9807 |   -0.9185 |   -0.6896 |
-#> |.....................|   -0.7874 |...........|...........|...........|
-#> |    U|     752.11747 |     86.00 |    -3.209 |    -4.609 |   -0.3666 |
-#> |.....................|     4.671 |    0.6312 |    0.8687 |     1.370 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.11747 |     86.00 |   0.04039 |  0.009966 |    0.4094 |
-#> |.....................|     4.671 |    0.6312 |    0.8687 |     1.370 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.5772 |   0.02918 |   0.09258 |    0.4085 |
-#> |.....................|    -1.024 |    0.1535 |  -0.04467 |    -1.159 |
-#> |.....................|   -0.3360 |...........|...........|...........|
-#> |   35|     752.11522 |    0.9892 |   -0.9785 |    -1.009 |    -1.018 |
-#> |.....................|   -0.6319 |   -0.9809 |   -0.9185 |   -0.6881 |
-#> |.....................|   -0.7870 |...........|...........|...........|
-#> |    U|     752.11522 |     86.06 |    -3.209 |    -4.609 |   -0.3668 |
-#> |.....................|     4.674 |    0.6311 |    0.8687 |     1.371 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    X|     752.11522 |     86.06 |   0.04039 |  0.009965 |    0.4093 |
-#> |.....................|     4.674 |    0.6311 |    0.8687 |     1.371 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    F| Forward Diff. |     3.959 |   0.02535 |   0.09612 |    0.4130 |
-#> |.....................|   -0.8451 |    0.1980 |  -0.03883 |    -1.121 |
-#> |.....................|   -0.3219 |...........|...........|...........|
-#> |   36|     752.11234 |    0.9885 |   -0.9786 |    -1.009 |    -1.020 |
-#> |.....................|   -0.6320 |   -0.9808 |   -0.9183 |   -0.6870 |
-#> |.....................|   -0.7872 |...........|...........|...........|
-#> |    U|     752.11234 |     86.00 |    -3.209 |    -4.609 |   -0.3673 |
-#> |.....................|     4.673 |    0.6311 |    0.8689 |     1.373 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    X|     752.11234 |     86.00 |   0.04039 |  0.009964 |    0.4092 |
-#> |.....................|     4.673 |    0.6311 |    0.8689 |     1.373 |
-#> |.....................|     1.065 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.5042 |   0.02791 |   0.08363 |    0.4056 |
-#> |.....................|   -0.8741 |    0.1402 |  -0.02542 |    -1.088 |
-#> |.....................|   -0.3257 |...........|...........|...........|
-#> |   37|     752.11033 |    0.9892 |   -0.9787 |    -1.009 |    -1.020 |
-#> |.....................|   -0.6308 |   -0.9810 |   -0.9182 |   -0.6855 |
-#> |.....................|   -0.7868 |...........|...........|...........|
-#> |    U|     752.11033 |     86.06 |    -3.209 |    -4.609 |   -0.3675 |
-#> |.....................|     4.676 |    0.6310 |    0.8689 |     1.374 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    X|     752.11033 |     86.06 |   0.04039 |  0.009963 |    0.4091 |
-#> |.....................|     4.676 |    0.6310 |    0.8689 |     1.374 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    F| Forward Diff. |     3.874 |   0.02465 |   0.08719 |    0.4100 |
-#> |.....................|   -0.7032 |    0.1835 |  -0.01978 |    -1.047 |
-#> |.....................|   -0.3084 |...........|...........|...........|
-#> |   38|     752.10764 |    0.9885 |   -0.9787 |    -1.009 |    -1.022 |
-#> |.....................|   -0.6309 |   -0.9810 |   -0.9181 |   -0.6844 |
-#> |.....................|   -0.7870 |...........|...........|...........|
-#> |    U|     752.10764 |     86.00 |    -3.209 |    -4.609 |   -0.3681 |
-#> |.....................|     4.676 |    0.6310 |    0.8691 |     1.376 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    X|     752.10764 |     86.00 |   0.04038 |  0.009962 |    0.4090 |
-#> |.....................|     4.676 |    0.6310 |    0.8691 |     1.376 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.4131 |   0.02699 |   0.07721 |    0.4026 |
-#> |.....................|   -0.7354 |    0.1282 | -0.007503 |    -1.011 |
-#> |.....................|   -0.3125 |...........|...........|...........|
-#> |   39|     752.10572 |    0.9892 |   -0.9788 |    -1.009 |    -1.023 |
-#> |.....................|   -0.6298 |   -0.9812 |   -0.9181 |   -0.6829 |
-#> |.....................|   -0.7865 |...........|...........|...........|
-#> |    U|     752.10572 |     86.06 |    -3.209 |    -4.609 |   -0.3683 |
-#> |.....................|     4.678 |    0.6309 |    0.8691 |     1.377 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    X|     752.10572 |     86.06 |   0.04038 |  0.009960 |    0.4090 |
-#> |.....................|     4.678 |    0.6309 |    0.8691 |     1.377 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    F| Forward Diff. |     3.580 |   0.02411 |   0.07834 |    0.4067 |
-#> |.....................|   -0.5755 |    0.1666 | -0.003596 |   -0.9604 |
-#> |.....................|   -0.2924 |...........|...........|...........|
-#> |   40|     752.10333 |    0.9885 |   -0.9789 |    -1.009 |    -1.024 |
-#> |.....................|   -0.6300 |   -0.9811 |   -0.9179 |   -0.6819 |
-#> |.....................|   -0.7867 |...........|...........|...........|
-#> |    U|     752.10333 |     86.00 |    -3.209 |    -4.609 |   -0.3688 |
-#> |.....................|     4.678 |    0.6309 |    0.8692 |     1.378 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    X|     752.10333 |     86.00 |   0.04038 |  0.009959 |    0.4088 |
-#> |.....................|     4.678 |    0.6309 |    0.8692 |     1.378 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.3772 |   0.02648 |   0.06875 |    0.3997 |
-#> |.....................|   -0.6082 |    0.1162 |  0.008208 |   -0.9328 |
-#> |.....................|   -0.2962 |...........|...........|...........|
-#> |   41|     752.10169 |    0.9892 |   -0.9789 |    -1.009 |    -1.025 |
-#> |.....................|   -0.6289 |   -0.9813 |   -0.9179 |   -0.6803 |
-#> |.....................|   -0.7862 |...........|...........|...........|
-#> |    U|     752.10169 |     86.06 |    -3.209 |    -4.609 |   -0.3691 |
-#> |.....................|     4.680 |    0.6308 |    0.8692 |     1.380 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    X|     752.10169 |     86.06 |   0.04038 |  0.009958 |    0.4088 |
-#> |.....................|     4.680 |    0.6308 |    0.8692 |     1.380 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    F| Forward Diff. |     3.644 |   0.02338 |   0.07127 |    0.4037 |
-#> |.....................|   -0.4618 |    0.1554 |  0.009391 |   -0.8908 |
-#> |.....................|   -0.2755 |...........|...........|...........|
-#> |   42|     752.09938 |    0.9886 |   -0.9790 |    -1.009 |    -1.027 |
-#> |.....................|   -0.6291 |   -0.9812 |   -0.9178 |   -0.6794 |
-#> |.....................|   -0.7864 |...........|...........|...........|
-#> |    U|     752.09938 |     86.00 |    -3.210 |    -4.609 |   -0.3697 |
-#> |.....................|     4.680 |    0.6308 |    0.8693 |     1.381 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    X|     752.09938 |     86.00 |   0.04037 |  0.009958 |    0.4086 |
-#> |.....................|     4.680 |    0.6308 |    0.8693 |     1.381 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.2627 |   0.02548 |   0.06256 |    0.3967 |
-#> |.....................|   -0.4955 |    0.1055 |   0.02027 |   -0.8653 |
-#> |.....................|   -0.2789 |...........|...........|...........|
-#> |   43|     752.09757 |    0.9890 |   -0.9791 |    -1.010 |    -1.028 |
-#> |.....................|   -0.6281 |   -0.9814 |   -0.9178 |   -0.6778 |
-#> |.....................|   -0.7859 |...........|...........|...........|
-#> |    U|     752.09757 |     86.05 |    -3.210 |    -4.610 |   -0.3699 |
-#> |.....................|     4.682 |    0.6307 |    0.8693 |     1.383 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    X|     752.09757 |     86.05 |   0.04037 |  0.009956 |    0.4086 |
-#> |.....................|     4.682 |    0.6307 |    0.8693 |     1.383 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    F| Forward Diff. |     2.867 |   0.02296 |   0.06369 |    0.3997 |
-#> |.....................|   -0.3645 |    0.1327 |   0.01894 |   -0.8216 |
-#> |.....................|   -0.2549 |...........|...........|...........|
-#> |   44|     752.09570 |    0.9886 |   -0.9791 |    -1.010 |    -1.030 |
-#> |.....................|   -0.6283 |   -0.9814 |   -0.9177 |   -0.6770 |
-#> |.....................|   -0.7861 |...........|...........|...........|
-#> |    U|      752.0957 |     86.00 |    -3.210 |    -4.610 |   -0.3705 |
-#> |.....................|     4.681 |    0.6307 |    0.8694 |     1.384 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    X|      752.0957 |     86.00 |   0.04037 |  0.009956 |    0.4084 |
-#> |.....................|     4.681 |    0.6307 |    0.8694 |     1.384 |
-#> |.....................|     1.066 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.2846 |   0.02474 |   0.05675 |    0.3935 |
-#> |.....................|   -0.3960 |   0.09353 |   0.02976 |   -0.7961 |
-#> |.....................|   -0.2595 |...........|...........|...........|
-#> |   45|     752.09434 |    0.9891 |   -0.9792 |    -1.010 |    -1.030 |
-#> |.....................|   -0.6275 |   -0.9816 |   -0.9177 |   -0.6754 |
-#> |.....................|   -0.7856 |...........|...........|...........|
-#> |    U|     752.09434 |     86.05 |    -3.210 |    -4.610 |   -0.3708 |
-#> |.....................|     4.683 |    0.6306 |    0.8694 |     1.386 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    X|     752.09434 |     86.05 |   0.04037 |  0.009955 |    0.4083 |
-#> |.....................|     4.683 |    0.6306 |    0.8694 |     1.386 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    F| Forward Diff. |     3.348 |   0.02147 |   0.05816 |    0.3967 |
-#> |.....................|   -0.2833 |    0.1286 |   0.02562 |   -0.7529 |
-#> |.....................|   -0.2380 |...........|...........|...........|
-#> |   46|     752.09236 |    0.9886 |   -0.9793 |    -1.010 |    -1.032 |
-#> |.....................|   -0.6277 |   -0.9815 |   -0.9176 |   -0.6746 |
-#> |.....................|   -0.7858 |...........|...........|...........|
-#> |    U|     752.09236 |     86.01 |    -3.210 |    -4.610 |   -0.3715 |
-#> |.....................|     4.683 |    0.6306 |    0.8695 |     1.387 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    X|     752.09236 |     86.01 |   0.04036 |  0.009954 |    0.4082 |
-#> |.....................|     4.683 |    0.6306 |    0.8695 |     1.387 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    F| Forward Diff. |   -0.1856 |   0.02378 |   0.05144 |    0.3902 |
-#> |.....................|   -0.3147 |   0.08386 |   0.03545 |   -0.7433 |
-#> |.....................|   -0.2408 |...........|...........|...........|
-#> |   47|     752.09077 |    0.9890 |   -0.9793 |    -1.010 |    -1.033 |
-#> |.....................|   -0.6269 |   -0.9817 |   -0.9177 |   -0.6729 |
-#> |.....................|   -0.7852 |...........|...........|...........|
-#> |    U|     752.09077 |     86.04 |    -3.210 |    -4.610 |   -0.3717 |
-#> |.....................|     4.684 |    0.6305 |    0.8694 |     1.389 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    X|     752.09077 |     86.04 |   0.04036 |  0.009953 |    0.4081 |
-#> |.....................|     4.684 |    0.6305 |    0.8694 |     1.389 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |   48|     752.08937 |    0.9892 |   -0.9795 |    -1.010 |    -1.036 |
-#> |.....................|   -0.6267 |   -0.9818 |   -0.9176 |   -0.6714 |
-#> |.....................|   -0.7852 |...........|...........|...........|
-#> |    U|     752.08937 |     86.06 |    -3.210 |    -4.610 |   -0.3725 |
-#> |.....................|     4.685 |    0.6304 |    0.8695 |     1.391 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    X|     752.08937 |     86.06 |   0.04036 |  0.009952 |    0.4079 |
-#> |.....................|     4.685 |    0.6304 |    0.8695 |     1.391 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    F| Forward Diff. |     3.945 |   0.01952 |   0.05064 |    0.3906 |
-#> |.....................|   -0.1866 |    0.1233 |   0.03740 |   -0.6554 |
-#> |.....................|   -0.2138 |...........|...........|...........|
-#> |   49|     752.08593 |    0.9886 |   -0.9796 |    -1.010 |    -1.040 |
-#> |.....................|   -0.6271 |   -0.9817 |   -0.9174 |   -0.6701 |
-#> |.....................|   -0.7856 |...........|...........|...........|
-#> |    U|     752.08593 |     86.01 |    -3.210 |    -4.610 |   -0.3740 |
-#> |.....................|     4.684 |    0.6305 |    0.8697 |     1.392 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    X|     752.08593 |     86.01 |   0.04035 |  0.009951 |    0.4076 |
-#> |.....................|     4.684 |    0.6305 |    0.8697 |     1.392 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    F| Forward Diff. |  -0.04707 |   0.02143 |   0.04311 |    0.3795 |
-#> |.....................|   -0.2514 |   0.07631 |   0.05739 |   -0.6184 |
-#> |.....................|   -0.2313 |...........|...........|...........|
-#> |   50|     752.08243 |    0.9889 |   -0.9798 |    -1.010 |    -1.042 |
-#> |.....................|   -0.6256 |   -0.9821 |   -0.9177 |   -0.6665 |
-#> |.....................|   -0.7842 |...........|...........|...........|
-#> |    U|     752.08243 |     86.03 |    -3.210 |    -4.610 |   -0.3748 |
-#> |.....................|     4.687 |    0.6302 |    0.8694 |     1.396 |
-#> |.....................|     1.068 |...........|...........|...........|
-#> |    X|     752.08243 |     86.03 |   0.04034 |  0.009949 |    0.4074 |
-#> |.....................|     4.687 |    0.6302 |    0.8694 |     1.396 |
-#> |.....................|     1.068 |...........|...........|...........|
-#> |   51|     752.07616 |    0.9895 |   -0.9803 |    -1.011 |    -1.054 |
-#> |.....................|   -0.6231 |   -0.9827 |   -0.9181 |   -0.6582 |
-#> |.....................|   -0.7817 |...........|...........|...........|
-#> |    U|     752.07616 |     86.08 |    -3.211 |    -4.611 |   -0.3786 |
-#> |.....................|     4.693 |    0.6298 |    0.8690 |     1.406 |
-#> |.....................|     1.071 |...........|...........|...........|
-#> |    X|     752.07616 |     86.08 |   0.04032 |  0.009942 |    0.4065 |
-#> |.....................|     4.693 |    0.6298 |    0.8690 |     1.406 |
-#> |.....................|     1.071 |...........|...........|...........|
-#> |    F| Forward Diff. |     5.128 |   0.01286 |   0.03023 |    0.3726 |
-#> |.....................|    0.2708 |   0.07184 |  -0.02487 |   -0.2959 |
-#> |.....................|  -0.03882 |...........|...........|...........|
-#> |   52|     752.06706 |    0.9888 |   -0.9810 |    -1.011 |    -1.073 |
-#> |.....................|   -0.6241 |   -0.9834 |   -0.9174 |   -0.6562 |
-#> |.....................|   -0.7830 |...........|...........|...........|
-#> |    U|     752.06706 |     86.03 |    -3.212 |    -4.611 |   -0.3848 |
-#> |.....................|     4.690 |    0.6293 |    0.8696 |     1.408 |
-#> |.....................|     1.069 |...........|...........|...........|
-#> |    X|     752.06706 |     86.03 |   0.04030 |  0.009938 |    0.4050 |
-#> |.....................|     4.690 |    0.6293 |    0.8696 |     1.408 |
-#> |.....................|     1.069 |...........|...........|...........|
-#> |   53|     752.05726 |    0.9892 |   -0.9821 |    -1.012 |    -1.106 |
-#> |.....................|   -0.6257 |   -0.9847 |   -0.9162 |   -0.6528 |
-#> |.....................|   -0.7853 |...........|...........|...........|
-#> |    U|     752.05726 |     86.06 |    -3.213 |    -4.612 |   -0.3958 |
-#> |.....................|     4.687 |    0.6284 |    0.8707 |     1.412 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |    X|     752.05726 |     86.06 |   0.04025 |  0.009929 |    0.4023 |
-#> |.....................|     4.687 |    0.6284 |    0.8707 |     1.412 |
-#> |.....................|     1.067 |...........|...........|...........|
-#> |   54|     752.04392 |    0.9898 |   -0.9854 |    -1.015 |    -1.200 |
-#> |.....................|   -0.6305 |   -0.9883 |   -0.9128 |   -0.6430 |
-#> |.....................|   -0.7918 |...........|...........|...........|
-#> |    U|     752.04392 |     86.11 |    -3.216 |    -4.615 |   -0.4269 |
-#> |.....................|     4.677 |    0.6259 |    0.8738 |     1.423 |
-#> |.....................|     1.061 |...........|...........|...........|
-#> |    X|     752.04392 |     86.11 |   0.04012 |  0.009906 |    0.3949 |
-#> |.....................|     4.677 |    0.6259 |    0.8738 |     1.423 |
-#> |.....................|     1.061 |...........|...........|...........|
-#> |    F| Forward Diff. |     5.566 |  -0.02004 |   0.02472 |    0.1678 |
-#> |.....................|   -0.6767 | -0.003606 |    0.4773 |   0.08205 |
-#> |.....................|   -0.6933 |...........|...........|...........|
-#> |   55|     752.05860 |    0.9880 |   -0.9900 |    -1.027 |    -1.486 |
-#> |.....................|   -0.6186 |   -0.9338 |   -0.9168 |   -0.6653 |
-#> |.....................|   -0.7443 |...........|...........|...........|
-#> |    U|      752.0586 |     85.96 |    -3.221 |    -4.627 |   -0.5212 |
-#> |.....................|     4.702 |    0.6640 |    0.8702 |     1.398 |
-#> |.....................|     1.107 |...........|...........|...........|
-#> |    X|      752.0586 |     85.96 |   0.03993 |  0.009780 |    0.3726 |
-#> |.....................|     4.702 |    0.6640 |    0.8702 |     1.398 |
-#> |.....................|     1.107 |...........|...........|...........|
-#> |   56|     752.02137 |    0.9885 |   -0.9874 |    -1.020 |    -1.325 |
-#> |.....................|   -0.6252 |   -0.9645 |   -0.9146 |   -0.6528 |
-#> |.....................|   -0.7710 |...........|...........|...........|
-#> |    U|     752.02137 |     86.00 |    -3.218 |    -4.620 |   -0.4681 |
-#> |.....................|     4.688 |    0.6425 |    0.8722 |     1.412 |
-#> |.....................|     1.081 |...........|...........|...........|
-#> |    X|     752.02137 |     86.00 |   0.04004 |  0.009850 |    0.3851 |
-#> |.....................|     4.688 |    0.6425 |    0.8722 |     1.412 |
-#> |.....................|     1.081 |...........|...........|...........|
-#> |    F| Forward Diff. |    -1.728 |  -0.02729 |   0.08518 |   0.04185 |
-#> |.....................|   -0.2367 |    0.4063 |    0.2432 |   0.01436 |
-#> |.....................|  -0.07563 |...........|...........|...........|
-#> |   57|     752.06656 |    0.9886 |   -0.9792 |    -1.053 |    -1.433 |
-#> |.....................|   -0.6165 |    -1.020 |   -0.9133 |   -0.6801 |
-#> |.....................|   -0.7607 |...........|...........|...........|
-#> |    U|     752.06656 |     86.01 |    -3.210 |    -4.653 |   -0.5037 |
-#> |.....................|     4.707 |    0.6037 |    0.8734 |     1.380 |
-#> |.....................|     1.091 |...........|...........|...........|
-#> |    X|     752.06656 |     86.01 |   0.04036 |  0.009533 |    0.3767 |
-#> |.....................|     4.707 |    0.6037 |    0.8734 |     1.380 |
-#> |.....................|     1.091 |...........|...........|...........|
-#> |   58|     752.02137 |    0.9885 |   -0.9874 |    -1.020 |    -1.325 |
-#> |.....................|   -0.6252 |   -0.9645 |   -0.9146 |   -0.6528 |
-#> |.....................|   -0.7710 |...........|...........|...........|
-#> |    U|     752.02137 |     86.00 |    -3.218 |    -4.620 |   -0.4681 |
-#> |.....................|     4.688 |    0.6425 |    0.8722 |     1.412 |
-#> |.....................|     1.081 |...........|...........|...........|
-#> |    X|     752.02137 |     86.00 |   0.04004 |  0.009850 |    0.3851 |
-#> |.....................|     4.688 |    0.6425 |    0.8722 |     1.412 |
-#> |.....................|     1.081 |...........|...........|...........|
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-f_nlmixr_fomc_sfo_focei_const <- nlmixr(f_mmkin_const["FOMC-SFO", ], est = "focei")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
-#> F: Forward difference gradient approximation
-#> C: Central difference gradient approximation
-#> M: Mixed forward and central difference gradient approximation
-#> Unscaled parameters for Omegas=chol(solve(omega));
-#> Diagonals are transformed, as specified by foceiControl(diagXform=)
-#> |-----+---------------+-----------+-----------+-----------+-----------|
-#> |    #| Objective Fun |  parent_0 |  log_k_A1 |f_parent_qlogis | log_alpha |
-#> |.....................|  log_beta |     sigma |        o1 |        o2 |
-#> |.....................|        o3 |        o4 |        o5 |...........|
-#> |    1|     494.78160 |     1.000 |    -1.000 |   -0.9115 |   -0.8954 |
-#> |.....................|   -0.8491 |   -0.8592 |   -0.8761 |   -0.8740 |
-#> |.....................|   -0.8674 |   -0.8694 |   -0.8683 |...........|
-#> |    U|      494.7816 |     94.00 |    -5.400 |    -1.000 |   -0.2000 |
-#> |.....................|     2.100 |     1.600 |    0.7598 |    0.8633 |
-#> |.....................|     1.189 |     1.089 |     1.146 |...........|
-#> |    X|      494.7816 |     94.00 |  0.004517 |    0.2689 |    0.8187 |
-#> |.....................|     8.166 |     1.600 |    0.7598 |    0.8633 |
-#> |.....................|     1.189 |     1.089 |     1.146 |...........|
-#> |    G|    Gill Diff. |    -28.01 |     1.933 |   -0.2086 |   0.01492 |
-#> |.....................|   -0.1687 |    -59.79 |     10.74 |     9.966 |
-#> |.....................|    -11.82 |    -8.862 |    -10.52 |...........|
-#> |    2|     1353.4477 |     1.400 |    -1.028 |   -0.9085 |   -0.8956 |
-#> |.....................|   -0.8467 | -0.005584 |    -1.029 |    -1.016 |
-#> |.....................|   -0.6987 |   -0.7429 |   -0.7181 |...........|
-#> |    U|     1353.4477 |     131.6 |    -5.428 |   -0.9970 |   -0.2002 |
-#> |.....................|     2.102 |     2.283 |    0.6433 |    0.7405 |
-#> |.....................|     1.390 |     1.227 |     1.318 |...........|
-#> |    X|     1353.4477 |     131.6 |  0.004394 |    0.2695 |    0.8186 |
-#> |.....................|     8.186 |     2.283 |    0.6433 |    0.7405 |
-#> |.....................|     1.390 |     1.227 |     1.318 |...........|
-#> |    3|     504.82409 |     1.040 |    -1.003 |   -0.9112 |   -0.8954 |
-#> |.....................|   -0.8489 |   -0.7738 |   -0.8914 |   -0.8882 |
-#> |.....................|   -0.8506 |   -0.8568 |   -0.8533 |...........|
-#> |    U|     504.82409 |     97.76 |    -5.403 |   -0.9997 |   -0.2000 |
-#> |.....................|     2.100 |     1.668 |    0.7482 |    0.8511 |
-#> |.....................|     1.209 |     1.103 |     1.163 |...........|
-#> |    X|     504.82409 |     97.76 |  0.004504 |    0.2690 |    0.8187 |
-#> |.....................|     8.168 |     1.668 |    0.7482 |    0.8511 |
-#> |.....................|     1.209 |     1.103 |     1.163 |...........|
-#> |    4|     494.10898 |     1.008 |    -1.001 |   -0.9114 |   -0.8954 |
-#> |.....................|   -0.8490 |   -0.8416 |   -0.8792 |   -0.8769 |
-#> |.....................|   -0.8640 |   -0.8668 |   -0.8652 |...........|
-#> |    U|     494.10898 |     94.77 |    -5.401 |   -0.9999 |   -0.2000 |
-#> |.....................|     2.100 |     1.614 |    0.7574 |    0.8608 |
-#> |.....................|     1.193 |     1.092 |     1.149 |...........|
-#> |    X|     494.10898 |     94.77 |  0.004514 |    0.2690 |    0.8187 |
-#> |.....................|     8.167 |     1.614 |    0.7574 |    0.8608 |
-#> |.....................|     1.193 |     1.092 |     1.149 |...........|
-#> |    F| Forward Diff. |     147.0 |     1.955 |  -0.08761 |   0.06834 |
-#> |.....................|   0.05948 |    -55.61 |     11.89 |     8.304 |
-#> |.....................|    -12.01 |    -8.510 |    -10.24 |...........|
-#> |    5|     492.58255 |    0.9992 |    -1.001 |   -0.9114 |   -0.8954 |
-#> |.....................|   -0.8490 |   -0.8245 |   -0.8825 |   -0.8797 |
-#> |.....................|   -0.8605 |   -0.8643 |   -0.8621 |...........|
-#> |    U|     492.58255 |     93.93 |    -5.401 |   -0.9999 |   -0.2000 |
-#> |.....................|     2.100 |     1.628 |    0.7550 |    0.8584 |
-#> |.....................|     1.197 |     1.095 |     1.153 |...........|
-#> |    X|     492.58255 |     93.93 |  0.004511 |    0.2690 |    0.8187 |
-#> |.....................|     8.167 |     1.628 |    0.7550 |    0.8584 |
-#> |.....................|     1.197 |     1.095 |     1.153 |...........|
-#> |    F| Forward Diff. |    -43.22 |     1.882 |   -0.2206 | -0.004719 |
-#> |.....................|   -0.1970 |    -51.78 |     10.22 |     6.620 |
-#> |.....................|    -11.81 |    -8.346 |    -10.04 |...........|
-#> |    6|     491.66702 |     1.006 |    -1.002 |   -0.9113 |   -0.8954 |
-#> |.....................|   -0.8490 |   -0.8063 |   -0.8860 |   -0.8822 |
-#> |.....................|   -0.8565 |   -0.8614 |   -0.8588 |...........|
-#> |    U|     491.66702 |     94.52 |    -5.402 |   -0.9998 |   -0.2000 |
-#> |.....................|     2.100 |     1.642 |    0.7523 |    0.8562 |
-#> |.....................|     1.202 |     1.098 |     1.157 |...........|
-#> |    X|     491.66702 |     94.52 |  0.004509 |    0.2690 |    0.8187 |
-#> |.....................|     8.167 |     1.642 |    0.7523 |    0.8562 |
-#> |.....................|     1.202 |     1.098 |     1.157 |...........|
-#> |    F| Forward Diff. |     87.79 |     1.893 |   -0.1269 |   0.04418 |
-#> |.....................|  -0.01699 |    -47.85 |     10.34 |     7.758 |
-#> |.....................|    -11.67 |    -8.213 |    -9.916 |...........|
-#> |    7|     490.57489 |    0.9987 |    -1.002 |   -0.9112 |   -0.8954 |
-#> |.....................|   -0.8489 |   -0.7885 |   -0.8895 |   -0.8851 |
-#> |.....................|   -0.8525 |   -0.8586 |   -0.8553 |...........|
-#> |    U|     490.57489 |     93.88 |    -5.402 |   -0.9998 |   -0.2000 |
-#> |.....................|     2.100 |     1.657 |    0.7496 |    0.8537 |
-#> |.....................|     1.207 |     1.101 |     1.161 |...........|
-#> |    X|     490.57489 |     93.88 |  0.004506 |    0.2690 |    0.8187 |
-#> |.....................|     8.168 |     1.657 |    0.7496 |    0.8537 |
-#> |.....................|     1.207 |     1.101 |     1.161 |...........|
-#> |    F| Forward Diff. |    -52.56 |     1.834 |   -0.2285 |  -0.01046 |
-#> |.....................|   -0.2159 |    -44.44 |     9.379 |     7.248 |
-#> |.....................|    -11.47 |    -8.044 |    -9.710 |...........|
-#> |    8|     489.67804 |     1.004 |    -1.003 |   -0.9112 |   -0.8954 |
-#> |.....................|   -0.8489 |   -0.7706 |   -0.8932 |   -0.8884 |
-#> |.....................|   -0.8482 |   -0.8554 |   -0.8516 |...........|
-#> |    U|     489.67804 |     94.42 |    -5.403 |   -0.9997 |   -0.2000 |
-#> |.....................|     2.100 |     1.671 |    0.7468 |    0.8509 |
-#> |.....................|     1.212 |     1.105 |     1.165 |...........|
-#> |    X|     489.67804 |     94.42 |  0.004503 |    0.2690 |    0.8187 |
-#> |.....................|     8.168 |     1.671 |    0.7468 |    0.8509 |
-#> |.....................|     1.212 |     1.105 |     1.165 |...........|
-#> |    F| Forward Diff. |     63.10 |     1.841 |   -0.1396 |   0.03713 |
-#> |.....................|  -0.05177 |    -40.65 |     9.345 |     6.018 |
-#> |.....................|    -11.29 |    -7.879 |    -9.567 |...........|
-#> |    9|     488.80457 |    0.9984 |    -1.004 |   -0.9111 |   -0.8954 |
-#> |.....................|   -0.8488 |   -0.7529 |   -0.8970 |   -0.8913 |
-#> |.....................|   -0.8435 |   -0.8521 |   -0.8475 |...........|
-#> |    U|     488.80457 |     93.85 |    -5.404 |   -0.9996 |   -0.2000 |
-#> |.....................|     2.100 |     1.685 |    0.7439 |    0.8484 |
-#> |.....................|     1.218 |     1.108 |     1.170 |...........|
-#> |    X|     488.80457 |     93.85 |  0.004499 |    0.2690 |    0.8187 |
-#> |.....................|     8.168 |     1.685 |    0.7439 |    0.8484 |
-#> |.....................|     1.218 |     1.108 |     1.170 |...........|
-#> |    F| Forward Diff. |    -56.52 |     1.788 |   -0.2313 |  -0.01570 |
-#> |.....................|   -0.2287 |    -37.43 |     8.740 |     5.512 |
-#> |.....................|    -11.08 |    -7.680 |    -9.353 |...........|
-#> |   10|     487.98244 |     1.004 |    -1.005 |   -0.9110 |   -0.8954 |
-#> |.....................|   -0.8487 |   -0.7356 |   -0.9012 |   -0.8939 |
-#> |.....................|   -0.8380 |   -0.8482 |   -0.8428 |...........|
-#> |    U|     487.98244 |     94.36 |    -5.405 |   -0.9995 |   -0.2000 |
-#> |.....................|     2.100 |     1.699 |    0.7407 |    0.8461 |
-#> |.....................|     1.224 |     1.112 |     1.175 |...........|
-#> |    X|     487.98244 |     94.36 |  0.004495 |    0.2690 |    0.8187 |
-#> |.....................|     8.169 |     1.699 |    0.7407 |    0.8461 |
-#> |.....................|     1.224 |     1.112 |     1.175 |...........|
-#> |    F| Forward Diff. |     49.57 |     1.794 |   -0.1466 |   0.03517 |
-#> |.....................|  -0.07178 |    -34.12 |     8.494 |     6.684 |
-#> |.....................|    -10.82 |    -7.482 |    -9.140 |...........|
-#> |   11|     487.23587 |    0.9987 |    -1.006 |   -0.9109 |   -0.8954 |
-#> |.....................|   -0.8487 |   -0.7192 |   -0.9058 |   -0.8980 |
-#> |.....................|   -0.8316 |   -0.8438 |   -0.8374 |...........|
-#> |    U|     487.23587 |     93.88 |    -5.406 |   -0.9994 |   -0.2001 |
-#> |.....................|     2.100 |     1.712 |    0.7372 |    0.8426 |
-#> |.....................|     1.232 |     1.117 |     1.181 |...........|
-#> |    X|     487.23587 |     93.88 |  0.004490 |    0.2691 |    0.8187 |
-#> |.....................|     8.170 |     1.712 |    0.7372 |    0.8426 |
-#> |.....................|     1.232 |     1.117 |     1.181 |...........|
-#> |    F| Forward Diff. |    -49.22 |     1.745 |   -0.2274 | -0.009194 |
-#> |.....................|   -0.2301 |    -31.48 |     7.992 |     6.132 |
-#> |.....................|    -10.64 |    -7.269 |    -8.903 |...........|
-#> |   12|     486.53337 |     1.004 |    -1.007 |   -0.9107 |   -0.8954 |
-#> |.....................|   -0.8485 |   -0.7047 |   -0.9109 |   -0.9037 |
-#> |.....................|   -0.8240 |   -0.8386 |   -0.8310 |...........|
-#> |    U|     486.53337 |     94.34 |    -5.407 |   -0.9993 |   -0.2001 |
-#> |.....................|     2.101 |     1.724 |    0.7334 |    0.8376 |
-#> |.....................|     1.241 |     1.123 |     1.189 |...........|
-#> |    X|     486.53337 |     94.34 |  0.004484 |    0.2691 |    0.8187 |
-#> |.....................|     8.171 |     1.724 |    0.7334 |    0.8376 |
-#> |.....................|     1.241 |     1.123 |     1.189 |...........|
-#> |    F| Forward Diff. |     43.47 |     1.742 |   -0.1424 |   0.02918 |
-#> |.....................|  -0.07089 |    -28.76 |     7.629 |     4.806 |
-#> |.....................|    -10.24 |    -6.953 |    -8.584 |...........|
-#> |   13|     485.91669 |    0.9989 |    -1.009 |   -0.9105 |   -0.8955 |
-#> |.....................|   -0.8484 |   -0.6920 |   -0.9165 |   -0.9072 |
-#> |.....................|   -0.8145 |   -0.8325 |   -0.8231 |...........|
-#> |    U|     485.91669 |     93.90 |    -5.409 |   -0.9991 |   -0.2001 |
-#> |.....................|     2.101 |     1.734 |    0.7291 |    0.8346 |
-#> |.....................|     1.252 |     1.130 |     1.198 |...........|
-#> |    X|     485.91669 |     93.90 |  0.004476 |    0.2691 |    0.8187 |
-#> |.....................|     8.172 |     1.734 |    0.7291 |    0.8346 |
-#> |.....................|     1.252 |     1.130 |     1.198 |...........|
-#> |    F| Forward Diff. |    -44.30 |     1.699 |   -0.2182 |  0.001936 |
-#> |.....................|   -0.2284 |    -26.86 |     7.286 |     5.487 |
-#> |.....................|    -9.898 |    -6.659 |    -8.234 |...........|
-#> |   14|     485.33976 |     1.003 |    -1.011 |   -0.9103 |   -0.8955 |
-#> |.....................|   -0.8481 |   -0.6819 |   -0.9228 |   -0.9110 |
-#> |.....................|   -0.8035 |   -0.8257 |   -0.8143 |...........|
-#> |    U|     485.33976 |     94.29 |    -5.411 |   -0.9988 |   -0.2001 |
-#> |.....................|     2.101 |     1.742 |    0.7243 |    0.8314 |
-#> |.....................|     1.265 |     1.137 |     1.208 |...........|
-#> |    X|     485.33976 |     94.29 |  0.004467 |    0.2692 |    0.8186 |
-#> |.....................|     8.174 |     1.742 |    0.7243 |    0.8314 |
-#> |.....................|     1.265 |     1.137 |     1.208 |...........|
-#> |   15|     484.77317 |     1.003 |    -1.014 |   -0.9100 |   -0.8956 |
-#> |.....................|   -0.8479 |   -0.6718 |   -0.9302 |   -0.9153 |
-#> |.....................|   -0.7902 |   -0.8175 |   -0.8035 |...........|
-#> |    U|     484.77317 |     94.32 |    -5.414 |   -0.9986 |   -0.2002 |
-#> |.....................|     2.101 |     1.750 |    0.7187 |    0.8276 |
-#> |.....................|     1.281 |     1.146 |     1.220 |...........|
-#> |    X|     484.77317 |     94.32 |  0.004455 |    0.2692 |    0.8186 |
-#> |.....................|     8.176 |     1.750 |    0.7187 |    0.8276 |
-#> |.....................|     1.281 |     1.146 |     1.220 |...........|
-#> |   16|     483.17588 |     1.004 |    -1.023 |   -0.9091 |   -0.8958 |
-#> |.....................|   -0.8469 |   -0.6384 |   -0.9549 |   -0.9296 |
-#> |.....................|   -0.7463 |   -0.7903 |   -0.7681 |...........|
-#> |    U|     483.17588 |     94.41 |    -5.423 |   -0.9976 |   -0.2004 |
-#> |.....................|     2.102 |     1.777 |    0.6999 |    0.8153 |
-#> |.....................|     1.333 |     1.176 |     1.261 |...........|
-#> |    X|     483.17588 |     94.41 |  0.004415 |    0.2694 |    0.8184 |
-#> |.....................|     8.184 |     1.777 |    0.6999 |    0.8153 |
-#> |.....................|     1.333 |     1.176 |     1.261 |...........|
-#> |   17|     481.21481 |     1.006 |    -1.040 |   -0.9072 |   -0.8961 |
-#> |.....................|   -0.8451 |   -0.5721 |    -1.004 |   -0.9579 |
-#> |.....................|   -0.6592 |   -0.7365 |   -0.6977 |...........|
-#> |    U|     481.21481 |     94.58 |    -5.440 |   -0.9958 |   -0.2008 |
-#> |.....................|     2.104 |     1.830 |    0.6628 |    0.7909 |
-#> |.....................|     1.437 |     1.234 |     1.341 |...........|
-#> |    X|     481.21481 |     94.58 |  0.004338 |    0.2698 |    0.8181 |
-#> |.....................|     8.199 |     1.830 |    0.6628 |    0.7909 |
-#> |.....................|     1.437 |     1.234 |     1.341 |...........|
-#> |    F| Forward Diff. |     62.86 |     1.476 |   0.06730 |   0.05792 |
-#> |.....................|    0.1123 |    -8.977 |     1.055 |     2.914 |
-#> |.....................|    -3.044 |    -1.094 |    -2.299 |...........|
-#> |   18|     481.29476 |     1.000 |    -1.145 |   -0.9129 |   -0.8997 |
-#> |.....................|   -0.8485 |   -0.5378 |   -0.8985 |    -1.168 |
-#> |.....................|   -0.6228 |   -0.8149 |   -0.6969 |...........|
-#> |    U|     481.29476 |     94.03 |    -5.545 |    -1.001 |   -0.2043 |
-#> |.....................|     2.101 |     1.857 |    0.7428 |    0.6099 |
-#> |.....................|     1.480 |     1.149 |     1.342 |...........|
-#> |    X|     481.29476 |     94.03 |  0.003907 |    0.2687 |    0.8152 |
-#> |.....................|     8.171 |     1.857 |    0.7428 |    0.6099 |
-#> |.....................|     1.480 |     1.149 |     1.342 |...........|
-#> |   19|     480.77138 |     1.000 |    -1.090 |   -0.9099 |   -0.8978 |
-#> |.....................|   -0.8467 |   -0.5555 |   -0.9542 |    -1.057 |
-#> |.....................|   -0.6419 |   -0.7733 |   -0.6972 |...........|
-#> |    U|     480.77138 |     94.01 |    -5.490 |   -0.9984 |   -0.2025 |
-#> |.....................|     2.102 |     1.843 |    0.7004 |    0.7055 |
-#> |.....................|     1.457 |     1.194 |     1.342 |...........|
-#> |    X|     480.77138 |     94.01 |  0.004129 |    0.2693 |    0.8167 |
-#> |.....................|     8.186 |     1.843 |    0.7004 |    0.7055 |
-#> |.....................|     1.457 |     1.194 |     1.342 |...........|
-#> |    F| Forward Diff. |    -25.72 |     1.151 |   0.08772 | -0.007897 |
-#> |.....................|  -0.07232 |    -6.930 |     3.330 |    -2.491 |
-#> |.....................|    -2.626 |    -3.111 |    -2.500 |...........|
-#> |   20|     480.61717 |     1.001 |    -1.203 |   -0.9227 |   -0.9002 |
-#> |.....................|   -0.8503 |   -0.5418 |   -0.9405 |    -1.001 |
-#> |.....................|   -0.6281 |   -0.7705 |   -0.6908 |...........|
-#> |    U|     480.61717 |     94.09 |    -5.603 |    -1.011 |   -0.2049 |
-#> |.....................|     2.099 |     1.854 |    0.7108 |    0.7537 |
-#> |.....................|     1.474 |     1.197 |     1.349 |...........|
-#> |    X|     480.61717 |     94.09 |  0.003688 |    0.2667 |    0.8147 |
-#> |.....................|     8.156 |     1.854 |    0.7108 |    0.7537 |
-#> |.....................|     1.474 |     1.197 |     1.349 |...........|
-#> |    F| Forward Diff. |    -10.61 |    0.9224 |   -0.5881 |  -0.06621 |
-#> |.....................|   -0.1838 |    -5.929 |     3.775 |     2.798 |
-#> |.....................|    -1.936 |    -2.993 |    -2.208 |...........|
-#> |   21|     480.72130 |     1.009 |    -1.314 |   -0.9169 |   -0.9003 |
-#> |.....................|   -0.8494 |   -0.5516 |   -0.9873 |    -1.003 |
-#> |.....................|   -0.6340 |   -0.7292 |   -0.6819 |...........|
-#> |    U|      480.7213 |     94.81 |    -5.714 |    -1.005 |   -0.2049 |
-#> |.....................|     2.100 |     1.846 |    0.6753 |    0.7523 |
-#> |.....................|     1.467 |     1.242 |     1.359 |...........|
-#> |    X|      480.7213 |     94.81 |  0.003299 |    0.2679 |    0.8147 |
-#> |.....................|     8.163 |     1.846 |    0.6753 |    0.7523 |
-#> |.....................|     1.467 |     1.242 |     1.359 |...........|
-#> |   22|     480.86254 |     1.009 |    -1.247 |   -0.9202 |   -0.9002 |
-#> |.....................|   -0.8499 |   -0.5429 |   -0.9605 |    -1.003 |
-#> |.....................|   -0.6295 |   -0.7530 |   -0.6863 |...........|
-#> |    U|     480.86254 |     94.84 |    -5.647 |    -1.009 |   -0.2048 |
-#> |.....................|     2.099 |     1.853 |    0.6957 |    0.7520 |
-#> |.....................|     1.472 |     1.216 |     1.354 |...........|
-#> |    X|     480.86254 |     94.84 |  0.003530 |    0.2672 |    0.8148 |
-#> |.....................|     8.160 |     1.853 |    0.6957 |    0.7520 |
-#> |.....................|     1.472 |     1.216 |     1.354 |...........|
-#> |   23|     480.98412 |     1.009 |    -1.209 |   -0.9220 |   -0.9002 |
-#> |.....................|   -0.8501 |   -0.5381 |   -0.9458 |    -1.003 |
-#> |.....................|   -0.6270 |   -0.7661 |   -0.6887 |...........|
-#> |    U|     480.98412 |     94.85 |    -5.609 |    -1.010 |   -0.2048 |
-#> |.....................|     2.099 |     1.857 |    0.7069 |    0.7519 |
-#> |.....................|     1.475 |     1.202 |     1.352 |...........|
-#> |    X|     480.98412 |     94.85 |  0.003664 |    0.2669 |    0.8148 |
-#> |.....................|     8.158 |     1.857 |    0.7069 |    0.7519 |
-#> |.....................|     1.475 |     1.202 |     1.352 |...........|
-#> |   24|     480.60990 |     1.003 |    -1.203 |   -0.9226 |   -0.9002 |
-#> |.....................|   -0.8503 |   -0.5410 |   -0.9411 |    -1.001 |
-#> |.....................|   -0.6278 |   -0.7701 |   -0.6905 |...........|
-#> |    U|      480.6099 |     94.24 |    -5.603 |    -1.011 |   -0.2049 |
-#> |.....................|     2.099 |     1.855 |    0.7104 |    0.7534 |
-#> |.....................|     1.474 |     1.198 |     1.350 |...........|
-#> |    X|      480.6099 |     94.24 |  0.003688 |    0.2668 |    0.8148 |
-#> |.....................|     8.156 |     1.855 |    0.7104 |    0.7534 |
-#> |.....................|     1.474 |     1.198 |     1.350 |...........|
-#> |    F| Forward Diff. |     15.29 |    0.9278 |   -0.5289 |  -0.04762 |
-#> |.....................|   -0.1043 |    -5.468 |     3.876 |    0.6273 |
-#> |.....................|    -1.897 |    -2.941 |    -2.183 |...........|
-#> |   25|     480.59557 |     1.001 |    -1.204 |   -0.9225 |   -0.9002 |
-#> |.....................|   -0.8503 |   -0.5407 |   -0.9419 |    -1.001 |
-#> |.....................|   -0.6277 |   -0.7694 |   -0.6902 |...........|
-#> |    U|     480.59557 |     94.13 |    -5.604 |    -1.011 |   -0.2049 |
-#> |.....................|     2.099 |     1.855 |    0.7098 |    0.7533 |
-#> |.....................|     1.474 |     1.198 |     1.350 |...........|
-#> |    X|     480.59557 |     94.13 |  0.003683 |    0.2668 |    0.8148 |
-#> |.....................|     8.157 |     1.855 |    0.7098 |    0.7533 |
-#> |.....................|     1.474 |     1.198 |     1.350 |...........|
-#> |    F| Forward Diff. |    -4.733 |    0.9212 |   -0.5619 |  -0.05855 |
-#> |.....................|   -0.1664 |    -5.388 |     3.833 |    0.5854 |
-#> |.....................|    -1.924 |    -2.927 |    -2.102 |...........|
-#> |   26|     480.58581 |     1.002 |    -1.204 |   -0.9224 |   -0.9002 |
-#> |.....................|   -0.8502 |   -0.5395 |   -0.9428 |    -1.002 |
-#> |.....................|   -0.6273 |   -0.7688 |   -0.6897 |...........|
-#> |    U|     480.58581 |     94.23 |    -5.604 |    -1.011 |   -0.2048 |
-#> |.....................|     2.099 |     1.856 |    0.7092 |    0.7532 |
-#> |.....................|     1.475 |     1.199 |     1.351 |...........|
-#> |    X|     480.58581 |     94.23 |  0.003683 |    0.2668 |    0.8148 |
-#> |.....................|     8.157 |     1.856 |    0.7092 |    0.7532 |
-#> |.....................|     1.475 |     1.199 |     1.351 |...........|
-#> |    F| Forward Diff. |     12.31 |    0.9226 |   -0.5246 |  -0.05019 |
-#> |.....................|   -0.1134 |    -5.293 |     3.771 |    0.5822 |
-#> |.....................|    -1.938 |    -2.904 |    -2.175 |...........|
-#> |   27|     480.57360 |     1.001 |    -1.205 |   -0.9222 |   -0.9002 |
-#> |.....................|   -0.8502 |   -0.5392 |   -0.9437 |    -1.002 |
-#> |.....................|   -0.6271 |   -0.7681 |   -0.6894 |...........|
-#> |    U|      480.5736 |     94.13 |    -5.605 |    -1.011 |   -0.2048 |
-#> |.....................|     2.099 |     1.856 |    0.7085 |    0.7532 |
-#> |.....................|     1.475 |     1.200 |     1.351 |...........|
-#> |    X|      480.5736 |     94.13 |  0.003678 |    0.2668 |    0.8148 |
-#> |.....................|     8.157 |     1.856 |    0.7085 |    0.7532 |
-#> |.....................|     1.475 |     1.200 |     1.351 |...........|
-#> |    F| Forward Diff. |    -4.864 |    0.9151 |   -0.5515 |  -0.06112 |
-#> |.....................|   -0.1679 |    -5.184 |     3.617 |    0.5746 |
-#> |.....................|    -1.832 |    -2.849 |    -2.141 |...........|
-#> |   28|     480.56429 |     1.002 |    -1.206 |   -0.9220 |   -0.9002 |
-#> |.....................|   -0.8502 |   -0.5382 |   -0.9446 |    -1.002 |
-#> |.....................|   -0.6268 |   -0.7674 |   -0.6889 |...........|
-#> |    U|     480.56429 |     94.23 |    -5.606 |    -1.011 |   -0.2048 |
-#> |.....................|     2.099 |     1.857 |    0.7078 |    0.7531 |
-#> |.....................|     1.475 |     1.201 |     1.351 |...........|
-#> |    X|     480.56429 |     94.23 |  0.003676 |    0.2669 |    0.8148 |
-#> |.....................|     8.158 |     1.857 |    0.7078 |    0.7531 |
-#> |.....................|     1.475 |     1.201 |     1.351 |...........|
-#> |    F| Forward Diff. |     12.18 |    0.9169 |   -0.5105 |  -0.05061 |
-#> |.....................|   -0.1125 |    -5.131 |     3.532 |    0.5638 |
-#> |.....................|    -1.931 |    -2.821 |    -2.132 |...........|
-#> |   29|     480.55246 |     1.001 |    -1.207 |   -0.9218 |   -0.9002 |
-#> |.....................|   -0.8501 |   -0.5380 |   -0.9454 |    -1.002 |
-#> |.....................|   -0.6266 |   -0.7667 |   -0.6886 |...........|
-#> |    U|     480.55246 |     94.13 |    -5.607 |    -1.010 |   -0.2048 |
-#> |.....................|     2.099 |     1.857 |    0.7071 |    0.7532 |
-#> |.....................|     1.476 |     1.201 |     1.352 |...........|
-#> |    X|     480.55246 |     94.13 |  0.003672 |    0.2669 |    0.8148 |
-#> |.....................|     8.158 |     1.857 |    0.7071 |    0.7532 |
-#> |.....................|     1.476 |     1.201 |     1.352 |...........|
-#> |    F| Forward Diff. |    -4.480 |    0.9098 |   -0.5353 |  -0.06055 |
-#> |.....................|   -0.1647 |    -5.053 |     3.625 |    0.5654 |
-#> |.....................|    -1.860 |    -2.782 |    -2.112 |...........|
-#> |   30|     480.54335 |     1.002 |    -1.207 |   -0.9217 |   -0.9002 |
-#> |.....................|   -0.8501 |   -0.5368 |   -0.9463 |    -1.002 |
-#> |.....................|   -0.6262 |   -0.7660 |   -0.6881 |...........|
-#> |    U|     480.54335 |     94.23 |    -5.607 |    -1.010 |   -0.2048 |
-#> |.....................|     2.099 |     1.858 |    0.7065 |    0.7530 |
-#> |.....................|     1.476 |     1.202 |     1.352 |...........|
-#> |    X|     480.54335 |     94.23 |  0.003671 |    0.2669 |    0.8148 |
-#> |.....................|     8.158 |     1.858 |    0.7065 |    0.7530 |
-#> |.....................|     1.476 |     1.202 |     1.352 |...........|
-#> |    F| Forward Diff. |     12.09 |    0.9120 |   -0.4955 |  -0.05014 |
-#> |.....................|   -0.1107 |    -4.912 |     3.583 |    0.5835 |
-#> |.....................|    -1.814 |    -2.702 |    -2.057 |...........|
-#> |   31|     480.53185 |     1.001 |    -1.209 |   -0.9215 |   -0.9002 |
-#> |.....................|   -0.8500 |   -0.5366 |   -0.9472 |    -1.002 |
-#> |.....................|   -0.6260 |   -0.7654 |   -0.6878 |...........|
-#> |    U|     480.53185 |     94.13 |    -5.609 |    -1.010 |   -0.2048 |
-#> |.....................|     2.099 |     1.858 |    0.7058 |    0.7531 |
-#> |.....................|     1.476 |     1.203 |     1.353 |...........|
-#> |    X|     480.53185 |     94.13 |  0.003666 |    0.2670 |    0.8148 |
-#> |.....................|     8.158 |     1.858 |    0.7058 |    0.7531 |
-#> |.....................|     1.476 |     1.203 |     1.353 |...........|
-#> |    F| Forward Diff. |    -4.509 |    0.9048 |   -0.5214 |  -0.06027 |
-#> |.....................|   -0.1665 |    -4.870 |     3.525 |    0.5641 |
-#> |.....................|    -1.813 |    -2.699 |    -2.069 |...........|
-#> |   32|     480.52276 |     1.002 |    -1.209 |   -0.9214 |   -0.9001 |
-#> |.....................|   -0.8500 |   -0.5356 |   -0.9481 |    -1.002 |
-#> |.....................|   -0.6256 |   -0.7647 |   -0.6873 |...........|
-#> |    U|     480.52276 |     94.22 |    -5.609 |    -1.010 |   -0.2048 |
-#> |.....................|     2.099 |     1.859 |    0.7051 |    0.7530 |
-#> |.....................|     1.477 |     1.203 |     1.353 |...........|
-#> |    X|     480.52276 |     94.22 |  0.003664 |    0.2670 |    0.8148 |
-#> |.....................|     8.159 |     1.859 |    0.7051 |    0.7530 |
-#> |.....................|     1.477 |     1.203 |     1.353 |...........|
-#> |    F| Forward Diff. |     11.38 |    0.9060 |   -0.4821 |  -0.05014 |
-#> |.....................|   -0.1110 |    -4.747 |     3.479 |    0.5798 |
-#> |.....................|    -1.777 |    -2.636 |    -2.020 |...........|
-#> |   33|     480.51194 |     1.001 |    -1.211 |   -0.9212 |   -0.9001 |
-#> |.....................|   -0.8500 |   -0.5355 |   -0.9490 |    -1.002 |
-#> |.....................|   -0.6255 |   -0.7641 |   -0.6869 |...........|
-#> |    U|     480.51194 |     94.13 |    -5.611 |    -1.010 |   -0.2048 |
-#> |.....................|     2.099 |     1.859 |    0.7044 |    0.7530 |
-#> |.....................|     1.477 |     1.204 |     1.354 |...........|
-#> |    X|     480.51194 |     94.13 |  0.003659 |    0.2670 |    0.8148 |
-#> |.....................|     8.159 |     1.859 |    0.7044 |    0.7530 |
-#> |.....................|     1.477 |     1.204 |     1.354 |...........|
-#> |    F| Forward Diff. |    -4.485 |    0.8991 |   -0.5064 |  -0.06148 |
-#> |.....................|   -0.1643 |    -4.758 |     3.403 |    0.5432 |
-#> |.....................|    -1.772 |    -2.633 |    -2.022 |...........|
-#> |   34|     480.50302 |     1.002 |    -1.211 |   -0.9210 |   -0.9001 |
-#> |.....................|   -0.8499 |   -0.5345 |   -0.9500 |    -1.002 |
-#> |.....................|   -0.6251 |   -0.7633 |   -0.6864 |...........|
-#> |    U|     480.50302 |     94.22 |    -5.611 |    -1.010 |   -0.2047 |
-#> |.....................|     2.099 |     1.860 |    0.7037 |    0.7529 |
-#> |.....................|     1.477 |     1.205 |     1.354 |...........|
-#> |    X|     480.50302 |     94.22 |  0.003656 |    0.2671 |    0.8149 |
-#> |.....................|     8.159 |     1.860 |    0.7037 |    0.7529 |
-#> |.....................|     1.477 |     1.205 |     1.354 |...........|
-#> |    F| Forward Diff. |     10.83 |    0.8997 |   -0.4680 |  -0.05021 |
-#> |.....................|   -0.1106 |    -4.703 |     3.332 |    0.5674 |
-#> |.....................|    -1.765 |    -2.559 |    -1.986 |...........|
-#> |   35|     480.49281 |     1.001 |    -1.213 |   -0.9209 |   -0.9001 |
-#> |.....................|   -0.8499 |   -0.5344 |   -0.9509 |    -1.002 |
-#> |.....................|   -0.6250 |   -0.7627 |   -0.6860 |...........|
-#> |    U|     480.49281 |     94.13 |    -5.613 |    -1.009 |   -0.2047 |
-#> |.....................|     2.099 |     1.860 |    0.7030 |    0.7529 |
-#> |.....................|     1.478 |     1.206 |     1.355 |...........|
-#> |    X|     480.49281 |     94.13 |  0.003652 |    0.2671 |    0.8149 |
-#> |.....................|     8.160 |     1.860 |    0.7030 |    0.7529 |
-#> |.....................|     1.478 |     1.206 |     1.355 |...........|
-#> |    F| Forward Diff. |    -4.447 |    0.8934 |   -0.4900 |  -0.06030 |
-#> |.....................|   -0.1577 |    -4.708 |     3.266 |    0.5080 |
-#> |.....................|    -1.782 |    -2.544 |    -1.983 |...........|
-#> |   36|     480.48415 |     1.002 |    -1.213 |   -0.9207 |   -0.9001 |
-#> |.....................|   -0.8498 |   -0.5335 |   -0.9518 |    -1.002 |
-#> |.....................|   -0.6246 |   -0.7620 |   -0.6855 |...........|
-#> |    U|     480.48415 |     94.22 |    -5.613 |    -1.009 |   -0.2047 |
-#> |.....................|     2.099 |     1.861 |    0.7023 |    0.7528 |
-#> |.....................|     1.478 |     1.206 |     1.355 |...........|
-#> |    X|     480.48415 |     94.22 |  0.003649 |    0.2671 |    0.8149 |
-#> |.....................|     8.160 |     1.861 |    0.7023 |    0.7528 |
-#> |.....................|     1.478 |     1.206 |     1.355 |...........|
-#> |    F| Forward Diff. |     10.47 |    0.8932 |   -0.4526 |  -0.04997 |
-#> |.....................|   -0.1093 |    -4.502 |     3.250 |    0.5653 |
-#> |.....................|    -1.769 |    -2.486 |    -1.944 |...........|
-#> |   37|     480.47437 |     1.001 |    -1.215 |   -0.9205 |   -0.9001 |
-#> |.....................|   -0.8498 |   -0.5334 |   -0.9527 |    -1.002 |
-#> |.....................|   -0.6244 |   -0.7613 |   -0.6852 |...........|
-#> |    U|     480.47437 |     94.13 |    -5.615 |    -1.009 |   -0.2047 |
-#> |.....................|     2.099 |     1.861 |    0.7016 |    0.7528 |
-#> |.....................|     1.478 |     1.207 |     1.356 |...........|
-#> |    X|     480.47437 |     94.13 |  0.003644 |    0.2672 |    0.8149 |
-#> |.....................|     8.161 |     1.861 |    0.7016 |    0.7528 |
-#> |.....................|     1.478 |     1.207 |     1.356 |...........|
-#> |    F| Forward Diff. |    -4.431 |    0.8869 |   -0.4735 |  -0.05983 |
-#> |.....................|   -0.1554 |    -4.492 |     3.189 |   -0.6996 |
-#> |.....................|    -1.700 |    -2.467 |    -1.937 |...........|
-#> |   38|     480.46651 |     1.002 |    -1.216 |   -0.9203 |   -0.9000 |
-#> |.....................|   -0.8497 |   -0.5326 |   -0.9537 |    -1.002 |
-#> |.....................|   -0.6240 |   -0.7606 |   -0.6847 |...........|
-#> |    U|     480.46651 |     94.21 |    -5.616 |    -1.009 |   -0.2047 |
-#> |.....................|     2.099 |     1.861 |    0.7009 |    0.7530 |
-#> |.....................|     1.479 |     1.208 |     1.356 |...........|
-#> |    X|     480.46651 |     94.21 |  0.003640 |    0.2672 |    0.8149 |
-#> |.....................|     8.161 |     1.861 |    0.7009 |    0.7530 |
-#> |.....................|     1.479 |     1.208 |     1.356 |...........|
-#> |    F| Forward Diff. |     9.502 |    0.8860 |   -0.4381 |  -0.05035 |
-#> |.....................|   -0.1103 |    -4.453 |     3.114 |    0.5384 |
-#> |.....................|    -1.770 |    -2.407 |    -1.897 |...........|
-#> |   39|     480.45755 |     1.001 |    -1.217 |   -0.9200 |   -0.9000 |
-#> |.....................|   -0.8497 |   -0.5325 |   -0.9546 |    -1.002 |
-#> |.....................|   -0.6238 |   -0.7600 |   -0.6843 |...........|
-#> |    U|     480.45755 |     94.13 |    -5.617 |    -1.009 |   -0.2047 |
-#> |.....................|     2.099 |     1.861 |    0.7002 |    0.7530 |
-#> |.....................|     1.479 |     1.209 |     1.357 |...........|
-#> |    X|     480.45755 |     94.13 |  0.003635 |    0.2673 |    0.8149 |
-#> |.....................|     8.162 |     1.861 |    0.7002 |    0.7530 |
-#> |.....................|     1.479 |     1.209 |     1.357 |...........|
-#> |    F| Forward Diff. |    -4.779 |    0.8798 |   -0.4544 |  -0.05816 |
-#> |.....................|   -0.1541 |    -4.432 |     3.060 |    0.5236 |
-#> |.....................|    -1.719 |    -2.365 |    -1.874 |...........|
-#> |   40|     480.44943 |     1.002 |    -1.218 |   -0.9199 |   -0.9000 |
-#> |.....................|   -0.8496 |   -0.5319 |   -0.9555 |    -1.002 |
-#> |.....................|   -0.6235 |   -0.7592 |   -0.6838 |...........|
-#> |    U|     480.44943 |     94.21 |    -5.618 |    -1.008 |   -0.2046 |
-#> |.....................|     2.099 |     1.862 |    0.6995 |    0.7529 |
-#> |.....................|     1.479 |     1.209 |     1.357 |...........|
-#> |    X|     480.44943 |     94.21 |  0.003631 |    0.2673 |    0.8149 |
-#> |.....................|     8.162 |     1.862 |    0.6995 |    0.7529 |
-#> |.....................|     1.479 |     1.209 |     1.357 |...........|
-#> |    F| Forward Diff. |     8.806 |    0.8785 |   -0.4202 |  -0.05024 |
-#> |.....................|   -0.1124 |    -4.289 |     3.039 |    0.5974 |
-#> |.....................|    -1.651 |    -2.322 |    -1.843 |...........|
-#> |   41|     480.44100 |     1.001 |    -1.220 |   -0.9197 |   -0.9000 |
-#> |.....................|   -0.8496 |   -0.5318 |   -0.9564 |    -1.002 |
-#> |.....................|   -0.6233 |   -0.7586 |   -0.6835 |...........|
-#> |    U|       480.441 |     94.13 |    -5.620 |    -1.008 |   -0.2046 |
-#> |.....................|     2.100 |     1.862 |    0.6988 |    0.7529 |
-#> |.....................|     1.480 |     1.210 |     1.358 |...........|
-#> |    X|       480.441 |     94.13 |  0.003626 |    0.2673 |    0.8150 |
-#> |.....................|     8.162 |     1.862 |    0.6988 |    0.7529 |
-#> |.....................|     1.480 |     1.210 |     1.358 |...........|
-#> |    F| Forward Diff. |    -4.662 |    0.8724 |   -0.4382 |  -0.05735 |
-#> |.....................|   -0.1541 |    -4.192 |     3.008 |    0.5718 |
-#> |.....................|    -1.633 |    -2.283 |    -1.828 |...........|
-#> |   42|     480.43316 |     1.002 |    -1.221 |   -0.9195 |   -0.9000 |
-#> |.....................|   -0.8495 |   -0.5313 |   -0.9573 |    -1.002 |
-#> |.....................|   -0.6230 |   -0.7579 |   -0.6830 |...........|
-#> |    U|     480.43316 |     94.21 |    -5.621 |    -1.008 |   -0.2046 |
-#> |.....................|     2.100 |     1.862 |    0.6981 |    0.7529 |
-#> |.....................|     1.480 |     1.211 |     1.358 |...........|
-#> |    X|     480.43316 |     94.21 |  0.003622 |    0.2674 |    0.8150 |
-#> |.....................|     8.163 |     1.862 |    0.6981 |    0.7529 |
-#> |.....................|     1.480 |     1.211 |     1.358 |...........|
-#> |    F| Forward Diff. |     8.374 |    0.8709 |   -0.4057 |  -0.04981 |
-#> |.....................|   -0.1077 |    -4.274 |     2.898 |    0.5670 |
-#> |.....................|    -1.709 |    -2.249 |    -1.806 |...........|
-#> |   43|     480.42514 |     1.001 |    -1.222 |   -0.9194 |   -0.8999 |
-#> |.....................|   -0.8495 |   -0.5312 |   -0.9582 |    -1.002 |
-#> |.....................|   -0.6227 |   -0.7573 |   -0.6826 |...........|
-#> |    U|     480.42514 |     94.13 |    -5.622 |    -1.008 |   -0.2046 |
-#> |.....................|     2.100 |     1.862 |    0.6974 |    0.7529 |
-#> |.....................|     1.480 |     1.212 |     1.359 |...........|
-#> |    X|     480.42514 |     94.13 |  0.003617 |    0.2674 |    0.8150 |
-#> |.....................|     8.163 |     1.862 |    0.6974 |    0.7529 |
-#> |.....................|     1.480 |     1.212 |     1.359 |...........|
-#> |    F| Forward Diff. |    -4.560 |    0.8648 |   -0.4238 |  -0.05673 |
-#> |.....................|   -0.1505 |    -4.130 |     2.894 |    0.5588 |
-#> |.....................|    -1.637 |    -2.210 |    -1.785 |...........|
-#> |   44|     480.41757 |     1.002 |    -1.223 |   -0.9192 |   -0.8999 |
-#> |.....................|   -0.8494 |   -0.5307 |   -0.9591 |    -1.002 |
-#> |.....................|   -0.6223 |   -0.7566 |   -0.6821 |...........|
-#> |    U|     480.41757 |     94.21 |    -5.623 |    -1.008 |   -0.2046 |
-#> |.....................|     2.100 |     1.863 |    0.6967 |    0.7528 |
-#> |.....................|     1.481 |     1.212 |     1.359 |...........|
-#> |    X|     480.41757 |     94.21 |  0.003613 |    0.2674 |    0.8150 |
-#> |.....................|     8.164 |     1.863 |    0.6967 |    0.7528 |
-#> |.....................|     1.481 |     1.212 |     1.359 |...........|
-#> |    F| Forward Diff. |     8.260 |    0.8632 |   -0.3905 |  -0.04898 |
-#> |.....................|   -0.1050 |    -4.163 |     2.793 |    0.5626 |
-#> |.....................|    -1.680 |    -2.170 |    -1.767 |...........|
-#> |   45|     480.40986 |     1.001 |    -1.225 |   -0.9190 |   -0.8999 |
-#> |.....................|   -0.8494 |   -0.5306 |   -0.9600 |    -1.002 |
-#> |.....................|   -0.6221 |   -0.7560 |   -0.6818 |...........|
-#> |    U|     480.40986 |     94.13 |    -5.625 |    -1.008 |   -0.2045 |
-#> |.....................|     2.100 |     1.863 |    0.6961 |    0.7528 |
-#> |.....................|     1.481 |     1.213 |     1.360 |...........|
-#> |    X|     480.40986 |     94.13 |  0.003607 |    0.2675 |    0.8150 |
-#> |.....................|     8.164 |     1.863 |    0.6961 |    0.7528 |
-#> |.....................|     1.481 |     1.213 |     1.360 |...........|
-#> |    F| Forward Diff. |    -4.433 |    0.8570 |   -0.4082 |  -0.05598 |
-#> |.....................|   -0.1439 |    -4.083 |     2.776 |   -0.7191 |
-#> |.....................|    -1.623 |    -2.134 |    -1.744 |...........|
-#> |   46|     480.40309 |     1.002 |    -1.226 |   -0.9188 |   -0.8999 |
-#> |.....................|   -0.8493 |   -0.5301 |   -0.9609 |    -1.002 |
-#> |.....................|   -0.6217 |   -0.7553 |   -0.6813 |...........|
-#> |    U|     480.40309 |     94.20 |    -5.626 |    -1.007 |   -0.2045 |
-#> |.....................|     2.100 |     1.863 |    0.6954 |    0.7529 |
-#> |.....................|     1.481 |     1.214 |     1.360 |...........|
-#> |    X|     480.40309 |     94.20 |  0.003603 |    0.2675 |    0.8151 |
-#> |.....................|     8.165 |     1.863 |    0.6954 |    0.7529 |
-#> |.....................|     1.481 |     1.214 |     1.360 |...........|
-#> |    F| Forward Diff. |     7.640 |    0.8551 |   -0.3719 |  -0.04853 |
-#> |.....................|   -0.1037 |    -4.111 |     2.689 |    0.5674 |
-#> |.....................|    -1.653 |    -2.095 |    -1.726 |...........|
-#> |   47|     480.39597 |     1.001 |    -1.227 |   -0.9185 |   -0.8998 |
-#> |.....................|   -0.8492 |   -0.5300 |   -0.9618 |    -1.002 |
-#> |.....................|   -0.6215 |   -0.7547 |   -0.6809 |...........|
-#> |    U|     480.39597 |     94.13 |    -5.627 |    -1.007 |   -0.2045 |
-#> |.....................|     2.100 |     1.863 |    0.6947 |    0.7530 |
-#> |.....................|     1.482 |     1.214 |     1.361 |...........|
-#> |    X|     480.39597 |     94.13 |  0.003598 |    0.2676 |    0.8151 |
-#> |.....................|     8.165 |     1.863 |    0.6947 |    0.7530 |
-#> |.....................|     1.482 |     1.214 |     1.361 |...........|
-#> |    F| Forward Diff. |    -4.827 |    0.8487 |   -0.3865 |  -0.05558 |
-#> |.....................|   -0.1453 |    -3.997 |     2.662 |    0.5449 |
-#> |.....................|    -1.580 |    -2.061 |    -1.701 |...........|
-#> |   48|     480.38900 |     1.002 |    -1.229 |   -0.9184 |   -0.8998 |
-#> |.....................|   -0.8491 |   -0.5297 |   -0.9626 |    -1.002 |
-#> |.....................|   -0.6211 |   -0.7540 |   -0.6805 |...........|
-#> |    U|       480.389 |     94.20 |    -5.629 |    -1.007 |   -0.2044 |
-#> |.....................|     2.100 |     1.864 |    0.6940 |    0.7529 |
-#> |.....................|     1.482 |     1.215 |     1.361 |...........|
-#> |    X|       480.389 |     94.20 |  0.003593 |    0.2676 |    0.8151 |
-#> |.....................|     8.166 |     1.864 |    0.6940 |    0.7529 |
-#> |.....................|     1.482 |     1.215 |     1.361 |...........|
-#> |    F| Forward Diff. |     7.052 |    0.8465 |   -0.3544 |  -0.04836 |
-#> |.....................|   -0.1022 |    -3.917 |     2.636 |    0.5926 |
-#> |.....................|    -1.553 |    -2.027 |    -1.689 |...........|
-#> |   49|     480.38219 |     1.001 |    -1.230 |   -0.9183 |   -0.8998 |
-#> |.....................|   -0.8491 |   -0.5296 |   -0.9634 |    -1.002 |
-#> |.....................|   -0.6209 |   -0.7534 |   -0.6801 |...........|
-#> |    U|     480.38219 |     94.13 |    -5.630 |    -1.007 |   -0.2044 |
-#> |.....................|     2.100 |     1.864 |    0.6934 |    0.7529 |
-#> |.....................|     1.482 |     1.216 |     1.362 |...........|
-#> |    X|     480.38219 |     94.13 |  0.003587 |    0.2676 |    0.8151 |
-#> |.....................|     8.166 |     1.864 |    0.6934 |    0.7529 |
-#> |.....................|     1.482 |     1.216 |     1.362 |...........|
-#> |    F| Forward Diff. |    -4.619 |    0.8406 |   -0.3725 |  -0.05439 |
-#> |.....................|   -0.1411 |    -3.915 |     2.594 |   -0.6808 |
-#> |.....................|    -1.519 |    -1.986 |    -1.659 |...........|
-#> |   50|     480.37598 |     1.002 |    -1.232 |   -0.9180 |   -0.8998 |
-#> |.....................|   -0.8490 |   -0.5292 |   -0.9644 |    -1.002 |
-#> |.....................|   -0.6206 |   -0.7528 |   -0.6796 |...........|
-#> |    U|     480.37598 |     94.20 |    -5.632 |    -1.007 |   -0.2044 |
-#> |.....................|     2.100 |     1.864 |    0.6927 |    0.7530 |
-#> |.....................|     1.483 |     1.216 |     1.362 |...........|
-#> |    X|     480.37598 |     94.20 |  0.003582 |    0.2677 |    0.8152 |
-#> |.....................|     8.167 |     1.864 |    0.6927 |    0.7530 |
-#> |.....................|     1.483 |     1.216 |     1.362 |...........|
-#> |    F| Forward Diff. |     6.566 |    0.8383 |   -0.3380 |  -0.04700 |
-#> |.....................|  -0.09943 |    -3.949 |     2.377 |    0.5751 |
-#> |.....................|    -1.561 |    -1.951 |    -1.641 |...........|
-#> |   51|     480.36982 |     1.001 |    -1.233 |   -0.9178 |   -0.8997 |
-#> |.....................|   -0.8489 |   -0.5291 |   -0.9651 |    -1.002 |
-#> |.....................|   -0.6204 |   -0.7522 |   -0.6792 |...........|
-#> |    U|     480.36982 |     94.12 |    -5.633 |    -1.006 |   -0.2043 |
-#> |.....................|     2.100 |     1.864 |    0.6922 |    0.7530 |
-#> |.....................|     1.483 |     1.217 |     1.363 |...........|
-#> |    X|     480.36982 |     94.12 |  0.003577 |    0.2677 |    0.8152 |
-#> |.....................|     8.167 |     1.864 |    0.6922 |    0.7530 |
-#> |.....................|     1.483 |     1.217 |     1.363 |...........|
-#> |    F| Forward Diff. |    -5.243 |    0.8317 |   -0.3515 |  -0.05392 |
-#> |.....................|   -0.1358 |    -3.830 |     2.493 |    0.5823 |
-#> |.....................|    -1.510 |    -1.918 |    -1.620 |...........|
-#> |   52|     480.36331 |     1.002 |    -1.235 |   -0.9176 |   -0.8997 |
-#> |.....................|   -0.8489 |   -0.5289 |   -0.9659 |    -1.002 |
-#> |.....................|   -0.6201 |   -0.7516 |   -0.6788 |...........|
-#> |    U|     480.36331 |     94.19 |    -5.635 |    -1.006 |   -0.2043 |
-#> |.....................|     2.100 |     1.864 |    0.6916 |    0.7530 |
-#> |.....................|     1.483 |     1.218 |     1.363 |...........|
-#> |    X|     480.36331 |     94.19 |  0.003572 |    0.2677 |    0.8152 |
-#> |.....................|     8.168 |     1.864 |    0.6916 |    0.7530 |
-#> |.....................|     1.483 |     1.218 |     1.363 |...........|
-#> |    F| Forward Diff. |     5.492 |    0.8288 |   -0.3226 |  -0.04732 |
-#> |.....................|  -0.09956 |    -3.829 |     2.435 |    0.5676 |
-#> |.....................|    -1.517 |    -1.882 |    -1.604 |...........|
-#> |   53|     480.35731 |     1.001 |    -1.236 |   -0.9175 |   -0.8996 |
-#> |.....................|   -0.8488 |   -0.5288 |   -0.9666 |    -1.002 |
-#> |.....................|   -0.6198 |   -0.7510 |   -0.6783 |...........|
-#> |    U|     480.35731 |     94.12 |    -5.636 |    -1.006 |   -0.2043 |
-#> |.....................|     2.100 |     1.864 |    0.6910 |    0.7529 |
-#> |.....................|     1.484 |     1.218 |     1.364 |...........|
-#> |    X|     480.35731 |     94.12 |  0.003566 |    0.2678 |    0.8152 |
-#> |.....................|     8.168 |     1.864 |    0.6910 |    0.7529 |
-#> |.....................|     1.484 |     1.218 |     1.364 |...........|
-#> |    F| Forward Diff. |    -5.442 |    0.8230 |   -0.3401 |  -0.05270 |
-#> |.....................|   -0.1329 |    -3.818 |     2.394 |   -0.6865 |
-#> |.....................|    -1.462 |    -1.826 |    -1.568 |...........|
-#> |   54|     480.35158 |     1.002 |    -1.238 |   -0.9173 |   -0.8996 |
-#> |.....................|   -0.8487 |   -0.5286 |   -0.9675 |    -1.002 |
-#> |.....................|   -0.6197 |   -0.7504 |   -0.6779 |...........|
-#> |    U|     480.35158 |     94.19 |    -5.638 |    -1.006 |   -0.2042 |
-#> |.....................|     2.100 |     1.864 |    0.6904 |    0.7530 |
-#> |.....................|     1.484 |     1.219 |     1.364 |...........|
-#> |    X|     480.35158 |     94.19 |  0.003561 |    0.2678 |    0.8153 |
-#> |.....................|     8.169 |     1.864 |    0.6904 |    0.7530 |
-#> |.....................|     1.484 |     1.219 |     1.364 |...........|
-#> |    F| Forward Diff. |     5.119 |    0.8198 |   -0.3066 |  -0.04724 |
-#> |.....................|   -0.1005 |    -3.787 |     2.338 |    0.5896 |
-#> |.....................|    -1.465 |    -1.812 |    -1.559 |...........|
-#> |   55|     480.34603 |     1.001 |    -1.239 |   -0.9170 |   -0.8996 |
-#> |.....................|   -0.8486 |   -0.5283 |   -0.9683 |    -1.002 |
-#> |.....................|   -0.6195 |   -0.7499 |   -0.6775 |...........|
-#> |    U|     480.34603 |     94.12 |    -5.639 |    -1.006 |   -0.2042 |
-#> |.....................|     2.100 |     1.865 |    0.6897 |    0.7530 |
-#> |.....................|     1.484 |     1.220 |     1.364 |...........|
-#> |    X|     480.34603 |     94.12 |  0.003555 |    0.2679 |    0.8153 |
-#> |.....................|     8.170 |     1.865 |    0.6897 |    0.7530 |
-#> |.....................|     1.484 |     1.220 |     1.364 |...........|
-#> |    F| Forward Diff. |    -5.669 |    0.8137 |   -0.3182 |  -0.05158 |
-#> |.....................|   -0.1292 |    -3.845 |     2.251 |    0.5349 |
-#> |.....................|    -1.532 |    -1.781 |    -1.537 |...........|
-#> |   56|     480.33997 |     1.002 |    -1.241 |   -0.9169 |   -0.8995 |
-#> |.....................|   -0.8486 |   -0.5282 |   -0.9690 |    -1.002 |
-#> |.....................|   -0.6192 |   -0.7493 |   -0.6772 |...........|
-#> |    U|     480.33997 |     94.19 |    -5.641 |    -1.005 |   -0.2041 |
-#> |.....................|     2.101 |     1.865 |    0.6892 |    0.7529 |
-#> |.....................|     1.484 |     1.220 |     1.365 |...........|
-#> |    X|     480.33997 |     94.19 |  0.003550 |    0.2679 |    0.8153 |
-#> |.....................|     8.170 |     1.865 |    0.6892 |    0.7529 |
-#> |.....................|     1.484 |     1.220 |     1.365 |...........|
-#> |    F| Forward Diff. |     4.944 |    0.8109 |   -0.2900 |  -0.04418 |
-#> |.....................|  -0.09220 |    -3.817 |     2.207 |    0.5423 |
-#> |.....................|    -1.530 |    -1.750 |    -1.524 |...........|
-#> |   57|     480.33440 |     1.001 |    -1.242 |   -0.9168 |   -0.8995 |
-#> |.....................|   -0.8485 |   -0.5280 |   -0.9697 |    -1.002 |
-#> |.....................|   -0.6188 |   -0.7487 |   -0.6768 |...........|
-#> |    U|      480.3344 |     94.12 |    -5.642 |    -1.005 |   -0.2041 |
-#> |.....................|     2.101 |     1.865 |    0.6887 |    0.7529 |
-#> |.....................|     1.485 |     1.221 |     1.365 |...........|
-#> |    X|      480.3344 |     94.12 |  0.003544 |    0.2679 |    0.8154 |
-#> |.....................|     8.171 |     1.865 |    0.6887 |    0.7529 |
-#> |.....................|     1.485 |     1.221 |     1.365 |...........|
-#> |    F| Forward Diff. |    -5.630 |    0.8048 |   -0.3070 |  -0.04965 |
-#> |.....................|   -0.1246 |    -3.770 |     2.179 |    0.5400 |
-#> |.....................|    -1.465 |    -1.710 |    -1.500 |...........|
-#> |   58|     480.32852 |     1.002 |    -1.244 |   -0.9167 |   -0.8994 |
-#> |.....................|   -0.8485 |   -0.5278 |   -0.9703 |    -1.002 |
-#> |.....................|   -0.6184 |   -0.7482 |   -0.6764 |...........|
-#> |    U|     480.32852 |     94.19 |    -5.644 |    -1.005 |   -0.2041 |
-#> |.....................|     2.101 |     1.865 |    0.6882 |    0.7528 |
-#> |.....................|     1.485 |     1.221 |     1.366 |...........|
-#> |    X|     480.32852 |     94.19 |  0.003538 |    0.2679 |    0.8154 |
-#> |.....................|     8.171 |     1.865 |    0.6882 |    0.7528 |
-#> |.....................|     1.485 |     1.221 |     1.366 |...........|
-#> |    F| Forward Diff. |     4.819 |    0.8018 |   -0.2789 |  -0.04260 |
-#> |.....................|  -0.08823 |    -3.653 |     2.177 |   -0.6593 |
-#> |.....................|    -1.384 |    -1.678 |    -1.478 |...........|
-#> |   59|     480.32382 |     1.001 |    -1.246 |   -0.9164 |   -0.8994 |
-#> |.....................|   -0.8484 |   -0.5276 |   -0.9711 |    -1.002 |
-#> |.....................|   -0.6183 |   -0.7477 |   -0.6761 |...........|
-#> |    U|     480.32382 |     94.12 |    -5.646 |    -1.005 |   -0.2040 |
-#> |.....................|     2.101 |     1.865 |    0.6876 |    0.7529 |
-#> |.....................|     1.486 |     1.222 |     1.366 |...........|
-#> |    X|     480.32382 |     94.12 |  0.003533 |    0.2680 |    0.8155 |
-#> |.....................|     8.172 |     1.865 |    0.6876 |    0.7529 |
-#> |.....................|     1.486 |     1.222 |     1.366 |...........|
-#> |    F| Forward Diff. |    -5.225 |    0.7951 |   -0.2896 |  -0.04843 |
-#> |.....................|   -0.1194 |    -3.720 |     2.091 |   -0.7072 |
-#> |.....................|    -1.430 |    -1.641 |    -1.454 |...........|
-#> |   60|     480.31902 |     1.002 |    -1.247 |   -0.9160 |   -0.8993 |
-#> |.....................|   -0.8482 |   -0.5273 |   -0.9719 |    -1.002 |
-#> |.....................|   -0.6182 |   -0.7473 |   -0.6757 |...........|
-#> |    U|     480.31902 |     94.19 |    -5.647 |    -1.005 |   -0.2039 |
-#> |.....................|     2.101 |     1.865 |    0.6870 |    0.7531 |
-#> |.....................|     1.486 |     1.222 |     1.367 |...........|
-#> |    X|     480.31902 |     94.19 |  0.003527 |    0.2681 |    0.8155 |
-#> |.....................|     8.173 |     1.865 |    0.6870 |    0.7531 |
-#> |.....................|     1.486 |     1.222 |     1.367 |...........|
-#> |    F| Forward Diff. |     4.904 |    0.7922 |   -0.2469 |  -0.04034 |
-#> |.....................|  -0.08539 |    -3.545 |     2.094 |   -0.6237 |
-#> |.....................|    -1.331 |    -1.619 |    -1.454 |...........|
-#> |   61|     480.31471 |     1.001 |    -1.249 |   -0.9156 |   -0.8993 |
-#> |.....................|   -0.8481 |   -0.5271 |   -0.9727 |    -1.001 |
-#> |.....................|   -0.6181 |   -0.7468 |   -0.6753 |...........|
-#> |    U|     480.31471 |     94.12 |    -5.649 |    -1.004 |   -0.2039 |
-#> |.....................|     2.101 |     1.866 |    0.6864 |    0.7533 |
-#> |.....................|     1.486 |     1.223 |     1.367 |...........|
-#> |    X|     480.31471 |     94.12 |  0.003522 |    0.2681 |    0.8156 |
-#> |.....................|     8.174 |     1.866 |    0.6864 |    0.7533 |
-#> |.....................|     1.486 |     1.223 |     1.367 |...........|
-#> |    F| Forward Diff. |    -5.295 |    0.7853 |   -0.2507 |  -0.04627 |
-#> |.....................|   -0.1126 |    -3.760 |     1.942 |   -0.7288 |
-#> |.....................|    -1.482 |    -1.617 |    -1.436 |...........|
-#> |   62|     480.31013 |     1.002 |    -1.250 |   -0.9152 |   -0.8992 |
-#> |.....................|   -0.8480 |   -0.5269 |   -0.9734 |    -1.001 |
-#> |.....................|   -0.6180 |   -0.7464 |   -0.6750 |...........|
-#> |    U|     480.31013 |     94.19 |    -5.650 |    -1.004 |   -0.2038 |
-#> |.....................|     2.101 |     1.866 |    0.6859 |    0.7535 |
-#> |.....................|     1.486 |     1.223 |     1.367 |...........|
-#> |    X|     480.31013 |     94.19 |  0.003516 |    0.2682 |    0.8156 |
-#> |.....................|     8.175 |     1.866 |    0.6859 |    0.7535 |
-#> |.....................|     1.486 |     1.223 |     1.367 |...........|
-#> |    F| Forward Diff. |     4.435 |    0.7821 |   -0.2118 |  -0.03855 |
-#> |.....................|  -0.07590 |    -3.495 |     2.000 |   -0.6027 |
-#> |.....................|    -1.382 |    -1.576 |    -1.413 |...........|
-#> |   63|     480.30581 |     1.001 |    -1.252 |   -0.9149 |   -0.8991 |
-#> |.....................|   -0.8479 |   -0.5266 |   -0.9741 |    -1.001 |
-#> |.....................|   -0.6178 |   -0.7459 |   -0.6746 |...........|
-#> |    U|     480.30581 |     94.12 |    -5.652 |    -1.003 |   -0.2037 |
-#> |.....................|     2.101 |     1.866 |    0.6854 |    0.7536 |
-#> |.....................|     1.486 |     1.224 |     1.368 |...........|
-#> |    X|     480.30581 |     94.12 |  0.003510 |    0.2683 |    0.8157 |
-#> |.....................|     8.176 |     1.866 |    0.6854 |    0.7536 |
-#> |.....................|     1.486 |     1.224 |     1.368 |...........|
-#> |    F| Forward Diff. |    -5.315 |    0.7789 |   -0.2090 |  -0.03720 |
-#> |.....................|  -0.09944 |    -3.577 |     1.911 |   -0.6518 |
-#> |.....................|    -1.378 |    -1.528 |    -1.376 |...........|
-#> |   64|     480.30125 |     1.002 |    -1.254 |   -0.9146 |   -0.8990 |
-#> |.....................|   -0.8478 |   -0.5264 |   -0.9748 |    -1.001 |
-#> |.....................|   -0.6176 |   -0.7454 |   -0.6743 |...........|
-#> |    U|     480.30125 |     94.19 |    -5.654 |    -1.003 |   -0.2037 |
-#> |.....................|     2.101 |     1.866 |    0.6848 |    0.7538 |
-#> |.....................|     1.486 |     1.224 |     1.368 |...........|
-#> |    X|     480.30125 |     94.19 |  0.003505 |    0.2683 |    0.8157 |
-#> |.....................|     8.177 |     1.866 |    0.6848 |    0.7538 |
-#> |.....................|     1.486 |     1.224 |     1.368 |...........|
-#> |    F| Forward Diff. |     4.353 |    0.7723 |   -0.1834 |  -0.03622 |
-#> |.....................|  -0.07047 |    -3.672 |     1.822 |   -0.6713 |
-#> |.....................|    -1.445 |    -1.532 |    -1.389 |...........|
-#> |   65|     480.29714 |     1.001 |    -1.255 |   -0.9143 |   -0.8990 |
-#> |.....................|   -0.8476 |   -0.5261 |   -0.9754 |    -1.001 |
-#> |.....................|   -0.6174 |   -0.7450 |   -0.6740 |...........|
-#> |    U|     480.29714 |     94.12 |    -5.655 |    -1.003 |   -0.2036 |
-#> |.....................|     2.101 |     1.866 |    0.6843 |    0.7539 |
-#> |.....................|     1.487 |     1.225 |     1.369 |...........|
-#> |    X|     480.29714 |     94.12 |  0.003499 |    0.2684 |    0.8158 |
-#> |.....................|     8.178 |     1.866 |    0.6843 |    0.7539 |
-#> |.....................|     1.487 |     1.225 |     1.369 |...........|
-#> |    F| Forward Diff. |    -5.435 |    0.7663 |   -0.1878 |  -0.03986 |
-#> |.....................|   -0.1019 |    -3.343 |     1.893 |    0.6711 |
-#> |.....................|    -1.269 |    -1.487 |    -1.354 |...........|
-#> |   66|     480.29215 |     1.002 |    -1.257 |   -0.9143 |   -0.8989 |
-#> |.....................|   -0.8476 |   -0.5260 |   -0.9760 |    -1.001 |
-#> |.....................|   -0.6172 |   -0.7444 |   -0.6736 |...........|
-#> |    U|     480.29215 |     94.18 |    -5.657 |    -1.003 |   -0.2036 |
-#> |.....................|     2.102 |     1.867 |    0.6839 |    0.7538 |
-#> |.....................|     1.487 |     1.226 |     1.369 |...........|
-#> |    X|     480.29215 |     94.18 |  0.003493 |    0.2684 |    0.8158 |
-#> |.....................|     8.179 |     1.867 |    0.6839 |    0.7538 |
-#> |.....................|     1.487 |     1.226 |     1.369 |...........|
-#> |    F| Forward Diff. |     4.161 |    0.7621 |   -0.1686 |  -0.03452 |
-#> |.....................|  -0.06632 |    -3.552 |     1.775 |    0.6057 |
-#> |.....................|    -1.379 |    -1.473 |    -1.364 |...........|
-#> |   67|     480.28721 |     1.001 |    -1.259 |   -0.9145 |   -0.8989 |
-#> |.....................|   -0.8476 |   -0.5257 |   -0.9765 |    -1.001 |
-#> |.....................|   -0.6170 |   -0.7439 |   -0.6732 |...........|
-#> |    U|     480.28721 |     94.12 |    -5.659 |    -1.003 |   -0.2035 |
-#> |.....................|     2.102 |     1.867 |    0.6836 |    0.7537 |
-#> |.....................|     1.487 |     1.226 |     1.369 |...........|
-#> |    X|     480.28721 |     94.12 |  0.003487 |    0.2684 |    0.8159 |
-#> |.....................|     8.179 |     1.867 |    0.6836 |    0.7537 |
-#> |.....................|     1.487 |     1.226 |     1.369 |...........|
-#> |    F| Forward Diff. |    -4.925 |    0.7584 |   -0.1913 |  -0.03513 |
-#> |.....................|  -0.09132 |    -3.418 |     1.781 |   -0.6203 |
-#> |.....................|    -1.349 |    -1.417 |    -1.313 |...........|
-#> |   68|     480.28278 |     1.002 |    -1.260 |   -0.9144 |   -0.8988 |
-#> |.....................|   -0.8475 |   -0.5255 |   -0.9770 |    -1.001 |
-#> |.....................|   -0.6167 |   -0.7434 |   -0.6728 |...........|
-#> |    U|     480.28278 |     94.19 |    -5.660 |    -1.003 |   -0.2035 |
-#> |.....................|     2.102 |     1.867 |    0.6832 |    0.7537 |
-#> |.....................|     1.487 |     1.227 |     1.370 |...........|
-#> |    X|     480.28278 |     94.19 |  0.003481 |    0.2684 |    0.8159 |
-#> |.....................|     8.179 |     1.867 |    0.6832 |    0.7537 |
-#> |.....................|     1.487 |     1.227 |     1.370 |...........|
-#> |    F| Forward Diff. |     4.442 |    0.7524 |   -0.1734 |  -0.03276 |
-#> |.....................|  -0.06267 |    -3.400 |     1.746 |   -0.5960 |
-#> |.....................|    -1.307 |    -1.411 |    -1.323 |...........|
-#> |   69|     480.27897 |     1.001 |    -1.262 |   -0.9141 |   -0.8988 |
-#> |.....................|   -0.8474 |   -0.5252 |   -0.9776 |    -1.001 |
-#> |.....................|   -0.6165 |   -0.7431 |   -0.6724 |...........|
-#> |    U|     480.27897 |     94.13 |    -5.662 |    -1.003 |   -0.2034 |
-#> |.....................|     2.102 |     1.867 |    0.6827 |    0.7539 |
-#> |.....................|     1.488 |     1.227 |     1.370 |...........|
-#> |    X|     480.27897 |     94.13 |  0.003475 |    0.2684 |    0.8159 |
-#> |.....................|     8.180 |     1.867 |    0.6827 |    0.7539 |
-#> |.....................|     1.488 |     1.227 |     1.370 |...........|
-#> |    F| Forward Diff. |    -4.732 |    0.7463 |   -0.1764 |  -0.03625 |
-#> |.....................|  -0.08933 |    -3.375 |     1.716 |    0.6486 |
-#> |.....................|    -1.273 |    -1.374 |    -1.283 |...........|
-#> |   70|     480.27440 |     1.002 |    -1.264 |   -0.9140 |   -0.8987 |
-#> |.....................|   -0.8473 |   -0.5250 |   -0.9782 |    -1.001 |
-#> |.....................|   -0.6164 |   -0.7427 |   -0.6721 |...........|
-#> |    U|      480.2744 |     94.19 |    -5.664 |    -1.003 |   -0.2034 |
-#> |.....................|     2.102 |     1.867 |    0.6823 |    0.7538 |
-#> |.....................|     1.488 |     1.227 |     1.371 |...........|
-#> |    X|      480.2744 |     94.19 |  0.003469 |    0.2684 |    0.8160 |
-#> |.....................|     8.181 |     1.867 |    0.6823 |    0.7538 |
-#> |.....................|     1.488 |     1.227 |     1.371 |...........|
-#> |    F| Forward Diff. |     4.305 |    0.7431 |   -0.1535 |  -0.02884 |
-#> |.....................|  -0.05624 |    -3.424 |     1.641 |   -0.6166 |
-#> |.....................|    -1.366 |    -1.368 |    -1.291 |...........|
-#> |   71|     480.27043 |     1.001 |    -1.266 |   -0.9140 |   -0.8987 |
-#> |.....................|   -0.8473 |   -0.5247 |   -0.9786 |    -1.001 |
-#> |.....................|   -0.6161 |   -0.7423 |   -0.6718 |...........|
-#> |    U|     480.27043 |     94.13 |    -5.666 |    -1.002 |   -0.2033 |
-#> |.....................|     2.102 |     1.868 |    0.6819 |    0.7539 |
-#> |.....................|     1.488 |     1.228 |     1.371 |...........|
-#> |    X|     480.27043 |     94.13 |  0.003463 |    0.2685 |    0.8160 |
-#> |.....................|     8.181 |     1.868 |    0.6819 |    0.7539 |
-#> |.....................|     1.488 |     1.228 |     1.371 |...........|
-#> |    F| Forward Diff. |    -4.306 |    0.7372 |   -0.1665 |  -0.03186 |
-#> |.....................|  -0.08221 |    -3.333 |     1.631 |   -0.6040 |
-#> |.....................|    -1.265 |    -1.322 |    -1.255 |...........|
-#> |   72|     480.26665 |     1.002 |    -1.267 |   -0.9136 |   -0.8986 |
-#> |.....................|   -0.8471 |   -0.5244 |   -0.9791 |    -1.001 |
-#> |.....................|   -0.6160 |   -0.7419 |   -0.6714 |...........|
-#> |    U|     480.26665 |     94.19 |    -5.667 |    -1.002 |   -0.2032 |
-#> |.....................|     2.102 |     1.868 |    0.6815 |    0.7540 |
-#> |.....................|     1.488 |     1.228 |     1.371 |...........|
-#> |    X|     480.26665 |     94.19 |  0.003457 |    0.2685 |    0.8161 |
-#> |.....................|     8.182 |     1.868 |    0.6815 |    0.7540 |
-#> |.....................|     1.488 |     1.228 |     1.371 |...........|
-#> |    F| Forward Diff. |     4.654 |    0.7327 |   -0.1326 |  -0.02617 |
-#> |.....................|  -0.04981 |    -3.394 |     1.559 |   -0.6139 |
-#> |.....................|    -1.358 |    -1.341 |    -1.268 |...........|
-#> |   73|     480.26300 |     1.001 |    -1.269 |   -0.9132 |   -0.8985 |
-#> |.....................|   -0.8470 |   -0.5241 |   -0.9796 |    -1.000 |
-#> |.....................|   -0.6158 |   -0.7416 |   -0.6711 |...........|
-#> |    U|       480.263 |     94.13 |    -5.669 |    -1.002 |   -0.2032 |
-#> |.....................|     2.102 |     1.868 |    0.6812 |    0.7542 |
-#> |.....................|     1.488 |     1.229 |     1.372 |...........|
-#> |    X|       480.263 |     94.13 |  0.003451 |    0.2686 |    0.8162 |
-#> |.....................|     8.183 |     1.868 |    0.6812 |    0.7542 |
-#> |.....................|     1.488 |     1.229 |     1.372 |...........|
-#> |    F| Forward Diff. |    -4.009 |    0.7258 |   -0.1343 |  -0.03035 |
-#> |.....................|  -0.07619 |    -3.164 |     1.609 |   -0.5397 |
-#> |.....................|    -1.251 |    -1.282 |    -1.219 |...........|
-#> |   74|     480.25930 |     1.002 |    -1.271 |   -0.9130 |   -0.8985 |
-#> |.....................|   -0.8469 |   -0.5239 |   -0.9802 |    -1.000 |
-#> |.....................|   -0.6155 |   -0.7412 |   -0.6708 |...........|
-#> |    U|      480.2593 |     94.19 |    -5.671 |    -1.002 |   -0.2031 |
-#> |.....................|     2.102 |     1.868 |    0.6807 |    0.7543 |
-#> |.....................|     1.489 |     1.229 |     1.372 |...........|
-#> |    X|      480.2593 |     94.19 |  0.003445 |    0.2686 |    0.8162 |
-#> |.....................|     8.184 |     1.868 |    0.6807 |    0.7543 |
-#> |.....................|     1.489 |     1.229 |     1.372 |...........|
-#> |    F| Forward Diff. |     4.851 |    0.7223 |   -0.1045 |  -0.02290 |
-#> |.....................|  -0.04316 |    -3.376 |     1.478 |    0.6193 |
-#> |.....................|    -1.343 |    -1.302 |    -1.232 |...........|
-#> |   75|     480.25486 |     1.001 |    -1.273 |   -0.9131 |   -0.8984 |
-#> |.....................|   -0.8469 |   -0.5237 |   -0.9805 |    -1.000 |
-#> |.....................|   -0.6152 |   -0.7408 |   -0.6705 |...........|
-#> |    U|     480.25486 |     94.14 |    -5.673 |    -1.002 |   -0.2030 |
-#> |.....................|     2.102 |     1.868 |    0.6805 |    0.7542 |
-#> |.....................|     1.489 |     1.230 |     1.373 |...........|
-#> |    X|     480.25486 |     94.14 |  0.003439 |    0.2686 |    0.8162 |
-#> |.....................|     8.184 |     1.868 |    0.6805 |    0.7542 |
-#> |.....................|     1.489 |     1.230 |     1.373 |...........|
-#> |    F| Forward Diff. |    -3.282 |    0.7167 |   -0.1236 |  -0.02586 |
-#> |.....................|  -0.06793 |    -3.294 |     1.470 |    0.6693 |
-#> |.....................|    -1.247 |    -1.242 |    -1.194 |...........|
-#> |   76|     480.25000 |     1.002 |    -1.274 |   -0.9134 |   -0.8984 |
-#> |.....................|   -0.8469 |   -0.5231 |   -0.9806 |    -1.001 |
-#> |.....................|   -0.6147 |   -0.7402 |   -0.6701 |...........|
-#> |    U|        480.25 |     94.20 |    -5.674 |    -1.002 |   -0.2030 |
-#> |.....................|     2.102 |     1.869 |    0.6804 |    0.7539 |
-#> |.....................|     1.490 |     1.230 |     1.373 |...........|
-#> |    X|        480.25 |     94.20 |  0.003434 |    0.2686 |    0.8163 |
-#> |.....................|     8.184 |     1.869 |    0.6804 |    0.7539 |
-#> |.....................|     1.490 |     1.230 |     1.373 |...........|
-#> |    F| Forward Diff. |     5.823 |    0.7134 |   -0.1173 |  -0.02040 |
-#> |.....................|  -0.04062 |    -3.151 |     1.491 |   -0.5685 |
-#> |.....................|    -1.243 |    -1.237 |    -1.210 |...........|
-#> |   77|     480.24598 |     1.001 |    -1.276 |   -0.9134 |   -0.8984 |
-#> |.....................|   -0.8469 |   -0.5229 |   -0.9809 |    -1.001 |
-#> |.....................|   -0.6145 |   -0.7399 |   -0.6698 |...........|
-#> |    U|     480.24598 |     94.13 |    -5.676 |    -1.002 |   -0.2030 |
-#> |.....................|     2.102 |     1.869 |    0.6802 |    0.7539 |
-#> |.....................|     1.490 |     1.231 |     1.373 |...........|
-#> |    X|     480.24598 |     94.13 |  0.003427 |    0.2686 |    0.8163 |
-#> |.....................|     8.184 |     1.869 |    0.6802 |    0.7539 |
-#> |.....................|     1.490 |     1.231 |     1.373 |...........|
-#> |    F| Forward Diff. |    -3.294 |    0.7076 |   -0.1362 |  -0.02383 |
-#> |.....................|  -0.06566 |    -3.147 |     1.461 |    0.6663 |
-#> |.....................|    -1.244 |    -1.185 |    -1.155 |...........|
-#> |   78|     480.24152 |     1.002 |    -1.278 |   -0.9134 |   -0.8983 |
-#> |.....................|   -0.8469 |   -0.5225 |   -0.9813 |    -1.001 |
-#> |.....................|   -0.6142 |   -0.7395 |   -0.6694 |...........|
-#> |    U|     480.24152 |     94.19 |    -5.678 |    -1.002 |   -0.2030 |
-#> |.....................|     2.102 |     1.869 |    0.6799 |    0.7538 |
-#> |.....................|     1.490 |     1.231 |     1.374 |...........|
-#> |    X|     480.24152 |     94.19 |  0.003421 |    0.2686 |    0.8163 |
-#> |.....................|     8.184 |     1.869 |    0.6799 |    0.7538 |
-#> |.....................|     1.490 |     1.231 |     1.374 |...........|
-#> |    F| Forward Diff. |     4.573 |    0.7031 |   -0.1214 |  -0.01999 |
-#> |.....................|  -0.04022 |    -3.129 |     1.425 |    0.6287 |
-#> |.....................|    -1.274 |    -1.197 |    -1.174 |...........|
-#> |   79|     480.23703 |     1.001 |    -1.280 |   -0.9136 |   -0.8983 |
-#> |.....................|   -0.8469 |   -0.5223 |   -0.9815 |    -1.001 |
-#> |.....................|   -0.6136 |   -0.7392 |   -0.6691 |...........|
-#> |    U|     480.23703 |     94.13 |    -5.680 |    -1.002 |   -0.2030 |
-#> |.....................|     2.102 |     1.869 |    0.6797 |    0.7536 |
-#> |.....................|     1.491 |     1.231 |     1.374 |...........|
-#> |    X|     480.23703 |     94.13 |  0.003415 |    0.2685 |    0.8163 |
-#> |.....................|     8.184 |     1.869 |    0.6797 |    0.7536 |
-#> |.....................|     1.491 |     1.231 |     1.374 |...........|
-#> |    F| Forward Diff. |    -3.496 |    0.6977 |   -0.1464 |  -0.02500 |
-#> |.....................|  -0.06997 |    -3.031 |     1.316 |    0.6455 |
-#> |.....................|    -1.198 |    -1.144 |    -1.124 |...........|
-#> |   80|     480.23246 |     1.002 |    -1.281 |   -0.9138 |   -0.8983 |
-#> |.....................|   -0.8469 |   -0.5219 |   -0.9816 |    -1.001 |
-#> |.....................|   -0.6131 |   -0.7387 |   -0.6687 |...........|
-#> |    U|     480.23246 |     94.19 |    -5.681 |    -1.002 |   -0.2030 |
-#> |.....................|     2.102 |     1.870 |    0.6796 |    0.7533 |
-#> |.....................|     1.492 |     1.232 |     1.375 |...........|
-#> |    X|     480.23246 |     94.19 |  0.003409 |    0.2685 |    0.8163 |
-#> |.....................|     8.184 |     1.870 |    0.6796 |    0.7533 |
-#> |.....................|     1.492 |     1.232 |     1.375 |...........|
-#> |    F| Forward Diff. |     4.825 |    0.6940 |   -0.1347 |  -0.01919 |
-#> |.....................|  -0.03939 |    -3.118 |     1.378 |    0.5922 |
-#> |.....................|    -1.219 |    -1.136 |    -1.127 |...........|
-#> |   81|     480.22809 |     1.001 |    -1.283 |   -0.9138 |   -0.8983 |
-#> |.....................|   -0.8469 |   -0.5217 |   -0.9816 |    -1.002 |
-#> |.....................|   -0.6127 |   -0.7384 |   -0.6684 |...........|
-#> |    U|     480.22809 |     94.14 |    -5.683 |    -1.002 |   -0.2029 |
-#> |.....................|     2.102 |     1.870 |    0.6796 |    0.7531 |
-#> |.....................|     1.492 |     1.232 |     1.375 |...........|
-#> |    X|     480.22809 |     94.14 |  0.003403 |    0.2685 |    0.8163 |
-#> |.....................|     8.184 |     1.870 |    0.6796 |    0.7531 |
-#> |.....................|     1.492 |     1.232 |     1.375 |...........|
-#> |    F| Forward Diff. |    -3.001 |    0.6885 |   -0.1518 |  -0.02256 |
-#> |.....................|  -0.06414 |    -2.892 |     1.443 |    0.6415 |
-#> |.....................|    -1.085 |    -1.098 |    -1.101 |...........|
-#> |   82|     480.22387 |     1.002 |    -1.285 |   -0.9139 |   -0.8983 |
-#> |.....................|   -0.8469 |   -0.5212 |   -0.9821 |    -1.002 |
-#> |.....................|   -0.6124 |   -0.7381 |   -0.6680 |...........|
-#> |    U|     480.22387 |     94.19 |    -5.685 |    -1.002 |   -0.2029 |
-#> |.....................|     2.102 |     1.870 |    0.6793 |    0.7529 |
-#> |.....................|     1.492 |     1.232 |     1.375 |...........|
-#> |    X|     480.22387 |     94.19 |  0.003397 |    0.2685 |    0.8163 |
-#> |.....................|     8.184 |     1.870 |    0.6793 |    0.7529 |
-#> |.....................|     1.492 |     1.232 |     1.375 |...........|
-#> |    F| Forward Diff. |     5.360 |    0.6846 |   -0.1392 |  -0.01938 |
-#> |.....................|  -0.04006 |    -2.853 |     1.421 |   -0.5715 |
-#> |.....................|    -1.064 |    -1.117 |    -1.118 |...........|
-#> |   83|     480.22054 |     1.001 |    -1.287 |   -0.9139 |   -0.8983 |
-#> |.....................|   -0.8469 |   -0.5210 |   -0.9826 |    -1.002 |
-#> |.....................|   -0.6125 |   -0.7380 |   -0.6676 |...........|
-#> |    U|     480.22054 |     94.14 |    -5.687 |    -1.002 |   -0.2029 |
-#> |.....................|     2.102 |     1.871 |    0.6789 |    0.7530 |
-#> |.....................|     1.492 |     1.233 |     1.376 |...........|
-#> |    X|     480.22054 |     94.14 |  0.003391 |    0.2685 |    0.8163 |
-#> |.....................|     8.184 |     1.871 |    0.6789 |    0.7530 |
-#> |.....................|     1.492 |     1.233 |     1.376 |...........|
-#> |    F| Forward Diff. |    -2.774 |    0.6781 |   -0.1521 |  -0.02419 |
-#> |.....................|  -0.06697 |    -2.800 |     1.392 |    0.6467 |
-#> |.....................|    -1.111 |    -1.074 |    -1.064 |...........|
-#> |   84|     480.21670 |     1.002 |    -1.288 |   -0.9138 |   -0.8983 |
-#> |.....................|   -0.8469 |   -0.5206 |   -0.9832 |    -1.002 |
-#> |.....................|   -0.6123 |   -0.7378 |   -0.6672 |...........|
-#> |    U|      480.2167 |     94.19 |    -5.688 |    -1.002 |   -0.2029 |
-#> |.....................|     2.102 |     1.871 |    0.6784 |    0.7529 |
-#> |.....................|     1.493 |     1.233 |     1.376 |...........|
-#> |    X|      480.2167 |     94.19 |  0.003385 |    0.2685 |    0.8163 |
-#> |.....................|     8.184 |     1.871 |    0.6784 |    0.7529 |
-#> |.....................|     1.493 |     1.233 |     1.376 |...........|
-#> |    F| Forward Diff. |     4.519 |    0.6730 |   -0.1351 |  -0.02088 |
-#> |.....................|  -0.04118 |    -2.856 |     1.311 |    0.6094 |
-#> |.....................|    -1.165 |    -1.062 |    -1.048 |...........|
-#> |   85|     480.21269 |     1.001 |    -1.290 |   -0.9139 |   -0.8983 |
-#> |.....................|   -0.8469 |   -0.5205 |   -0.9835 |    -1.002 |
-#> |.....................|   -0.6119 |   -0.7376 |   -0.6670 |...........|
-#> |    U|     480.21269 |     94.14 |    -5.690 |    -1.002 |   -0.2029 |
-#> |.....................|     2.102 |     1.871 |    0.6782 |    0.7527 |
-#> |.....................|     1.493 |     1.233 |     1.377 |...........|
-#> |    X|     480.21269 |     94.14 |  0.003379 |    0.2685 |    0.8163 |
-#> |.....................|     8.184 |     1.871 |    0.6782 |    0.7527 |
-#> |.....................|     1.493 |     1.233 |     1.377 |...........|
-#> |    F| Forward Diff. |    -2.933 |    0.6686 |   -0.1517 |  -0.01805 |
-#> |.....................|  -0.06304 |    -2.806 |     1.298 |    0.6045 |
-#> |.....................|    -1.073 |    -1.045 |    -1.026 |...........|
-#> |   86|     480.20865 |     1.002 |    -1.292 |   -0.9139 |   -0.8983 |
-#> |.....................|   -0.8469 |   -0.5201 |   -0.9839 |    -1.002 |
-#> |.....................|   -0.6115 |   -0.7373 |   -0.6667 |...........|
-#> |    U|     480.20865 |     94.19 |    -5.692 |    -1.002 |   -0.2029 |
-#> |.....................|     2.102 |     1.871 |    0.6779 |    0.7525 |
-#> |.....................|     1.494 |     1.233 |     1.377 |...........|
-#> |    X|     480.20865 |     94.19 |  0.003373 |    0.2685 |    0.8163 |
-#> |.....................|     8.184 |     1.871 |    0.6779 |    0.7525 |
-#> |.....................|     1.494 |     1.233 |     1.377 |...........|
-#> |    F| Forward Diff. |     4.802 |    0.6647 |   -0.1367 |  -0.01906 |
-#> |.....................|  -0.03994 |    -2.699 |     1.311 |   -0.5807 |
-#> |.....................|    -1.078 |    -1.030 |    -1.030 |...........|
-#> |   87|     480.20558 |     1.001 |    -1.294 |   -0.9137 |   -0.8983 |
-#> |.....................|   -0.8468 |   -0.5199 |   -0.9842 |    -1.002 |
-#> |.....................|   -0.6113 |   -0.7372 |   -0.6665 |...........|
-#> |    U|     480.20558 |     94.14 |    -5.694 |    -1.002 |   -0.2029 |
-#> |.....................|     2.102 |     1.871 |    0.6776 |    0.7525 |
-#> |.....................|     1.494 |     1.233 |     1.377 |...........|
-#> |    X|     480.20558 |     94.14 |  0.003367 |    0.2685 |    0.8163 |
-#> |.....................|     8.185 |     1.871 |    0.6776 |    0.7525 |
-#> |.....................|     1.494 |     1.233 |     1.377 |...........|
-#> |    F| Forward Diff. |    -2.911 |    0.6576 |   -0.1438 |  -0.02051 |
-#> |.....................|  -0.06613 |    -2.751 |     1.246 |   -0.6218 |
-#> |.....................|    -1.053 |    -1.017 |    -1.010 |...........|
-#> |   88|     480.20291 |     1.002 |    -1.296 |   -0.9132 |   -0.8982 |
-#> |.....................|   -0.8467 |   -0.5195 |   -0.9848 |    -1.002 |
-#> |.....................|   -0.6112 |   -0.7370 |   -0.6662 |...........|
-#> |    U|     480.20291 |     94.19 |    -5.696 |    -1.002 |   -0.2029 |
-#> |.....................|     2.102 |     1.872 |    0.6772 |    0.7527 |
-#> |.....................|     1.494 |     1.234 |     1.377 |...........|
-#> |    X|     480.20291 |     94.19 |  0.003361 |    0.2686 |    0.8164 |
-#> |.....................|     8.186 |     1.872 |    0.6772 |    0.7527 |
-#> |.....................|     1.494 |     1.234 |     1.377 |...........|
-#> |    F| Forward Diff. |     4.296 |    0.6533 |   -0.1055 |  -0.01383 |
-#> |.....................|  -0.03435 |    -2.750 |     1.192 |   -0.6155 |
-#> |.....................|    -1.121 |    -1.037 |    -1.054 |...........|
-#> |   89|     480.20010 |     1.001 |    -1.297 |   -0.9127 |   -0.8982 |
-#> |.....................|   -0.8466 |   -0.5193 |   -0.9850 |    -1.002 |
-#> |.....................|   -0.6110 |   -0.7368 |   -0.6658 |...........|
-#> |    U|      480.2001 |     94.14 |    -5.697 |    -1.001 |   -0.2028 |
-#> |.....................|     2.103 |     1.872 |    0.6771 |    0.7528 |
-#> |.....................|     1.494 |     1.234 |     1.378 |...........|
-#> |    X|      480.2001 |     94.14 |  0.003355 |    0.2687 |    0.8164 |
-#> |.....................|     8.187 |     1.872 |    0.6771 |    0.7528 |
-#> |.....................|     1.494 |     1.234 |     1.378 |...........|
-#> |    F| Forward Diff. |    -2.841 |    0.6461 |  -0.09617 |  -0.01892 |
-#> |.....................|  -0.05600 |    -2.503 |     1.255 |    0.6797 |
-#> |.....................|   -0.9587 |    -1.006 |   -0.9794 |...........|
-#> |   90|     480.19652 |     1.002 |    -1.299 |   -0.9127 |   -0.8982 |
-#> |.....................|   -0.8466 |   -0.5191 |   -0.9853 |    -1.002 |
-#> |.....................|   -0.6108 |   -0.7364 |   -0.6653 |...........|
-#> |    U|     480.19652 |     94.19 |    -5.699 |    -1.001 |   -0.2028 |
-#> |.....................|     2.103 |     1.872 |    0.6768 |    0.7526 |
-#> |.....................|     1.494 |     1.234 |     1.378 |...........|
-#> |    X|     480.19652 |     94.19 |  0.003349 |    0.2687 |    0.8164 |
-#> |.....................|     8.187 |     1.872 |    0.6768 |    0.7526 |
-#> |.....................|     1.494 |     1.234 |     1.378 |...........|
-#> |   91|     480.19461 |     1.002 |    -1.301 |   -0.9128 |   -0.8982 |
-#> |.....................|   -0.8466 |   -0.5193 |   -0.9855 |    -1.002 |
-#> |.....................|   -0.6107 |   -0.7361 |   -0.6650 |...........|
-#> |    U|     480.19461 |     94.18 |    -5.701 |    -1.001 |   -0.2028 |
-#> |.....................|     2.103 |     1.872 |    0.6767 |    0.7526 |
-#> |.....................|     1.494 |     1.235 |     1.379 |...........|
-#> |    X|     480.19461 |     94.18 |  0.003342 |    0.2687 |    0.8164 |
-#> |.....................|     8.187 |     1.872 |    0.6767 |    0.7526 |
-#> |.....................|     1.494 |     1.235 |     1.379 |...........|
-#> |   92|     480.18441 |     1.002 |    -1.313 |   -0.9134 |   -0.8983 |
-#> |.....................|   -0.8466 |   -0.5209 |   -0.9862 |    -1.003 |
-#> |.....................|   -0.6104 |   -0.7344 |   -0.6628 |...........|
-#> |    U|     480.18441 |     94.17 |    -5.713 |    -1.002 |   -0.2029 |
-#> |.....................|     2.103 |     1.871 |    0.6762 |    0.7522 |
-#> |.....................|     1.495 |     1.237 |     1.381 |...........|
-#> |    X|     480.18441 |     94.17 |  0.003303 |    0.2686 |    0.8164 |
-#> |.....................|     8.187 |     1.871 |    0.6762 |    0.7522 |
-#> |.....................|     1.495 |     1.237 |     1.381 |...........|
-#> |   93|     480.15712 |     1.001 |    -1.360 |   -0.9157 |   -0.8984 |
-#> |.....................|   -0.8466 |   -0.5271 |   -0.9890 |    -1.004 |
-#> |.....................|   -0.6089 |   -0.7277 |   -0.6540 |...........|
-#> |    U|     480.15712 |     94.12 |    -5.760 |    -1.004 |   -0.2031 |
-#> |.....................|     2.103 |     1.866 |    0.6740 |    0.7509 |
-#> |.....................|     1.497 |     1.244 |     1.391 |...........|
-#> |    X|     480.15712 |     94.12 |  0.003151 |    0.2681 |    0.8162 |
-#> |.....................|     8.187 |     1.866 |    0.6740 |    0.7509 |
-#> |.....................|     1.497 |     1.244 |     1.391 |...........|
-#> |   94|     480.23418 |    0.9997 |    -1.543 |   -0.9246 |   -0.8991 |
-#> |.....................|   -0.8465 |   -0.5509 |    -1.000 |    -1.011 |
-#> |.....................|   -0.6032 |   -0.7017 |   -0.6198 |...........|
-#> |    U|     480.23418 |     93.97 |    -5.943 |    -1.013 |   -0.2037 |
-#> |.....................|     2.103 |     1.847 |    0.6655 |    0.7454 |
-#> |.....................|     1.503 |     1.272 |     1.431 |...........|
-#> |    X|     480.23418 |     93.97 |  0.002624 |    0.2664 |    0.8157 |
-#> |.....................|     8.187 |     1.847 |    0.6655 |    0.7454 |
-#> |.....................|     1.503 |     1.272 |     1.431 |...........|
-#> |    F| Forward Diff. |    -6.048 |    0.4781 |   -0.2230 |  -0.02217 |
-#> |.....................|  -0.05480 |    -3.577 |    0.9301 |    0.6494 |
-#> |.....................|    -1.028 |   -0.4525 |   -0.4232 |...........|
-#> |   95|     480.10748 |     1.002 |    -1.612 |   -0.8919 |   -0.8955 |
-#> |.....................|   -0.8419 |   -0.5057 |    -1.005 |    -1.011 |
-#> |.....................|   -0.6089 |   -0.7402 |   -0.6757 |...........|
-#> |    U|     480.10748 |     94.20 |    -6.012 |   -0.9804 |   -0.2001 |
-#> |.....................|     2.107 |     1.883 |    0.6618 |    0.7449 |
-#> |.....................|     1.497 |     1.230 |     1.367 |...........|
-#> |    X|     480.10748 |     94.20 |  0.002450 |    0.2728 |    0.8186 |
-#> |.....................|     8.225 |     1.883 |    0.6618 |    0.7449 |
-#> |.....................|     1.497 |     1.230 |     1.367 |...........|
-#> |    F| Forward Diff. |     5.588 |   -0.2032 |     1.050 |   0.05863 |
-#> |.....................|    0.1556 |    -1.013 |   -0.1797 |    0.1430 |
-#> |.....................|    -1.088 |    -1.192 |    -1.504 |...........|
-#> |   96|     480.44664 |     1.003 |    -1.804 |   -0.9880 |   -0.8940 |
-#> |.....................|   -0.8524 |   -0.4601 |   -0.9127 |    -1.040 |
-#> |.....................|   -0.5485 |   -0.7099 |   -0.6226 |...........|
-#> |    U|     480.44664 |     94.31 |    -6.204 |    -1.077 |   -0.1987 |
-#> |.....................|     2.097 |     1.919 |    0.7320 |    0.7196 |
-#> |.....................|     1.568 |     1.263 |     1.427 |...........|
-#> |    X|     480.44664 |     94.31 |  0.002022 |    0.2542 |    0.8198 |
-#> |.....................|     8.139 |     1.919 |    0.7320 |    0.7196 |
-#> |.....................|     1.568 |     1.263 |     1.427 |...........|
-#> |   97|     480.05051 |     1.002 |    -1.657 |   -0.9147 |   -0.8952 |
-#> |.....................|   -0.8444 |   -0.4949 |   -0.9832 |    -1.018 |
-#> |.....................|   -0.5946 |   -0.7329 |   -0.6630 |...........|
-#> |    U|     480.05051 |     94.19 |    -6.057 |    -1.003 |   -0.1998 |
-#> |.....................|     2.105 |     1.891 |    0.6784 |    0.7389 |
-#> |.....................|     1.514 |     1.238 |     1.381 |...........|
-#> |    X|     480.05051 |     94.19 |  0.002341 |    0.2683 |    0.8189 |
-#> |.....................|     8.205 |     1.891 |    0.6784 |    0.7389 |
-#> |.....................|     1.514 |     1.238 |     1.381 |...........|
-#> |    F| Forward Diff. |     3.048 |   -0.2764 |  -0.02525 |   0.07726 |
-#> |.....................|    0.1002 |    0.1555 |     1.072 |    0.1458 |
-#> |.....................|   -0.5013 |   -0.7465 |   -0.9442 |...........|
-#> |   98|     480.05873 |     1.002 |    -1.641 |   -0.9145 |   -0.9051 |
-#> |.....................|   -0.8597 |   -0.5017 |   -0.9961 |    -1.019 |
-#> |.....................|   -0.5552 |   -0.7600 |   -0.6392 |...........|
-#> |    U|     480.05873 |     94.21 |    -6.041 |    -1.003 |   -0.2097 |
-#> |.....................|     2.089 |     1.886 |    0.6686 |    0.7381 |
-#> |.....................|     1.561 |     1.209 |     1.408 |...........|
-#> |    X|     480.05873 |     94.21 |  0.002380 |    0.2684 |    0.8108 |
-#> |.....................|     8.080 |     1.886 |    0.6686 |    0.7381 |
-#> |.....................|     1.561 |     1.209 |     1.408 |...........|
-#> |   99|     480.03299 |     1.002 |    -1.650 |   -0.9146 |   -0.8993 |
-#> |.....................|   -0.8508 |   -0.4977 |   -0.9887 |    -1.018 |
-#> |.....................|   -0.5780 |   -0.7442 |   -0.6529 |...........|
-#> |    U|     480.03299 |     94.17 |    -6.050 |    -1.003 |   -0.2040 |
-#> |.....................|     2.098 |     1.889 |    0.6742 |    0.7386 |
-#> |.....................|     1.533 |     1.226 |     1.393 |...........|
-#> |    X|     480.03299 |     94.17 |  0.002357 |    0.2683 |    0.8155 |
-#> |.....................|     8.152 |     1.889 |    0.6742 |    0.7386 |
-#> |.....................|     1.533 |     1.226 |     1.393 |...........|
-#> |    F| Forward Diff. |  -0.07884 |   -0.2508 |  -0.03233 |  -0.02314 |
-#> |.....................|   -0.1302 |   0.06288 |    0.7629 |    0.2261 |
-#> |.....................|    0.3850 |    -1.277 |   -0.6610 |...........|
-#> |  100|     480.00970 |     1.003 |    -1.641 |   -0.9125 |   -0.9005 |
-#> |.....................|   -0.8500 |   -0.4980 |   -0.9983 |    -1.021 |
-#> |.....................|   -0.5841 |   -0.7275 |   -0.6414 |...........|
-#> |    U|      480.0097 |     94.26 |    -6.041 |    -1.001 |   -0.2051 |
-#> |.....................|     2.099 |     1.889 |    0.6670 |    0.7367 |
-#> |.....................|     1.526 |     1.244 |     1.406 |...........|
-#> |    X|      480.0097 |     94.26 |  0.002380 |    0.2687 |    0.8145 |
-#> |.....................|     8.159 |     1.889 |    0.6670 |    0.7367 |
-#> |.....................|     1.526 |     1.244 |     1.406 |...........|
-#> |    F| Forward Diff. |     12.51 |   -0.2151 |    0.1066 |  -0.04414 |
-#> |.....................|  -0.06212 |   -0.2557 |   0.09002 |  -0.09728 |
-#> |.....................|   0.06582 |   -0.3883 |   0.07016 |...........|
-#> |  101|     480.02569 |     1.000 |    -1.627 |   -0.9257 |   -0.9015 |
-#> |.....................|   -0.8496 |   -0.4974 |    -1.010 |    -1.023 |
-#> |.....................|   -0.5876 |   -0.7200 |   -0.6493 |...........|
-#> |    U|     480.02569 |     94.03 |    -6.027 |    -1.014 |   -0.2061 |
-#> |.....................|     2.099 |     1.889 |    0.6581 |    0.7348 |
-#> |.....................|     1.522 |     1.252 |     1.397 |...........|
-#> |    X|     480.02569 |     94.03 |  0.002413 |    0.2662 |    0.8138 |
-#> |.....................|     8.162 |     1.889 |    0.6581 |    0.7348 |
-#> |.....................|     1.522 |     1.252 |     1.397 |...........|
-#> |  102|     480.01783 |     1.000 |    -1.636 |   -0.9171 |   -0.9008 |
-#> |.....................|   -0.8499 |   -0.4978 |    -1.002 |    -1.021 |
-#> |.....................|   -0.5853 |   -0.7249 |   -0.6441 |...........|
-#> |    U|     480.01783 |     94.03 |    -6.036 |    -1.006 |   -0.2055 |
-#> |.....................|     2.099 |     1.889 |    0.6639 |    0.7361 |
-#> |.....................|     1.525 |     1.247 |     1.403 |...........|
-#> |    X|     480.01783 |     94.03 |  0.002392 |    0.2678 |    0.8143 |
-#> |.....................|     8.160 |     1.889 |    0.6639 |    0.7361 |
-#> |.....................|     1.525 |     1.247 |     1.403 |...........|
-#> |  103|     480.01762 |     1.000 |    -1.639 |   -0.9140 |   -0.9006 |
-#> |.....................|   -0.8500 |   -0.4979 |   -0.9995 |    -1.021 |
-#> |.....................|   -0.5844 |   -0.7266 |   -0.6422 |...........|
-#> |    U|     480.01762 |     94.04 |    -6.039 |    -1.002 |   -0.2052 |
-#> |.....................|     2.099 |     1.889 |    0.6660 |    0.7365 |
-#> |.....................|     1.526 |     1.245 |     1.405 |...........|
-#> |    X|     480.01762 |     94.04 |  0.002384 |    0.2685 |    0.8145 |
-#> |.....................|     8.159 |     1.889 |    0.6660 |    0.7365 |
-#> |.....................|     1.526 |     1.245 |     1.405 |...........|
-#> |  104|     480.00603 |     1.001 |    -1.641 |   -0.9125 |   -0.9005 |
-#> |.....................|   -0.8500 |   -0.4980 |   -0.9983 |    -1.021 |
-#> |.....................|   -0.5841 |   -0.7275 |   -0.6414 |...........|
-#> |    U|     480.00603 |     94.12 |    -6.041 |    -1.001 |   -0.2051 |
-#> |.....................|     2.099 |     1.889 |    0.6670 |    0.7367 |
-#> |.....................|     1.526 |     1.244 |     1.406 |...........|
-#> |    X|     480.00603 |     94.12 |  0.002380 |    0.2687 |    0.8145 |
-#> |.....................|     8.159 |     1.889 |    0.6670 |    0.7367 |
-#> |.....................|     1.526 |     1.244 |     1.406 |...........|
-#> |    F| Forward Diff. |    -6.885 |   -0.2187 |   0.06031 |  -0.05864 |
-#> |.....................|   -0.1316 |   -0.6942 |  -0.07940 |    0.7419 |
-#> |.....................|   -0.2628 |   -0.6303 |   -0.1748 |...........|
-#> |  105|     480.00355 |     1.002 |    -1.640 |   -0.9125 |   -0.9004 |
-#> |.....................|   -0.8497 |   -0.4981 |   -0.9983 |    -1.021 |
-#> |.....................|   -0.5835 |   -0.7267 |   -0.6420 |...........|
-#> |    U|     480.00355 |     94.17 |    -6.040 |    -1.001 |   -0.2050 |
-#> |.....................|     2.099 |     1.889 |    0.6669 |    0.7366 |
-#> |.....................|     1.527 |     1.245 |     1.405 |...........|
-#> |    X|     480.00355 |     94.17 |  0.002382 |    0.2687 |    0.8147 |
-#> |.....................|     8.162 |     1.889 |    0.6669 |    0.7366 |
-#> |.....................|     1.527 |     1.245 |     1.405 |...........|
-#> |    F| Forward Diff. |   -0.1332 |   -0.2152 |   0.07761 |  -0.04946 |
-#> |.....................|  -0.09731 |  -0.07704 |    0.1258 |    0.9492 |
-#> |.....................|   0.08309 |   -0.3432 |   0.03979 |...........|
-#> |  106|     480.00003 |     1.002 |    -1.640 |   -0.9126 |   -0.9003 |
-#> |.....................|   -0.8495 |   -0.4980 |   -0.9985 |    -1.022 |
-#> |.....................|   -0.5836 |   -0.7262 |   -0.6420 |...........|
-#> |    U|     480.00003 |     94.19 |    -6.040 |    -1.001 |   -0.2049 |
-#> |.....................|     2.100 |     1.889 |    0.6668 |    0.7355 |
-#> |.....................|     1.527 |     1.245 |     1.405 |...........|
-#> |    X|     480.00003 |     94.19 |  0.002382 |    0.2687 |    0.8147 |
-#> |.....................|     8.163 |     1.889 |    0.6668 |    0.7355 |
-#> |.....................|     1.527 |     1.245 |     1.405 |...........|
-#> |    F| Forward Diff. |     2.294 |   -0.2073 |   0.08146 |  -0.04541 |
-#> |.....................|  -0.07807 |   -0.2293 |   0.05730 |    0.8075 |
-#> |.....................| -0.008164 |   -0.3171 |   0.03808 |...........|
-#> |  107|     479.99578 |     1.002 |    -1.638 |   -0.9109 |   -0.8997 |
-#> |.....................|   -0.8483 |   -0.4984 |   -0.9975 |    -1.023 |
-#> |.....................|   -0.5809 |   -0.7230 |   -0.6440 |...........|
-#> |    U|     479.99578 |     94.17 |    -6.038 |   -0.9994 |   -0.2043 |
-#> |.....................|     2.101 |     1.889 |    0.6675 |    0.7343 |
-#> |.....................|     1.530 |     1.249 |     1.403 |...........|
-#> |    X|     479.99578 |     94.17 |  0.002387 |    0.2691 |    0.8152 |
-#> |.....................|     8.172 |     1.889 |    0.6675 |    0.7343 |
-#> |.....................|     1.530 |     1.249 |     1.403 |...........|
-#> |  108|     479.99301 |     1.002 |    -1.632 |   -0.9055 |   -0.8980 |
-#> |.....................|   -0.8447 |   -0.4999 |   -0.9947 |    -1.027 |
-#> |.....................|   -0.5728 |   -0.7134 |   -0.6498 |...........|
-#> |    U|     479.99301 |     94.16 |    -6.032 |   -0.9941 |   -0.2026 |
-#> |.....................|     2.104 |     1.887 |    0.6697 |    0.7310 |
-#> |.....................|     1.540 |     1.259 |     1.396 |...........|
-#> |    X|     479.99301 |     94.16 |  0.002402 |    0.2701 |    0.8166 |
-#> |.....................|     8.202 |     1.887 |    0.6697 |    0.7310 |
-#> |.....................|     1.540 |     1.259 |     1.396 |...........|
-#> |    F| Forward Diff. |   -0.5972 |   -0.1625 |    0.4650 |  0.009686 |
-#> |.....................|   0.08636 |    -1.694 |   -0.1652 |    -1.042 |
-#> |.....................|   -0.1517 |    0.4204 |   -0.3659 |...........|
-#> |  109|     479.98697 |     1.002 |    -1.611 |   -0.9101 |   -0.8945 |
-#> |.....................|   -0.8385 |   -0.4966 |   -0.9980 |    -1.027 |
-#> |.....................|   -0.5750 |   -0.7140 |   -0.6459 |...........|
-#> |    U|     479.98697 |     94.17 |    -6.011 |   -0.9986 |   -0.1991 |
-#> |.....................|     2.111 |     1.890 |    0.6672 |    0.7309 |
-#> |.....................|     1.537 |     1.259 |     1.401 |...........|
-#> |    X|     479.98697 |     94.17 |  0.002451 |    0.2692 |    0.8195 |
-#> |.....................|     8.253 |     1.890 |    0.6672 |    0.7309 |
-#> |.....................|     1.537 |     1.259 |     1.401 |...........|
-#> |    F| Forward Diff. | -0.005684 |   -0.1115 |    0.2082 |   0.08938 |
-#> |.....................|    0.3008 |   0.01411 |    0.1052 |   -0.7061 |
-#> |.....................|    0.4111 |    0.4010 |   -0.1199 |...........|
-#> |  110|     479.98697 |     1.002 |    -1.611 |   -0.9101 |   -0.8945 |
-#> |.....................|   -0.8385 |   -0.4966 |   -0.9980 |    -1.027 |
-#> |.....................|   -0.5750 |   -0.7140 |   -0.6459 |...........|
-#> |    U|     479.98697 |     94.17 |    -6.011 |   -0.9986 |   -0.1991 |
-#> |.....................|     2.111 |     1.890 |    0.6672 |    0.7309 |
-#> |.....................|     1.537 |     1.259 |     1.401 |...........|
-#> |    X|     479.98697 |     94.17 |  0.002451 |    0.2692 |    0.8195 |
-#> |.....................|     8.253 |     1.890 |    0.6672 |    0.7309 |
-#> |.....................|     1.537 |     1.259 |     1.401 |...........|
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-f_nlmixr_dfop_sfo_focei_const <- nlmixr(f_mmkin_const["DFOP-SFO", ], est = "focei")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
-#> F: Forward difference gradient approximation
-#> C: Central difference gradient approximation
-#> M: Mixed forward and central difference gradient approximation
-#> Unscaled parameters for Omegas=chol(solve(omega));
-#> Diagonals are transformed, as specified by foceiControl(diagXform=)
-#> |-----+---------------+-----------+-----------+-----------+-----------|
-#> |    #| Objective Fun |  parent_0 |  log_k_A1 |f_parent_qlogis |    log_k1 |
-#> |.....................|    log_k2 |  g_qlogis |     sigma |        o1 |
-#> |.....................|        o2 |        o3 |        o4 |        o5 |
-#> |.....................|        o6 |...........|...........|...........|
-#> |    1|     517.20934 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     517.20934 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     517.20934 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    G|    Gill Diff. |     64.43 |     1.648 |  -0.07882 |   -0.2050 |
-#> |.....................|   -0.4304 |   0.05992 |    -56.51 |     17.73 |
-#> |.....................|     9.983 |    -11.00 |    -3.771 |     3.593 |
-#> |.....................|    -10.58 |...........|...........|...........|
-#> |    2|     2737.3115 |    0.2806 |    -1.018 |   -0.9100 |   -0.9273 |
-#> |.....................|   -0.9731 |   -0.8892 |   -0.2282 |    -1.075 |
-#> |.....................|   -0.9854 |   -0.7447 |   -0.8291 |   -0.9136 |
-#> |.....................|   -0.7499 |...........|...........|...........|
-#> |    U|     2737.3115 |     26.38 |    -5.418 |   -0.9691 |    -1.898 |
-#> |.....................|    -4.295 |    0.1399 |     2.105 |    0.5864 |
-#> |.....................|    0.7671 |     1.329 |     1.042 |    0.8535 |
-#> |.....................|     1.298 |...........|...........|...........|
-#> |    X|     2737.3115 |     26.38 |  0.004434 |    0.2751 |    0.1499 |
-#> |.....................|   0.01363 |    0.5349 |     2.105 |    0.5864 |
-#> |.....................|    0.7671 |     1.329 |     1.042 |    0.8535 |
-#> |.....................|     1.298 |...........|...........|...........|
-#> |    3|     569.57476 |    0.9281 |    -1.002 |   -0.9108 |   -0.9293 |
-#> |.....................|   -0.9774 |   -0.8886 |   -0.7961 |   -0.8964 |
-#> |.....................|   -0.8851 |   -0.8553 |   -0.8670 |   -0.8775 |
-#> |.....................|   -0.8562 |...........|...........|...........|
-#> |    U|     569.57476 |     87.24 |    -5.402 |   -0.9699 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.650 |    0.7166 |
-#> |.....................|    0.8537 |     1.198 |     1.004 |    0.8856 |
-#> |.....................|     1.175 |...........|...........|...........|
-#> |    X|     569.57476 |     87.24 |  0.004508 |    0.2749 |    0.1496 |
-#> |.....................|   0.01358 |    0.5349 |     1.650 |    0.7166 |
-#> |.....................|    0.8537 |     1.198 |     1.004 |    0.8856 |
-#> |.....................|     1.175 |...........|...........|...........|
-#> |    4|     531.41065 |    0.9928 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9778 |   -0.8885 |   -0.8528 |   -0.8786 |
-#> |.....................|   -0.8751 |   -0.8663 |   -0.8708 |   -0.8739 |
-#> |.....................|   -0.8668 |...........|...........|...........|
-#> |    U|     531.41065 |     93.32 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.605 |    0.7297 |
-#> |.....................|    0.8624 |     1.185 |     1.000 |    0.8888 |
-#> |.....................|     1.163 |...........|...........|...........|
-#> |    X|     531.41065 |     93.32 |  0.004516 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.605 |    0.7297 |
-#> |.....................|    0.8624 |     1.185 |     1.000 |    0.8888 |
-#> |.....................|     1.163 |...........|...........|...........|
-#> |    5|     531.74000 |    0.9993 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8585 |   -0.8768 |
-#> |.....................|   -0.8741 |   -0.8674 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8679 |...........|...........|...........|
-#> |    U|        531.74 |     93.93 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.601 |    0.7310 |
-#> |.....................|    0.8632 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|        531.74 |     93.93 |  0.004516 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.601 |    0.7310 |
-#> |.....................|    0.8632 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    6|     531.81753 |    0.9999 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8591 |   -0.8767 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.81753 |     93.99 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.81753 |     93.99 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    7|     531.82573 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8591 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82573 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82573 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    8|     531.82668 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82668 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82668 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    9|     531.82678 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82678 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82678 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |   10|     531.82679 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82679 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82679 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |   11|     531.82679 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82679 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82679 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |   12|     531.82678 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82678 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82678 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |   13|     531.82679 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82679 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82679 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |   14|     531.82679 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82679 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82679 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |   15|     531.82679 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82679 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82679 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |   16|     531.82679 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82679 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82679 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |   17|     531.82679 |     1.000 |    -1.000 |   -0.9109 |   -0.9296 |
-#> |.....................|   -0.9779 |   -0.8885 |   -0.8592 |   -0.8766 |
-#> |.....................|   -0.8740 |   -0.8675 |   -0.8712 |   -0.8735 |
-#> |.....................|   -0.8680 |...........|...........|...........|
-#> |    U|     531.82679 |     94.00 |    -5.400 |   -0.9700 |    -1.900 |
-#> |.....................|    -4.300 |    0.1400 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> |    X|     531.82679 |     94.00 |  0.004517 |    0.2749 |    0.1496 |
-#> |.....................|   0.01357 |    0.5349 |     1.600 |    0.7311 |
-#> |.....................|    0.8633 |     1.183 |     1.000 |    0.8891 |
-#> |.....................|     1.161 |...........|...........|...........|
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-
-# Variance by variable is supported by 'saem' and 'focei'
-f_nlmixr_fomc_sfo_saem_obs <- nlmixr(f_mmkin_obs["FOMC-SFO", ], est = "saem")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#>  
-#> → generate SAEM model
-#> ✔ done
-#> 1:    93.4067   -5.7935   -0.0604    2.2993   -1.1624    2.9450    1.7342    0.6650    0.5890    0.4750   14.5215    9.1023
-#> 2:    93.8811   -5.7873   -0.0289    2.3640   -1.0762    2.7977    2.0710    0.6317    0.5595    0.4512   11.1033    4.6425
-#> 3:    94.0397   -5.9934    0.0119    2.4035   -1.0703    3.0693    2.4524    0.6124    0.5316    0.4287   10.0698    3.4243
-#> 4:    93.8834   -6.0401    0.0041    2.3944   -1.0097    2.9159    3.1645    0.6120    0.5050    0.4073    9.2013    3.2162
-#> 5:    94.0163   -5.8381   -0.0267    2.3580   -1.0239    2.7701    3.0063    0.5814    0.4797    0.3869    9.0330    3.0330
-#> 6:    93.9753   -5.8371   -0.0315    2.3598   -1.0052    2.6316    2.8559    0.5708    0.4558    0.3675    8.6051    2.6518
-#> 7:    93.6109   -5.8741   -0.0401    2.3570   -1.0025    2.5000    2.7131    0.5691    0.4330    0.3492    8.4407    2.4701
-#> 8:    93.2480   -6.0361   -0.0523    2.3504   -1.0028    2.3750    3.1584    0.5407    0.4113    0.3317    8.6121    2.2437
-#> 9:    93.2245   -6.0431   -0.0503    2.3552   -0.9828    2.2562    3.9790    0.5395    0.3908    0.3151    8.6609    2.1129
-#> 10:    93.3040   -6.1080   -0.0503    2.3613   -0.9784    2.1434    4.8606    0.5401    0.3712    0.2994    8.6497    2.0865
-#> 11:    93.4509   -5.9532   -0.0503    2.3444   -0.9823    3.0948    4.6176    0.5679    0.3527    0.2844    8.1651    2.0310
-#> 12:    93.5099   -6.1699   -0.0503    2.3408   -0.9746    3.2814    4.3867    0.5679    0.3350    0.2702    8.1716    1.9862
-#> 13:    93.8052   -6.1984   -0.0474    2.3233   -0.9922    3.1173    4.6967    0.5644    0.3183    0.2567    8.2982    2.0040
-#> 14:    93.6510   -6.0090   -0.0429    2.3601   -0.9885    2.9615    4.4618    0.5526    0.3024    0.2438    8.3254    2.0605
-#> 15:    93.8952   -6.3354   -0.0394    2.3580   -0.9792    2.8134    5.2117    0.5657    0.2872    0.2316    8.1329    2.0520
-#> 16:    93.4703   -6.0722   -0.0434    2.3386   -1.0026    2.6727    4.9512    0.5781    0.2729    0.2201    8.0866    2.0994
-#> 17:    93.4238   -6.2132   -0.0755    2.3120   -1.0119    2.5391    4.7036    0.5495    0.2592    0.2091    7.5958    2.2864
-#> 18:    93.5288   -6.2747   -0.0616    2.3223   -1.0105    2.4121    4.4684    0.5467    0.2463    0.1986    7.1910    1.9828
-#> 19:    93.2607   -6.3635   -0.0631    2.3206   -1.0045    3.6271    4.8142    0.5405    0.2340    0.1928    7.3672    1.8187
-#> 20:    93.3918   -6.3241   -0.0742    2.2941   -1.0140    3.4457    4.9242    0.5596    0.2223    0.1950    7.1427    1.8754
-#> 21:    93.6794   -6.1336   -0.0758    2.3000   -1.0048    3.2734    4.6780    0.5565    0.2111    0.1852    7.0989    1.9232
-#> 22:    94.0006   -6.1882   -0.0800    2.3099   -1.0252    3.1098    4.4441    0.5354    0.2006    0.1870    7.0038    1.9920
-#> 23:    93.6433   -6.2626   -0.0841    2.2791   -1.0183    4.8893    4.4476    0.5276    0.1906    0.1798    6.3698    1.8787
-#> 24:    93.9545   -6.3772   -0.0816    2.2887   -1.0019    4.6448    5.1698    0.5293    0.1810    0.1779    6.5903    1.9474
-#> 25:    94.2280   -6.3235   -0.0839    2.2600   -0.9932    5.2801    4.9113    0.5262    0.1720    0.1806    6.5267    1.9807
-#> 26:    94.2022   -6.2830   -0.0883    2.2643   -1.0012    5.9595    4.6658    0.5225    0.1634    0.1795    6.3678    1.9659
-#> 27:    94.4398   -6.1769   -0.0894    2.2564   -1.0177    9.0771    4.4325    0.5207    0.1552    0.1880    6.4522    1.8590
-#> 28:    94.2586   -6.1652   -0.0882    2.2574   -1.0226    8.6233    4.2108    0.5158    0.1475    0.1881    6.3701    1.7882
-#> 29:    94.3490   -6.1505   -0.0854    2.2615   -1.0081    9.6333    4.0003    0.5109    0.1423    0.1833    6.3601    1.8485
-#> 30:    94.6929   -6.0285   -0.0909    2.2610   -1.0082    9.1517    3.8003    0.5117    0.1401    0.2097    6.2461    1.8606
-#> 31:    94.2553   -6.0390   -0.0896    2.2625   -1.0078    8.6941    3.6103    0.5072    0.1378    0.2088    6.3337    1.8220
-#> 32:    94.3096   -5.7252   -0.0886    2.2677   -0.9967    9.0244    3.4298    0.5051    0.1325    0.2015    6.4601    1.8880
-#> 33:    94.8327   -5.8775   -0.0865    2.2684   -0.9976    8.6305    3.2583    0.4920    0.1333    0.1993    6.4804    1.8203
-#> 34:    94.3527   -5.9488   -0.0826    2.2879   -0.9989    8.1989    3.1538    0.4969    0.1388    0.1984    6.4201    1.7696
-#> 35:    94.4411   -6.1171   -0.0826    2.2913   -0.9964    8.4377    3.7937    0.4969    0.1387    0.1972    6.3878    1.7612
-#> 36:    94.2058   -6.1151   -0.0844    2.2920   -1.0069    8.0158    3.7963    0.4962    0.1395    0.1938    6.2469    1.6680
-#> 37:    93.7449   -6.1251   -0.0925    2.2736   -1.0019    7.6150    3.8477    0.5101    0.1325    0.1841    6.1375    1.7472
-#> 38:    93.6861   -6.0575   -0.0934    2.2803   -1.0097    7.2343    3.6553    0.5119    0.1259    0.1862    6.0729    1.7608
-#> 39:    93.9767   -6.0314   -0.0999    2.2548   -1.0231    6.8726    3.4725    0.5195    0.1234    0.1951    6.1947    1.8276
-#> 40:    94.0297   -6.1559   -0.0989    2.2440   -1.0374    6.5290    3.8559    0.5199    0.1279    0.1891    6.0195    1.8906
-#> 41:    94.2069   -6.3055   -0.0820    2.2710   -1.0275    6.2025    4.7866    0.5304    0.1215    0.1858    6.1777    1.8541
-#> 42:    94.2400   -6.3179   -0.0790    2.2783   -1.0379    5.8924    4.6915    0.5253    0.1154    0.1794    6.0530    1.8960
-#> 43:    93.9851   -6.4096   -0.0784    2.2832   -1.0341    5.5978    5.0608    0.5163    0.1097    0.1773    6.0057    1.8136
-#> 44:    94.1440   -6.2214   -0.0746    2.2969   -1.0262    5.3179    4.8077    0.5130    0.1079    0.1851    6.1182    1.8390
-#> 45:    93.8847   -6.3883   -0.0745    2.3059   -1.0132    6.8202    5.1378    0.5130    0.1174    0.1769    6.1000    1.8391
-#> 46:    93.7228   -6.3305   -0.0794    2.3033   -1.0107    6.4792    4.8809    0.5095    0.1196    0.1783    6.2794    1.7304
-#> 47:    93.7031   -6.4232   -0.0796    2.3006   -1.0028    6.1552    5.5756    0.5092    0.1243    0.1887    6.1716    1.7279
-#> 48:    93.5210   -6.2770   -0.0794    2.2948   -1.0122    5.8475    5.2968    0.5098    0.1247    0.1863    5.9847    1.7994
-#> 49:    93.3676   -6.4486   -0.0754    2.3079   -1.0061    5.5551    5.4356    0.5018    0.1198    0.1858    6.1108    1.7598
-#> 50:    93.8573   -6.3944   -0.0755    2.3057   -1.0038    5.2773    5.2487    0.5063    0.1193    0.1843    6.0935    1.7725
-#> 51:    93.7004   -6.2783   -0.0854    2.2836   -1.0074    5.0135    4.9863    0.4932    0.1269    0.1858    6.1630    1.8063
-#> 52:    93.4843   -6.3763   -0.0962    2.2731   -1.0073    4.7628    5.0969    0.4815    0.1345    0.1924    6.0823    1.8013
-#> 53:    93.6971   -6.5002   -0.0887    2.2774   -1.0111    4.5246    5.7428    0.4726    0.1346    0.1982    6.1744    1.7695
-#> 54:    93.6176   -6.4928   -0.0917    2.2648   -1.0220    4.2984    5.4557    0.4765    0.1419    0.2017    6.3732    1.8195
-#> 55:    93.7072   -6.5760   -0.0833    2.2865   -1.0282    4.0835    5.9775    0.4732    0.1434    0.1963    6.3653    1.7028
-#> 56:    94.1360   -6.6854   -0.0901    2.2941   -1.0244    3.8793    7.2562    0.4637    0.1393    0.1935    6.3001    1.7878
-#> 57:    93.4627   -6.6255   -0.1049    2.2502   -1.0233    3.6854    6.8934    0.4847    0.1323    0.1878    6.2357    1.8480
-#> 58:    93.8066   -6.6603   -0.1049    2.2362   -1.0280    3.5011    6.9334    0.4847    0.1397    0.1872    6.3582    1.7787
-#> 59:    93.8599   -6.7837   -0.1046    2.2450   -1.0274    3.3260    8.4672    0.4853    0.1332    0.1833    6.1248    1.8066
-#> 60:    93.6190   -6.5618   -0.1055    2.2381   -1.0244    3.1597    8.0438    0.4742    0.1390    0.1858    6.2589    1.7881
-#> 61:    93.7045   -6.6482   -0.1159    2.2413   -1.0272    3.2942    7.8485    0.4655    0.1406    0.1827    5.8425    1.7744
-#> 62:    93.5232   -6.5027   -0.1168    2.2418   -1.0187    3.3810    7.4560    0.4766    0.1414    0.1790    5.9349    1.7717
-#> 63:    93.4884   -6.4221   -0.1164    2.2505   -1.0062    3.2119    7.0832    0.4768    0.1422    0.1752    6.0193    1.7434
-#> 64:    93.2305   -6.4456   -0.1153    2.2573   -1.0062    4.1468    6.7291    0.4776    0.1395    0.1753    5.8355    1.7529
-#> 65:    93.3743   -6.3237   -0.1227    2.2484   -1.0102    3.9395    6.3926    0.4864    0.1374    0.1800    5.6731    1.7808
-#> 66:    93.7132   -6.3178   -0.1186    2.2389   -0.9894    4.0557    6.0730    0.4909    0.1426    0.1807    5.7099    1.7283
-#> 67:    93.7490   -6.3514   -0.1155    2.2445   -0.9946    3.8529    5.7693    0.4938    0.1379    0.1830    5.7366    1.7847
-#> 68:    93.7617   -6.1181   -0.1251    2.2487   -0.9841    3.7650    5.4809    0.4816    0.1549    0.1769    5.6569    1.7415
-#> 69:    93.4342   -6.3588   -0.1301    2.2350   -0.9813    4.5688    5.2068    0.4745    0.1624    0.1736    5.5771    1.7091
-#> 70:    93.5303   -6.3266   -0.1330    2.2384   -0.9753    4.3404    4.9465    0.4734    0.1563    0.1699    5.5332    1.7256
-#> 71:    93.4733   -6.2859   -0.1364    2.2170   -0.9781    4.1234    4.6992    0.4701    0.1604    0.1649    5.6661    1.7335
-#> 72:    93.3055   -6.2502   -0.1462    2.2156   -0.9724    3.9172    4.7693    0.4519    0.1607    0.1582    5.4776    1.7679
-#> 73:    93.3010   -6.6844   -0.1490    2.2262   -0.9777    3.7213    6.9975    0.4426    0.1848    0.1640    5.7066    1.7588
-#> 74:    93.1104   -6.6720   -0.1484    2.2079   -0.9982    3.5353    6.7811    0.4436    0.1807    0.1732    5.7700    1.7343
-#> 75:    93.4534   -6.9644   -0.1480    2.2078   -0.9930    3.3585    8.7027    0.4497    0.1717    0.1708    5.5371    1.7098
-#> 76:    93.5886   -6.3503   -0.1491    2.1958   -0.9884    3.7136    8.2676    0.4509    0.1731    0.1706    5.3943    1.7340
-#> 77:    93.4345   -6.4976   -0.1531    2.1831   -0.9928    4.5945    7.8542    0.4592    0.1741    0.1703    5.5564    1.7164
-#> 78:    93.6007   -6.4885   -0.1538    2.1850   -0.9919    4.3647    7.4615    0.4607    0.1803    0.1692    5.4698    1.7354
-#> 79:    93.2897   -7.0329   -0.1518    2.1935   -0.9863    4.6922   10.9870    0.4569    0.1790    0.1608    5.3799    1.7484
-#> 80:    93.4130   -6.6634   -0.1531    2.1865   -0.9839    5.4720   10.4377    0.4585    0.1852    0.1543    5.4298    1.7237
-#> 81:    93.5828   -6.7204   -0.1563    2.1914   -0.9882    5.1984    9.9158    0.4548    0.1973    0.1600    5.4425    1.7741
-#> 82:    93.4450   -6.7357   -0.1537    2.1964   -0.9958    4.9384   10.1331    0.4577    0.1874    0.1632    5.6874    1.7789
-#> 83:    93.6109   -6.9249   -0.1493    2.2061   -0.9945    4.6915   11.1537    0.4474    0.1781    0.1686    5.4249    1.7317
-#> 84:    93.7133   -6.8029   -0.1493    2.2016   -0.9886    4.4569   10.9568    0.4474    0.1715    0.1689    5.5426    1.7227
-#> 85:    93.8040   -6.6434   -0.1483    2.2032   -0.9861    5.4991   10.4090    0.4330    0.1749    0.1726    5.4570    1.7332
-#> 86:    93.9029   -6.7750   -0.1472    2.2066   -0.9892    5.2241   11.7325    0.4352    0.1819    0.1644    5.5652    1.6802
-#> 87:    93.8127   -6.7015   -0.1499    2.2019   -0.9891    4.9629   11.1459    0.4292    0.1977    0.1661    5.7122    1.6713
-#> 88:    93.6777   -6.7044   -0.1440    2.2074   -1.0050    4.7148   10.5886    0.4379    0.1878    0.1750    5.6084    1.7096
-#> 89:    94.0481   -6.2990   -0.1443    2.2085   -0.9869    4.4790   10.0591    0.4355    0.1951    0.1688    5.4280    1.8093
-#> 90:    93.6399   -6.3965   -0.1429    2.2138   -0.9737    5.1306    9.5562    0.4367    0.1917    0.1604    5.5652    1.7458
-#> 91:    93.8670   -6.3075   -0.1426    2.2128   -0.9856    5.1368    9.0784    0.4427    0.1993    0.1546    5.3927    1.8246
-#> 92:    93.7332   -6.4793   -0.1426    2.2091   -0.9835    5.0102    8.6245    0.4427    0.1986    0.1585    5.4463    1.7343
-#> 93:    93.8211   -6.3270   -0.1416    2.2123   -0.9941    4.7597    8.1932    0.4431    0.1908    0.1689    5.5213    1.7093
-#> 94:    93.7499   -6.0880   -0.1390    2.2158   -0.9960    5.1992    7.7836    0.4444    0.1958    0.1733    5.5329    1.7880
-#> 95:    93.6253   -6.2196   -0.1436    2.2126   -1.0053    4.9392    7.3944    0.4383    0.2011    0.1717    5.6042    1.7460
-#> 96:    93.8862   -6.1475   -0.1408    2.2211   -0.9922    4.6923    7.0247    0.4347    0.2077    0.1669    5.6807    1.6943
-#> 97:    93.7610   -6.2409   -0.1368    2.2281   -0.9864    4.4576    6.6734    0.4313    0.2084    0.1723    5.5387    1.7075
-#> 98:    93.5362   -6.3378   -0.1368    2.2294   -0.9813    4.2348    6.3398    0.4313    0.2127    0.1877    5.5850    1.6627
-#> 99:    93.5044   -6.2557   -0.1311    2.2282   -0.9993    4.0230    6.0228    0.4461    0.2167    0.1879    5.6437    1.7076
-#> 100:    93.3102   -6.3602   -0.1311    2.2368   -1.0040    3.8219    5.7216    0.4461    0.2139    0.1875    5.8029    1.7592
-#> 101:    93.4687   -6.0385   -0.1241    2.2347   -1.0031    3.6308    5.4356    0.4483    0.2035    0.1816    6.0097    1.7002
-#> 102:    93.6536   -6.2867   -0.1299    2.2421   -1.0002    3.4492    5.1743    0.4434    0.1993    0.1872    5.8540    1.7162
-#> 103:    93.9532   -6.2261   -0.1277    2.2361   -0.9931    3.2768    5.0546    0.4450    0.2069    0.1884    5.6688    1.7324
-#> 104:    93.9839   -6.1980   -0.1287    2.2286   -1.0081    3.1129    5.0671    0.4475    0.1997    0.1985    5.7690    1.7636
-#> 105:    94.1682   -6.1671   -0.1283    2.2217   -1.0154    2.9573    4.8137    0.4481    0.1976    0.1965    5.9277    1.7386
-#> 106:    94.2778   -6.1839   -0.1243    2.2323   -1.0022    3.5381    4.5730    0.4707    0.1980    0.1932    5.7059    1.7184
-#> 107:    94.3667   -5.9941   -0.1182    2.2283   -1.0191    3.3612    4.3444    0.4753    0.1984    0.1986    5.7813    1.7446
-#> 108:    94.2722   -6.1869   -0.1171    2.2293   -1.0027    3.6659    4.6329    0.4742    0.1986    0.2011    5.7827    1.7074
-#> 109:    94.1997   -6.2385   -0.1172    2.2241   -1.0083    3.4826    4.7954    0.4721    0.2027    0.2020    5.8339    1.7650
-#> 110:    94.3017   -6.3774   -0.1291    2.2229   -0.9857    3.7634    5.8516    0.4810    0.2126    0.1984    5.7961    1.6706
-#> 111:    93.9803   -6.0240   -0.1258    2.2273   -0.9879    3.5752    5.5590    0.4749    0.2060    0.1976    5.6243    1.7082
-#> 112:    94.1307   -6.0036   -0.1253    2.2365   -0.9886    4.0368    5.2810    0.4760    0.2060    0.1975    5.5732    1.7063
-#> 113:    93.8676   -6.2496   -0.1118    2.2600   -1.0080    3.8350    5.0170    0.4855    0.2109    0.2006    5.6406    1.7357
-#> 114:    93.5949   -6.3200   -0.1044    2.2449   -1.0172    3.6472    4.7661    0.4868    0.2095    0.2131    5.7690    1.7428
-#> 115:    93.6997   -6.3282   -0.1046    2.2567   -1.0135    3.4648    4.8622    0.4876    0.2264    0.2134    5.8853    1.7823
-#> 116:    93.8191   -6.0802   -0.1087    2.2535   -1.0011    3.4347    4.6191    0.4786    0.2176    0.2108    5.6553    1.7802
-#> 117:    93.8575   -6.0930   -0.1022    2.2498   -0.9898    3.3071    4.3881    0.4822    0.2163    0.2075    5.7806    1.8150
-#> 118:    93.9164   -5.9787   -0.1133    2.2535   -0.9861    4.2578    4.1687    0.4687    0.2198    0.2088    5.4441    1.8411
-#> 119:    93.8748   -6.0108   -0.1165    2.2488   -0.9775    4.0449    3.9603    0.4653    0.2271    0.2032    5.6119    1.7501
-#> 120:    93.6001   -6.0447   -0.1144    2.2477   -0.9821    3.8426    3.7623    0.4641    0.2223    0.2055    5.6454    1.7244
-#> 121:    93.6712   -5.9851   -0.1195    2.2484   -0.9917    3.6505    3.5742    0.4600    0.2143    0.2010    5.4083    1.7965
-#> 122:    93.6859   -6.0390   -0.1145    2.2497   -0.9888    3.4680    3.5595    0.4618    0.2136    0.1986    5.4111    1.7519
-#> 123:    93.6014   -5.8383   -0.1145    2.2584   -0.9893    3.6047    3.3815    0.4618    0.2155    0.2045    5.3624    1.7023
-#> 124:    93.6333   -5.7861   -0.1131    2.2556   -0.9872    3.4245    3.2125    0.4621    0.2153    0.2025    5.3930    1.7036
-#> 125:    93.4504   -5.9483   -0.1154    2.2531   -0.9924    3.2533    3.0518    0.4640    0.2175    0.2030    5.5097    1.6830
-#> 126:    93.5693   -5.8818   -0.1120    2.2506   -0.9960    3.0906    2.8992    0.4606    0.2267    0.2016    5.4583    1.6650
-#> 127:    93.7074   -5.8191   -0.1178    2.2412   -0.9891    2.9361    2.7543    0.4688    0.2234    0.2039    5.4861    1.8125
-#> 128:    93.5959   -5.8842   -0.1179    2.2544   -0.9985    3.0224    2.6166    0.4700    0.2237    0.2019    5.6417    1.8454
-#> 129:    93.5600   -5.8683   -0.1161    2.2365   -0.9987    3.4186    2.4857    0.4721    0.2182    0.1918    5.4391    1.8145
-#> 130:    93.4104   -5.8226   -0.1126    2.2355   -0.9892    3.3648    2.4231    0.4763    0.2212    0.1873    5.3999    1.7457
-#> 131:    93.5045   -5.7255   -0.1118    2.2486   -0.9918    4.1951    2.3020    0.4776    0.2121    0.1927    5.4342    1.7744
-#> 132:    93.2626   -5.8379   -0.1097    2.2510   -0.9933    3.9853    2.5572    0.4763    0.2114    0.1966    5.2979    1.7239
-#> 133:    93.4370   -5.9097   -0.1049    2.2578   -0.9939    4.2190    2.8246    0.4738    0.2036    0.2020    5.2853    1.6765
-#> 134:    93.8665   -5.9439   -0.1035    2.2654   -0.9832    4.0081    3.1228    0.4756    0.2102    0.1961    5.3467    1.7177
-#> 135:    93.6301   -5.8062   -0.1031    2.2702   -0.9737    3.9024    2.9667    0.4748    0.2101    0.2003    5.3053    1.6977
-#> 136:    93.7744   -5.9328   -0.1055    2.2685   -0.9764    3.7072    2.9952    0.4721    0.2096    0.1949    5.4319    1.6864
-#> 137:    93.6734   -5.9886   -0.1107    2.2517   -0.9732    3.8811    3.4962    0.4642    0.2204    0.1924    5.4294    1.6684
-#> 138:    93.7128   -5.9927   -0.1119    2.2517   -0.9775    3.6870    3.4543    0.4667    0.2204    0.1953    5.3912    1.7060
-#> 139:    93.6530   -6.1296   -0.1210    2.2456   -0.9929    3.5027    4.6472    0.4527    0.2296    0.1855    5.4953    1.7242
-#> 140:    93.9344   -6.2519   -0.1384    2.2304   -0.9970    3.6814    4.4707    0.4337    0.2182    0.1762    5.5643    1.7596
-#> 141:    93.7356   -6.2804   -0.1296    2.2549   -0.9921    3.9811    4.4876    0.4218    0.2361    0.1674    5.3531    1.7175
-#> 142:    93.7399   -6.0023   -0.1098    2.2611   -0.9815    3.7821    4.2632    0.4395    0.2421    0.1807    5.3139    1.7191
-#> 143:    93.4732   -6.0376   -0.1108    2.2689   -0.9734    3.5930    4.0500    0.4396    0.2541    0.1718    5.2930    1.6229
-#> 144:    93.4900   -5.9517   -0.1093    2.2876   -0.9675    3.4133    3.8475    0.4337    0.2542    0.1711    5.4258    1.5660
-#> 145:    93.4090   -5.9596   -0.1000    2.2942   -0.9756    3.2426    3.6551    0.4274    0.2422    0.1671    5.3539    1.6971
-#> 146:    93.4142   -5.9549   -0.0982    2.2846   -0.9704    3.0805    3.6092    0.4226    0.2339    0.1745    5.5092    1.6696
-#> 147:    93.4409   -6.0720   -0.0971    2.2942   -0.9891    2.9265    3.9922    0.4224    0.2373    0.1781    5.5599    1.6080
-#> 148:    93.4504   -6.2201   -0.0980    2.2855   -0.9832    2.7802    4.6985    0.4104    0.2464    0.1856    5.5016    1.5877
-#> 149:    93.4240   -6.2122   -0.1005    2.2728   -0.9881    3.7659    4.7755    0.4082    0.2642    0.1885    5.4942    1.5534
-#> 150:    93.5094   -6.1295   -0.1087    2.2717   -0.9941    3.5776    4.5367    0.4109    0.2611    0.1928    5.3468    1.5585
-#> 151:    93.4038   -6.2751   -0.1130    2.2643   -0.9892    3.3987    4.9866    0.4172    0.2638    0.1905    5.4955    1.6256
-#> 152:    93.5072   -6.3361   -0.1147    2.2627   -0.9988    2.3580    5.3824    0.4175    0.2656    0.1819    5.7685    1.6126
-#> 153:    93.3582   -6.2019   -0.1227    2.2526   -0.9929    2.5874    4.7052    0.4348    0.2621    0.1810    5.5149    1.6181
-#> 154:    93.1890   -6.3537   -0.1263    2.2446   -0.9871    2.4073    5.7070    0.4351    0.2586    0.1829    5.3136    1.6272
-#> 155:    93.1706   -6.4117   -0.1260    2.2484   -0.9845    2.3035    6.0004    0.4463    0.2586    0.1781    5.4260    1.6494
-#> 156:    93.3240   -6.3931   -0.1259    2.2469   -0.9824    2.5659    5.7375    0.4466    0.2781    0.1754    5.6202    1.6591
-#> 157:    93.3239   -6.1812   -0.1242    2.2541   -0.9743    1.6054    4.5906    0.4478    0.2657    0.1758    5.6806    1.6367
-#> 158:    93.3756   -6.2562   -0.1264    2.2706   -0.9888    1.5329    4.6790    0.4458    0.2532    0.1728    5.7756    1.6248
-#> 159:    93.3034   -6.3291   -0.1217    2.2524   -0.9954    1.7774    5.7204    0.4532    0.2642    0.1715    5.8189    1.6830
-#> 160:    93.4387   -6.5115   -0.1196    2.2488   -0.9846    2.2219    6.4960    0.4555    0.2728    0.1689    5.5273    1.6332
-#> 161:    93.7646   -6.3820   -0.1231    2.2520   -0.9837    2.8322    5.7269    0.4498    0.2712    0.1730    5.3659    1.5787
-#> 162:    93.6252   -6.4563   -0.1243    2.2472   -0.9867    2.8322    5.9119    0.4502    0.2671    0.1726    5.4519    1.5819
-#> 163:    93.6787   -6.6444   -0.1292    2.2366   -0.9899    2.0520    7.4835    0.4556    0.2705    0.1689    5.4095    1.5883
-#> 164:    93.7458   -6.9330   -0.1257    2.2430   -0.9872    1.7825    9.4340    0.4495    0.2701    0.1593    5.4517    1.6116
-#> 165:    93.7370   -6.9118   -0.1250    2.2421   -0.9832    1.9949   10.6549    0.4499    0.2685    0.1622    5.6272    1.6075
-#> 166:    94.0889   -6.8704   -0.1276    2.2409   -0.9872    1.5618   10.4435    0.4482    0.2608    0.1648    5.5891    1.6208
-#> 167:    94.1319   -7.2779   -0.1206    2.2505   -0.9894    1.5063   13.4312    0.4393    0.2549    0.1661    5.6013    1.6043
-#> 168:    93.8341   -6.9310   -0.1140    2.2495   -0.9844    1.7329   11.3224    0.4463    0.2540    0.1629    5.8366    1.6765
-#> 169:    93.8923   -6.6547   -0.1173    2.2620   -0.9872    1.4531    8.4608    0.4419    0.2414    0.1666    5.8784    1.6268
-#> 170:    94.0072   -6.3970   -0.1173    2.2606   -0.9861    1.4164    6.9237    0.4419    0.2468    0.1656    5.8793    1.6387
-#> 171:    93.8690   -6.5151   -0.1079    2.2482   -0.9880    1.9225    7.7681    0.4547    0.2404    0.1523    6.0158    1.6281
-#> 172:    93.6847   -6.3416   -0.1095    2.2438   -0.9849    2.0143    5.5739    0.4498    0.2450    0.1534    6.1355    1.6422
-#> 173:    93.4817   -6.3165   -0.1115    2.2573   -0.9885    1.6855    5.5626    0.4440    0.2471    0.1542    6.1343    1.6337
-#> 174:    93.6781   -6.2722   -0.1113    2.2521   -0.9958    1.9186    5.3383    0.4471    0.2427    0.1565    6.1081    1.6358
-#> 175:    93.7764   -6.1664   -0.1113    2.2468   -0.9864    1.6286    4.6233    0.4471    0.2426    0.1596    5.8892    1.6375
-#> 176:    93.9246   -6.2164   -0.1160    2.2529   -0.9853    1.0357    4.8013    0.4422    0.2471    0.1756    5.7340    1.6016
-#> 177:    93.9711   -6.1274   -0.1112    2.2540   -0.9883    1.2079    4.1536    0.4415    0.2492    0.1783    5.8399    1.6291
-#> 178:    93.9212   -6.0532   -0.1116    2.2593   -0.9742    1.2409    3.6443    0.4489    0.2458    0.1683    5.8422    1.6290
-#> 179:    94.0137   -6.0739   -0.1095    2.2664   -0.9778    1.5060    3.9878    0.4506    0.2370    0.1746    6.0349    1.6326
-#> 180:    93.9247   -6.0681   -0.1130    2.2660   -0.9934    1.9619    3.9582    0.4474    0.2328    0.1773    5.8082    1.6740
-#> 181:    93.7150   -6.0191   -0.1153    2.2558   -0.9915    2.6849    3.7075    0.4491    0.2283    0.1759    5.7187    1.6842
-#> 182:    93.5908   -6.1098   -0.1111    2.2769   -0.9942    3.0096    3.9325    0.4643    0.2275    0.1736    5.9243    1.6466
-#> 183:    93.3386   -6.0987   -0.1131    2.2630   -0.9962    3.5457    4.1285    0.4693    0.2373    0.1751    5.6948    1.7222
-#> 184:    93.4889   -6.3097   -0.1134    2.2660   -0.9720    3.0855    5.2642    0.4648    0.2255    0.1585    5.6827    1.7444
-#> 185:    93.6387   -6.1883   -0.1188    2.2622   -0.9603    3.3568    4.8291    0.4554    0.2223    0.1681    5.7089    1.8164
-#> 186:    93.3420   -6.2909   -0.1195    2.2656   -0.9835    3.2124    4.8317    0.4541    0.2286    0.1531    5.7574    1.7708
-#> 187:    93.4395   -6.0358   -0.1165    2.2528   -0.9917    3.8299    3.3301    0.4518    0.2370    0.1593    5.8508    1.6988
-#> 188:    93.5358   -6.0105   -0.1161    2.2540   -0.9813    5.1249    3.3448    0.4522    0.2361    0.1660    5.8700    1.6525
-#> 189:    93.4932   -6.1199   -0.1129    2.2636   -0.9812    4.5430    4.3213    0.4428    0.2359    0.1907    5.6970    1.7268
-#> 190:    93.4754   -5.9088   -0.1171    2.2564   -0.9614    4.6253    3.2590    0.4410    0.2399    0.1864    5.7116    1.8140
-#> 191:    93.4709   -5.9676   -0.1171    2.2568   -0.9748    4.8326    3.6704    0.4410    0.2428    0.1812    5.5925    1.7267
-#> 192:    93.3895   -5.9940   -0.1191    2.2523   -0.9691    4.3019    3.5174    0.4360    0.2484    0.1591    5.4631    1.7057
-#> 193:    93.4904   -6.0400   -0.1173    2.2519   -0.9697    4.6476    3.6255    0.4389    0.2388    0.1694    5.5362    1.7174
-#> 194:    93.4591   -5.9642   -0.1245    2.2626   -0.9559    5.3125    3.8133    0.4297    0.2550    0.1660    5.7591    1.7344
-#> 195:    93.6610   -6.2211   -0.1226    2.2580   -0.9669    5.2051    4.9271    0.4318    0.2414    0.1811    5.7010    1.7710
-#> 196:    93.4249   -5.9570   -0.1068    2.2735   -0.9727    5.1049    3.4872    0.4442    0.2429    0.1815    5.7753    1.7379
-#> 197:    93.4082   -6.0568   -0.1054    2.2754   -0.9865    5.2827    3.9305    0.4554    0.2408    0.1925    5.7514    1.7163
-#> 198:    93.3856   -5.8616   -0.1087    2.2708   -0.9686    4.1369    3.0197    0.4530    0.2473    0.1878    5.6920    1.7043
-#> 199:    93.5488   -6.0494   -0.1167    2.2682   -0.9719    3.8010    3.8897    0.4600    0.2445    0.1860    5.7126    1.6605
-#> 200:    93.3779   -5.9779   -0.1110    2.2761   -0.9780    3.5955    3.4721    0.4595    0.2468    0.1941    5.7539    1.6736
-#> 201:    93.4946   -6.0259   -0.1102    2.2676   -0.9755    3.0583    3.7305    0.4592    0.2554    0.1921    5.8877    1.6730
-#> 202:    93.4698   -6.0522   -0.1110    2.2685   -0.9703    2.9421    3.8718    0.4579    0.2595    0.1906    5.8527    1.6701
-#> 203:    93.4625   -6.0744   -0.1132    2.2642   -0.9696    3.1854    4.0983    0.4589    0.2596    0.1886    5.7532    1.6655
-#> 204:    93.4984   -6.0853   -0.1138    2.2589   -0.9718    3.2826    4.1667    0.4581    0.2588    0.1851    5.7274    1.6694
-#> 205:    93.5279   -6.1054   -0.1151    2.2562   -0.9742    3.3257    4.2680    0.4569    0.2584    0.1832    5.6976    1.6777
-#> 206:    93.6025   -6.1087   -0.1174    2.2518   -0.9767    3.2399    4.2443    0.4582    0.2589    0.1822    5.6809    1.6775
-#> 207:    93.6382   -6.0990   -0.1204    2.2481   -0.9801    3.2768    4.1473    0.4579    0.2591    0.1823    5.6460    1.6819
-#> 208:    93.6250   -6.0878   -0.1224    2.2438   -0.9812    3.1815    4.0872    0.4579    0.2577    0.1818    5.6256    1.6887
-#> 209:    93.6102   -6.0740   -0.1255    2.2394   -0.9803    3.1716    3.9968    0.4561    0.2573    0.1812    5.6063    1.6886
-#> 210:    93.6005   -6.0571   -0.1277    2.2348   -0.9799    3.2408    3.8923    0.4548    0.2572    0.1798    5.5849    1.6912
-#> 211:    93.6270   -6.0425   -0.1306    2.2292   -0.9807    3.3500    3.8267    0.4538    0.2586    0.1792    5.5578    1.6992
-#> 212:    93.6641   -6.0403   -0.1331    2.2253   -0.9806    3.4487    3.8366    0.4529    0.2596    0.1786    5.5422    1.7022
-#> 213:    93.6743   -6.0344   -0.1354    2.2214   -0.9800    3.5484    3.8260    0.4518    0.2606    0.1781    5.5250    1.7069
-#> 214:    93.6719   -6.0405   -0.1377    2.2179   -0.9804    3.5538    3.8785    0.4506    0.2612    0.1769    5.5148    1.7087
-#> 215:    93.6743   -6.0403   -0.1396    2.2146   -0.9801    3.5578    3.9180    0.4496    0.2615    0.1761    5.5118    1.7094
-#> 216:    93.6666   -6.0436   -0.1413    2.2115   -0.9796    3.5848    3.9484    0.4488    0.2624    0.1755    5.5015    1.7116
-#> 217:    93.6715   -6.0438   -0.1430    2.2086   -0.9794    3.6188    3.9603    0.4478    0.2631    0.1748    5.4884    1.7132
-#> 218:    93.6765   -6.0488   -0.1441    2.2060   -0.9796    3.6126    3.9885    0.4471    0.2632    0.1746    5.4714    1.7156
-#> 219:    93.6714   -6.0557   -0.1453    2.2038   -0.9798    3.6603    4.0118    0.4463    0.2632    0.1735    5.4593    1.7235
-#> 220:    93.6728   -6.0711   -0.1462    2.2027   -0.9794    3.7244    4.0910    0.4457    0.2639    0.1730    5.4531    1.7241
-#> 221:    93.6723   -6.0822   -0.1470    2.2015   -0.9788    3.7754    4.1554    0.4450    0.2647    0.1724    5.4511    1.7247
-#> 222:    93.6789   -6.0745   -0.1480    2.1998   -0.9780    3.8735    4.1186    0.4442    0.2662    0.1718    5.4419    1.7258
-#> 223:    93.6891   -6.0700   -0.1488    2.1984   -0.9778    3.9353    4.0998    0.4434    0.2681    0.1715    5.4375    1.7251
-#> 224:    93.7125   -6.0705   -0.1496    2.1976   -0.9774    4.0220    4.0861    0.4427    0.2697    0.1711    5.4378    1.7230
-#> 225:    93.7332   -6.0695   -0.1502    2.1966   -0.9775    4.0553    4.0669    0.4422    0.2712    0.1711    5.4355    1.7205
-#> 226:    93.7631   -6.0712   -0.1508    2.1951   -0.9779    4.0755    4.0572    0.4417    0.2728    0.1712    5.4347    1.7190
-#> 227:    93.7912   -6.0687   -0.1512    2.1938   -0.9785    4.0621    4.0439    0.4409    0.2742    0.1716    5.4325    1.7189
-#> 228:    93.8077   -6.0644   -0.1517    2.1927   -0.9791    4.0246    4.0190    0.4400    0.2755    0.1722    5.4269    1.7193
-#> 229:    93.8255   -6.0661   -0.1521    2.1909   -0.9796    3.9958    4.0166    0.4392    0.2769    0.1725    5.4214    1.7214
-#> 230:    93.8403   -6.0766   -0.1530    2.1895   -0.9802    4.0152    4.0548    0.4380    0.2788    0.1730    5.4214    1.7232
-#> 231:    93.8549   -6.0768   -0.1541    2.1877   -0.9810    4.0690    4.0542    0.4368    0.2803    0.1734    5.4157    1.7236
-#> 232:    93.8666   -6.0728   -0.1550    2.1858   -0.9816    4.0852    4.0337    0.4356    0.2818    0.1736    5.4136    1.7224
-#> 233:    93.8728   -6.0672   -0.1557    2.1844   -0.9820    4.1001    4.0000    0.4346    0.2828    0.1738    5.4028    1.7243
-#> 234:    93.8862   -6.0646   -0.1563    2.1830   -0.9825    4.1303    3.9850    0.4337    0.2838    0.1737    5.3924    1.7222
-#> 235:    93.8862   -6.0632   -0.1570    2.1819   -0.9827    4.1149    3.9735    0.4329    0.2847    0.1737    5.3846    1.7225
-#> 236:    93.8827   -6.0639   -0.1577    2.1814   -0.9834    4.1004    3.9711    0.4322    0.2852    0.1739    5.3838    1.7220
-#> 237:    93.8729   -6.0680   -0.1582    2.1808   -0.9840    4.0606    3.9866    0.4316    0.2857    0.1741    5.3806    1.7213
-#> 238:    93.8739   -6.0733   -0.1587    2.1806   -0.9845    4.0331    4.0011    0.4311    0.2859    0.1742    5.3775    1.7199
-#> 239:    93.8732   -6.0729   -0.1591    2.1802   -0.9853    3.9850    3.9892    0.4307    0.2859    0.1744    5.3782    1.7216
-#> 240:    93.8760   -6.0754   -0.1595    2.1796   -0.9854    3.9349    3.9867    0.4303    0.2858    0.1747    5.3781    1.7232
-#> 241:    93.8779   -6.0749   -0.1599    2.1791   -0.9853    3.9241    3.9801    0.4299    0.2858    0.1748    5.3757    1.7228
-#> 242:    93.8842   -6.0716   -0.1602    2.1786   -0.9852    3.9394    3.9651    0.4297    0.2859    0.1749    5.3726    1.7224
-#> 243:    93.8884   -6.0719   -0.1606    2.1778   -0.9851    3.9310    3.9741    0.4295    0.2857    0.1750    5.3705    1.7224
-#> 244:    93.8910   -6.0712   -0.1610    2.1771   -0.9850    3.9173    3.9819    0.4294    0.2856    0.1749    5.3700    1.7222
-#> 245:    93.9054   -6.0736   -0.1614    2.1764   -0.9854    3.9106    3.9984    0.4293    0.2856    0.1748    5.3711    1.7217
-#> 246:    93.9209   -6.0753   -0.1617    2.1757   -0.9859    3.9080    4.0071    0.4291    0.2852    0.1746    5.3711    1.7215
-#> 247:    93.9273   -6.0846   -0.1621    2.1752   -0.9861    3.8790    4.0580    0.4286    0.2851    0.1745    5.3755    1.7206
-#> 248:    93.9265   -6.0884   -0.1625    2.1749   -0.9865    3.8613    4.0784    0.4286    0.2848    0.1744    5.3760    1.7198
-#> 249:    93.9286   -6.0926   -0.1627    2.1746   -0.9872    3.8663    4.1008    0.4287    0.2845    0.1745    5.3755    1.7195
-#> 250:    93.9287   -6.0968   -0.1629    2.1744   -0.9878    3.8822    4.1269    0.4289    0.2844    0.1743    5.3755    1.7201
-#> 251:    93.9314   -6.1017   -0.1630    2.1739   -0.9882    3.8878    4.1495    0.4291    0.2843    0.1744    5.3729    1.7200
-#> 252:    93.9351   -6.1036   -0.1632    2.1734   -0.9885    3.8908    4.1545    0.4293    0.2843    0.1746    5.3684    1.7191
-#> 253:    93.9415   -6.1053   -0.1634    2.1729   -0.9889    3.8727    4.1602    0.4294    0.2842    0.1747    5.3650    1.7196
-#> 254:    93.9473   -6.1088   -0.1636    2.1723   -0.9891    3.8657    4.1769    0.4296    0.2843    0.1749    5.3666    1.7190
-#> 255:    93.9505   -6.1087   -0.1639    2.1717   -0.9888    3.8457    4.1720    0.4298    0.2841    0.1749    5.3617    1.7191
-#> 256:    93.9497   -6.1054   -0.1642    2.1715   -0.9885    3.8395    4.1559    0.4299    0.2839    0.1749    5.3598    1.7192
-#> 257:    93.9477   -6.1008   -0.1643    2.1713   -0.9882    3.8383    4.1360    0.4299    0.2836    0.1749    5.3567    1.7196
-#> 258:    93.9402   -6.0998   -0.1645    2.1713   -0.9880    3.8516    4.1288    0.4300    0.2832    0.1749    5.3565    1.7190
-#> 259:    93.9318   -6.0979   -0.1646    2.1711   -0.9879    3.8396    4.1182    0.4301    0.2829    0.1750    5.3583    1.7188
-#> 260:    93.9277   -6.1002   -0.1646    2.1713   -0.9879    3.8173    4.1273    0.4304    0.2826    0.1751    5.3611    1.7186
-#> 261:    93.9251   -6.0973   -0.1646    2.1714   -0.9879    3.8140    4.1105    0.4306    0.2822    0.1750    5.3588    1.7192
-#> 262:    93.9186   -6.1009   -0.1647    2.1715   -0.9880    3.8177    4.1303    0.4308    0.2822    0.1750    5.3604    1.7194
-#> 263:    93.9130   -6.1033   -0.1646    2.1715   -0.9880    3.8029    4.1529    0.4309    0.2822    0.1748    5.3647    1.7188
-#> 264:    93.9040   -6.1077   -0.1645    2.1717   -0.9879    3.7950    4.1820    0.4310    0.2822    0.1747    5.3699    1.7184
-#> 265:    93.9012   -6.1071   -0.1645    2.1714   -0.9879    3.7834    4.1895    0.4310    0.2822    0.1746    5.3755    1.7191
-#> 266:    93.8988   -6.1051   -0.1644    2.1714   -0.9879    3.7788    4.1822    0.4311    0.2822    0.1745    5.3765    1.7203
-#> 267:    93.8964   -6.1059   -0.1643    2.1714   -0.9877    3.7774    4.1896    0.4311    0.2822    0.1744    5.3792    1.7197
-#> 268:    93.8901   -6.1092   -0.1643    2.1715   -0.9876    3.7790    4.2198    0.4310    0.2822    0.1742    5.3811    1.7200
-#> 269:    93.8842   -6.1105   -0.1643    2.1717   -0.9875    3.7620    4.2336    0.4310    0.2823    0.1742    5.3838    1.7193
-#> 270:    93.8760   -6.1125   -0.1643    2.1721   -0.9874    3.7668    4.2483    0.4308    0.2823    0.1741    5.3852    1.7181
-#> 271:    93.8705   -6.1149   -0.1643    2.1722   -0.9873    3.7785    4.2625    0.4306    0.2823    0.1742    5.3853    1.7172
-#> 272:    93.8674   -6.1149   -0.1643    2.1723   -0.9871    3.7829    4.2581    0.4304    0.2823    0.1743    5.3836    1.7162
-#> 273:    93.8644   -6.1159   -0.1642    2.1725   -0.9870    3.7910    4.2631    0.4303    0.2825    0.1743    5.3818    1.7154
-#> 274:    93.8585   -6.1158   -0.1640    2.1728   -0.9869    3.7926    4.2612    0.4302    0.2825    0.1743    5.3816    1.7147
-#> 275:    93.8564   -6.1151   -0.1639    2.1732   -0.9867    3.8053    4.2581    0.4301    0.2826    0.1743    5.3804    1.7143
-#> 276:    93.8564   -6.1132   -0.1638    2.1736   -0.9866    3.7958    4.2486    0.4300    0.2827    0.1745    5.3810    1.7144
-#> 277:    93.8564   -6.1120   -0.1637    2.1741   -0.9867    3.7952    4.2426    0.4298    0.2829    0.1747    5.3808    1.7148
-#> 278:    93.8528   -6.1113   -0.1636    2.1743   -0.9867    3.7922    4.2352    0.4297    0.2832    0.1750    5.3819    1.7144
-#> 279:    93.8503   -6.1124   -0.1636    2.1744   -0.9867    3.7930    4.2390    0.4298    0.2834    0.1753    5.3826    1.7144
-#> 280:    93.8466   -6.1146   -0.1636    2.1743   -0.9867    3.7946    4.2470    0.4299    0.2838    0.1755    5.3832    1.7142
-#> 281:    93.8435   -6.1165   -0.1638    2.1743   -0.9867    3.7994    4.2552    0.4298    0.2840    0.1756    5.3828    1.7140
-#> 282:    93.8421   -6.1162   -0.1639    2.1741   -0.9868    3.7967    4.2496    0.4296    0.2843    0.1758    5.3816    1.7137
-#> 283:    93.8382   -6.1146   -0.1641    2.1740   -0.9866    3.7957    4.2387    0.4294    0.2845    0.1760    5.3796    1.7135
-#> 284:    93.8356   -6.1131   -0.1641    2.1740   -0.9865    3.7904    4.2263    0.4292    0.2848    0.1762    5.3776    1.7127
-#> 285:    93.8349   -6.1113   -0.1642    2.1740   -0.9865    3.7841    4.2129    0.4291    0.2850    0.1765    5.3763    1.7130
-#> 286:    93.8372   -6.1095   -0.1643    2.1741   -0.9864    3.7801    4.2035    0.4289    0.2853    0.1769    5.3779    1.7130
-#> 287:    93.8393   -6.1077   -0.1643    2.1741   -0.9864    3.7804    4.1908    0.4287    0.2857    0.1771    5.3785    1.7132
-#> 288:    93.8395   -6.1071   -0.1644    2.1740   -0.9866    3.7714    4.1834    0.4284    0.2859    0.1772    5.3798    1.7120
-#> 289:    93.8398   -6.1065   -0.1645    2.1738   -0.9865    3.7635    4.1765    0.4282    0.2861    0.1774    5.3821    1.7111
-#> 290:    93.8376   -6.1089   -0.1647    2.1737   -0.9865    3.7495    4.1853    0.4281    0.2863    0.1776    5.3852    1.7106
-#> 291:    93.8341   -6.1091   -0.1647    2.1738   -0.9863    3.7340    4.1854    0.4278    0.2865    0.1776    5.3868    1.7098
-#> 292:    93.8329   -6.1080   -0.1647    2.1741   -0.9863    3.7189    4.1760    0.4275    0.2868    0.1777    5.3885    1.7091
-#> 293:    93.8312   -6.1065   -0.1647    2.1743   -0.9862    3.7091    4.1651    0.4272    0.2871    0.1778    5.3896    1.7086
-#> 294:    93.8310   -6.1042   -0.1647    2.1745   -0.9861    3.6946    4.1521    0.4269    0.2874    0.1780    5.3908    1.7077
-#> 295:    93.8299   -6.1033   -0.1648    2.1747   -0.9861    3.6968    4.1433    0.4265    0.2880    0.1781    5.3904    1.7066
-#> 296:    93.8276   -6.1027   -0.1648    2.1749   -0.9862    3.7072    4.1361    0.4261    0.2885    0.1782    5.3910    1.7056
-#> 297:    93.8212   -6.1015   -0.1647    2.1750   -0.9859    3.7253    4.1278    0.4256    0.2891    0.1783    5.3927    1.7051
-#> 298:    93.8173   -6.0980   -0.1647    2.1751   -0.9858    3.7552    4.1115    0.4251    0.2897    0.1784    5.3932    1.7045
-#> 299:    93.8168   -6.0984   -0.1646    2.1754   -0.9856    3.7687    4.1143    0.4246    0.2902    0.1786    5.3949    1.7037
-#> 300:    93.8154   -6.0967   -0.1646    2.1756   -0.9855    3.7888    4.1072    0.4241    0.2906    0.1788    5.3962    1.7030
-#> 301:    93.8129   -6.0946   -0.1646    2.1757   -0.9852    3.8097    4.1006    0.4236    0.2911    0.1791    5.3971    1.7026
-#> 302:    93.8120   -6.0932   -0.1646    2.1759   -0.9849    3.8403    4.0955    0.4231    0.2917    0.1792    5.3971    1.7021
-#> 303:    93.8115   -6.0942   -0.1646    2.1762   -0.9850    3.8602    4.1004    0.4227    0.2922    0.1795    5.3976    1.7020
-#> 304:    93.8106   -6.0979   -0.1645    2.1765   -0.9850    3.8898    4.1217    0.4222    0.2926    0.1798    5.3975    1.7024
-#> 305:    93.8091   -6.1009   -0.1644    2.1767   -0.9851    3.9165    4.1374    0.4218    0.2931    0.1801    5.3989    1.7024
-#> 306:    93.8090   -6.1043   -0.1644    2.1770   -0.9850    3.9485    4.1617    0.4214    0.2936    0.1803    5.3998    1.7021
-#> 307:    93.8082   -6.1063   -0.1644    2.1772   -0.9850    3.9730    4.1797    0.4210    0.2940    0.1803    5.3998    1.7017
-#> 308:    93.8093   -6.1090   -0.1644    2.1775   -0.9850    3.9874    4.2026    0.4205    0.2945    0.1804    5.3996    1.7006
-#> 309:    93.8092   -6.1122   -0.1643    2.1777   -0.9849    3.9948    4.2297    0.4201    0.2948    0.1804    5.4001    1.6998
-#> 310:    93.8080   -6.1142   -0.1642    2.1780   -0.9850    3.9976    4.2436    0.4197    0.2951    0.1803    5.4016    1.6989
-#> 311:    93.8094   -6.1164   -0.1641    2.1784   -0.9851    4.0015    4.2552    0.4194    0.2952    0.1803    5.4033    1.6978
-#> 312:    93.8107   -6.1184   -0.1640    2.1788   -0.9851    4.0006    4.2628    0.4190    0.2954    0.1802    5.4042    1.6972
-#> 313:    93.8118   -6.1190   -0.1640    2.1789   -0.9851    3.9991    4.2638    0.4186    0.2955    0.1802    5.4053    1.6967
-#> 314:    93.8139   -6.1188   -0.1639    2.1791   -0.9851    4.0019    4.2619    0.4183    0.2956    0.1802    5.4049    1.6966
-#> 315:    93.8152   -6.1173   -0.1639    2.1792   -0.9851    4.0111    4.2553    0.4179    0.2957    0.1802    5.4052    1.6966
-#> 316:    93.8178   -6.1158   -0.1639    2.1792   -0.9851    4.0073    4.2498    0.4175    0.2957    0.1802    5.4050    1.6966
-#> 317:    93.8205   -6.1155   -0.1639    2.1792   -0.9851    3.9999    4.2491    0.4172    0.2957    0.1802    5.4048    1.6963
-#> 318:    93.8216   -6.1145   -0.1639    2.1792   -0.9850    3.9961    4.2438    0.4168    0.2957    0.1802    5.4031    1.6961
-#> 319:    93.8241   -6.1143   -0.1639    2.1792   -0.9849    4.0009    4.2412    0.4164    0.2958    0.1801    5.4004    1.6956
-#> 320:    93.8257   -6.1142   -0.1639    2.1792   -0.9849    4.0018    4.2380    0.4160    0.2958    0.1801    5.3986    1.6952
-#> 321:    93.8280   -6.1134   -0.1639    2.1792   -0.9849    4.0055    4.2339    0.4156    0.2959    0.1802    5.3966    1.6950
-#> 322:    93.8299   -6.1122   -0.1639    2.1793   -0.9848    4.0075    4.2274    0.4152    0.2959    0.1802    5.3969    1.6948
-#> 323:    93.8318   -6.1123   -0.1639    2.1794   -0.9848    4.0087    4.2257    0.4149    0.2960    0.1802    5.3980    1.6941
-#> 324:    93.8352   -6.1098   -0.1639    2.1795   -0.9848    4.0123    4.2136    0.4145    0.2960    0.1802    5.3988    1.6936
-#> 325:    93.8374   -6.1072   -0.1638    2.1796   -0.9848    4.0230    4.2005    0.4142    0.2961    0.1802    5.3991    1.6933
-#> 326:    93.8410   -6.1050   -0.1637    2.1796   -0.9849    4.0327    4.1891    0.4139    0.2963    0.1802    5.4004    1.6927
-#> 327:    93.8457   -6.1023   -0.1637    2.1796   -0.9849    4.0327    4.1767    0.4135    0.2964    0.1802    5.4013    1.6922
-#> 328:    93.8493   -6.1017   -0.1637    2.1797   -0.9850    4.0440    4.1730    0.4131    0.2964    0.1802    5.4019    1.6915
-#> 329:    93.8515   -6.1001   -0.1637    2.1799   -0.9851    4.0556    4.1648    0.4128    0.2963    0.1803    5.4017    1.6912
-#> 330:    93.8541   -6.1001   -0.1636    2.1800   -0.9852    4.0606    4.1631    0.4124    0.2962    0.1804    5.4025    1.6912
-#> 331:    93.8539   -6.0994   -0.1635    2.1801   -0.9854    4.0654    4.1584    0.4120    0.2961    0.1805    5.4025    1.6907
-#> 332:    93.8536   -6.0999   -0.1634    2.1803   -0.9854    4.0696    4.1601    0.4116    0.2960    0.1808    5.4027    1.6904
-#> 333:    93.8531   -6.1002   -0.1633    2.1806   -0.9853    4.0682    4.1646    0.4112    0.2960    0.1810    5.4038    1.6893
-#> 334:    93.8543   -6.1005   -0.1632    2.1809   -0.9852    4.0771    4.1690    0.4108    0.2960    0.1812    5.4040    1.6883
-#> 335:    93.8552   -6.1010   -0.1631    2.1813   -0.9851    4.0888    4.1775    0.4104    0.2960    0.1813    5.4044    1.6878
-#> 336:    93.8555   -6.1016   -0.1630    2.1817   -0.9850    4.0969    4.1858    0.4099    0.2961    0.1814    5.4046    1.6873
-#> 337:    93.8553   -6.1025   -0.1628    2.1820   -0.9849    4.1152    4.1921    0.4094    0.2962    0.1815    5.4070    1.6863
-#> 338:    93.8553   -6.1018   -0.1626    2.1824   -0.9848    4.1314    4.1904    0.4090    0.2963    0.1816    5.4080    1.6852
-#> 339:    93.8567   -6.1004   -0.1625    2.1828   -0.9847    4.1449    4.1855    0.4087    0.2964    0.1817    5.4087    1.6841
-#> 340:    93.8582   -6.0987   -0.1623    2.1832   -0.9846    4.1603    4.1799    0.4083    0.2965    0.1819    5.4086    1.6832
-#> 341:    93.8589   -6.0962   -0.1620    2.1836   -0.9844    4.1692    4.1694    0.4079    0.2965    0.1820    5.4102    1.6828
-#> 342:    93.8583   -6.0932   -0.1618    2.1841   -0.9844    4.1729    4.1563    0.4075    0.2966    0.1821    5.4117    1.6821
-#> 343:    93.8590   -6.0906   -0.1615    2.1845   -0.9844    4.1840    4.1447    0.4071    0.2966    0.1822    5.4125    1.6819
-#> 344:    93.8582   -6.0890   -0.1613    2.1851   -0.9845    4.1860    4.1347    0.4068    0.2968    0.1826    5.4135    1.6814
-#> 345:    93.8576   -6.0876   -0.1610    2.1857   -0.9846    4.1889    4.1252    0.4064    0.2969    0.1829    5.4143    1.6810
-#> 346:    93.8549   -6.0853   -0.1608    2.1862   -0.9845    4.1925    4.1121    0.4061    0.2969    0.1832    5.4157    1.6803
-#> 347:    93.8540   -6.0829   -0.1605    2.1867   -0.9845    4.2031    4.0990    0.4058    0.2970    0.1834    5.4158    1.6803
-#> 348:    93.8516   -6.0814   -0.1602    2.1873   -0.9845    4.2169    4.0885    0.4055    0.2971    0.1836    5.4174    1.6801
-#> 349:    93.8505   -6.0797   -0.1600    2.1879   -0.9845    4.2253    4.0779    0.4052    0.2971    0.1837    5.4190    1.6799
-#> 350:    93.8512   -6.0773   -0.1597    2.1885   -0.9845    4.2268    4.0657    0.4049    0.2972    0.1839    5.4209    1.6797
-#> 351:    93.8507   -6.0754   -0.1595    2.1890   -0.9845    4.2245    4.0559    0.4046    0.2972    0.1840    5.4230    1.6794
-#> 352:    93.8490   -6.0736   -0.1592    2.1896   -0.9845    4.2296    4.0474    0.4044    0.2973    0.1841    5.4252    1.6790
-#> 353:    93.8460   -6.0718   -0.1589    2.1901   -0.9845    4.2356    4.0374    0.4042    0.2973    0.1843    5.4272    1.6790
-#> 354:    93.8437   -6.0695   -0.1586    2.1906   -0.9845    4.2408    4.0255    0.4041    0.2973    0.1844    5.4303    1.6787
-#> 355:    93.8420   -6.0679   -0.1584    2.1912   -0.9844    4.2428    4.0166    0.4040    0.2973    0.1845    5.4342    1.6785
-#> 356:    93.8413   -6.0666   -0.1581    2.1916   -0.9843    4.2418    4.0072    0.4040    0.2973    0.1845    5.4348    1.6792
-#> 357:    93.8406   -6.0650   -0.1578    2.1921   -0.9844    4.2531    3.9973    0.4040    0.2973    0.1846    5.4350    1.6798
-#> 358:    93.8404   -6.0639   -0.1575    2.1926   -0.9844    4.2596    3.9901    0.4040    0.2973    0.1846    5.4357    1.6805
-#> 359:    93.8373   -6.0630   -0.1572    2.1931   -0.9845    4.2724    3.9820    0.4039    0.2973    0.1848    5.4368    1.6816
-#> 360:    93.8347   -6.0622   -0.1569    2.1936   -0.9845    4.2788    3.9747    0.4039    0.2973    0.1849    5.4377    1.6824
-#> 361:    93.8327   -6.0626   -0.1566    2.1942   -0.9846    4.2919    3.9749    0.4038    0.2973    0.1850    5.4382    1.6831
-#> 362:    93.8326   -6.0629   -0.1562    2.1947   -0.9846    4.2989    3.9737    0.4038    0.2973    0.1850    5.4408    1.6838
-#> 363:    93.8316   -6.0629   -0.1559    2.1953   -0.9846    4.3007    3.9725    0.4037    0.2972    0.1850    5.4420    1.6842
-#> 364:    93.8317   -6.0629   -0.1556    2.1957   -0.9846    4.2910    3.9739    0.4038    0.2971    0.1850    5.4430    1.6840
-#> 365:    93.8317   -6.0629   -0.1553    2.1962   -0.9846    4.2878    3.9759    0.4040    0.2967    0.1849    5.4441    1.6839
-#> 366:    93.8319   -6.0633   -0.1549    2.1966   -0.9845    4.2870    3.9823    0.4042    0.2963    0.1849    5.4461    1.6839
-#> 367:    93.8320   -6.0636   -0.1546    2.1971   -0.9845    4.2828    3.9850    0.4042    0.2959    0.1849    5.4479    1.6843
-#> 368:    93.8312   -6.0635   -0.1544    2.1975   -0.9844    4.2781    3.9859    0.4043    0.2955    0.1849    5.4475    1.6841
-#> 369:    93.8301   -6.0640   -0.1541    2.1979   -0.9844    4.2760    3.9891    0.4043    0.2953    0.1850    5.4472    1.6835
-#> 370:    93.8306   -6.0651   -0.1539    2.1983   -0.9844    4.2690    3.9967    0.4042    0.2950    0.1850    5.4484    1.6829
-#> 371:    93.8312   -6.0669   -0.1536    2.1988   -0.9845    4.2613    4.0111    0.4042    0.2947    0.1851    5.4494    1.6822
-#> 372:    93.8312   -6.0681   -0.1533    2.1992   -0.9845    4.2585    4.0252    0.4042    0.2945    0.1852    5.4513    1.6817
-#> 373:    93.8307   -6.0681   -0.1531    2.1996   -0.9846    4.2605    4.0284    0.4042    0.2943    0.1853    5.4523    1.6815
-#> 374:    93.8305   -6.0678   -0.1529    2.1999   -0.9846    4.2676    4.0279    0.4040    0.2942    0.1853    5.4533    1.6816
-#> 375:    93.8313   -6.0673   -0.1528    2.2002   -0.9846    4.2708    4.0232    0.4038    0.2940    0.1854    5.4543    1.6813
-#> 376:    93.8310   -6.0672   -0.1527    2.2004   -0.9846    4.2775    4.0214    0.4037    0.2938    0.1855    5.4538    1.6809
-#> 377:    93.8298   -6.0666   -0.1526    2.2007   -0.9846    4.2787    4.0166    0.4035    0.2937    0.1856    5.4532    1.6806
-#> 378:    93.8276   -6.0664   -0.1525    2.2009   -0.9846    4.2781    4.0135    0.4033    0.2935    0.1857    5.4538    1.6801
-#> 379:    93.8262   -6.0671   -0.1524    2.2012   -0.9846    4.2800    4.0157    0.4031    0.2932    0.1857    5.4530    1.6803
-#> 380:    93.8243   -6.0675   -0.1523    2.2015   -0.9846    4.2735    4.0168    0.4029    0.2929    0.1857    5.4523    1.6803
-#> 381:    93.8233   -6.0677   -0.1522    2.2017   -0.9845    4.2670    4.0189    0.4027    0.2926    0.1858    5.4517    1.6798
-#> 382:    93.8229   -6.0674   -0.1521    2.2019   -0.9845    4.2655    4.0211    0.4025    0.2924    0.1858    5.4510    1.6794
-#> 383:    93.8196   -6.0681   -0.1521    2.2021   -0.9843    4.2696    4.0291    0.4023    0.2922    0.1859    5.4504    1.6788
-#> 384:    93.8174   -6.0688   -0.1520    2.2023   -0.9842    4.2851    4.0333    0.4021    0.2919    0.1860    5.4500    1.6783
-#> 385:    93.8156   -6.0682   -0.1518    2.2028   -0.9840    4.3056    4.0305    0.4019    0.2920    0.1862    5.4503    1.6774
-#> 386:    93.8145   -6.0684   -0.1516    2.2032   -0.9838    4.3195    4.0302    0.4016    0.2920    0.1863    5.4499    1.6765
-#> 387:    93.8121   -6.0679   -0.1514    2.2036   -0.9837    4.3290    4.0272    0.4014    0.2920    0.1864    5.4501    1.6756
-#> 388:    93.8105   -6.0676   -0.1513    2.2040   -0.9835    4.3393    4.0267    0.4011    0.2920    0.1865    5.4509    1.6751
-#> 389:    93.8089   -6.0664   -0.1510    2.2045   -0.9833    4.3458    4.0224    0.4009    0.2920    0.1865    5.4512    1.6746
-#> 390:    93.8080   -6.0658   -0.1508    2.2049   -0.9832    4.3422    4.0199    0.4007    0.2920    0.1866    5.4514    1.6744
-#> 391:    93.8077   -6.0669   -0.1507    2.2053   -0.9831    4.3500    4.0277    0.4007    0.2920    0.1867    5.4511    1.6740
-#> 392:    93.8069   -6.0676   -0.1505    2.2056   -0.9831    4.3525    4.0326    0.4006    0.2920    0.1868    5.4500    1.6733
-#> 393:    93.8072   -6.0678   -0.1504    2.2059   -0.9830    4.3562    4.0344    0.4005    0.2920    0.1868    5.4491    1.6725
-#> 394:    93.8083   -6.0684   -0.1503    2.2061   -0.9829    4.3577    4.0386    0.4004    0.2920    0.1869    5.4493    1.6716
-#> 395:    93.8086   -6.0685   -0.1501    2.2064   -0.9828    4.3574    4.0394    0.4003    0.2920    0.1869    5.4493    1.6709
-#> 396:    93.8078   -6.0677   -0.1500    2.2067   -0.9827    4.3591    4.0355    0.4002    0.2921    0.1870    5.4493    1.6707
-#> 397:    93.8064   -6.0668   -0.1499    2.2071   -0.9825    4.3621    4.0317    0.4000    0.2922    0.1871    5.4495    1.6704
-#> 398:    93.8058   -6.0661   -0.1499    2.2073   -0.9823    4.3701    4.0285    0.3999    0.2923    0.1872    5.4491    1.6699
-#> 399:    93.8057   -6.0651   -0.1498    2.2075   -0.9822    4.3803    4.0243    0.3997    0.2924    0.1872    5.4485    1.6699
-#> 400:    93.8057   -6.0647   -0.1498    2.2076   -0.9820    4.3854    4.0225    0.3996    0.2924    0.1872    5.4488    1.6699
-#> 401:    93.8059   -6.0635   -0.1498    2.2078   -0.9819    4.3939    4.0178    0.3995    0.2925    0.1873    5.4491    1.6702
-#> 402:    93.8063   -6.0621   -0.1498    2.2079   -0.9818    4.4033    4.0120    0.3993    0.2926    0.1875    5.4492    1.6704
-#> 403:    93.8055   -6.0609   -0.1498    2.2080   -0.9816    4.4098    4.0069    0.3992    0.2926    0.1876    5.4494    1.6703
-#> 404:    93.8040   -6.0608   -0.1499    2.2081   -0.9815    4.4153    4.0050    0.3991    0.2927    0.1877    5.4494    1.6701
-#> 405:    93.8030   -6.0604   -0.1499    2.2082   -0.9814    4.4181    4.0047    0.3990    0.2928    0.1879    5.4491    1.6700
-#> 406:    93.8002   -6.0597   -0.1499    2.2083   -0.9812    4.4257    4.0025    0.3989    0.2928    0.1880    5.4498    1.6702
-#> 407:    93.7969   -6.0593   -0.1500    2.2085   -0.9810    4.4343    3.9994    0.3988    0.2928    0.1881    5.4514    1.6703
-#> 408:    93.7947   -6.0582   -0.1499    2.2087   -0.9809    4.4509    3.9936    0.3987    0.2927    0.1882    5.4526    1.6704
-#> 409:    93.7929   -6.0579   -0.1499    2.2088   -0.9807    4.4584    3.9918    0.3987    0.2926    0.1882    5.4537    1.6707
-#> 410:    93.7896   -6.0593   -0.1499    2.2089   -0.9807    4.4664    4.0002    0.3987    0.2925    0.1883    5.4560    1.6705
-#> 411:    93.7875   -6.0601   -0.1499    2.2090   -0.9807    4.4626    4.0057    0.3987    0.2924    0.1883    5.4567    1.6705
-#> 412:    93.7862   -6.0602   -0.1499    2.2091   -0.9808    4.4574    4.0095    0.3986    0.2923    0.1884    5.4565    1.6706
-#> 413:    93.7858   -6.0606   -0.1498    2.2092   -0.9808    4.4527    4.0146    0.3986    0.2922    0.1885    5.4561    1.6708
-#> 414:    93.7859   -6.0615   -0.1498    2.2093   -0.9808    4.4451    4.0211    0.3987    0.2921    0.1885    5.4574    1.6708
-#> 415:    93.7864   -6.0629   -0.1498    2.2092   -0.9808    4.4443    4.0298    0.3986    0.2921    0.1885    5.4576    1.6707
-#> 416:    93.7851   -6.0639   -0.1498    2.2092   -0.9808    4.4462    4.0362    0.3985    0.2920    0.1884    5.4575    1.6706
-#> 417:    93.7820   -6.0644   -0.1499    2.2092   -0.9808    4.4425    4.0387    0.3985    0.2920    0.1884    5.4577    1.6703
-#> 418:    93.7801   -6.0652   -0.1499    2.2093   -0.9808    4.4365    4.0420    0.3985    0.2920    0.1883    5.4589    1.6702
-#> 419:    93.7799   -6.0648   -0.1499    2.2094   -0.9807    4.4303    4.0418    0.3984    0.2921    0.1883    5.4596    1.6703
-#> 420:    93.7797   -6.0641   -0.1498    2.2095   -0.9807    4.4216    4.0383    0.3983    0.2921    0.1884    5.4607    1.6702
-#> 421:    93.7803   -6.0641   -0.1498    2.2096   -0.9808    4.4120    4.0396    0.3983    0.2922    0.1885    5.4621    1.6702
-#> 422:    93.7806   -6.0638   -0.1498    2.2097   -0.9809    4.4017    4.0373    0.3981    0.2923    0.1885    5.4635    1.6702
-#> 423:    93.7800   -6.0636   -0.1498    2.2098   -0.9810    4.3948    4.0339    0.3981    0.2923    0.1885    5.4640    1.6701
-#> 424:    93.7789   -6.0638   -0.1498    2.2099   -0.9810    4.3884    4.0336    0.3980    0.2924    0.1885    5.4651    1.6700
-#> 425:    93.7774   -6.0628   -0.1498    2.2101   -0.9810    4.3814    4.0271    0.3978    0.2925    0.1884    5.4666    1.6699
-#> 426:    93.7755   -6.0619   -0.1498    2.2102   -0.9811    4.3841    4.0221    0.3977    0.2925    0.1884    5.4693    1.6697
-#> 427:    93.7753   -6.0612   -0.1498    2.2103   -0.9810    4.3785    4.0167    0.3975    0.2926    0.1883    5.4712    1.6696
-#> 428:    93.7741   -6.0613   -0.1498    2.2104   -0.9810    4.3767    4.0161    0.3973    0.2926    0.1882    5.4729    1.6696
-#> 429:    93.7717   -6.0613   -0.1498    2.2105   -0.9810    4.3744    4.0158    0.3971    0.2926    0.1880    5.4743    1.6694
-#> 430:    93.7690   -6.0619   -0.1498    2.2106   -0.9809    4.3744    4.0189    0.3969    0.2926    0.1879    5.4753    1.6692
-#> 431:    93.7668   -6.0615   -0.1498    2.2107   -0.9809    4.3709    4.0174    0.3967    0.2925    0.1878    5.4762    1.6691
-#> 432:    93.7656   -6.0619   -0.1498    2.2108   -0.9809    4.3710    4.0173    0.3966    0.2926    0.1878    5.4770    1.6688
-#> 433:    93.7632   -6.0625   -0.1498    2.2108   -0.9809    4.3689    4.0204    0.3964    0.2926    0.1877    5.4774    1.6687
-#> 434:    93.7624   -6.0621   -0.1498    2.2109   -0.9808    4.3687    4.0178    0.3962    0.2926    0.1876    5.4774    1.6683
-#> 435:    93.7608   -6.0622   -0.1497    2.2111   -0.9808    4.3714    4.0182    0.3961    0.2927    0.1875    5.4777    1.6679
-#> 436:    93.7586   -6.0622   -0.1498    2.2112   -0.9808    4.3695    4.0178    0.3959    0.2928    0.1874    5.4784    1.6679
-#> 437:    93.7558   -6.0622   -0.1498    2.2114   -0.9809    4.3658    4.0167    0.3957    0.2928    0.1873    5.4795    1.6678
-#> 438:    93.7519   -6.0627   -0.1499    2.2115   -0.9808    4.3601    4.0183    0.3955    0.2928    0.1872    5.4807    1.6674
-#> 439:    93.7478   -6.0618   -0.1499    2.2115   -0.9807    4.3538    4.0133    0.3952    0.2928    0.1871    5.4814    1.6672
-#> 440:    93.7449   -6.0612   -0.1499    2.2117   -0.9805    4.3504    4.0103    0.3951    0.2928    0.1870    5.4820    1.6669
-#> 441:    93.7433   -6.0608   -0.1499    2.2117   -0.9805    4.3438    4.0077    0.3949    0.2928    0.1869    5.4818    1.6666
-#> 442:    93.7417   -6.0604   -0.1500    2.2118   -0.9805    4.3354    4.0058    0.3947    0.2927    0.1868    5.4824    1.6666
-#> 443:    93.7407   -6.0604   -0.1500    2.2119   -0.9805    4.3281    4.0046    0.3946    0.2927    0.1867    5.4832    1.6667
-#> 444:    93.7397   -6.0608   -0.1500    2.2118   -0.9805    4.3180    4.0069    0.3944    0.2928    0.1866    5.4857    1.6664
-#> 445:    93.7387   -6.0613   -0.1501    2.2118   -0.9805    4.3092    4.0085    0.3942    0.2929    0.1866    5.4866    1.6663
-#> 446:    93.7376   -6.0612   -0.1502    2.2117   -0.9805    4.3022    4.0075    0.3939    0.2930    0.1865    5.4866    1.6660
-#> 447:    93.7375   -6.0613   -0.1503    2.2116   -0.9806    4.2981    4.0076    0.3937    0.2931    0.1865    5.4863    1.6658
-#> 448:    93.7388   -6.0617   -0.1504    2.2115   -0.9806    4.2970    4.0087    0.3935    0.2932    0.1864    5.4870    1.6658
-#> 449:    93.7400   -6.0617   -0.1504    2.2115   -0.9807    4.2904    4.0069    0.3933    0.2933    0.1864    5.4880    1.6655
-#> 450:    93.7414   -6.0623   -0.1505    2.2113   -0.9808    4.2829    4.0095    0.3930    0.2935    0.1863    5.4880    1.6653
-#> 451:    93.7426   -6.0634   -0.1506    2.2112   -0.9808    4.2797    4.0146    0.3928    0.2936    0.1863    5.4877    1.6655
-#> 452:    93.7447   -6.0642   -0.1507    2.2110   -0.9809    4.2770    4.0171    0.3926    0.2938    0.1862    5.4876    1.6657
-#> 453:    93.7465   -6.0644   -0.1508    2.2108   -0.9810    4.2698    4.0184    0.3924    0.2940    0.1862    5.4877    1.6652
-#> 454:    93.7478   -6.0645   -0.1509    2.2106   -0.9810    4.2657    4.0182    0.3922    0.2941    0.1861    5.4874    1.6648
-#> 455:    93.7486   -6.0650   -0.1511    2.2104   -0.9811    4.2656    4.0203    0.3921    0.2943    0.1861    5.4871    1.6644
-#> 456:    93.7485   -6.0659   -0.1512    2.2102   -0.9812    4.2646    4.0240    0.3920    0.2945    0.1860    5.4869    1.6641
-#> 457:    93.7487   -6.0668   -0.1514    2.2099   -0.9813    4.2613    4.0277    0.3919    0.2946    0.1860    5.4866    1.6640
-#> 458:    93.7484   -6.0667   -0.1515    2.2097   -0.9812    4.2586    4.0263    0.3918    0.2947    0.1859    5.4854    1.6639
-#> 459:    93.7468   -6.0661   -0.1517    2.2095   -0.9812    4.2565    4.0225    0.3917    0.2948    0.1858    5.4853    1.6639
-#> 460:    93.7458   -6.0652   -0.1518    2.2093   -0.9812    4.2548    4.0171    0.3916    0.2950    0.1858    5.4843    1.6638
-#> 461:    93.7435   -6.0645   -0.1519    2.2091   -0.9811    4.2554    4.0121    0.3914    0.2951    0.1858    5.4843    1.6637
-#> 462:    93.7421   -6.0637   -0.1521    2.2089   -0.9811    4.2509    4.0079    0.3913    0.2953    0.1857    5.4840    1.6638
-#> 463:    93.7406   -6.0630   -0.1522    2.2088   -0.9810    4.2534    4.0036    0.3912    0.2955    0.1857    5.4834    1.6640
-#> 464:    93.7406   -6.0622   -0.1524    2.2086   -0.9810    4.2548    3.9986    0.3911    0.2956    0.1857    5.4828    1.6639
-#> 465:    93.7404   -6.0617   -0.1525    2.2084   -0.9810    4.2511    3.9955    0.3910    0.2958    0.1857    5.4828    1.6638
-#> 466:    93.7414   -6.0610   -0.1527    2.2080   -0.9809    4.2468    3.9918    0.3910    0.2959    0.1857    5.4812    1.6640
-#> 467:    93.7419   -6.0606   -0.1529    2.2077   -0.9810    4.2446    3.9885    0.3909    0.2960    0.1858    5.4799    1.6642
-#> 468:    93.7427   -6.0604   -0.1531    2.2074   -0.9809    4.2473    3.9872    0.3909    0.2961    0.1858    5.4790    1.6643
-#> 469:    93.7435   -6.0608   -0.1532    2.2073   -0.9810    4.2457    3.9891    0.3907    0.2963    0.1858    5.4789    1.6641
-#> 470:    93.7442   -6.0611   -0.1533    2.2071   -0.9811    4.2443    3.9895    0.3905    0.2965    0.1858    5.4785    1.6640
-#> 471:    93.7443   -6.0618   -0.1534    2.2070   -0.9812    4.2415    3.9932    0.3903    0.2967    0.1858    5.4773    1.6639
-#> 472:    93.7433   -6.0624   -0.1535    2.2069   -0.9812    4.2414    3.9958    0.3901    0.2969    0.1858    5.4765    1.6637
-#> 473:    93.7421   -6.0621   -0.1536    2.2067   -0.9811    4.2330    3.9962    0.3899    0.2970    0.1858    5.4762    1.6637
-#> 474:    93.7415   -6.0621   -0.1537    2.2066   -0.9812    4.2263    3.9968    0.3897    0.2972    0.1858    5.4755    1.6638
-#> 475:    93.7396   -6.0621   -0.1538    2.2066   -0.9812    4.2261    3.9956    0.3895    0.2973    0.1859    5.4751    1.6637
-#> 476:    93.7373   -6.0626   -0.1539    2.2065   -0.9811    4.2265    3.9976    0.3893    0.2975    0.1859    5.4743    1.6634
-#> 477:    93.7357   -6.0623   -0.1540    2.2063   -0.9811    4.2222    3.9953    0.3891    0.2976    0.1859    5.4741    1.6635
-#> 478:    93.7345   -6.0620   -0.1541    2.2062   -0.9811    4.2165    3.9939    0.3889    0.2978    0.1860    5.4745    1.6638
-#> 479:    93.7341   -6.0615   -0.1542    2.2062   -0.9812    4.2122    3.9916    0.3887    0.2979    0.1860    5.4751    1.6637
-#> 480:    93.7338   -6.0619   -0.1543    2.2061   -0.9812    4.2084    3.9932    0.3885    0.2980    0.1860    5.4753    1.6635
-#> 481:    93.7336   -6.0618   -0.1544    2.2060   -0.9812    4.2066    3.9945    0.3883    0.2981    0.1860    5.4748    1.6637
-#> 482:    93.7340   -6.0622   -0.1545    2.2058   -0.9812    4.2069    3.9969    0.3882    0.2983    0.1860    5.4741    1.6636
-#> 483:    93.7328   -6.0627   -0.1547    2.2057   -0.9813    4.2062    3.9992    0.3879    0.2985    0.1861    5.4739    1.6636
-#> 484:    93.7323   -6.0629   -0.1547    2.2056   -0.9813    4.2075    3.9995    0.3877    0.2987    0.1861    5.4730    1.6638
-#> 485:    93.7326   -6.0634   -0.1548    2.2055   -0.9814    4.2045    4.0013    0.3875    0.2989    0.1862    5.4727    1.6637
-#> 486:    93.7320   -6.0632   -0.1549    2.2055   -0.9814    4.2084    3.9989    0.3872    0.2991    0.1863    5.4718    1.6635
-#> 487:    93.7321   -6.0625   -0.1549    2.2054   -0.9814    4.2105    3.9949    0.3870    0.2993    0.1864    5.4712    1.6634
-#> 488:    93.7326   -6.0623   -0.1550    2.2054   -0.9814    4.2104    3.9935    0.3868    0.2996    0.1865    5.4721    1.6635
-#> 489:    93.7342   -6.0615   -0.1551    2.2054   -0.9815    4.2103    3.9893    0.3866    0.2998    0.1866    5.4725    1.6635
-#> 490:    93.7360   -6.0610   -0.1551    2.2053   -0.9815    4.2116    3.9857    0.3864    0.3001    0.1867    5.4730    1.6636
-#> 491:    93.7374   -6.0601   -0.1551    2.2052   -0.9815    4.2128    3.9804    0.3862    0.3003    0.1868    5.4722    1.6638
-#> 492:    93.7386   -6.0597   -0.1552    2.2050   -0.9816    4.2171    3.9774    0.3861    0.3006    0.1869    5.4714    1.6642
-#> 493:    93.7399   -6.0597   -0.1553    2.2049   -0.9816    4.2262    3.9766    0.3859    0.3008    0.1869    5.4712    1.6643
-#> 494:    93.7404   -6.0596   -0.1553    2.2047   -0.9816    4.2347    3.9746    0.3857    0.3011    0.1870    5.4711    1.6646
-#> 495:    93.7406   -6.0590   -0.1554    2.2046   -0.9817    4.2395    3.9711    0.3855    0.3014    0.1871    5.4705    1.6650
-#> 496:    93.7416   -6.0582   -0.1554    2.2045   -0.9817    4.2456    3.9660    0.3853    0.3017    0.1871    5.4707    1.6656
-#> 497:    93.7433   -6.0575   -0.1555    2.2044   -0.9818    4.2511    3.9631    0.3851    0.3020    0.1871    5.4714    1.6658
-#> 498:    93.7444   -6.0574   -0.1556    2.2042   -0.9817    4.2516    3.9632    0.3848    0.3023    0.1871    5.4721    1.6660
-#> 499:    93.7457   -6.0576   -0.1557    2.2041   -0.9817    4.2518    3.9660    0.3846    0.3025    0.1871    5.4728    1.6660
-#> 500:    93.7469   -6.0586   -0.1557    2.2040   -0.9817    4.2481    3.9757    0.3844    0.3028    0.1871    5.4738    1.6661
-#> Calculating covariance matrix
-#> 
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Calculating residuals/tables
-#> done
-f_nlmixr_fomc_sfo_focei_obs <- nlmixr(f_mmkin_obs["FOMC-SFO", ], est = "focei")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
-#> F: Forward difference gradient approximation
-#> C: Central difference gradient approximation
-#> M: Mixed forward and central difference gradient approximation
-#> Unscaled parameters for Omegas=chol(solve(omega));
-#> Diagonals are transformed, as specified by foceiControl(diagXform=)
-#> |-----+---------------+-----------+-----------+-----------+-----------|
-#> |    #| Objective Fun |  parent_0 |  log_k_A1 |f_parent_qlogis | log_alpha |
-#> |.....................|  log_beta |sigma_parent |  sigma_A1 |        o1 |
-#> |.....................|        o2 |        o3 |        o4 |        o5 |
-#> |    1|     468.02617 |     1.000 |    -1.000 |   -0.9113 |   -0.8954 |
-#> |.....................|   -0.8491 |   -0.8511 |   -0.8672 |   -0.8762 |
-#> |.....................|   -0.8737 |   -0.8674 |   -0.8694 |   -0.8687 |
-#> |    U|     468.02617 |     94.00 |    -5.400 |   -0.9900 |   -0.2000 |
-#> |.....................|     2.100 |     2.000 |     1.200 |    0.7536 |
-#> |.....................|    0.8758 |     1.189 |     1.093 |     1.127 |
-#> |    X|     468.02617 |     94.00 |  0.004517 |    0.2709 |    0.8187 |
-#> |.....................|     8.166 |     2.000 |     1.200 |    0.7536 |
-#> |.....................|    0.8758 |     1.189 |     1.093 |     1.127 |
-#> |    G|    Gill Diff. |     49.30 |     2.016 |   -0.2473 |   -0.3737 |
-#> |.....................|    -1.227 |    -27.89 |    -10.29 |     8.753 |
-#> |.....................|     11.17 |    -12.52 |    -9.819 |    -8.910 |
-#> |    2|     4021.4865 |    0.2059 |    -1.032 |   -0.9073 |   -0.8894 |
-#> |.....................|   -0.8293 |   -0.4019 |   -0.7014 |    -1.017 |
-#> |.....................|    -1.054 |   -0.6658 |   -0.7112 |   -0.7251 |
-#> |    U|     4021.4865 |     19.35 |    -5.432 |   -0.9861 |   -0.1940 |
-#> |.....................|     2.120 |     2.449 |     1.299 |    0.6474 |
-#> |.....................|    0.7182 |     1.429 |     1.266 |     1.289 |
-#> |    X|     4021.4865 |     19.35 |  0.004372 |    0.2717 |    0.8237 |
-#> |.....................|     8.329 |     2.449 |     1.299 |    0.6474 |
-#> |.....................|    0.7182 |     1.429 |     1.266 |     1.289 |
-#> |    3|     518.20369 |    0.9206 |    -1.003 |   -0.9109 |   -0.8948 |
-#> |.....................|   -0.8471 |   -0.8062 |   -0.8506 |   -0.8903 |
-#> |.....................|   -0.8917 |   -0.8473 |   -0.8535 |   -0.8543 |
-#> |    U|     518.20369 |     86.53 |    -5.403 |   -0.9896 |   -0.1994 |
-#> |.....................|     2.102 |     2.045 |     1.210 |    0.7430 |
-#> |.....................|    0.8600 |     1.213 |     1.111 |     1.143 |
-#> |    X|     518.20369 |     86.53 |  0.004502 |    0.2710 |    0.8192 |
-#> |.....................|     8.182 |     2.045 |     1.210 |    0.7430 |
-#> |.....................|    0.8600 |     1.213 |     1.111 |     1.143 |
-#> |    4|     467.99742 |    0.9921 |    -1.000 |   -0.9112 |   -0.8953 |
-#> |.....................|   -0.8489 |   -0.8466 |   -0.8655 |   -0.8776 |
-#> |.....................|   -0.8755 |   -0.8654 |   -0.8678 |   -0.8672 |
-#> |    U|     467.99742 |     93.25 |    -5.400 |   -0.9900 |   -0.1999 |
-#> |.....................|     2.100 |     2.004 |     1.201 |    0.7526 |
-#> |.....................|    0.8742 |     1.192 |     1.095 |     1.129 |
-#> |    X|     467.99742 |     93.25 |  0.004515 |    0.2709 |    0.8188 |
-#> |.....................|     8.168 |     2.004 |     1.201 |    0.7526 |
-#> |.....................|    0.8742 |     1.192 |     1.095 |     1.129 |
-#> |    F| Forward Diff. |    -98.28 |     1.929 |   -0.4044 |   -0.4503 |
-#> |.....................|    -1.484 |    -29.27 |    -9.987 |     8.922 |
-#> |.....................|     9.417 |    -11.79 |    -9.521 |    -8.343 |
-#> |    5|     467.67344 |    0.9967 |    -1.000 |   -0.9112 |   -0.8953 |
-#> |.....................|   -0.8488 |   -0.8452 |   -0.8651 |   -0.8780 |
-#> |.....................|   -0.8760 |   -0.8648 |   -0.8673 |   -0.8668 |
-#> |    U|     467.67344 |     93.69 |    -5.400 |   -0.9899 |   -0.1999 |
-#> |.....................|     2.100 |     2.006 |     1.201 |    0.7523 |
-#> |.....................|    0.8738 |     1.192 |     1.095 |     1.129 |
-#> |    X|     467.67344 |     93.69 |  0.004515 |    0.2709 |    0.8188 |
-#> |.....................|     8.168 |     2.006 |     1.201 |    0.7523 |
-#> |.....................|    0.8738 |     1.192 |     1.095 |     1.129 |
-#> |    F| Forward Diff. |    -11.92 |     1.963 |   -0.3242 |   -0.4184 |
-#> |.....................|    -1.350 |    -28.16 |    -10.02 |     8.541 |
-#> |.....................|     8.305 |    -11.80 |    -9.512 |    -8.408 |
-#> |    6|     467.50396 |    0.9983 |    -1.001 |   -0.9112 |   -0.8952 |
-#> |.....................|   -0.8487 |   -0.8416 |   -0.8638 |   -0.8791 |
-#> |.....................|   -0.8771 |   -0.8633 |   -0.8661 |   -0.8658 |
-#> |    U|     467.50396 |     93.84 |    -5.401 |   -0.9899 |   -0.1999 |
-#> |.....................|     2.100 |     2.010 |     1.202 |    0.7514 |
-#> |.....................|    0.8729 |     1.194 |     1.097 |     1.130 |
-#> |    X|     467.50396 |     93.84 |  0.004514 |    0.2709 |    0.8188 |
-#> |.....................|     8.170 |     2.010 |     1.202 |    0.7514 |
-#> |.....................|    0.8729 |     1.194 |     1.097 |     1.130 |
-#> |    7|     467.27231 |     1.003 |    -1.001 |   -0.9110 |   -0.8951 |
-#> |.....................|   -0.8481 |   -0.8306 |   -0.8599 |   -0.8825 |
-#> |.....................|   -0.8803 |   -0.8587 |   -0.8624 |   -0.8625 |
-#> |    U|     467.27231 |     94.27 |    -5.401 |   -0.9898 |   -0.1997 |
-#> |.....................|     2.101 |     2.021 |     1.204 |    0.7489 |
-#> |.....................|    0.8700 |     1.200 |     1.101 |     1.134 |
-#> |    X|     467.27231 |     94.27 |  0.004510 |    0.2710 |    0.8190 |
-#> |.....................|     8.174 |     2.021 |     1.204 |    0.7489 |
-#> |.....................|    0.8700 |     1.200 |     1.101 |     1.134 |
-#> |    F| Forward Diff. |     101.6 |     1.991 |   -0.1997 |   -0.3688 |
-#> |.....................|    -1.177 |    -25.72 |    -9.853 |     9.249 |
-#> |.....................|     8.335 |    -11.58 |    -9.288 |    -8.277 |
-#> |    8|     466.36087 |    0.9961 |    -1.002 |   -0.9109 |   -0.8949 |
-#> |.....................|   -0.8474 |   -0.8165 |   -0.8547 |   -0.8873 |
-#> |.....................|   -0.8853 |   -0.8526 |   -0.8575 |   -0.8582 |
-#> |    U|     466.36087 |     93.63 |    -5.402 |   -0.9896 |   -0.1995 |
-#> |.....................|     2.102 |     2.035 |     1.207 |    0.7453 |
-#> |.....................|    0.8657 |     1.207 |     1.106 |     1.139 |
-#> |    X|     466.36087 |     93.63 |  0.004506 |    0.2710 |    0.8191 |
-#> |.....................|     8.180 |     2.035 |     1.207 |    0.7453 |
-#> |.....................|    0.8657 |     1.207 |     1.106 |     1.139 |
-#> |    F| Forward Diff. |    -21.78 |     1.909 |   -0.3215 |   -0.4291 |
-#> |.....................|    -1.401 |    -25.38 |    -9.315 |     7.655 |
-#> |.....................|     10.17 |    -11.26 |    -9.035 |    -7.894 |
-#> |    9|     465.79764 |     1.000 |    -1.004 |   -0.9107 |   -0.8946 |
-#> |.....................|   -0.8467 |   -0.8024 |   -0.8495 |   -0.8920 |
-#> |.....................|   -0.8917 |   -0.8462 |   -0.8524 |   -0.8537 |
-#> |    U|     465.79764 |     94.04 |    -5.404 |   -0.9895 |   -0.1993 |
-#> |.....................|     2.102 |     2.049 |     1.211 |    0.7417 |
-#> |.....................|    0.8600 |     1.214 |     1.112 |     1.144 |
-#> |    X|     465.79764 |     94.04 |  0.004501 |    0.2710 |    0.8193 |
-#> |.....................|     8.186 |     2.049 |     1.211 |    0.7417 |
-#> |.....................|    0.8600 |     1.214 |     1.112 |     1.144 |
-#> |    F| Forward Diff. |     54.81 |     1.910 |   -0.2489 |   -0.4009 |
-#> |.....................|    -1.285 |    -22.17 |    -8.389 |     8.020 |
-#> |.....................|     7.340 |    -11.02 |    -8.786 |    -7.720 |
-#> |   10|     465.18897 |    0.9945 |    -1.005 |   -0.9105 |   -0.8943 |
-#> |.....................|   -0.8457 |   -0.7893 |   -0.8445 |   -0.8971 |
-#> |.....................|   -0.8975 |   -0.8390 |   -0.8467 |   -0.8487 |
-#> |    U|     465.18897 |     93.48 |    -5.405 |   -0.9893 |   -0.1990 |
-#> |.....................|     2.103 |     2.062 |     1.214 |    0.7379 |
-#> |.....................|    0.8549 |     1.223 |     1.118 |     1.149 |
-#> |    X|     465.18897 |     93.48 |  0.004495 |    0.2711 |    0.8196 |
-#> |.....................|     8.194 |     2.062 |     1.214 |    0.7379 |
-#> |.....................|    0.8549 |     1.223 |     1.118 |     1.149 |
-#> |    F| Forward Diff. |    -47.52 |     1.834 |   -0.3684 |   -0.4503 |
-#> |.....................|    -1.489 |    -22.39 |    -7.996 |     7.294 |
-#> |.....................|     9.249 |    -10.90 |    -8.741 |    -7.575 |
-#> |   11|     464.56229 |    0.9983 |    -1.006 |   -0.9102 |   -0.8940 |
-#> |.....................|   -0.8445 |   -0.7772 |   -0.8401 |   -0.9030 |
-#> |.....................|   -0.9029 |   -0.8305 |   -0.8400 |   -0.8430 |
-#> |    U|     464.56229 |     93.84 |    -5.406 |   -0.9890 |   -0.1986 |
-#> |.....................|     2.105 |     2.074 |     1.216 |    0.7334 |
-#> |.....................|    0.8503 |     1.233 |     1.125 |     1.156 |
-#> |    X|     464.56229 |     93.84 |  0.004488 |    0.2711 |    0.8199 |
-#> |.....................|     8.204 |     2.074 |     1.216 |    0.7334 |
-#> |.....................|    0.8503 |     1.233 |     1.125 |     1.156 |
-#> |   12|     463.71730 |    0.9982 |    -1.009 |   -0.9098 |   -0.8933 |
-#> |.....................|   -0.8424 |   -0.7583 |   -0.8332 |   -0.9128 |
-#> |.....................|   -0.9112 |   -0.8167 |   -0.8291 |   -0.8337 |
-#> |    U|      463.7173 |     93.83 |    -5.409 |   -0.9885 |   -0.1980 |
-#> |.....................|     2.107 |     2.093 |     1.220 |    0.7260 |
-#> |.....................|    0.8430 |     1.249 |     1.137 |     1.166 |
-#> |    X|      463.7173 |     93.83 |  0.004478 |    0.2712 |    0.8204 |
-#> |.....................|     8.221 |     2.093 |     1.220 |    0.7260 |
-#> |.....................|    0.8430 |     1.249 |     1.137 |     1.166 |
-#> |   13|     461.03699 |    0.9978 |    -1.018 |   -0.9080 |   -0.8909 |
-#> |.....................|   -0.8343 |   -0.6839 |   -0.8059 |   -0.9516 |
-#> |.....................|   -0.9441 |   -0.7622 |   -0.7862 |   -0.7969 |
-#> |    U|     461.03699 |     93.79 |    -5.418 |   -0.9868 |   -0.1955 |
-#> |.....................|     2.115 |     2.167 |     1.237 |    0.6968 |
-#> |.....................|    0.8141 |     1.314 |     1.184 |     1.208 |
-#> |    X|     461.03699 |     93.79 |  0.004435 |    0.2716 |    0.8224 |
-#> |.....................|     8.288 |     2.167 |     1.237 |    0.6968 |
-#> |.....................|    0.8141 |     1.314 |     1.184 |     1.208 |
-#> |   14|     458.83693 |    0.9972 |    -1.033 |   -0.9052 |   -0.8871 |
-#> |.....................|   -0.8218 |   -0.5692 |   -0.7639 |    -1.011 |
-#> |.....................|   -0.9948 |   -0.6782 |   -0.7201 |   -0.7403 |
-#> |    U|     458.83693 |     93.74 |    -5.433 |   -0.9840 |   -0.1917 |
-#> |.....................|     2.127 |     2.282 |     1.262 |    0.6519 |
-#> |.....................|    0.7697 |     1.414 |     1.256 |     1.272 |
-#> |    X|     458.83693 |     93.74 |  0.004371 |    0.2721 |    0.8255 |
-#> |.....................|     8.393 |     2.282 |     1.262 |    0.6519 |
-#> |.....................|    0.7697 |     1.414 |     1.256 |     1.272 |
-#> |    F| Forward Diff. |   0.05416 |     1.397 |   -0.2200 |   -0.5344 |
-#> |.....................|    -1.585 |    -3.387 |    -1.306 |   -0.2250 |
-#> |.....................|     1.392 |    -3.452 |    -2.065 |    -1.405 |
-#> |   15|     459.30045 |    0.9957 |    -1.166 |   -0.8845 |   -0.8313 |
-#> |.....................|   -0.6584 |   -0.5528 |   -0.7505 |   -0.8569 |
-#> |.....................|    -1.017 |   -0.4560 |   -0.6245 |   -0.7036 |
-#> |    U|     459.30045 |     93.60 |    -5.566 |   -0.9635 |   -0.1360 |
-#> |.....................|     2.291 |     2.298 |     1.270 |    0.7682 |
-#> |.....................|    0.7505 |     1.678 |     1.361 |     1.313 |
-#> |    X|     459.30045 |     93.60 |  0.003827 |    0.2762 |    0.8729 |
-#> |.....................|     9.881 |     2.298 |     1.270 |    0.7682 |
-#> |.....................|    0.7505 |     1.678 |     1.361 |     1.313 |
-#> |   16|     458.36319 |    0.9960 |    -1.071 |   -0.8992 |   -0.8719 |
-#> |.....................|   -0.7770 |   -0.5045 |   -0.7383 |   -0.9927 |
-#> |.....................|    -1.023 |   -0.5931 |   -0.6727 |   -0.7107 |
-#> |    U|     458.36319 |     93.63 |    -5.471 |   -0.9780 |   -0.1766 |
-#> |.....................|     2.172 |     2.347 |     1.277 |    0.6658 |
-#> |.....................|    0.7452 |     1.515 |     1.308 |     1.305 |
-#> |    X|     458.36319 |     93.63 |  0.004206 |    0.2733 |    0.8381 |
-#> |.....................|     8.777 |     2.347 |     1.277 |    0.6658 |
-#> |.....................|    0.7452 |     1.515 |     1.308 |     1.305 |
-#> |    F| Forward Diff. |    -12.30 |     1.214 |   0.06343 |   -0.2616 |
-#> |.....................|   -0.6069 |   0.08029 |    0.4273 |   0.07297 |
-#> |.....................|   -0.3937 |    0.3470 |    0.5201 |   0.09241 |
-#> |   17|     458.37724 |    0.9977 |    -1.183 |   -0.9046 |   -0.8476 |
-#> |.....................|   -0.7196 |   -0.4765 |   -0.7567 |    -1.014 |
-#> |.....................|   -0.9850 |   -0.5955 |   -0.6985 |   -0.7030 |
-#> |    U|     458.37724 |     93.79 |    -5.583 |   -0.9834 |   -0.1522 |
-#> |.....................|     2.229 |     2.375 |     1.266 |    0.6497 |
-#> |.....................|    0.7783 |     1.513 |     1.280 |     1.314 |
-#> |    X|     458.37724 |     93.79 |  0.003762 |    0.2722 |    0.8588 |
-#> |.....................|     9.295 |     2.375 |     1.266 |    0.6497 |
-#> |.....................|    0.7783 |     1.513 |     1.280 |     1.314 |
-#> |   18|     458.32800 |    0.9976 |    -1.124 |   -0.9017 |   -0.8605 |
-#> |.....................|   -0.7499 |   -0.4913 |   -0.7470 |    -1.003 |
-#> |.....................|    -1.005 |   -0.5943 |   -0.6849 |   -0.7071 |
-#> |    U|       458.328 |     93.78 |    -5.524 |   -0.9806 |   -0.1651 |
-#> |.....................|     2.199 |     2.360 |     1.272 |    0.6583 |
-#> |.....................|    0.7608 |     1.514 |     1.295 |     1.309 |
-#> |    X|       458.328 |     93.78 |  0.003990 |    0.2728 |    0.8478 |
-#> |.....................|     9.017 |     2.360 |     1.272 |    0.6583 |
-#> |.....................|    0.7608 |     1.514 |     1.295 |     1.309 |
-#> |    F| Forward Diff. |     9.757 |     1.093 |  -0.06310 |   0.02237 |
-#> |.....................|   0.09811 |    0.3115 |   -0.3381 |   -0.2098 |
-#> |.....................|    0.8196 |    0.7052 |   0.04425 |    0.2610 |
-#> |   19|     458.25889 |    0.9968 |    -1.183 |   -0.9011 |   -0.8543 |
-#> |.....................|   -0.7363 |   -0.4871 |   -0.7422 |    -1.003 |
-#> |.....................|    -1.023 |   -0.6115 |   -0.6911 |   -0.7106 |
-#> |    U|     458.25889 |     93.70 |    -5.583 |   -0.9799 |   -0.1589 |
-#> |.....................|     2.213 |     2.364 |     1.275 |    0.6583 |
-#> |.....................|    0.7450 |     1.494 |     1.288 |     1.305 |
-#> |    X|     458.25889 |     93.70 |  0.003760 |    0.2729 |    0.8531 |
-#> |.....................|     9.141 |     2.364 |     1.275 |    0.6583 |
-#> |.....................|    0.7450 |     1.494 |     1.288 |     1.305 |
-#> |    F| Forward Diff. |   -0.6125 |    0.8824 |  -0.01905 |    0.1697 |
-#> |.....................|    0.4368 |    0.4743 |   0.05191 |   -0.6440 |
-#> |.....................|   -0.4868 |   -0.9136 |   -0.3225 |  -0.06220 |
-#> |   20|     458.18570 |    0.9978 |    -1.246 |   -0.9006 |   -0.8585 |
-#> |.....................|   -0.7495 |   -0.4978 |   -0.7385 |   -0.9895 |
-#> |.....................|    -1.024 |   -0.6046 |   -0.6874 |   -0.7124 |
-#> |    U|      458.1857 |     93.79 |    -5.646 |   -0.9794 |   -0.1632 |
-#> |.....................|     2.200 |     2.353 |     1.277 |    0.6683 |
-#> |.....................|    0.7440 |     1.502 |     1.292 |     1.303 |
-#> |    X|      458.1857 |     93.79 |  0.003532 |    0.2730 |    0.8495 |
-#> |.....................|     9.022 |     2.353 |     1.277 |    0.6683 |
-#> |.....................|    0.7440 |     1.502 |     1.292 |     1.303 |
-#> |   21|     458.13464 |    0.9963 |    -1.435 |   -0.8992 |   -0.8705 |
-#> |.....................|   -0.7875 |   -0.5278 |   -0.7264 |   -0.9531 |
-#> |.....................|    -1.031 |   -0.5901 |   -0.6784 |   -0.7184 |
-#> |    U|     458.13464 |     93.65 |    -5.835 |   -0.9781 |   -0.1751 |
-#> |.....................|     2.162 |     2.323 |     1.284 |    0.6957 |
-#> |.....................|    0.7378 |     1.519 |     1.302 |     1.296 |
-#> |    X|     458.13464 |     93.65 |  0.002922 |    0.2733 |    0.8394 |
-#> |.....................|     8.685 |     2.323 |     1.284 |    0.6957 |
-#> |.....................|    0.7378 |     1.519 |     1.302 |     1.296 |
-#> |    F| Forward Diff. |    -15.15 |    0.2290 |    0.2476 |   -0.1455 |
-#> |.....................|   -0.7111 |    -1.138 |    0.8895 |     1.880 |
-#> |.....................|    -1.837 |    0.2029 |    0.3485 |   -0.6531 |
-#> |   22|     458.67841 |    0.9992 |    -1.651 |   -0.9027 |   -0.9245 |
-#> |.....................|   -0.8733 |   -0.5209 |   -0.7232 |    -1.036 |
-#> |.....................|    -1.001 |   -0.6164 |   -0.6125 |   -0.6771 |
-#> |    U|     458.67841 |     93.92 |    -6.051 |   -0.9815 |   -0.2291 |
-#> |.....................|     2.076 |     2.330 |     1.286 |    0.6333 |
-#> |.....................|    0.7647 |     1.488 |     1.374 |     1.343 |
-#> |    X|     458.67841 |     93.92 |  0.002355 |    0.2726 |    0.7952 |
-#> |.....................|     7.971 |     2.330 |     1.286 |    0.6333 |
-#> |.....................|    0.7647 |     1.488 |     1.374 |     1.343 |
-#> |   23|     458.25487 |     1.002 |    -1.469 |   -0.8998 |   -0.8789 |
-#> |.....................|   -0.8006 |   -0.5263 |   -0.7262 |   -0.9666 |
-#> |.....................|    -1.026 |   -0.5942 |   -0.6683 |   -0.7117 |
-#> |    U|     458.25487 |     94.17 |    -5.869 |   -0.9787 |   -0.1835 |
-#> |.....................|     2.148 |     2.325 |     1.285 |    0.6855 |
-#> |.....................|    0.7425 |     1.514 |     1.313 |     1.304 |
-#> |    X|     458.25487 |     94.17 |  0.002825 |    0.2732 |    0.8324 |
-#> |.....................|     8.572 |     2.325 |     1.285 |    0.6855 |
-#> |.....................|    0.7425 |     1.514 |     1.313 |     1.304 |
-#> |   24|     458.28425 |     1.002 |    -1.442 |   -0.8994 |   -0.8721 |
-#> |.....................|   -0.7899 |   -0.5271 |   -0.7267 |   -0.9564 |
-#> |.....................|    -1.030 |   -0.5910 |   -0.6765 |   -0.7168 |
-#> |    U|     458.28425 |     94.21 |    -5.842 |   -0.9783 |   -0.1768 |
-#> |.....................|     2.159 |     2.324 |     1.284 |    0.6932 |
-#> |.....................|    0.7392 |     1.518 |     1.304 |     1.298 |
-#> |    X|     458.28425 |     94.21 |  0.002902 |    0.2732 |    0.8380 |
-#> |.....................|     8.664 |     2.324 |     1.284 |    0.6932 |
-#> |.....................|    0.7392 |     1.518 |     1.304 |     1.298 |
-#> |   25|     458.13208 |    0.9983 |    -1.435 |   -0.8993 |   -0.8705 |
-#> |.....................|   -0.7874 |   -0.5276 |   -0.7266 |   -0.9533 |
-#> |.....................|    -1.031 |   -0.5901 |   -0.6785 |   -0.7183 |
-#> |    U|     458.13208 |     93.84 |    -5.835 |   -0.9781 |   -0.1751 |
-#> |.....................|     2.162 |     2.323 |     1.284 |    0.6955 |
-#> |.....................|    0.7380 |     1.519 |     1.302 |     1.296 |
-#> |    X|     458.13208 |     93.84 |  0.002922 |    0.2733 |    0.8394 |
-#> |.....................|     8.686 |     2.323 |     1.284 |    0.6955 |
-#> |.....................|    0.7380 |     1.519 |     1.302 |     1.296 |
-#> |    F| Forward Diff. |     13.75 |    0.2391 |    0.3431 |   -0.1129 |
-#> |.....................|   -0.6079 |    -1.684 |    0.2301 |     1.587 |
-#> |.....................|    0.9924 |   -0.4675 |    0.3927 |   -0.7567 |
-#> |   26|     458.12484 |    0.9973 |    -1.435 |   -0.8993 |   -0.8705 |
-#> |.....................|   -0.7874 |   -0.5275 |   -0.7266 |   -0.9535 |
-#> |.....................|    -1.031 |   -0.5900 |   -0.6785 |   -0.7182 |
-#> |    U|     458.12484 |     93.75 |    -5.835 |   -0.9782 |   -0.1751 |
-#> |.....................|     2.162 |     2.324 |     1.284 |    0.6954 |
-#> |.....................|    0.7379 |     1.519 |     1.302 |     1.297 |
-#> |    X|     458.12484 |     93.75 |  0.002922 |    0.2733 |    0.8394 |
-#> |.....................|     8.686 |     2.324 |     1.284 |    0.6954 |
-#> |.....................|    0.7379 |     1.519 |     1.302 |     1.297 |
-#> |    F| Forward Diff. |   -0.4576 |    0.2336 |    0.2904 |   -0.1274 |
-#> |.....................|   -0.6585 |    -1.014 |    0.9040 |     1.932 |
-#> |.....................|    -1.695 |    0.2950 |    0.3980 |   -0.7211 |
-#> |   27|     458.12349 |    0.9975 |    -1.436 |   -0.8994 |   -0.8704 |
-#> |.....................|   -0.7872 |   -0.5272 |   -0.7269 |   -0.9542 |
-#> |.....................|    -1.031 |   -0.5901 |   -0.6787 |   -0.7180 |
-#> |    U|     458.12349 |     93.76 |    -5.836 |   -0.9783 |   -0.1751 |
-#> |.....................|     2.162 |     2.324 |     1.284 |    0.6949 |
-#> |.....................|    0.7384 |     1.519 |     1.302 |     1.297 |
-#> |    X|     458.12349 |     93.76 |  0.002922 |    0.2732 |    0.8394 |
-#> |.....................|     8.688 |     2.324 |     1.284 |    0.6949 |
-#> |.....................|    0.7384 |     1.519 |     1.302 |     1.297 |
-#> |    F| Forward Diff. |     1.734 |    0.2328 |    0.2907 |   -0.1244 |
-#> |.....................|   -0.6480 |   -0.5259 |     1.203 |     2.086 |
-#> |.....................|    -1.687 |    0.2714 |    0.3976 |   -0.7167 |
-#> |   28|     458.12069 |    0.9972 |    -1.436 |   -0.8995 |   -0.8704 |
-#> |.....................|   -0.7868 |   -0.5270 |   -0.7278 |   -0.9557 |
-#> |.....................|    -1.030 |   -0.5902 |   -0.6785 |   -0.7174 |
-#> |    U|     458.12069 |     93.74 |    -5.836 |   -0.9784 |   -0.1750 |
-#> |.....................|     2.162 |     2.324 |     1.284 |    0.6937 |
-#> |.....................|    0.7392 |     1.519 |     1.302 |     1.297 |
-#> |    X|     458.12069 |     93.74 |  0.002921 |    0.2732 |    0.8394 |
-#> |.....................|     8.691 |     2.324 |     1.284 |    0.6937 |
-#> |.....................|    0.7392 |     1.519 |     1.302 |     1.297 |
-#> |    F| Forward Diff. |    -1.995 |    0.2265 |    0.2648 |   -0.1319 |
-#> |.....................|   -0.6577 |    -1.056 |    0.5532 |     1.629 |
-#> |.....................|   -0.4851 |    0.2582 |    0.3806 |   -0.6784 |
-#> |   29|     458.12793 |    0.9986 |    -1.436 |   -0.8997 |   -0.8703 |
-#> |.....................|   -0.7863 |   -0.5263 |   -0.7282 |   -0.9568 |
-#> |.....................|    -1.029 |   -0.5904 |   -0.6788 |   -0.7169 |
-#> |    U|     458.12793 |     93.87 |    -5.836 |   -0.9785 |   -0.1749 |
-#> |.....................|     2.163 |     2.325 |     1.283 |    0.6929 |
-#> |.....................|    0.7395 |     1.519 |     1.302 |     1.298 |
-#> |    X|     458.12793 |     93.87 |  0.002920 |    0.2732 |    0.8395 |
-#> |.....................|     8.695 |     2.325 |     1.283 |    0.6929 |
-#> |.....................|    0.7395 |     1.519 |     1.302 |     1.298 |
-#> |   30|     458.12002 |    0.9975 |    -1.436 |   -0.8996 |   -0.8704 |
-#> |.....................|   -0.7866 |   -0.5269 |   -0.7279 |   -0.9559 |
-#> |.....................|    -1.030 |   -0.5903 |   -0.6786 |   -0.7173 |
-#> |    U|     458.12002 |     93.77 |    -5.836 |   -0.9784 |   -0.1750 |
-#> |.....................|     2.162 |     2.324 |     1.284 |    0.6935 |
-#> |.....................|    0.7392 |     1.519 |     1.302 |     1.298 |
-#> |    X|     458.12002 |     93.77 |  0.002921 |    0.2732 |    0.8395 |
-#> |.....................|     8.692 |     2.324 |     1.284 |    0.6935 |
-#> |.....................|    0.7392 |     1.519 |     1.302 |     1.298 |
-#> |    F| Forward Diff. |     2.647 |    0.2293 |    0.2815 |   -0.1267 |
-#> |.....................|   -0.6372 |   -0.9129 |    0.8290 |     1.823 |
-#> |.....................|    -1.624 |    0.2659 |    0.4184 |   -0.6478 |
-#> |   31|     458.11922 |    0.9973 |    -1.436 |   -0.8996 |   -0.8704 |
-#> |.....................|   -0.7866 |   -0.5268 |   -0.7280 |   -0.9563 |
-#> |.....................|    -1.029 |   -0.5903 |   -0.6786 |   -0.7171 |
-#> |    U|     458.11922 |     93.74 |    -5.836 |   -0.9784 |   -0.1750 |
-#> |.....................|     2.163 |     2.324 |     1.284 |    0.6933 |
-#> |.....................|    0.7394 |     1.519 |     1.302 |     1.298 |
-#> |    X|     458.11922 |     93.74 |  0.002920 |    0.2732 |    0.8395 |
-#> |.....................|     8.693 |     2.324 |     1.284 |    0.6933 |
-#> |.....................|    0.7394 |     1.519 |     1.302 |     1.298 |
-#> |    F| Forward Diff. |   -0.8024 |    0.2274 |    0.2665 |   -0.1307 |
-#> |.....................|   -0.6475 |    -1.019 |    0.5594 |     1.618 |
-#> |.....................|    -1.681 |    0.3232 |    0.3907 |   -0.6658 |
-#> |   32|     458.11869 |    0.9974 |    -1.436 |   -0.8996 |   -0.8703 |
-#> |.....................|   -0.7864 |   -0.5266 |   -0.7281 |   -0.9565 |
-#> |.....................|    -1.029 |   -0.5904 |   -0.6787 |   -0.7170 |
-#> |    U|     458.11869 |     93.76 |    -5.836 |   -0.9785 |   -0.1750 |
-#> |.....................|     2.163 |     2.324 |     1.283 |    0.6931 |
-#> |.....................|    0.7397 |     1.519 |     1.302 |     1.298 |
-#> |    X|     458.11869 |     93.76 |  0.002920 |    0.2732 |    0.8395 |
-#> |.....................|     8.694 |     2.324 |     1.283 |    0.6931 |
-#> |.....................|    0.7397 |     1.519 |     1.302 |     1.298 |
-#> |    F| Forward Diff. |     1.112 |    0.2271 |    0.2694 |   -0.1286 |
-#> |.....................|   -0.6401 |    -1.529 |    0.3516 |     1.832 |
-#> |.....................|   -0.3653 |    0.2635 |    0.3774 |   -0.6589 |
-#> |   33|     458.11797 |    0.9972 |    -1.436 |   -0.8997 |   -0.8703 |
-#> |.....................|   -0.7863 |   -0.5263 |   -0.7282 |   -0.9569 |
-#> |.....................|    -1.029 |   -0.5904 |   -0.6788 |   -0.7169 |
-#> |    U|     458.11797 |     93.74 |    -5.836 |   -0.9785 |   -0.1749 |
-#> |.....................|     2.163 |     2.325 |     1.283 |    0.6928 |
-#> |.....................|    0.7397 |     1.519 |     1.302 |     1.298 |
-#> |    X|     458.11797 |     93.74 |  0.002920 |    0.2732 |    0.8395 |
-#> |.....................|     8.695 |     2.325 |     1.283 |    0.6928 |
-#> |.....................|    0.7397 |     1.519 |     1.302 |     1.298 |
-#> |    F| Forward Diff. |    -1.528 |    0.2260 |    0.2581 |   -0.1311 |
-#> |.....................|   -0.6478 |    -1.074 |    0.7096 |     1.705 |
-#> |.....................|    -1.609 |    0.2690 |    0.3809 |   -0.6419 |
-#> |   34|     458.11744 |    0.9975 |    -1.436 |   -0.8997 |   -0.8703 |
-#> |.....................|   -0.7862 |   -0.5262 |   -0.7283 |   -0.9571 |
-#> |.....................|    -1.029 |   -0.5904 |   -0.6788 |   -0.7168 |
-#> |    U|     458.11744 |     93.76 |    -5.836 |   -0.9786 |   -0.1749 |
-#> |.....................|     2.163 |     2.325 |     1.283 |    0.6926 |
-#> |.....................|    0.7399 |     1.519 |     1.302 |     1.298 |
-#> |    X|     458.11744 |     93.76 |  0.002920 |    0.2732 |    0.8395 |
-#> |.....................|     8.696 |     2.325 |     1.283 |    0.6926 |
-#> |.....................|    0.7399 |     1.519 |     1.302 |     1.298 |
-#> |    F| Forward Diff. |     1.737 |    0.2262 |    0.2659 |   -0.1276 |
-#> |.....................|   -0.6346 |   -0.9458 |    0.5100 |     1.567 |
-#> |.....................|    -1.640 |    0.3111 |    0.3526 |   -0.6225 |
-#> |   35|     458.11714 |    0.9972 |    -1.436 |   -0.8998 |   -0.8703 |
-#> |.....................|   -0.7861 |   -0.5260 |   -0.7284 |   -0.9574 |
-#> |.....................|    -1.029 |   -0.5905 |   -0.6789 |   -0.7167 |
-#> |    U|     458.11714 |     93.74 |    -5.836 |   -0.9786 |   -0.1749 |
-#> |.....................|     2.163 |     2.325 |     1.283 |    0.6924 |
-#> |.....................|    0.7402 |     1.519 |     1.302 |     1.298 |
-#> |    X|     458.11714 |     93.74 |  0.002920 |    0.2732 |    0.8395 |
-#> |.....................|     8.697 |     2.325 |     1.283 |    0.6924 |
-#> |.....................|    0.7402 |     1.519 |     1.302 |     1.298 |
-#> |    F| Forward Diff. |    -1.976 |    0.2241 |    0.2491 |   -0.1309 |
-#> |.....................|   -0.6467 |   -0.8649 |    0.8521 |     1.757 |
-#> |.....................|    -1.585 |    0.2641 |    0.3618 |   -0.6092 |
-#> |   36|     458.11663 |    0.9975 |    -1.436 |   -0.8998 |   -0.8703 |
-#> |.....................|   -0.7860 |   -0.5259 |   -0.7285 |   -0.9576 |
-#> |.....................|    -1.028 |   -0.5905 |   -0.6789 |   -0.7166 |
-#> |    U|     458.11663 |     93.76 |    -5.836 |   -0.9787 |   -0.1749 |
-#> |.....................|     2.163 |     2.325 |     1.283 |    0.6923 |
-#> |.....................|    0.7404 |     1.518 |     1.301 |     1.298 |
-#> |    X|     458.11663 |     93.76 |  0.002920 |    0.2732 |    0.8396 |
-#> |.....................|     8.698 |     2.325 |     1.283 |    0.6923 |
-#> |.....................|    0.7404 |     1.518 |     1.301 |     1.298 |
-#> |    F| Forward Diff. |     2.001 |    0.2249 |    0.2609 |   -0.1271 |
-#> |.....................|   -0.6310 |   -0.8317 |    0.8110 |     1.745 |
-#> |.....................|   -0.3162 |    0.2564 |    0.3586 |   -0.6097 |
-#> |   37|     458.11610 |    0.9971 |    -1.436 |   -0.8999 |   -0.8702 |
-#> |.....................|   -0.7859 |   -0.5258 |   -0.7286 |   -0.9579 |
-#> |.....................|    -1.028 |   -0.5906 |   -0.6790 |   -0.7165 |
-#> |    U|      458.1161 |     93.73 |    -5.836 |   -0.9787 |   -0.1749 |
-#> |.....................|     2.163 |     2.325 |     1.283 |    0.6920 |
-#> |.....................|    0.7404 |     1.518 |     1.301 |     1.298 |
-#> |    X|      458.1161 |     93.73 |  0.002920 |    0.2732 |    0.8396 |
-#> |.....................|     8.699 |     2.325 |     1.283 |    0.6920 |
-#> |.....................|    0.7404 |     1.518 |     1.301 |     1.298 |
-#> |    F| Forward Diff. |    -2.471 |    0.2228 |    0.2417 |   -0.1310 |
-#> |.....................|   -0.6447 |    -1.605 |  0.009434 |     1.531 |
-#> |.....................|    -1.615 |    0.2909 |    0.3664 |   -0.6093 |
-#> |   38|     458.11531 |    0.9974 |    -1.436 |   -0.8999 |   -0.8702 |
-#> |.....................|   -0.7859 |   -0.5256 |   -0.7287 |   -0.9582 |
-#> |.....................|    -1.028 |   -0.5905 |   -0.6791 |   -0.7164 |
-#> |    U|     458.11531 |     93.76 |    -5.836 |   -0.9788 |   -0.1749 |
-#> |.....................|     2.163 |     2.326 |     1.283 |    0.6918 |
-#> |.....................|    0.7405 |     1.518 |     1.301 |     1.299 |
-#> |    X|     458.11531 |     93.76 |  0.002919 |    0.2731 |    0.8396 |
-#> |.....................|     8.699 |     2.326 |     1.283 |    0.6918 |
-#> |.....................|    0.7405 |     1.518 |     1.301 |     1.299 |
-#> |    F| Forward Diff. |     1.540 |    0.2236 |    0.2522 |   -0.1268 |
-#> |.....................|   -0.6308 |   -0.9638 |    0.7239 |     1.714 |
-#> |.....................|    -1.540 |    0.2567 |    0.3599 |   -0.5942 |
-#> |   39|     458.11496 |    0.9972 |    -1.436 |   -0.8999 |   -0.8702 |
-#> |.....................|   -0.7858 |   -0.5254 |   -0.7288 |   -0.9585 |
-#> |.....................|    -1.028 |   -0.5906 |   -0.6791 |   -0.7163 |
-#> |    U|     458.11496 |     93.74 |    -5.836 |   -0.9788 |   -0.1748 |
-#> |.....................|     2.163 |     2.326 |     1.283 |    0.6916 |
-#> |.....................|    0.7408 |     1.518 |     1.301 |     1.299 |
-#> |    X|     458.11496 |     93.74 |  0.002919 |    0.2731 |    0.8396 |
-#> |.....................|     8.700 |     2.326 |     1.283 |    0.6916 |
-#> |.....................|    0.7408 |     1.518 |     1.301 |     1.299 |
-#> |    F| Forward Diff. |    -1.772 |    0.2217 |    0.2376 |   -0.1305 |
-#> |.....................|   -0.6412 |    -1.736 |    0.1210 |     1.307 |
-#> |.....................|    -1.540 |    0.2780 |    0.3483 |   -0.5916 |
-#> |   40|     458.11458 |    0.9975 |    -1.436 |   -0.9000 |   -0.8702 |
-#> |.....................|   -0.7857 |   -0.5252 |   -0.7289 |   -0.9587 |
-#> |.....................|    -1.028 |   -0.5906 |   -0.6792 |   -0.7163 |
-#> |    U|     458.11458 |     93.76 |    -5.836 |   -0.9788 |   -0.1748 |
-#> |.....................|     2.163 |     2.326 |     1.283 |    0.6915 |
-#> |.....................|    0.7410 |     1.518 |     1.301 |     1.299 |
-#> |    X|     458.11458 |     93.76 |  0.002919 |    0.2731 |    0.8396 |
-#> |.....................|     8.701 |     2.326 |     1.283 |    0.6915 |
-#> |.....................|    0.7410 |     1.518 |     1.301 |     1.299 |
-#> |    F| Forward Diff. |     1.896 |    0.2223 |    0.2476 |   -0.1262 |
-#> |.....................|   -0.6268 |   -0.4531 |    0.7600 |     1.698 |
-#> |.....................|    -1.483 |    0.2984 |    0.3374 |   -0.6006 |
-#> |   41|     458.11430 |    0.9972 |    -1.436 |   -0.9000 |   -0.8702 |
-#> |.....................|   -0.7856 |   -0.5251 |   -0.7290 |   -0.9589 |
-#> |.....................|    -1.027 |   -0.5907 |   -0.6792 |   -0.7162 |
-#> |    U|      458.1143 |     93.73 |    -5.836 |   -0.9789 |   -0.1748 |
-#> |.....................|     2.164 |     2.326 |     1.283 |    0.6913 |
-#> |.....................|    0.7412 |     1.518 |     1.301 |     1.299 |
-#> |    X|      458.1143 |     93.73 |  0.002919 |    0.2731 |    0.8396 |
-#> |.....................|     8.702 |     2.326 |     1.283 |    0.6913 |
-#> |.....................|    0.7412 |     1.518 |     1.301 |     1.299 |
-#> |    F| Forward Diff. |    -2.121 |    0.2201 |    0.2306 |   -0.1307 |
-#> |.....................|   -0.6392 |   -0.8820 |    0.4853 |     1.475 |
-#> |.....................|    -1.568 |    0.2856 |    0.3442 |   -0.5942 |
-#> |   42|     458.11392 |    0.9975 |    -1.437 |   -0.9001 |   -0.8702 |
-#> |.....................|   -0.7855 |   -0.5250 |   -0.7290 |   -0.9592 |
-#> |.....................|    -1.027 |   -0.5907 |   -0.6793 |   -0.7161 |
-#> |    U|     458.11392 |     93.76 |    -5.837 |   -0.9789 |   -0.1748 |
-#> |.....................|     2.164 |     2.326 |     1.283 |    0.6911 |
-#> |.....................|    0.7414 |     1.518 |     1.301 |     1.299 |
-#> |    X|     458.11392 |     93.76 |  0.002919 |    0.2731 |    0.8396 |
-#> |.....................|     8.702 |     2.326 |     1.283 |    0.6911 |
-#> |.....................|    0.7414 |     1.518 |     1.301 |     1.299 |
-#> |    F| Forward Diff. |     2.218 |    0.2203 |    0.2415 |   -0.1269 |
-#> |.....................|   -0.6242 |    -1.700 |   -0.1298 |     1.090 |
-#> |.....................|     1.097 |   -0.4639 |    0.3406 |   -0.5940 |
-#> |   43|     458.11292 |    0.9972 |    -1.437 |   -0.9001 |   -0.8702 |
-#> |.....................|   -0.7854 |   -0.5247 |   -0.7291 |   -0.9594 |
-#> |.....................|    -1.027 |   -0.5906 |   -0.6794 |   -0.7160 |
-#> |    U|     458.11292 |     93.74 |    -5.837 |   -0.9790 |   -0.1748 |
-#> |.....................|     2.164 |     2.326 |     1.283 |    0.6909 |
-#> |.....................|    0.7412 |     1.518 |     1.301 |     1.299 |
-#> |    X|     458.11292 |     93.74 |  0.002919 |    0.2731 |    0.8396 |
-#> |.....................|     8.703 |     2.326 |     1.283 |    0.6909 |
-#> |.....................|    0.7412 |     1.518 |     1.301 |     1.299 |
-#> |    F| Forward Diff. |    -1.114 |    0.2202 |    0.2288 |   -0.1307 |
-#> |.....................|   -0.6328 |   -0.7727 |    0.7964 |     1.664 |
-#> |.....................|   -0.2569 |    0.2827 |    0.3132 |   -0.5835 |
-#> |   44|     458.11219 |    0.9975 |    -1.437 |   -0.9002 |   -0.8701 |
-#> |.....................|   -0.7853 |   -0.5246 |   -0.7293 |   -0.9597 |
-#> |.....................|    -1.027 |   -0.5907 |   -0.6795 |   -0.7158 |
-#> |    U|     458.11219 |     93.76 |    -5.837 |   -0.9790 |   -0.1748 |
-#> |.....................|     2.164 |     2.327 |     1.283 |    0.6907 |
-#> |.....................|    0.7413 |     1.518 |     1.301 |     1.299 |
-#> |    X|     458.11219 |     93.76 |  0.002919 |    0.2731 |    0.8397 |
-#> |.....................|     8.704 |     2.327 |     1.283 |    0.6907 |
-#> |.....................|    0.7413 |     1.518 |     1.301 |     1.299 |
-#> |    F| Forward Diff. |     1.924 |    0.2207 |    0.2357 |   -0.1254 |
-#> |.....................|   -0.6202 |   -0.4451 |    0.8288 |     1.643 |
-#> |.....................|    -1.561 |    0.2786 |    0.3167 |   -0.5797 |
-#> |   45|     458.11161 |    0.9972 |    -1.437 |   -0.9002 |   -0.8701 |
-#> |.....................|   -0.7852 |   -0.5246 |   -0.7295 |   -0.9601 |
-#> |.....................|    -1.027 |   -0.5907 |   -0.6795 |   -0.7157 |
-#> |    U|     458.11161 |     93.74 |    -5.837 |   -0.9791 |   -0.1747 |
-#> |.....................|     2.164 |     2.327 |     1.283 |    0.6904 |
-#> |.....................|    0.7414 |     1.518 |     1.301 |     1.299 |
-#> |    X|     458.11161 |     93.74 |  0.002918 |    0.2731 |    0.8397 |
-#> |.....................|     8.705 |     2.327 |     1.283 |    0.6904 |
-#> |.....................|    0.7414 |     1.518 |     1.301 |     1.299 |
-#> |    F| Forward Diff. |    -1.221 |    0.2188 |    0.2217 |   -0.1291 |
-#> |.....................|   -0.6301 |    -1.629 |    0.1332 |     1.223 |
-#> |.....................|    -1.491 |    0.2969 |    0.3215 |   -0.5516 |
-#> |   46|     458.11130 |    0.9974 |    -1.437 |   -0.9003 |   -0.8701 |
-#> |.....................|   -0.7851 |   -0.5243 |   -0.7295 |   -0.9603 |
-#> |.....................|    -1.027 |   -0.5907 |   -0.6796 |   -0.7156 |
-#> |    U|      458.1113 |     93.76 |    -5.837 |   -0.9791 |   -0.1747 |
-#> |.....................|     2.164 |     2.327 |     1.283 |    0.6902 |
-#> |.....................|    0.7416 |     1.518 |     1.301 |     1.299 |
-#> |    X|      458.1113 |     93.76 |  0.002918 |    0.2731 |    0.8397 |
-#> |.....................|     8.706 |     2.327 |     1.283 |    0.6902 |
-#> |.....................|    0.7416 |     1.518 |     1.301 |     1.299 |
-#> |    F| Forward Diff. |     1.605 |    0.2188 |    0.2279 |   -0.1262 |
-#> |.....................|   -0.6191 |    -1.596 |    0.1216 |     1.254 |
-#> |.....................|     1.158 |   -0.4084 |    0.3005 |   -0.5648 |
-#> |   47|     458.11059 |    0.9972 |    -1.437 |   -0.9003 |   -0.8701 |
-#> |.....................|   -0.7850 |   -0.5240 |   -0.7295 |   -0.9605 |
-#> |.....................|    -1.027 |   -0.5906 |   -0.6796 |   -0.7155 |
-#> |    U|     458.11059 |     93.73 |    -5.837 |   -0.9791 |   -0.1747 |
-#> |.....................|     2.164 |     2.327 |     1.283 |    0.6901 |
-#> |.....................|    0.7415 |     1.518 |     1.301 |     1.300 |
-#> |    X|     458.11059 |     93.73 |  0.002918 |    0.2731 |    0.8397 |
-#> |.....................|     8.707 |     2.327 |     1.283 |    0.6901 |
-#> |.....................|    0.7415 |     1.518 |     1.301 |     1.300 |
-#> |    F| Forward Diff. |    -2.022 |    0.2179 |    0.2140 |   -0.1317 |
-#> |.....................|   -0.6294 |   -0.4112 |    0.8588 |     1.629 |
-#> |.....................|    -1.524 |    0.3410 |    0.3226 |   -0.5400 |
-#> |   48|     458.10995 |    0.9975 |    -1.437 |   -0.9003 |   -0.8701 |
-#> |.....................|   -0.7849 |   -0.5239 |   -0.7297 |   -0.9608 |
-#> |.....................|    -1.027 |   -0.5906 |   -0.6797 |   -0.7154 |
-#> |    U|     458.10995 |     93.76 |    -5.837 |   -0.9792 |   -0.1747 |
-#> |.....................|     2.164 |     2.327 |     1.283 |    0.6899 |
-#> |.....................|    0.7416 |     1.518 |     1.301 |     1.300 |
-#> |    X|     458.10995 |     93.76 |  0.002918 |    0.2731 |    0.8397 |
-#> |.....................|     8.708 |     2.327 |     1.283 |    0.6899 |
-#> |.....................|    0.7416 |     1.518 |     1.301 |     1.300 |
-#> |    F| Forward Diff. |     1.872 |    0.2188 |    0.2245 |   -0.1278 |
-#> |.....................|   -0.6141 |    -1.055 |    0.5121 |     1.433 |
-#> |.....................|    -1.504 |    0.3641 |    0.3235 |   -0.5302 |
-#> |   49|     458.10978 |    0.9972 |    -1.437 |   -0.9004 |   -0.8700 |
-#> |.....................|   -0.7848 |   -0.5238 |   -0.7297 |   -0.9610 |
-#> |.....................|    -1.027 |   -0.5907 |   -0.6797 |   -0.7153 |
-#> |    U|     458.10978 |     93.73 |    -5.837 |   -0.9792 |   -0.1747 |
-#> |.....................|     2.164 |     2.327 |     1.282 |    0.6897 |
-#> |.....................|    0.7418 |     1.518 |     1.301 |     1.300 |
-#> |    X|     458.10978 |     93.73 |  0.002918 |    0.2730 |    0.8397 |
-#> |.....................|     8.709 |     2.327 |     1.282 |    0.6897 |
-#> |.....................|    0.7418 |     1.518 |     1.301 |     1.300 |
-#> |    C| Central Diff. |    -2.410 |    0.2142 |    0.1743 |   -0.1457 |
-#> |.....................|   -0.6441 |   -0.7806 |    0.7426 |     1.188 |
-#> |.....................|  -0.06181 |   -0.3659 |    0.5158 |   -0.5913 |
-#> |   50|     458.10914 |    0.9975 |    -1.437 |   -0.9004 |   -0.8700 |
-#> |.....................|   -0.7847 |   -0.5236 |   -0.7299 |   -0.9612 |
-#> |.....................|    -1.027 |   -0.5906 |   -0.6798 |   -0.7152 |
-#> |    U|     458.10914 |     93.77 |    -5.837 |   -0.9792 |   -0.1747 |
-#> |.....................|     2.164 |     2.327 |     1.282 |    0.6895 |
-#> |.....................|    0.7418 |     1.518 |     1.300 |     1.300 |
-#> |    X|     458.10914 |     93.77 |  0.002918 |    0.2730 |    0.8397 |
-#> |.....................|     8.709 |     2.327 |     1.282 |    0.6895 |
-#> |.....................|    0.7418 |     1.518 |     1.300 |     1.300 |
-#> |    F| Forward Diff. |     2.690 |    0.2171 |    0.2203 |   -0.1291 |
-#> |.....................|   -0.6099 |   -0.7940 |    0.4528 |     1.377 |
-#> |.....................|    -1.452 |    0.2831 |    0.2911 |   -0.5300 |
-#> |   51|     458.10832 |    0.9972 |    -1.437 |   -0.9004 |   -0.8700 |
-#> |.....................|   -0.7846 |   -0.5235 |   -0.7300 |   -0.9615 |
-#> |.....................|    -1.027 |   -0.5905 |   -0.6799 |   -0.7151 |
-#> |    U|     458.10832 |     93.74 |    -5.837 |   -0.9793 |   -0.1747 |
-#> |.....................|     2.164 |     2.328 |     1.282 |    0.6893 |
-#> |.....................|    0.7418 |     1.518 |     1.300 |     1.300 |
-#> |    X|     458.10832 |     93.74 |  0.002918 |    0.2730 |    0.8397 |
-#> |.....................|     8.710 |     2.328 |     1.282 |    0.6893 |
-#> |.....................|    0.7418 |     1.518 |     1.300 |     1.300 |
-#> |    F| Forward Diff. |    -1.386 |    0.2164 |    0.2066 |   -0.1317 |
-#> |.....................|   -0.6210 |   -0.6390 |    0.8493 |     1.598 |
-#> |.....................|    -1.491 |    0.2964 |    0.2278 |   -0.4988 |
-#> |   52|     458.10801 |    0.9974 |    -1.437 |   -0.9005 |   -0.8700 |
-#> |.....................|   -0.7845 |   -0.5234 |   -0.7302 |   -0.9618 |
-#> |.....................|    -1.026 |   -0.5906 |   -0.6800 |   -0.7150 |
-#> |    U|     458.10801 |     93.76 |    -5.837 |   -0.9793 |   -0.1746 |
-#> |.....................|     2.165 |     2.328 |     1.282 |    0.6891 |
-#> |.....................|    0.7421 |     1.518 |     1.300 |     1.300 |
-#> |    X|     458.10801 |     93.76 |  0.002918 |    0.2730 |    0.8398 |
-#> |.....................|     8.711 |     2.328 |     1.282 |    0.6891 |
-#> |.....................|    0.7421 |     1.518 |     1.300 |     1.300 |
-#> |    F| Forward Diff. |     1.854 |    0.2167 |    0.2150 |   -0.1282 |
-#> |.....................|   -0.6083 |   -0.7461 |    0.7029 |     1.539 |
-#> |.....................|   -0.1981 |    0.2733 |    0.2717 |   -0.5257 |
-#> |   53|     458.10765 |    0.9971 |    -1.437 |   -0.9005 |   -0.8700 |
-#> |.....................|   -0.7844 |   -0.5232 |   -0.7303 |   -0.9621 |
-#> |.....................|    -1.026 |   -0.5906 |   -0.6800 |   -0.7149 |
-#> |    U|     458.10765 |     93.73 |    -5.837 |   -0.9794 |   -0.1746 |
-#> |.....................|     2.165 |     2.328 |     1.282 |    0.6889 |
-#> |.....................|    0.7421 |     1.518 |     1.300 |     1.300 |
-#> |    X|     458.10765 |     93.73 |  0.002917 |    0.2730 |    0.8398 |
-#> |.....................|     8.712 |     2.328 |     1.282 |    0.6889 |
-#> |.....................|    0.7421 |     1.518 |     1.300 |     1.300 |
-#> |    F| Forward Diff. |    -2.678 |    0.2148 |    0.1964 |   -0.1329 |
-#> |.....................|   -0.6222 |   -0.7140 |    0.5004 |     1.353 |
-#> |.....................|   -0.2647 |    0.3470 |    0.3026 |   -0.5041 |
-#> |   54|     458.10677 |    0.9974 |    -1.437 |   -0.9006 |   -0.8700 |
-#> |.....................|   -0.7843 |   -0.5231 |   -0.7305 |   -0.9624 |
-#> |.....................|    -1.026 |   -0.5907 |   -0.6801 |   -0.7148 |
-#> |    U|     458.10677 |     93.76 |    -5.837 |   -0.9794 |   -0.1746 |
-#> |.....................|     2.165 |     2.328 |     1.282 |    0.6887 |
-#> |.....................|    0.7421 |     1.518 |     1.300 |     1.300 |
-#> |    X|     458.10677 |     93.76 |  0.002917 |    0.2730 |    0.8398 |
-#> |.....................|     8.713 |     2.328 |     1.282 |    0.6887 |
-#> |.....................|    0.7421 |     1.518 |     1.300 |     1.300 |
-#> |    F| Forward Diff. |     1.911 |    0.2164 |    0.2105 |   -0.1281 |
-#> |.....................|   -0.6034 |   -0.7920 |    0.6471 |     1.488 |
-#> |.....................|   -0.2445 |    0.2110 |    0.2380 |   -0.4469 |
-#> |   55|     458.10609 |    0.9972 |    -1.437 |   -0.9006 |   -0.8700 |
-#> |.....................|   -0.7842 |   -0.5230 |   -0.7306 |   -0.9627 |
-#> |.....................|    -1.026 |   -0.5907 |   -0.6801 |   -0.7147 |
-#> |    U|     458.10609 |     93.74 |    -5.837 |   -0.9794 |   -0.1746 |
-#> |.....................|     2.165 |     2.328 |     1.282 |    0.6884 |
-#> |.....................|    0.7421 |     1.518 |     1.300 |     1.300 |
-#> |    X|     458.10609 |     93.74 |  0.002917 |    0.2730 |    0.8398 |
-#> |.....................|     8.714 |     2.328 |     1.282 |    0.6884 |
-#> |.....................|    0.7421 |     1.518 |     1.300 |     1.300 |
-#> |    F| Forward Diff. |    -1.589 |    0.2148 |    0.1951 |   -0.1322 |
-#> |.....................|   -0.6145 |   -0.8575 |    0.5942 |     1.427 |
-#> |.....................|    -1.492 |    0.2699 |    0.1872 |   -0.4796 |
-#> |   56|     458.10567 |    0.9974 |    -1.437 |   -0.9006 |   -0.8699 |
-#> |.....................|   -0.7841 |   -0.5228 |   -0.7308 |   -0.9630 |
-#> |.....................|    -1.026 |   -0.5907 |   -0.6801 |   -0.7146 |
-#> |    U|     458.10567 |     93.76 |    -5.837 |   -0.9795 |   -0.1746 |
-#> |.....................|     2.165 |     2.328 |     1.282 |    0.6882 |
-#> |.....................|    0.7422 |     1.518 |     1.300 |     1.301 |
-#> |    X|     458.10567 |     93.76 |  0.002917 |    0.2730 |    0.8398 |
-#> |.....................|     8.715 |     2.328 |     1.282 |    0.6882 |
-#> |.....................|    0.7422 |     1.518 |     1.300 |     1.301 |
-#> |    F| Forward Diff. |     1.760 |    0.2153 |    0.2043 |   -0.1283 |
-#> |.....................|   -0.6005 |   -0.7529 |    0.6292 |     1.454 |
-#> |.....................|   -0.2107 |    0.2534 |    0.2280 |   -0.4318 |
-#> |   57|     458.10540 |    0.9971 |    -1.437 |   -0.9007 |   -0.8699 |
-#> |.....................|   -0.7840 |   -0.5227 |   -0.7309 |   -0.9633 |
-#> |.....................|    -1.026 |   -0.5907 |   -0.6801 |   -0.7146 |
-#> |    U|      458.1054 |     93.73 |    -5.837 |   -0.9795 |   -0.1745 |
-#> |.....................|     2.165 |     2.328 |     1.282 |    0.6880 |
-#> |.....................|    0.7423 |     1.518 |     1.300 |     1.301 |
-#> |    X|      458.1054 |     93.73 |  0.002917 |    0.2730 |    0.8398 |
-#> |.....................|     8.716 |     2.328 |     1.282 |    0.6880 |
-#> |.....................|    0.7423 |     1.518 |     1.300 |     1.301 |
-#> |    F| Forward Diff. |    -2.789 |    0.2130 |    0.1850 |   -0.1339 |
-#> |.....................|   -0.6160 |   -0.6903 |    0.7130 |     1.481 |
-#> |.....................|   -0.1975 |    0.2824 |    0.2646 |   -0.4868 |
-#> |   58|     458.10444 |    0.9974 |    -1.437 |   -0.9007 |   -0.8699 |
-#> |.....................|   -0.7839 |   -0.5226 |   -0.7311 |   -0.9636 |
-#> |.....................|    -1.026 |   -0.5907 |   -0.6801 |   -0.7145 |
-#> |    U|     458.10444 |     93.76 |    -5.837 |   -0.9796 |   -0.1745 |
-#> |.....................|     2.165 |     2.329 |     1.282 |    0.6878 |
-#> |.....................|    0.7423 |     1.518 |     1.300 |     1.301 |
-#> |    X|     458.10444 |     93.76 |  0.002916 |    0.2730 |    0.8398 |
-#> |.....................|     8.717 |     2.329 |     1.282 |    0.6878 |
-#> |.....................|    0.7423 |     1.518 |     1.300 |     1.301 |
-#> |    F| Forward Diff. |     1.285 |    0.2143 |    0.1972 |   -0.1290 |
-#> |.....................|   -0.5987 |   -0.7355 |    0.6064 |     1.421 |
-#> |.....................|    -1.460 |    0.2526 |    0.2188 |   -0.4206 |
-#> |   59|     458.10435 |    0.9972 |    -1.437 |   -0.9008 |   -0.8699 |
-#> |.....................|   -0.7838 |   -0.5224 |   -0.7312 |   -0.9638 |
-#> |.....................|    -1.026 |   -0.5908 |   -0.6802 |   -0.7144 |
-#> |    U|     458.10435 |     93.73 |    -5.837 |   -0.9796 |   -0.1745 |
-#> |.....................|     2.165 |     2.329 |     1.282 |    0.6876 |
-#> |.....................|    0.7425 |     1.518 |     1.300 |     1.301 |
-#> |    X|     458.10435 |     93.73 |  0.002916 |    0.2730 |    0.8399 |
-#> |.....................|     8.718 |     2.329 |     1.282 |    0.6876 |
-#> |.....................|    0.7425 |     1.518 |     1.300 |     1.301 |
-#> |    C| Central Diff. |    -2.184 |    0.2097 |    0.1486 |   -0.1446 |
-#> |.....................|   -0.6255 |   -0.7028 |    0.6444 |     1.495 |
-#> |.....................|    -1.416 |    0.3010 |    0.4942 |   -0.5303 |
-#> |   60|     458.10393 |    0.9975 |    -1.438 |   -0.9008 |   -0.8699 |
-#> |.....................|   -0.7837 |   -0.5223 |   -0.7313 |   -0.9641 |
-#> |.....................|    -1.026 |   -0.5908 |   -0.6802 |   -0.7143 |
-#> |    U|     458.10393 |     93.76 |    -5.838 |   -0.9796 |   -0.1745 |
-#> |.....................|     2.165 |     2.329 |     1.282 |    0.6873 |
-#> |.....................|    0.7426 |     1.518 |     1.300 |     1.301 |
-#> |    X|     458.10393 |     93.76 |  0.002916 |    0.2730 |    0.8399 |
-#> |.....................|     8.718 |     2.329 |     1.282 |    0.6873 |
-#> |.....................|    0.7426 |     1.518 |     1.300 |     1.301 |
-#> |    F| Forward Diff. |     2.045 |    0.2119 |    0.1940 |   -0.1305 |
-#> |.....................|   -0.5955 |   -0.7252 |    0.6285 |     1.413 |
-#> |.....................|   -0.2070 |    0.2194 |    0.2208 |   -0.3980 |
-#> |   61|     458.10364 |    0.9971 |    -1.438 |   -0.9008 |   -0.8699 |
-#> |.....................|   -0.7836 |   -0.5222 |   -0.7314 |   -0.9644 |
-#> |.....................|    -1.026 |   -0.5908 |   -0.6803 |   -0.7142 |
-#> |    U|     458.10364 |     93.73 |    -5.838 |   -0.9796 |   -0.1745 |
-#> |.....................|     2.166 |     2.329 |     1.281 |    0.6871 |
-#> |.....................|    0.7427 |     1.518 |     1.300 |     1.301 |
-#> |    X|     458.10364 |     93.73 |  0.002916 |    0.2730 |    0.8399 |
-#> |.....................|     8.719 |     2.329 |     1.281 |    0.6871 |
-#> |.....................|    0.7427 |     1.518 |     1.300 |     1.301 |
-#> |    F| Forward Diff. |    -2.727 |    0.2108 |    0.1771 |   -0.1339 |
-#> |.....................|   -0.6094 |   -0.7304 |    0.6317 |     1.376 |
-#> |.....................|    -1.443 |    0.2644 |    0.2580 |   -0.4629 |
-#> |   62|     458.10286 |    0.9974 |    -1.438 |   -0.9008 |   -0.8699 |
-#> |.....................|   -0.7835 |   -0.5221 |   -0.7316 |   -0.9647 |
-#> |.....................|    -1.026 |   -0.5908 |   -0.6803 |   -0.7141 |
-#> |    U|     458.10286 |     93.75 |    -5.838 |   -0.9796 |   -0.1745 |
-#> |.....................|     2.166 |     2.329 |     1.281 |    0.6869 |
-#> |.....................|    0.7427 |     1.518 |     1.300 |     1.301 |
-#> |    X|     458.10286 |     93.75 |  0.002915 |    0.2730 |    0.8399 |
-#> |.....................|     8.720 |     2.329 |     1.281 |    0.6869 |
-#> |.....................|    0.7427 |     1.518 |     1.300 |     1.301 |
-#> |    F| Forward Diff. |     1.225 |    0.2118 |    0.1898 |   -0.1294 |
-#> |.....................|   -0.5932 |   -0.6493 |    0.6517 |     1.411 |
-#> |.....................|   -0.1402 |    0.3233 |    0.2428 |   -0.3732 |
-#> |   63|     458.10253 |    0.9971 |    -1.438 |   -0.9009 |   -0.8698 |
-#> |.....................|   -0.7834 |   -0.5219 |   -0.7318 |   -0.9650 |
-#> |.....................|    -1.026 |   -0.5909 |   -0.6803 |   -0.7141 |
-#> |    U|     458.10253 |     93.73 |    -5.838 |   -0.9797 |   -0.1745 |
-#> |.....................|     2.166 |     2.329 |     1.281 |    0.6867 |
-#> |.....................|    0.7428 |     1.518 |     1.300 |     1.301 |
-#> |    X|     458.10253 |     93.73 |  0.002915 |    0.2730 |    0.8399 |
-#> |.....................|     8.721 |     2.329 |     1.281 |    0.6867 |
-#> |.....................|    0.7428 |     1.518 |     1.300 |     1.301 |
-#> |    F| Forward Diff. |    -2.449 |    0.2099 |    0.1736 |   -0.1338 |
-#> |.....................|   -0.6049 |   -0.7015 |    0.6330 |     1.384 |
-#> |.....................|   -0.1863 |    0.2615 |    0.2563 |   -0.4532 |
-#> |   64|     458.10167 |    0.9974 |    -1.438 |   -0.9009 |   -0.8698 |
-#> |.....................|   -0.7832 |   -0.5218 |   -0.7320 |   -0.9653 |
-#> |.....................|    -1.026 |   -0.5909 |   -0.6804 |   -0.7140 |
-#> |    U|     458.10167 |     93.76 |    -5.838 |   -0.9797 |   -0.1744 |
-#> |.....................|     2.166 |     2.329 |     1.281 |    0.6864 |
-#> |.....................|    0.7427 |     1.518 |     1.300 |     1.301 |
-#> |    X|     458.10167 |     93.76 |  0.002915 |    0.2729 |    0.8399 |
-#> |.....................|     8.722 |     2.329 |     1.281 |    0.6864 |
-#> |.....................|    0.7427 |     1.518 |     1.300 |     1.301 |
-#> |    F| Forward Diff. |     1.422 |    0.2110 |    0.1849 |   -0.1293 |
-#> |.....................|   -0.5889 |   -0.5964 |    0.6731 |     1.405 |
-#> |.....................|   -0.1535 |    0.3114 |    0.2496 |   -0.4521 |
-#> |   65|     458.10133 |    0.9971 |    -1.438 |   -0.9009 |   -0.8698 |
-#> |.....................|   -0.7831 |   -0.5217 |   -0.7321 |   -0.9657 |
-#> |.....................|    -1.026 |   -0.5909 |   -0.6804 |   -0.7139 |
-#> |    U|     458.10133 |     93.73 |    -5.838 |   -0.9798 |   -0.1744 |
-#> |.....................|     2.166 |     2.329 |     1.281 |    0.6862 |
-#> |.....................|    0.7428 |     1.518 |     1.300 |     1.301 |
-#> |    X|     458.10133 |     93.73 |  0.002915 |    0.2729 |    0.8400 |
-#> |.....................|     8.723 |     2.329 |     1.281 |    0.6862 |
-#> |.....................|    0.7428 |     1.518 |     1.300 |     1.301 |
-#> |    F| Forward Diff. |    -2.461 |    0.2094 |    0.1688 |   -0.1332 |
-#> |.....................|   -0.6003 |   -0.7109 |    0.5914 |     1.349 |
-#> |.....................|    -1.404 |    0.2951 |    0.2552 |   -0.4331 |
-#> |   66|     458.10059 |    0.9974 |    -1.438 |   -0.9009 |   -0.8698 |
-#> |.....................|   -0.7830 |   -0.5215 |   -0.7323 |   -0.9660 |
-#> |.....................|    -1.026 |   -0.5909 |   -0.6804 |   -0.7138 |
-#> |    U|     458.10059 |     93.75 |    -5.838 |   -0.9798 |   -0.1744 |
-#> |.....................|     2.166 |     2.330 |     1.281 |    0.6860 |
-#> |.....................|    0.7428 |     1.518 |     1.300 |     1.302 |
-#> |    X|     458.10059 |     93.75 |  0.002915 |    0.2729 |    0.8400 |
-#> |.....................|     8.724 |     2.330 |     1.281 |    0.6860 |
-#> |.....................|    0.7428 |     1.518 |     1.300 |     1.302 |
-#> |    F| Forward Diff. |     1.228 |    0.2101 |    0.1802 |   -0.1294 |
-#> |.....................|   -0.5857 |   -0.2287 |    0.9339 |     1.558 |
-#> |.....................|    -1.376 |    0.3488 |    0.2665 |   -0.4324 |
-#> |   67|     458.10050 |    0.9972 |    -1.438 |   -0.9010 |   -0.8697 |
-#> |.....................|   -0.7829 |   -0.5215 |   -0.7325 |   -0.9663 |
-#> |.....................|    -1.025 |   -0.5910 |   -0.6804 |   -0.7137 |
-#> |    U|      458.1005 |     93.73 |    -5.838 |   -0.9798 |   -0.1744 |
-#> |.....................|     2.166 |     2.330 |     1.281 |    0.6857 |
-#> |.....................|    0.7430 |     1.518 |     1.300 |     1.302 |
-#> |    X|      458.1005 |     93.73 |  0.002915 |    0.2729 |    0.8400 |
-#> |.....................|     8.725 |     2.330 |     1.281 |    0.6857 |
-#> |.....................|    0.7430 |     1.518 |     1.300 |     1.302 |
-#> |    C| Central Diff. |    -2.045 |    0.2058 |    0.1327 |   -0.1461 |
-#> |.....................|   -0.6105 |   -0.6040 |    0.6130 |    0.9518 |
-#> |.....................|   0.01902 |    0.3702 |    0.4676 |   -0.4886 |
-#> |   68|     458.10013 |    0.9974 |    -1.438 |   -0.9010 |   -0.8697 |
-#> |.....................|   -0.7829 |   -0.5214 |   -0.7325 |   -0.9664 |
-#> |.....................|    -1.025 |   -0.5910 |   -0.6805 |   -0.7136 |
-#> |    U|     458.10013 |     93.75 |    -5.838 |   -0.9798 |   -0.1744 |
-#> |.....................|     2.166 |     2.330 |     1.281 |    0.6857 |
-#> |.....................|    0.7430 |     1.518 |     1.300 |     1.302 |
-#> |    X|     458.10013 |     93.75 |  0.002914 |    0.2729 |    0.8400 |
-#> |.....................|     8.725 |     2.330 |     1.281 |    0.6857 |
-#> |.....................|    0.7430 |     1.518 |     1.300 |     1.302 |
-#> |    F| Forward Diff. |    0.8557 |    0.2088 |    0.1747 |   -0.1300 |
-#> |.....................|   -0.5847 |   -0.2393 |    0.9114 |     1.536 |
-#> |.....................|    -1.367 |    0.3016 |    0.2557 |   -0.4123 |
-#> |   69|     458.10002 |    0.9973 |    -1.438 |   -0.9010 |   -0.8697 |
-#> |.....................|   -0.7828 |   -0.5214 |   -0.7326 |   -0.9665 |
-#> |.....................|    -1.025 |   -0.5911 |   -0.6805 |   -0.7136 |
-#> |    U|     458.10002 |     93.74 |    -5.838 |   -0.9798 |   -0.1744 |
-#> |.....................|     2.166 |     2.330 |     1.281 |    0.6856 |
-#> |.....................|    0.7432 |     1.518 |     1.300 |     1.302 |
-#> |    X|     458.10002 |     93.74 |  0.002914 |    0.2729 |    0.8400 |
-#> |.....................|     8.726 |     2.330 |     1.281 |    0.6856 |
-#> |.....................|    0.7432 |     1.518 |     1.300 |     1.302 |
-#> |    C| Central Diff. |   -0.5131 |    0.2058 |    0.1358 |   -0.1441 |
-#> |.....................|   -0.6029 |   -0.6262 |    0.5998 |     1.158 |
-#> |.....................|    -1.373 |    0.3470 |    0.4566 |   -0.4872 |
-#> |   70|     458.09992 |    0.9973 |    -1.438 |   -0.9010 |   -0.8697 |
-#> |.....................|   -0.7827 |   -0.5214 |   -0.7327 |   -0.9666 |
-#> |.....................|    -1.025 |   -0.5911 |   -0.6806 |   -0.7135 |
-#> |    U|     458.09992 |     93.75 |    -5.838 |   -0.9799 |   -0.1743 |
-#> |.....................|     2.166 |     2.330 |     1.281 |    0.6855 |
-#> |.....................|    0.7433 |     1.518 |     1.300 |     1.302 |
-#> |    X|     458.09992 |     93.75 |  0.002914 |    0.2729 |    0.8400 |
-#> |.....................|     8.726 |     2.330 |     1.281 |    0.6855 |
-#> |.....................|    0.7433 |     1.518 |     1.300 |     1.302 |
-#> |    C| Central Diff. |    0.2584 |    0.2056 |    0.1371 |   -0.1438 |
-#> |.....................|   -0.5991 |   -0.6198 |    0.6082 |    0.9676 |
-#> |.....................|     1.295 |    0.3221 |    0.4533 |   -0.4750 |
-#> |   71|     458.09944 |    0.9973 |    -1.438 |   -0.9010 |   -0.8697 |
-#> |.....................|   -0.7827 |   -0.5213 |   -0.7328 |   -0.9668 |
-#> |.....................|    -1.025 |   -0.5911 |   -0.6806 |   -0.7135 |
-#> |    U|     458.09944 |     93.75 |    -5.838 |   -0.9799 |   -0.1743 |
-#> |.....................|     2.166 |     2.330 |     1.281 |    0.6854 |
-#> |.....................|    0.7431 |     1.518 |     1.300 |     1.302 |
-#> |    X|     458.09944 |     93.75 |  0.002914 |    0.2729 |    0.8400 |
-#> |.....................|     8.727 |     2.330 |     1.281 |    0.6854 |
-#> |.....................|    0.7431 |     1.518 |     1.300 |     1.302 |
-#> |   72|     458.09825 |    0.9974 |    -1.438 |   -0.9011 |   -0.8697 |
-#> |.....................|   -0.7824 |   -0.5210 |   -0.7332 |   -0.9672 |
-#> |.....................|    -1.025 |   -0.5911 |   -0.6808 |   -0.7131 |
-#> |    U|     458.09825 |     93.76 |    -5.838 |   -0.9799 |   -0.1743 |
-#> |.....................|     2.167 |     2.330 |     1.280 |    0.6851 |
-#> |.....................|    0.7430 |     1.518 |     1.299 |     1.302 |
-#> |    X|     458.09825 |     93.76 |  0.002914 |    0.2729 |    0.8401 |
-#> |.....................|     8.729 |     2.330 |     1.280 |    0.6851 |
-#> |.....................|    0.7430 |     1.518 |     1.299 |     1.302 |
-#> |   73|     458.09793 |    0.9981 |    -1.438 |   -0.9013 |   -0.8695 |
-#> |.....................|   -0.7815 |   -0.5202 |   -0.7349 |   -0.9686 |
-#> |.....................|    -1.026 |   -0.5909 |   -0.6812 |   -0.7117 |
-#> |    U|     458.09793 |     93.82 |    -5.838 |   -0.9801 |   -0.1741 |
-#> |.....................|     2.168 |     2.331 |     1.279 |    0.6840 |
-#> |.....................|    0.7428 |     1.518 |     1.299 |     1.304 |
-#> |    X|     458.09793 |     93.82 |  0.002913 |    0.2729 |    0.8402 |
-#> |.....................|     8.737 |     2.331 |     1.279 |    0.6840 |
-#> |.....................|    0.7428 |     1.518 |     1.299 |     1.304 |
-#> |    F| Forward Diff. |     10.76 |    0.2116 |    0.1923 |   -0.1162 |
-#> |.....................|   -0.5255 |   -0.5796 |    0.3777 |     1.210 |
-#> |.....................|    -1.409 |    0.2855 |    0.1875 |   -0.3085 |
-#> |   74|     458.08987 |    0.9971 |    -1.438 |   -0.9013 |   -0.8695 |
-#> |.....................|   -0.7808 |   -0.5187 |   -0.7369 |   -0.9692 |
-#> |.....................|    -1.026 |   -0.5907 |   -0.6832 |   -0.7095 |
-#> |    U|     458.08987 |     93.72 |    -5.838 |   -0.9802 |   -0.1741 |
-#> |.....................|     2.168 |     2.332 |     1.278 |    0.6836 |
-#> |.....................|    0.7427 |     1.518 |     1.297 |     1.306 |
-#> |    X|     458.08987 |     93.72 |  0.002914 |    0.2729 |    0.8402 |
-#> |.....................|     8.743 |     2.332 |     1.278 |    0.6836 |
-#> |.....................|    0.7427 |     1.518 |     1.297 |     1.306 |
-#> |    F| Forward Diff. |    -2.512 |    0.2078 |    0.1434 |   -0.1372 |
-#> |.....................|   -0.5667 |   -0.8061 |    0.1467 |     1.033 |
-#> |.....................|     1.202 |   -0.4065 |   0.09417 |   -0.1935 |
-#> |   75|     458.08564 |    0.9973 |    -1.438 |   -0.9016 |   -0.8695 |
-#> |.....................|   -0.7801 |   -0.5170 |   -0.7384 |   -0.9704 |
-#> |.....................|    -1.026 |   -0.5898 |   -0.6859 |   -0.7082 |
-#> |    U|     458.08564 |     93.74 |    -5.838 |   -0.9804 |   -0.1741 |
-#> |.....................|     2.169 |     2.334 |     1.277 |    0.6827 |
-#> |.....................|    0.7424 |     1.519 |     1.294 |     1.308 |
-#> |    X|     458.08564 |     93.74 |  0.002914 |    0.2728 |    0.8402 |
-#> |.....................|     8.749 |     2.334 |     1.277 |    0.6827 |
-#> |.....................|    0.7424 |     1.519 |     1.294 |     1.308 |
-#> |   76|     458.08078 |    0.9972 |    -1.438 |   -0.9021 |   -0.8695 |
-#> |.....................|   -0.7788 |   -0.5136 |   -0.7416 |   -0.9727 |
-#> |.....................|    -1.027 |   -0.5879 |   -0.6916 |   -0.7053 |
-#> |    U|     458.08078 |     93.73 |    -5.838 |   -0.9809 |   -0.1742 |
-#> |.....................|     2.170 |     2.338 |     1.275 |    0.6809 |
-#> |.....................|    0.7420 |     1.522 |     1.288 |     1.311 |
-#> |    X|     458.08078 |     93.73 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.761 |     2.338 |     1.275 |    0.6809 |
-#> |.....................|    0.7420 |     1.522 |     1.288 |     1.311 |
-#> |    F| Forward Diff. |   -0.8456 |    0.2109 |    0.1052 |   -0.1453 |
-#> |.....................|   -0.5381 |   -0.2225 |   -0.1274 |    0.8336 |
-#> |.....................|   -0.2653 |    0.4698 |   -0.4321 |   0.07917 |
-#> |   77|     458.08109 |    0.9983 |    -1.445 |   -0.9066 |   -0.8702 |
-#> |.....................|   -0.7727 |   -0.5143 |   -0.7362 |   -0.9770 |
-#> |.....................|    -1.027 |   -0.5885 |   -0.6915 |   -0.7058 |
-#> |    U|     458.08109 |     93.84 |    -5.845 |   -0.9853 |   -0.1748 |
-#> |.....................|     2.176 |     2.337 |     1.279 |    0.6777 |
-#> |.....................|    0.7418 |     1.521 |     1.288 |     1.310 |
-#> |    X|     458.08109 |     93.84 |  0.002894 |    0.2718 |    0.8396 |
-#> |.....................|     8.815 |     2.337 |     1.279 |    0.6777 |
-#> |.....................|    0.7418 |     1.521 |     1.288 |     1.310 |
-#> |   78|     458.08775 |    0.9985 |    -1.441 |   -0.9040 |   -0.8696 |
-#> |.....................|   -0.7757 |   -0.5136 |   -0.7393 |   -0.9753 |
-#> |.....................|    -1.026 |   -0.5887 |   -0.6911 |   -0.7056 |
-#> |    U|     458.08775 |     93.86 |    -5.841 |   -0.9828 |   -0.1743 |
-#> |.....................|     2.173 |     2.338 |     1.277 |    0.6789 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08775 |     93.86 |  0.002906 |    0.2723 |    0.8401 |
-#> |.....................|     8.788 |     2.338 |     1.277 |    0.6789 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |   79|     458.08407 |    0.9980 |    -1.438 |   -0.9022 |   -0.8694 |
-#> |.....................|   -0.7783 |   -0.5133 |   -0.7415 |   -0.9736 |
-#> |.....................|    -1.026 |   -0.5884 |   -0.6912 |   -0.7054 |
-#> |    U|     458.08407 |     93.81 |    -5.838 |   -0.9810 |   -0.1740 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6802 |
-#> |.....................|    0.7422 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08407 |     93.81 |  0.002915 |    0.2727 |    0.8403 |
-#> |.....................|     8.766 |     2.338 |     1.275 |    0.6802 |
-#> |.....................|    0.7422 |     1.521 |     1.288 |     1.311 |
-#> |   80|     458.08069 |    0.9973 |    -1.438 |   -0.9021 |   -0.8695 |
-#> |.....................|   -0.7787 |   -0.5135 |   -0.7416 |   -0.9729 |
-#> |.....................|    -1.026 |   -0.5880 |   -0.6915 |   -0.7053 |
-#> |    U|     458.08069 |     93.75 |    -5.838 |   -0.9809 |   -0.1741 |
-#> |.....................|     2.170 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7420 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08069 |     93.75 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.762 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7420 |     1.521 |     1.288 |     1.311 |
-#> |    F| Forward Diff. |     1.424 |    0.2112 |    0.1114 |   -0.1426 |
-#> |.....................|   -0.5267 |   -0.3290 |  -0.02249 |    0.9218 |
-#> |.....................|    -1.516 |    0.4273 |   -0.4325 |   0.09748 |
-#> |   81|     458.08076 |    0.9972 |    -1.438 |   -0.9021 |   -0.8695 |
-#> |.....................|   -0.7786 |   -0.5134 |   -0.7416 |   -0.9730 |
-#> |.....................|    -1.026 |   -0.5880 |   -0.6914 |   -0.7055 |
-#> |    U|     458.08076 |     93.74 |    -5.838 |   -0.9810 |   -0.1741 |
-#> |.....................|     2.170 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08076 |     93.74 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.763 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |   82|     458.08078 |    0.9973 |    -1.438 |   -0.9021 |   -0.8695 |
-#> |.....................|   -0.7787 |   -0.5135 |   -0.7416 |   -0.9730 |
-#> |.....................|    -1.026 |   -0.5880 |   -0.6915 |   -0.7053 |
-#> |    U|     458.08078 |     93.74 |    -5.838 |   -0.9809 |   -0.1741 |
-#> |.....................|     2.170 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08078 |     93.74 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.762 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |   83|     458.08068 |    0.9973 |    -1.438 |   -0.9021 |   -0.8695 |
-#> |.....................|   -0.7787 |   -0.5135 |   -0.7416 |   -0.9729 |
-#> |.....................|    -1.026 |   -0.5880 |   -0.6915 |   -0.7053 |
-#> |    U|     458.08068 |     93.75 |    -5.838 |   -0.9809 |   -0.1741 |
-#> |.....................|     2.170 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7420 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08068 |     93.75 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.762 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7420 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |    0.7458 |    0.2086 |   0.07146 |   -0.1568 |
-#> |.....................|   -0.5453 |   -0.1723 |    0.1066 |    0.6006 |
-#> |.....................|  -0.05957 |    0.1717 |   -0.3314 |   0.06442 |
-#> |   84|     458.08065 |    0.9973 |    -1.438 |   -0.9021 |   -0.8695 |
-#> |.....................|   -0.7787 |   -0.5135 |   -0.7416 |   -0.9729 |
-#> |.....................|    -1.026 |   -0.5880 |   -0.6915 |   -0.7053 |
-#> |    U|     458.08065 |     93.74 |    -5.838 |   -0.9809 |   -0.1741 |
-#> |.....................|     2.170 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7420 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08065 |     93.74 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.762 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7420 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |    0.5271 |    0.2085 |   0.07055 |   -0.1570 |
-#> |.....................|   -0.5454 |   -0.3138 |   0.09492 |    0.7765 |
-#> |.....................|     1.192 |    0.4934 |   -0.3382 |    0.1071 |
-#> |   85|     458.08062 |    0.9973 |    -1.438 |   -0.9021 |   -0.8695 |
-#> |.....................|   -0.7786 |   -0.5135 |   -0.7416 |   -0.9730 |
-#> |.....................|    -1.026 |   -0.5880 |   -0.6915 |   -0.7054 |
-#> |    U|     458.08062 |     93.74 |    -5.838 |   -0.9809 |   -0.1741 |
-#> |.....................|     2.170 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7420 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08062 |     93.74 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.762 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7420 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |    0.1077 |    0.2083 |   0.06880 |   -0.1572 |
-#> |.....................|   -0.5469 |   -0.1727 |    0.1219 |    0.9565 |
-#> |.....................|    -1.457 |    0.5128 |   -0.3399 |    0.1022 |
-#> |   86|     458.08061 |    0.9972 |    -1.438 |   -0.9021 |   -0.8695 |
-#> |.....................|   -0.7786 |   -0.5135 |   -0.7416 |   -0.9730 |
-#> |.....................|    -1.026 |   -0.5881 |   -0.6914 |   -0.7054 |
-#> |    U|     458.08061 |     93.74 |    -5.838 |   -0.9809 |   -0.1741 |
-#> |.....................|     2.170 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08061 |     93.74 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.763 |     2.338 |     1.275 |    0.6807 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |   -0.6930 |    0.2078 |   0.06712 |   -0.1577 |
-#> |.....................|   -0.5484 |   -0.1767 |    0.1148 |    0.9863 |
-#> |.....................|   -0.2038 |    0.5855 |   -0.3296 |    0.1002 |
-#> |   87|     458.08058 |    0.9972 |    -1.438 |   -0.9021 |   -0.8695 |
-#> |.....................|   -0.7786 |   -0.5135 |   -0.7416 |   -0.9731 |
-#> |.....................|    -1.026 |   -0.5881 |   -0.6914 |   -0.7054 |
-#> |    U|     458.08058 |     93.74 |    -5.838 |   -0.9809 |   -0.1741 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6806 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08058 |     93.74 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.763 |     2.338 |     1.275 |    0.6806 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |   -0.3701 |    0.2079 |   0.06808 |   -0.1573 |
-#> |.....................|   -0.5470 |   -0.1729 |  0.005725 |    0.9526 |
-#> |.....................|    -1.465 |    0.5101 |   -0.1466 |  -0.02770 |
-#> |   88|     458.08052 |    0.9973 |    -1.438 |   -0.9021 |   -0.8695 |
-#> |.....................|   -0.7785 |   -0.5135 |   -0.7416 |   -0.9731 |
-#> |.....................|    -1.026 |   -0.5881 |   -0.6914 |   -0.7053 |
-#> |    U|     458.08052 |     93.74 |    -5.838 |   -0.9809 |   -0.1741 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6806 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08052 |     93.74 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.763 |     2.338 |     1.275 |    0.6806 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |    0.2062 |    0.2080 |   0.06837 |   -0.1566 |
-#> |.....................|   -0.5439 |   -0.1704 |   0.09858 |    0.5928 |
-#> |.....................|  -0.05984 |    0.5131 |   -0.3447 |   0.06046 |
-#> |   89|     458.08047 |    0.9972 |    -1.438 |   -0.9021 |   -0.8694 |
-#> |.....................|   -0.7785 |   -0.5134 |   -0.7416 |   -0.9732 |
-#> |.....................|    -1.026 |   -0.5882 |   -0.6914 |   -0.7054 |
-#> |    U|     458.08047 |     93.74 |    -5.838 |   -0.9809 |   -0.1741 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6805 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08047 |     93.74 |  0.002915 |    0.2727 |    0.8402 |
-#> |.....................|     8.764 |     2.338 |     1.275 |    0.6805 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |  -0.06148 |    0.2077 |   0.06828 |   -0.1566 |
-#> |.....................|   -0.5434 |   -0.1748 |    0.1045 |    0.7316 |
-#> |.....................|   -0.7607 |    0.4924 |   -0.3350 |    0.1046 |
-#> |   90|     458.08041 |    0.9972 |    -1.438 |   -0.9021 |   -0.8694 |
-#> |.....................|   -0.7784 |   -0.5134 |   -0.7417 |   -0.9733 |
-#> |.....................|    -1.026 |   -0.5883 |   -0.6913 |   -0.7054 |
-#> |    U|     458.08041 |     93.74 |    -5.838 |   -0.9810 |   -0.1740 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6804 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08041 |     93.74 |  0.002915 |    0.2727 |    0.8403 |
-#> |.....................|     8.765 |     2.338 |     1.275 |    0.6804 |
-#> |.....................|    0.7421 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |   -0.5076 |    0.2073 |   0.06528 |   -0.1564 |
-#> |.....................|   -0.5454 |   -0.1802 |    0.1061 |    0.9740 |
-#> |.....................|   -0.1992 |    0.5430 |   -0.2714 |    0.1031 |
-#> |   91|     458.08026 |    0.9972 |    -1.438 |   -0.9022 |   -0.8694 |
-#> |.....................|   -0.7782 |   -0.5133 |   -0.7417 |   -0.9736 |
-#> |.....................|    -1.026 |   -0.5884 |   -0.6912 |   -0.7055 |
-#> |    U|     458.08026 |     93.74 |    -5.838 |   -0.9810 |   -0.1740 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6802 |
-#> |.....................|    0.7422 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08026 |     93.74 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.766 |     2.338 |     1.275 |    0.6802 |
-#> |.....................|    0.7422 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |   -0.3779 |    0.2092 |   0.07455 |   -0.1547 |
-#> |.....................|   -0.5349 |    0.4172 |   -0.5362 |    0.7903 |
-#> |.....................|    -1.451 |    0.5182 |   -0.2163 |   -0.4361 |
-#> |   92|     458.08039 |    0.9975 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7778 |   -0.5133 |   -0.7416 |   -0.9742 |
-#> |.....................|    -1.026 |   -0.5887 |   -0.6910 |   -0.7056 |
-#> |    U|     458.08039 |     93.76 |    -5.838 |   -0.9811 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6798 |
-#> |.....................|    0.7424 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08039 |     93.76 |  0.002914 |    0.2727 |    0.8404 |
-#> |.....................|     8.769 |     2.338 |     1.275 |    0.6798 |
-#> |.....................|    0.7424 |     1.521 |     1.288 |     1.311 |
-#> |   93|     458.08025 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08025 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08025 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |     1.019 |    0.2066 |   0.06601 |   -0.1530 |
-#> |.....................|   -0.5270 |   -0.1637 |    0.1163 |    0.9184 |
-#> |.....................|    -1.439 |    0.4715 |   -0.2217 |   0.03756 |
-#> |   94|     458.08029 |    0.9972 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08029 |     93.74 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7424 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08029 |     93.74 |  0.002914 |    0.2727 |    0.8404 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7424 |     1.521 |     1.288 |     1.311 |
-#> |   95|     458.08025 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08025 |     93.74 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7424 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08025 |     93.74 |  0.002914 |    0.2727 |    0.8404 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7424 |     1.521 |     1.288 |     1.311 |
-#> |   96|     458.08029 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08029 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08029 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |   97|     458.08024 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08024 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08024 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |    0.9275 |    0.2065 |   0.06562 |   -0.1530 |
-#> |.....................|   -0.5278 |   -0.1682 |    0.1168 |    0.9523 |
-#> |.....................|   -0.1838 |    0.4888 |   -0.3154 |   0.09539 |
-#> |   98|     458.08024 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08024 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08024 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |    0.8715 |    0.2065 |   0.06540 |   -0.1531 |
-#> |.....................|   -0.5308 |  -0.07756 |    0.1164 |    0.5595 |
-#> |.....................|  -0.04465 |   -0.2577 |   -0.3240 |    0.1066 |
-#> |   99|     458.08023 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08023 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08023 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  100|     458.08013 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08013 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08013 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    C| Central Diff. |    0.7255 |    0.2064 |   0.06482 |   -0.1531 |
-#> |.....................|   -0.5283 |   -0.1617 |    0.1081 |    0.9192 |
-#> |.....................|    -1.441 |    0.4906 |   -0.2900 |    0.1161 |
-#> |  101|     458.08017 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5885 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08017 |     93.74 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08017 |     93.74 |  0.002914 |    0.2727 |    0.8404 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  102|     458.08021 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08021 |     93.74 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08021 |     93.74 |  0.002914 |    0.2727 |    0.8404 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  103|     458.08029 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08029 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08029 |     93.75 |  0.002914 |    0.2727 |    0.8404 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  104|     458.08032 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08032 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08032 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  105|     458.08033 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08033 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08033 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  106|     458.08032 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08032 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08032 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  107|     458.08032 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08032 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08032 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  108|     458.08032 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08032 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08032 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  109|     458.08032 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08032 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08032 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  110|     458.08032 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08032 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08032 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  111|     458.08032 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08032 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08032 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |  112|     458.08032 |    0.9973 |    -1.438 |   -0.9022 |   -0.8693 |
-#> |.....................|   -0.7780 |   -0.5133 |   -0.7416 |   -0.9739 |
-#> |.....................|    -1.026 |   -0.5886 |   -0.6911 |   -0.7055 |
-#> |    U|     458.08032 |     93.75 |    -5.838 |   -0.9810 |   -0.1739 |
-#> |.....................|     2.171 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> |    X|     458.08032 |     93.75 |  0.002914 |    0.2727 |    0.8403 |
-#> |.....................|     8.768 |     2.338 |     1.275 |    0.6800 |
-#> |.....................|    0.7423 |     1.521 |     1.288 |     1.311 |
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-f_nlmixr_dfop_sfo_saem_obs <- nlmixr(f_mmkin_obs["DFOP-SFO", ], est = "saem")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#>  
-#> → generate SAEM model
-#> ✔ done
-#> 1:    93.0952   -5.6337   -1.8988   -4.1294   -1.2035    0.1038    5.2152    1.6150    1.0450    2.6377    0.5035    0.5225   20.0768   11.4566
-#> 2:    93.1464   -5.6948   -1.8729   -4.2029   -1.1302    0.1295    5.5478    1.5342    0.9927    2.5059    0.4783    0.5147   11.2089    8.1577
-#> 3:    93.1719   -5.7029   -1.8810   -4.2024   -1.0686    0.1063    5.2764    1.5217    0.9431    2.3806    0.4544    0.5587    9.3753    5.7166
-#> 4:    92.8647   -5.8139   -1.8979   -4.1992   -1.0168    0.1122    5.4892    1.7893    0.8960    2.2615    0.4317    0.5307    9.4134    4.7166
-#> 5:    92.7759   -5.8627   -1.8873   -4.1402   -1.0347    0.1243    6.2028    2.1819    0.8795    2.1485    0.4101    0.5042    9.5964    4.7340
-#> 6:    92.8080   -5.8954   -1.9186   -4.1772   -0.9727    0.1311    5.8926    2.0728    0.8633    2.0410    0.3896    0.4790    8.7334    4.1957
-#> 7:    92.9042   -5.9034   -1.9603   -4.1854   -0.9717    0.1630    5.5980    2.2068    0.8672    1.9390    0.3701    0.4550    8.7213    3.3409
-#> 8:    92.9302   -5.8545   -1.9240   -4.2343   -0.9748    0.1686    5.3181    2.3934    0.8239    1.9533    0.3516    0.4323    7.6950    2.9174
-#> 9:    92.9518   -5.5561   -1.9734   -4.1856   -0.9322    0.2129    5.0522    2.2738    0.7830    2.0138    0.3340    0.4689    7.9230    2.1930
-#> 10:    93.0672   -5.5564   -1.9633   -4.1456   -0.9343    0.2049    4.7996    2.1601    0.7438    2.0517    0.3173    0.4771    8.0644    2.0682
-#> 11:    92.6849   -5.6187   -1.9773   -4.1793   -0.9342    0.2290    4.5596    2.0521    0.7123    2.0774    0.3015    0.5052    8.2355    1.9349
-#> 12:    92.6425   -5.6989   -2.0144   -4.1395   -0.9342    0.2669    4.3316    2.2634    0.7142    2.3008    0.2864    0.5728    7.5188    1.8028
-#> 13:    92.2996   -5.6700   -1.9885   -4.0443   -0.9202    0.2750    4.5787    2.1608    0.7019    2.7515    0.2721    0.6641    7.0744    1.8958
-#> 14:    92.2457   -5.5825   -2.0314   -3.9788   -0.9142    0.2908    6.3744    2.0527    0.7018    3.2703    0.2585    0.6387    6.9499    1.8421
-#> 15:    92.1741   -5.5333   -2.0318   -3.9664   -0.9059    0.2894    6.0557    1.9501    0.7179    3.2869    0.2455    0.6068    7.0951    1.6824
-#> 16:    92.5772   -5.4982   -2.0352   -3.9471   -0.9063    0.2930    5.7529    1.8526    0.7244    3.6994    0.2333    0.5764    7.2138    1.7042
-#> 17:    92.7024   -5.4902   -2.0438   -4.0347   -0.9079    0.2959    5.4652    1.7600    0.7393    3.5144    0.2216    0.5765    7.0258    1.6793
-#> 18:    92.0240   -5.5539   -2.0520   -3.9601   -0.9079    0.2884    6.5142    1.9232    0.7320    3.9052    0.2157    0.5521    7.2568    1.6151
-#> 19:    92.6532   -5.6325   -2.0456   -3.9091   -0.9179    0.3047    6.5743    2.3363    0.7405    4.5825    0.2049    0.5425    7.6201    1.6565
-#> 20:    92.3488   -5.6617   -2.0554   -3.9501   -0.9216    0.3056    6.7080    2.7562    0.7218    4.7569    0.2083    0.5432    7.3481    1.8059
-#> 21:    92.5679   -5.7469   -2.0614   -4.0829   -0.8890    0.3158    6.6510    3.1993    0.7136    4.5191    0.1978    0.5281    7.3723    1.7461
-#> 22:    92.4785   -5.9527   -2.0657   -4.0580   -0.8971    0.3084    6.3184    4.1791    0.7144    4.2931    0.1929    0.5157    7.1922    1.6984
-#> 23:    92.5594   -5.8590   -2.0723   -4.0580   -0.9020    0.2952    6.0025    3.9702    0.7335    4.0784    0.1833    0.5129    7.7560    1.6302
-#> 24:    92.6152   -5.9488   -2.0658   -4.1187   -0.9050    0.2997    5.7024    4.5381    0.7215    3.8745    0.1875    0.5129    7.6182    1.6362
-#> 25:    92.4658   -5.8715   -2.0791   -4.0949   -0.8922    0.3074    6.1428    4.3112    0.7353    3.6808    0.1896    0.5157    7.2703    1.5633
-#> 26:    92.2507   -5.9797   -2.0707   -4.0834   -0.8868    0.3266    6.4124    4.7125    0.7334    3.5368    0.1851    0.5217    7.3085    1.5828
-#> 27:    92.7055   -5.9792   -2.0779   -4.2066   -0.8887    0.2993    6.0918    4.8624    0.7659    3.7456    0.1841    0.4956    7.3534    1.5240
-#> 28:    92.3971   -6.0253   -2.0648   -4.1406   -0.9042    0.2897    5.7872    4.7690    0.7449    3.5583    0.1823    0.4709    7.2479    1.5008
-#> 29:    92.4045   -5.9045   -2.0730   -4.1407   -0.8969    0.3103    5.6683    4.5306    0.7349    3.3816    0.1849    0.5054    7.1719    1.6004
-#> 30:    92.1714   -5.8598   -2.0645   -4.0913   -0.8964    0.2743    5.3849    4.3040    0.7538    3.3509    0.1757    0.4801    7.3739    1.5736
-#> 31:    91.9134   -5.7867   -2.0367   -4.0563   -0.8957    0.2280    5.1156    4.0888    0.7299    3.3452    0.1749    0.4673    6.5991    1.5909
-#> 32:    92.3743   -5.9967   -2.0255   -4.0668   -0.9025    0.2247    4.8599    4.6666    0.7256    3.3271    0.1714    0.5008    6.4693    1.5458
-#> 33:    92.5239   -5.9301   -2.0387   -4.0365   -0.9033    0.2558    4.6169    4.4333    0.7492    3.6109    0.1688    0.5424    6.7730    1.5771
-#> 34:    92.6892   -6.1135   -2.0587   -4.0280   -0.8993    0.2430    4.3860    6.0227    0.7798    3.5725    0.1672    0.5153    6.8110    1.5417
-#> 35:    92.7276   -6.0815   -2.0629   -4.0833   -0.8943    0.2375    4.6811    5.7216    0.8010    3.3939    0.1715    0.4895    6.6812    1.5478
-#> 36:    92.7316   -6.0691   -2.0882   -4.0626   -0.9030    0.2405    4.4614    5.4355    0.8355    3.2242    0.1789    0.4650    6.8443    1.4806
-#> 37:    92.6685   -5.7905   -2.0666   -4.0663   -0.8998    0.2784    5.1916    5.1637    0.7937    3.0641    0.1823    0.4418    6.5421    1.6284
-#> 38:    93.0325   -5.6829   -2.0674   -4.0772   -0.9167    0.2499    4.9320    4.9055    0.7768    3.1213    0.1887    0.4290    6.8220    1.5224
-#> 39:    93.0378   -5.5554   -2.0743   -4.0772   -0.9189    0.2361    4.6854    4.6603    0.7822    3.1213    0.1813    0.4242    7.1137    1.5021
-#> 40:    93.3297   -5.6270   -2.0591   -4.1200   -0.9167    0.2035    4.4511    4.4272    0.8128    2.9653    0.1829    0.4030    7.3894    1.5064
-#> 41:    93.3408   -5.5437   -2.0344   -4.1042   -0.9078    0.1744    4.2286    4.2059    0.8228    2.8170    0.1881    0.3829    7.2734    1.5519
-#> 42:    93.1691   -5.4436   -2.0551   -4.1048   -0.8984    0.1732    4.0172    3.9956    0.7816    2.6762    0.1853    0.3637    6.9712    1.5332
-#> 43:    93.2443   -5.5247   -2.0722   -4.0980   -0.8992    0.1756    3.8163    3.7958    0.7781    2.7200    0.1956    0.3455    6.7012    1.5344
-#> 44:    92.9509   -5.5020   -2.0495   -4.0961   -0.8964    0.1777    3.6255    3.6060    0.7555    2.8172    0.1994    0.3283    6.2180    1.6137
-#> 45:    92.8898   -5.4913   -2.0462   -4.1079   -0.9003    0.1701    4.1177    3.4257    0.7491    2.8491    0.1989    0.3372    6.2876    1.6205
-#> 46:    92.6044   -5.6429   -2.0499   -4.1079   -0.9069    0.1999    4.2103    3.2544    0.7657    2.8491    0.1921    0.3532    6.2261    1.6435
-#> 47:    92.7740   -5.6128   -2.0804   -4.1186   -0.8976    0.1864    5.2188    3.0917    0.7381    2.9036    0.2030    0.3391    6.6803    1.6177
-#> 48:    92.4691   -5.6645   -2.0600   -4.1288   -0.8796    0.1913    6.2045    2.9371    0.7774    2.9223    0.1966    0.3396    6.7169    1.6215
-#> 49:    92.4128   -5.7079   -2.0802   -4.1166   -0.8798    0.1741    5.8943    3.1446    0.7854    2.8715    0.1935    0.3369    6.9151    1.4834
-#> 50:    91.8883   -5.7713   -2.0932   -4.0899   -0.8886    0.1758    5.5996    3.5478    0.8033    2.8192    0.2014    0.3201    7.0775    1.4635
-#> 51:    92.1187   -5.7306   -2.0903   -4.0878   -0.8923    0.2024    5.3196    3.6534    0.7823    2.7891    0.1969    0.3140    6.9879    1.5430
-#> 52:    92.3209   -5.7897   -2.0903   -4.1622   -0.9072    0.2261    5.3781    3.4707    0.8001    3.0801    0.2063    0.3088    6.7047    1.4499
-#> 53:    92.4318   -5.6954   -2.0950   -4.1866   -0.9082    0.2131    7.1200    3.2972    0.7711    3.3398    0.2034    0.3186    6.6152    1.5123
-#> 54:    92.5380   -5.6975   -2.0782   -4.2394   -0.8976    0.2118    6.7640    3.1323    0.7744    3.5385    0.2175    0.3296    6.4402    1.5403
-#> 55:    92.7213   -5.6663   -2.0427   -4.3288   -0.9028    0.2032    8.1796    2.9757    0.7748    4.4495    0.2142    0.3316    6.4111    1.5369
-#> 56:    92.7219   -5.6865   -2.0557   -4.3434   -0.9084    0.2021    7.7706    2.8269    0.7989    4.6691    0.2174    0.3433    6.4256    1.4639
-#> 57:    92.8932   -5.5736   -2.0497   -4.3955   -0.9216    0.1694    7.3821    2.6856    0.8205    4.9791    0.2142    0.3500    6.5378    1.5406
-#> 58:    92.9219   -5.5789   -2.0547   -4.3094   -0.9183    0.1838    7.0130    2.5513    0.7958    4.7302    0.2193    0.3495    6.2662    1.4940
-#> 59:    93.0432   -5.6201   -2.0395   -4.2527   -0.9199    0.2302    6.6623    2.4237    0.8241    4.4937    0.2241    0.3321    5.8693    1.6176
-#> 60:    92.9724   -5.5971   -2.0537   -4.3509   -0.9219    0.2118    7.5905    2.3026    0.8418    4.4546    0.2177    0.3155    5.5960    1.5040
-#> 61:    93.1235   -5.6332   -2.0671   -4.3572   -0.9219    0.1917    7.2521    2.3037    0.8527    4.5707    0.2230    0.2997    5.8136    1.4516
-#> 62:    93.5431   -5.6373   -2.0371   -4.3384   -0.9276    0.1997    8.5187    2.3895    0.8575    4.4378    0.2258    0.3041    5.5746    1.4572
-#> 63:    93.5009   -5.5634   -2.0224   -4.3560   -0.9339    0.2167    8.0927    2.2700    0.8462    4.4449    0.2266    0.3162    5.4922    1.5233
-#> 64:    93.7369   -5.6032   -2.0362   -4.2323   -0.9355    0.2159    9.6684    2.1949    0.8514    4.2227    0.2300    0.3318    5.7597    1.4866
-#> 65:    93.5021   -5.5769   -2.0311   -4.3204   -0.9375    0.1927    9.5537    2.0852    0.8559    4.6151    0.2208    0.3550    5.6975    1.5031
-#> 66:    93.4211   -5.7184   -2.0384   -4.3041   -0.9228    0.2121    9.0760    2.6390    0.8430    4.3843    0.2098    0.3755    5.8990    1.5133
-#> 67:    93.3435   -5.6579   -2.0456   -4.2222   -0.9183    0.1825    8.6222    2.5071    0.8719    4.1651    0.2152    0.3567    5.9004    1.4874
-#> 68:    93.3914   -5.6554   -2.0420   -4.1618   -0.9303    0.1714    8.1911    2.3817    0.8856    3.9569    0.2272    0.3388    6.1793    1.4917
-#> 69:    93.5112   -5.6834   -2.0349   -4.1591   -0.9331    0.1759    8.9900    2.5191    0.9184    3.7590    0.2236    0.3219    6.1618    1.4697
-#> 70:    93.4289   -5.6576   -2.0273   -4.1763   -0.9399    0.1738    8.5405    2.4302    0.8725    3.5711    0.2149    0.3288    6.5324    1.5410
-#> 71:    93.2936   -5.6699   -2.0256   -4.1405   -0.9370    0.1922    8.1134    2.3831    0.8289    3.3925    0.2080    0.3548    5.9794    1.5904
-#> 72:    92.9152   -5.6742   -2.0382   -4.1523   -0.9411    0.1991    7.7078    2.4322    0.7875    3.2916    0.2007    0.3456    6.0999    1.6022
-#> 73:    92.8129   -5.8099   -2.0372   -4.1735   -0.9377    0.1605    8.2752    2.8931    0.7737    3.4015    0.2057    0.3283    6.0140    1.5472
-#> 74:    92.7806   -5.7269   -2.0315   -4.1877   -0.9399    0.1675    8.4688    2.7484    0.7773    3.4620    0.2174    0.3249    5.8495    1.5779
-#> 75:    92.9128   -5.8680   -2.0304   -4.1459   -0.9387    0.1567    8.0454    3.2365    0.7681    3.2935    0.2198    0.3187    5.8539    1.5815
-#> 76:    92.8931   -5.8483   -2.0253   -4.1815   -0.9387    0.1540    9.6800    3.0747    0.8007    3.5838    0.2198    0.3291    5.9005    1.5053
-#> 77:    92.7474   -5.7995   -2.0202   -4.1904   -0.9333    0.1724   10.0488    2.9210    0.7841    3.7255    0.2148    0.3465    5.9418    1.5569
-#> 78:    92.8150   -5.9608   -2.0025   -4.1583   -0.9511    0.1566    9.5464    3.5249    0.7858    3.6988    0.2246    0.3292    5.7737    1.5904
-#> 79:    92.6663   -6.0485   -2.0245   -4.1437   -0.9446    0.1786    9.0690    4.1252    0.7803    3.6526    0.2155    0.3335    5.9109    1.5521
-#> 80:    92.5932   -6.1001   -2.0304   -4.1969   -0.9409    0.1424    8.6156    4.6478    0.8007    4.0379    0.2114    0.3168    6.1732    1.5544
-#> 81:    92.6789   -6.3510   -2.0062   -4.2272   -0.9541    0.1360    8.3363    5.9861    0.7719    3.8800    0.2202    0.3010    5.6841    1.6317
-#> 82:    92.9996   -6.5680   -2.0048   -4.1609   -0.9578    0.1367   10.6901    7.4391    0.7962    3.6860    0.2092    0.2859    5.7335    1.6391
-#> 83:    93.1087   -6.5298   -1.9757   -4.1694   -0.9596    0.1323   10.5524    7.4660    0.8237    3.8009    0.2134    0.2716    5.9664    1.6316
-#> 84:    93.1929   -6.5844   -2.0191   -4.2021   -0.9616    0.1384   10.0248    7.7313    0.8230    3.6109    0.2110    0.2580    5.7854    1.5609
-#> 85:    92.9161   -6.4934   -2.0281   -4.2008   -0.9600    0.1107    9.5236    7.4269    0.8448    3.5630    0.2110    0.2451    5.6111    1.5333
-#> 86:    92.9816   -6.5397   -2.0234   -4.1830   -0.9694    0.1111    9.1945    7.4382    0.8481    3.3849    0.2166    0.2329    5.8375    1.5263
-#> 87:    93.0930   -6.5749   -2.0168   -4.1986   -0.9816    0.0926    8.7348    8.4431    0.8646    3.3032    0.2155    0.2212    5.7542    1.5736
-#> 88:    93.0765   -6.4914   -2.0274   -4.2274   -0.9870    0.1148    8.4666    8.0209    0.8666    3.5292    0.2048    0.2102    5.8988    1.5329
-#> 89:    92.8699   -6.6431   -2.0199   -4.2175   -0.9463    0.1011    8.4648    7.7973    0.8908    3.3980    0.1945    0.2102    5.6876    1.5177
-#> 90:    92.8225   -6.6932   -2.0211   -4.2175   -0.9505    0.0887   10.1862    8.7787    0.8730    3.3980    0.1877    0.1997    5.9135    1.4821
-#> 91:    92.7874   -6.7007   -2.0420   -4.2936   -0.9468    0.0927   11.2275    8.3397    0.8600    3.9490    0.1885    0.2147    6.1108    1.4315
-#> 92:    93.2320   -6.8088   -2.0341   -4.2817   -0.9582    0.1270   12.4029    9.6204    0.8503    3.7516    0.1950    0.2070    5.9434    1.5251
-#> 93:    93.8996   -6.5471   -2.0440   -4.2123   -0.9543    0.1140   11.7828    9.1394    0.8493    3.5640    0.1988    0.2017    6.1302    1.5568
-#> 94:    93.4416   -6.4623   -2.0448   -4.2188   -0.9595    0.1174   12.1277    8.6824    0.8568    3.3858    0.1975    0.1938    5.9173    1.5204
-#> 95:    93.2953   -6.1521   -2.0477   -4.2216   -0.9551    0.1152   11.5213    8.2483    0.8356    3.2165    0.1979    0.1855    5.8298    1.5357
-#> 96:    92.9577   -6.0477   -2.0579   -4.2534   -0.9465    0.1284   10.9452    7.8359    0.8202    3.3357    0.1937    0.1917    5.8590    1.5738
-#> 97:    92.8703   -6.1037   -2.0745   -4.1960   -0.9405    0.1417   10.4858    7.4441    0.8488    3.1690    0.1969    0.2016    5.7948    1.4759
-#> 98:    92.9728   -6.3534   -2.0868   -4.2155   -0.9444    0.1069    9.9615    7.1788    0.8736    3.1913    0.1998    0.2114    5.6533    1.4322
-#> 99:    93.4116   -6.1712   -2.0837   -4.2280   -0.9473    0.1197    9.4634    6.8198    0.8959    3.1806    0.1899    0.2167    5.9149    1.3768
-#> 100:    93.2598   -6.1345   -2.0645   -4.2237   -0.9575    0.1099    8.9903    6.4788    0.9204    3.2429    0.1903    0.2058    5.7085    1.4133
-#> 101:    93.3082   -6.1574   -2.0474   -4.2315   -0.9619    0.1161    9.0819    6.1549    0.8744    3.2049    0.1891    0.2278    5.6493    1.4894
-#> 102:    93.5741   -6.2923   -2.0484   -4.2853   -0.9665    0.1325   10.4108    5.8522    0.8804    3.5370    0.2024    0.2324    5.6995    1.4594
-#> 103:    92.9199   -6.1797   -2.0522   -4.2940   -0.9568    0.1289    9.8903    5.5596    0.8722    3.6682    0.1975    0.2398    5.5536    1.4510
-#> 104:    93.1139   -6.1630   -2.0546   -4.2912   -0.9613    0.1115    9.3958    5.2816    0.8648    3.6673    0.2010    0.2278    5.5768    1.4812
-#> 105:    93.4085   -6.0359   -2.0450   -4.2889   -0.9591    0.1258    8.9260    5.0175    0.8412    3.7286    0.1917    0.2171    5.6780    1.5203
-#> 106:    93.3103   -6.1029   -2.0425   -4.2948   -0.9579    0.0934    8.4797    4.7667    0.8539    3.6947    0.1947    0.2234    5.7210    1.4760
-#> 107:    93.6389   -5.9750   -2.0309   -4.2630   -0.9660    0.1110    8.0557    4.5283    0.8470    3.5100    0.2044    0.2299    5.6280    1.5525
-#> 108:    93.8641   -5.8551   -2.0360   -4.2311   -0.9629    0.0900    7.6529    4.3019    0.8567    3.3345    0.2014    0.2302    5.7841    1.5978
-#> 109:    93.6274   -6.0268   -2.0445   -4.3047   -0.9488    0.0979    7.2703    4.7807    0.8565    3.7665    0.1929    0.2271    5.7941    1.5580
-#> 110:    93.6320   -5.8321   -2.0413   -4.2855   -0.9477    0.1143    6.9068    4.5417    0.8412    3.6165    0.1901    0.2199    5.8169    1.5477
-#> 111:    93.6245   -5.8256   -2.0157   -4.2797   -0.9612    0.0940    6.5774    4.3146    0.8460    3.5782    0.1837    0.2182    5.6157    1.6424
-#> 112:    93.8512   -5.9045   -2.0116   -4.2409   -0.9708    0.0883    6.2486    4.0989    0.8658    3.5059    0.1761    0.2073    5.8852    1.6073
-#> 113:    93.7080   -5.9935   -2.0306   -4.1884   -0.9690    0.0740    5.9361    4.0088    0.9072    3.3400    0.1957    0.2169    6.3792    1.4770
-#> 114:    93.8574   -5.9185   -2.0233   -4.2030   -0.9588    0.1137    5.6393    3.8084    0.9322    3.2878    0.1939    0.2098    5.8891    1.5325
-#> 115:    93.7414   -5.8789   -2.0183   -4.2256   -0.9701    0.1105    5.6148    3.6180    0.9222    3.5507    0.1921    0.1993    5.6441    1.5458
-#> 116:    93.4104   -5.9704   -2.0428   -4.2091   -0.9807    0.1099    5.3341    4.1157    0.9363    3.4004    0.1968    0.2134    5.7764    1.4617
-#> 117:    93.5239   -5.9057   -2.0518   -4.2494   -0.9812    0.1127    6.8839    3.9099    0.9151    3.6604    0.1921    0.2095    5.4753    1.4249
-#> 118:    93.7599   -5.9418   -2.0482   -4.2272   -0.9822    0.1094    6.8133    3.7144    0.9198    3.5160    0.1971    0.2039    5.6467    1.4116
-#> 119:    93.6617   -6.0020   -2.0483   -4.2146   -0.9816    0.1003    6.4727    3.8251    0.9103    3.4716    0.1950    0.2109    5.8513    1.4268
-#> 120:    93.5436   -5.9804   -2.0458   -4.1906   -0.9819    0.1065    6.1490    3.6756    0.9088    3.2980    0.1989    0.2123    5.8268    1.4689
-#> 121:    93.4880   -5.9047   -2.0452   -4.1957   -0.9640    0.1349    5.8416    3.4918    0.8824    3.2437    0.1889    0.2017    5.7152    1.4382
-#> 122:    93.7406   -5.9844   -2.0596   -4.2328   -0.9558    0.1563    5.5495    3.7606    0.8489    3.3043    0.1795    0.2015    5.5095    1.5112
-#> 123:    93.6728   -6.0394   -2.0372   -4.2812   -0.9592    0.1507    5.2720    4.2004    0.8341    3.5274    0.1817    0.2008    5.6936    1.6011
-#> 124:    93.9591   -6.0483   -2.0280   -4.2613   -0.9594    0.1463    5.3846    4.1913    0.8351    3.4341    0.1870    0.2193    5.5694    1.5684
-#> 125:    94.0201   -5.9102   -2.0507   -4.2686   -0.9697    0.1455    5.1154    3.9818    0.8512    3.3475    0.1859    0.2165    5.6224    1.5643
-#> 126:    93.8825   -5.8970   -2.0543   -4.2569   -0.9663    0.1493    4.9144    3.7827    0.8907    3.3030    0.1876    0.2180    5.7351    1.4722
-#> 127:    93.9893   -5.8955   -2.0624   -4.2430   -0.9802    0.1476    7.2413    3.5935    0.8915    3.2740    0.1851    0.2110    5.7614    1.4305
-#> 128:    94.1849   -5.9123   -2.0624   -4.2385   -0.9786    0.1523    7.9575    3.4139    0.9094    3.2656    0.1807    0.2198    5.7366    1.4264
-#> 129:    94.0812   -6.0044   -2.0696   -4.3056   -0.9770    0.1693    8.7809    3.7526    0.9111    3.6172    0.1859    0.2255    5.8064    1.4718
-#> 130:    93.6046   -6.1387   -2.0718   -4.3056   -0.9821    0.1477    8.3419    4.3029    0.9177    3.6172    0.1867    0.2143    5.8893    1.4447
-#> 131:    93.5216   -6.1347   -2.0740   -4.3114   -0.9766    0.1288    8.2937    4.3407    0.9250    3.5298    0.1881    0.2293    5.8054    1.4219
-#> 132:    93.6142   -6.2789   -2.0786   -4.3297   -0.9716    0.1288    8.3731    5.1225    0.9236    3.6683    0.1929    0.2295    5.8064    1.4194
-#> 133:    93.4410   -5.9177   -2.0916   -4.3557   -0.9798    0.1066    7.9544    4.8663    0.9537    3.7076    0.1937    0.2279    5.9844    1.4297
-#> 134:    93.4716   -5.9152   -2.0838   -4.3611   -0.9818    0.1332    7.5567    4.6230    0.9161    3.7833    0.2017    0.2308    6.0611    1.5717
-#> 135:    93.3787   -6.0381   -2.0728   -4.2627   -0.9719    0.1051    7.2396    4.3919    0.8970    3.5941    0.1916    0.2193    5.8837    1.6057
-#> 136:    93.4339   -5.9876   -2.0801   -4.3002   -0.9690    0.1214    6.8776    4.1723    0.8888    3.4144    0.2002    0.2227    6.0141    1.5231
-#> 137:    93.7639   -6.0411   -2.0803   -4.2799   -0.9646    0.1484    6.5337    3.9765    0.8969    3.2437    0.1995    0.2115    5.9404    1.6402
-#> 138:    93.6414   -6.0122   -2.0714   -4.2666   -0.9755    0.1506    7.4057    3.7962    0.9242    3.1524    0.1934    0.2010    6.0666    1.5001
-#> 139:    93.7743   -5.7966   -2.0613   -4.2289   -0.9722    0.1383    7.9358    3.6064    0.9015    2.9948    0.1946    0.2029    5.9655    1.5250
-#> 140:    93.1082   -5.7994   -2.0388   -4.2289   -0.9659    0.1382    8.0282    3.4261    0.9053    2.9079    0.1909    0.2138    5.9183    1.5191
-#> 141:    93.2122   -6.0181   -2.0396   -4.2398   -0.9587    0.1016    8.9769    3.9426    0.9028    2.9136    0.1941    0.2195    6.1560    1.4902
-#> 142:    93.4684   -6.1438   -2.0273   -4.2541   -0.9508    0.0848    8.5281    4.8727    0.9056    2.9875    0.1901    0.2233    6.2546    1.4695
-#> 143:    93.0059   -6.0964   -2.0145   -4.2760   -0.9563    0.0826    8.1017    4.6291    0.9312    3.1063    0.1850    0.2138    6.5768    1.4391
-#> 144:    93.0612   -6.1127   -1.9951   -4.2589   -0.9539    0.0904    7.6966    4.6160    0.9623    3.1681    0.1824    0.2032    6.1506    1.4497
-#> 145:    93.5170   -6.1066   -1.9951   -4.3574   -0.9478    0.1040    7.3118    4.6263    0.9639    3.6914    0.1986    0.2292    5.9389    1.4867
-#> 146:    93.4915   -6.3235   -2.0006   -4.3866   -0.9579    0.1202    6.9462    6.0529    0.9514    3.9899    0.1887    0.2335    5.9265    1.4978
-#> 147:    93.8963   -6.1119   -2.0055   -4.3446   -0.9682    0.1242    7.1711    5.7503    0.9315    3.7904    0.1923    0.2332    5.9346    1.5021
-#> 148:    93.6758   -5.9705   -2.0137   -4.2906   -0.9614    0.1125    6.8125    5.4628    0.9506    3.6009    0.1913    0.2371    6.2579    1.4384
-#> 149:    93.6499   -6.0049   -2.0246   -4.2730   -0.9776    0.0996    6.4719    5.1896    0.9736    3.4209    0.1817    0.2252    6.3224    1.3878
-#> 150:    94.0242   -5.9760   -2.0176   -4.2182   -0.9773    0.1032    6.1483    4.9301    0.9944    3.2498    0.1807    0.2290    6.5662    1.3618
-#> 151:    93.9234   -5.8772   -2.0132   -4.2362   -0.9651    0.1058    7.2453    4.6836    0.9824    3.4860    0.1806    0.2175    6.2575    1.4370
-#> 152:    94.2513   -5.9391   -2.0814   -4.2278   -0.9753    0.1221    4.9753    3.4013    0.9808    3.3265    0.1836    0.1897    6.6966    1.3457
-#> 153:    93.9434   -6.1294   -2.0570   -4.2447   -0.9761    0.1527    5.0454    4.3115    0.9494    3.3663    0.1684    0.1680    5.9106    1.4777
-#> 154:    93.8141   -6.2749   -2.0366   -4.2383   -0.9835    0.1440    5.5466    5.3351    0.9320    3.3337    0.1731    0.1913    5.8842    1.4325
-#> 155:    94.1987   -6.1029   -2.0252   -4.2520   -0.9780    0.1132    7.1508    4.2713    0.9457    3.3428    0.1727    0.1691    6.1632    1.4658
-#> 156:    94.0626   -6.2640   -2.0263   -4.2461   -0.9854    0.1346    5.6296    5.1645    0.9423    3.3987    0.1697    0.1778    5.9631    1.4483
-#> 157:    93.9319   -6.1392   -2.0388   -4.2294   -0.9921    0.1265    5.6768    4.7366    0.9210    3.3673    0.1733    0.1789    5.9114    1.4976
-#> 158:    93.9123   -6.1970   -2.0165   -4.2241   -0.9924    0.1540    7.2552    4.7537    0.9369    3.2727    0.1805    0.1923    5.9324    1.5351
-#> 159:    93.9704   -6.4018   -2.0455   -4.2127   -0.9919    0.1413    7.7561    6.0732    0.9802    3.3376    0.1806    0.2260    6.4511    1.4227
-#> 160:    94.1967   -6.2985   -2.0412   -4.2264   -0.9795    0.1206    8.3836    6.1319    0.9689    3.4685    0.1792    0.2150    6.5116    1.4706
-#> 161:    94.3500   -6.1427   -2.0189   -4.2242   -1.0022    0.0837    8.0282    4.5505    0.9524    3.3269    0.1859    0.1816    6.0642    1.4746
-#> 162:    94.2711   -5.9578   -2.0215   -4.2078   -1.0110    0.0946    7.8634    3.3072    0.9559    3.2374    0.1876    0.1791    6.0798    1.4903
-#> 163:    93.9824   -5.8794   -2.0409   -4.2367   -0.9970    0.1150    9.3872    3.0498    0.9830    3.3179    0.1880    0.1828    5.8091    1.4852
-#> 164:    94.2013   -5.8651   -2.0122   -4.2257   -0.9906    0.1267    7.1953    3.0510    0.9697    3.2713    0.1871    0.1832    5.8741    1.5313
-#> 165:    94.1804   -5.7868   -2.0200   -4.2053   -0.9812    0.1219    6.7375    2.4769    0.9688    3.2706    0.1910    0.1859    5.7890    1.5188
-#> 166:    93.9790   -5.8156   -2.0311   -4.2438   -0.9784    0.1247    5.7617    2.6907    0.9533    3.5342    0.1953    0.1872    5.8816    1.5243
-#> 167:    93.2524   -5.8603   -2.0497   -4.2594   -0.9787    0.1265    4.7086    2.9121    0.9117    3.4696    0.1943    0.1832    5.9672    1.4567
-#> 168:    93.2924   -6.0371   -2.0528   -4.2607   -0.9727    0.1201    5.5273    4.0286    0.9177    3.4501    0.1918    0.1908    5.7790    1.4701
-#> 169:    93.4838   -6.1497   -2.0389   -4.2716   -0.9639    0.1127    5.4524    4.2700    0.9544    3.4329    0.1940    0.1871    5.7795    1.4575
-#> 170:    93.3951   -6.2298   -2.0438   -4.4133   -0.9939    0.1088    6.1460    4.6552    0.9645    4.5240    0.1978    0.2091    5.7549    1.5233
-#> 171:    93.4113   -6.1187   -2.0536   -4.4019   -0.9771    0.0899    6.8123    4.0073    0.9531    4.4290    0.1878    0.1970    5.9067    1.4857
-#> 172:    93.1140   -5.9515   -2.0530   -4.3250   -0.9723    0.1094    5.1247    3.4502    0.9572    3.8504    0.1954    0.1944    5.8583    1.4867
-#> 173:    92.9782   -6.0415   -2.0633   -4.2887   -0.9608    0.1081    4.1020    3.8967    0.9478    3.7222    0.1890    0.1812    5.9473    1.4583
-#> 174:    92.9661   -5.9295   -2.0457   -4.2907   -0.9626    0.0991    5.7954    3.3581    0.9785    3.7311    0.1867    0.2026    5.8087    1.4797
-#> 175:    93.2577   -5.8895   -2.0281   -4.2845   -0.9560    0.0829    7.3434    3.1501    0.9975    3.6334    0.1920    0.2151    5.4717    1.4832
-#> 176:    93.1210   -5.9567   -2.0370   -4.2848   -0.9488    0.0787    6.8946    3.4999    0.9983    3.6159    0.1922    0.2233    5.8426    1.4096
-#> 177:    92.5456   -6.1797   -2.0319   -4.2684   -0.9401    0.0873    6.9744    5.2939    0.9928    3.4880    0.1989    0.2213    5.9613    1.4367
-#> 178:    92.6854   -6.1483   -2.0278   -4.2705   -0.9504    0.0630    5.0582    5.0622    0.9953    3.4915    0.1930    0.2238    5.9775    1.4263
-#> 179:    93.1323   -6.1739   -2.0353   -4.2590   -0.9455    0.0584    4.9914    4.7898    0.9817    3.4163    0.1899    0.2124    5.9579    1.4242
-#> 180:    93.0611   -6.2228   -2.0441   -4.2977   -0.9387    0.0320    4.0323    5.5685    0.9890    3.7202    0.1940    0.2335    6.2224    1.4194
-#> 181:    92.7741   -6.1462   -2.0477   -4.3335   -0.9454    0.1011    3.7007    5.1590    0.9807    3.8469    0.1939    0.2463    5.9703    1.4343
-#> 182:    93.0775   -6.0640   -2.0496   -4.3171   -0.9444    0.0897    5.0266    4.5597    0.9792    3.7741    0.1931    0.2186    5.6727    1.4858
-#> 183:    93.2566   -6.1757   -2.0368   -4.2888   -0.9560    0.0809    5.8284    5.2504    0.9636    3.7078    0.1939    0.2262    5.5170    1.4560
-#> 184:    93.0357   -6.1158   -2.0217   -4.3111   -0.9453    0.0901    6.7209    5.4048    0.9503    3.8949    0.1967    0.2209    5.3578    1.4704
-#> 185:    93.0173   -6.1998   -2.0371   -4.3713   -0.9451    0.0752    6.1040    5.8272    0.9333    4.4038    0.1951    0.2238    5.5896    1.4202
-#> 186:    93.2835   -6.1217   -2.0383   -4.3308   -0.9574    0.1110    6.0519    4.7669    0.9400    4.0265    0.1972    0.2274    5.4560    1.4602
-#> 187:    93.5312   -6.3356   -2.0253   -4.3418   -0.9583    0.1166    6.7561    5.8784    0.9346    4.0264    0.2038    0.2281    5.5024    1.4994
-#> 188:    93.6460   -5.8426   -2.0237   -4.4519   -0.9594    0.1283    6.3492    3.4189    0.9091    4.9358    0.2086    0.2348    5.4301    1.5893
-#> 189:    93.8538   -6.0183   -2.0178   -4.3911   -0.9797    0.1262    8.7939    3.7358    0.9008    4.4894    0.2125    0.2199    5.6613    1.5073
-#> 190:    93.1543   -6.1364   -2.0451   -4.4389   -0.9708    0.1584    9.9803    4.2747    0.8922    4.8507    0.2084    0.2607    5.9136    1.4572
-#> 191:    93.4334   -6.1466   -2.0389   -4.4661   -0.9678    0.1565    7.8390    4.4393    0.9022    4.7857    0.2105    0.2634    5.7161    1.5325
-#> 192:    93.3623   -6.0940   -2.0240   -4.4569   -0.9673    0.1420    8.0856    4.3185    0.8895    4.4721    0.2113    0.2350    5.5282    1.5221
-#> 193:    93.1990   -5.9864   -2.0301   -4.4538   -0.9563    0.1515    8.4425    3.7598    0.8814    4.4376    0.2013    0.2257    5.4205    1.4820
-#> 194:    93.3165   -6.0045   -2.0353   -4.4314   -0.9525    0.1486    8.2370    3.6742    0.8947    4.4594    0.1960    0.2248    5.4579    1.4767
-#> 195:    93.1288   -6.1006   -2.0551   -4.5184   -0.9503    0.1583    9.6259    4.2294    0.9040    5.1981    0.1950    0.1962    5.5602    1.4254
-#> 196:    93.1943   -5.9871   -2.0607   -4.4728   -0.9446    0.1482    9.3401    3.5579    0.8925    4.7901    0.1892    0.1879    5.7296    1.4172
-#> 197:    93.5803   -5.9131   -2.0522   -4.3675   -0.9476    0.1571    7.2599    3.4241    0.8857    3.8551    0.1886    0.1793    5.4832    1.6006
-#> 198:    93.5703   -5.9980   -2.0550   -4.3578   -0.9519    0.1491    7.0416    3.8805    0.8563    3.7930    0.1882    0.1896    5.4355    1.5402
-#> 199:    93.2909   -5.8288   -2.0532   -4.3605   -0.9518    0.1692    8.3926    3.0173    0.8566    3.8610    0.1902    0.2033    5.5735    1.5647
-#> 200:    93.4049   -5.7474   -2.0447   -4.3548   -0.9517    0.1812    7.4977    2.8256    0.8520    3.8236    0.1897    0.2060    5.5092    1.5699
-#> 201:    93.3386   -5.8209   -2.0398   -4.4174   -0.9597    0.1738    6.3555    3.0871    0.8431    4.3211    0.1853    0.2062    5.5460    1.5925
-#> 202:    93.3397   -5.8313   -2.0387   -4.4364   -0.9580    0.1669    6.0946    3.1018    0.8460    4.5093    0.1821    0.2068    5.6622    1.5740
-#> 203:    93.3071   -5.8276   -2.0384   -4.4758   -0.9571    0.1639    5.7815    3.0575    0.8608    4.9441    0.1826    0.2052    5.6855    1.5570
-#> 204:    93.3138   -5.8477   -2.0368   -4.4714   -0.9541    0.1658    5.7526    3.1322    0.8704    4.9129    0.1816    0.2057    5.6642    1.5606
-#> 205:    93.3066   -5.8537   -2.0395   -4.4842   -0.9521    0.1642    5.6045    3.1633    0.8748    5.0053    0.1805    0.2036    5.6633    1.5550
-#> 206:    93.3042   -5.8790   -2.0453   -4.4977   -0.9501    0.1633    5.7219    3.3320    0.8807    5.1121    0.1793    0.1999    5.6888    1.5413
-#> 207:    93.3281   -5.9005   -2.0504   -4.5109   -0.9480    0.1629    5.8004    3.4696    0.8865    5.2248    0.1789    0.1961    5.7206    1.5357
-#> 208:    93.3437   -5.8972   -2.0569   -4.5200   -0.9452    0.1641    5.7523    3.4604    0.8875    5.2848    0.1787    0.1933    5.7450    1.5288
-#> 209:    93.3265   -5.8864   -2.0628   -4.5092   -0.9440    0.1639    5.5355    3.4138    0.8882    5.1586    0.1791    0.1916    5.7744    1.5283
-#> 210:    93.3087   -5.8812   -2.0671   -4.5004   -0.9426    0.1677    5.3488    3.3975    0.8895    5.0589    0.1798    0.1924    5.7781    1.5307
-#> 211:    93.2807   -5.8760   -2.0703   -4.5009   -0.9413    0.1709    5.2654    3.3770    0.8894    5.0377    0.1805    0.1927    5.7808    1.5282
-#> 212:    93.2815   -5.8637   -2.0711   -4.4955   -0.9409    0.1708    5.3028    3.3250    0.8914    4.9702    0.1819    0.1941    5.7827    1.5274
-#> 213:    93.2828   -5.8481   -2.0709   -4.4895   -0.9396    0.1702    5.3840    3.2614    0.8913    4.9108    0.1826    0.1953    5.7744    1.5301
-#> 214:    93.2645   -5.8422   -2.0704   -4.4882   -0.9384    0.1710    5.3939    3.2358    0.8931    4.8944    0.1828    0.1955    5.7797    1.5351
-#> 215:    93.2591   -5.8519   -2.0709   -4.4858   -0.9380    0.1713    5.5142    3.2959    0.8953    4.8587    0.1822    0.1960    5.7853    1.5369
-#> 216:    93.2595   -5.8523   -2.0715   -4.4827   -0.9376    0.1723    5.5563    3.3077    0.8964    4.8306    0.1817    0.1973    5.7975    1.5396
-#> 217:    93.2503   -5.8512   -2.0732   -4.4737   -0.9373    0.1734    5.5036    3.3182    0.8959    4.7582    0.1817    0.1992    5.7940    1.5365
-#> 218:    93.2345   -5.8463   -2.0749   -4.4639   -0.9372    0.1747    5.5046    3.2959    0.8959    4.6771    0.1817    0.2008    5.7889    1.5340
-#> 219:    93.2264   -5.8439   -2.0757   -4.4549   -0.9364    0.1759    5.4970    3.2802    0.8966    4.6015    0.1819    0.2027    5.7804    1.5321
-#> 220:    93.2259   -5.8464   -2.0758   -4.4493   -0.9363    0.1771    5.4793    3.2944    0.8950    4.5498    0.1823    0.2049    5.7745    1.5344
-#> 221:    93.2243   -5.8505   -2.0768   -4.4443   -0.9367    0.1785    5.5360    3.3132    0.8924    4.5028    0.1829    0.2068    5.7556    1.5329
-#> 222:    93.2385   -5.8603   -2.0776   -4.4371   -0.9376    0.1800    5.5401    3.3878    0.8903    4.4416    0.1834    0.2096    5.7522    1.5317
-#> 223:    93.2339   -5.8634   -2.0780   -4.4309   -0.9377    0.1803    5.5522    3.4132    0.8882    4.3844    0.1838    0.2118    5.7457    1.5323
-#> 224:    93.2379   -5.8686   -2.0778   -4.4262   -0.9374    0.1803    5.5469    3.4421    0.8848    4.3375    0.1842    0.2137    5.7429    1.5323
-#> 225:    93.2329   -5.8654   -2.0784   -4.4222   -0.9373    0.1811    5.5553    3.4255    0.8843    4.2952    0.1848    0.2160    5.7452    1.5295
-#> 226:    93.2330   -5.8621   -2.0789   -4.4182   -0.9366    0.1816    5.5838    3.4123    0.8838    4.2565    0.1858    0.2176    5.7453    1.5284
-#> 227:    93.2309   -5.8549   -2.0794   -4.4153   -0.9365    0.1823    5.6720    3.3787    0.8827    4.2227    0.1866    0.2181    5.7339    1.5287
-#> 228:    93.2248   -5.8556   -2.0794   -4.4116   -0.9372    0.1832    5.7344    3.3780    0.8830    4.1863    0.1873    0.2200    5.7232    1.5308
-#> 229:    93.2215   -5.8615   -2.0798   -4.4081   -0.9373    0.1844    5.8478    3.4087    0.8821    4.1558    0.1878    0.2217    5.7174    1.5283
-#> 230:    93.2122   -5.8646   -2.0807   -4.4053   -0.9372    0.1858    5.8987    3.4233    0.8800    4.1288    0.1881    0.2233    5.7073    1.5272
-#> 231:    93.2080   -5.8665   -2.0816   -4.4025   -0.9372    0.1872    5.9544    3.4381    0.8782    4.1008    0.1883    0.2250    5.7006    1.5283
-#> 232:    93.1921   -5.8677   -2.0829   -4.3997   -0.9370    0.1887    5.9768    3.4440    0.8770    4.0748    0.1883    0.2268    5.7012    1.5261
-#> 233:    93.1794   -5.8674   -2.0840   -4.3972   -0.9363    0.1892    6.0074    3.4397    0.8757    4.0495    0.1884    0.2281    5.6997    1.5235
-#> 234:    93.1623   -5.8677   -2.0853   -4.3959   -0.9358    0.1898    5.9759    3.4442    0.8750    4.0330    0.1887    0.2295    5.7000    1.5223
-#> 235:    93.1499   -5.8709   -2.0862   -4.3918   -0.9356    0.1900    5.9951    3.4709    0.8747    4.0020    0.1891    0.2309    5.7002    1.5219
-#> 236:    93.1408   -5.8764   -2.0875   -4.3879   -0.9349    0.1898    6.0359    3.5027    0.8752    3.9720    0.1895    0.2321    5.7098    1.5196
-#> 237:    93.1307   -5.8766   -2.0887   -4.3843   -0.9344    0.1896    6.0589    3.5108    0.8755    3.9437    0.1900    0.2330    5.7176    1.5174
-#> 238:    93.1233   -5.8767   -2.0889   -4.3806   -0.9341    0.1891    6.0959    3.5158    0.8745    3.9173    0.1907    0.2339    5.7198    1.5169
-#> 239:    93.1245   -5.8810   -2.0889   -4.3775   -0.9337    0.1885    6.1196    3.5614    0.8746    3.8935    0.1915    0.2349    5.7177    1.5172
-#> 240:    93.1180   -5.8836   -2.0893   -4.3745   -0.9332    0.1883    6.1647    3.6004    0.8741    3.8709    0.1921    0.2360    5.7150    1.5192
-#> 241:    93.1096   -5.8838   -2.0898   -4.3714   -0.9327    0.1883    6.2283    3.6196    0.8743    3.8487    0.1927    0.2366    5.7177    1.5202
-#> 242:    93.1058   -5.8804   -2.0912   -4.3684   -0.9320    0.1888    6.2553    3.6018    0.8723    3.8274    0.1933    0.2378    5.7265    1.5198
-#> 243:    93.0953   -5.8762   -2.0924   -4.3668   -0.9315    0.1892    6.2692    3.5785    0.8705    3.8130    0.1940    0.2391    5.7353    1.5205
-#> 244:    93.0840   -5.8758   -2.0928   -4.3658   -0.9310    0.1889    6.2702    3.5746    0.8695    3.8007    0.1947    0.2401    5.7382    1.5205
-#> 245:    93.0720   -5.8795   -2.0933   -4.3647   -0.9306    0.1895    6.3022    3.5971    0.8685    3.7886    0.1953    0.2407    5.7367    1.5192
-#> 246:    93.0626   -5.8798   -2.0933   -4.3637   -0.9301    0.1898    6.2987    3.5992    0.8680    3.7781    0.1957    0.2410    5.7331    1.5184
-#> 247:    93.0526   -5.8805   -2.0934   -4.3610   -0.9298    0.1903    6.3067    3.6060    0.8682    3.7618    0.1963    0.2414    5.7329    1.5189
-#> 248:    93.0481   -5.8780   -2.0933   -4.3583   -0.9296    0.1911    6.3135    3.6007    0.8683    3.7460    0.1967    0.2420    5.7344    1.5191
-#> 249:    93.0483   -5.8762   -2.0933   -4.3558   -0.9294    0.1913    6.3095    3.5961    0.8685    3.7298    0.1970    0.2422    5.7414    1.5179
-#> 250:    93.0520   -5.8768   -2.0931   -4.3538   -0.9292    0.1912    6.2900    3.6003    0.8692    3.7176    0.1973    0.2424    5.7547    1.5148
-#> 251:    93.0430   -5.8769   -2.0930   -4.3516   -0.9291    0.1905    6.2815    3.6041    0.8704    3.7045    0.1975    0.2427    5.7653    1.5123
-#> 252:    93.0300   -5.8743   -2.0928   -4.3490   -0.9291    0.1901    6.2896    3.5885    0.8716    3.6919    0.1978    0.2428    5.7797    1.5106
-#> 253:    93.0217   -5.8740   -2.0926   -4.3468   -0.9289    0.1898    6.3238    3.5875    0.8731    3.6817    0.1981    0.2429    5.7885    1.5102
-#> 254:    93.0147   -5.8729   -2.0924   -4.3439   -0.9289    0.1892    6.3418    3.5857    0.8732    3.6683    0.1980    0.2426    5.7912    1.5102
-#> 255:    93.0144   -5.8743   -2.0922   -4.3407   -0.9290    0.1885    6.3755    3.5933    0.8735    3.6580    0.1979    0.2420    5.7932    1.5086
-#> 256:    93.0136   -5.8778   -2.0919   -4.3376   -0.9290    0.1876    6.3932    3.6240    0.8741    3.6481    0.1980    0.2418    5.7969    1.5066
-#> 257:    93.0116   -5.8792   -2.0917   -4.3345   -0.9291    0.1862    6.4096    3.6459    0.8744    3.6385    0.1980    0.2414    5.7990    1.5065
-#> 258:    93.0084   -5.8812   -2.0913   -4.3319   -0.9290    0.1842    6.4231    3.6686    0.8753    3.6281    0.1980    0.2414    5.8024    1.5050
-#> 259:    93.0090   -5.8866   -2.0909   -4.3293   -0.9287    0.1825    6.4361    3.7063    0.8762    3.6181    0.1981    0.2413    5.8106    1.5030
-#> 260:    93.0067   -5.8911   -2.0902   -4.3265   -0.9283    0.1811    6.4128    3.7384    0.8765    3.6076    0.1981    0.2412    5.8102    1.5026
-#> 261:    93.0060   -5.8933   -2.0894   -4.3237   -0.9284    0.1799    6.4253    3.7604    0.8765    3.5968    0.1981    0.2410    5.8080    1.5026
-#> 262:    93.0051   -5.8934   -2.0884   -4.3208   -0.9285    0.1789    6.4008    3.7597    0.8762    3.5855    0.1981    0.2412    5.8046    1.5020
-#> 263:    93.0019   -5.8945   -2.0875   -4.3182   -0.9287    0.1781    6.3788    3.7644    0.8758    3.5756    0.1982    0.2411    5.8048    1.5023
-#> 264:    93.0021   -5.8959   -2.0870   -4.3158   -0.9293    0.1773    6.3614    3.7682    0.8749    3.5667    0.1983    0.2410    5.8017    1.5021
-#> 265:    93.0053   -5.8989   -2.0866   -4.3130   -0.9296    0.1766    6.3506    3.7814    0.8739    3.5567    0.1982    0.2409    5.7995    1.5018
-#> 266:    93.0061   -5.8992   -2.0864   -4.3104   -0.9300    0.1757    6.3307    3.7730    0.8733    3.5471    0.1982    0.2408    5.7994    1.5012
-#> 267:    93.0098   -5.9009   -2.0861   -4.3077   -0.9302    0.1749    6.3326    3.7738    0.8730    3.5388    0.1983    0.2407    5.7964    1.5004
-#> 268:    93.0144   -5.9000   -2.0853   -4.3054   -0.9304    0.1740    6.3487    3.7623    0.8729    3.5290    0.1985    0.2405    5.7897    1.5014
-#> 269:    93.0146   -5.8984   -2.0847   -4.3032   -0.9306    0.1731    6.3716    3.7485    0.8735    3.5197    0.1985    0.2402    5.7867    1.5016
-#> 270:    93.0159   -5.8950   -2.0842   -4.3013   -0.9307    0.1722    6.3630    3.7266    0.8743    3.5098    0.1986    0.2400    5.7837    1.5016
-#> 271:    93.0161   -5.8925   -2.0837   -4.2995   -0.9309    0.1715    6.3539    3.7068    0.8744    3.5001    0.1986    0.2400    5.7843    1.5020
-#> 272:    93.0195   -5.8919   -2.0837   -4.2977   -0.9314    0.1710    6.3430    3.6964    0.8744    3.4922    0.1985    0.2400    5.7859    1.5031
-#> 273:    93.0184   -5.8923   -2.0837   -4.2961   -0.9318    0.1705    6.3531    3.6914    0.8743    3.4854    0.1984    0.2402    5.7880    1.5030
-#> 274:    93.0178   -5.8927   -2.0834   -4.2951   -0.9320    0.1701    6.3818    3.6865    0.8749    3.4824    0.1984    0.2403    5.7928    1.5020
-#> 275:    93.0204   -5.8937   -2.0833   -4.2942   -0.9324    0.1700    6.3961    3.6842    0.8754    3.4790    0.1984    0.2402    5.7949    1.5011
-#> 276:    93.0228   -5.8958   -2.0833   -4.2932   -0.9327    0.1699    6.3965    3.6870    0.8760    3.4752    0.1984    0.2402    5.7934    1.5002
-#> 277:    93.0251   -5.9000   -2.0833   -4.2921   -0.9329    0.1695    6.4076    3.7032    0.8766    3.4712    0.1985    0.2400    5.7979    1.4989
-#> 278:    93.0297   -5.9021   -2.0833   -4.2912   -0.9331    0.1690    6.4279    3.7073    0.8771    3.4671    0.1986    0.2399    5.7978    1.4981
-#> 279:    93.0273   -5.9021   -2.0832   -4.2902   -0.9332    0.1684    6.4349    3.7003    0.8779    3.4622    0.1988    0.2400    5.7993    1.4972
-#> 280:    93.0236   -5.9030   -2.0831   -4.2892   -0.9334    0.1674    6.4776    3.6986    0.8787    3.4576    0.1990    0.2401    5.8026    1.4963
-#> 281:    93.0172   -5.9037   -2.0829   -4.2881   -0.9337    0.1665    6.4942    3.6984    0.8797    3.4536    0.1992    0.2402    5.8056    1.4955
-#> 282:    93.0147   -5.9055   -2.0827   -4.2872   -0.9339    0.1656    6.4861    3.7031    0.8810    3.4492    0.1992    0.2403    5.8107    1.4954
-#> 283:    93.0138   -5.9053   -2.0824   -4.2865   -0.9341    0.1646    6.4962    3.6967    0.8822    3.4451    0.1993    0.2406    5.8142    1.4959
-#> 284:    93.0132   -5.9067   -2.0821   -4.2864   -0.9343    0.1636    6.5021    3.7013    0.8838    3.4437    0.1993    0.2406    5.8146    1.4955
-#> 285:    93.0138   -5.9081   -2.0819   -4.2859   -0.9343    0.1628    6.5037    3.7043    0.8851    3.4406    0.1994    0.2406    5.8146    1.4945
-#> 286:    93.0119   -5.9086   -2.0815   -4.2858   -0.9342    0.1620    6.5068    3.7037    0.8864    3.4395    0.1994    0.2404    5.8133    1.4936
-#> 287:    93.0122   -5.9089   -2.0813   -4.2860   -0.9342    0.1614    6.5202    3.7044    0.8872    3.4399    0.1997    0.2401    5.8096    1.4929
-#> 288:    93.0104   -5.9083   -2.0812   -4.2858   -0.9342    0.1609    6.5237    3.6997    0.8876    3.4376    0.1999    0.2398    5.8041    1.4924
-#> 289:    93.0076   -5.9066   -2.0812   -4.2854   -0.9342    0.1604    6.5121    3.6893    0.8881    3.4342    0.1999    0.2394    5.8021    1.4922
-#> 290:    93.0064   -5.9052   -2.0813   -4.2851   -0.9343    0.1602    6.5106    3.6772    0.8886    3.4309    0.2000    0.2389    5.7988    1.4915
-#> 291:    93.0071   -5.9031   -2.0813   -4.2849   -0.9345    0.1601    6.5031    3.6628    0.8891    3.4284    0.2000    0.2384    5.7959    1.4908
-#> 292:    93.0114   -5.9023   -2.0809   -4.2841   -0.9346    0.1594    6.4930    3.6538    0.8894    3.4237    0.2001    0.2383    5.7923    1.4902
-#> 293:    93.0148   -5.9032   -2.0807   -4.2834   -0.9348    0.1589    6.4836    3.6542    0.8898    3.4206    0.2002    0.2380    5.7893    1.4893
-#> 294:    93.0161   -5.9026   -2.0806   -4.2826   -0.9349    0.1582    6.4719    3.6469    0.8901    3.4176    0.2005    0.2375    5.7898    1.4886
-#> 295:    93.0212   -5.9008   -2.0806   -4.2817   -0.9350    0.1576    6.4649    3.6372    0.8904    3.4145    0.2007    0.2370    5.7885    1.4890
-#> 296:    93.0270   -5.8989   -2.0805   -4.2809   -0.9351    0.1569    6.4835    3.6279    0.8911    3.4124    0.2010    0.2366    5.7886    1.4884
-#> 297:    93.0291   -5.8969   -2.0803   -4.2800   -0.9352    0.1560    6.5014    3.6177    0.8915    3.4094    0.2012    0.2364    5.7873    1.4880
-#> 298:    93.0332   -5.8963   -2.0801   -4.2790   -0.9352    0.1551    6.5168    3.6111    0.8919    3.4065    0.2014    0.2361    5.7855    1.4875
-#> 299:    93.0339   -5.8961   -2.0799   -4.2782   -0.9352    0.1542    6.5288    3.6081    0.8927    3.4038    0.2015    0.2358    5.7844    1.4869
-#> 300:    93.0335   -5.8971   -2.0797   -4.2772   -0.9351    0.1533    6.5409    3.6097    0.8937    3.4009    0.2017    0.2356    5.7844    1.4859
-#> 301:    93.0320   -5.8979   -2.0796   -4.2762   -0.9350    0.1522    6.5553    3.6126    0.8945    3.3977    0.2020    0.2354    5.7898    1.4847
-#> 302:    93.0321   -5.8997   -2.0795   -4.2751   -0.9351    0.1513    6.5737    3.6195    0.8956    3.3943    0.2023    0.2351    5.7917    1.4835
-#> 303:    93.0328   -5.8984   -2.0792   -4.2739   -0.9351    0.1504    6.5888    3.6111    0.8964    3.3912    0.2025    0.2350    5.7915    1.4825
-#> 304:    93.0357   -5.8969   -2.0790   -4.2728   -0.9350    0.1494    6.5907    3.6018    0.8975    3.3882    0.2026    0.2348    5.7929    1.4813
-#> 305:    93.0351   -5.8953   -2.0786   -4.2718   -0.9349    0.1484    6.5764    3.5916    0.8986    3.3858    0.2027    0.2345    5.7937    1.4816
-#> 306:    93.0352   -5.8950   -2.0784   -4.2707   -0.9350    0.1475    6.5727    3.5890    0.8999    3.3835    0.2028    0.2341    5.7981    1.4810
-#> 307:    93.0354   -5.8947   -2.0784   -4.2699   -0.9351    0.1466    6.5759    3.5853    0.9010    3.3820    0.2030    0.2339    5.8028    1.4799
-#> 308:    93.0336   -5.8938   -2.0783   -4.2690   -0.9351    0.1459    6.5855    3.5776    0.9022    3.3809    0.2031    0.2333    5.8014    1.4788
-#> 309:    93.0311   -5.8931   -2.0780   -4.2683   -0.9351    0.1452    6.5799    3.5717    0.9038    3.3805    0.2033    0.2328    5.8048    1.4779
-#> 310:    93.0303   -5.8915   -2.0778   -4.2675   -0.9352    0.1447    6.5716    3.5609    0.9046    3.3797    0.2033    0.2323    5.8060    1.4774
-#> 311:    93.0275   -5.8915   -2.0776   -4.2668   -0.9352    0.1441    6.5679    3.5581    0.9052    3.3788    0.2034    0.2319    5.8056    1.4770
-#> 312:    93.0258   -5.8920   -2.0775   -4.2659   -0.9352    0.1435    6.5573    3.5571    0.9058    3.3775    0.2033    0.2314    5.8053    1.4766
-#> 313:    93.0234   -5.8928   -2.0773   -4.2649   -0.9353    0.1431    6.5510    3.5573    0.9065    3.3761    0.2033    0.2309    5.8046    1.4757
-#> 314:    93.0237   -5.8937   -2.0771   -4.2639   -0.9355    0.1425    6.5488    3.5578    0.9074    3.3747    0.2033    0.2303    5.8029    1.4751
-#> 315:    93.0237   -5.8940   -2.0769   -4.2629   -0.9357    0.1420    6.5480    3.5565    0.9081    3.3730    0.2034    0.2299    5.8010    1.4746
-#> 316:    93.0218   -5.8936   -2.0767   -4.2617   -0.9358    0.1413    6.5424    3.5517    0.9087    3.3705    0.2034    0.2296    5.7992    1.4741
-#> 317:    93.0218   -5.8932   -2.0766   -4.2606   -0.9359    0.1406    6.5576    3.5474    0.9091    3.3679    0.2034    0.2292    5.7965    1.4736
-#> 318:    93.0215   -5.8927   -2.0765   -4.2597   -0.9361    0.1402    6.5884    3.5420    0.9096    3.3661    0.2034    0.2288    5.7960    1.4727
-#> 319:    93.0201   -5.8938   -2.0764   -4.2588   -0.9361    0.1397    6.6095    3.5439    0.9101    3.3642    0.2034    0.2283    5.7943    1.4719
-#> 320:    93.0188   -5.8926   -2.0763   -4.2579   -0.9361    0.1392    6.6170    3.5368    0.9103    3.3622    0.2034    0.2282    5.7930    1.4711
-#> 321:    93.0155   -5.8908   -2.0762   -4.2569   -0.9361    0.1385    6.6328    3.5268    0.9105    3.3598    0.2033    0.2282    5.7921    1.4702
-#> 322:    93.0133   -5.8894   -2.0760   -4.2561   -0.9360    0.1378    6.6415    3.5192    0.9110    3.3580    0.2032    0.2282    5.7903    1.4698
-#> 323:    93.0089   -5.8888   -2.0759   -4.2555   -0.9360    0.1372    6.6480    3.5131    0.9107    3.3563    0.2031    0.2285    5.7915    1.4691
-#> 324:    93.0038   -5.8881   -2.0758   -4.2547   -0.9359    0.1364    6.6639    3.5076    0.9106    3.3547    0.2029    0.2287    5.7912    1.4687
-#> 325:    93.0011   -5.8871   -2.0756   -4.2540   -0.9359    0.1361    6.6587    3.5005    0.9102    3.3531    0.2028    0.2289    5.7896    1.4686
-#> 326:    93.0033   -5.8874   -2.0755   -4.2535   -0.9360    0.1360    6.6621    3.4995    0.9098    3.3510    0.2026    0.2294    5.7883    1.4686
-#> 327:    93.0039   -5.8885   -2.0754   -4.2532   -0.9361    0.1359    6.6589    3.5051    0.9093    3.3497    0.2025    0.2297    5.7869    1.4687
-#> 328:    93.0061   -5.8896   -2.0753   -4.2529   -0.9362    0.1355    6.6671    3.5132    0.9088    3.3484    0.2024    0.2299    5.7854    1.4687
-#> 329:    93.0077   -5.8915   -2.0755   -4.2525   -0.9363    0.1352    6.6719    3.5255    0.9085    3.3464    0.2024    0.2301    5.7850    1.4682
-#> 330:    93.0061   -5.8942   -2.0757   -4.2518   -0.9365    0.1351    6.6696    3.5399    0.9083    3.3438    0.2023    0.2302    5.7840    1.4680
-#> 331:    93.0032   -5.8953   -2.0759   -4.2513   -0.9366    0.1348    6.6554    3.5433    0.9080    3.3411    0.2022    0.2302    5.7839    1.4677
-#> 332:    93.0013   -5.8956   -2.0761   -4.2507   -0.9367    0.1347    6.6298    3.5423    0.9079    3.3385    0.2021    0.2302    5.7851    1.4672
-#> 333:    93.0026   -5.8950   -2.0764   -4.2502   -0.9368    0.1346    6.6207    3.5365    0.9078    3.3357    0.2021    0.2303    5.7849    1.4667
-#> 334:    93.0019   -5.8933   -2.0767   -4.2497   -0.9369    0.1348    6.6145    3.5259    0.9077    3.3330    0.2021    0.2302    5.7856    1.4662
-#> 335:    93.0038   -5.8930   -2.0768   -4.2492   -0.9370    0.1348    6.6200    3.5227    0.9078    3.3307    0.2020    0.2303    5.7845    1.4654
-#> 336:    93.0038   -5.8923   -2.0765   -4.2488   -0.9371    0.1348    6.6316    3.5180    0.9081    3.3291    0.2019    0.2304    5.7837    1.4654
-#> 337:    93.0074   -5.8927   -2.0764   -4.2485   -0.9373    0.1349    6.6509    3.5187    0.9083    3.3275    0.2018    0.2304    5.7808    1.4655
-#> 338:    93.0117   -5.8950   -2.0761   -4.2483   -0.9377    0.1349    6.6559    3.5291    0.9087    3.3263    0.2018    0.2303    5.7770    1.4657
-#> 339:    93.0172   -5.8960   -2.0759   -4.2482   -0.9380    0.1349    6.6610    3.5304    0.9090    3.3260    0.2017    0.2302    5.7744    1.4657
-#> 340:    93.0179   -5.8977   -2.0757   -4.2481   -0.9383    0.1349    6.6583    3.5340    0.9093    3.3263    0.2017    0.2301    5.7749    1.4650
-#> 341:    93.0201   -5.8986   -2.0755   -4.2484   -0.9386    0.1348    6.6603    3.5337    0.9092    3.3283    0.2018    0.2300    5.7738    1.4650
-#> 342:    93.0245   -5.8990   -2.0752   -4.2484   -0.9389    0.1348    6.6680    3.5324    0.9093    3.3297    0.2018    0.2300    5.7727    1.4649
-#> 343:    93.0302   -5.9006   -2.0751   -4.2484   -0.9391    0.1347    6.6715    3.5367    0.9093    3.3313    0.2017    0.2300    5.7729    1.4645
-#> 344:    93.0340   -5.9026   -2.0749   -4.2484   -0.9394    0.1346    6.6793    3.5438    0.9093    3.3326    0.2017    0.2301    5.7709    1.4646
-#> 345:    93.0372   -5.9049   -2.0746   -4.2484   -0.9397    0.1347    6.6874    3.5515    0.9090    3.3340    0.2017    0.2301    5.7688    1.4648
-#> 346:    93.0372   -5.9063   -2.0743   -4.2483   -0.9399    0.1348    6.6963    3.5592    0.9090    3.3348    0.2018    0.2299    5.7680    1.4656
-#> 347:    93.0383   -5.9075   -2.0742   -4.2481   -0.9402    0.1350    6.7101    3.5658    0.9093    3.3353    0.2018    0.2299    5.7672    1.4649
-#> 348:    93.0412   -5.9084   -2.0742   -4.2479   -0.9405    0.1351    6.7183    3.5707    0.9095    3.3356    0.2019    0.2297    5.7657    1.4645
-#> 349:    93.0436   -5.9097   -2.0742   -4.2477   -0.9407    0.1351    6.7143    3.5783    0.9098    3.3359    0.2019    0.2295    5.7646    1.4643
-#> 350:    93.0476   -5.9105   -2.0742   -4.2474   -0.9409    0.1351    6.7239    3.5808    0.9100    3.3354    0.2019    0.2294    5.7628    1.4639
-#> 351:    93.0506   -5.9113   -2.0741   -4.2473   -0.9411    0.1352    6.7270    3.5825    0.9103    3.3356    0.2019    0.2292    5.7604    1.4637
-#> 352:    93.0529   -5.9127   -2.0740   -4.2471   -0.9413    0.1353    6.7312    3.5886    0.9107    3.3358    0.2019    0.2290    5.7594    1.4634
-#> 353:    93.0580   -5.9139   -2.0739   -4.2470   -0.9415    0.1354    6.7315    3.5922    0.9111    3.3357    0.2019    0.2288    5.7571    1.4636
-#> 354:    93.0639   -5.9129   -2.0738   -4.2468   -0.9417    0.1354    6.7390    3.5876    0.9112    3.3356    0.2018    0.2286    5.7541    1.4642
-#> 355:    93.0671   -5.9131   -2.0737   -4.2467   -0.9417    0.1353    6.7348    3.5906    0.9113    3.3354    0.2017    0.2284    5.7520    1.4648
-#> 356:    93.0682   -5.9134   -2.0737   -4.2465   -0.9418    0.1352    6.7329    3.5962    0.9113    3.3353    0.2017    0.2283    5.7505    1.4649
-#> 357:    93.0698   -5.9128   -2.0738   -4.2471   -0.9418    0.1354    6.7397    3.5933    0.9115    3.3388    0.2016    0.2280    5.7512    1.4651
-#> 358:    93.0709   -5.9129   -2.0740   -4.2475   -0.9419    0.1355    6.7379    3.5915    0.9119    3.3416    0.2016    0.2278    5.7526    1.4644
-#> 359:    93.0718   -5.9128   -2.0742   -4.2478   -0.9419    0.1358    6.7428    3.5886    0.9123    3.3432    0.2015    0.2275    5.7516    1.4641
-#> 360:    93.0693   -5.9136   -2.0743   -4.2481   -0.9419    0.1360    6.7385    3.5930    0.9125    3.3443    0.2015    0.2272    5.7511    1.4636
-#> 361:    93.0674   -5.9148   -2.0744   -4.2484   -0.9419    0.1361    6.7230    3.6002    0.9127    3.3458    0.2015    0.2270    5.7514    1.4634
-#> 362:    93.0660   -5.9168   -2.0745   -4.2486   -0.9420    0.1361    6.7313    3.6117    0.9130    3.3473    0.2014    0.2270    5.7506    1.4636
-#> 363:    93.0635   -5.9196   -2.0746   -4.2490   -0.9421    0.1360    6.7388    3.6275    0.9132    3.3500    0.2014    0.2269    5.7493    1.4636
-#> 364:    93.0631   -5.9210   -2.0747   -4.2497   -0.9421    0.1361    6.7383    3.6323    0.9135    3.3548    0.2015    0.2268    5.7483    1.4634
-#> 365:    93.0635   -5.9219   -2.0747   -4.2504   -0.9421    0.1361    6.7402    3.6341    0.9137    3.3590    0.2015    0.2268    5.7461    1.4635
-#> 366:    93.0640   -5.9232   -2.0746   -4.2511   -0.9422    0.1362    6.7477    3.6409    0.9142    3.3624    0.2015    0.2267    5.7451    1.4641
-#> 367:    93.0616   -5.9247   -2.0746   -4.2518   -0.9422    0.1364    6.7557    3.6473    0.9148    3.3653    0.2015    0.2269    5.7472    1.4640
-#> 368:    93.0601   -5.9247   -2.0746   -4.2522   -0.9422    0.1366    6.7632    3.6452    0.9150    3.3678    0.2015    0.2270    5.7482    1.4639
-#> 369:    93.0583   -5.9240   -2.0748   -4.2527   -0.9423    0.1369    6.7737    3.6395    0.9148    3.3695    0.2015    0.2273    5.7499    1.4636
-#> 370:    93.0591   -5.9236   -2.0752   -4.2532   -0.9423    0.1373    6.7721    3.6352    0.9145    3.3718    0.2015    0.2276    5.7513    1.4636
-#> 371:    93.0607   -5.9235   -2.0755   -4.2540   -0.9424    0.1378    6.7682    3.6330    0.9143    3.3754    0.2015    0.2280    5.7535    1.4635
-#> 372:    93.0615   -5.9229   -2.0759   -4.2549   -0.9424    0.1382    6.7640    3.6288    0.9142    3.3795    0.2014    0.2284    5.7553    1.4633
-#> 373:    93.0612   -5.9237   -2.0763   -4.2557   -0.9424    0.1385    6.7641    3.6327    0.9140    3.3832    0.2012    0.2288    5.7570    1.4629
-#> 374:    93.0611   -5.9240   -2.0766   -4.2565   -0.9424    0.1389    6.7701    3.6341    0.9137    3.3872    0.2011    0.2293    5.7599    1.4625
-#> 375:    93.0615   -5.9247   -2.0770   -4.2573   -0.9424    0.1393    6.7729    3.6362    0.9134    3.3912    0.2009    0.2296    5.7629    1.4620
-#> 376:    93.0621   -5.9248   -2.0772   -4.2578   -0.9425    0.1397    6.7732    3.6371    0.9132    3.3931    0.2008    0.2298    5.7654    1.4613
-#> 377:    93.0622   -5.9255   -2.0774   -4.2582   -0.9426    0.1401    6.7681    3.6389    0.9130    3.3953    0.2007    0.2300    5.7678    1.4607
-#> 378:    93.0609   -5.9256   -2.0775   -4.2585   -0.9426    0.1402    6.7705    3.6381    0.9128    3.3972    0.2006    0.2301    5.7673    1.4602
-#> 379:    93.0590   -5.9262   -2.0776   -4.2589   -0.9426    0.1404    6.7777    3.6382    0.9127    3.3991    0.2005    0.2303    5.7668    1.4599
-#> 380:    93.0607   -5.9258   -2.0777   -4.2595   -0.9427    0.1407    6.7836    3.6350    0.9127    3.4031    0.2004    0.2305    5.7665    1.4598
-#> 381:    93.0617   -5.9251   -2.0777   -4.2596   -0.9427    0.1410    6.7880    3.6294    0.9125    3.4030    0.2003    0.2307    5.7651    1.4601
-#> 382:    93.0631   -5.9252   -2.0777   -4.2599   -0.9428    0.1413    6.7912    3.6278    0.9123    3.4038    0.2002    0.2310    5.7649    1.4606
-#> 383:    93.0621   -5.9253   -2.0778   -4.2602   -0.9429    0.1415    6.7834    3.6279    0.9119    3.4053    0.2000    0.2312    5.7657    1.4607
-#> 384:    93.0614   -5.9254   -2.0779   -4.2604   -0.9430    0.1416    6.7853    3.6280    0.9115    3.4066    0.1999    0.2313    5.7662    1.4608
-#> 385:    93.0613   -5.9259   -2.0780   -4.2605   -0.9430    0.1418    6.7757    3.6301    0.9112    3.4066    0.1997    0.2315    5.7678    1.4609
-#> 386:    93.0614   -5.9264   -2.0780   -4.2607   -0.9431    0.1418    6.7610    3.6331    0.9110    3.4073    0.1995    0.2317    5.7696    1.4612
-#> 387:    93.0631   -5.9276   -2.0780   -4.2610   -0.9432    0.1420    6.7595    3.6397    0.9108    3.4085    0.1993    0.2318    5.7716    1.4612
-#> 388:    93.0650   -5.9282   -2.0779   -4.2613   -0.9433    0.1421    6.7552    3.6445    0.9106    3.4092    0.1992    0.2318    5.7731    1.4612
-#> 389:    93.0644   -5.9286   -2.0779   -4.2616   -0.9434    0.1422    6.7488    3.6471    0.9104    3.4098    0.1991    0.2317    5.7724    1.4614
-#> 390:    93.0653   -5.9297   -2.0778   -4.2619   -0.9435    0.1423    6.7412    3.6524    0.9101    3.4103    0.1990    0.2317    5.7722    1.4615
-#> 391:    93.0647   -5.9297   -2.0778   -4.2623   -0.9435    0.1425    6.7508    3.6524    0.9101    3.4115    0.1989    0.2317    5.7729    1.4621
-#> 392:    93.0637   -5.9293   -2.0778   -4.2624   -0.9436    0.1427    6.7572    3.6498    0.9102    3.4109    0.1988    0.2317    5.7727    1.4623
-#> 393:    93.0657   -5.9294   -2.0778   -4.2632   -0.9436    0.1429    6.7607    3.6496    0.9104    3.4148    0.1987    0.2318    5.7719    1.4621
-#> 394:    93.0689   -5.9293   -2.0779   -4.2635   -0.9438    0.1431    6.7635    3.6489    0.9108    3.4141    0.1987    0.2318    5.7724    1.4623
-#> 395:    93.0705   -5.9295   -2.0780   -4.2640   -0.9438    0.1433    6.7753    3.6500    0.9110    3.4145    0.1986    0.2319    5.7724    1.4622
-#> 396:    93.0704   -5.9296   -2.0780   -4.2648   -0.9438    0.1435    6.7793    3.6511    0.9112    3.4175    0.1985    0.2319    5.7720    1.4618
-#> 397:    93.0715   -5.9302   -2.0781   -4.2656   -0.9438    0.1437    6.7782    3.6530    0.9114    3.4206    0.1985    0.2320    5.7706    1.4617
-#> 398:    93.0719   -5.9297   -2.0781   -4.2666   -0.9438    0.1439    6.7774    3.6510    0.9120    3.4258    0.1984    0.2319    5.7709    1.4616
-#> 399:    93.0720   -5.9296   -2.0781   -4.2678   -0.9438    0.1441    6.7819    3.6526    0.9126    3.4317    0.1984    0.2319    5.7717    1.4615
-#> 400:    93.0730   -5.9296   -2.0783   -4.2691   -0.9438    0.1443    6.7786    3.6538    0.9129    3.4389    0.1983    0.2319    5.7716    1.4614
-#> 401:    93.0728   -5.9292   -2.0783   -4.2706   -0.9437    0.1445    6.7731    3.6521    0.9133    3.4478    0.1982    0.2319    5.7701    1.4615
-#> 402:    93.0732   -5.9289   -2.0784   -4.2718   -0.9438    0.1447    6.7698    3.6517    0.9137    3.4542    0.1981    0.2319    5.7689    1.4618
-#> 403:    93.0732   -5.9301   -2.0785   -4.2730   -0.9438    0.1450    6.7640    3.6576    0.9142    3.4593    0.1980    0.2320    5.7693    1.4615
-#> 404:    93.0710   -5.9316   -2.0787   -4.2740   -0.9439    0.1453    6.7544    3.6647    0.9147    3.4644    0.1979    0.2320    5.7708    1.4611
-#> 405:    93.0687   -5.9322   -2.0788   -4.2750   -0.9440    0.1454    6.7547    3.6663    0.9153    3.4693    0.1978    0.2322    5.7714    1.4608
-#> 406:    93.0673   -5.9337   -2.0789   -4.2760   -0.9440    0.1456    6.7563    3.6726    0.9163    3.4742    0.1977    0.2324    5.7718    1.4603
-#> 407:    93.0653   -5.9345   -2.0791   -4.2769   -0.9440    0.1456    6.7601    3.6756    0.9169    3.4786    0.1976    0.2327    5.7732    1.4598
-#> 408:    93.0640   -5.9357   -2.0793   -4.2779   -0.9440    0.1455    6.7547    3.6821    0.9177    3.4838    0.1974    0.2329    5.7751    1.4592
-#> 409:    93.0646   -5.9371   -2.0795   -4.2784   -0.9440    0.1456    6.7486    3.6915    0.9184    3.4863    0.1973    0.2330    5.7766    1.4588
-#> 410:    93.0639   -5.9391   -2.0797   -4.2791   -0.9441    0.1457    6.7523    3.7048    0.9192    3.4889    0.1972    0.2329    5.7770    1.4582
-#> 411:    93.0628   -5.9401   -2.0799   -4.2799   -0.9442    0.1457    6.7529    3.7113    0.9199    3.4929    0.1972    0.2329    5.7761    1.4580
-#> 412:    93.0620   -5.9402   -2.0801   -4.2808   -0.9443    0.1458    6.7502    3.7099    0.9207    3.4972    0.1971    0.2328    5.7767    1.4577
-#> 413:    93.0628   -5.9403   -2.0804   -4.2816   -0.9443    0.1461    6.7466    3.7091    0.9214    3.5007    0.1970    0.2326    5.7771    1.4572
-#> 414:    93.0627   -5.9405   -2.0807   -4.2825   -0.9443    0.1463    6.7480    3.7089    0.9221    3.5048    0.1969    0.2325    5.7774    1.4567
-#> 415:    93.0614   -5.9402   -2.0810   -4.2836   -0.9443    0.1465    6.7474    3.7066    0.9226    3.5098    0.1969    0.2323    5.7780    1.4564
-#> 416:    93.0610   -5.9408   -2.0813   -4.2848   -0.9443    0.1469    6.7544    3.7116    0.9229    3.5157    0.1968    0.2321    5.7786    1.4559
-#> 417:    93.0601   -5.9413   -2.0815   -4.2860   -0.9443    0.1471    6.7592    3.7158    0.9234    3.5206    0.1967    0.2319    5.7793    1.4556
-#> 418:    93.0606   -5.9424   -2.0817   -4.2868   -0.9444    0.1473    6.7589    3.7214    0.9238    3.5237    0.1966    0.2318    5.7787    1.4553
-#> 419:    93.0605   -5.9433   -2.0818   -4.2877   -0.9444    0.1476    6.7641    3.7253    0.9242    3.5274    0.1965    0.2316    5.7780    1.4552
-#> 420:    93.0623   -5.9427   -2.0819   -4.2886   -0.9445    0.1478    6.7593    3.7216    0.9246    3.5310    0.1965    0.2314    5.7772    1.4551
-#> 421:    93.0630   -5.9418   -2.0819   -4.2895   -0.9445    0.1480    6.7489    3.7166    0.9250    3.5337    0.1964    0.2312    5.7764    1.4552
-#> 422:    93.0626   -5.9410   -2.0820   -4.2900   -0.9445    0.1482    6.7452    3.7124    0.9253    3.5350    0.1963    0.2311    5.7758    1.4549
-#> 423:    93.0629   -5.9407   -2.0822   -4.2906   -0.9446    0.1484    6.7409    3.7095    0.9256    3.5360    0.1963    0.2309    5.7753    1.4546
-#> 424:    93.0637   -5.9404   -2.0821   -4.2912   -0.9446    0.1485    6.7387    3.7073    0.9258    3.5370    0.1962    0.2308    5.7733    1.4546
-#> 425:    93.0625   -5.9402   -2.0821   -4.2917   -0.9447    0.1486    6.7330    3.7061    0.9258    3.5381    0.1961    0.2306    5.7722    1.4548
-#> 426:    93.0624   -5.9399   -2.0820   -4.2921   -0.9447    0.1487    6.7256    3.7034    0.9259    3.5387    0.1961    0.2304    5.7719    1.4545
-#> 427:    93.0606   -5.9397   -2.0821   -4.2925   -0.9447    0.1488    6.7139    3.7010    0.9257    3.5394    0.1961    0.2301    5.7730    1.4545
-#> 428:    93.0601   -5.9394   -2.0822   -4.2929   -0.9447    0.1489    6.7062    3.6984    0.9256    3.5405    0.1961    0.2298    5.7723    1.4543
-#> 429:    93.0615   -5.9391   -2.0821   -4.2933   -0.9447    0.1490    6.7040    3.6956    0.9254    3.5412    0.1960    0.2297    5.7714    1.4544
-#> 430:    93.0654   -5.9389   -2.0820   -4.2934   -0.9448    0.1491    6.7016    3.6934    0.9253    3.5412    0.1960    0.2295    5.7710    1.4546
-#> 431:    93.0674   -5.9392   -2.0819   -4.2936   -0.9449    0.1491    6.6946    3.6935    0.9252    3.5414    0.1960    0.2294    5.7699    1.4547
-#> 432:    93.0683   -5.9401   -2.0818   -4.2938   -0.9450    0.1491    6.6895    3.6960    0.9250    3.5417    0.1961    0.2292    5.7687    1.4549
-#> 433:    93.0693   -5.9411   -2.0815   -4.2942   -0.9451    0.1491    6.6826    3.7003    0.9254    3.5433    0.1961    0.2291    5.7679    1.4549
-#> 434:    93.0720   -5.9410   -2.0813   -4.2945   -0.9452    0.1491    6.6842    3.6998    0.9258    3.5440    0.1960    0.2290    5.7662    1.4548
-#> 435:    93.0735   -5.9417   -2.0811   -4.2947   -0.9453    0.1490    6.6907    3.7029    0.9261    3.5446    0.1960    0.2290    5.7651    1.4548
-#> 436:    93.0752   -5.9430   -2.0809   -4.2949   -0.9454    0.1489    6.6939    3.7083    0.9266    3.5459    0.1959    0.2290    5.7638    1.4547
-#> 437:    93.0774   -5.9442   -2.0807   -4.2952   -0.9455    0.1487    6.7016    3.7147    0.9270    3.5474    0.1960    0.2290    5.7624    1.4550
-#> 438:    93.0795   -5.9453   -2.0805   -4.2954   -0.9456    0.1485    6.7089    3.7212    0.9275    3.5491    0.1959    0.2291    5.7614    1.4551
-#> 439:    93.0816   -5.9467   -2.0802   -4.2956   -0.9457    0.1484    6.7230    3.7291    0.9281    3.5503    0.1959    0.2293    5.7616    1.4551
-#> 440:    93.0834   -5.9475   -2.0800   -4.2957   -0.9458    0.1480    6.7306    3.7340    0.9287    3.5512    0.1960    0.2295    5.7631    1.4551
-#> 441:    93.0855   -5.9480   -2.0797   -4.2961   -0.9459    0.1478    6.7436    3.7373    0.9292    3.5534    0.1960    0.2299    5.7642    1.4553
-#> 442:    93.0885   -5.9488   -2.0793   -4.2963   -0.9460    0.1474    6.7533    3.7419    0.9297    3.5546    0.1960    0.2304    5.7630    1.4554
-#> 443:    93.0907   -5.9497   -2.0789   -4.2967   -0.9461    0.1471    6.7641    3.7469    0.9304    3.5570    0.1960    0.2308    5.7616    1.4554
-#> 444:    93.0905   -5.9504   -2.0785   -4.2972   -0.9462    0.1467    6.7570    3.7486    0.9312    3.5601    0.1960    0.2311    5.7604    1.4553
-#> 445:    93.0903   -5.9515   -2.0782   -4.2977   -0.9462    0.1462    6.7547    3.7543    0.9319    3.5635    0.1960    0.2314    5.7595    1.4550
-#> 446:    93.0902   -5.9530   -2.0778   -4.2982   -0.9462    0.1459    6.7562    3.7615    0.9325    3.5664    0.1960    0.2316    5.7580    1.4548
-#> 447:    93.0905   -5.9541   -2.0775   -4.2990   -0.9463    0.1455    6.7639    3.7668    0.9333    3.5719    0.1960    0.2318    5.7574    1.4543
-#> 448:    93.0912   -5.9555   -2.0772   -4.2999   -0.9463    0.1452    6.7671    3.7736    0.9340    3.5783    0.1960    0.2322    5.7572    1.4540
-#> 449:    93.0918   -5.9570   -2.0769   -4.3004   -0.9464    0.1448    6.7824    3.7802    0.9345    3.5809    0.1960    0.2326    5.7561    1.4537
-#> 450:    93.0901   -5.9579   -2.0766   -4.3011   -0.9464    0.1444    6.7866    3.7829    0.9351    3.5853    0.1959    0.2329    5.7551    1.4536
-#> 451:    93.0899   -5.9594   -2.0763   -4.3016   -0.9465    0.1439    6.7875    3.7896    0.9356    3.5888    0.1959    0.2332    5.7550    1.4537
-#> 452:    93.0902   -5.9603   -2.0759   -4.3023   -0.9465    0.1435    6.7953    3.7926    0.9363    3.5927    0.1958    0.2335    5.7537    1.4538
-#> 453:    93.0906   -5.9615   -2.0755   -4.3026   -0.9465    0.1430    6.7996    3.7982    0.9372    3.5950    0.1958    0.2338    5.7531    1.4539
-#> 454:    93.0909   -5.9614   -2.0751   -4.3029   -0.9465    0.1425    6.8016    3.7969    0.9381    3.5976    0.1958    0.2340    5.7532    1.4540
-#> 455:    93.0909   -5.9610   -2.0749   -4.3035   -0.9464    0.1420    6.8022    3.7940    0.9391    3.6022    0.1957    0.2342    5.7532    1.4539
-#> 456:    93.0916   -5.9600   -2.0746   -4.3045   -0.9463    0.1416    6.7942    3.7893    0.9398    3.6104    0.1957    0.2344    5.7540    1.4537
-#> 457:    93.0905   -5.9595   -2.0744   -4.3058   -0.9463    0.1411    6.7931    3.7866    0.9407    3.6210    0.1956    0.2345    5.7551    1.4534
-#> 458:    93.0905   -5.9597   -2.0742   -4.3071   -0.9462    0.1407    6.7877    3.7882    0.9416    3.6327    0.1955    0.2347    5.7566    1.4532
-#> 459:    93.0895   -5.9598   -2.0741   -4.3078   -0.9461    0.1402    6.7884    3.7889    0.9425    3.6383    0.1955    0.2349    5.7601    1.4527
-#> 460:    93.0871   -5.9602   -2.0741   -4.3086   -0.9460    0.1398    6.7889    3.7912    0.9434    3.6439    0.1954    0.2350    5.7619    1.4522
-#> 461:    93.0854   -5.9613   -2.0739   -4.3091   -0.9459    0.1393    6.7813    3.7973    0.9440    3.6481    0.1953    0.2351    5.7620    1.4520
-#> 462:    93.0838   -5.9623   -2.0737   -4.3093   -0.9458    0.1388    6.7791    3.8037    0.9445    3.6498    0.1953    0.2353    5.7616    1.4518
-#> 463:    93.0816   -5.9629   -2.0734   -4.3095   -0.9457    0.1384    6.7733    3.8070    0.9451    3.6508    0.1952    0.2355    5.7626    1.4519
-#> 464:    93.0792   -5.9631   -2.0731   -4.3095   -0.9457    0.1379    6.7697    3.8081    0.9460    3.6507    0.1951    0.2358    5.7638    1.4518
-#> 465:    93.0775   -5.9633   -2.0728   -4.3095   -0.9456    0.1374    6.7717    3.8095    0.9466    3.6506    0.1950    0.2361    5.7647    1.4519
-#> 466:    93.0774   -5.9640   -2.0725   -4.3097   -0.9455    0.1368    6.7686    3.8141    0.9473    3.6516    0.1949    0.2363    5.7662    1.4516
-#> 467:    93.0773   -5.9646   -2.0722   -4.3100   -0.9454    0.1364    6.7668    3.8172    0.9480    3.6535    0.1948    0.2366    5.7671    1.4516
-#> 468:    93.0777   -5.9653   -2.0719   -4.3106   -0.9453    0.1358    6.7648    3.8226    0.9487    3.6566    0.1947    0.2371    5.7681    1.4514
-#> 469:    93.0778   -5.9657   -2.0717   -4.3112   -0.9453    0.1353    6.7617    3.8253    0.9495    3.6588    0.1947    0.2375    5.7686    1.4510
-#> 470:    93.0769   -5.9663   -2.0715   -4.3117   -0.9452    0.1347    6.7650    3.8278    0.9503    3.6613    0.1947    0.2379    5.7688    1.4506
-#> 471:    93.0749   -5.9664   -2.0714   -4.3123   -0.9451    0.1342    6.7708    3.8280    0.9510    3.6643    0.1947    0.2383    5.7699    1.4505
-#> 472:    93.0721   -5.9668   -2.0713   -4.3127   -0.9450    0.1337    6.7756    3.8284    0.9517    3.6665    0.1947    0.2386    5.7710    1.4501
-#> 473:    93.0696   -5.9670   -2.0713   -4.3133   -0.9449    0.1333    6.7784    3.8280    0.9522    3.6698    0.1947    0.2388    5.7716    1.4498
-#> 474:    93.0674   -5.9673   -2.0714   -4.3138   -0.9448    0.1329    6.7761    3.8281    0.9527    3.6731    0.1947    0.2390    5.7729    1.4496
-#> 475:    93.0655   -5.9679   -2.0714   -4.3143   -0.9447    0.1324    6.7779    3.8302    0.9531    3.6762    0.1947    0.2391    5.7743    1.4493
-#> 476:    93.0643   -5.9682   -2.0713   -4.3144   -0.9447    0.1321    6.7776    3.8314    0.9536    3.6768    0.1946    0.2391    5.7762    1.4492
-#> 477:    93.0631   -5.9684   -2.0714   -4.3146   -0.9446    0.1317    6.7725    3.8326    0.9540    3.6787    0.1945    0.2392    5.7768    1.4492
-#> 478:    93.0630   -5.9693   -2.0715   -4.3148   -0.9447    0.1314    6.7626    3.8365    0.9543    3.6788    0.1944    0.2395    5.7785    1.4492
-#> 479:    93.0634   -5.9710   -2.0714   -4.3148   -0.9447    0.1310    6.7499    3.8462    0.9547    3.6778    0.1943    0.2399    5.7798    1.4490
-#> 480:    93.0651   -5.9732   -2.0715   -4.3147   -0.9447    0.1307    6.7463    3.8616    0.9548    3.6770    0.1943    0.2403    5.7810    1.4488
-#> 481:    93.0664   -5.9747   -2.0715   -4.3149   -0.9447    0.1304    6.7442    3.8722    0.9550    3.6780    0.1941    0.2409    5.7811    1.4487
-#> 482:    93.0647   -5.9762   -2.0714   -4.3151   -0.9447    0.1300    6.7389    3.8834    0.9554    3.6784    0.1941    0.2414    5.7816    1.4484
-#> 483:    93.0628   -5.9778   -2.0714   -4.3153   -0.9447    0.1295    6.7352    3.8943    0.9557    3.6783    0.1940    0.2419    5.7820    1.4483
-#> 484:    93.0614   -5.9787   -2.0715   -4.3153   -0.9447    0.1291    6.7314    3.8999    0.9559    3.6774    0.1939    0.2424    5.7819    1.4481
-#> 485:    93.0593   -5.9789   -2.0715   -4.3153   -0.9447    0.1288    6.7293    3.9007    0.9561    3.6765    0.1938    0.2430    5.7815    1.4480
-#> 486:    93.0575   -5.9793   -2.0716   -4.3152   -0.9447    0.1284    6.7331    3.9021    0.9563    3.6753    0.1938    0.2434    5.7806    1.4480
-#> 487:    93.0555   -5.9796   -2.0716   -4.3152   -0.9447    0.1281    6.7342    3.9036    0.9566    3.6741    0.1937    0.2439    5.7805    1.4479
-#> 488:    93.0545   -5.9795   -2.0716   -4.3152   -0.9447    0.1277    6.7365    3.9024    0.9569    3.6729    0.1937    0.2444    5.7795    1.4480
-#> 489:    93.0550   -5.9800   -2.0716   -4.3152   -0.9447    0.1274    6.7336    3.9046    0.9571    3.6719    0.1937    0.2448    5.7778    1.4481
-#> 490:    93.0571   -5.9793   -2.0715   -4.3152   -0.9447    0.1272    6.7331    3.9009    0.9573    3.6704    0.1936    0.2450    5.7767    1.4484
-#> 491:    93.0584   -5.9787   -2.0714   -4.3151   -0.9447    0.1270    6.7280    3.8980    0.9575    3.6688    0.1936    0.2452    5.7764    1.4487
-#> 492:    93.0589   -5.9786   -2.0714   -4.3150   -0.9447    0.1267    6.7264    3.8971    0.9578    3.6675    0.1936    0.2455    5.7759    1.4489
-#> 493:    93.0593   -5.9790   -2.0711   -4.3149   -0.9447    0.1265    6.7273    3.8982    0.9584    3.6660    0.1935    0.2456    5.7759    1.4490
-#> 494:    93.0594   -5.9805   -2.0710   -4.3149   -0.9448    0.1263    6.7291    3.9066    0.9590    3.6650    0.1935    0.2457    5.7758    1.4489
-#> 495:    93.0596   -5.9816   -2.0709   -4.3148   -0.9448    0.1261    6.7281    3.9123    0.9593    3.6639    0.1936    0.2459    5.7745    1.4490
-#> 496:    93.0590   -5.9829   -2.0707   -4.3148   -0.9448    0.1259    6.7319    3.9227    0.9597    3.6628    0.1936    0.2461    5.7740    1.4491
-#> 497:    93.0580   -5.9842   -2.0706   -4.3148   -0.9448    0.1257    6.7388    3.9326    0.9600    3.6623    0.1936    0.2463    5.7732    1.4492
-#> 498:    93.0578   -5.9848   -2.0705   -4.3148   -0.9448    0.1255    6.7447    3.9368    0.9605    3.6618    0.1936    0.2464    5.7726    1.4494
-#> 499:    93.0568   -5.9843   -2.0704   -4.3147   -0.9447    0.1253    6.7475    3.9341    0.9609    3.6612    0.1937    0.2467    5.7718    1.4495
-#> 500:    93.0563   -5.9831   -2.0703   -4.3147   -0.9447    0.1251    6.7500    3.9292    0.9614    3.6607    0.1937    0.2469    5.7712    1.4496
-#> Calculating covariance matrix
-#> 
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Calculating residuals/tables
-#> done
-f_nlmixr_dfop_sfo_focei_obs <- nlmixr(f_mmkin_obs["DFOP-SFO", ], est = "focei")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
-#> F: Forward difference gradient approximation
-#> C: Central difference gradient approximation
-#> M: Mixed forward and central difference gradient approximation
-#> Unscaled parameters for Omegas=chol(solve(omega));
-#> Diagonals are transformed, as specified by foceiControl(diagXform=)
-#> |-----+---------------+-----------+-----------+-----------+-----------|
-#> |    #| Objective Fun |  parent_0 |  log_k_A1 |f_parent_qlogis |    log_k1 |
-#> |.....................|    log_k2 |  g_qlogis |sigma_parent |  sigma_A1 |
-#> |.....................|        o1 |        o2 |        o3 |        o4 |
-#> |.....................|        o5 |        o6 |...........|...........|
-#> |    1|     488.98943 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     488.98943 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     488.98943 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    G|    Gill Diff. |    -27.68 |     2.403 |   -0.1248 |   -0.3242 |
-#> |.....................|   -0.3705 |   0.07384 |    -31.92 |    -15.13 |
-#> |.....................|     14.74 |     13.03 |    -12.01 |    -2.072 |
-#> |.....................|     5.553 |    -10.09 |...........|...........|
-#> |    2|     1205.4696 |     1.534 |    -1.046 |   -0.9091 |   -0.9266 |
-#> |.....................|   -0.9745 |   -0.8897 |   -0.2358 |   -0.5780 |
-#> |.....................|    -1.162 |    -1.126 |   -0.6367 |   -0.8323 |
-#> |.....................|   -0.9817 |   -0.6738 |...........|...........|
-#> |    U|     1205.4696 |     142.6 |    -5.346 |   -0.9477 |    -1.994 |
-#> |.....................|    -4.393 |    0.1897 |     2.616 |     1.260 |
-#> |.....................|    0.5160 |    0.6557 |     1.444 |     1.015 |
-#> |.....................|    0.7709 |     1.387 |...........|...........|
-#> |    X|     1205.4696 |     142.6 |  0.004766 |    0.2793 |    0.1362 |
-#> |.....................|   0.01237 |    0.5473 |     2.616 |     1.260 |
-#> |.....................|    0.5160 |    0.6557 |     1.444 |     1.015 |
-#> |.....................|    0.7709 |     1.387 |...........|...........|
-#> |    3|     510.70816 |     1.053 |    -1.005 |   -0.9113 |   -0.9322 |
-#> |.....................|   -0.9810 |   -0.8884 |   -0.7899 |   -0.8406 |
-#> |.....................|   -0.9059 |   -0.8995 |   -0.8452 |   -0.8683 |
-#> |.....................|   -0.8853 |   -0.8491 |...........|...........|
-#> |    U|     510.70816 |     97.96 |    -5.305 |   -0.9498 |    -1.999 |
-#> |.....................|    -4.399 |    0.1900 |     2.062 |     1.116 |
-#> |.....................|    0.7005 |    0.8538 |     1.199 |    0.9804 |
-#> |.....................|    0.8541 |     1.184 |...........|...........|
-#> |    X|     510.70816 |     97.96 |  0.004969 |    0.2789 |    0.1354 |
-#> |.....................|   0.01229 |    0.5474 |     2.062 |     1.116 |
-#> |.....................|    0.7005 |    0.8538 |     1.199 |    0.9804 |
-#> |.....................|    0.8541 |     1.184 |...........|...........|
-#> |    4|     494.11470 |     1.005 |    -1.000 |   -0.9115 |   -0.9328 |
-#> |.....................|   -0.9816 |   -0.8883 |   -0.8453 |   -0.8669 |
-#> |.....................|   -0.8803 |   -0.8769 |   -0.8660 |   -0.8719 |
-#> |.....................|   -0.8757 |   -0.8666 |...........|...........|
-#> |    U|      494.1147 |     93.50 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.006 |     1.102 |
-#> |.....................|    0.7190 |    0.8736 |     1.175 |    0.9768 |
-#> |.....................|    0.8624 |     1.163 |...........|...........|
-#> |    X|      494.1147 |     93.50 |  0.004989 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.006 |     1.102 |
-#> |.....................|    0.7190 |    0.8736 |     1.175 |    0.9768 |
-#> |.....................|    0.8624 |     1.163 |...........|...........|
-#> |    5|     494.35784 |     1.001 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8509 |   -0.8695 |
-#> |.....................|   -0.8778 |   -0.8746 |   -0.8681 |   -0.8723 |
-#> |.....................|   -0.8747 |   -0.8683 |...........|...........|
-#> |    U|     494.35784 |     93.05 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.001 |     1.100 |
-#> |.....................|    0.7208 |    0.8755 |     1.172 |    0.9765 |
-#> |.....................|    0.8632 |     1.161 |...........|...........|
-#> |    X|     494.35784 |     93.05 |  0.004991 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.001 |     1.100 |
-#> |.....................|    0.7208 |    0.8755 |     1.172 |    0.9765 |
-#> |.....................|    0.8632 |     1.161 |...........|...........|
-#> |    6|     494.40319 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8514 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8744 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40319 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8757 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40319 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8757 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    7|     494.40793 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8744 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40793 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40793 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    8|     494.40830 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|      494.4083 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|      494.4083 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    9|     494.40832 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40832 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40832 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |   10|     494.40832 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40832 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40832 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |   11|     494.40832 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40832 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40832 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |   12|     494.40832 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40832 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40832 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |   13|     494.40832 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40832 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40832 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |   14|     494.40832 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40832 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40832 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |   15|     494.40832 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40832 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40832 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |   16|     494.40832 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40832 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40832 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |   17|     494.40832 |     1.000 |    -1.000 |   -0.9115 |   -0.9329 |
-#> |.....................|   -0.9817 |   -0.8883 |   -0.8515 |   -0.8698 |
-#> |.....................|   -0.8775 |   -0.8743 |   -0.8683 |   -0.8723 |
-#> |.....................|   -0.8746 |   -0.8685 |...........|...........|
-#> |    U|     494.40832 |     93.00 |    -5.300 |   -0.9500 |    -2.000 |
-#> |.....................|    -4.400 |    0.1900 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> |    X|     494.40832 |     93.00 |  0.004992 |    0.2789 |    0.1353 |
-#> |.....................|   0.01228 |    0.5474 |     2.000 |     1.100 |
-#> |.....................|    0.7210 |    0.8758 |     1.172 |    0.9765 |
-#> |.....................|    0.8633 |     1.161 |...........|...........|
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-
-# Identical two-component error for all variables is only possible with
-# est = 'focei' in nlmixr
-f_nlmixr_fomc_sfo_focei_tc <- nlmixr(f_mmkin_tc["FOMC-SFO", ], est = "focei")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
-#> F: Forward difference gradient approximation
-#> C: Central difference gradient approximation
-#> M: Mixed forward and central difference gradient approximation
-#> Unscaled parameters for Omegas=chol(solve(omega));
-#> Diagonals are transformed, as specified by foceiControl(diagXform=)
-#> |-----+---------------+-----------+-----------+-----------+-----------|
-#> |    #| Objective Fun |  parent_0 |  log_k_A1 |f_parent_qlogis | log_alpha |
-#> |.....................|  log_beta | sigma_low |  rsd_high |        o1 |
-#> |.....................|        o2 |        o3 |        o4 |        o5 |
-#> |    1|     500.20030 |     1.000 |    -1.000 |   -0.9113 |   -0.8944 |
-#> |.....................|   -0.8454 |   -0.8678 |   -0.8916 |   -0.8767 |
-#> |.....................|   -0.8743 |   -0.8675 |   -0.8704 |   -0.8704 |
-#> |    U|      500.2003 |     93.00 |    -5.300 |   -0.9400 |   -0.1100 |
-#> |.....................|     2.300 |     1.200 |   0.03000 |    0.7598 |
-#> |.....................|    0.8758 |     1.214 |     1.068 |     1.071 |
-#> |    X|      500.2003 |     93.00 |  0.004992 |    0.2809 |    0.8958 |
-#> |.....................|     9.974 |     1.200 |   0.03000 |    0.7598 |
-#> |.....................|    0.8758 |     1.214 |     1.068 |     1.071 |
-#> |    G|    Gill Diff. |     48.88 |     2.383 |    0.1231 |    0.1986 |
-#> |.....................|    0.1571 |    -64.31 |    -21.89 |    0.6250 |
-#> |.....................|     11.41 |    -12.48 |    -9.903 |    -10.91 |
-#> |    2|     2909.4393 |    0.4361 |    -1.027 |   -0.9127 |   -0.8967 |
-#> |.....................|   -0.8472 |   -0.1258 |   -0.6390 |   -0.8839 |
-#> |.....................|    -1.006 |   -0.7235 |   -0.7562 |   -0.7445 |
-#> |    U|     2909.4393 |     40.56 |    -5.327 |   -0.9413 |   -0.1123 |
-#> |.....................|     2.298 |     1.645 |   0.03379 |    0.7544 |
-#> |.....................|    0.7605 |     1.389 |     1.189 |     1.206 |
-#> |    X|     2909.4393 |     40.56 |  0.004856 |    0.2806 |    0.8938 |
-#> |.....................|     9.956 |     1.645 |   0.03379 |    0.7544 |
-#> |.....................|    0.7605 |     1.389 |     1.189 |     1.206 |
-#> |    3|     515.24373 |    0.9436 |    -1.003 |   -0.9114 |   -0.8946 |
-#> |.....................|   -0.8456 |   -0.7936 |   -0.8663 |   -0.8774 |
-#> |.....................|   -0.8875 |   -0.8531 |   -0.8590 |   -0.8578 |
-#> |    U|     515.24373 |     87.76 |    -5.303 |   -0.9401 |   -0.1102 |
-#> |.....................|     2.300 |     1.245 |   0.03038 |    0.7593 |
-#> |.....................|    0.8642 |     1.232 |     1.080 |     1.084 |
-#> |    X|     515.24373 |     87.76 |  0.004978 |    0.2809 |    0.8956 |
-#> |.....................|     9.972 |     1.245 |   0.03038 |    0.7593 |
-#> |.....................|    0.8642 |     1.232 |     1.080 |     1.084 |
-#> |    4|     499.40695 |    0.9897 |    -1.001 |   -0.9113 |   -0.8944 |
-#> |.....................|   -0.8454 |   -0.8542 |   -0.8869 |   -0.8768 |
-#> |.....................|   -0.8768 |   -0.8648 |   -0.8684 |   -0.8681 |
-#> |    U|     499.40695 |     92.04 |    -5.301 |   -0.9400 |   -0.1100 |
-#> |.....................|     2.300 |     1.208 |   0.03007 |    0.7597 |
-#> |.....................|    0.8737 |     1.217 |     1.070 |     1.073 |
-#> |    X|     499.40695 |     92.04 |  0.004989 |    0.2809 |    0.8958 |
-#> |.....................|     9.974 |     1.208 |   0.03007 |    0.7597 |
-#> |.....................|    0.8737 |     1.217 |     1.070 |     1.073 |
-#> |    F| Forward Diff. |    -99.71 |     2.245 |   -0.1707 |    0.1202 |
-#> |.....................|   -0.1546 |    -61.69 |    -22.54 |     1.475 |
-#> |.....................|     7.677 |    -11.72 |    -9.584 |    -10.53 |
-#> |    5|     498.17135 |     1.001 |    -1.001 |   -0.9113 |   -0.8945 |
-#> |.....................|   -0.8454 |   -0.8410 |   -0.8822 |   -0.8771 |
-#> |.....................|   -0.8786 |   -0.8623 |   -0.8663 |   -0.8658 |
-#> |    U|     498.17135 |     93.06 |    -5.301 |   -0.9400 |   -0.1101 |
-#> |.....................|     2.300 |     1.216 |   0.03014 |    0.7595 |
-#> |.....................|    0.8720 |     1.221 |     1.072 |     1.076 |
-#> |    X|     498.17135 |     93.06 |  0.004987 |    0.2809 |    0.8958 |
-#> |.....................|     9.974 |     1.216 |   0.03014 |    0.7595 |
-#> |.....................|    0.8720 |     1.221 |     1.072 |     1.076 |
-#> |    F| Forward Diff. |     55.25 |     2.349 |    0.1359 |    0.2180 |
-#> |.....................|    0.1993 |    -60.48 |    -20.28 |     1.106 |
-#> |.....................|     9.662 |    -11.74 |    -9.501 |    -10.55 |
-#> |    6|     497.33758 |    0.9906 |    -1.002 |   -0.9113 |   -0.8945 |
-#> |.....................|   -0.8454 |   -0.8273 |   -0.8776 |   -0.8773 |
-#> |.....................|   -0.8808 |   -0.8596 |   -0.8642 |   -0.8634 |
-#> |    U|     497.33758 |     92.12 |    -5.302 |   -0.9400 |   -0.1101 |
-#> |.....................|     2.300 |     1.224 |   0.03021 |    0.7594 |
-#> |.....................|    0.8701 |     1.224 |     1.074 |     1.078 |
-#> |    X|     497.33758 |     92.12 |  0.004984 |    0.2809 |    0.8957 |
-#> |.....................|     9.974 |     1.224 |   0.03021 |    0.7594 |
-#> |.....................|    0.8701 |     1.224 |     1.074 |     1.078 |
-#> |    F| Forward Diff. |    -88.13 |     2.220 |   -0.1371 |    0.1382 |
-#> |.....................|   -0.1101 |    -57.44 |    -20.90 |     1.111 |
-#> |.....................|     7.358 |    -11.52 |    -9.371 |    -10.34 |
-#> |    7|     496.20963 |     1.001 |    -1.002 |   -0.9113 |   -0.8946 |
-#> |.....................|   -0.8454 |   -0.8137 |   -0.8728 |   -0.8776 |
-#> |.....................|   -0.8827 |   -0.8569 |   -0.8620 |   -0.8610 |
-#> |    U|     496.20963 |     93.07 |    -5.302 |   -0.9400 |   -0.1102 |
-#> |.....................|     2.300 |     1.232 |   0.03028 |    0.7592 |
-#> |.....................|    0.8684 |     1.227 |     1.077 |     1.081 |
-#> |    X|     496.20963 |     93.07 |  0.004981 |    0.2809 |    0.8957 |
-#> |.....................|     9.974 |     1.232 |   0.03028 |    0.7592 |
-#> |.....................|    0.8684 |     1.227 |     1.077 |     1.081 |
-#> |    F| Forward Diff. |     55.31 |     2.316 |    0.1573 |    0.2363 |
-#> |.....................|    0.2327 |    -56.27 |    -18.79 |    0.9054 |
-#> |.....................|     9.277 |    -11.53 |    -9.283 |    -10.35 |
-#> |    8|     495.35926 |    0.9914 |    -1.003 |   -0.9113 |   -0.8946 |
-#> |.....................|   -0.8455 |   -0.7996 |   -0.8680 |   -0.8778 |
-#> |.....................|   -0.8850 |   -0.8541 |   -0.8597 |   -0.8584 |
-#> |    U|     495.35926 |     92.20 |    -5.303 |   -0.9401 |   -0.1102 |
-#> |.....................|     2.300 |     1.241 |   0.03035 |    0.7590 |
-#> |.....................|    0.8664 |     1.231 |     1.079 |     1.084 |
-#> |    X|     495.35926 |     92.20 |  0.004979 |    0.2809 |    0.8956 |
-#> |.....................|     9.973 |     1.241 |   0.03035 |    0.7590 |
-#> |.....................|    0.8664 |     1.231 |     1.079 |     1.084 |
-#> |    F| Forward Diff. |    -77.78 |     2.194 |   -0.1077 |    0.1552 |
-#> |.....................|  -0.06714 |    -52.97 |    -19.27 |    0.8916 |
-#> |.....................|     7.037 |    -11.29 |    -9.130 |    -10.15 |
-#> |    9|     494.33654 |     1.001 |    -1.003 |   -0.9113 |   -0.8947 |
-#> |.....................|   -0.8455 |   -0.7857 |   -0.8631 |   -0.8780 |
-#> |.....................|   -0.8870 |   -0.8511 |   -0.8573 |   -0.8558 |
-#> |    U|     494.33654 |     93.09 |    -5.303 |   -0.9400 |   -0.1103 |
-#> |.....................|     2.300 |     1.249 |   0.03043 |    0.7588 |
-#> |.....................|    0.8647 |     1.234 |     1.082 |     1.087 |
-#> |    X|     494.33654 |     93.09 |  0.004976 |    0.2809 |    0.8956 |
-#> |.....................|     9.973 |     1.249 |   0.03043 |    0.7588 |
-#> |.....................|    0.8647 |     1.234 |     1.082 |     1.087 |
-#> |    F| Forward Diff. |     55.95 |     2.282 |    0.1850 |    0.2507 |
-#> |.....................|    0.2656 |    -51.81 |    -17.28 |    0.8212 |
-#> |.....................|     7.543 |    -11.27 |    -9.029 |    -10.13 |
-#> |   10|     493.47922 |    0.9922 |    -1.004 |   -0.9114 |   -0.8947 |
-#> |.....................|   -0.8455 |   -0.7714 |   -0.8582 |   -0.8782 |
-#> |.....................|   -0.8891 |   -0.8480 |   -0.8548 |   -0.8530 |
-#> |    U|     493.47922 |     92.28 |    -5.304 |   -0.9401 |   -0.1103 |
-#> |.....................|     2.300 |     1.258 |   0.03050 |    0.7587 |
-#> |.....................|    0.8629 |     1.238 |     1.084 |     1.090 |
-#> |    X|     493.47922 |     92.28 |  0.004973 |    0.2809 |    0.8955 |
-#> |.....................|     9.973 |     1.258 |   0.03050 |    0.7587 |
-#> |.....................|    0.8629 |     1.238 |     1.084 |     1.090 |
-#> |    F| Forward Diff. |    -67.18 |     2.173 |  -0.07166 |    0.1818 |
-#> |.....................|  -0.01313 |    -49.19 |    -17.69 |    0.7047 |
-#> |.....................|     8.114 |    -11.03 |    -8.882 |    -9.923 |
-#> |   11|     492.53845 |     1.001 |    -1.004 |   -0.9114 |   -0.8948 |
-#> |.....................|   -0.8456 |   -0.7572 |   -0.8532 |   -0.8784 |
-#> |.....................|   -0.8914 |   -0.8448 |   -0.8522 |   -0.8501 |
-#> |    U|     492.53845 |     93.09 |    -5.304 |   -0.9401 |   -0.1104 |
-#> |.....................|     2.300 |     1.266 |   0.03057 |    0.7585 |
-#> |.....................|    0.8608 |     1.242 |     1.087 |     1.093 |
-#> |    X|     492.53845 |     93.09 |  0.004969 |    0.2809 |    0.8955 |
-#> |.....................|     9.972 |     1.266 |   0.03057 |    0.7585 |
-#> |.....................|    0.8608 |     1.242 |     1.087 |     1.093 |
-#> |    F| Forward Diff. |     53.38 |     2.243 |    0.1941 |    0.2566 |
-#> |.....................|    0.2879 |    -47.96 |    -15.83 |    0.7595 |
-#> |.....................|     8.537 |    -10.98 |    -8.771 |    -9.890 |
-#> |   12|     491.72645 |    0.9926 |    -1.005 |   -0.9114 |   -0.8949 |
-#> |.....................|   -0.8456 |   -0.7429 |   -0.8484 |   -0.8786 |
-#> |.....................|   -0.8941 |   -0.8415 |   -0.8496 |   -0.8471 |
-#> |    U|     491.72645 |     92.31 |    -5.305 |   -0.9401 |   -0.1105 |
-#> |.....................|     2.300 |     1.275 |   0.03065 |    0.7584 |
-#> |.....................|    0.8584 |     1.246 |     1.090 |     1.096 |
-#> |    X|     491.72645 |     92.31 |  0.004966 |    0.2809 |    0.8954 |
-#> |.....................|     9.972 |     1.275 |   0.03065 |    0.7584 |
-#> |.....................|    0.8584 |     1.246 |     1.090 |     1.096 |
-#> |    F| Forward Diff. |    -63.56 |     2.131 |  -0.05387 |    0.1833 |
-#> |.....................| 0.0009134 |    -45.55 |    -16.30 |    0.3872 |
-#> |.....................|     9.447 |    -10.76 |    -8.612 |    -9.684 |
-#> |   13|     490.83850 |     1.001 |    -1.006 |   -0.9114 |   -0.8949 |
-#> |.....................|   -0.8457 |   -0.7286 |   -0.8435 |   -0.8787 |
-#> |.....................|   -0.8974 |   -0.8380 |   -0.8468 |   -0.8440 |
-#> |    U|      490.8385 |     93.07 |    -5.306 |   -0.9401 |   -0.1105 |
-#> |.....................|     2.300 |     1.283 |   0.03072 |    0.7583 |
-#> |.....................|    0.8556 |     1.250 |     1.093 |     1.099 |
-#> |    X|      490.8385 |     93.07 |  0.004963 |    0.2809 |    0.8954 |
-#> |.....................|     9.971 |     1.283 |   0.03072 |    0.7583 |
-#> |.....................|    0.8556 |     1.250 |     1.093 |     1.099 |
-#> |    F| Forward Diff. |     49.01 |     2.198 |    0.2057 |    0.2666 |
-#> |.....................|    0.3102 |    -44.06 |    -14.52 |    0.5614 |
-#> |.....................|     8.039 |    -10.72 |    -8.482 |    -9.628 |
-#> |   14|     490.09324 |    0.9928 |    -1.007 |   -0.9115 |   -0.8950 |
-#> |.....................|   -0.8458 |   -0.7143 |   -0.8387 |   -0.8788 |
-#> |.....................|   -0.9004 |   -0.8343 |   -0.8439 |   -0.8407 |
-#> |    U|     490.09324 |     92.33 |    -5.307 |   -0.9402 |   -0.1106 |
-#> |.....................|     2.300 |     1.292 |   0.03079 |    0.7582 |
-#> |.....................|    0.8529 |     1.254 |     1.096 |     1.103 |
-#> |    X|     490.09324 |     92.33 |  0.004959 |    0.2809 |    0.8953 |
-#> |.....................|     9.970 |     1.292 |   0.03079 |    0.7582 |
-#> |.....................|    0.8529 |     1.254 |     1.096 |     1.103 |
-#> |    F| Forward Diff. |    -62.13 |     2.095 |  -0.03472 |    0.1999 |
-#> |.....................|   0.03562 |    -41.55 |    -14.84 |    0.5236 |
-#> |.....................|     7.264 |    -10.46 |    -8.310 |    -9.412 |
-#> |   15|     489.25271 |     1.001 |    -1.007 |   -0.9115 |   -0.8951 |
-#> |.....................|   -0.8458 |   -0.7001 |   -0.8338 |   -0.8789 |
-#> |.....................|   -0.9032 |   -0.8304 |   -0.8408 |   -0.8372 |
-#> |    U|     489.25271 |     93.06 |    -5.307 |   -0.9402 |   -0.1107 |
-#> |.....................|     2.300 |     1.301 |   0.03087 |    0.7581 |
-#> |.....................|    0.8505 |     1.259 |     1.099 |     1.107 |
-#> |    X|     489.25271 |     93.06 |  0.004955 |    0.2809 |    0.8952 |
-#> |.....................|     9.970 |     1.301 |   0.03087 |    0.7581 |
-#> |.....................|    0.8505 |     1.259 |     1.099 |     1.107 |
-#> |    F| Forward Diff. |     44.98 |     2.155 |    0.2191 |    0.2769 |
-#> |.....................|    0.3339 |    -40.42 |    -13.24 |    0.4473 |
-#> |.....................|     7.595 |    -10.35 |    -8.165 |    -9.335 |
-#> |   16|     488.54089 |    0.9934 |    -1.008 |   -0.9116 |   -0.8952 |
-#> |.....................|   -0.8459 |   -0.6857 |   -0.8290 |   -0.8790 |
-#> |.....................|   -0.9061 |   -0.8262 |   -0.8376 |   -0.8335 |
-#> |    U|     488.54089 |     92.38 |    -5.308 |   -0.9403 |   -0.1108 |
-#> |.....................|     2.299 |     1.309 |   0.03094 |    0.7581 |
-#> |.....................|    0.8479 |     1.264 |     1.103 |     1.111 |
-#> |    X|     488.54089 |     92.38 |  0.004951 |    0.2808 |    0.8951 |
-#> |.....................|     9.968 |     1.309 |   0.03094 |    0.7581 |
-#> |.....................|    0.8479 |     1.264 |     1.103 |     1.111 |
-#> |    F| Forward Diff. |    -55.81 |     2.061 |  -0.02096 |    0.2050 |
-#> |.....................|   0.07367 |    -38.08 |    -13.50 |    0.4111 |
-#> |.....................|     6.904 |    -10.08 |    -7.981 |    -9.106 |
-#> |   17|     487.77387 |     1.001 |    -1.009 |   -0.9116 |   -0.8953 |
-#> |.....................|   -0.8461 |   -0.6716 |   -0.8243 |   -0.8791 |
-#> |.....................|   -0.9092 |   -0.8218 |   -0.8341 |   -0.8294 |
-#> |    U|     487.77387 |     93.07 |    -5.309 |   -0.9403 |   -0.1109 |
-#> |.....................|     2.299 |     1.318 |   0.03101 |    0.7580 |
-#> |.....................|    0.8453 |     1.270 |     1.106 |     1.115 |
-#> |    X|     487.77387 |     93.07 |  0.004946 |    0.2808 |    0.8950 |
-#> |.....................|     9.967 |     1.318 |   0.03101 |    0.7580 |
-#> |.....................|    0.8453 |     1.270 |     1.106 |     1.115 |
-#> |    F| Forward Diff. |     43.45 |     2.114 |    0.2402 |    0.2940 |
-#> |.....................|    0.3672 |    -36.87 |    -12.03 |    0.3081 |
-#> |.....................|     7.143 |    -10.02 |    -7.799 |    -9.000 |
-#> |   18|     487.09815 |    0.9939 |    -1.010 |   -0.9118 |   -0.8955 |
-#> |.....................|   -0.8463 |   -0.6575 |   -0.8197 |   -0.8791 |
-#> |.....................|   -0.9124 |   -0.8169 |   -0.8304 |   -0.8251 |
-#> |    U|     487.09815 |     92.43 |    -5.310 |   -0.9404 |   -0.1111 |
-#> |.....................|     2.299 |     1.326 |   0.03108 |    0.7580 |
-#> |.....................|    0.8425 |     1.276 |     1.110 |     1.120 |
-#> |    X|     487.09815 |     92.43 |  0.004941 |    0.2808 |    0.8948 |
-#> |.....................|     9.965 |     1.326 |   0.03108 |    0.7580 |
-#> |.....................|    0.8425 |     1.276 |     1.110 |     1.120 |
-#> |    F| Forward Diff. |    -50.03 |     2.024 |  0.005993 |    0.2193 |
-#> |.....................|    0.1119 |    -34.69 |    -12.26 |    0.2072 |
-#> |.....................|     6.453 |    -9.722 |    -7.597 |    -8.758 |
-#> |   19|     486.39882 |     1.001 |    -1.011 |   -0.9119 |   -0.8957 |
-#> |.....................|   -0.8465 |   -0.6438 |   -0.8151 |   -0.8789 |
-#> |.....................|   -0.9156 |   -0.8116 |   -0.8264 |   -0.8203 |
-#> |    U|     486.39882 |     93.07 |    -5.311 |   -0.9405 |   -0.1113 |
-#> |.....................|     2.299 |     1.334 |   0.03115 |    0.7582 |
-#> |.....................|    0.8396 |     1.282 |     1.114 |     1.125 |
-#> |    X|     486.39882 |     93.07 |  0.004935 |    0.2808 |    0.8947 |
-#> |.....................|     9.963 |     1.334 |   0.03115 |    0.7582 |
-#> |.....................|    0.8396 |     1.282 |     1.114 |     1.125 |
-#> |    F| Forward Diff. |     41.24 |     2.069 |    0.2581 |    0.3038 |
-#> |.....................|    0.3965 |    -33.71 |    -10.93 |    0.1523 |
-#> |.....................|     5.279 |    -9.597 |    -7.397 |    -8.617 |
-#> |   20|     485.77269 |    0.9943 |    -1.013 |   -0.9120 |   -0.8959 |
-#> |.....................|   -0.8467 |   -0.6301 |   -0.8107 |   -0.8786 |
-#> |.....................|   -0.9175 |   -0.8058 |   -0.8222 |   -0.8151 |
-#> |    U|     485.77269 |     92.47 |    -5.313 |   -0.9407 |   -0.1115 |
-#> |.....................|     2.299 |     1.343 |   0.03121 |    0.7584 |
-#> |.....................|    0.8380 |     1.289 |     1.119 |     1.130 |
-#> |    X|     485.77269 |     92.47 |  0.004928 |    0.2808 |    0.8945 |
-#> |.....................|     9.960 |     1.343 |   0.03121 |    0.7584 |
-#> |.....................|    0.8380 |     1.289 |     1.119 |     1.130 |
-#> |    F| Forward Diff. |    -45.38 |     1.992 |   0.03513 |    0.2356 |
-#> |.....................|    0.1513 |    -31.62 |    -11.12 |   0.08802 |
-#> |.....................|     6.113 |    -9.278 |    -7.167 |    -8.332 |
-#> |   21|     485.13787 |     1.001 |    -1.014 |   -0.9122 |   -0.8962 |
-#> |.....................|   -0.8471 |   -0.6169 |   -0.8065 |   -0.8780 |
-#> |.....................|   -0.9196 |   -0.7993 |   -0.8176 |   -0.8094 |
-#> |    U|     485.13787 |     93.06 |    -5.314 |   -0.9409 |   -0.1118 |
-#> |.....................|     2.298 |     1.351 |   0.03128 |    0.7588 |
-#> |.....................|    0.8361 |     1.297 |     1.124 |     1.136 |
-#> |    X|     485.13787 |     93.06 |  0.004921 |    0.2807 |    0.8942 |
-#> |.....................|     9.957 |     1.351 |   0.03128 |    0.7588 |
-#> |.....................|    0.8361 |     1.297 |     1.124 |     1.136 |
-#> |    F| Forward Diff. |     37.95 |     2.033 |    0.2726 |    0.3147 |
-#> |.....................|    0.4223 |    -30.68 |    -9.906 |   0.05100 |
-#> |.....................|     4.975 |    -9.039 |    -6.928 |    -8.144 |
-#> |   22|     484.56781 |    0.9947 |    -1.016 |   -0.9125 |   -0.8965 |
-#> |.....................|   -0.8476 |   -0.6040 |   -0.8026 |   -0.8774 |
-#> |.....................|   -0.9219 |   -0.7925 |   -0.8127 |   -0.8032 |
-#> |    U|     484.56781 |     92.51 |    -5.316 |   -0.9411 |   -0.1121 |
-#> |.....................|     2.298 |     1.358 |   0.03133 |    0.7593 |
-#> |.....................|    0.8341 |     1.305 |     1.129 |     1.143 |
-#> |    X|     484.56781 |     92.51 |  0.004912 |    0.2807 |    0.8939 |
-#> |.....................|     9.952 |     1.358 |   0.03133 |    0.7593 |
-#> |.....................|    0.8341 |     1.305 |     1.129 |     1.143 |
-#> |    F| Forward Diff. |    -42.28 |     1.959 |   0.05438 |    0.2483 |
-#> |.....................|    0.1829 |    -28.95 |    -10.12 |  -0.04344 |
-#> |.....................|     4.379 |    -8.677 |    -6.653 |    -7.817 |
-#> |   23|     484.00832 |     1.000 |    -1.018 |   -0.9128 |   -0.8970 |
-#> |.....................|   -0.8481 |   -0.5915 |   -0.7988 |   -0.8764 |
-#> |.....................|   -0.9214 |   -0.7852 |   -0.8076 |   -0.7966 |
-#> |    U|     484.00832 |     93.05 |    -5.318 |   -0.9414 |   -0.1125 |
-#> |.....................|     2.297 |     1.366 |   0.03139 |    0.7601 |
-#> |.....................|    0.8346 |     1.314 |     1.135 |     1.150 |
-#> |    X|     484.00832 |     93.05 |  0.004901 |    0.2806 |    0.8936 |
-#> |.....................|     9.947 |     1.366 |   0.03139 |    0.7601 |
-#> |.....................|    0.8346 |     1.314 |     1.135 |     1.150 |
-#> |    F| Forward Diff. |     34.54 |     2.001 |    0.2786 |    0.3182 |
-#> |.....................|    0.4381 |    -28.02 |    -9.026 |  -0.09975 |
-#> |.....................|     6.146 |    -8.496 |    -6.417 |    -7.602 |
-#> |   24|     483.48726 |    0.9952 |    -1.021 |   -0.9132 |   -0.8975 |
-#> |.....................|   -0.8489 |   -0.5798 |   -0.7955 |   -0.8750 |
-#> |.....................|   -0.9256 |   -0.7775 |   -0.8025 |   -0.7898 |
-#> |    U|     483.48726 |     92.55 |    -5.321 |   -0.9418 |   -0.1131 |
-#> |.....................|     2.296 |     1.373 |   0.03144 |    0.7611 |
-#> |.....................|    0.8309 |     1.323 |     1.140 |     1.157 |
-#> |    X|     483.48726 |     92.55 |  0.004889 |    0.2805 |    0.8931 |
-#> |.....................|     9.939 |     1.373 |   0.03144 |    0.7611 |
-#> |.....................|    0.8309 |     1.323 |     1.140 |     1.157 |
-#> |    F| Forward Diff. |    -37.52 |     1.926 |   0.07054 |    0.2526 |
-#> |.....................|    0.2102 |    -26.43 |    -9.184 |   -0.1123 |
-#> |.....................|     5.591 |    -8.057 |    -6.119 |    -7.239 |
-#> |   25|     482.99669 |     1.001 |    -1.023 |   -0.9136 |   -0.8980 |
-#> |.....................|   -0.8497 |   -0.5700 |   -0.7928 |   -0.8735 |
-#> |.....................|   -0.9342 |   -0.7702 |   -0.7978 |   -0.7834 |
-#> |    U|     482.99669 |     93.05 |    -5.323 |   -0.9422 |   -0.1136 |
-#> |.....................|     2.296 |     1.379 |   0.03148 |    0.7623 |
-#> |.....................|    0.8234 |     1.332 |     1.145 |     1.164 |
-#> |    X|     482.99669 |     93.05 |  0.004876 |    0.2805 |    0.8926 |
-#> |.....................|     9.932 |     1.379 |   0.03148 |    0.7623 |
-#> |.....................|    0.8234 |     1.332 |     1.145 |     1.164 |
-#> |    F| Forward Diff. |     33.56 |     1.934 |    0.3091 |    0.3219 |
-#> |.....................|    0.4700 |    -25.85 |    -8.255 |  -0.09267 |
-#> |.....................|     5.467 |    -7.833 |    -5.883 |    -7.031 |
-#> |   26|     482.53338 |    0.9957 |    -1.027 |   -0.9143 |   -0.8987 |
-#> |.....................|   -0.8507 |   -0.5600 |   -0.7904 |   -0.8719 |
-#> |.....................|   -0.9423 |   -0.7626 |   -0.7931 |   -0.7767 |
-#> |    U|     482.53338 |     92.60 |    -5.327 |   -0.9428 |   -0.1143 |
-#> |.....................|     2.295 |     1.385 |   0.03152 |    0.7635 |
-#> |.....................|    0.8163 |     1.342 |     1.150 |     1.171 |
-#> |    X|     482.53338 |     92.60 |  0.004861 |    0.2803 |    0.8920 |
-#> |.....................|     9.921 |     1.385 |   0.03152 |    0.7635 |
-#> |.....................|    0.8163 |     1.342 |     1.150 |     1.171 |
-#> |    F| Forward Diff. |    -33.71 |     1.852 |    0.1405 |    0.2615 |
-#> |.....................|    0.2476 |    -24.53 |    -8.462 |   -0.2274 |
-#> |.....................|     4.657 |    -7.455 |    -5.599 |    -6.689 |
-#> |   27|     482.07760 |     1.001 |    -1.030 |   -0.9154 |   -0.8996 |
-#> |.....................|   -0.8522 |   -0.5495 |   -0.7881 |   -0.8694 |
-#> |.....................|   -0.9481 |   -0.7546 |   -0.7885 |   -0.7696 |
-#> |    U|      482.0776 |     93.06 |    -5.330 |   -0.9439 |   -0.1152 |
-#> |.....................|     2.293 |     1.391 |   0.03155 |    0.7654 |
-#> |.....................|    0.8112 |     1.351 |     1.155 |     1.179 |
-#> |    X|      482.0776 |     93.06 |  0.004842 |    0.2801 |    0.8912 |
-#> |.....................|     9.906 |     1.391 |   0.03155 |    0.7654 |
-#> |.....................|    0.8112 |     1.351 |     1.155 |     1.179 |
-#> |    F| Forward Diff. |     31.51 |     1.862 |    0.3171 |    0.3253 |
-#> |.....................|    0.4890 |    -23.74 |    -7.570 |   -0.1627 |
-#> |.....................|     4.673 |    -7.176 |    -5.365 |    -6.441 |
-#> |   28|     481.65018 |    0.9960 |    -1.035 |   -0.9168 |   -0.9007 |
-#> |.....................|   -0.8541 |   -0.5386 |   -0.7859 |   -0.8662 |
-#> |.....................|   -0.9515 |   -0.7465 |   -0.7840 |   -0.7624 |
-#> |    U|     481.65018 |     92.63 |    -5.335 |   -0.9452 |   -0.1163 |
-#> |.....................|     2.291 |     1.398 |   0.03158 |    0.7678 |
-#> |.....................|    0.8082 |     1.361 |     1.160 |     1.187 |
-#> |    X|     481.65018 |     92.63 |  0.004820 |    0.2799 |    0.8902 |
-#> |.....................|     9.887 |     1.398 |   0.03158 |    0.7678 |
-#> |.....................|    0.8082 |     1.361 |     1.160 |     1.187 |
-#> |    F| Forward Diff. |    -31.18 |     1.794 |    0.1244 |    0.2518 |
-#> |.....................|    0.2479 |    -22.54 |    -7.736 |   -0.2537 |
-#> |.....................|     4.155 |    -6.794 |    -5.094 |    -6.088 |
-#> |   29|     481.23911 |     1.000 |    -1.041 |   -0.9182 |   -0.9020 |
-#> |.....................|   -0.8564 |   -0.5274 |   -0.7840 |   -0.8624 |
-#> |.....................|   -0.9539 |   -0.7386 |   -0.7800 |   -0.7556 |
-#> |    U|     481.23911 |     93.04 |    -5.341 |   -0.9465 |   -0.1176 |
-#> |.....................|     2.289 |     1.404 |   0.03161 |    0.7707 |
-#> |.....................|    0.8061 |     1.371 |     1.164 |     1.194 |
-#> |    X|     481.23911 |     93.04 |  0.004792 |    0.2796 |    0.8890 |
-#> |.....................|     9.865 |     1.404 |   0.03161 |    0.7707 |
-#> |.....................|    0.8061 |     1.371 |     1.164 |     1.194 |
-#> |   30|     480.84332 |     1.001 |    -1.048 |   -0.9201 |   -0.9037 |
-#> |.....................|   -0.8593 |   -0.5164 |   -0.7829 |   -0.8573 |
-#> |.....................|   -0.9562 |   -0.7293 |   -0.7754 |   -0.7475 |
-#> |    U|     480.84332 |     93.06 |    -5.348 |   -0.9483 |   -0.1193 |
-#> |.....................|     2.286 |     1.411 |   0.03163 |    0.7746 |
-#> |.....................|    0.8041 |     1.382 |     1.169 |     1.203 |
-#> |    X|     480.84332 |     93.06 |  0.004757 |    0.2792 |    0.8875 |
-#> |.....................|     9.836 |     1.411 |   0.03163 |    0.7746 |
-#> |.....................|    0.8041 |     1.382 |     1.169 |     1.203 |
-#> |   31|     479.47395 |     1.001 |    -1.077 |   -0.9274 |   -0.9105 |
-#> |.....................|   -0.8708 |   -0.4737 |   -0.7785 |   -0.8375 |
-#> |.....................|   -0.9655 |   -0.6927 |   -0.7575 |   -0.7158 |
-#> |    U|     479.47395 |     93.12 |    -5.377 |   -0.9551 |   -0.1261 |
-#> |.....................|     2.275 |     1.436 |   0.03170 |    0.7896 |
-#> |.....................|    0.7959 |     1.426 |     1.188 |     1.237 |
-#> |    X|     479.47395 |     93.12 |  0.004620 |    0.2779 |    0.8816 |
-#> |.....................|     9.723 |     1.436 |   0.03170 |    0.7896 |
-#> |.....................|    0.7959 |     1.426 |     1.188 |     1.237 |
-#> |   32|     477.01144 |     1.003 |    -1.162 |   -0.9485 |   -0.9300 |
-#> |.....................|   -0.9044 |   -0.3493 |   -0.7656 |   -0.7799 |
-#> |.....................|   -0.9925 |   -0.5865 |   -0.7057 |   -0.6237 |
-#> |    U|     477.01144 |     93.31 |    -5.462 |   -0.9750 |   -0.1456 |
-#> |.....................|     2.241 |     1.511 |   0.03189 |    0.8334 |
-#> |.....................|    0.7723 |     1.555 |     1.243 |     1.335 |
-#> |    X|     477.01144 |     93.31 |  0.004245 |    0.2739 |    0.8645 |
-#> |.....................|     9.403 |     1.511 |   0.03189 |    0.8334 |
-#> |.....................|    0.7723 |     1.555 |     1.243 |     1.335 |
-#> |    F| Forward Diff. |     48.38 |     1.353 |   -0.3553 |  -0.05530 |
-#> |.....................| -0.006768 |    -8.661 |    -2.325 |   -0.1540 |
-#> |.....................|     2.503 |   -0.2811 |   -0.6438 |   -0.5229 |
-#> |   33|     477.99463 |     1.002 |    -1.284 |   -0.8933 |   -0.9162 |
-#> |.....................|   -0.8846 |   -0.1951 |   -0.7385 |   -0.7367 |
-#> |.....................|    -1.093 |   -0.7697 |   -0.8046 |   -0.7596 |
-#> |    U|     477.99463 |     93.20 |    -5.584 |   -0.9231 |   -0.1318 |
-#> |.....................|     2.261 |     1.604 |   0.03230 |    0.8662 |
-#> |.....................|    0.6840 |     1.333 |     1.138 |     1.190 |
-#> |    X|     477.99463 |     93.20 |  0.003757 |    0.2843 |    0.8766 |
-#> |.....................|     9.591 |     1.604 |   0.03230 |    0.8662 |
-#> |.....................|    0.6840 |     1.333 |     1.138 |     1.190 |
-#> |   34|     476.67952 |     1.000 |    -1.201 |   -0.9310 |   -0.9256 |
-#> |.....................|   -0.8981 |   -0.3000 |   -0.7569 |   -0.7662 |
-#> |.....................|    -1.025 |   -0.6445 |   -0.7370 |   -0.6668 |
-#> |    U|     476.67952 |     93.04 |    -5.501 |   -0.9585 |   -0.1412 |
-#> |.....................|     2.247 |     1.541 |   0.03202 |    0.8438 |
-#> |.....................|    0.7442 |     1.485 |     1.210 |     1.289 |
-#> |    X|     476.67952 |     93.04 |  0.004084 |    0.2772 |    0.8683 |
-#> |.....................|     9.462 |     1.541 |   0.03202 |    0.8438 |
-#> |.....................|    0.7442 |     1.485 |     1.210 |     1.289 |
-#> |    F| Forward Diff. |     3.308 |     1.138 |    0.3206 |  0.007327 |
-#> |.....................| -0.005220 |    -6.420 |    -1.952 |   -0.8085 |
-#> |.....................|   -0.4295 |    -3.531 |    -2.349 |    -2.485 |
-#> |   35|     477.00015 |    0.9939 |    -1.268 |   -0.9234 |   -0.9152 |
-#> |.....................|   -0.8823 |   -0.2647 |   -0.7585 |   -0.7168 |
-#> |.....................|   -0.9725 |   -0.6365 |   -0.7310 |   -0.6853 |
-#> |    U|     477.00015 |     92.43 |    -5.568 |   -0.9514 |   -0.1308 |
-#> |.....................|     2.263 |     1.562 |   0.03200 |    0.8813 |
-#> |.....................|    0.7898 |     1.495 |     1.216 |     1.269 |
-#> |    X|     477.00015 |     92.43 |  0.003818 |    0.2786 |    0.8774 |
-#> |.....................|     9.613 |     1.562 |   0.03200 |    0.8813 |
-#> |.....................|    0.7898 |     1.495 |     1.216 |     1.269 |
-#> |   36|     476.87328 |    0.9941 |    -1.216 |   -0.9300 |   -0.9236 |
-#> |.....................|   -0.8950 |   -0.2832 |   -0.7542 |   -0.7554 |
-#> |.....................|    -1.014 |   -0.6375 |   -0.7322 |   -0.6666 |
-#> |    U|     476.87328 |     92.45 |    -5.516 |   -0.9576 |   -0.1392 |
-#> |.....................|     2.250 |     1.551 |   0.03206 |    0.8520 |
-#> |.....................|    0.7536 |     1.493 |     1.215 |     1.289 |
-#> |    X|     476.87328 |     92.45 |  0.004024 |    0.2774 |    0.8700 |
-#> |.....................|     9.491 |     1.551 |   0.03206 |    0.8520 |
-#> |.....................|    0.7536 |     1.493 |     1.215 |     1.289 |
-#> |   37|     476.68202 |    0.9977 |    -1.202 |   -0.9313 |   -0.9256 |
-#> |.....................|   -0.8981 |   -0.2947 |   -0.7553 |   -0.7655 |
-#> |.....................|    -1.024 |   -0.6416 |   -0.7351 |   -0.6648 |
-#> |    U|     476.68202 |     92.79 |    -5.502 |   -0.9588 |   -0.1412 |
-#> |.....................|     2.247 |     1.544 |   0.03204 |    0.8443 |
-#> |.....................|    0.7445 |     1.488 |     1.212 |     1.291 |
-#> |    X|     476.68202 |     92.79 |  0.004080 |    0.2771 |    0.8683 |
-#> |.....................|     9.462 |     1.544 |   0.03204 |    0.8443 |
-#> |.....................|    0.7445 |     1.488 |     1.212 |     1.291 |
-#> |   38|     476.66620 |    0.9991 |    -1.201 |   -0.9311 |   -0.9256 |
-#> |.....................|   -0.8981 |   -0.2974 |   -0.7561 |   -0.7659 |
-#> |.....................|    -1.024 |   -0.6431 |   -0.7361 |   -0.6658 |
-#> |    U|      476.6662 |     92.92 |    -5.501 |   -0.9587 |   -0.1412 |
-#> |.....................|     2.247 |     1.542 |   0.03203 |    0.8441 |
-#> |.....................|    0.7443 |     1.487 |     1.211 |     1.290 |
-#> |    X|      476.6662 |     92.92 |  0.004082 |    0.2771 |    0.8683 |
-#> |.....................|     9.462 |     1.542 |   0.03203 |    0.8441 |
-#> |.....................|    0.7443 |     1.487 |     1.211 |     1.290 |
-#> |    F| Forward Diff. |    -16.67 |     1.127 |    0.2138 |  -0.01630 |
-#> |.....................|   -0.1134 |    -4.869 |    -1.703 |  -0.03057 |
-#> |.....................|  -0.03000 |    -2.848 |    -2.302 |    -2.432 |
-#> |   39|     476.65034 |     1.001 |    -1.204 |   -0.9308 |   -0.9253 |
-#> |.....................|   -0.8974 |   -0.2967 |   -0.7561 |   -0.7660 |
-#> |.....................|    -1.024 |   -0.6432 |   -0.7350 |   -0.6655 |
-#> |    U|     476.65034 |     93.06 |    -5.504 |   -0.9584 |   -0.1409 |
-#> |.....................|     2.248 |     1.543 |   0.03203 |    0.8440 |
-#> |.....................|    0.7448 |     1.487 |     1.212 |     1.290 |
-#> |    X|     476.65034 |     93.06 |  0.004070 |    0.2772 |    0.8686 |
-#> |.....................|     9.468 |     1.543 |   0.03203 |    0.8440 |
-#> |.....................|    0.7448 |     1.487 |     1.212 |     1.290 |
-#> |    F| Forward Diff. |     7.111 |     1.131 |    0.3498 |   0.02199 |
-#> |.....................|   0.03596 |    -6.336 |    -1.893 |   -0.8646 |
-#> |.....................|   -0.4089 |    -3.511 |    -2.253 |    -2.437 |
-#> |   40|     476.63921 |    0.9998 |    -1.207 |   -0.9306 |   -0.9249 |
-#> |.....................|   -0.8968 |   -0.2957 |   -0.7561 |   -0.7661 |
-#> |.....................|    -1.024 |   -0.6430 |   -0.7338 |   -0.6650 |
-#> |    U|     476.63921 |     92.98 |    -5.507 |   -0.9581 |   -0.1405 |
-#> |.....................|     2.249 |     1.543 |   0.03203 |    0.8439 |
-#> |.....................|    0.7451 |     1.487 |     1.213 |     1.291 |
-#> |    X|     476.63921 |     92.98 |  0.004058 |    0.2773 |    0.8689 |
-#> |.....................|     9.474 |     1.543 |   0.03203 |    0.8439 |
-#> |.....................|    0.7451 |     1.487 |     1.213 |     1.291 |
-#> |    F| Forward Diff. |    -6.837 |     1.116 |    0.2875 |   0.01149 |
-#> |.....................|  -0.02542 |    -4.741 |    -1.572 |   0.01643 |
-#> |.....................|    -1.427 |    -2.805 |    -2.162 |    -2.393 |
-#> |   41|     476.63321 |     1.001 |    -1.209 |   -0.9304 |   -0.9247 |
-#> |.....................|   -0.8965 |   -0.2943 |   -0.7557 |   -0.7669 |
-#> |.....................|    -1.022 |   -0.6432 |   -0.7330 |   -0.6644 |
-#> |    U|     476.63321 |     93.07 |    -5.509 |   -0.9580 |   -0.1403 |
-#> |.....................|     2.249 |     1.544 |   0.03204 |    0.8433 |
-#> |.....................|    0.7468 |     1.487 |     1.214 |     1.292 |
-#> |    X|     476.63321 |     93.07 |  0.004050 |    0.2773 |    0.8691 |
-#> |.....................|     9.477 |     1.544 |   0.03204 |    0.8433 |
-#> |.....................|    0.7468 |     1.487 |     1.214 |     1.292 |
-#> |    F| Forward Diff. |     8.780 |     1.119 |    0.3715 |   0.03544 |
-#> |.....................|   0.06786 |    -4.773 |    -1.470 |  -0.02124 |
-#> |.....................|    -1.265 |    -2.850 |    -2.132 |    -2.390 |
-#> |   42|     476.62737 |    0.9998 |    -1.211 |   -0.9303 |   -0.9246 |
-#> |.....................|   -0.8963 |   -0.2932 |   -0.7554 |   -0.7683 |
-#> |.....................|    -1.020 |   -0.6436 |   -0.7322 |   -0.6637 |
-#> |    U|     476.62737 |     92.98 |    -5.511 |   -0.9578 |   -0.1402 |
-#> |.....................|     2.249 |     1.545 |   0.03204 |    0.8422 |
-#> |.....................|    0.7485 |     1.486 |     1.215 |     1.292 |
-#> |    X|     476.62737 |     92.98 |  0.004043 |    0.2773 |    0.8692 |
-#> |.....................|     9.479 |     1.545 |   0.03204 |    0.8422 |
-#> |.....................|    0.7485 |     1.486 |     1.215 |     1.292 |
-#> |    F| Forward Diff. |    -5.468 |     1.108 |    0.2964 |   0.01787 |
-#> |.....................|  -0.01029 |    -4.584 |    -1.512 |  -0.04750 |
-#> |.....................|    -1.233 |    -2.839 |    -2.097 |    -2.338 |
-#> |   43|     476.62183 |     1.001 |    -1.213 |   -0.9301 |   -0.9245 |
-#> |.....................|   -0.8960 |   -0.2918 |   -0.7549 |   -0.7696 |
-#> |.....................|    -1.018 |   -0.6438 |   -0.7313 |   -0.6628 |
-#> |    U|     476.62183 |     93.07 |    -5.513 |   -0.9577 |   -0.1401 |
-#> |.....................|     2.249 |     1.546 |   0.03205 |    0.8412 |
-#> |.....................|    0.7501 |     1.486 |     1.216 |     1.293 |
-#> |    X|     476.62183 |     93.07 |  0.004035 |    0.2773 |    0.8693 |
-#> |.....................|     9.481 |     1.546 |   0.03205 |    0.8412 |
-#> |.....................|    0.7501 |     1.486 |     1.216 |     1.293 |
-#> |    F| Forward Diff. |     8.726 |     1.111 |    0.3721 |   0.03969 |
-#> |.....................|   0.07339 |    -4.588 |    -1.391 |  -0.04583 |
-#> |.....................|    -1.059 |    -2.851 |    -2.052 |    -2.306 |
-#> |   44|     476.61645 |    0.9998 |    -1.215 |   -0.9300 |   -0.9243 |
-#> |.....................|   -0.8958 |   -0.2908 |   -0.7546 |   -0.7711 |
-#> |.....................|    -1.016 |   -0.6442 |   -0.7306 |   -0.6621 |
-#> |    U|     476.61645 |     92.98 |    -5.515 |   -0.9576 |   -0.1399 |
-#> |.....................|     2.250 |     1.546 |   0.03205 |    0.8401 |
-#> |.....................|    0.7517 |     1.485 |     1.217 |     1.294 |
-#> |    X|     476.61645 |     92.98 |  0.004027 |    0.2774 |    0.8694 |
-#> |.....................|     9.484 |     1.546 |   0.03205 |    0.8401 |
-#> |.....................|    0.7517 |     1.485 |     1.217 |     1.294 |
-#> |    F| Forward Diff. |    -5.224 |     1.099 |    0.2980 |   0.02349 |
-#> |.....................| -0.002638 |    -4.438 |    -1.447 |  -0.09166 |
-#> |.....................|    0.4490 |    -2.896 |    -2.021 |    -2.267 |
-#> |   45|     476.60491 |     1.001 |    -1.217 |   -0.9300 |   -0.9242 |
-#> |.....................|   -0.8956 |   -0.2899 |   -0.7543 |   -0.7729 |
-#> |.....................|    -1.016 |   -0.6437 |   -0.7294 |   -0.6608 |
-#> |    U|     476.60491 |     93.08 |    -5.517 |   -0.9576 |   -0.1398 |
-#> |.....................|     2.250 |     1.547 |   0.03206 |    0.8387 |
-#> |.....................|    0.7514 |     1.486 |     1.218 |     1.295 |
-#> |    X|     476.60491 |     93.08 |  0.004018 |    0.2774 |    0.8695 |
-#> |.....................|     9.485 |     1.547 |   0.03206 |    0.8387 |
-#> |.....................|    0.7514 |     1.486 |     1.218 |     1.295 |
-#> |    F| Forward Diff. |     9.891 |     1.101 |    0.3805 |   0.04781 |
-#> |.....................|   0.09121 |    -4.602 |    -1.355 |   -0.1211 |
-#> |.....................|   -0.9908 |    -2.875 |    -1.954 |    -2.212 |
-#> |   46|     476.59275 |    0.9999 |    -1.219 |   -0.9301 |   -0.9241 |
-#> |.....................|   -0.8954 |   -0.2896 |   -0.7542 |   -0.7748 |
-#> |.....................|    -1.017 |   -0.6434 |   -0.7284 |   -0.6597 |
-#> |    U|     476.59275 |     92.99 |    -5.519 |   -0.9576 |   -0.1397 |
-#> |.....................|     2.250 |     1.547 |   0.03206 |    0.8373 |
-#> |.....................|    0.7512 |     1.486 |     1.219 |     1.297 |
-#> |    X|     476.59275 |     92.99 |  0.004009 |    0.2774 |    0.8696 |
-#> |.....................|     9.487 |     1.547 |   0.03206 |    0.8373 |
-#> |.....................|    0.7512 |     1.486 |     1.219 |     1.297 |
-#> |    F| Forward Diff. |    -4.741 |     1.086 |    0.3018 |   0.02978 |
-#> |.....................|   0.01334 |    -4.300 |    -1.393 |  -0.08082 |
-#> |.....................|    0.4335 |    -2.821 |    -1.884 |    -2.156 |
-#> |   47|     476.58049 |     1.001 |    -1.222 |   -0.9302 |   -0.9241 |
-#> |.....................|   -0.8953 |   -0.2889 |   -0.7541 |   -0.7767 |
-#> |.....................|    -1.017 |   -0.6427 |   -0.7275 |   -0.6585 |
-#> |    U|     476.58049 |     93.06 |    -5.522 |   -0.9577 |   -0.1397 |
-#> |.....................|     2.250 |     1.547 |   0.03206 |    0.8359 |
-#> |.....................|    0.7507 |     1.487 |     1.220 |     1.298 |
-#> |    X|     476.58049 |     93.06 |  0.003999 |    0.2773 |    0.8697 |
-#> |.....................|     9.488 |     1.547 |   0.03206 |    0.8359 |
-#> |.....................|    0.7507 |     1.487 |     1.220 |     1.298 |
-#> |   48|     476.57085 |     1.001 |    -1.225 |   -0.9302 |   -0.9239 |
-#> |.....................|   -0.8951 |   -0.2891 |   -0.7542 |   -0.7796 |
-#> |.....................|    -1.018 |   -0.6424 |   -0.7265 |   -0.6573 |
-#> |    U|     476.57085 |     93.06 |    -5.525 |   -0.9578 |   -0.1395 |
-#> |.....................|     2.250 |     1.547 |   0.03206 |    0.8336 |
-#> |.....................|    0.7502 |     1.488 |     1.221 |     1.299 |
-#> |    X|     476.57085 |     93.06 |  0.003985 |    0.2773 |    0.8698 |
-#> |.....................|     9.490 |     1.547 |   0.03206 |    0.8336 |
-#> |.....................|    0.7502 |     1.488 |     1.221 |     1.299 |
-#> |   49|     476.52700 |     1.000 |    -1.243 |   -0.9306 |   -0.9233 |
-#> |.....................|   -0.8940 |   -0.2898 |   -0.7549 |   -0.7948 |
-#> |.....................|    -1.021 |   -0.6409 |   -0.7216 |   -0.6509 |
-#> |    U|       476.527 |     93.02 |    -5.543 |   -0.9582 |   -0.1389 |
-#> |.....................|     2.251 |     1.547 |   0.03205 |    0.8221 |
-#> |.....................|    0.7475 |     1.489 |     1.226 |     1.306 |
-#> |    X|       476.527 |     93.02 |  0.003915 |    0.2772 |    0.8703 |
-#> |.....................|     9.501 |     1.547 |   0.03205 |    0.8221 |
-#> |.....................|    0.7475 |     1.489 |     1.226 |     1.306 |
-#> |   50|     476.45166 |    0.9988 |    -1.314 |   -0.9321 |   -0.9209 |
-#> |.....................|   -0.8895 |   -0.2927 |   -0.7576 |   -0.8554 |
-#> |.....................|    -1.033 |   -0.6351 |   -0.7022 |   -0.6254 |
-#> |    U|     476.45166 |     92.89 |    -5.614 |   -0.9596 |   -0.1365 |
-#> |.....................|     2.256 |     1.545 |   0.03201 |    0.7760 |
-#> |.....................|    0.7365 |     1.496 |     1.247 |     1.333 |
-#> |    X|     476.45166 |     92.89 |  0.003648 |    0.2770 |    0.8724 |
-#> |.....................|     9.543 |     1.545 |   0.03201 |    0.7760 |
-#> |.....................|    0.7365 |     1.496 |     1.247 |     1.333 |
-#> |    F| Forward Diff. |    -21.31 |    0.8191 |    0.2022 |    0.1018 |
-#> |.....................|    0.1327 |    -4.505 |    -1.303 |    -1.202 |
-#> |.....................|    -2.080 |    -2.304 |   -0.3706 |   -0.4948 |
-#> |   51|     476.56836 |     1.004 |    -1.424 |   -0.9336 |   -0.9183 |
-#> |.....................|   -0.8856 |   -0.2810 |   -0.7637 |   -0.9206 |
-#> |.....................|    -1.004 |   -0.6303 |   -0.6962 |   -0.6148 |
-#> |    U|     476.56836 |     93.36 |    -5.724 |   -0.9609 |   -0.1338 |
-#> |.....................|     2.260 |     1.552 |   0.03192 |    0.7265 |
-#> |.....................|    0.7619 |     1.502 |     1.254 |     1.345 |
-#> |    X|     476.56836 |     93.36 |  0.003266 |    0.2767 |    0.8747 |
-#> |.....................|     9.581 |     1.552 |   0.03192 |    0.7265 |
-#> |.....................|    0.7619 |     1.502 |     1.254 |     1.345 |
-#> |   52|     476.44457 |     1.002 |    -1.351 |   -0.9326 |   -0.9200 |
-#> |.....................|   -0.8882 |   -0.2885 |   -0.7595 |   -0.8773 |
-#> |.....................|    -1.024 |   -0.6333 |   -0.7001 |   -0.6218 |
-#> |    U|     476.44457 |     93.15 |    -5.651 |   -0.9600 |   -0.1356 |
-#> |.....................|     2.257 |     1.548 |   0.03198 |    0.7594 |
-#> |.....................|    0.7451 |     1.499 |     1.249 |     1.337 |
-#> |    X|     476.44457 |     93.15 |  0.003514 |    0.2769 |    0.8732 |
-#> |.....................|     9.556 |     1.548 |   0.03198 |    0.7594 |
-#> |.....................|    0.7451 |     1.499 |     1.249 |     1.337 |
-#> |    F| Forward Diff. |     15.82 |    0.7276 |    0.3571 |    0.1746 |
-#> |.....................|    0.4004 |    -4.436 |   -0.9222 |    -1.572 |
-#> |.....................|    -1.287 |    -2.164 |   -0.2873 |   -0.3883 |
-#> |   53|     476.40417 |     1.000 |    -1.371 |   -0.9349 |   -0.9209 |
-#> |.....................|   -0.8904 |   -0.2869 |   -0.7634 |   -0.8782 |
-#> |.....................|    -1.024 |   -0.6262 |   -0.7046 |   -0.6250 |
-#> |    U|     476.40417 |     93.02 |    -5.671 |   -0.9622 |   -0.1365 |
-#> |.....................|     2.255 |     1.549 |   0.03192 |    0.7587 |
-#> |.....................|    0.7444 |     1.507 |     1.245 |     1.334 |
-#> |    X|     476.40417 |     93.02 |  0.003446 |    0.2764 |    0.8724 |
-#> |.....................|     9.535 |     1.549 |   0.03192 |    0.7587 |
-#> |.....................|    0.7444 |     1.507 |     1.245 |     1.334 |
-#> |   54|     476.37918 |     1.000 |    -1.391 |   -0.9372 |   -0.9218 |
-#> |.....................|   -0.8927 |   -0.2856 |   -0.7675 |   -0.8792 |
-#> |.....................|    -1.025 |   -0.6191 |   -0.7092 |   -0.6283 |
-#> |    U|     476.37918 |     93.03 |    -5.691 |   -0.9644 |   -0.1374 |
-#> |.....................|     2.253 |     1.549 |   0.03186 |    0.7580 |
-#> |.....................|    0.7434 |     1.516 |     1.240 |     1.330 |
-#> |    X|     476.37918 |     93.03 |  0.003376 |    0.2760 |    0.8716 |
-#> |.....................|     9.513 |     1.549 |   0.03186 |    0.7580 |
-#> |.....................|    0.7434 |     1.516 |     1.240 |     1.330 |
-#> |   55|     476.33357 |     1.001 |    -1.461 |   -0.9453 |   -0.9249 |
-#> |.....................|   -0.9004 |   -0.2814 |   -0.7818 |   -0.8827 |
-#> |.....................|    -1.029 |   -0.5944 |   -0.7253 |   -0.6399 |
-#> |    U|     476.33357 |     93.07 |    -5.761 |   -0.9719 |   -0.1405 |
-#> |.....................|     2.245 |     1.552 |   0.03165 |    0.7553 |
-#> |.....................|    0.7403 |     1.546 |     1.222 |     1.318 |
-#> |    X|     476.33357 |     93.07 |  0.003146 |    0.2745 |    0.8689 |
-#> |.....................|     9.440 |     1.552 |   0.03165 |    0.7553 |
-#> |.....................|    0.7403 |     1.546 |     1.222 |     1.318 |
-#> |    F| Forward Diff. |    -1.553 |    0.4475 |   -0.2195 |   0.07220 |
-#> |.....................|   0.05655 |    -4.350 |    -1.061 |    -1.750 |
-#> |.....................|    0.1436 |   -0.4527 |    -1.673 |    -1.245 |
-#> |   56|     476.20746 |     1.002 |    -1.571 |   -0.9452 |   -0.9313 |
-#> |.....................|   -0.9123 |   -0.2680 |   -0.8139 |   -0.8382 |
-#> |.....................|    -1.032 |   -0.6009 |   -0.7081 |   -0.6381 |
-#> |    U|     476.20746 |     93.20 |    -5.871 |   -0.9719 |   -0.1469 |
-#> |.....................|     2.233 |     1.560 |   0.03117 |    0.7891 |
-#> |.....................|    0.7373 |     1.538 |     1.241 |     1.320 |
-#> |    X|     476.20746 |     93.20 |  0.002821 |    0.2745 |    0.8634 |
-#> |.....................|     9.328 |     1.560 |   0.03117 |    0.7891 |
-#> |.....................|    0.7373 |     1.538 |     1.241 |     1.320 |
-#> |    F| Forward Diff. |     12.15 |    0.1791 |  -0.01894 | -0.004675 |
-#> |.....................|  -0.06593 |    -5.850 |    -1.512 |    -1.794 |
-#> |.....................|    -1.396 |    -1.647 |   -0.7085 |    -1.309 |
-#> |   57|     476.15444 |     1.000 |    -1.669 |   -0.9317 |   -0.9229 |
-#> |.....................|   -0.8889 |   -0.2480 |   -0.8424 |   -0.7961 |
-#> |.....................|    -1.030 |   -0.6117 |   -0.7275 |   -0.5959 |
-#> |    U|     476.15444 |     93.03 |    -5.969 |   -0.9591 |   -0.1385 |
-#> |.....................|     2.256 |     1.572 |   0.03074 |    0.8211 |
-#> |.....................|    0.7395 |     1.525 |     1.220 |     1.365 |
-#> |    X|     476.15444 |     93.03 |  0.002558 |    0.2771 |    0.8707 |
-#> |.....................|     9.549 |     1.572 |   0.03074 |    0.8211 |
-#> |.....................|    0.7395 |     1.525 |     1.220 |     1.365 |
-#> |    F| Forward Diff. |    -13.97 |  -0.09883 |    0.5245 |    0.1410 |
-#> |.....................|    0.5845 |    -3.407 |    -1.272 |   -0.2800 |
-#> |.....................|    0.9652 |    -1.487 |    -1.684 |    0.3572 |
-#> |   58|     476.18235 |     1.000 |    -1.690 |   -0.9781 |   -0.8961 |
-#> |.....................|   -0.8818 |   -0.1915 |   -0.8548 |   -0.7635 |
-#> |.....................|    -1.041 |   -0.6068 |   -0.6702 |   -0.6625 |
-#> |    U|     476.18235 |     93.04 |    -5.990 |    -1.003 |   -0.1117 |
-#> |.....................|     2.264 |     1.606 |   0.03055 |    0.8458 |
-#> |.....................|    0.7299 |     1.531 |     1.281 |     1.294 |
-#> |    X|     476.18235 |     93.04 |  0.002505 |    0.2684 |    0.8943 |
-#> |.....................|     9.617 |     1.606 |   0.03055 |    0.8458 |
-#> |.....................|    0.7299 |     1.531 |     1.281 |     1.294 |
-#> |   59|     476.08231 |     1.003 |    -1.678 |   -0.9530 |   -0.9107 |
-#> |.....................|   -0.8858 |   -0.2215 |   -0.8479 |   -0.7811 |
-#> |.....................|    -1.035 |   -0.6092 |   -0.7010 |   -0.6265 |
-#> |    U|     476.08231 |     93.25 |    -5.978 |   -0.9792 |   -0.1263 |
-#> |.....................|     2.260 |     1.588 |   0.03066 |    0.8325 |
-#> |.....................|    0.7350 |     1.528 |     1.248 |     1.332 |
-#> |    X|     476.08231 |     93.25 |  0.002533 |    0.2730 |    0.8814 |
-#> |.....................|     9.579 |     1.588 |   0.03066 |    0.8325 |
-#> |.....................|    0.7350 |     1.528 |     1.248 |     1.332 |
-#> |    F| Forward Diff. |     18.25 |  -0.08933 |   -0.2508 |    0.5157 |
-#> |.....................|    0.8830 |    -3.835 |    -1.133 |    -1.026 |
-#> |.....................|    -1.010 |    -2.153 |   -0.2439 |    -1.007 |
-#> |   60|     476.03808 |     1.001 |    -1.672 |   -0.9320 |   -0.9310 |
-#> |.....................|   -0.9291 |   -0.2079 |   -0.8419 |   -0.7733 |
-#> |.....................|    -1.039 |   -0.6026 |   -0.6913 |   -0.6380 |
-#> |    U|     476.03808 |     93.13 |    -5.972 |   -0.9594 |   -0.1466 |
-#> |.....................|     2.216 |     1.596 |   0.03074 |    0.8384 |
-#> |.....................|    0.7314 |     1.536 |     1.259 |     1.320 |
-#> |    X|     476.03808 |     93.13 |  0.002548 |    0.2770 |    0.8636 |
-#> |.....................|     9.173 |     1.596 |   0.03074 |    0.8384 |
-#> |.....................|    0.7314 |     1.536 |     1.259 |     1.320 |
-#> |    F| Forward Diff. |    -5.407 |  -0.06545 |    0.6727 |   0.05373 |
-#> |.....................|   -0.4541 |    -1.330 |   -0.5709 |   -0.1224 |
-#> |.....................|   -0.8702 |    -1.228 |    0.2640 |    -1.506 |
-#> |   61|     476.03300 |     1.003 |    -1.664 |   -0.9621 |   -0.9598 |
-#> |.....................|   -0.9520 |   -0.2020 |   -0.8337 |   -0.7650 |
-#> |.....................|    -1.042 |   -0.6106 |   -0.7076 |   -0.6154 |
-#> |    U|       476.033 |     93.29 |    -5.964 |   -0.9878 |   -0.1754 |
-#> |.....................|     2.193 |     1.599 |   0.03087 |    0.8447 |
-#> |.....................|    0.7289 |     1.526 |     1.241 |     1.344 |
-#> |    X|       476.033 |     93.29 |  0.002569 |    0.2714 |    0.8391 |
-#> |.....................|     8.966 |     1.599 |   0.03087 |    0.8447 |
-#> |.....................|    0.7289 |     1.526 |     1.241 |     1.344 |
-#> |    F| Forward Diff. |     15.25 | -0.008049 |   -0.5780 |   -0.5632 |
-#> |.....................|   -0.9601 |   -0.9870 |   -0.1614 |  -0.08306 |
-#> |.....................|    0.3446 |    -1.564 |   -0.5735 |   -0.5777 |
-#> |   62|     475.98457 |     1.001 |    -1.657 |   -0.9620 |   -0.9650 |
-#> |.....................|   -0.9284 |   -0.2016 |   -0.8312 |   -0.7567 |
-#> |.....................|    -1.045 |   -0.6004 |   -0.7091 |   -0.6133 |
-#> |    U|     475.98457 |     93.13 |    -5.957 |   -0.9877 |   -0.1806 |
-#> |.....................|     2.217 |     1.600 |   0.03091 |    0.8511 |
-#> |.....................|    0.7262 |     1.538 |     1.240 |     1.346 |
-#> |    X|     475.98457 |     93.13 |  0.002588 |    0.2714 |    0.8347 |
-#> |.....................|     9.180 |     1.600 |   0.03091 |    0.8511 |
-#> |.....................|    0.7262 |     1.538 |     1.240 |     1.346 |
-#> |   63|     475.96536 |     1.003 |    -1.649 |   -0.9620 |   -0.9705 |
-#> |.....................|   -0.9043 |   -0.2014 |   -0.8286 |   -0.7480 |
-#> |.....................|    -1.048 |   -0.5903 |   -0.7109 |   -0.6113 |
-#> |    U|     475.96536 |     93.24 |    -5.949 |   -0.9876 |   -0.1861 |
-#> |.....................|     2.241 |     1.600 |   0.03094 |    0.8576 |
-#> |.....................|    0.7235 |     1.551 |     1.238 |     1.349 |
-#> |    X|     475.96536 |     93.24 |  0.002608 |    0.2714 |    0.8302 |
-#> |.....................|     9.403 |     1.600 |   0.03094 |    0.8576 |
-#> |.....................|    0.7235 |     1.551 |     1.238 |     1.349 |
-#> |   64|     476.05821 |     1.003 |    -1.627 |   -0.9618 |   -0.9866 |
-#> |.....................|   -0.8332 |   -0.2007 |   -0.8211 |   -0.7226 |
-#> |.....................|    -1.057 |   -0.5602 |   -0.7159 |   -0.6052 |
-#> |    U|     476.05821 |     93.28 |    -5.927 |   -0.9874 |   -0.2022 |
-#> |.....................|     2.312 |     1.600 |   0.03106 |    0.8769 |
-#> |.....................|    0.7156 |     1.587 |     1.233 |     1.355 |
-#> |    X|     476.05821 |     93.28 |  0.002666 |    0.2714 |    0.8169 |
-#> |.....................|     10.10 |     1.600 |   0.03106 |    0.8769 |
-#> |.....................|    0.7156 |     1.587 |     1.233 |     1.355 |
-#> |    F| Forward Diff. |     11.90 |   0.05098 |   -0.6601 |   -0.8657 |
-#> |.....................|    0.4347 |   -0.9523 |   -0.3178 |   -0.1283 |
-#> |.....................|   -0.1024 |   -0.7800 |   -0.7284 |   -0.4981 |
-#> |   65|     476.00714 |     1.001 |    -1.643 |   -0.9512 |   -0.8390 |
-#> |.....................|   -0.8932 |   -0.2051 |   -0.7956 |   -0.7365 |
-#> |.....................|    -1.045 |   -0.5599 |   -0.7127 |   -0.5744 |
-#> |    U|     476.00714 |     93.11 |    -5.943 |   -0.9775 |  -0.05460 |
-#> |.....................|     2.252 |     1.598 |   0.03144 |    0.8663 |
-#> |.....................|    0.7264 |     1.588 |     1.236 |     1.388 |
-#> |    X|     476.00714 |     93.11 |  0.002624 |    0.2734 |    0.9469 |
-#> |.....................|     9.508 |     1.598 |   0.03144 |    0.8663 |
-#> |.....................|    0.7264 |     1.588 |     1.236 |     1.388 |
-#> |   66|     475.93814 |     1.000 |    -1.647 |   -0.9575 |   -0.9171 |
-#> |.....................|   -0.8999 |   -0.2027 |   -0.8152 |   -0.7434 |
-#> |.....................|    -1.047 |   -0.5779 |   -0.7115 |   -0.5963 |
-#> |    U|     475.93814 |     93.01 |    -5.947 |   -0.9834 |   -0.1327 |
-#> |.....................|     2.245 |     1.599 |   0.03115 |    0.8612 |
-#> |.....................|    0.7247 |     1.566 |     1.237 |     1.365 |
-#> |    X|     475.93814 |     93.01 |  0.002614 |    0.2722 |    0.8757 |
-#> |.....................|     9.445 |     1.599 |   0.03115 |    0.8612 |
-#> |.....................|    0.7247 |     1.566 |     1.237 |     1.365 |
-#> |    F| Forward Diff. |    -23.67 |   0.03897 |   -0.7058 |    0.2979 |
-#> |.....................|    0.2507 |   -0.5051 |   -0.4675 |  -0.05050 |
-#> |.....................|    -1.329 |   -0.1594 |   -0.7628 |    0.1885 |
-#> |   67|     475.98668 |     1.003 |    -1.653 |   -0.9119 |   -0.8938 |
-#> |.....................|   -0.8940 |   -0.2050 |   -0.7980 |   -0.7479 |
-#> |.....................|    -1.040 |   -0.5617 |   -0.7056 |   -0.5853 |
-#> |    U|     475.98668 |     93.26 |    -5.953 |   -0.9406 |   -0.1094 |
-#> |.....................|     2.251 |     1.598 |   0.03140 |    0.8577 |
-#> |.....................|    0.7310 |     1.586 |     1.243 |     1.376 |
-#> |    X|     475.98668 |     93.26 |  0.002598 |    0.2808 |    0.8964 |
-#> |.....................|     9.501 |     1.598 |   0.03140 |    0.8577 |
-#> |.....................|    0.7310 |     1.586 |     1.243 |     1.376 |
-#> |   68|     475.93401 |     1.003 |    -1.649 |   -0.9419 |   -0.9092 |
-#> |.....................|   -0.8979 |   -0.2035 |   -0.8093 |   -0.7449 |
-#> |.....................|    -1.044 |   -0.5723 |   -0.7094 |   -0.5925 |
-#> |    U|     475.93401 |     93.26 |    -5.949 |   -0.9687 |   -0.1248 |
-#> |.....................|     2.247 |     1.599 |   0.03123 |    0.8600 |
-#> |.....................|    0.7270 |     1.573 |     1.239 |     1.369 |
-#> |    X|     475.93401 |     93.26 |  0.002609 |    0.2751 |    0.8827 |
-#> |.....................|     9.464 |     1.599 |   0.03123 |    0.8600 |
-#> |.....................|    0.7270 |     1.573 |     1.239 |     1.369 |
-#> |    F| Forward Diff. |     21.62 |   0.03755 |    0.3553 |    0.5344 |
-#> |.....................|    0.5780 |   -0.8226 |   -0.2181 |   -0.2167 |
-#> |.....................|    -1.049 |  0.002537 |   -0.7279 |    0.2347 |
-#> |   69|     475.92580 |     1.001 |    -1.653 |   -0.9417 |   -0.9124 |
-#> |.....................|   -0.8966 |   -0.2037 |   -0.8058 |   -0.7501 |
-#> |.....................|    -1.041 |   -0.5739 |   -0.7048 |   -0.5926 |
-#> |    U|      475.9258 |     93.12 |    -5.953 |   -0.9686 |   -0.1280 |
-#> |.....................|     2.249 |     1.598 |   0.03129 |    0.8560 |
-#> |.....................|    0.7297 |     1.571 |     1.244 |     1.369 |
-#> |    X|      475.9258 |     93.12 |  0.002598 |    0.2752 |    0.8798 |
-#> |.....................|     9.476 |     1.598 |   0.03129 |    0.8560 |
-#> |.....................|    0.7297 |     1.571 |     1.244 |     1.369 |
-#> |    F| Forward Diff. |    -1.238 |  0.003180 |    0.2025 |    0.4289 |
-#> |.....................|    0.4493 |   -0.2935 |   -0.2270 |   -0.1209 |
-#> |.....................|    0.3327 |  -0.04065 |   -0.4864 |    0.2705 |
-#> |   70|     475.92421 |     1.002 |    -1.655 |   -0.9475 |   -0.9180 |
-#> |.....................|   -0.8971 |   -0.2051 |   -0.8017 |   -0.7499 |
-#> |.....................|    -1.041 |   -0.5760 |   -0.7024 |   -0.5951 |
-#> |    U|     475.92421 |     93.14 |    -5.955 |   -0.9740 |   -0.1336 |
-#> |.....................|     2.248 |     1.598 |   0.03135 |    0.8562 |
-#> |.....................|    0.7299 |     1.568 |     1.247 |     1.366 |
-#> |    X|     475.92421 |     93.14 |  0.002593 |    0.2741 |    0.8749 |
-#> |.....................|     9.472 |     1.598 |   0.03135 |    0.8562 |
-#> |.....................|    0.7299 |     1.568 |     1.247 |     1.366 |
-#> |    F| Forward Diff. |     1.572 | 0.0005078 |  -0.07939 |    0.3039 |
-#> |.....................|    0.4520 |   -0.5123 |   -0.2298 |   -0.1955 |
-#> |.....................|    0.3506 |   -0.1759 |   -0.3471 |    0.1717 |
-#> |   71|     475.91356 |     1.001 |    -1.654 |   -0.9476 |   -0.9223 |
-#> |.....................|   -0.8992 |   -0.2071 |   -0.7965 |   -0.7440 |
-#> |.....................|    -1.043 |   -0.5749 |   -0.7035 |   -0.5974 |
-#> |    U|     475.91356 |     93.12 |    -5.954 |   -0.9741 |   -0.1379 |
-#> |.....................|     2.246 |     1.596 |   0.03143 |    0.8607 |
-#> |.....................|    0.7278 |     1.569 |     1.246 |     1.363 |
-#> |    X|     475.91356 |     93.12 |  0.002596 |    0.2741 |    0.8712 |
-#> |.....................|     9.452 |     1.596 |   0.03143 |    0.8607 |
-#> |.....................|    0.7278 |     1.569 |     1.246 |     1.363 |
-#> |   72|     475.89054 |     1.001 |    -1.650 |   -0.9479 |   -0.9349 |
-#> |.....................|   -0.9054 |   -0.2136 |   -0.7808 |   -0.7261 |
-#> |.....................|    -1.051 |   -0.5716 |   -0.7071 |   -0.6043 |
-#> |    U|     475.89054 |     93.11 |    -5.950 |   -0.9744 |   -0.1505 |
-#> |.....................|     2.240 |     1.592 |   0.03166 |    0.8742 |
-#> |.....................|    0.7214 |     1.574 |     1.242 |     1.356 |
-#> |    X|     475.89054 |     93.11 |  0.002606 |    0.2740 |    0.8602 |
-#> |.....................|     9.393 |     1.592 |   0.03166 |    0.8742 |
-#> |.....................|    0.7214 |     1.574 |     1.242 |     1.356 |
-#> |    F| Forward Diff. |    -3.467 |   0.05330 |   -0.1133 |   -0.1045 |
-#> |.....................|    0.1362 |   -0.3304 |   -0.2172 |   0.04726 |
-#> |.....................|    -1.416 |   0.08323 |   -0.4566 |   -0.2851 |
-#> |   73|     476.06529 |     1.002 |    -1.688 |   -0.8959 |   -0.9784 |
-#> |.....................|   -0.9076 |   -0.2354 |   -0.6823 |   -0.7302 |
-#> |.....................|    -1.035 |   -0.5603 |   -0.6700 |   -0.6079 |
-#> |    U|     476.06529 |     93.20 |    -5.988 |   -0.9255 |   -0.1940 |
-#> |.....................|     2.238 |     1.579 |   0.03314 |    0.8712 |
-#> |.....................|    0.7347 |     1.587 |     1.281 |     1.352 |
-#> |    X|     476.06529 |     93.20 |  0.002510 |    0.2838 |    0.8236 |
-#> |.....................|     9.372 |     1.579 |   0.03314 |    0.8712 |
-#> |.....................|    0.7347 |     1.587 |     1.281 |     1.352 |
-#> |   74|     475.89054 |     1.001 |    -1.650 |   -0.9479 |   -0.9349 |
-#> |.....................|   -0.9054 |   -0.2136 |   -0.7808 |   -0.7261 |
-#> |.....................|    -1.051 |   -0.5716 |   -0.7071 |   -0.6043 |
-#> |    U|     475.89054 |     93.11 |    -5.950 |   -0.9744 |   -0.1505 |
-#> |.....................|     2.240 |     1.592 |   0.03166 |    0.8742 |
-#> |.....................|    0.7214 |     1.574 |     1.242 |     1.356 |
-#> |    X|     475.89054 |     93.11 |  0.002606 |    0.2740 |    0.8602 |
-#> |.....................|     9.393 |     1.592 |   0.03166 |    0.8742 |
-#> |.....................|    0.7214 |     1.574 |     1.242 |     1.356 |
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-f_nlmixr_dfop_sfo_focei_tc <- nlmixr(f_mmkin_tc["DFOP-SFO", ], est = "focei")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
-#> F: Forward difference gradient approximation
-#> C: Central difference gradient approximation
-#> M: Mixed forward and central difference gradient approximation
-#> Unscaled parameters for Omegas=chol(solve(omega));
-#> Diagonals are transformed, as specified by foceiControl(diagXform=)
-#> |-----+---------------+-----------+-----------+-----------+-----------|
-#> |    #| Objective Fun |  parent_0 |  log_k_A1 |f_parent_qlogis |    log_k1 |
-#> |.....................|    log_k2 |  g_qlogis | sigma_low |  rsd_high |
-#> |.....................|        o1 |        o2 |        o3 |        o4 |
-#> |.....................|        o5 |        o6 |...........|...........|
-#> |    1|     495.48573 |     1.000 |    -1.000 |   -0.9104 |   -0.9376 |
-#> |.....................|   -0.9875 |   -0.8823 |   -0.8746 |   -0.8907 |
-#> |.....................|   -0.8767 |   -0.8731 |   -0.8673 |   -0.8720 |
-#> |.....................|   -0.8739 |   -0.8666 |...........|...........|
-#> |    U|     495.48573 |     91.00 |    -5.200 |   -0.8900 |    -2.200 |
-#> |.....................|    -4.600 |    0.4600 |    0.8300 |   0.05800 |
-#> |.....................|    0.7311 |    0.9036 |     1.183 |    0.9554 |
-#> |.....................|    0.8633 |     1.214 |...........|...........|
-#> |    X|     495.48573 |     91.00 |  0.005517 |    0.2911 |    0.1108 |
-#> |.....................|   0.01005 |    0.6130 |    0.8300 |   0.05800 |
-#> |.....................|    0.7311 |    0.9036 |     1.183 |    0.9554 |
-#> |.....................|    0.8633 |     1.214 |...........|...........|
-#> |    G|    Gill Diff. |   -0.9650 |     2.223 |   -0.3153 |  -0.01817 |
-#> |.....................|   -0.3350 |    0.6789 |    -29.17 |    -19.58 |
-#> |.....................|    0.9642 |     9.851 |    -11.94 |    -1.319 |
-#> |.....................|     8.578 |    -12.45 |...........|...........|
-#> |    2|     487.27153 |     1.023 |    -1.054 |   -0.9028 |   -0.9372 |
-#> |.....................|   -0.9794 |   -0.8987 |   -0.1695 |   -0.4175 |
-#> |.....................|   -0.9000 |    -1.111 |   -0.5788 |   -0.8401 |
-#> |.....................|    -1.081 |   -0.5657 |...........|...........|
-#> |    U|     487.27153 |     93.12 |    -5.254 |   -0.8832 |    -2.200 |
-#> |.....................|    -4.592 |    0.4525 |     1.123 |   0.07172 |
-#> |.....................|    0.7141 |    0.6884 |     1.525 |    0.9859 |
-#> |.....................|    0.6843 |     1.580 |...........|...........|
-#> |    X|     487.27153 |     93.12 |  0.005228 |    0.2925 |    0.1109 |
-#> |.....................|   0.01013 |    0.6112 |     1.123 |   0.07172 |
-#> |.....................|    0.7141 |    0.6884 |     1.525 |    0.9859 |
-#> |.....................|    0.6843 |     1.580 |...........|...........|
-#> |    F| Forward Diff. |     131.2 |     1.375 |     2.844 |   -0.2311 |
-#> |.....................|    0.2724 |    0.4206 |     9.234 |     14.82 |
-#> |.....................|   -0.3432 |    -1.547 |    -2.137 |     2.699 |
-#> |.....................|    -4.845 |    -6.389 |...........|...........|
-#> |    3|     3806.3530 |    0.1967 |    -1.082 |   -0.9181 |   -0.9356 |
-#> |.....................|   -0.9782 |   -0.9073 |   0.02635 |   -0.3409 |
-#> |.....................|   -0.9062 |    -1.204 |   -0.4610 |   -0.8458 |
-#> |.....................|    -1.125 |   -0.4164 |...........|...........|
-#> |    U|      3806.353 |     17.90 |    -5.282 |   -0.8969 |    -2.198 |
-#> |.....................|    -4.591 |    0.4485 |     1.204 |   0.07394 |
-#> |.....................|    0.7095 |    0.6043 |     1.664 |    0.9805 |
-#> |.....................|    0.6463 |     1.761 |...........|...........|
-#> |    X|      3806.353 |     17.90 |  0.005083 |    0.2897 |    0.1110 |
-#> |.....................|   0.01015 |    0.6103 |     1.204 |   0.07394 |
-#> |.....................|    0.7095 |    0.6043 |     1.664 |    0.9805 |
-#> |.....................|    0.6463 |     1.761 |...........|...........|
-#> |    4|     498.29847 |    0.9363 |    -1.055 |   -0.9047 |   -0.9370 |
-#> |.....................|   -0.9796 |   -0.8990 |   -0.1756 |   -0.4273 |
-#> |.....................|   -0.8998 |    -1.110 |   -0.5773 |   -0.8419 |
-#> |.....................|    -1.078 |   -0.5615 |...........|...........|
-#> |    U|     498.29847 |     85.20 |    -5.255 |   -0.8849 |    -2.199 |
-#> |.....................|    -4.592 |    0.4523 |     1.120 |   0.07144 |
-#> |.....................|    0.7142 |    0.6894 |     1.526 |    0.9842 |
-#> |.....................|    0.6871 |     1.585 |...........|...........|
-#> |    X|     498.29847 |     85.20 |  0.005223 |    0.2922 |    0.1109 |
-#> |.....................|   0.01013 |    0.6112 |     1.120 |   0.07144 |
-#> |.....................|    0.7142 |    0.6894 |     1.526 |    0.9842 |
-#> |.....................|    0.6871 |     1.585 |...........|...........|
-#> |    5|     485.66266 |     1.001 |    -1.054 |   -0.9033 |   -0.9372 |
-#> |.....................|   -0.9795 |   -0.8988 |   -0.1711 |   -0.4200 |
-#> |.....................|   -0.8999 |    -1.111 |   -0.5784 |   -0.8406 |
-#> |.....................|    -1.080 |   -0.5646 |...........|...........|
-#> |    U|     485.66266 |     91.08 |    -5.254 |   -0.8836 |    -2.200 |
-#> |.....................|    -4.592 |    0.4524 |     1.122 |   0.07165 |
-#> |.....................|    0.7141 |    0.6887 |     1.525 |    0.9855 |
-#> |.....................|    0.6850 |     1.581 |...........|...........|
-#> |    X|     485.66266 |     91.08 |  0.005227 |    0.2924 |    0.1109 |
-#> |.....................|   0.01013 |    0.6112 |     1.122 |   0.07165 |
-#> |.....................|    0.7141 |    0.6887 |     1.525 |    0.9855 |
-#> |.....................|    0.6850 |     1.581 |...........|...........|
-#> |    F| Forward Diff. |     5.221 |     1.276 |    0.8286 |   0.07146 |
-#> |.....................|    0.3378 |    0.6177 |     8.950 |     14.42 |
-#> |.....................|    -2.232 |    -2.934 |    -2.090 |     2.822 |
-#> |.....................|    -4.031 |    -6.085 |...........|...........|
-#> |    6|     485.32609 |    0.9950 |    -1.055 |   -0.9042 |   -0.9372 |
-#> |.....................|   -0.9799 |   -0.8995 |   -0.1813 |   -0.4364 |
-#> |.....................|   -0.8974 |    -1.108 |   -0.5760 |   -0.8438 |
-#> |.....................|    -1.076 |   -0.5577 |...........|...........|
-#> |    U|     485.32609 |     90.54 |    -5.255 |   -0.8845 |    -2.200 |
-#> |.....................|    -4.592 |    0.4521 |     1.118 |   0.07117 |
-#> |.....................|    0.7160 |    0.6917 |     1.528 |    0.9824 |
-#> |.....................|    0.6890 |     1.589 |...........|...........|
-#> |    X|     485.32609 |     90.54 |  0.005219 |    0.2922 |    0.1108 |
-#> |.....................|   0.01013 |    0.6111 |     1.118 |   0.07117 |
-#> |.....................|    0.7160 |    0.6917 |     1.528 |    0.9824 |
-#> |.....................|    0.6890 |     1.589 |...........|...........|
-#> |    F| Forward Diff. |    -30.72 |     1.256 |    0.2407 |    0.1468 |
-#> |.....................|    0.3576 |    0.6982 |     8.550 |     13.79 |
-#> |.....................|    -2.152 |    -3.092 |    -1.869 |     2.672 |
-#> |.....................|    -3.399 |    -5.827 |...........|...........|
-#> |    7|     484.94767 |     1.003 |    -1.055 |   -0.9045 |   -0.9373 |
-#> |.....................|   -0.9801 |   -0.8996 |   -0.1956 |   -0.4497 |
-#> |.....................|   -0.8963 |    -1.103 |   -0.5795 |   -0.8455 |
-#> |.....................|    -1.071 |   -0.5595 |...........|...........|
-#> |    U|     484.94767 |     91.28 |    -5.255 |   -0.8848 |    -2.200 |
-#> |.....................|    -4.593 |    0.4521 |     1.112 |   0.07079 |
-#> |.....................|    0.7168 |    0.6961 |     1.524 |    0.9808 |
-#> |.....................|    0.6930 |     1.587 |...........|...........|
-#> |    X|     484.94767 |     91.28 |  0.005220 |    0.2922 |    0.1108 |
-#> |.....................|   0.01013 |    0.6111 |     1.112 |   0.07079 |
-#> |.....................|    0.7168 |    0.6961 |     1.524 |    0.9808 |
-#> |.....................|    0.6930 |     1.587 |...........|...........|
-#> |    F| Forward Diff. |     16.95 |     1.308 |    0.9181 |   0.03760 |
-#> |.....................|    0.3308 |    0.6549 |     8.124 |     13.74 |
-#> |.....................|    -1.975 |    -2.369 |    -2.107 |     2.437 |
-#> |.....................|    -3.334 |    -5.928 |...........|...........|
-#> |    8|     484.63747 |    0.9965 |    -1.055 |   -0.9051 |   -0.9373 |
-#> |.....................|   -0.9805 |   -0.8998 |   -0.2100 |   -0.4642 |
-#> |.....................|   -0.8952 |    -1.098 |   -0.5823 |   -0.8472 |
-#> |.....................|    -1.067 |   -0.5602 |...........|...........|
-#> |    U|     484.63747 |     90.68 |    -5.255 |   -0.8853 |    -2.200 |
-#> |.....................|    -4.593 |    0.4520 |     1.106 |   0.07037 |
-#> |.....................|    0.7176 |    0.7002 |     1.521 |    0.9792 |
-#> |.....................|    0.6968 |     1.586 |...........|...........|
-#> |    X|     484.63747 |     90.68 |  0.005220 |    0.2921 |    0.1108 |
-#> |.....................|   0.01012 |    0.6111 |     1.106 |   0.07037 |
-#> |.....................|    0.7176 |    0.7002 |     1.521 |    0.9792 |
-#> |.....................|    0.6968 |     1.586 |...........|...........|
-#> |    F| Forward Diff. |    -22.67 |     1.288 |    0.2773 |    0.1211 |
-#> |.....................|    0.3459 |    0.7203 |     8.028 |     13.24 |
-#> |.....................|    -1.967 |    -2.555 |    -2.117 |     2.333 |
-#> |.....................|    -2.789 |    -5.812 |...........|...........|
-#> |    9|     484.31288 |     1.003 |    -1.055 |   -0.9054 |   -0.9374 |
-#> |.....................|   -0.9808 |   -0.9000 |   -0.2248 |   -0.4783 |
-#> |.....................|   -0.8942 |    -1.094 |   -0.5856 |   -0.8486 |
-#> |.....................|    -1.063 |   -0.5617 |...........|...........|
-#> |    U|     484.31288 |     91.27 |    -5.255 |   -0.8855 |    -2.200 |
-#> |.....................|    -4.593 |    0.4519 |     1.100 |   0.06996 |
-#> |.....................|    0.7183 |    0.7043 |     1.517 |    0.9778 |
-#> |.....................|    0.7003 |     1.585 |...........|...........|
-#> |    X|     484.31288 |     91.27 |  0.005220 |    0.2920 |    0.1108 |
-#> |.....................|   0.01012 |    0.6111 |     1.100 |   0.06996 |
-#> |.....................|    0.7183 |    0.7043 |     1.517 |    0.9778 |
-#> |.....................|    0.7003 |     1.585 |...........|...........|
-#> |    F| Forward Diff. |     16.32 |     1.333 |    0.8110 |   0.03416 |
-#> |.....................|    0.3225 |    0.6774 |     7.502 |     12.95 |
-#> |.....................|    -1.990 |    -1.849 |    -2.190 |     2.193 |
-#> |.....................|    -2.714 |    -5.891 |...........|...........|
-#> |   10|     484.03445 |    0.9966 |    -1.055 |   -0.9058 |   -0.9374 |
-#> |.....................|   -0.9811 |   -0.9003 |   -0.2393 |   -0.4932 |
-#> |.....................|   -0.8929 |    -1.090 |   -0.5881 |   -0.8501 |
-#> |.....................|    -1.059 |   -0.5620 |...........|...........|
-#> |    U|     484.03445 |     90.69 |    -5.255 |   -0.8859 |    -2.200 |
-#> |.....................|    -4.594 |    0.4517 |     1.094 |   0.06953 |
-#> |.....................|    0.7192 |    0.7079 |     1.514 |    0.9764 |
-#> |.....................|    0.7034 |     1.584 |...........|...........|
-#> |    X|     484.03445 |     90.69 |  0.005219 |    0.2919 |    0.1108 |
-#> |.....................|   0.01012 |    0.6110 |     1.094 |   0.06953 |
-#> |.....................|    0.7192 |    0.7079 |     1.514 |    0.9764 |
-#> |.....................|    0.7034 |     1.584 |...........|...........|
-#> |    F| Forward Diff. |    -23.34 |     1.311 |    0.1997 |    0.1136 |
-#> |.....................|    0.3397 |    0.7422 |     7.043 |     12.17 |
-#> |.....................|    -1.843 |    -2.075 |    -2.300 |     2.141 |
-#> |.....................|    -2.235 |    -5.778 |...........|...........|
-#> |   11|     483.72794 |     1.003 |    -1.056 |   -0.9061 |   -0.9374 |
-#> |.....................|   -0.9815 |   -0.9008 |   -0.2540 |   -0.5081 |
-#> |.....................|   -0.8918 |    -1.086 |   -0.5906 |   -0.8514 |
-#> |.....................|    -1.056 |   -0.5623 |...........|...........|
-#> |    U|     483.72794 |     91.28 |    -5.256 |   -0.8861 |    -2.200 |
-#> |.....................|    -4.594 |    0.4515 |     1.088 |   0.06909 |
-#> |.....................|    0.7200 |    0.7113 |     1.511 |    0.9751 |
-#> |.....................|    0.7061 |     1.584 |...........|...........|
-#> |    X|     483.72794 |     91.28 |  0.005217 |    0.2919 |    0.1108 |
-#> |.....................|   0.01011 |    0.6110 |     1.088 |   0.06909 |
-#> |.....................|    0.7200 |    0.7113 |     1.511 |    0.9751 |
-#> |.....................|    0.7061 |     1.584 |...........|...........|
-#> |    F| Forward Diff. |     16.56 |     1.355 |    0.7367 |   0.03002 |
-#> |.....................|    0.3166 |    0.7021 |     6.528 |     11.89 |
-#> |.....................|    -1.880 |    -1.512 |    -2.404 |     1.917 |
-#> |.....................|    -2.215 |    -5.846 |...........|...........|
-#> |   12|     483.44272 |    0.9974 |    -1.057 |   -0.9064 |   -0.9375 |
-#> |.....................|   -0.9820 |   -0.9016 |   -0.2678 |   -0.5243 |
-#> |.....................|   -0.8904 |    -1.083 |   -0.5914 |   -0.8528 |
-#> |.....................|    -1.054 |   -0.5601 |...........|...........|
-#> |    U|     483.44272 |     90.76 |    -5.257 |   -0.8865 |    -2.200 |
-#> |.....................|    -4.594 |    0.4511 |     1.082 |   0.06862 |
-#> |.....................|    0.7211 |    0.7141 |     1.510 |    0.9738 |
-#> |.....................|    0.7081 |     1.587 |...........|...........|
-#> |    X|     483.44272 |     90.76 |  0.005212 |    0.2918 |    0.1108 |
-#> |.....................|   0.01011 |    0.6109 |     1.082 |   0.06862 |
-#> |.....................|    0.7211 |    0.7141 |     1.510 |    0.9738 |
-#> |.....................|    0.7081 |     1.587 |...........|...........|
-#> |    F| Forward Diff. |    -19.50 |     1.332 |    0.2061 |    0.1022 |
-#> |.....................|    0.3336 |    0.7519 |     5.944 |     11.09 |
-#> |.....................|    -1.878 |    -1.675 |    -2.404 |     1.054 |
-#> |.....................|    -1.833 |    -5.715 |...........|...........|
-#> |   13|     483.13758 |     1.003 |    -1.059 |   -0.9067 |   -0.9375 |
-#> |.....................|   -0.9826 |   -0.9029 |   -0.2791 |   -0.5415 |
-#> |.....................|   -0.8881 |    -1.081 |   -0.5896 |   -0.8508 |
-#> |.....................|    -1.053 |   -0.5541 |...........|...........|
-#> |    U|     483.13758 |     91.30 |    -5.259 |   -0.8867 |    -2.200 |
-#> |.....................|    -4.595 |    0.4505 |     1.077 |   0.06813 |
-#> |.....................|    0.7227 |    0.7157 |     1.512 |    0.9758 |
-#> |.....................|    0.7089 |     1.594 |...........|...........|
-#> |    X|     483.13758 |     91.30 |  0.005202 |    0.2918 |    0.1108 |
-#> |.....................|   0.01010 |    0.6108 |     1.077 |   0.06813 |
-#> |.....................|    0.7227 |    0.7157 |     1.512 |    0.9758 |
-#> |.....................|    0.7089 |     1.594 |...........|...........|
-#> |    F| Forward Diff. |     16.83 |     1.368 |    0.7006 |   0.02276 |
-#> |.....................|    0.3159 |    0.7144 |     5.487 |     10.74 |
-#> |.....................|    -1.773 |    -1.125 |    -2.251 |     1.956 |
-#> |.....................|    -1.882 |    -5.671 |...........|...........|
-#> |   14|     482.85180 |    0.9981 |    -1.062 |   -0.9072 |   -0.9376 |
-#> |.....................|   -0.9834 |   -0.9050 |   -0.2850 |   -0.5582 |
-#> |.....................|   -0.8853 |    -1.082 |   -0.5852 |   -0.8503 |
-#> |.....................|    -1.053 |   -0.5428 |...........|...........|
-#> |    U|      482.8518 |     90.83 |    -5.262 |   -0.8872 |    -2.200 |
-#> |.....................|    -4.596 |    0.4496 |     1.075 |   0.06764 |
-#> |.....................|    0.7248 |    0.7152 |     1.517 |    0.9762 |
-#> |.....................|    0.7084 |     1.607 |...........|...........|
-#> |    X|      482.8518 |     90.83 |  0.005184 |    0.2917 |    0.1108 |
-#> |.....................|   0.01009 |    0.6105 |     1.075 |   0.06764 |
-#> |.....................|    0.7248 |    0.7152 |     1.517 |    0.9762 |
-#> |.....................|    0.7084 |     1.607 |...........|...........|
-#> |    F| Forward Diff. |    -16.64 |     1.337 |    0.2421 |   0.09047 |
-#> |.....................|    0.3389 |    0.7643 |     5.051 |     10.06 |
-#> |.....................|    -1.787 |    -1.445 |    -2.047 |     2.073 |
-#> |.....................|    -1.627 |    -5.410 |...........|...........|
-#> |   15|     482.60290 |     1.003 |    -1.066 |   -0.9079 |   -0.9377 |
-#> |.....................|   -0.9844 |   -0.9075 |   -0.2858 |   -0.5723 |
-#> |.....................|   -0.8822 |    -1.083 |   -0.5806 |   -0.8571 |
-#> |.....................|    -1.055 |   -0.5294 |...........|...........|
-#> |    U|      482.6029 |     91.28 |    -5.266 |   -0.8878 |    -2.200 |
-#> |.....................|    -4.597 |    0.4484 |     1.074 |   0.06723 |
-#> |.....................|    0.7271 |    0.7136 |     1.523 |    0.9697 |
-#> |.....................|    0.7072 |     1.624 |...........|...........|
-#> |    X|      482.6029 |     91.28 |  0.005162 |    0.2916 |    0.1108 |
-#> |.....................|   0.01008 |    0.6103 |     1.074 |   0.06723 |
-#> |.....................|    0.7271 |    0.7136 |     1.523 |    0.9697 |
-#> |.....................|    0.7072 |     1.624 |...........|...........|
-#> |    F| Forward Diff. |     14.50 |     1.352 |    0.6742 |   0.02192 |
-#> |.....................|    0.3317 |    0.7297 |     4.803 |     9.894 |
-#> |.....................|    -1.694 |    -1.220 |    -2.031 |     1.506 |
-#> |.....................|    -1.722 |    -5.269 |...........|...........|
-#> |   16|     482.37953 |    0.9987 |    -1.071 |   -0.9090 |   -0.9377 |
-#> |.....................|   -0.9857 |   -0.9106 |   -0.2840 |   -0.5862 |
-#> |.....................|   -0.8787 |    -1.084 |   -0.5758 |   -0.8611 |
-#> |.....................|    -1.056 |   -0.5150 |...........|...........|
-#> |    U|     482.37953 |     90.88 |    -5.271 |   -0.8888 |    -2.200 |
-#> |.....................|    -4.598 |    0.4470 |     1.075 |   0.06683 |
-#> |.....................|    0.7296 |    0.7132 |     1.528 |    0.9659 |
-#> |.....................|    0.7058 |     1.641 |...........|...........|
-#> |    X|     482.37953 |     90.88 |  0.005137 |    0.2914 |    0.1108 |
-#> |.....................|   0.01007 |    0.6099 |     1.075 |   0.06683 |
-#> |.....................|    0.7296 |    0.7132 |     1.528 |    0.9659 |
-#> |.....................|    0.7058 |     1.641 |...........|...........|
-#> |   17|     482.17662 |    0.9986 |    -1.077 |   -0.9102 |   -0.9378 |
-#> |.....................|   -0.9871 |   -0.9141 |   -0.2800 |   -0.5994 |
-#> |.....................|   -0.8750 |    -1.085 |   -0.5707 |   -0.8654 |
-#> |.....................|    -1.059 |   -0.4996 |...........|...........|
-#> |    U|     482.17662 |     90.88 |    -5.277 |   -0.8898 |    -2.200 |
-#> |.....................|    -4.600 |    0.4454 |     1.077 |   0.06645 |
-#> |.....................|    0.7323 |    0.7123 |     1.534 |    0.9618 |
-#> |.....................|    0.7037 |     1.660 |...........|...........|
-#> |    X|     482.17662 |     90.88 |  0.005108 |    0.2911 |    0.1108 |
-#> |.....................|   0.01006 |    0.6095 |     1.077 |   0.06645 |
-#> |.....................|    0.7323 |    0.7123 |     1.534 |    0.9618 |
-#> |.....................|    0.7037 |     1.660 |...........|...........|
-#> |   18|     481.54428 |    0.9984 |    -1.097 |   -0.9142 |   -0.9379 |
-#> |.....................|   -0.9921 |   -0.9262 |   -0.2660 |   -0.6456 |
-#> |.....................|   -0.8623 |    -1.088 |   -0.5530 |   -0.8805 |
-#> |.....................|    -1.068 |   -0.4457 |...........|...........|
-#> |    U|     481.54428 |     90.86 |    -5.297 |   -0.8934 |    -2.200 |
-#> |.....................|    -4.605 |    0.4398 |     1.083 |   0.06511 |
-#> |.....................|    0.7417 |    0.7091 |     1.555 |    0.9473 |
-#> |.....................|    0.6961 |     1.725 |...........|...........|
-#> |    X|     481.54428 |     90.86 |  0.005009 |    0.2904 |    0.1108 |
-#> |.....................|   0.01001 |    0.6082 |     1.083 |   0.06511 |
-#> |.....................|    0.7417 |    0.7091 |     1.555 |    0.9473 |
-#> |.....................|    0.6961 |     1.725 |...........|...........|
-#> |   19|     480.42060 |    0.9980 |    -1.149 |   -0.9249 |   -0.9384 |
-#> |.....................|    -1.006 |   -0.9588 |   -0.2285 |   -0.7695 |
-#> |.....................|   -0.8280 |    -1.098 |   -0.5055 |   -0.9211 |
-#> |.....................|    -1.091 |   -0.3011 |...........|...........|
-#> |    U|      480.4206 |     90.81 |    -5.349 |   -0.9029 |    -2.201 |
-#> |.....................|    -4.618 |    0.4248 |     1.098 |   0.06151 |
-#> |.....................|    0.7667 |    0.7005 |     1.611 |    0.9085 |
-#> |.....................|    0.6759 |     1.901 |...........|...........|
-#> |    X|      480.4206 |     90.81 |  0.004753 |    0.2885 |    0.1107 |
-#> |.....................|  0.009872 |    0.6046 |     1.098 |   0.06151 |
-#> |.....................|    0.7667 |    0.7005 |     1.611 |    0.9085 |
-#> |.....................|    0.6759 |     1.901 |...........|...........|
-#> |    F| Forward Diff. |    -36.54 |     1.160 |   -0.4282 |   0.02550 |
-#> |.....................|    0.4248 |    0.7330 |     2.572 |     4.769 |
-#> |.....................|    -1.047 |    -1.982 |     1.244 |    -3.305 |
-#> |.....................|    -1.792 |    -2.494 |...........|...........|
-#> |   20|     480.52888 |     1.003 |    -1.232 |   -0.9300 |   -0.9345 |
-#> |.....................|    -1.037 |    -1.013 |   -0.2660 |   -0.9542 |
-#> |.....................|   -0.7770 |    -1.021 |   -0.6177 |   -0.7306 |
-#> |.....................|    -1.035 |   -0.1927 |...........|...........|
-#> |    U|     480.52888 |     91.28 |    -5.432 |   -0.9075 |    -2.197 |
-#> |.....................|    -4.649 |    0.3997 |     1.083 |   0.05616 |
-#> |.....................|    0.8040 |    0.7699 |     1.479 |     1.091 |
-#> |.....................|    0.7247 |     2.033 |...........|...........|
-#> |    X|     480.52888 |     91.28 |  0.004374 |    0.2875 |    0.1111 |
-#> |.....................|  0.009571 |    0.5986 |     1.083 |   0.05616 |
-#> |.....................|    0.8040 |    0.7699 |     1.479 |     1.091 |
-#> |.....................|    0.7247 |     2.033 |...........|...........|
-#> |   21|     479.69850 |     1.004 |    -1.189 |   -0.9273 |   -0.9365 |
-#> |.....................|    -1.020 |   -0.9850 |   -0.2467 |   -0.8583 |
-#> |.....................|   -0.8035 |    -1.061 |   -0.5593 |   -0.8297 |
-#> |.....................|    -1.064 |   -0.2490 |...........|...........|
-#> |    U|      479.6985 |     91.34 |    -5.389 |   -0.9050 |    -2.199 |
-#> |.....................|    -4.633 |    0.4128 |     1.091 |   0.05894 |
-#> |.....................|    0.7846 |    0.7338 |     1.548 |    0.9959 |
-#> |.....................|    0.6994 |     1.964 |...........|...........|
-#> |    X|      479.6985 |     91.34 |  0.004567 |    0.2880 |    0.1109 |
-#> |.....................|  0.009727 |    0.6018 |     1.091 |   0.05894 |
-#> |.....................|    0.7846 |    0.7338 |     1.548 |    0.9959 |
-#> |.....................|    0.6994 |     1.964 |...........|...........|
-#> |    F| Forward Diff. |     5.264 |     1.163 |  -0.05494 |  -0.06753 |
-#> |.....................|    0.3641 |    0.6248 |    0.1998 |     1.877 |
-#> |.....................|   -0.5696 |    0.3809 |    0.8989 |     3.758 |
-#> |.....................|    0.2123 |    -1.578 |...........|...........|
-#> |   22|     479.87893 |     1.001 |    -1.256 |   -0.9150 |   -0.9312 |
-#> |.....................|    -1.045 |    -1.024 |   -0.2268 |   -0.8946 |
-#> |.....................|   -0.7799 |    -1.052 |   -0.6825 |   -0.8629 |
-#> |.....................|    -1.056 |   -0.2060 |...........|...........|
-#> |    U|     479.87893 |     91.06 |    -5.456 |   -0.8941 |    -2.194 |
-#> |.....................|    -4.658 |    0.3949 |     1.099 |   0.05789 |
-#> |.....................|    0.8019 |    0.7416 |     1.402 |    0.9642 |
-#> |.....................|    0.7063 |     2.016 |...........|...........|
-#> |    X|     479.87893 |     91.06 |  0.004269 |    0.2903 |    0.1115 |
-#> |.....................|  0.009490 |    0.5975 |     1.099 |   0.05789 |
-#> |.....................|    0.8019 |    0.7416 |     1.402 |    0.9642 |
-#> |.....................|    0.7063 |     2.016 |...........|...........|
-#> |   23|     479.70356 |    0.9996 |    -1.214 |   -0.9229 |   -0.9346 |
-#> |.....................|    -1.029 |   -0.9992 |   -0.2397 |   -0.8723 |
-#> |.....................|   -0.7947 |    -1.058 |   -0.6038 |   -0.8437 |
-#> |.....................|    -1.061 |   -0.2328 |...........|...........|
-#> |    U|     479.70356 |     90.96 |    -5.414 |   -0.9011 |    -2.197 |
-#> |.....................|    -4.642 |    0.4062 |     1.093 |   0.05853 |
-#> |.....................|    0.7910 |    0.7364 |     1.495 |    0.9825 |
-#> |.....................|    0.7017 |     1.984 |...........|...........|
-#> |    X|     479.70356 |     90.96 |  0.004455 |    0.2888 |    0.1111 |
-#> |.....................|  0.009639 |    0.6002 |     1.093 |   0.05853 |
-#> |.....................|    0.7910 |    0.7364 |     1.495 |    0.9825 |
-#> |.....................|    0.7017 |     1.984 |...........|...........|
-#> |   24|     479.71523 |    0.9993 |    -1.201 |   -0.9253 |   -0.9356 |
-#> |.....................|    -1.025 |   -0.9918 |   -0.2436 |   -0.8656 |
-#> |.....................|   -0.7992 |    -1.060 |   -0.5801 |   -0.8379 |
-#> |.....................|    -1.063 |   -0.2408 |...........|...........|
-#> |    U|     479.71523 |     90.93 |    -5.401 |   -0.9032 |    -2.198 |
-#> |.....................|    -4.637 |    0.4096 |     1.092 |   0.05873 |
-#> |.....................|    0.7877 |    0.7349 |     1.523 |    0.9880 |
-#> |.....................|    0.7004 |     1.974 |...........|...........|
-#> |    X|     479.71523 |     90.93 |  0.004513 |    0.2884 |    0.1110 |
-#> |.....................|  0.009685 |    0.6010 |     1.092 |   0.05873 |
-#> |.....................|    0.7877 |    0.7349 |     1.523 |    0.9880 |
-#> |.....................|    0.7004 |     1.974 |...........|...........|
-#> |   25|     479.73471 |    0.9991 |    -1.194 |   -0.9266 |   -0.9362 |
-#> |.....................|    -1.022 |   -0.9877 |   -0.2457 |   -0.8619 |
-#> |.....................|   -0.8017 |    -1.061 |   -0.5670 |   -0.8347 |
-#> |.....................|    -1.064 |   -0.2453 |...........|...........|
-#> |    U|     479.73471 |     90.92 |    -5.394 |   -0.9044 |    -2.199 |
-#> |.....................|    -4.635 |    0.4115 |     1.091 |   0.05884 |
-#> |.....................|    0.7859 |    0.7340 |     1.539 |    0.9911 |
-#> |.....................|    0.6996 |     1.969 |...........|...........|
-#> |    X|     479.73471 |     90.92 |  0.004545 |    0.2881 |    0.1110 |
-#> |.....................|  0.009710 |    0.6015 |     1.091 |   0.05884 |
-#> |.....................|    0.7859 |    0.7340 |     1.539 |    0.9911 |
-#> |.....................|    0.6996 |     1.969 |...........|...........|
-#> |   26|     479.71271 |     1.001 |    -1.190 |   -0.9273 |   -0.9365 |
-#> |.....................|    -1.021 |   -0.9854 |   -0.2468 |   -0.8594 |
-#> |.....................|   -0.8032 |    -1.061 |   -0.5599 |   -0.8320 |
-#> |.....................|    -1.064 |   -0.2481 |...........|...........|
-#> |    U|     479.71271 |     91.05 |    -5.390 |   -0.9050 |    -2.199 |
-#> |.....................|    -4.633 |    0.4126 |     1.091 |   0.05891 |
-#> |.....................|    0.7849 |    0.7336 |     1.547 |    0.9937 |
-#> |.....................|    0.6993 |     1.965 |...........|...........|
-#> |    X|     479.71271 |     91.05 |  0.004564 |    0.2880 |    0.1109 |
-#> |.....................|  0.009725 |    0.6017 |     1.091 |   0.05891 |
-#> |.....................|    0.7849 |    0.7336 |     1.547 |    0.9937 |
-#> |.....................|    0.6993 |     1.965 |...........|...........|
-#> |   27|     479.69386 |     1.003 |    -1.189 |   -0.9273 |   -0.9365 |
-#> |.....................|    -1.020 |   -0.9851 |   -0.2467 |   -0.8587 |
-#> |.....................|   -0.8034 |    -1.061 |   -0.5595 |   -0.8305 |
-#> |.....................|    -1.064 |   -0.2487 |...........|...........|
-#> |    U|     479.69386 |     91.24 |    -5.389 |   -0.9050 |    -2.199 |
-#> |.....................|    -4.633 |    0.4127 |     1.091 |   0.05893 |
-#> |.....................|    0.7847 |    0.7338 |     1.548 |    0.9951 |
-#> |.....................|    0.6994 |     1.965 |...........|...........|
-#> |    X|     479.69386 |     91.24 |  0.004566 |    0.2880 |    0.1109 |
-#> |.....................|  0.009726 |    0.6017 |     1.091 |   0.05893 |
-#> |.....................|    0.7847 |    0.7338 |     1.548 |    0.9951 |
-#> |.....................|    0.6994 |     1.965 |...........|...........|
-#> |    F| Forward Diff. |    -3.722 |     1.155 |   -0.1645 |  -0.05121 |
-#> |.....................|    0.3669 |    0.6376 |   0.06785 |     1.772 |
-#> |.....................|   -0.5854 |    0.2936 |    0.9229 |     3.709 |
-#> |.....................|    0.2520 |    -1.579 |...........|...........|
-#> |   28|     479.68901 |     1.004 |    -1.189 |   -0.9273 |   -0.9365 |
-#> |.....................|    -1.021 |   -0.9853 |   -0.2467 |   -0.8591 |
-#> |.....................|   -0.8033 |    -1.061 |   -0.5597 |   -0.8314 |
-#> |.....................|    -1.064 |   -0.2483 |...........|...........|
-#> |    U|     479.68901 |     91.32 |    -5.389 |   -0.9050 |    -2.199 |
-#> |.....................|    -4.633 |    0.4126 |     1.091 |   0.05892 |
-#> |.....................|    0.7848 |    0.7337 |     1.547 |    0.9942 |
-#> |.....................|    0.6993 |     1.965 |...........|...........|
-#> |    X|     479.68901 |     91.32 |  0.004565 |    0.2880 |    0.1109 |
-#> |.....................|  0.009725 |    0.6017 |     1.091 |   0.05892 |
-#> |.....................|    0.7848 |    0.7337 |     1.547 |    0.9942 |
-#> |.....................|    0.6993 |     1.965 |...........|...........|
-#> |    F| Forward Diff. |     3.772 |     1.160 |  -0.07003 |  -0.06455 |
-#> |.....................|    0.3646 |    0.6238 |   0.08418 |     1.806 |
-#> |.....................|   -0.5672 |    0.3711 |    0.9250 |     3.651 |
-#> |.....................|    0.2161 |    -1.579 |...........|...........|
-#> |   29|     479.68474 |     1.003 |    -1.190 |   -0.9272 |   -0.9365 |
-#> |.....................|    -1.021 |   -0.9854 |   -0.2468 |   -0.8595 |
-#> |.....................|   -0.8031 |    -1.061 |   -0.5600 |   -0.8323 |
-#> |.....................|    -1.064 |   -0.2479 |...........|...........|
-#> |    U|     479.68474 |     91.24 |    -5.390 |   -0.9050 |    -2.199 |
-#> |.....................|    -4.633 |    0.4126 |     1.091 |   0.05890 |
-#> |.....................|    0.7849 |    0.7336 |     1.547 |    0.9934 |
-#> |.....................|    0.6993 |     1.966 |...........|...........|
-#> |    X|     479.68474 |     91.24 |  0.004563 |    0.2880 |    0.1109 |
-#> |.....................|  0.009724 |    0.6017 |     1.091 |   0.05890 |
-#> |.....................|    0.7849 |    0.7336 |     1.547 |    0.9934 |
-#> |.....................|    0.6993 |     1.966 |...........|...........|
-#> |    F| Forward Diff. |    -3.834 |     1.153 |   -0.1599 |  -0.05010 |
-#> |.....................|    0.3669 |    0.6355 |   0.09191 |     1.764 |
-#> |.....................|   -0.5796 |    0.2889 |     1.006 |     3.561 |
-#> |.....................|    0.2610 |    -1.565 |...........|...........|
-#> |   30|     479.68016 |     1.004 |    -1.190 |   -0.9272 |   -0.9365 |
-#> |.....................|    -1.021 |   -0.9856 |   -0.2468 |   -0.8600 |
-#> |.....................|   -0.8030 |    -1.061 |   -0.5602 |   -0.8332 |
-#> |.....................|    -1.064 |   -0.2475 |...........|...........|
-#> |    U|     479.68016 |     91.32 |    -5.390 |   -0.9050 |    -2.199 |
-#> |.....................|    -4.633 |    0.4125 |     1.091 |   0.05889 |
-#> |.....................|    0.7850 |    0.7336 |     1.547 |    0.9926 |
-#> |.....................|    0.6992 |     1.966 |...........|...........|
-#> |    X|     479.68016 |     91.32 |  0.004562 |    0.2880 |    0.1109 |
-#> |.....................|  0.009723 |    0.6017 |     1.091 |   0.05889 |
-#> |.....................|    0.7850 |    0.7336 |     1.547 |    0.9926 |
-#> |.....................|    0.6992 |     1.966 |...........|...........|
-#> |    F| Forward Diff. |     3.891 |     1.158 |  -0.06530 |  -0.06447 |
-#> |.....................|    0.3645 |    0.6207 |    0.1821 |     1.812 |
-#> |.....................|   -0.5486 |    0.3656 |     1.002 |     3.562 |
-#> |.....................|    0.2233 |    -1.574 |...........|...........|
-#> |   31|     479.67614 |     1.003 |    -1.190 |   -0.9272 |   -0.9365 |
-#> |.....................|    -1.021 |   -0.9857 |   -0.2468 |   -0.8604 |
-#> |.....................|   -0.8028 |    -1.061 |   -0.5604 |   -0.8341 |
-#> |.....................|    -1.064 |   -0.2472 |...........|...........|
-#> |    U|     479.67614 |     91.24 |    -5.390 |   -0.9049 |    -2.199 |
-#> |.....................|    -4.633 |    0.4124 |     1.091 |   0.05888 |
-#> |.....................|    0.7851 |    0.7335 |     1.546 |    0.9917 |
-#> |.....................|    0.6992 |     1.966 |...........|...........|
-#> |    X|     479.67614 |     91.24 |  0.004561 |    0.2880 |    0.1109 |
-#> |.....................|  0.009722 |    0.6017 |     1.091 |   0.05888 |
-#> |.....................|    0.7851 |    0.7335 |     1.546 |    0.9917 |
-#> |.....................|    0.6992 |     1.966 |...........|...........|
-#> |    F| Forward Diff. |    -3.915 |     1.151 |   -0.1574 |  -0.04977 |
-#> |.....................|    0.3672 |    0.6321 |   0.06058 |     1.705 |
-#> |.....................|   -0.5691 |    0.2601 |    0.8724 |     3.420 |
-#> |.....................|    0.2638 |    -1.562 |...........|...........|
-#> |   32|     479.67180 |     1.004 |    -1.191 |   -0.9271 |   -0.9364 |
-#> |.....................|    -1.021 |   -0.9859 |   -0.2469 |   -0.8608 |
-#> |.....................|   -0.8027 |    -1.061 |   -0.5607 |   -0.8349 |
-#> |.....................|    -1.064 |   -0.2468 |...........|...........|
-#> |    U|      479.6718 |     91.33 |    -5.391 |   -0.9049 |    -2.199 |
-#> |.....................|    -4.633 |    0.4124 |     1.091 |   0.05887 |
-#> |.....................|    0.7852 |    0.7334 |     1.546 |    0.9909 |
-#> |.....................|    0.6991 |     1.967 |...........|...........|
-#> |    X|      479.6718 |     91.33 |  0.004560 |    0.2880 |    0.1109 |
-#> |.....................|  0.009722 |    0.6017 |     1.091 |   0.05887 |
-#> |.....................|    0.7852 |    0.7334 |     1.546 |    0.9909 |
-#> |.....................|    0.6991 |     1.967 |...........|...........|
-#> |    F| Forward Diff. |     4.074 |     1.157 |  -0.05990 |  -0.06452 |
-#> |.....................|    0.3645 |    0.6170 |    0.1286 |     1.744 |
-#> |.....................|   -0.5576 |    0.3161 |    0.9007 |     3.345 |
-#> |.....................|    0.2216 |    -1.572 |...........|...........|
-#> |   33|     479.66809 |     1.003 |    -1.191 |   -0.9271 |   -0.9364 |
-#> |.....................|    -1.021 |   -0.9860 |   -0.2469 |   -0.8613 |
-#> |.....................|   -0.8026 |    -1.062 |   -0.5609 |   -0.8357 |
-#> |.....................|    -1.064 |   -0.2464 |...........|...........|
-#> |    U|     479.66809 |     91.23 |    -5.391 |   -0.9049 |    -2.199 |
-#> |.....................|    -4.634 |    0.4123 |     1.091 |   0.05885 |
-#> |.....................|    0.7853 |    0.7334 |     1.546 |    0.9901 |
-#> |.....................|    0.6991 |     1.967 |...........|...........|
-#> |    X|     479.66809 |     91.23 |  0.004558 |    0.2880 |    0.1109 |
-#> |.....................|  0.009721 |    0.6016 |     1.091 |   0.05885 |
-#> |.....................|    0.7853 |    0.7334 |     1.546 |    0.9901 |
-#> |.....................|    0.6991 |     1.967 |...........|...........|
-#> |    F| Forward Diff. |    -4.161 |     1.149 |   -0.1570 |  -0.04911 |
-#> |.....................|    0.3674 |    0.6293 |   0.04215 |     1.668 |
-#> |.....................|   -0.5621 |    0.2625 |    0.8940 |     3.313 |
-#> |.....................|    0.2611 |    -1.561 |...........|...........|
-#> |   34|     479.66397 |     1.004 |    -1.191 |   -0.9271 |   -0.9364 |
-#> |.....................|    -1.021 |   -0.9862 |   -0.2469 |   -0.8617 |
-#> |.....................|   -0.8024 |    -1.062 |   -0.5611 |   -0.8366 |
-#> |.....................|    -1.064 |   -0.2460 |...........|...........|
-#> |    U|     479.66397 |     91.33 |    -5.391 |   -0.9049 |    -2.199 |
-#> |.....................|    -4.634 |    0.4122 |     1.091 |   0.05884 |
-#> |.....................|    0.7854 |    0.7333 |     1.546 |    0.9893 |
-#> |.....................|    0.6990 |     1.968 |...........|...........|
-#> |    X|     479.66397 |     91.33 |  0.004557 |    0.2881 |    0.1109 |
-#> |.....................|  0.009720 |    0.6016 |     1.091 |   0.05884 |
-#> |.....................|    0.7854 |    0.7333 |     1.546 |    0.9893 |
-#> |.....................|    0.6990 |     1.968 |...........|...........|
-#> |    F| Forward Diff. |     4.197 |     1.155 |  -0.05534 |  -0.06448 |
-#> |.....................|    0.3644 |    0.6140 |    0.1526 |     1.765 |
-#> |.....................|   -0.5340 |    0.3555 |    0.9900 |     3.325 |
-#> |.....................|    0.2199 |    -1.571 |...........|...........|
-#> |   35|     479.66043 |     1.003 |    -1.191 |   -0.9271 |   -0.9364 |
-#> |.....................|    -1.021 |   -0.9863 |   -0.2469 |   -0.8621 |
-#> |.....................|   -0.8023 |    -1.062 |   -0.5613 |   -0.8374 |
-#> |.....................|    -1.064 |   -0.2456 |...........|...........|
-#> |    U|     479.66043 |     91.23 |    -5.391 |   -0.9048 |    -2.199 |
-#> |.....................|    -4.634 |    0.4122 |     1.090 |   0.05883 |
-#> |.....................|    0.7855 |    0.7332 |     1.545 |    0.9886 |
-#> |.....................|    0.6989 |     1.968 |...........|...........|
-#> |    X|     479.66043 |     91.23 |  0.004556 |    0.2881 |    0.1109 |
-#> |.....................|  0.009719 |    0.6016 |     1.090 |   0.05883 |
-#> |.....................|    0.7855 |    0.7332 |     1.545 |    0.9886 |
-#> |.....................|    0.6989 |     1.968 |...........|...........|
-#> |    F| Forward Diff. |    -4.161 |     1.147 |   -0.1538 |  -0.04891 |
-#> |.....................|    0.3674 |    0.6262 |   0.06581 |     1.677 |
-#> |.....................|   -0.5453 |    0.2828 |     1.029 |     3.251 |
-#> |.....................|    0.2683 |    -1.555 |...........|...........|
-#> |   36|     479.65652 |     1.004 |    -1.192 |   -0.9270 |   -0.9364 |
-#> |.....................|    -1.021 |   -0.9865 |   -0.2469 |   -0.8625 |
-#> |.....................|   -0.8022 |    -1.062 |   -0.5616 |   -0.8382 |
-#> |.....................|    -1.064 |   -0.2452 |...........|...........|
-#> |    U|     479.65652 |     91.33 |    -5.392 |   -0.9048 |    -2.199 |
-#> |.....................|    -4.634 |    0.4121 |     1.090 |   0.05882 |
-#> |.....................|    0.7856 |    0.7332 |     1.545 |    0.9878 |
-#> |.....................|    0.6989 |     1.969 |...........|...........|
-#> |    X|     479.65652 |     91.33 |  0.004554 |    0.2881 |    0.1109 |
-#> |.....................|  0.009718 |    0.6016 |     1.090 |   0.05882 |
-#> |.....................|    0.7856 |    0.7332 |     1.545 |    0.9878 |
-#> |.....................|    0.6989 |     1.969 |...........|...........|
-#> |    F| Forward Diff. |     4.221 |     1.153 |  -0.05203 |  -0.06424 |
-#> |.....................|    0.3643 |    0.6104 |   0.04854 |     1.680 |
-#> |.....................|   -0.5365 |    0.2999 |    0.7877 |     3.080 |
-#> |.....................|    0.2284 |    -1.566 |...........|...........|
-#> |   37|     479.65328 |     1.003 |    -1.192 |   -0.9270 |   -0.9364 |
-#> |.....................|    -1.021 |   -0.9866 |   -0.2470 |   -0.8629 |
-#> |.....................|   -0.8020 |    -1.062 |   -0.5618 |   -0.8389 |
-#> |.....................|    -1.064 |   -0.2448 |...........|...........|
-#> |    U|     479.65328 |     91.23 |    -5.392 |   -0.9048 |    -2.199 |
-#> |.....................|    -4.634 |    0.4120 |     1.090 |   0.05880 |
-#> |.....................|    0.7857 |    0.7331 |     1.545 |    0.9871 |
-#> |.....................|    0.6988 |     1.969 |...........|...........|
-#> |    X|     479.65328 |     91.23 |  0.004553 |    0.2881 |    0.1109 |
-#> |.....................|  0.009717 |    0.6016 |     1.090 |   0.05880 |
-#> |.....................|    0.7857 |    0.7331 |     1.545 |    0.9871 |
-#> |.....................|    0.6988 |     1.969 |...........|...........|
-#> |    F| Forward Diff. |    -4.438 |     1.145 |   -0.1538 |  -0.04822 |
-#> |.....................|    0.3675 |    0.6235 | 0.0004265 |     1.625 |
-#> |.....................|   -0.5487 |    0.2329 |    0.8499 |     3.058 |
-#> |.....................|    0.2658 |    -1.554 |...........|...........|
-#> |   38|     479.64923 |     1.004 |    -1.192 |   -0.9270 |   -0.9364 |
-#> |.....................|    -1.022 |   -0.9868 |   -0.2469 |   -0.8633 |
-#> |.....................|   -0.8019 |    -1.062 |   -0.5621 |   -0.8396 |
-#> |.....................|    -1.065 |   -0.2444 |...........|...........|
-#> |    U|     479.64923 |     91.32 |    -5.392 |   -0.9048 |    -2.199 |
-#> |.....................|    -4.634 |    0.4119 |     1.091 |   0.05879 |
-#> |.....................|    0.7858 |    0.7330 |     1.544 |    0.9864 |
-#> |.....................|    0.6988 |     1.970 |...........|...........|
-#> |    X|     479.64923 |     91.32 |  0.004551 |    0.2881 |    0.1109 |
-#> |.....................|  0.009716 |    0.6015 |     1.091 |   0.05879 |
-#> |.....................|    0.7858 |    0.7330 |     1.544 |    0.9864 |
-#> |.....................|    0.6988 |     1.970 |...........|...........|
-#> |    F| Forward Diff. |     3.878 |     1.150 |  -0.05277 |  -0.06333 |
-#> |.....................|    0.3643 |    0.6074 |   0.07271 |     1.651 |
-#> |.....................|   -0.5369 |    0.2992 |    0.8896 |     2.970 |
-#> |.....................|    0.2314 |    -1.562 |...........|...........|
-#> |   39|     479.64621 |     1.003 |    -1.193 |   -0.9270 |   -0.9363 |
-#> |.....................|    -1.022 |   -0.9870 |   -0.2469 |   -0.8638 |
-#> |.....................|   -0.8017 |    -1.062 |   -0.5623 |   -0.8404 |
-#> |.....................|    -1.065 |   -0.2440 |...........|...........|
-#> |    U|     479.64621 |     91.23 |    -5.393 |   -0.9047 |    -2.199 |
-#> |.....................|    -4.634 |    0.4119 |     1.091 |   0.05878 |
-#> |.....................|    0.7859 |    0.7330 |     1.544 |    0.9856 |
-#> |.....................|    0.6987 |     1.970 |...........|...........|
-#> |    X|     479.64621 |     91.23 |  0.004550 |    0.2881 |    0.1109 |
-#> |.....................|  0.009715 |    0.6015 |     1.091 |   0.05878 |
-#> |.....................|    0.7859 |    0.7330 |     1.544 |    0.9856 |
-#> |.....................|    0.6987 |     1.970 |...........|...........|
-#> |    F| Forward Diff. |    -4.471 |     1.143 |   -0.1506 |  -0.04802 |
-#> |.....................|    0.3674 |    0.6203 | -0.003354 |     1.603 |
-#> |.....................|   -0.5429 |    0.2243 |    0.9025 |     2.920 |
-#> |.....................|    0.2732 |    -1.548 |...........|...........|
-#> |   40|     479.64228 |     1.004 |    -1.193 |   -0.9269 |   -0.9363 |
-#> |.....................|    -1.022 |   -0.9872 |   -0.2468 |   -0.8642 |
-#> |.....................|   -0.8016 |    -1.062 |   -0.5627 |   -0.8411 |
-#> |.....................|    -1.065 |   -0.2435 |...........|...........|
-#> |    U|     479.64228 |     91.32 |    -5.393 |   -0.9047 |    -2.199 |
-#> |.....................|    -4.634 |    0.4118 |     1.091 |   0.05877 |
-#> |.....................|    0.7860 |    0.7329 |     1.544 |    0.9850 |
-#> |.....................|    0.6987 |     1.971 |...........|...........|
-#> |    X|     479.64228 |     91.32 |  0.004548 |    0.2881 |    0.1109 |
-#> |.....................|  0.009714 |    0.6015 |     1.091 |   0.05877 |
-#> |.....................|    0.7860 |    0.7329 |     1.544 |    0.9850 |
-#> |.....................|    0.6987 |     1.971 |...........|...........|
-#> |    F| Forward Diff. |     3.744 |     1.148 |  -0.05088 |  -0.06289 |
-#> |.....................|    0.3642 |    0.6037 |   0.03047 |     1.629 |
-#> |.....................|   -0.5287 |    0.2733 |    0.8334 |     2.850 |
-#> |.....................|    0.2290 |    -1.558 |...........|...........|
-#> |   41|     479.63935 |     1.003 |    -1.193 |   -0.9269 |   -0.9363 |
-#> |.....................|    -1.022 |   -0.9874 |   -0.2468 |   -0.8646 |
-#> |.....................|   -0.8014 |    -1.062 |   -0.5630 |   -0.8419 |
-#> |.....................|    -1.065 |   -0.2431 |...........|...........|
-#> |    U|     479.63935 |     91.23 |    -5.393 |   -0.9047 |    -2.199 |
-#> |.....................|    -4.634 |    0.4117 |     1.091 |   0.05876 |
-#> |.....................|    0.7861 |    0.7329 |     1.543 |    0.9843 |
-#> |.....................|    0.6986 |     1.971 |...........|...........|
-#> |    X|     479.63935 |     91.23 |  0.004547 |    0.2881 |    0.1110 |
-#> |.....................|  0.009713 |    0.6015 |     1.091 |   0.05876 |
-#> |.....................|    0.7861 |    0.7329 |     1.543 |    0.9843 |
-#> |.....................|    0.6986 |     1.971 |...........|...........|
-#> |    F| Forward Diff. |    -4.432 |     1.140 |   -0.1464 |  -0.04798 |
-#> |.....................|    0.3672 |    0.6157 |  -0.06295 |     1.547 |
-#> |.....................|   -0.5341 |    0.1919 |    0.7582 |     2.801 |
-#> |.....................|    0.2698 |    -1.544 |...........|...........|
-#> |   42|     479.63543 |     1.004 |    -1.194 |   -0.9268 |   -0.9363 |
-#> |.....................|    -1.022 |   -0.9876 |   -0.2467 |   -0.8650 |
-#> |.....................|   -0.8013 |    -1.062 |   -0.5633 |   -0.8425 |
-#> |.....................|    -1.065 |   -0.2426 |...........|...........|
-#> |    U|     479.63543 |     91.32 |    -5.394 |   -0.9046 |    -2.199 |
-#> |.....................|    -4.634 |    0.4116 |     1.091 |   0.05874 |
-#> |.....................|    0.7863 |    0.7328 |     1.543 |    0.9837 |
-#> |.....................|    0.6985 |     1.972 |...........|...........|
-#> |    X|     479.63543 |     91.32 |  0.004545 |    0.2881 |    0.1110 |
-#> |.....................|  0.009712 |    0.6015 |     1.091 |   0.05874 |
-#> |.....................|    0.7863 |    0.7328 |     1.543 |    0.9837 |
-#> |.....................|    0.6985 |     1.972 |...........|...........|
-#> |    F| Forward Diff. |     3.612 |     1.146 |  -0.04876 |  -0.06242 |
-#> |.....................|    0.3640 |    0.6002 |   0.04743 |     1.619 |
-#> |.....................|   -0.5199 |    0.2573 |    0.7734 |     2.739 |
-#> |.....................|    0.2298 |    -1.553 |...........|...........|
-#> |   43|     479.63248 |     1.003 |    -1.194 |   -0.9268 |   -0.9363 |
-#> |.....................|    -1.022 |   -0.9878 |   -0.2466 |   -0.8655 |
-#> |.....................|   -0.8011 |    -1.062 |   -0.5636 |   -0.8432 |
-#> |.....................|    -1.065 |   -0.2421 |...........|...........|
-#> |    U|     479.63248 |     91.23 |    -5.394 |   -0.9046 |    -2.199 |
-#> |.....................|    -4.635 |    0.4115 |     1.091 |   0.05873 |
-#> |.....................|    0.7864 |    0.7328 |     1.543 |    0.9830 |
-#> |.....................|    0.6985 |     1.973 |...........|...........|
-#> |    X|     479.63248 |     91.23 |  0.004543 |    0.2881 |    0.1110 |
-#> |.....................|  0.009710 |    0.6014 |     1.091 |   0.05873 |
-#> |.....................|    0.7864 |    0.7328 |     1.543 |    0.9830 |
-#> |.....................|    0.6985 |     1.973 |...........|...........|
-#> |    F| Forward Diff. |    -4.237 |     1.138 |   -0.1400 |  -0.04830 |
-#> |.....................|    0.3668 |    0.6108 |  -0.07665 |     1.521 |
-#> |.....................|   -0.5353 |    0.1893 |    0.7456 |     2.704 |
-#> |.....................|    0.2668 |    -1.543 |...........|...........|
-#> |   44|     479.62869 |     1.004 |    -1.195 |   -0.9268 |   -0.9362 |
-#> |.....................|    -1.022 |   -0.9880 |   -0.2464 |   -0.8659 |
-#> |.....................|   -0.8009 |    -1.062 |   -0.5639 |   -0.8438 |
-#> |.....................|    -1.065 |   -0.2415 |...........|...........|
-#> |    U|     479.62869 |     91.32 |    -5.395 |   -0.9046 |    -2.199 |
-#> |.....................|    -4.635 |    0.4114 |     1.091 |   0.05872 |
-#> |.....................|    0.7865 |    0.7327 |     1.542 |    0.9824 |
-#> |.....................|    0.6984 |     1.973 |...........|...........|
-#> |    X|     479.62869 |     91.32 |  0.004541 |    0.2881 |    0.1110 |
-#> |.....................|  0.009709 |    0.6014 |     1.091 |   0.05872 |
-#> |.....................|    0.7865 |    0.7327 |     1.542 |    0.9824 |
-#> |.....................|    0.6984 |     1.973 |...........|...........|
-#> |    F| Forward Diff. |     3.552 |     1.143 |  -0.04554 |  -0.06221 |
-#> |.....................|    0.3637 |    0.5952 |  -0.01323 |     1.563 |
-#> |.....................|   -0.3448 |    0.2470 |    0.7924 |     2.643 |
-#> |.....................|    0.2272 |    -1.550 |...........|...........|
-#> |   45|     479.62584 |     1.003 |    -1.195 |   -0.9268 |   -0.9362 |
-#> |.....................|    -1.022 |   -0.9883 |   -0.2463 |   -0.8663 |
-#> |.....................|   -0.8008 |    -1.062 |   -0.5642 |   -0.8446 |
-#> |.....................|    -1.065 |   -0.2410 |...........|...........|
-#> |    U|     479.62584 |     91.24 |    -5.395 |   -0.9046 |    -2.199 |
-#> |.....................|    -4.635 |    0.4113 |     1.091 |   0.05871 |
-#> |.....................|    0.7866 |    0.7326 |     1.542 |    0.9817 |
-#> |.....................|    0.6983 |     1.974 |...........|...........|
-#> |    X|     479.62584 |     91.24 |  0.004539 |    0.2881 |    0.1110 |
-#> |.....................|  0.009708 |    0.6014 |     1.091 |   0.05871 |
-#> |.....................|    0.7866 |    0.7326 |     1.542 |    0.9817 |
-#> |.....................|    0.6983 |     1.974 |...........|...........|
-#> |    F| Forward Diff. |    -4.148 |     1.135 |   -0.1348 |  -0.04846 |
-#> |.....................|    0.3664 |    0.6063 | -0.009834 |     1.510 |
-#> |.....................|   -0.5271 |    0.1803 |    0.7932 |     2.587 |
-#> |.....................|    0.2684 |    -1.536 |...........|...........|
-#> |   46|     479.62216 |     1.004 |    -1.195 |   -0.9267 |   -0.9362 |
-#> |.....................|    -1.023 |   -0.9885 |   -0.2462 |   -0.8667 |
-#> |.....................|   -0.8007 |    -1.062 |   -0.5646 |   -0.8451 |
-#> |.....................|    -1.065 |   -0.2404 |...........|...........|
-#> |    U|     479.62216 |     91.32 |    -5.395 |   -0.9045 |    -2.199 |
-#> |.....................|    -4.635 |    0.4112 |     1.091 |   0.05870 |
-#> |.....................|    0.7867 |    0.7326 |     1.541 |    0.9811 |
-#> |.....................|    0.6983 |     1.975 |...........|...........|
-#> |    X|     479.62216 |     91.32 |  0.004537 |    0.2881 |    0.1110 |
-#> |.....................|  0.009706 |    0.6014 |     1.091 |   0.05870 |
-#> |.....................|    0.7867 |    0.7326 |     1.541 |    0.9811 |
-#> |.....................|    0.6983 |     1.975 |...........|...........|
-#> |    F| Forward Diff. |     3.404 |     1.140 |  -0.04564 |  -0.06187 |
-#> |.....................|    0.3633 |    0.5903 |  -0.01970 |     1.541 |
-#> |.....................|   -0.5054 |    0.2303 |    0.6483 |     2.528 |
-#> |.....................|    0.2288 |    -1.542 |...........|...........|
-#> |   47|     479.61938 |     1.003 |    -1.196 |   -0.9267 |   -0.9362 |
-#> |.....................|    -1.023 |   -0.9887 |   -0.2461 |   -0.8672 |
-#> |.....................|   -0.8005 |    -1.062 |   -0.5649 |   -0.8458 |
-#> |.....................|    -1.065 |   -0.2398 |...........|...........|
-#> |    U|     479.61938 |     91.24 |    -5.396 |   -0.9045 |    -2.199 |
-#> |.....................|    -4.635 |    0.4111 |     1.091 |   0.05868 |
-#> |.....................|    0.7868 |    0.7325 |     1.541 |    0.9805 |
-#> |.....................|    0.6982 |     1.975 |...........|...........|
-#> |    X|     479.61938 |     91.24 |  0.004535 |    0.2881 |    0.1110 |
-#> |.....................|  0.009705 |    0.6013 |     1.091 |   0.05868 |
-#> |.....................|    0.7868 |    0.7325 |     1.541 |    0.9805 |
-#> |.....................|    0.6982 |     1.975 |...........|...........|
-#> |    F| Forward Diff. |    -4.197 |     1.132 |   -0.1312 |  -0.04839 |
-#> |.....................|    0.3660 |    0.6012 |   0.05916 |     1.560 |
-#> |.....................|   -0.4869 |    0.2015 |    0.8305 |     2.573 |
-#> |.....................|    0.2666 |    -1.531 |...........|...........|
-#> |   48|     479.61563 |     1.003 |    -1.196 |   -0.9266 |   -0.9361 |
-#> |.....................|    -1.023 |   -0.9890 |   -0.2459 |   -0.8676 |
-#> |.....................|   -0.8003 |    -1.062 |   -0.5653 |   -0.8464 |
-#> |.....................|    -1.065 |   -0.2392 |...........|...........|
-#> |    U|     479.61563 |     91.32 |    -5.396 |   -0.9044 |    -2.199 |
-#> |.....................|    -4.635 |    0.4109 |     1.091 |   0.05867 |
-#> |.....................|    0.7870 |    0.7325 |     1.541 |    0.9799 |
-#> |.....................|    0.6981 |     1.976 |...........|...........|
-#> |    X|     479.61563 |     91.32 |  0.004533 |    0.2881 |    0.1110 |
-#> |.....................|  0.009703 |    0.6013 |     1.091 |   0.05867 |
-#> |.....................|    0.7870 |    0.7325 |     1.541 |    0.9799 |
-#> |.....................|    0.6981 |     1.976 |...........|...........|
-#> |    F| Forward Diff. |     3.024 |     1.137 |  -0.04591 |  -0.06118 |
-#> |.....................|    0.3629 |    0.5856 |  0.004035 |     1.536 |
-#> |.....................|   -0.4978 |    0.2329 |    0.6617 |     2.436 |
-#> |.....................|    0.2318 |    -1.535 |...........|...........|
-#> |   49|     479.61337 |     1.003 |    -1.197 |   -0.9266 |   -0.9361 |
-#> |.....................|    -1.023 |   -0.9892 |   -0.2459 |   -0.8680 |
-#> |.....................|   -0.8001 |    -1.063 |   -0.5655 |   -0.8471 |
-#> |.....................|    -1.065 |   -0.2388 |...........|...........|
-#> |    U|     479.61337 |     91.23 |    -5.397 |   -0.9044 |    -2.198 |
-#> |.....................|    -4.635 |    0.4109 |     1.091 |   0.05866 |
-#> |.....................|    0.7871 |    0.7324 |     1.540 |    0.9792 |
-#> |.....................|    0.6980 |     1.977 |...........|...........|
-#> |    X|     479.61337 |     91.23 |  0.004531 |    0.2881 |    0.1110 |
-#> |.....................|  0.009702 |    0.6013 |     1.091 |   0.05866 |
-#> |.....................|    0.7871 |    0.7324 |     1.540 |    0.9792 |
-#> |.....................|    0.6980 |     1.977 |...........|...........|
-#> |    F| Forward Diff. |    -4.815 |     1.129 |   -0.1342 |  -0.04706 |
-#> |.....................|    0.3660 |    0.5971 |  -0.07697 |     1.438 |
-#> |.....................|   -0.5059 |    0.1462 |    0.6633 |     2.381 |
-#> |.....................|    0.2676 |    -1.522 |...........|...........|
-#> |   50|     479.60932 |     1.003 |    -1.197 |   -0.9266 |   -0.9361 |
-#> |.....................|    -1.023 |   -0.9894 |   -0.2456 |   -0.8684 |
-#> |.....................|   -0.8000 |    -1.063 |   -0.5659 |   -0.8476 |
-#> |.....................|    -1.066 |   -0.2381 |...........|...........|
-#> |    U|     479.60932 |     91.31 |    -5.397 |   -0.9044 |    -2.198 |
-#> |.....................|    -4.636 |    0.4107 |     1.091 |   0.05865 |
-#> |.....................|    0.7872 |    0.7324 |     1.540 |    0.9788 |
-#> |.....................|    0.6979 |     1.977 |...........|...........|
-#> |    X|     479.60932 |     91.31 |  0.004529 |    0.2882 |    0.1110 |
-#> |.....................|  0.009700 |    0.6013 |     1.091 |   0.05865 |
-#> |.....................|    0.7872 |    0.7324 |     1.540 |    0.9788 |
-#> |.....................|    0.6979 |     1.977 |...........|...........|
-#> |    F| Forward Diff. |     2.699 |     1.134 |  -0.04549 |  -0.06017 |
-#> |.....................|    0.3630 |    0.5814 |  -0.04512 |     1.484 |
-#> |.....................|   -0.4915 |    0.2556 |    0.7248 |     2.322 |
-#> |.....................|    0.2317 |    -1.529 |...........|...........|
-#> |   51|     479.60706 |     1.003 |    -1.198 |   -0.9265 |   -0.9361 |
-#> |.....................|    -1.023 |   -0.9896 |   -0.2455 |   -0.8689 |
-#> |.....................|   -0.7998 |    -1.063 |   -0.5661 |   -0.8484 |
-#> |.....................|    -1.066 |   -0.2376 |...........|...........|
-#> |    U|     479.60706 |     91.23 |    -5.398 |   -0.9044 |    -2.198 |
-#> |.....................|    -4.636 |    0.4106 |     1.091 |   0.05863 |
-#> |.....................|    0.7873 |    0.7323 |     1.540 |    0.9781 |
-#> |.....................|    0.6979 |     1.978 |...........|...........|
-#> |    X|     479.60706 |     91.23 |  0.004527 |    0.2882 |    0.1110 |
-#> |.....................|  0.009699 |    0.6012 |     1.091 |   0.05863 |
-#> |.....................|    0.7873 |    0.7323 |     1.540 |    0.9781 |
-#> |.....................|    0.6979 |     1.978 |...........|...........|
-#> |    F| Forward Diff. |    -4.618 |     1.127 |   -0.1276 |  -0.04760 |
-#> |.....................|    0.3656 |    0.5915 |  -0.08622 |     1.415 |
-#> |.....................|   -0.5531 |    0.1512 |    0.6569 |     2.298 |
-#> |.....................|    0.2620 |    -1.540 |...........|...........|
-#> |   52|     479.60314 |     1.003 |    -1.198 |   -0.9265 |   -0.9360 |
-#> |.....................|    -1.023 |   -0.9899 |   -0.2452 |   -0.8692 |
-#> |.....................|   -0.7996 |    -1.063 |   -0.5665 |   -0.8488 |
-#> |.....................|    -1.066 |   -0.2369 |...........|...........|
-#> |    U|     479.60314 |     91.31 |    -5.398 |   -0.9043 |    -2.198 |
-#> |.....................|    -4.636 |    0.4105 |     1.091 |   0.05862 |
-#> |.....................|    0.7875 |    0.7322 |     1.539 |    0.9776 |
-#> |.....................|    0.6978 |     1.979 |...........|...........|
-#> |    X|     479.60314 |     91.31 |  0.004525 |    0.2882 |    0.1110 |
-#> |.....................|  0.009698 |    0.6012 |     1.091 |   0.05862 |
-#> |.....................|    0.7875 |    0.7322 |     1.539 |    0.9776 |
-#> |.....................|    0.6978 |     1.979 |...........|...........|
-#> |    F| Forward Diff. |     2.641 |     1.131 |  -0.04213 |  -0.06002 |
-#> |.....................|    0.3627 |    0.5770 |  -0.05114 |     1.464 |
-#> |.....................|   -0.4913 |    0.1735 |    0.5980 |     2.238 |
-#> |.....................|    0.2116 |    -1.521 |...........|...........|
-#> |   53|     479.60093 |     1.003 |    -1.199 |   -0.9265 |   -0.9360 |
-#> |.....................|    -1.024 |   -0.9901 |   -0.2452 |   -0.8697 |
-#> |.....................|   -0.7994 |    -1.063 |   -0.5667 |   -0.8495 |
-#> |.....................|    -1.066 |   -0.2363 |...........|...........|
-#> |    U|     479.60093 |     91.23 |    -5.399 |   -0.9043 |    -2.198 |
-#> |.....................|    -4.636 |    0.4104 |     1.091 |   0.05861 |
-#> |.....................|    0.7876 |    0.7322 |     1.539 |    0.9769 |
-#> |.....................|    0.6977 |     1.980 |...........|...........|
-#> |    X|     479.60093 |     91.23 |  0.004523 |    0.2882 |    0.1110 |
-#> |.....................|  0.009696 |    0.6012 |     1.091 |   0.05861 |
-#> |.....................|    0.7876 |    0.7322 |     1.539 |    0.9769 |
-#> |.....................|    0.6977 |     1.980 |...........|...........|
-#> |    F| Forward Diff. |    -4.657 |     1.124 |   -0.1240 |  -0.04721 |
-#> |.....................|    0.3655 |    0.5872 |  -0.09119 |     1.382 |
-#> |.....................|   -0.4948 |    0.1646 |    0.6965 |     2.186 |
-#> |.....................|    0.2747 |    -1.512 |...........|...........|
-#> |   54|     479.59701 |     1.003 |    -1.199 |   -0.9264 |   -0.9360 |
-#> |.....................|    -1.024 |   -0.9904 |   -0.2448 |   -0.8700 |
-#> |.....................|   -0.7992 |    -1.063 |   -0.5670 |   -0.8499 |
-#> |.....................|    -1.066 |   -0.2356 |...........|...........|
-#> |    U|     479.59701 |     91.31 |    -5.399 |   -0.9043 |    -2.198 |
-#> |.....................|    -4.636 |    0.4103 |     1.091 |   0.05860 |
-#> |.....................|    0.7877 |    0.7321 |     1.539 |    0.9766 |
-#> |.....................|    0.6976 |     1.980 |...........|...........|
-#> |    X|     479.59701 |     91.31 |  0.004520 |    0.2882 |    0.1110 |
-#> |.....................|  0.009695 |    0.6012 |     1.091 |   0.05860 |
-#> |.....................|    0.7877 |    0.7321 |     1.539 |    0.9766 |
-#> |.....................|    0.6976 |     1.980 |...........|...........|
-#> |    F| Forward Diff. |     2.447 |     1.128 |  -0.03826 |  -0.05934 |
-#> |.....................|    0.3628 |    0.5721 |  -0.04376 |     1.440 |
-#> |.....................|   -0.4844 |    0.2233 |   -0.3355 |     1.410 |
-#> |.....................|   -0.3677 |    -1.539 |...........|...........|
-#> |   55|     479.59436 |     1.003 |    -1.200 |   -0.9264 |   -0.9360 |
-#> |.....................|    -1.024 |   -0.9907 |   -0.2446 |   -0.8705 |
-#> |.....................|   -0.7990 |    -1.063 |   -0.5669 |   -0.8504 |
-#> |.....................|    -1.066 |   -0.2349 |...........|...........|
-#> |    U|     479.59436 |     91.23 |    -5.400 |   -0.9042 |    -2.198 |
-#> |.....................|    -4.636 |    0.4102 |     1.091 |   0.05858 |
-#> |.....................|    0.7879 |    0.7320 |     1.539 |    0.9761 |
-#> |.....................|    0.6977 |     1.981 |...........|...........|
-#> |    X|     479.59436 |     91.23 |  0.004518 |    0.2882 |    0.1110 |
-#> |.....................|  0.009693 |    0.6011 |     1.091 |   0.05858 |
-#> |.....................|    0.7879 |    0.7320 |     1.539 |    0.9761 |
-#> |.....................|    0.6977 |     1.981 |...........|...........|
-#> |    F| Forward Diff. |    -4.478 |     1.121 |   -0.1165 |  -0.04761 |
-#> |.....................|    0.3651 |    0.5835 |  -0.09604 |     1.373 |
-#> |.....................|   -0.4943 |    0.1086 |   -0.4551 |     1.395 |
-#> |.....................|   -0.3088 |    -1.502 |...........|...........|
-#> |   56|     479.58979 |     1.003 |    -1.200 |   -0.9263 |   -0.9359 |
-#> |.....................|    -1.024 |   -0.9910 |   -0.2442 |   -0.8708 |
-#> |.....................|   -0.7988 |    -1.063 |   -0.5665 |   -0.8506 |
-#> |.....................|    -1.066 |   -0.2341 |...........|...........|
-#> |    U|     479.58979 |     91.30 |    -5.400 |   -0.9042 |    -2.198 |
-#> |.....................|    -4.637 |    0.4100 |     1.092 |   0.05858 |
-#> |.....................|    0.7880 |    0.7319 |     1.539 |    0.9759 |
-#> |.....................|    0.6978 |     1.982 |...........|...........|
-#> |    X|     479.58979 |     91.30 |  0.004516 |    0.2882 |    0.1110 |
-#> |.....................|  0.009691 |    0.6011 |     1.092 |   0.05858 |
-#> |.....................|    0.7880 |    0.7319 |     1.539 |    0.9759 |
-#> |.....................|    0.6978 |     1.982 |...........|...........|
-#> |    F| Forward Diff. |     1.813 |     1.125 |  -0.03904 |  -0.05862 |
-#> |.....................|    0.3624 |    0.5728 | -0.008587 |     1.448 |
-#> |.....................|   -0.2657 |    0.1639 |    0.6610 |     2.108 |
-#> |.....................|    0.2622 |    -1.501 |...........|...........|
-#> |   57|     479.58727 |     1.003 |    -1.201 |   -0.9263 |   -0.9359 |
-#> |.....................|    -1.024 |   -0.9912 |   -0.2441 |   -0.8713 |
-#> |.....................|   -0.7987 |    -1.063 |   -0.5668 |   -0.8514 |
-#> |.....................|    -1.066 |   -0.2335 |...........|...........|
-#> |    U|     479.58727 |     91.24 |    -5.401 |   -0.9042 |    -2.198 |
-#> |.....................|    -4.637 |    0.4099 |     1.092 |   0.05856 |
-#> |.....................|    0.7881 |    0.7318 |     1.539 |    0.9751 |
-#> |.....................|    0.6978 |     1.983 |...........|...........|
-#> |    X|     479.58727 |     91.24 |  0.004513 |    0.2882 |    0.1110 |
-#> |.....................|  0.009690 |    0.6011 |     1.092 |   0.05856 |
-#> |.....................|    0.7881 |    0.7318 |     1.539 |    0.9751 |
-#> |.....................|    0.6978 |     1.983 |...........|...........|
-#> |    F| Forward Diff. |    -3.987 |     1.119 |   -0.1055 |  -0.04878 |
-#> |.....................|    0.3644 |    0.5797 |  -0.03160 |     1.359 |
-#> |.....................|   -0.4809 |   0.09403 |   -0.4184 |     1.337 |
-#> |.....................|   -0.2770 |    -1.489 |...........|...........|
-#> |   58|     479.58366 |     1.004 |    -1.201 |   -0.9263 |   -0.9359 |
-#> |.....................|    -1.024 |   -0.9915 |   -0.2438 |   -0.8717 |
-#> |.....................|   -0.7986 |    -1.063 |   -0.5667 |   -0.8517 |
-#> |.....................|    -1.066 |   -0.2327 |...........|...........|
-#> |    U|     479.58366 |     91.32 |    -5.401 |   -0.9041 |    -2.198 |
-#> |.....................|    -4.637 |    0.4098 |     1.092 |   0.05855 |
-#> |.....................|    0.7882 |    0.7317 |     1.539 |    0.9749 |
-#> |.....................|    0.6978 |     1.984 |...........|...........|
-#> |    X|     479.58366 |     91.32 |  0.004511 |    0.2882 |    0.1110 |
-#> |.....................|  0.009688 |    0.6010 |     1.092 |   0.05855 |
-#> |.....................|    0.7882 |    0.7317 |     1.539 |    0.9749 |
-#> |.....................|    0.6978 |     1.984 |...........|...........|
-#> |    F| Forward Diff. |     3.434 |     1.122 |  -0.01954 |  -0.06326 |
-#> |.....................|    0.3597 |    0.5645 |  -0.03484 |     1.404 |
-#> |.....................|   -0.4782 |    0.1697 |  -0.05991 |     1.573 |
-#> |.....................|    0.2504 |    -1.489 |...........|...........|
-#> |   59|     479.57994 |     1.003 |    -1.202 |   -0.9262 |   -0.9358 |
-#> |.....................|    -1.025 |   -0.9918 |   -0.2433 |   -0.8720 |
-#> |.....................|   -0.7984 |    -1.063 |   -0.5664 |   -0.8520 |
-#> |.....................|    -1.066 |   -0.2319 |...........|...........|
-#> |    U|     479.57994 |     91.26 |    -5.402 |   -0.9041 |    -2.198 |
-#> |.....................|    -4.637 |    0.4096 |     1.092 |   0.05854 |
-#> |.....................|    0.7884 |    0.7316 |     1.539 |    0.9746 |
-#> |.....................|    0.6977 |     1.985 |...........|...........|
-#> |    X|     479.57994 |     91.26 |  0.004508 |    0.2882 |    0.1110 |
-#> |.....................|  0.009686 |    0.6010 |     1.092 |   0.05854 |
-#> |.....................|    0.7884 |    0.7316 |     1.539 |    0.9746 |
-#> |.....................|    0.6977 |     1.985 |...........|...........|
-#> |    F| Forward Diff. |    -2.328 |     1.117 |  -0.07952 |  -0.05137 |
-#> |.....................|    0.3636 |    0.5738 |   0.02815 |     1.418 |
-#> |.....................|   -0.4669 |    0.1345 |    0.7258 |     2.078 |
-#> |.....................|    0.2949 |    -1.476 |...........|...........|
-#> |   60|     479.57683 |     1.004 |    -1.202 |   -0.9262 |   -0.9358 |
-#> |.....................|    -1.025 |   -0.9921 |   -0.2431 |   -0.8724 |
-#> |.....................|   -0.7982 |    -1.064 |   -0.5667 |   -0.8526 |
-#> |.....................|    -1.066 |   -0.2311 |...........|...........|
-#> |    U|     479.57683 |     91.32 |    -5.402 |   -0.9041 |    -2.198 |
-#> |.....................|    -4.637 |    0.4095 |     1.092 |   0.05853 |
-#> |.....................|    0.7885 |    0.7315 |     1.539 |    0.9740 |
-#> |.....................|    0.6976 |     1.986 |...........|...........|
-#> |    X|     479.57683 |     91.32 |  0.004505 |    0.2882 |    0.1110 |
-#> |.....................|  0.009684 |    0.6010 |     1.092 |   0.05853 |
-#> |.....................|    0.7885 |    0.7315 |     1.539 |    0.9740 |
-#> |.....................|    0.6976 |     1.986 |...........|...........|
-#> |    F| Forward Diff. |     3.369 |     1.121 |  -0.01236 |  -0.06033 |
-#> |.....................|    0.3618 |    0.5608 | -0.009614 |     1.424 |
-#> |.....................|   -0.4677 |    0.1416 |    0.6194 |     1.932 |
-#> |.....................|    0.2634 |    -1.483 |...........|...........|
-#> |   61|     479.57433 |     1.003 |    -1.203 |   -0.9262 |   -0.9358 |
-#> |.....................|    -1.025 |   -0.9924 |   -0.2429 |   -0.8728 |
-#> |.....................|   -0.7980 |    -1.064 |   -0.5671 |   -0.8530 |
-#> |.....................|    -1.066 |   -0.2304 |...........|...........|
-#> |    U|     479.57433 |     91.25 |    -5.403 |   -0.9041 |    -2.198 |
-#> |.....................|    -4.637 |    0.4094 |     1.092 |   0.05852 |
-#> |.....................|    0.7886 |    0.7315 |     1.539 |    0.9736 |
-#> |.....................|    0.6975 |     1.987 |...........|...........|
-#> |    X|     479.57433 |     91.25 |  0.004503 |    0.2882 |    0.1110 |
-#> |.....................|  0.009683 |    0.6009 |     1.092 |   0.05852 |
-#> |.....................|    0.7886 |    0.7315 |     1.539 |    0.9736 |
-#> |.....................|    0.6975 |     1.987 |...........|...........|
-#> |    F| Forward Diff. |    -3.507 |     1.111 |  -0.09183 |  -0.05192 |
-#> |.....................|    0.3614 |    0.5665 |  -0.03887 |     1.349 |
-#> |.....................|   -0.4753 |   0.07826 |    0.5528 |     1.905 |
-#> |.....................|    0.2844 |    -1.468 |...........|...........|
-#> |   62|     479.57116 |     1.003 |    -1.204 |   -0.9262 |   -0.9357 |
-#> |.....................|    -1.025 |   -0.9927 |   -0.2425 |   -0.8732 |
-#> |.....................|   -0.7978 |    -1.064 |   -0.5674 |   -0.8534 |
-#> |.....................|    -1.066 |   -0.2297 |...........|...........|
-#> |    U|     479.57116 |     91.32 |    -5.404 |   -0.9040 |    -2.198 |
-#> |.....................|    -4.638 |    0.4092 |     1.092 |   0.05851 |
-#> |.....................|    0.7888 |    0.7315 |     1.538 |    0.9732 |
-#> |.....................|    0.6973 |     1.988 |...........|...........|
-#> |    X|     479.57116 |     91.32 |  0.004500 |    0.2882 |    0.1110 |
-#> |.....................|  0.009681 |    0.6009 |     1.092 |   0.05851 |
-#> |.....................|    0.7888 |    0.7315 |     1.538 |    0.9732 |
-#> |.....................|    0.6973 |     1.988 |...........|...........|
-#> |    F| Forward Diff. |     2.953 |     1.117 |  -0.01332 |  -0.05913 |
-#> |.....................|    0.3618 |    0.5550 |  -0.01942 |     1.377 |
-#> |.....................|   -0.4588 |    0.1396 |    0.5378 |     1.901 |
-#> |.....................|    0.2564 |    -1.475 |...........|...........|
-#> |   63|     479.56857 |     1.003 |    -1.204 |   -0.9261 |   -0.9357 |
-#> |.....................|    -1.025 |   -0.9930 |   -0.2422 |   -0.8735 |
-#> |.....................|   -0.7976 |    -1.064 |   -0.5677 |   -0.8539 |
-#> |.....................|    -1.066 |   -0.2289 |...........|...........|
-#> |    U|     479.56857 |     91.25 |    -5.404 |   -0.9040 |    -2.198 |
-#> |.....................|    -4.638 |    0.4091 |     1.092 |   0.05850 |
-#> |.....................|    0.7889 |    0.7314 |     1.538 |    0.9728 |
-#> |.....................|    0.6972 |     1.989 |...........|...........|
-#> |    X|     479.56857 |     91.25 |  0.004497 |    0.2882 |    0.1110 |
-#> |.....................|  0.009679 |    0.6009 |     1.092 |   0.05850 |
-#> |.....................|    0.7889 |    0.7314 |     1.538 |    0.9728 |
-#> |.....................|    0.6972 |     1.989 |...........|...........|
-#> |    F| Forward Diff. |    -3.279 |     1.109 |  -0.08378 |  -0.05051 |
-#> |.....................|    0.3625 |    0.5609 |  -0.06234 |     1.320 |
-#> |.....................|   -0.5093 |   0.06989 |    -1.266 |     1.852 |
-#> |.....................|    0.2753 |    -1.463 |...........|...........|
-#> |   64|     479.56430 |     1.003 |    -1.205 |   -0.9261 |   -0.9357 |
-#> |.....................|    -1.026 |   -0.9933 |   -0.2419 |   -0.8738 |
-#> |.....................|   -0.7974 |    -1.064 |   -0.5672 |   -0.8543 |
-#> |.....................|    -1.067 |   -0.2281 |...........|...........|
-#> |    U|      479.5643 |     91.31 |    -5.405 |   -0.9040 |    -2.198 |
-#> |.....................|    -4.638 |    0.4090 |     1.093 |   0.05849 |
-#> |.....................|    0.7891 |    0.7314 |     1.538 |    0.9724 |
-#> |.....................|    0.6971 |     1.990 |...........|...........|
-#> |    X|      479.5643 |     91.31 |  0.004495 |    0.2882 |    0.1110 |
-#> |.....................|  0.009677 |    0.6008 |     1.093 |   0.05849 |
-#> |.....................|    0.7891 |    0.7314 |     1.538 |    0.9724 |
-#> |.....................|    0.6971 |     1.990 |...........|...........|
-#> |    F| Forward Diff. |     2.181 |     1.113 |  -0.01711 |  -0.05862 |
-#> |.....................|    0.3610 |    0.5490 |  -0.06295 |     1.399 |
-#> |.....................|   -0.4495 |    0.1474 |    0.6781 |     1.913 |
-#> |.....................|    0.2455 |    -1.468 |...........|...........|
-#> |   65|     479.56239 |     1.003 |    -1.205 |   -0.9261 |   -0.9356 |
-#> |.....................|    -1.026 |   -0.9935 |   -0.2417 |   -0.8744 |
-#> |.....................|   -0.7972 |    -1.064 |   -0.5674 |   -0.8549 |
-#> |.....................|    -1.067 |   -0.2275 |...........|...........|
-#> |    U|     479.56239 |     91.24 |    -5.405 |   -0.9040 |    -2.198 |
-#> |.....................|    -4.638 |    0.4089 |     1.093 |   0.05847 |
-#> |.....................|    0.7892 |    0.7313 |     1.538 |    0.9718 |
-#> |.....................|    0.6970 |     1.990 |...........|...........|
-#> |    X|     479.56239 |     91.24 |  0.004493 |    0.2882 |    0.1110 |
-#> |.....................|  0.009675 |    0.6008 |     1.093 |   0.05847 |
-#> |.....................|    0.7892 |    0.7313 |     1.538 |    0.9718 |
-#> |.....................|    0.6970 |     1.990 |...........|...........|
-#> |    F| Forward Diff. |    -4.516 |     1.106 |  -0.09308 |  -0.04714 |
-#> |.....................|    0.3636 |    0.5580 |  -0.04406 |     1.488 |
-#> |.....................|   -0.4662 |   0.05187 |    0.6104 |     1.787 |
-#> |.....................|    0.2769 |    -1.453 |...........|...........|
-#> |   66|     479.55877 |     1.003 |    -1.206 |   -0.9261 |   -0.9356 |
-#> |.....................|    -1.026 |   -0.9938 |   -0.2414 |   -0.8747 |
-#> |.....................|   -0.7970 |    -1.064 |   -0.5678 |   -0.8553 |
-#> |.....................|    -1.067 |   -0.2268 |...........|...........|
-#> |    U|     479.55877 |     91.31 |    -5.406 |   -0.9039 |    -2.198 |
-#> |.....................|    -4.638 |    0.4087 |     1.093 |   0.05846 |
-#> |.....................|    0.7894 |    0.7313 |     1.538 |    0.9714 |
-#> |.....................|    0.6969 |     1.991 |...........|...........|
-#> |    X|     479.55877 |     91.31 |  0.004490 |    0.2882 |    0.1110 |
-#> |.....................|  0.009674 |    0.6008 |     1.093 |   0.05846 |
-#> |.....................|    0.7894 |    0.7313 |     1.538 |    0.9714 |
-#> |.....................|    0.6969 |     1.991 |...........|...........|
-#> |    F| Forward Diff. |     2.254 |     1.111 |  -0.01255 |  -0.05783 |
-#> |.....................|    0.3613 |    0.5437 |  -0.01079 |     1.366 |
-#> |.....................|   -0.4954 |    0.1048 |    0.5565 |     1.745 |
-#> |.....................|    0.2417 |    -1.458 |...........|...........|
-#> |   67|     479.55696 |     1.003 |    -1.206 |   -0.9261 |   -0.9356 |
-#> |.....................|    -1.026 |   -0.9940 |   -0.2413 |   -0.8753 |
-#> |.....................|   -0.7968 |    -1.064 |   -0.5681 |   -0.8559 |
-#> |.....................|    -1.067 |   -0.2262 |...........|...........|
-#> |    U|     479.55696 |     91.24 |    -5.406 |   -0.9039 |    -2.198 |
-#> |.....................|    -4.639 |    0.4086 |     1.093 |   0.05845 |
-#> |.....................|    0.7895 |    0.7312 |     1.537 |    0.9708 |
-#> |.....................|    0.6968 |     1.992 |...........|...........|
-#> |    X|     479.55696 |     91.24 |  0.004488 |    0.2882 |    0.1110 |
-#> |.....................|  0.009672 |    0.6008 |     1.093 |   0.05845 |
-#> |.....................|    0.7895 |    0.7312 |     1.537 |    0.9708 |
-#> |.....................|    0.6968 |     1.992 |...........|...........|
-#> |    F| Forward Diff. |    -4.420 |     1.104 |  -0.08938 |  -0.04652 |
-#> |.....................|    0.3638 |    0.5524 |  -0.03600 |     1.474 |
-#> |.....................|   -0.4537 |   0.08714 |    0.5943 |     1.686 |
-#> |.....................|    0.2777 |    -1.443 |...........|...........|
-#> |   68|     479.55331 |     1.003 |    -1.207 |   -0.9260 |   -0.9356 |
-#> |.....................|    -1.026 |   -0.9943 |   -0.2409 |   -0.8756 |
-#> |.....................|   -0.7966 |    -1.064 |   -0.5684 |   -0.8562 |
-#> |.....................|    -1.067 |   -0.2254 |...........|...........|
-#> |    U|     479.55331 |     91.31 |    -5.407 |   -0.9039 |    -2.198 |
-#> |.....................|    -4.639 |    0.4085 |     1.093 |   0.05844 |
-#> |.....................|    0.7897 |    0.7312 |     1.537 |    0.9706 |
-#> |.....................|    0.6966 |     1.993 |...........|...........|
-#> |    X|     479.55331 |     91.31 |  0.004485 |    0.2882 |    0.1110 |
-#> |.....................|  0.009670 |    0.6007 |     1.093 |   0.05844 |
-#> |.....................|    0.7897 |    0.7312 |     1.537 |    0.9706 |
-#> |.....................|    0.6966 |     1.993 |...........|...........|
-#> |    F| Forward Diff. |     1.940 |     1.107 |  -0.01326 |  -0.05734 |
-#> |.....................|    0.3610 |    0.5380 |  -0.03050 |     1.334 |
-#> |.....................|   -0.4419 |   0.09953 |    0.4758 |     1.660 |
-#> |.....................|    0.2363 |    -1.448 |...........|...........|
-#> |   69|     479.55178 |     1.003 |    -1.208 |   -0.9260 |   -0.9355 |
-#> |.....................|    -1.026 |   -0.9945 |   -0.2409 |   -0.8762 |
-#> |.....................|   -0.7964 |    -1.064 |   -0.5686 |   -0.8569 |
-#> |.....................|    -1.067 |   -0.2248 |...........|...........|
-#> |    U|     479.55178 |     91.23 |    -5.408 |   -0.9039 |    -2.198 |
-#> |.....................|    -4.639 |    0.4084 |     1.093 |   0.05842 |
-#> |.....................|    0.7898 |    0.7311 |     1.537 |    0.9699 |
-#> |.....................|    0.6965 |     1.994 |...........|...........|
-#> |    X|     479.55178 |     91.23 |  0.004483 |    0.2882 |    0.1110 |
-#> |.....................|  0.009668 |    0.6007 |     1.093 |   0.05842 |
-#> |.....................|    0.7898 |    0.7311 |     1.537 |    0.9699 |
-#> |.....................|    0.6965 |     1.994 |...........|...........|
-#> |    F| Forward Diff. |    -4.846 |     1.100 |  -0.09130 |  -0.04553 |
-#> |.....................|    0.3638 |    0.5474 |  -0.02936 |     1.430 |
-#> |.....................|   -0.4494 |   0.05105 |    0.6245 |     1.611 |
-#> |.....................|    0.2724 |    -1.435 |...........|...........|
-#> |   70|     479.54790 |     1.003 |    -1.208 |   -0.9260 |   -0.9355 |
-#> |.....................|    -1.027 |   -0.9948 |   -0.2405 |   -0.8765 |
-#> |.....................|   -0.7962 |    -1.064 |   -0.5690 |   -0.8571 |
-#> |.....................|    -1.067 |   -0.2240 |...........|...........|
-#> |    U|      479.5479 |     91.30 |    -5.408 |   -0.9039 |    -2.198 |
-#> |.....................|    -4.639 |    0.4083 |     1.093 |   0.05841 |
-#> |.....................|    0.7899 |    0.7311 |     1.536 |    0.9697 |
-#> |.....................|    0.6964 |     1.995 |...........|...........|
-#> |    X|      479.5479 |     91.30 |  0.004480 |    0.2883 |    0.1110 |
-#> |.....................|  0.009667 |    0.6007 |     1.093 |   0.05841 |
-#> |.....................|    0.7899 |    0.7311 |     1.536 |    0.9697 |
-#> |.....................|    0.6964 |     1.995 |...........|...........|
-#> |    F| Forward Diff. |     1.570 |     1.104 |  -0.01594 |  -0.05674 |
-#> |.....................|    0.3607 |    0.5327 |  -0.02577 |     1.253 |
-#> |.....................|   -0.4401 |   0.07544 |   -0.5163 |    0.8741 |
-#> |.....................|   -0.3456 |    -1.445 |...........|...........|
-#> |   71|     479.54587 |     1.003 |    -1.209 |   -0.9260 |   -0.9355 |
-#> |.....................|    -1.027 |   -0.9951 |   -0.2405 |   -0.8771 |
-#> |.....................|   -0.7960 |    -1.064 |   -0.5687 |   -0.8576 |
-#> |.....................|    -1.067 |   -0.2233 |...........|...........|
-#> |    U|     479.54587 |     91.23 |    -5.409 |   -0.9039 |    -2.198 |
-#> |.....................|    -4.639 |    0.4081 |     1.093 |   0.05839 |
-#> |.....................|    0.7901 |    0.7310 |     1.537 |    0.9693 |
-#> |.....................|    0.6965 |     1.995 |...........|...........|
-#> |    X|     479.54587 |     91.23 |  0.004478 |    0.2883 |    0.1110 |
-#> |.....................|  0.009665 |    0.6006 |     1.093 |   0.05839 |
-#> |.....................|    0.7901 |    0.7310 |     1.537 |    0.9693 |
-#> |.....................|    0.6965 |     1.995 |...........|...........|
-#> |    F| Forward Diff. |    -4.902 |     1.097 |  -0.08880 |  -0.04568 |
-#> |.....................|    0.3633 |    0.5436 |  -0.03820 |     1.421 |
-#> |.....................|   -0.4438 |   0.04451 |    0.5507 |     1.558 |
-#> |.....................|    0.2862 |    -1.423 |...........|...........|
-#> |   72|     479.54157 |     1.003 |    -1.209 |   -0.9260 |   -0.9354 |
-#> |.....................|    -1.027 |   -0.9954 |   -0.2399 |   -0.8773 |
-#> |.....................|   -0.7958 |    -1.064 |   -0.5687 |   -0.8577 |
-#> |.....................|    -1.067 |   -0.2225 |...........|...........|
-#> |    U|     479.54157 |     91.30 |    -5.409 |   -0.9038 |    -2.198 |
-#> |.....................|    -4.639 |    0.4080 |     1.093 |   0.05839 |
-#> |.....................|    0.7902 |    0.7309 |     1.537 |    0.9691 |
-#> |.....................|    0.6965 |     1.996 |...........|...........|
-#> |    X|     479.54157 |     91.30 |  0.004475 |    0.2883 |    0.1110 |
-#> |.....................|  0.009663 |    0.6006 |     1.093 |   0.05839 |
-#> |.....................|    0.7902 |    0.7309 |     1.537 |    0.9691 |
-#> |.....................|    0.6965 |     1.996 |...........|...........|
-#> |    F| Forward Diff. |     1.063 |     1.100 |  -0.01768 |  -0.05631 |
-#> |.....................|    0.3603 |    0.5311 |  -0.05904 |     1.468 |
-#> |.....................|   -0.4400 |   0.06384 |    0.5216 |     1.564 |
-#> |.....................|    0.2548 |    -1.433 |...........|...........|
-#> |   73|     479.53906 |     1.003 |    -1.210 |   -0.9259 |   -0.9354 |
-#> |.....................|    -1.027 |   -0.9956 |   -0.2399 |   -0.8780 |
-#> |.....................|   -0.7956 |    -1.064 |   -0.5689 |   -0.8584 |
-#> |.....................|    -1.067 |   -0.2218 |...........|...........|
-#> |    U|     479.53906 |     91.25 |    -5.410 |   -0.9038 |    -2.198 |
-#> |.....................|    -4.640 |    0.4079 |     1.093 |   0.05837 |
-#> |.....................|    0.7904 |    0.7309 |     1.536 |    0.9684 |
-#> |.....................|    0.6964 |     1.997 |...........|...........|
-#> |    X|     479.53906 |     91.25 |  0.004472 |    0.2883 |    0.1110 |
-#> |.....................|  0.009661 |    0.6006 |     1.093 |   0.05837 |
-#> |.....................|    0.7904 |    0.7309 |     1.536 |    0.9684 |
-#> |.....................|    0.6964 |     1.997 |...........|...........|
-#> |    F| Forward Diff. |    -3.131 |     1.095 |  -0.06506 |  -0.04908 |
-#> |.....................|    0.3620 |    0.5356 | -0.007514 |     1.441 |
-#> |.....................|   -0.4274 |   0.08578 |   -0.3543 |    0.8441 |
-#> |.....................|   -0.2944 |    -1.418 |...........|...........|
-#> |   74|     479.53616 |     1.004 |    -1.210 |   -0.9259 |   -0.9354 |
-#> |.....................|    -1.027 |   -0.9959 |   -0.2396 |   -0.8785 |
-#> |.....................|   -0.7954 |    -1.064 |   -0.5688 |   -0.8586 |
-#> |.....................|    -1.067 |   -0.2210 |...........|...........|
-#> |    U|     479.53616 |     91.33 |    -5.410 |   -0.9038 |    -2.198 |
-#> |.....................|    -4.640 |    0.4077 |     1.094 |   0.05835 |
-#> |.....................|    0.7905 |    0.7308 |     1.537 |    0.9682 |
-#> |.....................|    0.6965 |     1.998 |...........|...........|
-#> |    X|     479.53616 |     91.33 |  0.004470 |    0.2883 |    0.1111 |
-#> |.....................|  0.009659 |    0.6005 |     1.094 |   0.05835 |
-#> |.....................|    0.7905 |    0.7308 |     1.537 |    0.9682 |
-#> |.....................|    0.6965 |     1.998 |...........|...........|
-#> |    F| Forward Diff. |     3.979 |     1.099 |   0.01619 |  -0.06233 |
-#> |.....................|    0.3580 |    0.5217 |  -0.09749 |     1.245 |
-#> |.....................|   -0.4289 |    0.1115 |   -0.5282 |    0.7580 |
-#> |.....................|   -0.3266 |    -1.417 |...........|...........|
-#> |   75|     479.53242 |     1.003 |    -1.211 |   -0.9259 |   -0.9353 |
-#> |.....................|    -1.028 |   -0.9962 |   -0.2391 |   -0.8787 |
-#> |.....................|   -0.7953 |    -1.065 |   -0.5685 |   -0.8588 |
-#> |.....................|    -1.067 |   -0.2202 |...........|...........|
-#> |    U|     479.53242 |     91.27 |    -5.411 |   -0.9038 |    -2.198 |
-#> |.....................|    -4.640 |    0.4076 |     1.094 |   0.05835 |
-#> |.....................|    0.7906 |    0.7307 |     1.537 |    0.9681 |
-#> |.....................|    0.6966 |     1.999 |...........|...........|
-#> |    X|     479.53242 |     91.27 |  0.004467 |    0.2883 |    0.1111 |
-#> |.....................|  0.009657 |    0.6005 |     1.094 |   0.05835 |
-#> |.....................|    0.7906 |    0.7307 |     1.537 |    0.9681 |
-#> |.....................|    0.6966 |     1.999 |...........|...........|
-#> |    F| Forward Diff. |    -1.679 |     1.093 |  -0.04308 |  -0.05224 |
-#> |.....................|    0.3605 |    0.5318 | -0.002555 |     1.446 |
-#> |.....................|   -0.4215 |   0.05786 |    0.6079 |     1.538 |
-#> |.....................|    0.2997 |    -1.401 |...........|...........|
-#> |   76|     479.52958 |     1.004 |    -1.212 |   -0.9259 |   -0.9353 |
-#> |.....................|    -1.028 |   -0.9965 |   -0.2388 |   -0.8793 |
-#> |.....................|   -0.7951 |    -1.065 |   -0.5686 |   -0.8593 |
-#> |.....................|    -1.067 |   -0.2194 |...........|...........|
-#> |    U|     479.52958 |     91.33 |    -5.412 |   -0.9038 |    -2.198 |
-#> |.....................|    -4.640 |    0.4075 |     1.094 |   0.05833 |
-#> |.....................|    0.7908 |    0.7306 |     1.537 |    0.9676 |
-#> |.....................|    0.6965 |     2.000 |...........|...........|
-#> |    X|     479.52958 |     91.33 |  0.004464 |    0.2883 |    0.1111 |
-#> |.....................|  0.009655 |    0.6005 |     1.094 |   0.05833 |
-#> |.....................|    0.7908 |    0.7306 |     1.537 |    0.9676 |
-#> |.....................|    0.6965 |     2.000 |...........|...........|
-#> |    F| Forward Diff. |     3.139 |     1.094 |   0.01046 |  -0.06226 |
-#> |.....................|    0.3570 |    0.5194 |  -0.09592 |     1.421 |
-#> |.....................|   -0.4323 |   0.06052 |   -0.5454 |    0.7071 |
-#> |.....................|   -0.2962 |    -1.410 |...........|...........|
-#> |   77|     479.52646 |     1.003 |    -1.212 |   -0.9259 |   -0.9353 |
-#> |.....................|    -1.028 |   -0.9968 |   -0.2384 |   -0.8797 |
-#> |.....................|   -0.7949 |    -1.065 |   -0.5684 |   -0.8594 |
-#> |.....................|    -1.067 |   -0.2186 |...........|...........|
-#> |    U|     479.52646 |     91.26 |    -5.412 |   -0.9038 |    -2.198 |
-#> |.....................|    -4.640 |    0.4073 |     1.094 |   0.05832 |
-#> |.....................|    0.7909 |    0.7304 |     1.537 |    0.9675 |
-#> |.....................|    0.6966 |     2.001 |...........|...........|
-#> |    X|     479.52646 |     91.26 |  0.004461 |    0.2883 |    0.1111 |
-#> |.....................|  0.009653 |    0.6005 |     1.094 |   0.05832 |
-#> |.....................|    0.7909 |    0.7304 |     1.537 |    0.9675 |
-#> |.....................|    0.6966 |     2.001 |...........|...........|
-#> |    F| Forward Diff. |    -2.758 |     1.088 |  -0.05217 |  -0.05158 |
-#> |.....................|    0.3593 |    0.5291 |  -0.05980 |     1.185 |
-#> |.....................|   -0.4227 |    -2.218 |   -0.3659 |    0.8223 |
-#> |.....................|   -0.2423 |    -1.392 |...........|...........|
-#> |   78|     479.52294 |     1.003 |    -1.213 |   -0.9258 |   -0.9352 |
-#> |.....................|    -1.028 |   -0.9971 |   -0.2379 |   -0.8800 |
-#> |.....................|   -0.7947 |    -1.064 |   -0.5681 |   -0.8596 |
-#> |.....................|    -1.067 |   -0.2178 |...........|...........|
-#> |    U|     479.52294 |     91.30 |    -5.413 |   -0.9037 |    -2.198 |
-#> |.....................|    -4.641 |    0.4072 |     1.094 |   0.05831 |
-#> |.....................|    0.7910 |    0.7311 |     1.537 |    0.9673 |
-#> |.....................|    0.6967 |     2.002 |...........|...........|
-#> |    X|     479.52294 |     91.30 |  0.004458 |    0.2883 |    0.1111 |
-#> |.....................|  0.009652 |    0.6004 |     1.094 |   0.05831 |
-#> |.....................|    0.7910 |    0.7311 |     1.537 |    0.9673 |
-#> |.....................|    0.6967 |     2.002 |...........|...........|
-#> |    F| Forward Diff. |    0.7571 |     1.091 |  -0.01328 |  -0.05733 |
-#> |.....................|    0.3573 |    0.5211 |  0.006105 |     1.423 |
-#> |.....................|   -0.4119 |    0.1268 |    0.6771 |     1.465 |
-#> |.....................|    0.3146 |    -1.386 |...........|...........|
-#> |   79|     479.52041 |     1.003 |    -1.213 |   -0.9258 |   -0.9352 |
-#> |.....................|    -1.028 |   -0.9973 |   -0.2380 |   -0.8807 |
-#> |.....................|   -0.7945 |    -1.064 |   -0.5684 |   -0.8604 |
-#> |.....................|    -1.067 |   -0.2172 |...........|...........|
-#> |    U|     479.52041 |     91.27 |    -5.413 |   -0.9037 |    -2.198 |
-#> |.....................|    -4.641 |    0.4071 |     1.094 |   0.05829 |
-#> |.....................|    0.7912 |    0.7311 |     1.537 |    0.9666 |
-#> |.....................|    0.6965 |     2.003 |...........|...........|
-#> |    X|     479.52041 |     91.27 |  0.004456 |    0.2883 |    0.1111 |
-#> |.....................|  0.009650 |    0.6004 |     1.094 |   0.05829 |
-#> |.....................|    0.7912 |    0.7311 |     1.537 |    0.9666 |
-#> |.....................|    0.6965 |     2.003 |...........|...........|
-#> |    F| Forward Diff. |    -2.400 |     1.087 |  -0.04852 |  -0.05189 |
-#> |.....................|    0.3585 |    0.5236 |  -0.05100 |     1.183 |
-#> |.....................|   -0.4319 |   0.01564 |    0.3566 |     1.324 |
-#> |.....................|    0.3221 |    -1.379 |...........|...........|
-#> |   80|     479.51911 |     1.004 |    -1.214 |   -0.9258 |   -0.9352 |
-#> |.....................|    -1.029 |   -0.9976 |   -0.2379 |   -0.8812 |
-#> |.....................|   -0.7944 |    -1.064 |   -0.5686 |   -0.8609 |
-#> |.....................|    -1.067 |   -0.2166 |...........|...........|
-#> |    U|     479.51911 |     91.35 |    -5.414 |   -0.9037 |    -2.198 |
-#> |.....................|    -4.641 |    0.4070 |     1.094 |   0.05828 |
-#> |.....................|    0.7913 |    0.7310 |     1.537 |    0.9661 |
-#> |.....................|    0.6964 |     2.004 |...........|...........|
-#> |    X|     479.51911 |     91.35 |  0.004454 |    0.2883 |    0.1111 |
-#> |.....................|  0.009648 |    0.6004 |     1.094 |   0.05828 |
-#> |.....................|    0.7913 |    0.7310 |     1.537 |    0.9661 |
-#> |.....................|    0.6964 |     2.004 |...........|...........|
-#> |    F| Forward Diff. |     5.458 |     1.092 |   0.04306 |  -0.06507 |
-#> |.....................|    0.3552 |    0.5068 |  -0.06807 |     1.418 |
-#> |.....................|   -0.4090 |    0.1358 |   -0.5109 |    0.5676 |
-#> |.....................|   -0.2804 |    -1.390 |...........|...........|
-#> |   81|     479.51487 |     1.003 |    -1.215 |   -0.9258 |   -0.9352 |
-#> |.....................|    -1.029 |   -0.9978 |   -0.2377 |   -0.8817 |
-#> |.....................|   -0.7942 |    -1.064 |   -0.5685 |   -0.8612 |
-#> |.....................|    -1.067 |   -0.2158 |...........|...........|
-#> |    U|     479.51487 |     91.27 |    -5.415 |   -0.9037 |    -2.198 |
-#> |.....................|    -4.641 |    0.4069 |     1.094 |   0.05826 |
-#> |.....................|    0.7914 |    0.7307 |     1.537 |    0.9658 |
-#> |.....................|    0.6963 |     2.005 |...........|...........|
-#> |    X|     479.51487 |     91.27 |  0.004451 |    0.2883 |    0.1111 |
-#> |.....................|  0.009647 |    0.6003 |     1.094 |   0.05826 |
-#> |.....................|    0.7914 |    0.7307 |     1.537 |    0.9658 |
-#> |.....................|    0.6963 |     2.005 |...........|...........|
-#> |    F| Forward Diff. |    -1.582 |     1.084 |  -0.03533 |  -0.05340 |
-#> |.....................|    0.3581 |    0.5175 |  -0.06480 |     1.157 |
-#> |.....................|   -0.4224 |   0.03489 |   -0.5536 |    0.6041 |
-#> |.....................|   -0.2386 |    -1.371 |...........|...........|
-#> |   82|     479.51208 |     1.004 |    -1.215 |   -0.9258 |   -0.9351 |
-#> |.....................|    -1.029 |   -0.9981 |   -0.2375 |   -0.8823 |
-#> |.....................|   -0.7939 |    -1.065 |   -0.5682 |   -0.8615 |
-#> |.....................|    -1.067 |   -0.2150 |...........|...........|
-#> |    U|     479.51208 |     91.34 |    -5.415 |   -0.9037 |    -2.197 |
-#> |.....................|    -4.641 |    0.4067 |     1.094 |   0.05824 |
-#> |.....................|    0.7916 |    0.7306 |     1.537 |    0.9655 |
-#> |.....................|    0.6964 |     2.006 |...........|...........|
-#> |    X|     479.51208 |     91.34 |  0.004449 |    0.2883 |    0.1111 |
-#> |.....................|  0.009645 |    0.6003 |     1.094 |   0.05824 |
-#> |.....................|    0.7916 |    0.7306 |     1.537 |    0.9655 |
-#> |.....................|    0.6964 |     2.006 |...........|...........|
-#> |    F| Forward Diff. |     3.943 |     1.087 |   0.02817 |  -0.06279 |
-#> |.....................|    0.3555 |    0.5065 |  -0.06060 |     1.305 |
-#> |.....................|   -0.4115 |   0.06912 |    0.4865 |     1.240 |
-#> |.....................|    0.2990 |    -1.371 |...........|...........|
-#> |   83|     479.50842 |     1.003 |    -1.216 |   -0.9258 |   -0.9351 |
-#> |.....................|    -1.029 |   -0.9984 |   -0.2372 |   -0.8827 |
-#> |.....................|   -0.7937 |    -1.065 |   -0.5683 |   -0.8618 |
-#> |.....................|    -1.067 |   -0.2141 |...........|...........|
-#> |    U|     479.50842 |     91.29 |    -5.416 |   -0.9037 |    -2.197 |
-#> |.....................|    -4.642 |    0.4066 |     1.095 |   0.05823 |
-#> |.....................|    0.7918 |    0.7302 |     1.537 |    0.9652 |
-#> |.....................|    0.6962 |     2.007 |...........|...........|
-#> |    X|     479.50842 |     91.29 |  0.004446 |    0.2883 |    0.1111 |
-#> |.....................|  0.009643 |    0.6003 |     1.095 |   0.05823 |
-#> |.....................|    0.7918 |    0.7302 |     1.537 |    0.9652 |
-#> |.....................|    0.6962 |     2.007 |...........|...........|
-#> |    F| Forward Diff. |   -0.7463 |     1.081 |  -0.02105 |  -0.05532 |
-#> |.....................|    0.3572 |    0.5118 |  -0.07839 |     1.134 |
-#> |.....................|   -0.4206 |   0.01709 |   -0.5616 |    0.5218 |
-#> |.....................|   -0.2429 |    -1.361 |...........|...........|
-#> |   84|     479.50515 |     1.004 |    -1.216 |   -0.9258 |   -0.9351 |
-#> |.....................|    -1.029 |   -0.9987 |   -0.2372 |   -0.8834 |
-#> |.....................|   -0.7935 |    -1.065 |   -0.5680 |   -0.8621 |
-#> |.....................|    -1.067 |   -0.2133 |...........|...........|
-#> |    U|     479.50515 |     91.33 |    -5.416 |   -0.9037 |    -2.197 |
-#> |.....................|    -4.642 |    0.4065 |     1.095 |   0.05821 |
-#> |.....................|    0.7919 |    0.7302 |     1.537 |    0.9649 |
-#> |.....................|    0.6964 |     2.008 |...........|...........|
-#> |    X|     479.50515 |     91.33 |  0.004443 |    0.2883 |    0.1111 |
-#> |.....................|  0.009641 |    0.6002 |     1.095 |   0.05821 |
-#> |.....................|    0.7919 |    0.7302 |     1.537 |    0.9649 |
-#> |.....................|    0.6964 |     2.008 |...........|...........|
-#> |   85|     479.49887 |     1.004 |    -1.219 |   -0.9257 |   -0.9350 |
-#> |.....................|    -1.030 |   -0.9997 |   -0.2363 |   -0.8851 |
-#> |.....................|   -0.7928 |    -1.066 |   -0.5675 |   -0.8630 |
-#> |.....................|    -1.067 |   -0.2104 |...........|...........|
-#> |    U|     479.49887 |     91.39 |    -5.419 |   -0.9037 |    -2.197 |
-#> |.....................|    -4.642 |    0.4060 |     1.095 |   0.05816 |
-#> |.....................|    0.7925 |    0.7293 |     1.538 |    0.9641 |
-#> |.....................|    0.6963 |     2.011 |...........|...........|
-#> |    X|     479.49887 |     91.39 |  0.004434 |    0.2883 |    0.1111 |
-#> |.....................|  0.009634 |    0.6001 |     1.095 |   0.05816 |
-#> |.....................|    0.7925 |    0.7293 |     1.538 |    0.9641 |
-#> |.....................|    0.6963 |     2.011 |...........|...........|
-#> |    F| Forward Diff. |     8.922 |     1.081 |    0.1004 |  -0.07252 |
-#> |.....................|    0.3520 |    0.4871 |    0.2543 |     1.578 |
-#> |.....................|   -0.3854 |   0.03465 |   -0.5794 |    0.4083 |
-#> |.....................|   -0.2550 |    -1.344 |...........|...........|
-#> |   86|     479.48147 |     1.003 |    -1.221 |   -0.9257 |   -0.9348 |
-#> |.....................|    -1.031 |    -1.001 |   -0.2344 |   -0.8861 |
-#> |.....................|   -0.7921 |    -1.067 |   -0.5658 |   -0.8636 |
-#> |.....................|    -1.067 |   -0.2068 |...........|...........|
-#> |    U|     479.48147 |     91.29 |    -5.421 |   -0.9036 |    -2.197 |
-#> |.....................|    -4.643 |    0.4054 |     1.096 |   0.05813 |
-#> |.....................|    0.7930 |    0.7283 |     1.540 |    0.9635 |
-#> |.....................|    0.6963 |     2.016 |...........|...........|
-#> |    X|     479.48147 |     91.29 |  0.004421 |    0.2883 |    0.1111 |
-#> |.....................|  0.009626 |    0.6000 |     1.096 |   0.05813 |
-#> |.....................|    0.7930 |    0.7283 |     1.540 |    0.9635 |
-#> |.....................|    0.6963 |     2.016 |...........|...........|
-#> |   87|     479.46291 |     1.003 |    -1.226 |   -0.9256 |   -0.9345 |
-#> |.....................|    -1.032 |    -1.003 |   -0.2312 |   -0.8874 |
-#> |.....................|   -0.7910 |    -1.069 |   -0.5631 |   -0.8644 |
-#> |.....................|    -1.067 |   -0.2012 |...........|...........|
-#> |    U|     479.46291 |     91.29 |    -5.426 |   -0.9035 |    -2.197 |
-#> |.....................|    -4.645 |    0.4045 |     1.097 |   0.05809 |
-#> |.....................|    0.7937 |    0.7267 |     1.543 |    0.9627 |
-#> |.....................|    0.6964 |     2.022 |...........|...........|
-#> |    X|     479.46291 |     91.29 |  0.004402 |    0.2883 |    0.1111 |
-#> |.....................|  0.009612 |    0.5998 |     1.097 |   0.05809 |
-#> |.....................|    0.7937 |    0.7267 |     1.543 |    0.9627 |
-#> |.....................|    0.6964 |     2.022 |...........|...........|
-#> |   88|     479.38653 |     1.003 |    -1.248 |   -0.9250 |   -0.9332 |
-#> |.....................|    -1.039 |    -1.013 |   -0.2154 |   -0.8940 |
-#> |.....................|   -0.7859 |    -1.078 |   -0.5497 |   -0.8687 |
-#> |.....................|    -1.067 |   -0.1734 |...........|...........|
-#> |    U|     479.38653 |     91.26 |    -5.448 |   -0.9030 |    -2.196 |
-#> |.....................|    -4.652 |    0.4000 |     1.104 |   0.05790 |
-#> |.....................|    0.7975 |    0.7188 |     1.559 |    0.9587 |
-#> |.....................|    0.6966 |     2.056 |...........|...........|
-#> |    X|     479.38653 |     91.26 |  0.004306 |    0.2884 |    0.1113 |
-#> |.....................|  0.009547 |    0.5987 |     1.104 |   0.05790 |
-#> |.....................|    0.7975 |    0.7188 |     1.559 |    0.9587 |
-#> |.....................|    0.6966 |     2.056 |...........|...........|
-#> |   89|     479.33405 |     1.002 |    -1.333 |   -0.9226 |   -0.9281 |
-#> |.....................|    -1.066 |    -1.051 |   -0.1533 |   -0.9198 |
-#> |.....................|   -0.7659 |    -1.112 |   -0.4971 |   -0.8853 |
-#> |.....................|    -1.066 |  -0.06439 |...........|...........|
-#> |    U|     479.33405 |     91.15 |    -5.533 |   -0.9008 |    -2.190 |
-#> |.....................|    -4.678 |    0.3823 |     1.129 |   0.05715 |
-#> |.....................|    0.8121 |    0.6876 |     1.621 |    0.9427 |
-#> |.....................|    0.6975 |     2.188 |...........|...........|
-#> |    X|     479.33405 |     91.15 |  0.003953 |    0.2889 |    0.1119 |
-#> |.....................|  0.009294 |    0.5944 |     1.129 |   0.05715 |
-#> |.....................|    0.8121 |    0.6876 |     1.621 |    0.9427 |
-#> |.....................|    0.6975 |     2.188 |...........|...........|
-#> |    F| Forward Diff. |    -22.35 |    0.8049 |    0.3265 |  -0.06456 |
-#> |.....................|    0.3038 |    0.2091 |     1.763 |     1.473 |
-#> |.....................|   -0.5535 |    -2.463 |     1.244 |   -0.6274 |
-#> |.....................|     1.702 |   -0.2760 |...........|...........|
-#> |   90|     479.70817 |     1.005 |    -1.492 |   -0.9504 |   -0.9122 |
-#> |.....................|    -1.121 |    -1.106 |   -0.1774 |   -0.9510 |
-#> |.....................|   -0.7305 |    -1.145 |   -0.4385 |   -0.8800 |
-#> |.....................|    -1.177 |  -0.01012 |...........|...........|
-#> |    U|     479.70817 |     91.47 |    -5.692 |   -0.9256 |    -2.175 |
-#> |.....................|    -4.734 |    0.3572 |     1.119 |   0.05625 |
-#> |.....................|    0.8380 |    0.6579 |     1.691 |    0.9478 |
-#> |.....................|    0.6020 |     2.254 |...........|...........|
-#> |    X|     479.70817 |     91.47 |  0.003371 |    0.2838 |    0.1137 |
-#> |.....................|  0.008794 |    0.5884 |     1.119 |   0.05625 |
-#> |.....................|    0.8380 |    0.6579 |     1.691 |    0.9478 |
-#> |.....................|    0.6020 |     2.254 |...........|...........|
-#> |   91|     479.27063 |     1.005 |    -1.375 |   -0.9298 |   -0.9240 |
-#> |.....................|    -1.080 |    -1.065 |   -0.1597 |   -0.9281 |
-#> |.....................|   -0.7567 |    -1.120 |   -0.4820 |   -0.8839 |
-#> |.....................|    -1.095 |  -0.05030 |...........|...........|
-#> |    U|     479.27063 |     91.42 |    -5.575 |   -0.9073 |    -2.186 |
-#> |.....................|    -4.693 |    0.3758 |     1.127 |   0.05692 |
-#> |.....................|    0.8189 |    0.6801 |     1.639 |    0.9441 |
-#> |.....................|    0.6726 |     2.206 |...........|...........|
-#> |    X|     479.27063 |     91.42 |  0.003793 |    0.2876 |    0.1123 |
-#> |.....................|  0.009162 |    0.5929 |     1.127 |   0.05692 |
-#> |.....................|    0.8189 |    0.6801 |     1.639 |    0.9441 |
-#> |.....................|    0.6726 |     2.206 |...........|...........|
-#> |    F| Forward Diff. |     2.862 |    0.7516 |    0.3576 |  -0.07893 |
-#> |.....................|    0.2806 |   -0.4298 |     1.369 |     1.213 |
-#> |.....................|   -0.5227 |    -2.562 |     2.801 |    -1.010 |
-#> |.....................|    -1.234 |   -0.5388 |...........|...........|
-#> |   92|     479.18239 |     1.005 |    -1.423 |   -0.9401 |   -0.9189 |
-#> |.....................|    -1.098 |    -1.064 |   -0.1729 |   -0.9195 |
-#> |.....................|   -0.7414 |    -1.117 |   -0.4967 |   -0.8806 |
-#> |.....................|    -1.083 |  -0.04375 |...........|...........|
-#> |    U|     479.18239 |     91.43 |    -5.623 |   -0.9165 |    -2.181 |
-#> |.....................|    -4.710 |    0.3764 |     1.121 |   0.05716 |
-#> |.....................|    0.8300 |    0.6834 |     1.622 |    0.9472 |
-#> |.....................|    0.6830 |     2.213 |...........|...........|
-#> |    X|     479.18239 |     91.43 |  0.003613 |    0.2857 |    0.1129 |
-#> |.....................|  0.009001 |    0.5930 |     1.121 |   0.05716 |
-#> |.....................|    0.8300 |    0.6834 |     1.622 |    0.9472 |
-#> |.....................|    0.6830 |     2.213 |...........|...........|
-#> |    F| Forward Diff. |     2.797 |    0.6564 |   -0.1913 |  -0.04289 |
-#> |.....................|    0.2359 |   -0.3012 |     1.209 |     1.124 |
-#> |.....................|   -0.4349 |    -2.322 |     2.160 |   -0.7215 |
-#> |.....................|   -0.1578 |   -0.4171 |...........|...........|
-#> |   93|     479.53483 |    0.9938 |    -1.508 |   -0.8927 |   -0.9141 |
-#> |.....................|    -1.127 |    -1.054 |   -0.1802 |   -0.9016 |
-#> |.....................|   -0.7110 |    -1.089 |   -0.5260 |   -0.8567 |
-#> |.....................|    -1.093 |  -0.01567 |...........|...........|
-#> |    U|     479.53483 |     90.44 |    -5.708 |   -0.8742 |    -2.177 |
-#> |.....................|    -4.740 |    0.3812 |     1.118 |   0.05768 |
-#> |.....................|    0.8523 |    0.7081 |     1.587 |    0.9700 |
-#> |.....................|    0.6741 |     2.248 |...........|...........|
-#> |    X|     479.53483 |     90.44 |  0.003320 |    0.2944 |    0.1134 |
-#> |.....................|  0.008741 |    0.5942 |     1.118 |   0.05768 |
-#> |.....................|    0.8523 |    0.7081 |     1.587 |    0.9700 |
-#> |.....................|    0.6741 |     2.248 |...........|...........|
-#> |   94|     479.57437 |    0.9943 |    -1.436 |   -0.9336 |   -0.9181 |
-#> |.....................|    -1.102 |    -1.062 |   -0.1777 |   -0.9209 |
-#> |.....................|   -0.7362 |    -1.106 |   -0.5073 |   -0.8753 |
-#> |.....................|    -1.084 |  -0.03890 |...........|...........|
-#> |    U|     479.57437 |     90.49 |    -5.636 |   -0.9106 |    -2.181 |
-#> |.....................|    -4.715 |    0.3775 |     1.119 |   0.05712 |
-#> |.....................|    0.8338 |    0.6933 |     1.609 |    0.9523 |
-#> |.....................|    0.6824 |     2.219 |...........|...........|
-#> |    X|     479.57437 |     90.49 |  0.003567 |    0.2869 |    0.1130 |
-#> |.....................|  0.008961 |    0.5933 |     1.119 |   0.05712 |
-#> |.....................|    0.8338 |    0.6933 |     1.609 |    0.9523 |
-#> |.....................|    0.6824 |     2.219 |...........|...........|
-#> |   95|     479.18328 |     1.003 |    -1.424 |   -0.9400 |   -0.9189 |
-#> |.....................|    -1.098 |    -1.064 |   -0.1736 |   -0.9201 |
-#> |.....................|   -0.7412 |    -1.115 |   -0.4980 |   -0.8802 |
-#> |.....................|    -1.083 |  -0.04351 |...........|...........|
-#> |    U|     479.18328 |     91.28 |    -5.624 |   -0.9164 |    -2.181 |
-#> |.....................|    -4.711 |    0.3765 |     1.121 |   0.05715 |
-#> |.....................|    0.8302 |    0.6847 |     1.620 |    0.9476 |
-#> |.....................|    0.6831 |     2.214 |...........|...........|
-#> |    X|     479.18328 |     91.28 |  0.003612 |    0.2857 |    0.1129 |
-#> |.....................|  0.009000 |    0.5930 |     1.121 |   0.05715 |
-#> |.....................|    0.8302 |    0.6847 |     1.620 |    0.9476 |
-#> |.....................|    0.6831 |     2.214 |...........|...........|
-#> |   96|     479.17990 |     1.004 |    -1.423 |   -0.9401 |   -0.9189 |
-#> |.....................|    -1.098 |    -1.064 |   -0.1732 |   -0.9198 |
-#> |.....................|   -0.7413 |    -1.116 |   -0.4973 |   -0.8805 |
-#> |.....................|    -1.083 |  -0.04364 |...........|...........|
-#> |    U|      479.1799 |     91.36 |    -5.623 |   -0.9164 |    -2.181 |
-#> |.....................|    -4.710 |    0.3764 |     1.121 |   0.05716 |
-#> |.....................|    0.8301 |    0.6840 |     1.621 |    0.9474 |
-#> |.....................|    0.6831 |     2.214 |...........|...........|
-#> |    X|      479.1799 |     91.36 |  0.003612 |    0.2857 |    0.1129 |
-#> |.....................|  0.009001 |    0.5930 |     1.121 |   0.05716 |
-#> |.....................|    0.8301 |    0.6840 |     1.621 |    0.9474 |
-#> |.....................|    0.6831 |     2.214 |...........|...........|
-#> |    F| Forward Diff. |    -3.933 |    0.6514 |   -0.2757 |  -0.03244 |
-#> |.....................|    0.2382 |   -0.2823 |     1.183 |     1.090 |
-#> |.....................|   -0.4397 |    -2.345 |     2.145 |   -0.7620 |
-#> |.....................|   -0.1240 |   -0.3947 |...........|...........|
-#> |   97|     479.17667 |     1.005 |    -1.424 |   -0.9399 |   -0.9189 |
-#> |.....................|    -1.098 |    -1.064 |   -0.1735 |   -0.9200 |
-#> |.....................|   -0.7411 |    -1.116 |   -0.4978 |   -0.8802 |
-#> |.....................|    -1.083 |  -0.04350 |...........|...........|
-#> |    U|     479.17667 |     91.44 |    -5.624 |   -0.9162 |    -2.181 |
-#> |.....................|    -4.711 |    0.3765 |     1.121 |   0.05715 |
-#> |.....................|    0.8302 |    0.6845 |     1.621 |    0.9476 |
-#> |.....................|    0.6831 |     2.214 |...........|...........|
-#> |    X|     479.17667 |     91.44 |  0.003611 |    0.2857 |    0.1129 |
-#> |.....................|  0.009000 |    0.5930 |     1.121 |   0.05715 |
-#> |.....................|    0.8302 |    0.6845 |     1.621 |    0.9476 |
-#> |.....................|    0.6831 |     2.214 |...........|...........|
-#> |    F| Forward Diff. |     3.521 |    0.6547 |   -0.1751 |  -0.04313 |
-#> |.....................|    0.2353 |   -0.2995 |     1.118 |     1.121 |
-#> |.....................|   -0.4506 |    -2.323 |     2.084 |   -0.7259 |
-#> |.....................|   -0.1653 |   -0.4503 |...........|...........|
-#> |   98|     479.17418 |     1.004 |    -1.424 |   -0.9398 |   -0.9188 |
-#> |.....................|    -1.098 |    -1.064 |   -0.1738 |   -0.9202 |
-#> |.....................|   -0.7410 |    -1.115 |   -0.4983 |   -0.8800 |
-#> |.....................|    -1.083 |  -0.04335 |...........|...........|
-#> |    U|     479.17418 |     91.36 |    -5.624 |   -0.9161 |    -2.181 |
-#> |.....................|    -4.711 |    0.3765 |     1.121 |   0.05714 |
-#> |.....................|    0.8303 |    0.6850 |     1.620 |    0.9478 |
-#> |.....................|    0.6831 |     2.214 |...........|...........|
-#> |    X|     479.17418 |     91.36 |  0.003610 |    0.2857 |    0.1129 |
-#> |.....................|  0.008999 |    0.5930 |     1.121 |   0.05714 |
-#> |.....................|    0.8303 |    0.6850 |     1.620 |    0.9478 |
-#> |.....................|    0.6831 |     2.214 |...........|...........|
-#> |    F| Forward Diff. |    -3.859 |    0.6491 |   -0.2708 |  -0.03145 |
-#> |.....................|    0.2380 |   -0.2786 |     1.113 |     1.074 |
-#> |.....................|   -0.4387 |    -2.285 |     2.045 |   -0.7498 |
-#> |.....................|   -0.1354 |   -0.4011 |...........|...........|
-#> |   99|     479.17107 |     1.005 |    -1.424 |   -0.9396 |   -0.9188 |
-#> |.....................|    -1.098 |    -1.064 |   -0.1740 |   -0.9204 |
-#> |.....................|   -0.7408 |    -1.114 |   -0.4988 |   -0.8798 |
-#> |.....................|    -1.083 |  -0.04320 |...........|...........|
-#> |    U|     479.17107 |     91.44 |    -5.624 |   -0.9160 |    -2.181 |
-#> |.....................|    -4.711 |    0.3766 |     1.121 |   0.05714 |
-#> |.....................|    0.8305 |    0.6855 |     1.619 |    0.9480 |
-#> |.....................|    0.6831 |     2.214 |...........|...........|
-#> |    X|     479.17107 |     91.44 |  0.003609 |    0.2858 |    0.1129 |
-#> |.....................|  0.008997 |    0.5930 |     1.121 |   0.05714 |
-#> |.....................|    0.8305 |    0.6855 |     1.619 |    0.9480 |
-#> |.....................|    0.6831 |     2.214 |...........|...........|
-#> |    F| Forward Diff. |     3.569 |    0.6522 |   -0.1642 |  -0.04243 |
-#> |.....................|    0.2349 |   -0.2958 |     1.101 |     1.106 |
-#> |.....................|   -0.4222 |    -2.201 |     1.058 |   -0.2096 |
-#> |.....................|    0.2358 |   -0.4015 |...........|...........|
-#> |  100|     479.16873 |     1.004 |    -1.425 |   -0.9393 |   -0.9188 |
-#> |.....................|    -1.099 |    -1.064 |   -0.1743 |   -0.9206 |
-#> |.....................|   -0.7406 |    -1.114 |   -0.4991 |   -0.8797 |
-#> |.....................|    -1.083 |  -0.04303 |...........|...........|
-#> |    U|     479.16873 |     91.36 |    -5.625 |   -0.9158 |    -2.181 |
-#> |.....................|    -4.711 |    0.3766 |     1.121 |   0.05713 |
-#> |.....................|    0.8306 |    0.6860 |     1.619 |    0.9481 |
-#> |.....................|    0.6830 |     2.214 |...........|...........|
-#> |    X|     479.16873 |     91.36 |  0.003607 |    0.2858 |    0.1129 |
-#> |.....................|  0.008996 |    0.5931 |     1.121 |   0.05713 |
-#> |.....................|    0.8306 |    0.6860 |     1.619 |    0.9481 |
-#> |.....................|    0.6830 |     2.214 |...........|...........|
-#> |    F| Forward Diff. |    -3.833 |    0.6464 |   -0.2551 |  -0.03020 |
-#> |.....................|    0.2388 |   -0.2745 |     1.092 |     1.036 |
-#> |.....................|   -0.4378 |    -2.238 |     1.100 |   -0.2036 |
-#> |.....................|    0.2823 |   -0.3907 |...........|...........|
-#> |  101|     479.16547 |     1.005 |    -1.426 |   -0.9390 |   -0.9187 |
-#> |.....................|    -1.099 |    -1.063 |   -0.1745 |   -0.9206 |
-#> |.....................|   -0.7403 |    -1.113 |   -0.4993 |   -0.8795 |
-#> |.....................|    -1.083 |  -0.04283 |...........|...........|
-#> |    U|     479.16547 |     91.42 |    -5.626 |   -0.9155 |    -2.181 |
-#> |.....................|    -4.711 |    0.3767 |     1.121 |   0.05713 |
-#> |.....................|    0.8308 |    0.6865 |     1.619 |    0.9483 |
-#> |.....................|    0.6830 |     2.215 |...........|...........|
-#> |    X|     479.16547 |     91.42 |  0.003605 |    0.2859 |    0.1129 |
-#> |.....................|  0.008994 |    0.5931 |     1.121 |   0.05713 |
-#> |.....................|    0.8308 |    0.6865 |     1.619 |    0.9483 |
-#> |.....................|    0.6830 |     2.215 |...........|...........|
-#> |    F| Forward Diff. |     2.367 |    0.6482 |   -0.1602 |  -0.03907 |
-#> |.....................|    0.2347 |   -0.2874 |     1.147 |     1.057 |
-#> |.....................|   -0.4142 |    -2.141 |     1.081 |   -0.1748 |
-#> |.....................|    0.2414 |   -0.4049 |...........|...........|
-#> |  102|     479.16316 |     1.004 |    -1.426 |   -0.9389 |   -0.9187 |
-#> |.....................|    -1.099 |    -1.063 |   -0.1748 |   -0.9208 |
-#> |.....................|   -0.7401 |    -1.113 |   -0.4996 |   -0.8794 |
-#> |.....................|    -1.083 |  -0.04264 |...........|...........|
-#> |    U|     479.16316 |     91.36 |    -5.626 |   -0.9154 |    -2.181 |
-#> |.....................|    -4.711 |    0.3768 |     1.120 |   0.05713 |
-#> |.....................|    0.8310 |    0.6872 |     1.618 |    0.9484 |
-#> |.....................|    0.6829 |     2.215 |...........|...........|
-#> |    X|     479.16316 |     91.36 |  0.003603 |    0.2859 |    0.1129 |
-#> |.....................|  0.008992 |    0.5931 |     1.120 |   0.05713 |
-#> |.....................|    0.8310 |    0.6872 |     1.618 |    0.9484 |
-#> |.....................|    0.6829 |     2.215 |...........|...........|
-#> |    F| Forward Diff. |    -3.810 |    0.6431 |   -0.2376 |  -0.02872 |
-#> |.....................|    0.2384 |   -0.2689 |     1.073 |     1.021 |
-#> |.....................|   -0.4195 |    -2.179 |     2.025 |   -0.6985 |
-#> |.....................|   -0.1403 |   -0.3873 |...........|...........|
-#> |  103|     479.15976 |     1.005 |    -1.427 |   -0.9385 |   -0.9187 |
-#> |.....................|    -1.099 |    -1.063 |   -0.1751 |   -0.9208 |
-#> |.....................|   -0.7399 |    -1.112 |   -0.5000 |   -0.8792 |
-#> |.....................|    -1.083 |  -0.04242 |...........|...........|
-#> |    U|     479.15976 |     91.41 |    -5.627 |   -0.9150 |    -2.181 |
-#> |.....................|    -4.712 |    0.3768 |     1.120 |   0.05713 |
-#> |.....................|    0.8311 |    0.6876 |     1.618 |    0.9486 |
-#> |.....................|    0.6829 |     2.215 |...........|...........|
-#> |    X|     479.15976 |     91.41 |  0.003601 |    0.2860 |    0.1129 |
-#> |.....................|  0.008990 |    0.5931 |     1.120 |   0.05713 |
-#> |.....................|    0.8311 |    0.6876 |     1.618 |    0.9486 |
-#> |.....................|    0.6829 |     2.215 |...........|...........|
-#> |    F| Forward Diff. |     1.385 |    0.6444 |   -0.1513 |  -0.03575 |
-#> |.....................|    0.2363 |   -0.2788 |     1.057 |     1.037 |
-#> |.....................|   -0.4304 |    -2.135 |     1.940 |   -0.6607 |
-#> |.....................|   -0.1552 |   -0.4034 |...........|...........|
-#> |  104|     479.15697 |     1.004 |    -1.427 |   -0.9385 |   -0.9187 |
-#> |.....................|    -1.099 |    -1.063 |   -0.1754 |   -0.9212 |
-#> |.....................|   -0.7397 |    -1.111 |   -0.5007 |   -0.8790 |
-#> |.....................|    -1.083 |  -0.04228 |...........|...........|
-#> |    U|     479.15697 |     91.37 |    -5.627 |   -0.9150 |    -2.181 |
-#> |.....................|    -4.712 |    0.3769 |     1.120 |   0.05712 |
-#> |.....................|    0.8312 |    0.6883 |     1.617 |    0.9488 |
-#> |.....................|    0.6829 |     2.215 |...........|...........|
-#> |    X|     479.15697 |     91.37 |  0.003600 |    0.2860 |    0.1129 |
-#> |.....................|  0.008990 |    0.5931 |     1.120 |   0.05712 |
-#> |.....................|    0.8312 |    0.6883 |     1.617 |    0.9488 |
-#> |.....................|    0.6829 |     2.215 |...........|...........|
-#> |    F| Forward Diff. |    -2.828 |    0.6406 |   -0.2090 |  -0.02895 |
-#> |.....................|    0.2376 |   -0.2659 |     1.059 |    0.9695 |
-#> |.....................|   -0.4112 |    -2.078 |     1.041 |   -0.1304 |
-#> |.....................|    0.2608 |   -0.3859 |...........|...........|
-#> |  105|     479.15524 |     1.005 |    -1.427 |   -0.9384 |   -0.9187 |
-#> |.....................|    -1.099 |    -1.063 |   -0.1758 |   -0.9215 |
-#> |.....................|   -0.7396 |    -1.111 |   -0.5010 |   -0.8789 |
-#> |.....................|    -1.083 |  -0.04216 |...........|...........|
-#> |    U|     479.15524 |     91.45 |    -5.627 |   -0.9149 |    -2.181 |
-#> |.....................|    -4.712 |    0.3769 |     1.120 |   0.05711 |
-#> |.....................|    0.8313 |    0.6888 |     1.617 |    0.9489 |
-#> |.....................|    0.6828 |     2.215 |...........|...........|
-#> |    X|     479.15524 |     91.45 |  0.003599 |    0.2860 |    0.1129 |
-#> |.....................|  0.008989 |    0.5931 |     1.120 |   0.05711 |
-#> |.....................|    0.8313 |    0.6888 |     1.617 |    0.9489 |
-#> |.....................|    0.6828 |     2.215 |...........|...........|
-#> |    F| Forward Diff. |     5.191 |    0.6447 |   -0.1017 |  -0.04048 |
-#> |.....................|    0.2348 |   -0.2858 |     1.095 |     1.009 |
-#> |.....................|   -0.3975 |    -1.983 |     1.956 |   -0.5702 |
-#> |.....................|   -0.1591 |   -0.3996 |...........|...........|
-#> |  106|     479.15192 |     1.004 |    -1.428 |   -0.9381 |   -0.9186 |
-#> |.....................|    -1.100 |    -1.063 |   -0.1760 |   -0.9214 |
-#> |.....................|   -0.7393 |    -1.110 |   -0.5013 |   -0.8787 |
-#> |.....................|    -1.083 |  -0.04194 |...........|...........|
-#> |    U|     479.15192 |     91.38 |    -5.628 |   -0.9146 |    -2.181 |
-#> |.....................|    -4.712 |    0.3770 |     1.120 |   0.05711 |
-#> |.....................|    0.8315 |    0.6892 |     1.616 |    0.9490 |
-#> |.....................|    0.6828 |     2.216 |...........|...........|
-#> |    X|     479.15192 |     91.38 |  0.003597 |    0.2861 |    0.1129 |
-#> |.....................|  0.008987 |    0.5932 |     1.120 |   0.05711 |
-#> |.....................|    0.8315 |    0.6892 |     1.616 |    0.9490 |
-#> |.....................|    0.6828 |     2.216 |...........|...........|
-#> |    F| Forward Diff. |    -1.012 |    0.6390 |   -0.1711 |  -0.03027 |
-#> |.....................|    0.2366 |   -0.2653 |     1.098 |    0.9640 |
-#> |.....................|   -0.4101 |    -2.024 |    0.9749 |   -0.1142 |
-#> |.....................|    0.2645 |   -0.3871 |...........|...........|
-#> |  107|     479.14897 |     1.005 |    -1.428 |   -0.9380 |   -0.9186 |
-#> |.....................|    -1.100 |    -1.063 |   -0.1764 |   -0.9218 |
-#> |.....................|   -0.7392 |    -1.110 |   -0.5017 |   -0.8787 |
-#> |.....................|    -1.083 |  -0.04178 |...........|...........|
-#> |    U|     479.14897 |     91.42 |    -5.628 |   -0.9146 |    -2.181 |
-#> |.....................|    -4.712 |    0.3771 |     1.120 |   0.05710 |
-#> |.....................|    0.8317 |    0.6900 |     1.616 |    0.9491 |
-#> |.....................|    0.6827 |     2.216 |...........|...........|
-#> |    X|     479.14897 |     91.42 |  0.003596 |    0.2861 |    0.1129 |
-#> |.....................|  0.008986 |    0.5932 |     1.120 |   0.05710 |
-#> |.....................|    0.8317 |    0.6900 |     1.616 |    0.9491 |
-#> |.....................|    0.6827 |     2.216 |...........|...........|
-#> |  108|     479.14773 |     1.005 |    -1.428 |   -0.9379 |   -0.9186 |
-#> |.....................|    -1.100 |    -1.062 |   -0.1770 |   -0.9223 |
-#> |.....................|   -0.7390 |    -1.109 |   -0.5022 |   -0.8786 |
-#> |.....................|    -1.083 |  -0.04159 |...........|...........|
-#> |    U|     479.14773 |     91.47 |    -5.628 |   -0.9145 |    -2.181 |
-#> |.....................|    -4.712 |    0.3771 |     1.120 |   0.05708 |
-#> |.....................|    0.8318 |    0.6909 |     1.615 |    0.9491 |
-#> |.....................|    0.6826 |     2.216 |...........|...........|
-#> |    X|     479.14773 |     91.47 |  0.003595 |    0.2861 |    0.1129 |
-#> |.....................|  0.008985 |    0.5932 |     1.120 |   0.05708 |
-#> |.....................|    0.8318 |    0.6909 |     1.615 |    0.9491 |
-#> |.....................|    0.6826 |     2.216 |...........|...........|
-#> |    F| Forward Diff. |     7.333 |    0.6414 |  -0.06030 |  -0.04156 |
-#> |.....................|    0.2338 |   -0.2836 |     1.014 |     1.002 |
-#> |.....................|   -0.3897 |    -1.922 |    0.8816 |   -0.1288 |
-#> |.....................|    0.1940 |   -0.4011 |...........|...........|
-#> |  109|     479.14119 |     1.004 |    -1.430 |   -0.9374 |   -0.9185 |
-#> |.....................|    -1.100 |    -1.062 |   -0.1775 |   -0.9218 |
-#> |.....................|   -0.7383 |    -1.108 |   -0.5019 |   -0.8783 |
-#> |.....................|    -1.083 |  -0.04112 |...........|...........|
-#> |    U|     479.14119 |     91.39 |    -5.630 |   -0.9140 |    -2.181 |
-#> |.....................|    -4.713 |    0.3774 |     1.119 |   0.05710 |
-#> |.....................|    0.8323 |    0.6917 |     1.616 |    0.9495 |
-#> |.....................|    0.6826 |     2.217 |...........|...........|
-#> |    X|     479.14119 |     91.39 |  0.003588 |    0.2862 |    0.1129 |
-#> |.....................|  0.008979 |    0.5933 |     1.119 |   0.05710 |
-#> |.....................|    0.8323 |    0.6917 |     1.616 |    0.9495 |
-#> |.....................|    0.6826 |     2.217 |...........|...........|
-#> |    F| Forward Diff. |   -0.4299 |    0.6321 |   -0.1435 |  -0.02760 |
-#> |.....................|    0.2360 |   -0.2479 |     1.019 |    0.9518 |
-#> |.....................|   -0.3967 |    -1.860 |     1.900 |   -0.5922 |
-#> |.....................|   -0.1599 |   -0.3806 |...........|...........|
-#> |  110|     479.13501 |     1.005 |    -1.431 |   -0.9373 |   -0.9185 |
-#> |.....................|    -1.101 |    -1.062 |   -0.1783 |   -0.9226 |
-#> |.....................|   -0.7379 |    -1.106 |   -0.5035 |   -0.8778 |
-#> |.....................|    -1.083 |  -0.04080 |...........|...........|
-#> |    U|     479.13501 |     91.42 |    -5.631 |   -0.9139 |    -2.181 |
-#> |.....................|    -4.713 |    0.3775 |     1.119 |   0.05707 |
-#> |.....................|    0.8326 |    0.6932 |     1.614 |    0.9500 |
-#> |.....................|    0.6827 |     2.217 |...........|...........|
-#> |    X|     479.13501 |     91.42 |  0.003586 |    0.2862 |    0.1129 |
-#> |.....................|  0.008977 |    0.5933 |     1.119 |   0.05707 |
-#> |.....................|    0.8326 |    0.6932 |     1.614 |    0.9500 |
-#> |.....................|    0.6827 |     2.217 |...........|...........|
-#> |    F| Forward Diff. |     2.960 |    0.6324 |   -0.1010 |  -0.03176 |
-#> |.....................|    0.2344 |   -0.2516 |    0.9454 |    0.8792 |
-#> |.....................|   -0.3822 |    -1.742 |    0.9146 |  -0.04263 |
-#> |.....................|    0.2425 |   -0.3771 |...........|...........|
-#> |  111|     479.13244 |     1.004 |    -1.432 |   -0.9368 |   -0.9184 |
-#> |.....................|    -1.101 |    -1.061 |   -0.1790 |   -0.9224 |
-#> |.....................|   -0.7372 |    -1.105 |   -0.5036 |   -0.8775 |
-#> |.....................|    -1.083 |  -0.04025 |...........|...........|
-#> |    U|     479.13244 |     91.33 |    -5.632 |   -0.9135 |    -2.181 |
-#> |.....................|    -4.714 |    0.3778 |     1.119 |   0.05708 |
-#> |.....................|    0.8331 |    0.6941 |     1.614 |    0.9502 |
-#> |.....................|    0.6825 |     2.218 |...........|...........|
-#> |    X|     479.13244 |     91.33 |  0.003580 |    0.2863 |    0.1130 |
-#> |.....................|  0.008971 |    0.5933 |     1.119 |   0.05708 |
-#> |.....................|    0.8331 |    0.6941 |     1.614 |    0.9502 |
-#> |.....................|    0.6825 |     2.218 |...........|...........|
-#> |    F| Forward Diff. |    -5.808 |    0.6219 |   -0.1958 |  -0.01683 |
-#> |.....................|    0.2369 |   -0.2179 |    0.9347 |    0.8364 |
-#> |.....................|   -0.3987 |    -1.797 |    0.8150 |  -0.05765 |
-#> |.....................|    0.2618 |   -0.3704 |...........|...........|
-#> |  112|     479.12666 |     1.004 |    -1.434 |   -0.9365 |   -0.9183 |
-#> |.....................|    -1.102 |    -1.060 |   -0.1796 |   -0.9220 |
-#> |.....................|   -0.7365 |    -1.104 |   -0.5033 |   -0.8772 |
-#> |.....................|    -1.083 |  -0.03975 |...........|...........|
-#> |    U|     479.12666 |     91.40 |    -5.634 |   -0.9132 |    -2.181 |
-#> |.....................|    -4.714 |    0.3782 |     1.118 |   0.05709 |
-#> |.....................|    0.8336 |    0.6951 |     1.614 |    0.9505 |
-#> |.....................|    0.6824 |     2.218 |...........|...........|
-#> |    X|     479.12666 |     91.40 |  0.003574 |    0.2863 |    0.1130 |
-#> |.....................|  0.008965 |    0.5934 |     1.118 |   0.05709 |
-#> |.....................|    0.8336 |    0.6951 |     1.614 |    0.9505 |
-#> |.....................|    0.6824 |     2.218 |...........|...........|
-#> |    F| Forward Diff. |    0.9955 |    0.6218 |  -0.09617 |  -0.02448 |
-#> |.....................|    0.2342 |   -0.2176 |    0.9924 |    0.8560 |
-#> |.....................|   -0.3772 |    -1.645 |     1.883 |   -0.4422 |
-#> |.....................|   -0.1320 |   -0.3750 |...........|...........|
-#> |  113|     479.12255 |     1.004 |    -1.436 |   -0.9361 |   -0.9182 |
-#> |.....................|    -1.103 |    -1.060 |   -0.1805 |   -0.9221 |
-#> |.....................|   -0.7358 |    -1.103 |   -0.5043 |   -0.8768 |
-#> |.....................|    -1.083 |  -0.03920 |...........|...........|
-#> |    U|     479.12255 |     91.34 |    -5.636 |   -0.9129 |    -2.181 |
-#> |.....................|    -4.715 |    0.3784 |     1.118 |   0.05709 |
-#> |.....................|    0.8341 |    0.6962 |     1.613 |    0.9509 |
-#> |.....................|    0.6824 |     2.219 |...........|...........|
-#> |    X|     479.12255 |     91.34 |  0.003569 |    0.2864 |    0.1130 |
-#> |.....................|  0.008960 |    0.5935 |     1.118 |   0.05709 |
-#> |.....................|    0.8341 |    0.6962 |     1.613 |    0.9509 |
-#> |.....................|    0.6824 |     2.219 |...........|...........|
-#> |    F| Forward Diff. |    -4.522 |    0.6133 |   -0.1571 |  -0.01492 |
-#> |.....................|    0.2353 |   -0.1923 |    0.9045 |    0.7846 |
-#> |.....................|   -0.3572 |    -1.629 |    0.8508 |   0.03564 |
-#> |.....................|    0.2811 |   -0.3561 |...........|...........|
-#> |  114|     479.11855 |     1.005 |    -1.437 |   -0.9356 |   -0.9182 |
-#> |.....................|    -1.103 |    -1.059 |   -0.1812 |   -0.9217 |
-#> |.....................|   -0.7351 |    -1.102 |   -0.5043 |   -0.8766 |
-#> |.....................|    -1.084 |  -0.03859 |...........|...........|
-#> |    U|     479.11855 |     91.41 |    -5.637 |   -0.9124 |    -2.181 |
-#> |.....................|    -4.716 |    0.3787 |     1.118 |   0.05710 |
-#> |.....................|    0.8346 |    0.6968 |     1.613 |    0.9510 |
-#> |.....................|    0.6823 |     2.220 |...........|...........|
-#> |    X|     479.11855 |     91.41 |  0.003562 |    0.2865 |    0.1130 |
-#> |.....................|  0.008953 |    0.5936 |     1.118 |   0.05710 |
-#> |.....................|    0.8346 |    0.6968 |     1.613 |    0.9510 |
-#> |.....................|    0.6823 |     2.220 |...........|...........|
-#> |    F| Forward Diff. |     2.813 |    0.6131 |  -0.03713 |  -0.02450 |
-#> |.....................|    0.2319 |   -0.1976 |    0.8863 |    0.8390 |
-#> |.....................|   -0.3589 |    -1.516 |    0.8806 |   -0.4426 |
-#> |.....................|   -0.1647 |   -0.3784 |...........|...........|
-#> |  115|     479.11487 |     1.004 |    -1.439 |   -0.9352 |   -0.9181 |
-#> |.....................|    -1.104 |    -1.058 |   -0.1819 |   -0.9213 |
-#> |.....................|   -0.7344 |    -1.101 |   -0.5040 |   -0.8763 |
-#> |.....................|    -1.084 |  -0.03810 |...........|...........|
-#> |    U|     479.11487 |     91.37 |    -5.639 |   -0.9121 |    -2.180 |
-#> |.....................|    -4.716 |    0.3790 |     1.117 |   0.05711 |
-#> |.....................|    0.8352 |    0.6977 |     1.613 |    0.9514 |
-#> |.....................|    0.6823 |     2.220 |...........|...........|
-#> |    X|     479.11487 |     91.37 |  0.003555 |    0.2866 |    0.1130 |
-#> |.....................|  0.008947 |    0.5936 |     1.117 |   0.05711 |
-#> |.....................|    0.8352 |    0.6977 |     1.613 |    0.9514 |
-#> |.....................|    0.6823 |     2.220 |...........|...........|
-#> |    F| Forward Diff. |    -1.684 |    0.6054 |  -0.08346 |  -0.01559 |
-#> |.....................|    0.2328 |   -0.1708 |    0.9518 |    0.8099 |
-#> |.....................|   -0.3621 |    -1.485 |    0.9267 |   -0.3776 |
-#> |.....................|   -0.1041 |   -0.3537 |...........|...........|
-#> |  116|     479.11139 |     1.005 |    -1.441 |   -0.9347 |   -0.9181 |
-#> |.....................|    -1.105 |    -1.058 |   -0.1829 |   -0.9211 |
-#> |.....................|   -0.7337 |    -1.100 |   -0.5039 |   -0.8760 |
-#> |.....................|    -1.083 |  -0.03771 |...........|...........|
-#> |    U|     479.11139 |     91.41 |    -5.641 |   -0.9117 |    -2.180 |
-#> |.....................|    -4.717 |    0.3792 |     1.117 |   0.05712 |
-#> |.....................|    0.8357 |    0.6988 |     1.613 |    0.9517 |
-#> |.....................|    0.6824 |     2.221 |...........|...........|
-#> |    X|     479.11139 |     91.41 |  0.003549 |    0.2867 |    0.1130 |
-#> |.....................|  0.008941 |    0.5937 |     1.117 |   0.05712 |
-#> |.....................|    0.8357 |    0.6988 |     1.613 |    0.9517 |
-#> |.....................|    0.6824 |     2.221 |...........|...........|
-#> |    F| Forward Diff. |     3.241 |    0.6036 | 0.0009951 |  -0.02154 |
-#> |.....................|    0.2300 |   -0.1727 |    0.8524 |    0.8311 |
-#> |.....................|   -0.3642 |    -1.386 |     1.866 |   -0.3472 |
-#> |.....................|   -0.1024 |   -0.3634 |...........|...........|
-#> |  117|     479.10851 |     1.004 |    -1.443 |   -0.9342 |   -0.9180 |
-#> |.....................|    -1.105 |    -1.058 |   -0.1837 |   -0.9207 |
-#> |.....................|   -0.7329 |    -1.100 |   -0.5043 |   -0.8759 |
-#> |.....................|    -1.084 |  -0.03710 |...........|...........|
-#> |    U|     479.10851 |     91.37 |    -5.643 |   -0.9112 |    -2.180 |
-#> |.....................|    -4.718 |    0.3794 |     1.117 |   0.05713 |
-#> |.....................|    0.8363 |    0.6988 |     1.613 |    0.9517 |
-#> |.....................|    0.6823 |     2.222 |...........|...........|
-#> |    X|     479.10851 |     91.37 |  0.003542 |    0.2868 |    0.1130 |
-#> |.....................|  0.008933 |    0.5937 |     1.117 |   0.05713 |
-#> |.....................|    0.8363 |    0.6988 |     1.613 |    0.9517 |
-#> |.....................|    0.6823 |     2.222 |...........|...........|
-#> |    F| Forward Diff. |    -1.500 |    0.5956 |  -0.03344 |  -0.01385 |
-#> |.....................|    0.2306 |   -0.1498 |    0.8910 |    0.8240 |
-#> |.....................|   -0.3570 |    -1.405 |    0.8461 |   -0.3572 |
-#> |.....................|  -0.08808 |   -0.3487 |...........|...........|
-#> |  118|     479.10606 |     1.005 |    -1.445 |   -0.9338 |   -0.9180 |
-#> |.....................|    -1.106 |    -1.057 |   -0.1846 |   -0.9207 |
-#> |.....................|   -0.7320 |    -1.099 |   -0.5047 |   -0.8757 |
-#> |.....................|    -1.084 |  -0.03650 |...........|...........|
-#> |    U|     479.10606 |     91.43 |    -5.645 |   -0.9108 |    -2.180 |
-#> |.....................|    -4.719 |    0.3796 |     1.116 |   0.05713 |
-#> |.....................|    0.8369 |    0.6994 |     1.612 |    0.9519 |
-#> |.....................|    0.6822 |     2.222 |...........|...........|
-#> |    X|     479.10606 |     91.43 |  0.003535 |    0.2868 |    0.1130 |
-#> |.....................|  0.008927 |    0.5938 |     1.116 |   0.05713 |
-#> |.....................|    0.8369 |    0.6994 |     1.612 |    0.9519 |
-#> |.....................|    0.6822 |     2.222 |...........|...........|
-#> |    F| Forward Diff. |     5.260 |    0.5953 |   0.07226 |  -0.02302 |
-#> |.....................|    0.2275 |   -0.1573 |    0.8150 |    0.8159 |
-#> |.....................|   -0.3410 |    -1.340 |    0.8208 |    0.1422 |
-#> |.....................|    0.2750 |   -0.3500 |...........|...........|
-#> |  119|     479.10199 |     1.004 |    -1.447 |   -0.9337 |   -0.9181 |
-#> |.....................|    -1.107 |    -1.057 |   -0.1854 |   -0.9204 |
-#> |.....................|   -0.7311 |    -1.099 |   -0.5045 |   -0.8757 |
-#> |.....................|    -1.084 |  -0.03604 |...........|...........|
-#> |    U|     479.10199 |     91.37 |    -5.647 |   -0.9107 |    -2.180 |
-#> |.....................|    -4.720 |    0.3799 |     1.116 |   0.05714 |
-#> |.....................|    0.8375 |    0.6999 |     1.613 |    0.9520 |
-#> |.....................|    0.6821 |     2.223 |...........|...........|
-#> |    X|     479.10199 |     91.37 |  0.003528 |    0.2869 |    0.1130 |
-#> |.....................|  0.008919 |    0.5938 |     1.116 |   0.05714 |
-#> |.....................|    0.8375 |    0.6999 |     1.613 |    0.9520 |
-#> |.....................|    0.6821 |     2.223 |...........|...........|
-#> |    F| Forward Diff. |   -0.7698 |    0.5858 | -0.004343 |  -0.01418 |
-#> |.....................|    0.2278 |   -0.1298 |    0.8244 |    0.7686 |
-#> |.....................|   -0.3575 |    -1.372 |    0.8320 |   -0.3359 |
-#> |.....................|    0.2977 |   -0.3384 |...........|...........|
-#> |  120|     479.09844 |     1.005 |    -1.448 |   -0.9337 |   -0.9180 |
-#> |.....................|    -1.108 |    -1.056 |   -0.1863 |   -0.9208 |
-#> |.....................|   -0.7304 |    -1.097 |   -0.5051 |   -0.8752 |
-#> |.....................|    -1.084 |  -0.03534 |...........|...........|
-#> |    U|     479.09844 |     91.43 |    -5.648 |   -0.9108 |    -2.180 |
-#> |.....................|    -4.720 |    0.3801 |     1.116 |   0.05713 |
-#> |.....................|    0.8381 |    0.7011 |     1.612 |    0.9524 |
-#> |.....................|    0.6817 |     2.224 |...........|...........|
-#> |    X|     479.09844 |     91.43 |  0.003523 |    0.2868 |    0.1130 |
-#> |.....................|  0.008914 |    0.5939 |     1.116 |   0.05713 |
-#> |.....................|    0.8381 |    0.7011 |     1.612 |    0.9524 |
-#> |.....................|    0.6817 |     2.224 |...........|...........|
-#> |    F| Forward Diff. |     4.894 |    0.5851 |   0.05981 |  -0.02077 |
-#> |.....................|    0.2261 |   -0.1389 |    0.7622 |    0.7617 |
-#> |.....................|   -0.3411 |    -1.236 |    0.7863 |    0.1583 |
-#> |.....................|    0.2091 |   -0.3951 |...........|...........|
-#> |  121|     479.09485 |     1.004 |    -1.450 |   -0.9338 |   -0.9180 |
-#> |.....................|    -1.108 |    -1.056 |   -0.1867 |   -0.9202 |
-#> |.....................|   -0.7295 |    -1.097 |   -0.5051 |   -0.8750 |
-#> |.....................|    -1.085 |  -0.03445 |...........|...........|
-#> |    U|     479.09485 |     91.37 |    -5.650 |   -0.9108 |    -2.180 |
-#> |.....................|    -4.721 |    0.3803 |     1.116 |   0.05714 |
-#> |.....................|    0.8388 |    0.7016 |     1.612 |    0.9526 |
-#> |.....................|    0.6813 |     2.225 |...........|...........|
-#> |    X|     479.09485 |     91.37 |  0.003517 |    0.2868 |    0.1130 |
-#> |.....................|  0.008907 |    0.5939 |     1.116 |   0.05714 |
-#> |.....................|    0.8388 |    0.7016 |     1.612 |    0.9526 |
-#> |.....................|    0.6813 |     2.225 |...........|...........|
-#> |    F| Forward Diff. |    -1.077 |    0.5762 |  -0.02502 |  -0.01122 |
-#> |.....................|    0.2275 |   -0.1137 |    0.7953 |    0.7347 |
-#> |.....................|   -0.3473 |    -1.249 |    0.8683 |    0.1895 |
-#> |.....................|    0.2333 |   -0.3625 |...........|...........|
-#> |  122|     479.09211 |     1.005 |    -1.452 |   -0.9337 |   -0.9180 |
-#> |.....................|    -1.109 |    -1.055 |   -0.1878 |   -0.9202 |
-#> |.....................|   -0.7286 |    -1.096 |   -0.5055 |   -0.8752 |
-#> |.....................|    -1.085 |  -0.03372 |...........|...........|
-#> |    U|     479.09211 |     91.41 |    -5.652 |   -0.9107 |    -2.180 |
-#> |.....................|    -4.722 |    0.3805 |     1.115 |   0.05714 |
-#> |.....................|    0.8394 |    0.7021 |     1.612 |    0.9524 |
-#> |.....................|    0.6810 |     2.226 |...........|...........|
-#> |    X|     479.09211 |     91.41 |  0.003510 |    0.2868 |    0.1130 |
-#> |.....................|  0.008900 |    0.5940 |     1.115 |   0.05714 |
-#> |.....................|    0.8394 |    0.7021 |     1.612 |    0.9524 |
-#> |.....................|    0.6810 |     2.226 |...........|...........|
-#> |    F| Forward Diff. |     3.651 |    0.5754 |   0.04071 |  -0.01634 |
-#> |.....................|    0.2261 |   -0.1150 |    0.8084 |    0.7089 |
-#> |.....................|   -0.3268 |    -1.156 |    0.8610 |    0.1793 |
-#> |.....................|    0.2137 |   -0.3471 |...........|...........|
-#> |  123|     479.08947 |     1.004 |    -1.454 |   -0.9335 |   -0.9181 |
-#> |.....................|    -1.110 |    -1.055 |   -0.1890 |   -0.9199 |
-#> |.....................|   -0.7277 |    -1.096 |   -0.5056 |   -0.8754 |
-#> |.....................|    -1.085 |  -0.03307 |...........|...........|
-#> |    U|     479.08947 |     91.37 |    -5.654 |   -0.9105 |    -2.180 |
-#> |.....................|    -4.722 |    0.3808 |     1.115 |   0.05715 |
-#> |.....................|    0.8401 |    0.7021 |     1.611 |    0.9522 |
-#> |.....................|    0.6809 |     2.226 |...........|...........|
-#> |    X|     479.08947 |     91.37 |  0.003504 |    0.2869 |    0.1130 |
-#> |.....................|  0.008893 |    0.5941 |     1.115 |   0.05715 |
-#> |.....................|    0.8401 |    0.7021 |     1.611 |    0.9522 |
-#> |.....................|    0.6809 |     2.226 |...........|...........|
-#> |    F| Forward Diff. |   -0.8529 |    0.5679 | -0.006947 | -0.009666 |
-#> |.....................|    0.2263 |  -0.09399 |    0.7582 |    0.6848 |
-#> |.....................|   -0.3382 |    -1.232 |    0.7736 |   -0.3452 |
-#> |.....................|   -0.1950 |   -0.3796 |...........|...........|
-#> |  124|     479.08673 |     1.005 |    -1.456 |   -0.9331 |   -0.9181 |
-#> |.....................|    -1.111 |    -1.054 |   -0.1901 |   -0.9198 |
-#> |.....................|   -0.7269 |    -1.095 |   -0.5060 |   -0.8751 |
-#> |.....................|    -1.085 |  -0.03242 |...........|...........|
-#> |    U|     479.08673 |     91.42 |    -5.656 |   -0.9102 |    -2.180 |
-#> |.....................|    -4.723 |    0.3808 |     1.114 |   0.05716 |
-#> |.....................|    0.8406 |    0.7030 |     1.611 |    0.9525 |
-#> |.....................|    0.6810 |     2.227 |...........|...........|
-#> |    X|     479.08673 |     91.42 |  0.003498 |    0.2870 |    0.1130 |
-#> |.....................|  0.008887 |    0.5941 |     1.114 |   0.05716 |
-#> |.....................|    0.8406 |    0.7030 |     1.611 |    0.9525 |
-#> |.....................|    0.6810 |     2.227 |...........|...........|
-#> |    F| Forward Diff. |     4.055 |    0.5667 |   0.07240 |  -0.01542 |
-#> |.....................|    0.2241 |   -0.1033 |    0.7160 |    0.6904 |
-#> |.....................|   -0.3260 |    -1.123 |    0.7675 |    0.1856 |
-#> |.....................|    0.1986 |   -0.4973 |...........|...........|
-#> |  125|     479.08385 |     1.004 |    -1.457 |   -0.9328 |   -0.9181 |
-#> |.....................|    -1.112 |    -1.054 |   -0.1908 |   -0.9191 |
-#> |.....................|   -0.7261 |    -1.095 |   -0.5059 |   -0.8749 |
-#> |.....................|    -1.085 |  -0.03140 |...........|...........|
-#> |    U|     479.08385 |     91.37 |    -5.657 |   -0.9100 |    -2.180 |
-#> |.....................|    -4.724 |    0.3808 |     1.114 |   0.05718 |
-#> |.....................|    0.8412 |    0.7034 |     1.611 |    0.9527 |
-#> |.....................|    0.6808 |     2.228 |...........|...........|
-#> |    X|     479.08385 |     91.37 |  0.003491 |    0.2870 |    0.1130 |
-#> |.....................|  0.008879 |    0.5941 |     1.114 |   0.05718 |
-#> |.....................|    0.8412 |    0.7034 |     1.611 |    0.9527 |
-#> |.....................|    0.6808 |     2.228 |...........|...........|
-#> |    F| Forward Diff. |   -0.7735 |    0.5583 |   0.01997 | -0.008335 |
-#> |.....................|    0.2243 |  -0.08958 |    0.6952 |    0.6337 |
-#> |.....................|   -0.3199 |    -1.102 |    0.8222 |    0.2014 |
-#> |.....................|    0.2310 |   -0.4538 |...........|...........|
-#> |  126|     479.08143 |     1.005 |    -1.459 |   -0.9328 |   -0.9181 |
-#> |.....................|    -1.112 |    -1.054 |   -0.1918 |   -0.9191 |
-#> |.....................|   -0.7254 |    -1.094 |   -0.5066 |   -0.8749 |
-#> |.....................|    -1.086 |  -0.03018 |...........|...........|
-#> |    U|     479.08143 |     91.42 |    -5.659 |   -0.9100 |    -2.180 |
-#> |.....................|    -4.725 |    0.3810 |     1.113 |   0.05718 |
-#> |.....................|    0.8417 |    0.7042 |     1.610 |    0.9527 |
-#> |.....................|    0.6804 |     2.230 |...........|...........|
-#> |    X|     479.08143 |     91.42 |  0.003486 |    0.2870 |    0.1130 |
-#> |.....................|  0.008874 |    0.5941 |     1.113 |   0.05718 |
-#> |.....................|    0.8417 |    0.7042 |     1.610 |    0.9527 |
-#> |.....................|    0.6804 |     2.230 |...........|...........|
-#> |    F| Forward Diff. |     4.589 |    0.5568 |   0.08446 |  -0.01637 |
-#> |.....................|    0.2217 |  -0.09943 |    0.6530 |    0.6713 |
-#> |.....................|   -0.3160 |    -1.044 |    0.6971 |   -0.3035 |
-#> |.....................|   -0.2323 |   -0.3746 |...........|...........|
-#> |  127|     479.07858 |     1.004 |    -1.461 |   -0.9326 |   -0.9181 |
-#> |.....................|    -1.113 |    -1.054 |   -0.1923 |   -0.9184 |
-#> |.....................|   -0.7246 |    -1.093 |   -0.5066 |   -0.8747 |
-#> |.....................|    -1.086 |  -0.02916 |...........|...........|
-#> |    U|     479.07858 |     91.36 |    -5.661 |   -0.9098 |    -2.181 |
-#> |.....................|    -4.725 |    0.3811 |     1.113 |   0.05720 |
-#> |.....................|    0.8423 |    0.7045 |     1.610 |    0.9529 |
-#> |.....................|    0.6802 |     2.231 |...........|...........|
-#> |    X|     479.07858 |     91.36 |  0.003479 |    0.2870 |    0.1130 |
-#> |.....................|  0.008866 |    0.5941 |     1.113 |   0.05720 |
-#> |.....................|    0.8423 |    0.7045 |     1.610 |    0.9529 |
-#> |.....................|    0.6802 |     2.231 |...........|...........|
-#> |    F| Forward Diff. |    -1.147 |    0.5485 |   0.01974 | -0.006990 |
-#> |.....................|    0.2231 |  -0.08394 |    0.6583 |    0.6424 |
-#> |.....................|   -0.3232 |    -1.114 |    0.8219 |    0.1886 |
-#> |.....................|    0.1911 |   -0.3375 |...........|...........|
-#> |  128|     479.07618 |     1.004 |    -1.463 |   -0.9323 |   -0.9182 |
-#> |.....................|    -1.114 |    -1.054 |   -0.1929 |   -0.9181 |
-#> |.....................|   -0.7237 |    -1.093 |   -0.5068 |   -0.8746 |
-#> |.....................|    -1.086 |  -0.02850 |...........|...........|
-#> |    U|     479.07618 |     91.40 |    -5.663 |   -0.9095 |    -2.181 |
-#> |.....................|    -4.726 |    0.3811 |     1.113 |   0.05721 |
-#> |.....................|    0.8430 |    0.7050 |     1.610 |    0.9530 |
-#> |.....................|    0.6800 |     2.232 |...........|...........|
-#> |    X|     479.07618 |     91.40 |  0.003472 |    0.2871 |    0.1130 |
-#> |.....................|  0.008858 |    0.5941 |     1.113 |   0.05721 |
-#> |.....................|    0.8430 |    0.7050 |     1.610 |    0.9530 |
-#> |.....................|    0.6800 |     2.232 |...........|...........|
-#> |    F| Forward Diff. |     2.586 |    0.5458 |   0.07904 |  -0.01251 |
-#> |.....................|    0.2203 |  -0.08960 |    0.6458 |    0.6586 |
-#> |.....................|   -0.3031 |   -0.9906 |    0.7687 |    0.2646 |
-#> |.....................|    0.1721 |   -0.3284 |...........|...........|
-#> |  129|     479.07405 |     1.004 |    -1.465 |   -0.9322 |   -0.9183 |
-#> |.....................|    -1.115 |    -1.053 |   -0.1937 |   -0.9179 |
-#> |.....................|   -0.7228 |    -1.093 |   -0.5070 |   -0.8747 |
-#> |.....................|    -1.087 |  -0.02798 |...........|...........|
-#> |    U|     479.07405 |     91.36 |    -5.665 |   -0.9094 |    -2.181 |
-#> |.....................|    -4.727 |    0.3813 |     1.113 |   0.05721 |
-#> |.....................|    0.8437 |    0.7050 |     1.610 |    0.9529 |
-#> |.....................|    0.6797 |     2.233 |...........|...........|
-#> |    X|     479.07405 |     91.36 |  0.003465 |    0.2871 |    0.1130 |
-#> |.....................|  0.008850 |    0.5942 |     1.113 |   0.05721 |
-#> |.....................|    0.8437 |    0.7050 |     1.610 |    0.9529 |
-#> |.....................|    0.6797 |     2.233 |...........|...........|
-#> |    F| Forward Diff. |    -1.296 |    0.5389 |   0.03360 | -0.006173 |
-#> |.....................|    0.2208 |  -0.07255 |    0.6853 |    0.5995 |
-#> |.....................|   -0.2906 |    -1.015 |    0.7685 |    0.2327 |
-#> |.....................|    0.1765 |   -0.3245 |...........|...........|
-#> |  130|     479.07209 |     1.004 |    -1.467 |   -0.9321 |   -0.9183 |
-#> |.....................|    -1.116 |    -1.053 |   -0.1949 |   -0.9178 |
-#> |.....................|   -0.7220 |    -1.093 |   -0.5073 |   -0.8750 |
-#> |.....................|    -1.087 |  -0.02746 |...........|...........|
-#> |    U|     479.07209 |     91.39 |    -5.667 |   -0.9093 |    -2.181 |
-#> |.....................|    -4.728 |    0.3814 |     1.112 |   0.05721 |
-#> |.....................|    0.8442 |    0.7050 |     1.609 |    0.9526 |
-#> |.....................|    0.6796 |     2.233 |...........|...........|
-#> |    X|     479.07209 |     91.39 |  0.003458 |    0.2871 |    0.1130 |
-#> |.....................|  0.008841 |    0.5942 |     1.112 |   0.05721 |
-#> |.....................|    0.8442 |    0.7050 |     1.609 |    0.9526 |
-#> |.....................|    0.6796 |     2.233 |...........|...........|
-#> |    F| Forward Diff. |     2.160 |    0.5372 |   0.08826 |  -0.01153 |
-#> |.....................|    0.2184 |  -0.07756 |    0.6386 |    0.6404 |
-#> |.....................|   -0.2977 |   -0.9812 |    0.7463 |    0.2047 |
-#> |.....................|    0.1647 |   -0.3238 |...........|...........|
-#> |  131|     479.07029 |     1.004 |    -1.469 |   -0.9320 |   -0.9184 |
-#> |.....................|    -1.117 |    -1.053 |   -0.1960 |   -0.9175 |
-#> |.....................|   -0.7213 |    -1.093 |   -0.5075 |   -0.8752 |
-#> |.....................|    -1.087 |  -0.02689 |...........|...........|
-#> |    U|     479.07029 |     91.35 |    -5.669 |   -0.9092 |    -2.181 |
-#> |.....................|    -4.729 |    0.3815 |     1.112 |   0.05722 |
-#> |.....................|    0.8447 |    0.7049 |     1.609 |    0.9524 |
-#> |.....................|    0.6795 |     2.234 |...........|...........|
-#> |    X|     479.07029 |     91.35 |  0.003451 |    0.2872 |    0.1130 |
-#> |.....................|  0.008833 |    0.5942 |     1.112 |   0.05722 |
-#> |.....................|    0.8447 |    0.7049 |     1.609 |    0.9524 |
-#> |.....................|    0.6795 |     2.234 |...........|...........|
-#> |    F| Forward Diff. |    -1.487 |    0.5301 |   0.04502 | -0.006786 |
-#> |.....................|    0.2180 |  -0.06576 |    0.6433 |    0.5523 |
-#> |.....................|   -0.2822 |    -1.039 |     1.637 |   -0.2973 |
-#> |.....................|   -0.2152 |   -0.3175 |...........|...........|
-#> |  132|     479.06833 |     1.004 |    -1.471 |   -0.9316 |   -0.9185 |
-#> |.....................|    -1.118 |    -1.053 |   -0.1965 |   -0.9170 |
-#> |.....................|   -0.7207 |    -1.093 |   -0.5082 |   -0.8751 |
-#> |.....................|    -1.087 |  -0.02616 |...........|...........|
-#> |    U|     479.06833 |     91.38 |    -5.671 |   -0.9088 |    -2.181 |
-#> |.....................|    -4.730 |    0.3814 |     1.111 |   0.05724 |
-#> |.....................|    0.8452 |    0.7048 |     1.608 |    0.9525 |
-#> |.....................|    0.6792 |     2.235 |...........|...........|
-#> |    X|     479.06833 |     91.38 |  0.003444 |    0.2872 |    0.1129 |
-#> |.....................|  0.008825 |    0.5942 |     1.111 |   0.05724 |
-#> |.....................|    0.8452 |    0.7048 |     1.608 |    0.9525 |
-#> |.....................|    0.6792 |     2.235 |...........|...........|
-#> |    F| Forward Diff. |    0.6466 |    0.5255 |   0.09166 |  -0.01288 |
-#> |.....................|    0.2142 |  -0.07904 |    0.5622 |    0.5865 |
-#> |.....................|   -0.2779 |    -1.008 |    0.7011 |    0.1998 |
-#> |.....................|    0.1404 |   -0.3181 |...........|...........|
-#> |  133|     479.06868 |     1.003 |    -1.472 |   -0.9317 |   -0.9185 |
-#> |.....................|    -1.118 |    -1.053 |   -0.1973 |   -0.9180 |
-#> |.....................|   -0.7202 |    -1.092 |   -0.5093 |   -0.8754 |
-#> |.....................|    -1.087 |  -0.02567 |...........|...........|
-#> |    U|     479.06868 |     91.29 |    -5.672 |   -0.9090 |    -2.181 |
-#> |.....................|    -4.731 |    0.3814 |     1.111 |   0.05721 |
-#> |.....................|    0.8455 |    0.7062 |     1.607 |    0.9522 |
-#> |.....................|    0.6790 |     2.235 |...........|...........|
-#> |    X|     479.06868 |     91.29 |  0.003441 |    0.2872 |    0.1129 |
-#> |.....................|  0.008822 |    0.5942 |     1.111 |   0.05721 |
-#> |.....................|    0.8455 |    0.7062 |     1.607 |    0.9522 |
-#> |.....................|    0.6790 |     2.235 |...........|...........|
-#> |  134|     479.06735 |     1.004 |    -1.472 |   -0.9316 |   -0.9185 |
-#> |.....................|    -1.118 |    -1.053 |   -0.1969 |   -0.9175 |
-#> |.....................|   -0.7205 |    -1.092 |   -0.5087 |   -0.8753 |
-#> |.....................|    -1.087 |  -0.02593 |...........|...........|
-#> |    U|     479.06735 |     91.33 |    -5.672 |   -0.9089 |    -2.181 |
-#> |.....................|    -4.730 |    0.3814 |     1.111 |   0.05722 |
-#> |.....................|    0.8453 |    0.7054 |     1.608 |    0.9523 |
-#> |.....................|    0.6791 |     2.235 |...........|...........|
-#> |    X|     479.06735 |     91.33 |  0.003443 |    0.2872 |    0.1129 |
-#> |.....................|  0.008823 |    0.5942 |     1.111 |   0.05722 |
-#> |.....................|    0.8453 |    0.7054 |     1.608 |    0.9523 |
-#> |.....................|    0.6791 |     2.235 |...........|...........|
-#> |    F| Forward Diff. |    -3.476 |    0.5223 |   0.03269 | -0.003763 |
-#> |.....................|    0.2173 |  -0.06616 |    0.5281 |    0.5229 |
-#> |.....................|   -0.3041 |    -1.023 |     1.607 |   -0.2773 |
-#> |.....................|   -0.2325 |   -0.3192 |...........|...........|
-#> |  135|     479.06543 |     1.004 |    -1.472 |   -0.9319 |   -0.9185 |
-#> |.....................|    -1.118 |    -1.053 |   -0.1968 |   -0.9175 |
-#> |.....................|   -0.7201 |    -1.092 |   -0.5088 |   -0.8751 |
-#> |.....................|    -1.088 |  -0.02567 |...........|...........|
-#> |    U|     479.06543 |     91.36 |    -5.672 |   -0.9091 |    -2.181 |
-#> |.....................|    -4.731 |    0.3815 |     1.111 |   0.05722 |
-#> |.....................|    0.8456 |    0.7056 |     1.608 |    0.9525 |
-#> |.....................|    0.6790 |     2.235 |...........|...........|
-#> |    X|     479.06543 |     91.36 |  0.003439 |    0.2872 |    0.1129 |
-#> |.....................|  0.008820 |    0.5942 |     1.111 |   0.05722 |
-#> |.....................|    0.8456 |    0.7056 |     1.608 |    0.9525 |
-#> |.....................|    0.6790 |     2.235 |...........|...........|
-#> |  136|     479.06390 |     1.004 |    -1.474 |   -0.9324 |   -0.9185 |
-#> |.....................|    -1.119 |    -1.053 |   -0.1965 |   -0.9174 |
-#> |.....................|   -0.7194 |    -1.092 |   -0.5089 |   -0.8750 |
-#> |.....................|    -1.088 |  -0.02528 |...........|...........|
-#> |    U|      479.0639 |     91.36 |    -5.674 |   -0.9095 |    -2.181 |
-#> |.....................|    -4.732 |    0.3816 |     1.111 |   0.05723 |
-#> |.....................|    0.8461 |    0.7059 |     1.607 |    0.9526 |
-#> |.....................|    0.6786 |     2.236 |...........|...........|
-#> |    X|      479.0639 |     91.36 |  0.003434 |    0.2871 |    0.1129 |
-#> |.....................|  0.008813 |    0.5943 |     1.111 |   0.05723 |
-#> |.....................|    0.8461 |    0.7059 |     1.607 |    0.9526 |
-#> |.....................|    0.6786 |     2.236 |...........|...........|
-#> |  137|     479.05708 |     1.004 |    -1.481 |   -0.9346 |   -0.9186 |
-#> |.....................|    -1.123 |    -1.051 |   -0.1952 |   -0.9171 |
-#> |.....................|   -0.7164 |    -1.090 |   -0.5089 |   -0.8741 |
-#> |.....................|    -1.090 |  -0.02338 |...........|...........|
-#> |    U|     479.05708 |     91.37 |    -5.681 |   -0.9115 |    -2.181 |
-#> |.....................|    -4.735 |    0.3824 |     1.112 |   0.05724 |
-#> |.....................|    0.8483 |    0.7072 |     1.607 |    0.9535 |
-#> |.....................|    0.6769 |     2.238 |...........|...........|
-#> |    X|     479.05708 |     91.37 |  0.003409 |    0.2867 |    0.1129 |
-#> |.....................|  0.008783 |    0.5944 |     1.112 |   0.05724 |
-#> |.....................|    0.8483 |    0.7072 |     1.607 |    0.9535 |
-#> |.....................|    0.6769 |     2.238 |...........|...........|
-#> |  138|     479.03987 |     1.004 |    -1.510 |   -0.9434 |   -0.9188 |
-#> |.....................|    -1.136 |    -1.045 |   -0.1899 |   -0.9157 |
-#> |.....................|   -0.7043 |    -1.085 |   -0.5092 |   -0.8705 |
-#> |.....................|    -1.098 |  -0.01577 |...........|...........|
-#> |    U|     479.03987 |     91.37 |    -5.710 |   -0.9193 |    -2.181 |
-#> |.....................|    -4.749 |    0.3852 |     1.114 |   0.05728 |
-#> |.....................|    0.8571 |    0.7123 |     1.607 |    0.9569 |
-#> |.....................|    0.6702 |     2.247 |...........|...........|
-#> |    X|     479.03987 |     91.37 |  0.003311 |    0.2851 |    0.1129 |
-#> |.....................|  0.008662 |    0.5951 |     1.114 |   0.05728 |
-#> |.....................|    0.8571 |    0.7123 |     1.607 |    0.9569 |
-#> |.....................|    0.6702 |     2.247 |...........|...........|
-#> |    F| Forward Diff. |   -0.3651 |    0.4285 |   -0.5283 | -0.001988 |
-#> |.....................|    0.1991 |   0.06799 |    0.8278 |    0.7155 |
-#> |.....................|   -0.2362 |   -0.3851 |    0.6274 |    0.1204 |
-#> |.....................|   -0.9270 |   -0.3308 |...........|...........|
-#> |  139|     479.01407 |     1.005 |    -1.553 |   -0.9371 |   -0.9187 |
-#> |.....................|    -1.158 |    -1.041 |   -0.1978 |   -0.9162 |
-#> |.....................|   -0.6881 |    -1.086 |   -0.5088 |   -0.8721 |
-#> |.....................|    -1.097 |  -0.01436 |...........|...........|
-#> |    U|     479.01407 |     91.44 |    -5.753 |   -0.9138 |    -2.181 |
-#> |.....................|    -4.770 |    0.3869 |     1.111 |   0.05726 |
-#> |.....................|    0.8690 |    0.7117 |     1.608 |    0.9554 |
-#> |.....................|    0.6704 |     2.249 |...........|...........|
-#> |    X|     479.01407 |     91.44 |  0.003172 |    0.2862 |    0.1129 |
-#> |.....................|  0.008479 |    0.5955 |     1.111 |   0.05726 |
-#> |.....................|    0.8690 |    0.7117 |     1.608 |    0.9554 |
-#> |.....................|    0.6704 |     2.249 |...........|...........|
-#> |    F| Forward Diff. |     7.322 |    0.3385 |  -0.09736 | -0.005783 |
-#> |.....................|    0.1607 |    0.1322 |    0.5556 |    0.5176 |
-#> |.....................|   -0.1562 |   -0.2690 |     1.549 |  -0.03161 |
-#> |.....................|   -0.8578 |   -0.3240 |...........|...........|
-#> |  140|     478.99946 |     1.003 |    -1.595 |   -0.9294 |   -0.9194 |
-#> |.....................|    -1.179 |    -1.045 |   -0.1992 |   -0.9136 |
-#> |.....................|   -0.6715 |    -1.093 |   -0.5132 |   -0.8724 |
-#> |.....................|    -1.100 | -0.009543 |...........|...........|
-#> |    U|     478.99946 |     91.31 |    -5.795 |   -0.9069 |    -2.182 |
-#> |.....................|    -4.791 |    0.3851 |     1.110 |   0.05734 |
-#> |.....................|    0.8811 |    0.7049 |     1.602 |    0.9551 |
-#> |.....................|    0.6678 |     2.255 |...........|...........|
-#> |    X|     478.99946 |     91.31 |  0.003042 |    0.2876 |    0.1128 |
-#> |.....................|  0.008303 |    0.5951 |     1.110 |   0.05734 |
-#> |.....................|    0.8811 |    0.7049 |     1.602 |    0.9551 |
-#> |.....................|    0.6678 |     2.255 |...........|...........|
-#> |    F| Forward Diff. |    -5.440 |    0.2525 |    0.1677 |  0.001517 |
-#> |.....................|    0.1272 |   0.05864 |    0.6253 |    0.4352 |
-#> |.....................|   -0.1457 |   -0.7321 |     1.353 | 0.0009973 |
-#> |.....................|    -1.018 |   -0.3498 |...........|...........|
-#> |  141|     479.00064 |     1.004 |    -1.626 |   -0.9429 |   -0.9240 |
-#> |.....................|    -1.201 |    -1.064 |   -0.2165 |   -0.9169 |
-#> |.....................|   -0.6612 |    -1.100 |   -0.5189 |   -0.8809 |
-#> |.....................|    -1.100 | -0.001744 |...........|...........|
-#> |    U|     479.00064 |     91.38 |    -5.826 |   -0.9189 |    -2.186 |
-#> |.....................|    -4.814 |    0.3763 |     1.103 |   0.05724 |
-#> |.....................|    0.8887 |    0.6986 |     1.596 |    0.9470 |
-#> |.....................|    0.6683 |     2.264 |...........|...........|
-#> |    X|     479.00064 |     91.38 |  0.002950 |    0.2852 |    0.1123 |
-#> |.....................|  0.008117 |    0.5930 |     1.103 |   0.05724 |
-#> |.....................|    0.8887 |    0.6986 |     1.596 |    0.9470 |
-#> |.....................|    0.6683 |     2.264 |...........|...........|
-#> |  142|     478.99385 |     1.004 |    -1.610 |   -0.9359 |   -0.9216 |
-#> |.....................|    -1.190 |    -1.054 |   -0.2077 |   -0.9152 |
-#> |.....................|   -0.6665 |    -1.096 |   -0.5161 |   -0.8765 |
-#> |.....................|    -1.100 | -0.005738 |...........|...........|
-#> |    U|     478.99385 |     91.39 |    -5.810 |   -0.9127 |    -2.184 |
-#> |.....................|    -4.802 |    0.3808 |     1.107 |   0.05729 |
-#> |.....................|    0.8848 |    0.7019 |     1.599 |    0.9512 |
-#> |.....................|    0.6681 |     2.260 |...........|...........|
-#> |    X|     478.99385 |     91.39 |  0.002997 |    0.2864 |    0.1126 |
-#> |.....................|  0.008212 |    0.5941 |     1.107 |   0.05729 |
-#> |.....................|    0.8848 |    0.7019 |     1.599 |    0.9512 |
-#> |.....................|    0.6681 |     2.260 |...........|...........|
-#> |    F| Forward Diff. |     2.499 |    0.2382 |  -0.03703 |  -0.03958 |
-#> |.....................|   0.09629 |   -0.2111 |    0.3210 |    0.2393 |
-#> |.....................|   -0.1233 |   -0.7892 |     1.126 |   -0.4047 |
-#> |.....................|    -1.051 |   -0.3984 |...........|...........|
-#> |  143|     478.98455 |     1.004 |    -1.625 |   -0.9347 |   -0.9200 |
-#> |.....................|    -1.200 |    -1.054 |   -0.2131 |   -0.9088 |
-#> |.....................|   -0.6653 |    -1.094 |   -0.5167 |   -0.8757 |
-#> |.....................|    -1.099 |  0.008183 |...........|...........|
-#> |    U|     478.98455 |     91.36 |    -5.825 |   -0.9116 |    -2.182 |
-#> |.....................|    -4.813 |    0.3812 |     1.105 |   0.05748 |
-#> |.....................|    0.8857 |    0.7042 |     1.598 |    0.9520 |
-#> |.....................|    0.6689 |     2.277 |...........|...........|
-#> |    X|     478.98455 |     91.36 |  0.002951 |    0.2867 |    0.1128 |
-#> |.....................|  0.008125 |    0.5942 |     1.105 |   0.05748 |
-#> |.....................|    0.8857 |    0.7042 |     1.598 |    0.9520 |
-#> |.....................|    0.6689 |     2.277 |...........|...........|
-#> |    F| Forward Diff. |   -0.2799 |    0.1926 |  -0.02074 |  -0.02333 |
-#> |.....................|   0.08052 |   -0.1468 |    0.2817 |    0.3348 |
-#> |.....................|   -0.1470 |   -0.6425 |     1.062 |   -0.3208 |
-#> |.....................|   -0.8181 |   -0.3186 |...........|...........|
-#> |  144|     478.97736 |     1.005 |    -1.639 |   -0.9325 |   -0.9174 |
-#> |.....................|    -1.210 |    -1.043 |   -0.2100 |   -0.9166 |
-#> |.....................|   -0.6557 |    -1.093 |   -0.5206 |   -0.8754 |
-#> |.....................|    -1.097 |   0.01446 |...........|...........|
-#> |    U|     478.97736 |     91.42 |    -5.839 |   -0.9097 |    -2.180 |
-#> |.....................|    -4.822 |    0.3861 |     1.106 |   0.05725 |
-#> |.....................|    0.8927 |    0.7053 |     1.594 |    0.9522 |
-#> |.....................|    0.6711 |     2.284 |...........|...........|
-#> |    X|     478.97736 |     91.42 |  0.002912 |    0.2871 |    0.1131 |
-#> |.....................|  0.008047 |    0.5953 |     1.106 |   0.05725 |
-#> |.....................|    0.8927 |    0.7053 |     1.594 |    0.9522 |
-#> |.....................|    0.6711 |     2.284 |...........|...........|
-#> |    F| Forward Diff. |     5.719 |    0.1644 |    0.1764 | 0.0002018 |
-#> |.....................|   0.06754 |    0.1935 |  -0.08189 |   -0.1310 |
-#> |.....................|  -0.08678 |    -2.826 |    0.8338 |   -0.2552 |
-#> |.....................|   -0.4561 |   -0.1956 |...........|...........|
-#> |  145|     478.97194 |     1.004 |    -1.652 |   -0.9304 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2044 |   -0.9254 |
-#> |.....................|   -0.6443 |    -1.087 |   -0.5238 |   -0.8740 |
-#> |.....................|    -1.092 |   0.01749 |...........|...........|
-#> |    U|     478.97194 |     91.40 |    -5.852 |   -0.9078 |    -2.178 |
-#> |.....................|    -4.833 |    0.3880 |     1.108 |   0.05699 |
-#> |.....................|    0.9010 |    0.7106 |     1.590 |    0.9536 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.97194 |     91.40 |  0.002874 |    0.2875 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05699 |
-#> |.....................|    0.9010 |    0.7106 |     1.590 |    0.9536 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    F| Forward Diff. |     2.925 |    0.1117 |    0.2312 |   0.02461 |
-#> |.....................|   0.04286 |    0.3818 |    0.1548 |   -0.1592 |
-#> |.....................|  -0.04325 |   -0.1382 |    0.7430 |   -0.2262 |
-#> |.....................|  -0.01070 |   -0.1316 |...........|...........|
-#> |  146|     479.08778 |    0.9990 |    -1.662 |   -0.9298 |   -0.9158 |
-#> |.....................|    -1.224 |    -1.050 |   -0.2095 |   -0.9175 |
-#> |.....................|   -0.6325 |    -1.087 |   -0.5258 |   -0.8715 |
-#> |.....................|    -1.094 |   0.02816 |...........|...........|
-#> |    U|     479.08778 |     90.91 |    -5.862 |   -0.9073 |    -2.178 |
-#> |.....................|    -4.836 |    0.3828 |     1.106 |   0.05722 |
-#> |.....................|    0.9096 |    0.7103 |     1.587 |    0.9559 |
-#> |.....................|    0.6733 |     2.301 |...........|...........|
-#> |    X|     479.08778 |     90.91 |  0.002845 |    0.2876 |    0.1132 |
-#> |.....................|  0.007936 |    0.5946 |     1.106 |   0.05722 |
-#> |.....................|    0.9096 |    0.7103 |     1.587 |    0.9559 |
-#> |.....................|    0.6733 |     2.301 |...........|...........|
-#> |  147|     478.99303 |     1.002 |    -1.652 |   -0.9306 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2045 |   -0.9253 |
-#> |.....................|   -0.6442 |    -1.087 |   -0.5244 |   -0.8738 |
-#> |.....................|    -1.092 |   0.01760 |...........|...........|
-#> |    U|     478.99303 |     91.18 |    -5.852 |   -0.9080 |    -2.178 |
-#> |.....................|    -4.833 |    0.3879 |     1.108 |   0.05700 |
-#> |.....................|    0.9011 |    0.7107 |     1.589 |    0.9537 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.99303 |     91.18 |  0.002874 |    0.2874 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05700 |
-#> |.....................|    0.9011 |    0.7107 |     1.589 |    0.9537 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |  148|     478.97158 |     1.004 |    -1.652 |   -0.9304 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2044 |   -0.9254 |
-#> |.....................|   -0.6443 |    -1.087 |   -0.5239 |   -0.8740 |
-#> |.....................|    -1.092 |   0.01751 |...........|...........|
-#> |    U|     478.97158 |     91.37 |    -5.852 |   -0.9078 |    -2.178 |
-#> |.....................|    -4.833 |    0.3880 |     1.108 |   0.05699 |
-#> |.....................|    0.9010 |    0.7106 |     1.590 |    0.9536 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.97158 |     91.37 |  0.002874 |    0.2874 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05699 |
-#> |.....................|    0.9010 |    0.7106 |     1.590 |    0.9536 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    F| Forward Diff. |   -0.1518 |    0.1094 |    0.1916 |   0.02921 |
-#> |.....................|   0.04385 |    0.3896 |   -0.2077 |   -0.4379 |
-#> |.....................|  -0.03471 |    -2.421 |    0.7262 |   -0.1589 |
-#> |.....................|   0.01110 |   -0.1305 |...........|...........|
-#> |  149|     478.97152 |     1.004 |    -1.652 |   -0.9304 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2044 |   -0.9254 |
-#> |.....................|   -0.6443 |    -1.086 |   -0.5240 |   -0.8739 |
-#> |.....................|    -1.092 |   0.01753 |...........|...........|
-#> |    U|     478.97152 |     91.37 |    -5.852 |   -0.9078 |    -2.178 |
-#> |.....................|    -4.833 |    0.3880 |     1.108 |   0.05699 |
-#> |.....................|    0.9010 |    0.7109 |     1.590 |    0.9536 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.97152 |     91.37 |  0.002874 |    0.2874 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05699 |
-#> |.....................|    0.9010 |    0.7109 |     1.590 |    0.9536 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    C| Central Diff. |   -0.2246 |    0.1050 |    0.1574 |   0.02036 |
-#> |.....................|   0.04103 |    0.3470 |   -0.3387 |   -0.1919 |
-#> |.....................|   -0.1172 |   -0.1870 |    0.6243 |   -0.2341 |
-#> |.....................|  -0.06769 |   -0.1265 |...........|...........|
-#> |  150|     478.97142 |     1.004 |    -1.652 |   -0.9305 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2042 |   -0.9253 |
-#> |.....................|   -0.6442 |    -1.086 |   -0.5242 |   -0.8739 |
-#> |.....................|    -1.092 |   0.01757 |...........|...........|
-#> |    U|     478.97142 |     91.38 |    -5.852 |   -0.9079 |    -2.178 |
-#> |.....................|    -4.833 |    0.3879 |     1.108 |   0.05700 |
-#> |.....................|    0.9011 |    0.7110 |     1.589 |    0.9537 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.97142 |     91.38 |  0.002874 |    0.2874 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05700 |
-#> |.....................|    0.9011 |    0.7110 |     1.589 |    0.9537 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    C| Central Diff. |    0.5593 |    0.1052 |    0.1640 |   0.01900 |
-#> |.....................|   0.04052 |    0.3419 |   -0.3227 |   -0.1646 |
-#> |.....................|   -0.1158 |   -0.1768 |    0.1839 |   -0.2151 |
-#> |.....................|  -0.04116 |   -0.1006 |...........|...........|
-#> |  151|     478.97143 |     1.004 |    -1.652 |   -0.9306 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2041 |   -0.9252 |
-#> |.....................|   -0.6442 |    -1.086 |   -0.5243 |   -0.8738 |
-#> |.....................|    -1.092 |   0.01761 |...........|...........|
-#> |    U|     478.97143 |     91.36 |    -5.852 |   -0.9079 |    -2.178 |
-#> |.....................|    -4.833 |    0.3879 |     1.108 |   0.05700 |
-#> |.....................|    0.9011 |    0.7110 |     1.589 |    0.9538 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.97143 |     91.36 |  0.002874 |    0.2874 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05700 |
-#> |.....................|    0.9011 |    0.7110 |     1.589 |    0.9538 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |  152|     478.97137 |     1.004 |    -1.652 |   -0.9305 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2042 |   -0.9253 |
-#> |.....................|   -0.6442 |    -1.086 |   -0.5242 |   -0.8738 |
-#> |.....................|    -1.092 |   0.01759 |...........|...........|
-#> |    U|     478.97137 |     91.37 |    -5.852 |   -0.9079 |    -2.178 |
-#> |.....................|    -4.833 |    0.3879 |     1.108 |   0.05700 |
-#> |.....................|    0.9011 |    0.7110 |     1.589 |    0.9537 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.97137 |     91.37 |  0.002874 |    0.2874 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05700 |
-#> |.....................|    0.9011 |    0.7110 |     1.589 |    0.9537 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    C| Central Diff. |   -0.4660 |    0.1043 |    0.1497 |   0.02048 |
-#> |.....................|   0.04080 |    0.3434 |   -0.3050 |   -0.1804 |
-#> |.....................|   -0.2015 |    -1.954 |    0.1460 |   -0.2263 |
-#> |.....................|  -0.03239 |   -0.1147 |...........|...........|
-#> |  153|     478.97135 |     1.004 |    -1.652 |   -0.9305 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2041 |   -0.9253 |
-#> |.....................|   -0.6441 |    -1.086 |   -0.5242 |   -0.8738 |
-#> |.....................|    -1.092 |   0.01760 |...........|...........|
-#> |    U|     478.97135 |     91.36 |    -5.852 |   -0.9079 |    -2.178 |
-#> |.....................|    -4.833 |    0.3879 |     1.108 |   0.05700 |
-#> |.....................|    0.9012 |    0.7110 |     1.589 |    0.9538 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.97135 |     91.36 |  0.002874 |    0.2874 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05700 |
-#> |.....................|    0.9012 |    0.7110 |     1.589 |    0.9538 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    C| Central Diff. |   -0.8144 |    0.1038 |    0.1446 |   0.02101 |
-#> |.....................|   0.04083 |    0.3431 |   -0.3133 |   -0.1844 |
-#> |.....................|  -0.05440 |    -1.096 |    0.1463 |   -0.2004 |
-#> |.....................|    0.2780 |   -0.1269 |...........|...........|
-#> |  154|     478.97125 |     1.004 |    -1.652 |   -0.9305 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2041 |   -0.9252 |
-#> |.....................|   -0.6441 |    -1.086 |   -0.5243 |   -0.8738 |
-#> |.....................|    -1.092 |   0.01762 |...........|...........|
-#> |    U|     478.97125 |     91.37 |    -5.852 |   -0.9079 |    -2.178 |
-#> |.....................|    -4.833 |    0.3879 |     1.108 |   0.05700 |
-#> |.....................|    0.9012 |    0.7111 |     1.589 |    0.9538 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.97125 |     91.37 |  0.002874 |    0.2874 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05700 |
-#> |.....................|    0.9012 |    0.7111 |     1.589 |    0.9538 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    C| Central Diff. |   0.03985 |    0.1039 |    0.1540 |   0.01970 |
-#> |.....................|   0.04056 |    0.3392 |   -0.3415 |   -0.1666 |
-#> |.....................|   -0.1386 |   -0.1574 |   0.08901 |   -0.2003 |
-#> |.....................|  -0.04000 |   -0.1187 |...........|...........|
-#> |  155|     478.97118 |     1.004 |    -1.652 |   -0.9306 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2040 |   -0.9252 |
-#> |.....................|   -0.6440 |    -1.086 |   -0.5243 |   -0.8737 |
-#> |.....................|    -1.092 |   0.01765 |...........|...........|
-#> |    U|     478.97118 |     91.37 |    -5.852 |   -0.9080 |    -2.178 |
-#> |.....................|    -4.833 |    0.3878 |     1.108 |   0.05700 |
-#> |.....................|    0.9012 |    0.7112 |     1.589 |    0.9538 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.97118 |     91.37 |  0.002874 |    0.2874 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05700 |
-#> |.....................|    0.9012 |    0.7112 |     1.589 |    0.9538 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    C| Central Diff. |  -0.05720 |    0.1036 |    0.1507 |   0.01972 |
-#> |.....................|   0.04048 |    0.3375 |   -0.2940 |   -0.1684 |
-#> |.....................|   -0.1979 |    -1.920 |    0.1339 |   -0.2027 |
-#> |.....................|  -0.04399 |   -0.1216 |...........|...........|
-#> |  156|     478.97118 |     1.004 |    -1.652 |   -0.9306 |   -0.9153 |
-#> |.....................|    -1.221 |    -1.039 |   -0.2040 |   -0.9252 |
-#> |.....................|   -0.6440 |    -1.086 |   -0.5243 |   -0.8737 |
-#> |.....................|    -1.092 |   0.01765 |...........|...........|
-#> |    U|     478.97118 |     91.37 |    -5.852 |   -0.9080 |    -2.178 |
-#> |.....................|    -4.833 |    0.3878 |     1.108 |   0.05700 |
-#> |.....................|    0.9012 |    0.7112 |     1.589 |    0.9538 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> |    X|     478.97118 |     91.37 |  0.002874 |    0.2874 |    0.1133 |
-#> |.....................|  0.007961 |    0.5958 |     1.108 |   0.05700 |
-#> |.....................|    0.9012 |    0.7112 |     1.589 |    0.9538 |
-#> |.....................|    0.6749 |     2.288 |...........|...........|
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-
-# Two-component error by variable is possible with both estimation methods
-# Variance by variable is supported by 'saem' and 'focei'
-f_nlmixr_fomc_sfo_saem_obs_tc <- nlmixr(f_mmkin_tc["FOMC-SFO", ], est = "saem",
-  error_model = "obs_tc")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#>  
-#> 1:    92.0624   -5.2854    0.1952    1.9494   -1.9431    2.8500    1.6150    0.7315    0.7220    0.4370    6.8425    0.4265    7.3797    0.5659
-#> 2:    92.7371   -5.3819    0.0345    2.0839   -2.0310    2.7075    1.5342    0.6949    0.8358    0.4151    7.2043    0.0003    8.1096    0.0003
-#> 3:    9.2941e+01  -5.7880e+00   1.0336e-01   2.5772e+00  -1.5152e+00   2.5721e+00   1.4575e+00   6.6018e-01   7.9403e-01   3.9439e-01   4.5749e+00   1.5986e-05   5.1354e+00   2.8796e-05
-#> 4:    92.6277   -5.8599    0.0858    2.5068   -1.3253    2.4435    1.3847    0.6272    0.7543    0.3747    3.4165    0.0001    3.9071    0.0016
-#> 5:    93.0289   -6.0258    0.0528    2.4932   -1.1961    2.3213    1.3154    0.5958    0.7166    0.3559    3.2552    0.0069    3.3744    0.0170
-#> 6:    93.2107   -6.2881    0.0143    2.4052   -1.1930    2.2053    2.2853    0.5660    0.6808    0.3381    2.8020    0.0086    3.1436    0.0256
-#> 7:    93.0563   -6.3624   -0.0104    2.3989   -1.1521    2.0950    2.4414    0.5377    0.6467    0.3212    2.6528    0.0209    2.8462    0.0289
-#> 8:    93.0567   -6.2699   -0.0303    2.3700   -1.0941    1.9903    2.5004    0.5204    0.6144    0.3052    2.3448    0.0314    2.5026    0.0349
-#> 9:    92.8366   -6.2013   -0.0507    2.3798   -1.0963    1.8907    2.6552    0.4943    0.5837    0.2899    2.2219    0.0368    2.2604    0.0448
-#> 10:    92.9069   -6.2499   -0.1116    2.3100   -1.0557    1.9625    3.9231    0.4696    0.5545    0.2754    2.0980    0.0359    2.1413    0.0325
-#> 11:    92.9942   -6.2134   -0.1037    2.3109   -1.0441    1.8643    3.7270    0.4755    0.5268    0.2616    1.9711    0.0372    1.9901    0.0355
-#> 12:    92.9262   -6.2511   -0.1133    2.2707   -1.0465    1.8430    4.3304    0.4697    0.5004    0.2486    1.8083    0.0346    1.9184    0.0356
-#> 13:    93.0761   -6.3559   -0.1106    2.2534   -1.0162    2.4826    5.2857    0.4685    0.4754    0.2361    1.7896    0.0331    1.9865    0.0342
-#> 14:    93.0929   -6.1852   -0.1058    2.2972   -1.0175    2.9964    5.0214    0.4451    0.4516    0.2243    1.8316    0.0309    1.9112    0.0348
-#> 15:    93.3343   -6.3408   -0.1025    2.2905   -0.9962    3.1132    4.9630    0.4594    0.4291    0.2131    1.8198    0.0338    1.9154    0.0372
-#> 16:    92.9959   -6.2227   -0.1016    2.2869   -1.0103    3.3338    4.7149    0.4598    0.4076    0.2025    1.8726    0.0327    1.9617    0.0361
-#> 17:    93.0394   -6.2586   -0.1027    2.2932   -0.9991    3.1671    4.8730    0.4591    0.3872    0.1923    1.8405    0.0336    2.0192    0.0242
-#> 18:    93.2374   -6.3410   -0.1110    2.2965   -0.9689    3.0087    5.4325    0.4632    0.3679    0.1827    1.9051    0.0351    1.9247    0.0277
-#> 19:    93.0557   -6.4503   -0.1011    2.2941   -0.9884    2.8583    6.2872    0.4742    0.3495    0.1736    1.8054    0.0345    1.9173    0.0260
-#> 20:    92.9280   -6.4945   -0.1018    2.2902   -0.9864    3.5934    6.8737    0.4751    0.3320    0.1649    1.7097    0.0372    1.9483    0.0225
-#> 21:    93.2023   -6.3418   -0.1033    2.2846   -0.9863    3.4138    6.5300    0.4710    0.3154    0.1567    1.7507    0.0318    1.9030    0.0249
-#> 22:    93.5494   -6.1985   -0.1078    2.2991   -1.0171    3.2431    6.2035    0.4475    0.2996    0.1488    1.7370    0.0342    1.8124    0.0282
-#> 23:    93.3588   -6.2577   -0.1084    2.2654   -0.9956    3.0809    5.8933    0.4393    0.2869    0.1481    1.6928    0.0380    1.8288    0.0254
-#> 24:    93.5705   -6.4876   -0.1083    2.2606   -1.0062    3.7095    6.7801    0.4459    0.2726    0.1684    1.7001    0.0377    1.9012    0.0249
-#> 25:    93.9726   -6.5638   -0.1239    2.2374   -1.0071    5.1357    6.6571    0.4608    0.2755    0.1600    1.6615    0.0382    1.8846    0.0213
-#> 26:    93.8894   -6.5073   -0.1120    2.2645   -1.0327    4.8789    6.3243    0.4473    0.3014    0.1520    1.7152    0.0340    1.8990    0.0254
-#> 27:    94.5348   -6.3868   -0.0891    2.3139   -1.0361    5.3856    6.0081    0.4250    0.3080    0.1453    1.7028    0.0385    1.7853    0.0304
-#> 28:    93.9221   -6.1747   -0.1039    2.3013   -1.0087    5.1163    5.7077    0.4214    0.3136    0.1634    1.6823    0.0340    1.7487    0.0353
-#> 29:    93.4946   -6.0264   -0.0940    2.3124   -1.0166    5.3744    5.4223    0.4404    0.3114    0.1813    1.6310    0.0370    1.7646    0.0367
-#> 30:    93.9287   -5.9114   -0.0967    2.3078   -1.0090    5.2017    5.1512    0.4381    0.3048    0.2091    1.5825    0.0393    1.7431    0.0312
-#> 31:    93.7065   -6.0174   -0.0928    2.2917   -0.9880    5.1935    4.8936    0.4352    0.3109    0.1986    1.5876    0.0392    1.8465    0.0280
-#> 32:    93.7675   -5.6444   -0.0918    2.3145   -0.9664    4.9338    4.6489    0.4332    0.3090    0.1918    1.6874    0.0332    1.7501    0.0331
-#> 33:    94.2589   -5.7637   -0.0865    2.3130   -0.9733    4.6871    4.4165    0.4235    0.2935    0.1865    1.7173    0.0355    1.7365    0.0334
-#> 34:    94.0788   -5.7432   -0.1022    2.3049   -0.9681    4.4528    4.1957    0.4319    0.2962    0.1772    1.6357    0.0361    1.4755    0.0574
-#> 35:    94.0798   -5.8549   -0.0929    2.2856   -0.9849    4.2301    3.9859    0.4391    0.2937    0.1734    1.6460    0.0275    1.7739    0.0379
-#> 36:    93.9997   -5.8708   -0.0890    2.2870   -1.0134    4.0186    3.7866    0.4268    0.2819    0.1840    1.5830    0.0258    1.8922    0.0320
-#> 37:    93.8186   -5.8979   -0.0973    2.2807   -1.0197    3.8177    3.5973    0.4280    0.2778    0.1799    1.5783    0.0282    1.7697    0.0404
-#> 38:    94.0728   -5.9601   -0.0936    2.3011   -1.0381    3.6268    3.4174    0.4186    0.2944    0.1864    1.5780    0.0294    1.5210    0.0558
-#> 39:    94.0504   -5.8302   -0.0995    2.2847   -1.0418    3.4455    3.2465    0.4240    0.2796    0.1771    1.6888    0.0242    1.7744    0.0366
-#> 40:    93.8918   -5.9418   -0.0988    2.2925   -1.0613    3.2732    3.0842    0.4144    0.2672    0.1837    1.7275    0.0232    1.7840    0.0357
-#> 41:    93.7961   -6.0741   -0.0896    2.2932   -1.0359    3.1095    3.2890    0.4236    0.2606    0.1782    1.7591    0.0212    1.8920    0.0273
-#> 42:    93.9458   -6.0319   -0.0909    2.3114   -1.0281    3.0544    3.1246    0.4196    0.2598    0.1839    1.6854    0.0310    1.7586    0.0308
-#> 43:    93.7623   -6.0165   -0.1056    2.2837   -1.0378    3.9092    3.2100    0.4298    0.2468    0.1747    1.7064    0.0286    1.6676    0.0397
-#> 44:    93.4300   -5.9019   -0.1114    2.2716   -1.0167    4.4100    3.0495    0.4476    0.2345    0.1687    1.7989    0.0253    1.7741    0.0299
-#> 45:    93.3475   -5.9962   -0.1231    2.2546   -1.0007    6.4879    3.3965    0.4528    0.2452    0.1602    1.7283    0.0276    1.7219    0.0379
-#> 46:    93.3100   -6.0073   -0.1255    2.2483   -0.9962    6.6009    3.5942    0.4520    0.2533    0.1568    1.6991    0.0258    1.1783    0.0706
-#> 47:    93.4422   -5.8442   -0.1286    2.2578   -0.9819    6.2709    3.4145    0.4492    0.2637    0.1694    1.6754    0.0317    1.3442    0.0599
-#> 48:    93.0996   -5.5881   -0.1307    2.2541   -0.9882    5.9573    3.2438    0.4480    0.2665    0.1695    1.7040    0.0285    1.6825    0.0426
-#> 49:    93.3649   -5.8011   -0.1260    2.2595   -0.9704    5.7230    3.0816    0.4399    0.2646    0.1715    1.6544    0.0297    1.6414    0.0418
-#> 50:    93.9331   -5.8731   -0.1195    2.2615   -0.9837    5.4368    2.9275    0.4453    0.2735    0.1940    1.6316    0.0289    1.6885    0.0392
-#> 51:    93.6092   -5.8721   -0.1237    2.2599   -1.0015    5.1650    2.7811    0.4413    0.2865    0.1939    1.6492    0.0272    1.7686    0.0358
-#> 52:    93.3008   -5.9775   -0.1277    2.2628   -0.9962    4.9067    3.1139    0.4438    0.2946    0.1963    1.5642    0.0337    1.7391    0.0335
-#> 53:    93.6347   -6.0805   -0.1189    2.2663   -1.0177    4.6614    3.5169    0.4335    0.2962    0.2043    1.5275    0.0343    1.7417    0.0366
-#> 54:    93.5781   -6.0412   -0.1166    2.2573   -1.0015    4.4283    3.3411    0.4395    0.2912    0.2080    1.5464    0.0346    1.7584    0.0359
-#> 55:    93.9675   -6.0867   -0.0952    2.2970   -0.9987    4.2069    3.6762    0.4550    0.2780    0.1988    1.5138    0.0405    1.6251    0.0472
-#> 56:    94.4069   -6.1375   -0.0943    2.2975   -1.0190    3.9966    4.2280    0.4550    0.2806    0.1945    1.5294    0.0425    1.6443    0.0468
-#> 57:    93.8076   -6.1618   -0.0936    2.2687   -1.0237    3.7967    4.3085    0.4524    0.2666    0.1897    1.5227    0.0414    1.6955    0.0438
-#> 58:    93.9188   -6.2272   -0.0947    2.2767   -1.0408    3.6069    4.6707    0.4536    0.2676    0.1873    1.5201    0.0425    1.5336    0.0550
-#> 59:    93.9572   -6.3460   -0.1074    2.2746   -1.0069    3.4266    5.8058    0.4614    0.2718    0.1919    1.5533    0.0417    1.6227    0.0460
-#> 60:    93.5430   -6.1622   -0.1048    2.2861   -0.9959    3.2552    5.5155    0.4535    0.2848    0.1823    1.4745    0.0431    1.5242    0.0522
-#> 61:    93.8016   -6.4079   -0.1065    2.2897   -1.0325    3.0925    5.9252    0.4583    0.2901    0.1732    1.5364    0.0365    1.4623    0.0550
-#> 62:    93.4249   -6.2284   -0.0967    2.3126   -1.0208    2.9378    5.6289    0.4429    0.2756    0.1645    1.6111    0.0325    1.3996    0.0618
-#> 63:    93.2335   -6.0996   -0.1051    2.3047   -0.9976    2.7909    5.3475    0.4292    0.2719    0.1633    1.6010    0.0326    1.5115    0.0494
-#> 64:    92.7091   -6.1109   -0.1041    2.3032   -0.9746    3.2610    5.0801    0.4301    0.2793    0.1751    1.5979    0.0302    1.3867    0.0575
-#> 65:    92.6059   -6.0049   -0.1077    2.3062   -0.9853    3.0979    4.8261    0.4316    0.2826    0.1714    1.6357    0.0272    1.3931    0.0543
-#> 66:    92.7778   -6.0856   -0.1040    2.3057   -0.9828    2.9430    4.5848    0.4362    0.2888    0.1628    1.6126    0.0316    1.4340    0.0505
-#> 67:    93.0325   -6.1775   -0.1085    2.3122   -0.9714    2.7959    4.3790    0.4464    0.2843    0.1547    1.6090    0.0354    1.4966    0.0448
-#> 68:    92.8987   -5.8741   -0.1089    2.3184   -0.9567    2.6561    4.1601    0.4389    0.2866    0.1470    1.5888    0.0347    1.4492    0.0507
-#> 69:    92.7300   -6.0473   -0.1070    2.3082   -0.9739    2.5233    4.0183    0.4371    0.3158    0.1527    1.5904    0.0298    1.5387    0.0477
-#> 70:    92.5285   -6.0962   -0.1115    2.3179   -0.9785    2.4856    4.0612    0.4380    0.3059    0.1504    1.5237    0.0402    1.4541    0.0463
-#> 71:    92.3975   -6.2090   -0.1269    2.2819   -0.9713    2.3613    4.3811    0.4173    0.2906    0.1520    1.5388    0.0316    1.3713    0.0584
-#> 72:    92.1593   -6.2214   -0.1217    2.2950   -0.9481    2.2433    5.1205    0.4227    0.2760    0.1605    1.5431    0.0312    1.5797    0.0459
-#> 73:    92.1195   -6.6667   -0.1244    2.3076   -0.9642    2.1311    7.6538    0.4124    0.2622    0.1525    1.4505    0.0375    1.2810    0.0595
-#> 74:    92.2191   -6.6665   -0.1278    2.2989   -0.9703    2.0246    7.2711    0.4098    0.2491    0.1666    1.4309    0.0384    1.2717    0.0638
-#> 75:    92.4656   -6.8881   -0.1274    2.3011   -0.9595    1.9233    8.3835    0.4147    0.2367    0.1656    1.4181    0.0424    1.2498    0.0620
-#> 76:    92.4593   -6.2323   -0.1203    2.2912   -0.9799    1.8272    7.9643    0.3967    0.2301    0.1596    1.5448    0.0336    1.6758    0.0359
-#> 77:    92.4501   -6.1123   -0.1219    2.2889   -0.9426    1.7358    7.5661    0.4049    0.2299    0.1594    1.5380    0.0327    1.6947    0.0364
-#> 78:    92.5059   -6.0339   -0.1198    2.2985   -0.9544    1.6490    7.1878    0.4007    0.2422    0.1568    1.5722    0.0302    1.5665    0.0415
-#> 79:    92.4302   -6.6428   -0.1141    2.3119   -0.9421    1.5666    9.0889    0.3986    0.2340    0.1489    1.5029    0.0306    1.1894    0.0638
-#> 80:    92.5305   -6.3036   -0.1127    2.3099   -0.9406    1.9062    8.6344    0.4091    0.2327    0.1648    1.5558    0.0308    1.0136    0.0749
-#> 81:    92.6652   -6.0832   -0.1167    2.2994   -0.9552    2.3641    8.2027    0.4142    0.2348    0.1566    1.6232    0.0300    1.1320    0.0712
-#> 82:    92.5109   -6.1524   -0.1100    2.3037   -0.9686    2.2459    7.7926    0.4145    0.2381    0.1695    1.6128    0.0306    1.6145    0.0413
-#> 83:    92.6455   -6.3979   -0.1059    2.3245   -0.9573    2.1336    8.1077    0.4060    0.2348    0.1667    1.6039    0.0304    1.6251    0.0419
-#> 84:    92.5768   -6.3469   -0.0979    2.3177   -0.9346    2.0269    8.2125    0.4141    0.2439    0.1720    1.6334    0.0302    1.5803    0.0450
-#> 85:    92.7920   -6.3536   -0.0969    2.3363   -0.9389    1.9256    8.1820    0.4035    0.2512    0.1713    1.5815    0.0338    1.1193    0.0719
-#> 86:    92.8571   -6.2567   -0.0911    2.3426   -0.9633    1.8293    8.1211    0.4008    0.2659    0.1627    1.5840    0.0356    1.2425    0.0639
-#> 87:    92.9101   -6.1557   -0.0937    2.3326   -0.9624    1.7378    7.7151    0.3950    0.2839    0.1546    1.6017    0.0354    1.0600    0.0766
-#> 88:    92.7649   -6.2151   -0.0881    2.3275   -0.9967    1.6509    7.3293    0.4046    0.2697    0.1469    1.6092    0.0302    1.1839    0.0693
-#> 89:    92.9350   -5.9222   -0.0903    2.3372   -0.9612    1.5684    6.9628    0.4058    0.2818    0.1395    1.5957    0.0335    1.5450    0.0444
-#> 90:    92.7895   -5.9348   -0.0890    2.3457   -0.9601    1.4900    6.6147    0.4070    0.2705    0.1430    1.5716    0.0378    1.4918    0.0439
-#> 91:    93.0113   -5.9302   -0.0997    2.3316   -0.9489    1.4155    6.2840    0.4424    0.2929    0.1410    1.5582    0.0377    1.2459    0.0582
-#> 92:    92.8603   -6.3366   -0.0918    2.3356   -0.9938    1.3447    5.9698    0.4287    0.2929    0.1531    1.4906    0.0398    1.2421    0.0605
-#> 93:    92.8094   -6.1097   -0.0953    2.3382   -0.9996    1.2775    5.6713    0.4309    0.2783    0.1597    1.4317    0.0468    1.2694    0.0584
-#> 94:    92.7100   -6.1043   -0.0909    2.3287   -0.9928    1.3828    5.3877    0.4337    0.2698    0.1517    1.4173    0.0489    1.4335    0.0476
-#> 95:    92.2055   -6.1792   -0.0889    2.3553   -0.9983    1.3137    5.1183    0.4209    0.3273    0.1566    1.4865    0.0417    1.2485    0.0681
-#> 96:    92.3225   -6.2710   -0.0811    2.3734   -1.0043    1.3428    4.8624    0.4121    0.3110    0.1532    1.5817    0.0374    1.5209    0.0532
-#> 97:    92.2983   -6.3023   -0.0776    2.3615   -0.9801    1.2757    4.6193    0.4221    0.3018    0.1455    1.5971    0.0337    1.2137    0.0719
-#> 98:    92.1433   -6.3114   -0.0935    2.3269   -0.9866    1.2227    4.8121    0.4327    0.2907    0.1694    1.5524    0.0303    1.1779    0.0727
-#> 99:    92.1631   -6.3090   -0.0908    2.3197   -0.9891    1.1615    4.9271    0.4169    0.2859    0.1736    1.5303    0.0334    1.6227    0.0511
-#> 100:    92.1185   -6.3603   -0.0950    2.3280   -1.0209    1.1035    5.0957    0.4213    0.2924    0.1817    1.5991    0.0330    1.7197    0.0445
-#> 101:    92.3964   -6.0447   -0.0898    2.3347   -1.0164    1.0483    4.8409    0.4251    0.2778    0.1727    1.5708    0.0422    1.6197    0.0461
-#> 102:    92.6597   -6.2545   -0.0954    2.3264   -1.0206    0.9959    4.5989    0.4218    0.2736    0.1640    1.5853    0.0408    1.5912    0.0455
-#> 103:    92.7866   -6.3292   -0.0933    2.3148   -1.0013    0.9461    4.8935    0.4234    0.2599    0.1688    1.6299    0.0399    1.5921    0.0445
-#> 104:    92.8098   -6.2608   -0.1009    2.3014   -0.9947    0.8988    4.7750    0.4306    0.2548    0.1813    1.6363    0.0378    1.6713    0.0427
-#> 105:    92.8300   -5.9827   -0.1028    2.3155   -0.9896    0.8538    4.5362    0.4339    0.2664    0.1722    1.6079    0.0397    1.3691    0.0573
-#> 106:    92.8218   -6.1138   -0.1024    2.3462   -0.9750    0.8299    4.3094    0.4494    0.2530    0.1636    1.5761    0.0389    1.2857    0.0595
-#> 107:    92.9304   -6.0063   -0.1002    2.3269   -0.9778    0.7884    4.0939    0.4600    0.2404    0.1620    1.6499    0.0373    1.2101    0.0675
-#> 108:    92.9072   -6.0928   -0.0991    2.3183   -0.9732    0.7489    4.4394    0.4584    0.2518    0.1539    1.6509    0.0332    1.2346    0.0670
-#> 109:    92.7504   -6.1545   -0.0862    2.3423   -0.9618    0.7115    4.7501    0.4371    0.2766    0.1465    1.5755    0.0349    1.1552    0.0701
-#> 110:    92.9277   -6.3786   -0.0904    2.3468   -0.9402    0.6759    5.8620    0.4328    0.2821    0.1703    1.4661    0.0439    1.3292    0.0609
-#> 111:    92.8023   -5.8686   -0.0886    2.3653   -0.9417    0.7635    5.5689    0.4288    0.2680    0.1618    1.4278    0.0502    1.4715    0.0468
-#> 112:    92.9411   -5.8095   -0.0883    2.3625   -0.9322    0.8592    5.2905    0.4562    0.2586    0.1537    1.3920    0.0513    1.1766    0.0648
-#> 113:    92.9845   -6.0499   -0.0761    2.3626   -0.9533    0.8163    5.0259    0.4403    0.2595    0.1532    1.4306    0.0450    1.1416    0.0645
-#> 114:    92.7735   -6.0605   -0.0694    2.3497   -0.9646    0.7754    4.7746    0.4394    0.2682    0.1576    1.4866    0.0344    1.1127    0.0745
-#> 115:    92.7048   -6.1327   -0.0702    2.3427   -0.9910    0.7367    4.5359    0.4257    0.2736    0.1497    1.5045    0.0413    1.2783    0.0677
-#> 116:    92.7131   -6.0115   -0.0751    2.3370   -0.9899    0.6998    4.3091    0.4187    0.2638    0.1422    1.6036    0.0325    1.1109    0.0748
-#> 117:    92.7720   -5.9163   -0.0709    2.3503   -0.9566    0.6648    4.0937    0.4185    0.2555    0.1417    1.6016    0.0297    1.0778    0.0774
-#> 118:    92.9182   -5.9312   -0.0812    2.3436   -0.9731    0.6316    3.8890    0.4084    0.2667    0.1400    1.5698    0.0320    1.2364    0.0665
-#> 119:    92.9546   -5.9622   -0.0870    2.3330   -0.9934    0.6000    3.6945    0.4035    0.2867    0.1486    1.5364    0.0343    1.5892    0.0489
-#> 120:    92.9168   -6.0966   -0.0905    2.3301   -1.0045    0.5700    3.6677    0.3988    0.2871    0.1567    1.5378    0.0349    1.0886    0.0796
-#> 121:    92.7767   -6.1038   -0.0802    2.3396   -0.9815    0.5981    4.3032    0.3803    0.2884    0.1684    1.4788    0.0335    1.0886    0.0796
-#> 122:    92.8439   -6.2425   -0.0799    2.3323   -0.9987    0.6537    4.5745    0.3884    0.2834    0.1600    1.4786    0.0346    1.2146    0.0682
-#> 123:    92.8219   -5.7869   -0.0872    2.3478   -0.9619    0.7886    4.3458    0.3951    0.2887    0.1658    1.4827    0.0341    1.3911    0.0559
-#> 124:    92.7930   -5.7551   -0.0819    2.3559   -0.9809    0.8922    4.1285    0.3907    0.2972    0.1575    1.5329    0.0330    1.3824    0.0594
-#> 125:    92.7488   -5.9406   -0.0819    2.3550   -0.9797    0.8476    3.9221    0.3907    0.2996    0.1733    1.5096    0.0333    1.3148    0.0667
-#> 126:    92.7926   -5.7106   -0.0824    2.3560   -0.9653    0.8052    3.7260    0.3918    0.3018    0.1854    1.4237    0.0381    1.2607    0.0639
-#> 127:    92.9153   -5.6682   -0.0717    2.3654   -0.9645    0.7649    3.5397    0.3722    0.2948    0.1784    1.4679    0.0415    1.2310    0.0695
-#> 128:    92.8827   -5.7984   -0.0783    2.3813   -1.0047    1.1012    3.3627    0.3802    0.2997    0.1694    1.5187    0.0442    1.2884    0.0649
-#> 129:    92.8727   -5.7191   -0.0785    2.3426   -0.9857    1.0461    3.1946    0.3784    0.2984    0.1610    1.4757    0.0398    1.1695    0.0775
-#> 130:    92.8689   -5.8036   -0.0935    2.3123   -0.9783    0.9938    3.0348    0.4184    0.2980    0.1723    1.5143    0.0319    1.2298    0.0738
-#> 131:    92.8733   -5.6707   -0.0988    2.3045   -0.9936    1.3313    2.8831    0.4277    0.2831    0.1816    1.5919    0.0329    1.5260    0.0533
-#> 132:    92.5761   -5.7773   -0.0925    2.3211   -0.9661    1.2647    2.7389    0.4216    0.2815    0.1995    1.5306    0.0321    1.5863    0.0520
-#> 133:    92.4512   -5.7800   -0.0920    2.3269   -0.9625    1.2015    2.6020    0.4242    0.2674    0.1955    1.5669    0.0288    1.4087    0.0606
-#> 134:    92.5625   -5.7968   -0.0965    2.3271   -0.9728    1.1414    2.4719    0.4201    0.2753    0.1945    1.5935    0.0311    1.5348    0.0534
-#> 135:    92.3448   -5.6624   -0.0961    2.3303   -0.9600    1.0843    2.3483    0.4193    0.2728    0.1983    1.6245    0.0305    1.6281    0.0506
-#> 136:    92.3407   -5.7523   -0.0932    2.3208   -0.9897    1.0301    2.3267    0.4107    0.2668    0.1884    1.5933    0.0358    1.2970    0.0657
-#> 137:    92.3940   -6.0148   -0.1046    2.2981   -0.9866    0.9786    3.1382    0.4166    0.3012    0.1790    1.5077    0.0385    1.1944    0.0723
-#> 138:    92.3556   -5.9912   -0.1039    2.2969   -0.9920    0.9297    3.2144    0.4208    0.3039    0.1703    1.5042    0.0378    1.2588    0.0717
-#> 139:    92.5548   -5.9253   -0.1177    2.2723   -1.0079    0.8832    3.2648    0.4049    0.3263    0.1618    1.5558    0.0382    1.2673    0.0698
-#> 140:    92.6546   -6.0596   -0.1368    2.2659   -0.9922    0.8390    3.3893    0.3846    0.3100    0.1537    1.5475    0.0355    1.3190    0.0629
-#> 141:    92.6661   -5.9744   -0.1379    2.2793   -0.9754    0.8287    3.2725    0.3800    0.3178    0.1528    1.5076    0.0361    1.4087    0.0540
-#> 142:    92.5681   -5.7650   -0.1033    2.3249   -0.9613    0.7872    3.1089    0.3610    0.3564    0.1701    1.4733    0.0332    1.2603    0.0720
-#> 143:    92.4184   -5.6070   -0.1033    2.3520   -0.9764    0.7479    2.9534    0.3591    0.3758    0.1674    1.5420    0.0390    1.3280    0.0614
-#> 144:    92.5354   -5.6144   -0.0978    2.3801   -0.9425    0.7105    2.8058    0.3538    0.3606    0.1722    1.4884    0.0400    1.3455    0.0620
-#> 145:    92.4207   -5.6541   -0.0746    2.3873   -0.9633    0.6750    2.6655    0.3361    0.3426    0.1718    1.4981    0.0416    1.2440    0.0685
-#> 146:    92.3058   -5.6608   -0.0731    2.3755   -0.9732    0.6412    2.5322    0.3193    0.3304    0.1719    1.6391    0.0348    1.1788    0.0743
-#> 147:    92.4067   -5.7615   -0.0746    2.3775   -0.9903    0.6091    2.4056    0.3148    0.3311    0.1709    1.6695    0.0314    1.2931    0.0676
-#> 148:    92.3739   -5.8812   -0.0820    2.3644   -0.9823    0.5787    2.7260    0.3332    0.3296    0.1794    1.6168    0.0303    1.3206    0.0670
-#> 149:    92.4456   -5.8277   -0.0921    2.3508   -0.9924    0.5498    2.8750    0.3368    0.3305    0.1917    1.5602    0.0302    1.3622    0.0608
-#> 150:    92.5049   -5.7964   -0.1003    2.3353   -0.9809    0.5223    2.7312    0.3291    0.3634    0.1874    1.5035    0.0301    1.4002    0.0615
-#> 151:    92.3292   -6.0377   -0.1039    2.3301   -0.9866    0.4962    3.3342    0.3348    0.3626    0.1780    1.4819    0.0298    1.3217    0.0672
-#> 152:    92.3747   -6.0460   -0.1023    2.3154   -1.0242    0.5079    3.4530    0.3371    0.3518    0.1674    1.6034    0.0296    1.2304    0.0749
-#> 153:    92.3909   -5.8707   -0.1008    2.3284   -0.9897    0.5623    2.8180    0.3480    0.3792    0.1749    1.4953    0.0291    1.3442    0.0677
-#> 154:    92.2532   -5.9313   -0.0991    2.3232   -0.9839    0.5340    3.3946    0.3502    0.3723    0.1729    1.4837    0.0280    1.1452    0.0776
-#> 155:    92.1782   -6.1012   -0.0988    2.3339   -0.9600    0.3900    3.9676    0.3593    0.3704    0.1531    1.4927    0.0286    1.1848    0.0730
-#> 156:    92.2225   -5.8387   -0.0991    2.3393   -0.9459    0.3294    3.0685    0.3598    0.3808    0.1568    1.5540    0.0318    1.3419    0.0671
-#> 157:    92.2411   -5.7045   -0.1038    2.3578   -0.9252    0.2797    2.5238    0.3716    0.3579    0.1653    1.4704    0.0373    1.1959    0.0686
-#> 158:    92.2865   -5.6692   -0.1009    2.3771   -0.9532    0.2840    2.4144    0.3592    0.3610    0.1641    1.5065    0.0389    1.1780    0.0674
-#> 159:    92.2771   -5.7526   -0.0782    2.3632   -0.9771    0.2996    2.7295    0.3357    0.3779    0.1606    1.5818    0.0366    1.1512    0.0781
-#> 160:    92.3400   -5.8039   -0.0811    2.3615   -0.9453    0.2707    2.7305    0.3373    0.3834    0.1528    1.4765    0.0370    1.1427    0.0756
-#> 161:    92.4180   -5.7448   -0.0961    2.3653   -0.9508    0.2965    2.6051    0.3666    0.3833    0.1647    1.4581    0.0364    0.9817    0.0827
-#> 162:    92.4487   -5.8952   -0.0889    2.3460   -0.9646    0.2370    3.1413    0.3460    0.3801    0.1571    1.4528    0.0346    1.0006    0.0798
-#> 163:    92.5251   -5.8567   -0.0987    2.3342   -0.9615    0.1453    2.9917    0.3535    0.3735    0.1452    1.4521    0.0330    1.0498    0.0766
-#> 164:    92.5949   -6.1580   -0.1008    2.3332   -0.9749    0.1095    4.1797    0.3586    0.3767    0.1355    1.4659    0.0310    1.0218    0.0797
-#> 165:    92.5794   -6.0542   -0.1001    2.3321   -0.9795    0.1332    4.2924    0.3588    0.3752    0.1386    1.4858    0.0313    0.9836    0.0812
-#> 166:    92.6686   -6.0065   -0.0960    2.3623   -0.9532    0.1465    4.0810    0.3439    0.3683    0.1647    1.3929    0.0372    0.9354    0.0837
-#> 167:    92.7086   -6.2096   -0.0895    2.3656   -0.9552    0.1938    4.6857    0.3325    0.3519    0.1681    1.4281    0.0362    1.0329    0.0784
-#> 168:    92.6096   -6.0709   -0.0880    2.3595   -0.9474    0.2141    4.1277    0.3379    0.3527    0.1620    1.4264    0.0347    0.9627    0.0836
-#> 169:    92.5365   -5.9418   -0.0919    2.3546   -0.9575    0.3620    3.7767    0.3489    0.3589    0.1609    1.4761    0.0360    1.1348    0.0745
-#> 170:    92.6270   -5.8404   -0.0935    2.3562   -0.9517    0.3312    3.2506    0.3552    0.3607    0.1560    1.4506    0.0383    1.0731    0.0722
-#> 171:    92.5606   -5.9213   -0.0899    2.3513   -0.9554    0.4399    3.5587    0.3599    0.3646    0.1385    1.4779    0.0349    0.9844    0.0775
-#> 172:    92.3630   -5.7066   -0.0765    2.3798   -0.9314    0.5208    2.5578    0.3458    0.3657    0.1547    1.4900    0.0348    1.0485    0.0765
-#> 173:    92.2527   -5.5811   -0.0713    2.4173   -0.9221    0.8674    2.2100    0.3448    0.3370    0.1513    1.5403    0.0445    1.4403    0.0518
-#> 174:    92.3852   -5.5348   -0.0712    2.4066   -0.9033    0.7543    2.1568    0.3457    0.3324    0.1482    1.5322    0.0407    1.2744    0.0623
-#> 175:    92.4798   -5.5494   -0.0712    2.4004   -0.9100    0.5675    2.0147    0.3457    0.3333    0.1629    1.5229    0.0383    1.2917    0.0655
-#> 176:    92.5881   -5.5613   -0.0675    2.4180   -0.9188    0.4011    2.0736    0.3413    0.3487    0.1781    1.5149    0.0389    1.1499    0.0669
-#> 177:    92.6015   -5.4951   -0.0494    2.4324   -0.9525    0.4992    1.9009    0.3629    0.3353    0.1919    1.4881    0.0393    1.2289    0.0650
-#> 178:    92.6317   -5.4943   -0.0505    2.4373   -0.9298    0.5087    1.6116    0.3631    0.3324    0.1906    1.4475    0.0454    1.0764    0.0701
-#> 179:    92.7043   -5.5326   -0.0419    2.4386   -0.9376    0.4350    1.8241    0.3577    0.3757    0.1991    1.4445    0.0424    0.9626    0.0833
-#> 180:    92.7457   -5.5591   -0.0371    2.4684   -0.9450    0.3973    1.7797    0.3507    0.3707    0.1944    1.4392    0.0415    1.0784    0.0764
-#> 181:    92.6287   -5.5741   -0.0368    2.4489   -0.9459    0.4744    1.8016    0.3502    0.3544    0.1970    1.4317    0.0392    0.9225    0.0848
-#> 182:    92.6121   -5.5593   -0.0316    2.4610   -0.9345    0.6054    1.9206    0.3492    0.3538    0.1855    1.4410    0.0367    0.8977    0.0878
-#> 183:    92.4258   -5.4737   -0.0393    2.4592   -0.9319    0.8062    1.7845    0.3528    0.3544    0.1649    1.4545    0.0409    1.0723    0.0751
-#> 184:    92.3939   -5.5961   -0.0479    2.4268   -0.9435    1.0246    2.2534    0.3497    0.3289    0.1363    1.5022    0.0370    1.1058    0.0729
-#> 185:    92.4673   -5.5415   -0.0525    2.4157   -0.9058    0.8296    2.2848    0.3406    0.3314    0.1706    1.4935    0.0367    1.1362    0.0722
-#> 186:    92.4122   -5.6594   -0.0574    2.4466   -0.9430    0.9133    2.3350    0.3327    0.3596    0.1506    1.4450    0.0404    1.2273    0.0629
-#> 187:    92.5416   -5.5472   -0.0521    2.4393   -0.9261    0.9731    1.9228    0.3208    0.3673    0.1421    1.4890    0.0409    1.2553    0.0626
-#> 188:    92.5502   -5.6425   -0.0591    2.4345   -0.9246    0.9315    2.2041    0.3184    0.3639    0.1319    1.4896    0.0392    1.0986    0.0684
-#> 189:    92.4180   -5.6737   -0.0504    2.4448   -0.9191    0.9006    2.4647    0.3102    0.3743    0.1648    1.4649    0.0397    1.1320    0.0742
-#> 190:    92.5821   -5.5823   -0.0363    2.4588   -0.9205    0.9862    2.2692    0.2820    0.4087    0.1459    1.3938    0.0412    0.9562    0.0815
-#> 191:    92.3708   -5.5825   -0.0418    2.4621   -0.9231    0.9867    2.4743    0.2890    0.4196    0.1445    1.4619    0.0403    0.9630    0.0811
-#> 192:    92.2628   -5.5337   -0.0366    2.4392   -0.9194    0.6944    2.2771    0.2909    0.4169    0.1279    1.4745    0.0363    0.8601    0.0892
-#> 193:    92.4854   -5.6303   -0.0352    2.4484   -0.9316    0.4403    2.3253    0.2928    0.4109    0.1282    1.4768    0.0399    0.8886    0.0871
-#> 194:    92.4900   -5.5824   -0.0372    2.4648   -0.9451    0.4891    2.6428    0.2899    0.4160    0.1331    1.5124    0.0412    0.9340    0.0853
-#> 195:    92.4685   -5.7658   -0.0357    2.4659   -0.9217    0.4549    3.3767    0.2921    0.4171    0.1552    1.5062    0.0396    1.0336    0.0817
-#> 196:    92.4125   -5.7544   -0.0255    2.4834   -0.9230    0.4146    3.1963    0.3000    0.4369    0.1501    1.4560    0.0430    0.9942    0.0813
-#> 197:    92.3284   -5.9347   -0.0305    2.4860   -0.9448    0.4115    3.5642    0.3129    0.4314    0.1740    1.3441    0.0473    1.0954    0.0723
-#> 198:    92.3428   -5.9255   -0.0266    2.4822   -0.9463    0.3258    3.4818    0.3185    0.4163    0.1716    1.3868    0.0447    0.9452    0.0788
-#> 199:    92.1692   -6.0683   -0.0227    2.4860   -0.9495    0.2685    4.4044    0.3149    0.4064    0.1824    1.3558    0.0478    1.0294    0.0749
-#> 200:    92.0965   -6.1541   -0.0261    2.4793   -0.9288    0.2210    4.4026    0.3265    0.4200    0.1772    1.3348    0.0441    1.0018    0.0761
-#> 201:    92.1362   -6.1170   -0.0244    2.4776   -0.9237    0.1801    4.4160    0.3276    0.4303    0.1732    1.3479    0.0418    0.9419    0.0809
-#> 202:    92.1114   -6.0898   -0.0233    2.4862   -0.9253    0.1506    4.4494    0.3286    0.4305    0.1656    1.3473    0.0440    0.9394    0.0802
-#> 203:    92.0893   -6.1307   -0.0233    2.4894   -0.9258    0.1510    4.7958    0.3310    0.4233    0.1673    1.3396    0.0457    0.9617    0.0788
-#> 204:    92.0870   -6.0914   -0.0230    2.4867   -0.9234    0.1589    4.6265    0.3316    0.4237    0.1643    1.3478    0.0456    0.9509    0.0793
-#> 205:    92.0800   -6.0960   -0.0228    2.4867   -0.9256    0.1613    4.6319    0.3321    0.4226    0.1623    1.3399    0.0463    0.9547    0.0789
-#> 206:    92.1037   -6.0869   -0.0238    2.4833   -0.9264    0.1648    4.5547    0.3341    0.4186    0.1606    1.3351    0.0466    0.9453    0.0797
-#> 207:    92.1212   -6.0561   -0.0247    2.4821   -0.9299    0.1677    4.3736    0.3363    0.4150    0.1602    1.3394    0.0467    0.9552    0.0790
-#> 208:    92.1203   -6.0351   -0.0260    2.4804   -0.9309    0.1616    4.2520    0.3369    0.4120    0.1613    1.3366    0.0466    0.9667    0.0785
-#> 209:    92.1169   -6.0133   -0.0277    2.4792   -0.9300    0.1596    4.1237    0.3352    0.4111    0.1616    1.3344    0.0464    0.9741    0.0778
-#> 210:    92.1195   -5.9866   -0.0289    2.4752   -0.9287    0.1586    3.9853    0.3352    0.4091    0.1602    1.3410    0.0461    0.9708    0.0778
-#> 211:    92.1243   -5.9458   -0.0316    2.4687   -0.9287    0.1606    3.8383    0.3366    0.4094    0.1607    1.3525    0.0455    0.9759    0.0778
-#> 212:    92.1384   -5.9338   -0.0345    2.4640   -0.9280    0.1635    3.7875    0.3375    0.4105    0.1594    1.3589    0.0454    0.9800    0.0776
-#> 213:    92.1481   -5.9191   -0.0379    2.4587   -0.9269    0.1629    3.7150    0.3375    0.4100    0.1586    1.3673    0.0449    0.9839    0.0775
-#> 214:    92.1523   -5.9189   -0.0408    2.4542   -0.9270    0.1593    3.7061    0.3375    0.4092    0.1579    1.3731    0.0446    0.9847    0.0773
-#> 215:    92.1548   -5.9183   -0.0429    2.4499   -0.9269    0.1604    3.7075    0.3369    0.4095    0.1574    1.3765    0.0442    0.9821    0.0775
-#> 216:    92.1547   -5.9171   -0.0450    2.4455   -0.9270    0.1600    3.6967    0.3368    0.4100    0.1571    1.3811    0.0438    0.9830    0.0776
-#> 217:    92.1556   -5.9141   -0.0468    2.4422   -0.9281    0.1580    3.6732    0.3361    0.4102    0.1578    1.3864    0.0435    0.9995    0.0770
-#> 218:    92.1587   -5.9173   -0.0477    2.4395   -0.9287    0.1545    3.6822    0.3351    0.4112    0.1580    1.3882    0.0432    1.0001    0.0772
-#> 219:    92.1590   -5.9188   -0.0483    2.4374   -0.9303    0.1540    3.6595    0.3341    0.4132    0.1578    1.3889    0.0430    0.9983    0.0775
-#> 220:    92.1614   -5.9303   -0.0493    2.4353   -0.9321    0.1559    3.6914    0.3336    0.4141    0.1581    1.3914    0.0427    1.0003    0.0775
-#> 221:    92.1657   -5.9455   -0.0504    2.4328   -0.9344    0.1585    3.7569    0.3329    0.4140    0.1591    1.3938    0.0424    1.0064    0.0773
-#> 222:    92.1697   -5.9320   -0.0515    2.4306   -0.9358    0.1617    3.6783    0.3321    0.4145    0.1600    1.3992    0.0421    1.0107    0.0772
-#> 223:    92.1754   -5.9205   -0.0525    2.4280   -0.9375    0.1630    3.6233    0.3313    0.4158    0.1604    1.4072    0.0416    1.0216    0.0770
-#> 224:    92.1809   -5.9149   -0.0534    2.4264   -0.9386    0.1623    3.5812    0.3306    0.4167    0.1607    1.4130    0.0413    1.0349    0.0764
-#> 225:    92.1872   -5.9099   -0.0543    2.4243   -0.9390    0.1619    3.5446    0.3299    0.4174    0.1607    1.4152    0.0411    1.0348    0.0766
-#> 226:    92.1935   -5.9046   -0.0554    2.4224   -0.9396    0.1631    3.5046    0.3299    0.4183    0.1608    1.4157    0.0409    1.0375    0.0766
-#> 227:    92.2026   -5.8964   -0.0567    2.4198   -0.9400    0.1637    3.4591    0.3303    0.4183    0.1614    1.4144    0.0408    1.0444    0.0763
-#> 228:    92.2069   -5.8852   -0.0578    2.4175   -0.9407    0.1633    3.4091    0.3308    0.4185    0.1621    1.4144    0.0407    1.0485    0.0763
-#> 229:    92.2122   -5.8844   -0.0591    2.4145   -0.9418    0.1631    3.3899    0.3314    0.4194    0.1622    1.4173    0.0404    1.0514    0.0763
-#> 230:    92.2183   -5.8907   -0.0604    2.4116   -0.9416    0.1640    3.4053    0.3319    0.4202    0.1616    1.4200    0.0401    1.0527    0.0764
-#> 231:    92.2246   -5.8895   -0.0619    2.4087   -0.9422    0.1651    3.3985    0.3323    0.4208    0.1609    1.4234    0.0400    1.0560    0.0762
-#> 232:    92.2282   -5.8840   -0.0632    2.4058   -0.9423    0.1641    3.3771    0.3327    0.4215    0.1609    1.4266    0.0398    1.0585    0.0762
-#> 233:    92.2294   -5.8775   -0.0645    2.4032   -0.9424    0.1620    3.3481    0.3335    0.4216    0.1607    1.4311    0.0395    1.0600    0.0763
-#> 234:    92.2311   -5.8709   -0.0658    2.4006   -0.9421    0.1626    3.3242    0.3343    0.4220    0.1602    1.4340    0.0393    1.0604    0.0764
-#> 235:    92.2312   -5.8656   -0.0668    2.3985   -0.9420    0.1608    3.3023    0.3350    0.4225    0.1596    1.4381    0.0391    1.0600    0.0765
-#> 236:    92.2289   -5.8633   -0.0675    2.3974   -0.9423    0.1599    3.2811    0.3352    0.4227    0.1589    1.4392    0.0390    1.0594    0.0765
-#> 237:    92.2251   -5.8641   -0.0683    2.3960   -0.9435    0.1586    3.2734    0.3351    0.4226    0.1588    1.4403    0.0389    1.0623    0.0765
-#> 238:    92.2242   -5.8633   -0.0690    2.3949   -0.9443    0.1579    3.2547    0.3349    0.4230    0.1590    1.4409    0.0389    1.0659    0.0765
-#> 239:    92.2250   -5.8612   -0.0693    2.3951   -0.9449    0.1558    3.2309    0.3346    0.4234    0.1599    1.4396    0.0389    1.0740    0.0762
-#> 240:    92.2264   -5.8597   -0.0696    2.3949   -0.9446    0.1550    3.2124    0.3342    0.4234    0.1603    1.4401    0.0388    1.0791    0.0760
-#> 241:    92.2281   -5.8562   -0.0699    2.3948   -0.9449    0.1544    3.1933    0.3339    0.4236    0.1604    1.4411    0.0388    1.0825    0.0760
-#> 242:    92.2289   -5.8512   -0.0703    2.3942   -0.9450    0.1534    3.1709    0.3338    0.4235    0.1606    1.4421    0.0388    1.0870    0.0760
-#> 243:    92.2296   -5.8489   -0.0708    2.3934   -0.9446    0.1531    3.1689    0.3342    0.4230    0.1605    1.4423    0.0387    1.0876    0.0760
-#> 244:    92.2311   -5.8446   -0.0715    2.3929   -0.9443    0.1528    3.1630    0.3349    0.4228    0.1604    1.4429    0.0387    1.0916    0.0759
-#> 245:    92.2338   -5.8421   -0.0718    2.3924   -0.9443    0.1528    3.1616    0.3352    0.4224    0.1610    1.4438    0.0387    1.0980    0.0755
-#> 246:    92.2361   -5.8389   -0.0721    2.3918   -0.9439    0.1525    3.1525    0.3354    0.4216    0.1620    1.4438    0.0388    1.1018    0.0753
-#> 247:    92.2374   -5.8388   -0.0724    2.3917   -0.9434    0.1510    3.1605    0.3356    0.4212    0.1629    1.4438    0.0389    1.1050    0.0751
-#> 248:    92.2360   -5.8367   -0.0728    2.3918   -0.9432    0.1505    3.1559    0.3360    0.4207    0.1638    1.4437    0.0389    1.1090    0.0748
-#> 249:    92.2361   -5.8351   -0.0732    2.3914   -0.9435    0.1499    3.1521    0.3363    0.4204    0.1646    1.4433    0.0389    1.1117    0.0748
-#> 250:    92.2353   -5.8349   -0.0733    2.3906   -0.9436    0.1502    3.1607    0.3365    0.4202    0.1646    1.4457    0.0388    1.1107    0.0749
-#> 251:    92.2343   -5.8318   -0.0736    2.3903   -0.9430    0.1494    3.1513    0.3367    0.4201    0.1648    1.4453    0.0387    1.1093    0.0750
-#> 252:    92.2356   -5.8244   -0.0739    2.3895   -0.9424    0.1477    3.1240    0.3369    0.4200    0.1651    1.4460    0.0386    1.1083    0.0750
-#> 253:    92.2367   -5.8188   -0.0742    2.3890   -0.9423    0.1465    3.1025    0.3369    0.4200    0.1649    1.4477    0.0385    1.1092    0.0750
-#> 254:    92.2392   -5.8154   -0.0747    2.3880   -0.9421    0.1458    3.0888    0.3372    0.4195    0.1644    1.4494    0.0384    1.1080    0.0750
-#> 255:    92.2404   -5.8131   -0.0751    2.3870   -0.9417    0.1451    3.0778    0.3375    0.4191    0.1639    1.4501    0.0383    1.1070    0.0751
-#> 256:    92.2408   -5.8109   -0.0753    2.3867   -0.9413    0.1445    3.0740    0.3376    0.4192    0.1633    1.4510    0.0382    1.1064    0.0751
-#> 257:    92.2413   -5.8066   -0.0754    2.3866   -0.9409    0.1446    3.0636    0.3376    0.4191    0.1628    1.4522    0.0382    1.1080    0.0750
-#> 258:    92.2412   -5.8035   -0.0754    2.3869   -0.9404    0.1436    3.0502    0.3372    0.4191    0.1623    1.4534    0.0381    1.1057    0.0751
-#> 259:    92.2399   -5.7996   -0.0753    2.3871   -0.9399    0.1427    3.0357    0.3370    0.4195    0.1621    1.4540    0.0380    1.1037    0.0752
-#> 260:    92.2389   -5.7955   -0.0755    2.3872   -0.9391    0.1420    3.0251    0.3366    0.4199    0.1619    1.4555    0.0380    1.1041    0.0752
-#> 261:    92.2378   -5.7941   -0.0755    2.3875   -0.9385    0.1412    3.0240    0.3362    0.4201    0.1613    1.4575    0.0380    1.1048    0.0751
-#> 262:    92.2361   -5.7920   -0.0756    2.3879   -0.9379    0.1407    3.0182    0.3358    0.4205    0.1607    1.4581    0.0381    1.1047    0.0750
-#> 263:    92.2338   -5.7891   -0.0754    2.3883   -0.9375    0.1407    3.0072    0.3356    0.4211    0.1603    1.4585    0.0381    1.1041    0.0750
-#> 264:    92.2313   -5.7882   -0.0752    2.3886   -0.9371    0.1407    3.0009    0.3355    0.4217    0.1601    1.4574    0.0381    1.1036    0.0750
-#> 265:    92.2312   -5.7843   -0.0752    2.3883   -0.9372    0.1402    2.9872    0.3358    0.4220    0.1599    1.4577    0.0381    1.1026    0.0750
-#> 266:    92.2312   -5.7800   -0.0753    2.3880   -0.9370    0.1396    2.9708    0.3363    0.4223    0.1597    1.4584    0.0381    1.1019    0.0750
-#> 267:    92.2306   -5.7785   -0.0755    2.3878   -0.9372    0.1397    2.9619    0.3368    0.4227    0.1595    1.4578    0.0381    1.1021    0.0750
-#> 268:    92.2287   -5.7803   -0.0758    2.3870   -0.9372    0.1394    2.9777    0.3375    0.4226    0.1594    1.4578    0.0380    1.1032    0.0749
-#> 269:    92.2265   -5.7804   -0.0761    2.3865   -0.9371    0.1399    2.9816    0.3382    0.4226    0.1592    1.4589    0.0380    1.1058    0.0747
-#> 270:    92.2236   -5.7811   -0.0765    2.3860   -0.9369    0.1411    2.9893    0.3386    0.4227    0.1591    1.4597    0.0380    1.1081    0.0745
-#> 271:    92.2211   -5.7793   -0.0769    2.3852   -0.9365    0.1421    2.9888    0.3390    0.4228    0.1591    1.4606    0.0379    1.1083    0.0745
-#> 272:    92.2187   -5.7773   -0.0773    2.3845   -0.9361    0.1423    2.9810    0.3396    0.4232    0.1589    1.4617    0.0378    1.1076    0.0746
-#> 273:    92.2164   -5.7769   -0.0776    2.3838   -0.9356    0.1427    2.9809    0.3402    0.4240    0.1589    1.4615    0.0378    1.1073    0.0746
-#> 274:    92.2145   -5.7763   -0.0778    2.3836   -0.9355    0.1434    2.9795    0.3407    0.4248    0.1589    1.4615    0.0378    1.1069    0.0746
-#> 275:    92.2133   -5.7762   -0.0779    2.3836   -0.9352    0.1436    2.9837    0.3410    0.4253    0.1589    1.4621    0.0378    1.1064    0.0746
-#> 276:    92.2123   -5.7764   -0.0781    2.3835   -0.9348    0.1431    2.9889    0.3414    0.4255    0.1589    1.4632    0.0378    1.1073    0.0746
-#> 277:    92.2113   -5.7771   -0.0781    2.3839   -0.9347    0.1423    2.9925    0.3423    0.4264    0.1589    1.4630    0.0378    1.1104    0.0744
-#> 278:    92.2099   -5.7774   -0.0780    2.3841   -0.9349    0.1418    2.9927    0.3429    0.4270    0.1590    1.4634    0.0378    1.1127    0.0742
-#> 279:    92.2087   -5.7798   -0.0779    2.3844   -0.9352    0.1413    2.9997    0.3437    0.4276    0.1590    1.4630    0.0378    1.1133    0.0742
-#> 280:    92.2077   -5.7802   -0.0778    2.3841   -0.9358    0.1407    2.9971    0.3445    0.4284    0.1586    1.4634    0.0378    1.1136    0.0742
-#> 281:    92.2061   -5.7814   -0.0777    2.3837   -0.9362    0.1401    3.0004    0.3452    0.4291    0.1582    1.4629    0.0378    1.1133    0.0743
-#> 282:    92.2058   -5.7802   -0.0777    2.3834   -0.9363    0.1386    2.9994    0.3459    0.4297    0.1579    1.4634    0.0378    1.1126    0.0743
-#> 283:    92.2057   -5.7780   -0.0778    2.3828   -0.9361    0.1376    2.9917    0.3469    0.4298    0.1576    1.4645    0.0378    1.1147    0.0742
-#> 284:    92.2051   -5.7788   -0.0780    2.3824   -0.9360    0.1367    2.9968    0.3479    0.4300    0.1573    1.4647    0.0378    1.1149    0.0741
-#> 285:    92.2041   -5.7793   -0.0782    2.3821   -0.9362    0.1359    2.9941    0.3487    0.4302    0.1573    1.4653    0.0378    1.1164    0.0740
-#> 286:    92.2040   -5.7803   -0.0783    2.3819   -0.9364    0.1352    2.9957    0.3495    0.4304    0.1573    1.4655    0.0378    1.1180    0.0738
-#> 287:    92.2044   -5.7809   -0.0784    2.3817   -0.9365    0.1348    2.9961    0.3502    0.4304    0.1572    1.4657    0.0379    1.1178    0.0738
-#> 288:    92.2043   -5.7835   -0.0785    2.3814   -0.9366    0.1350    3.0073    0.3509    0.4304    0.1572    1.4658    0.0379    1.1184    0.0738
-#> 289:    92.2041   -5.7845   -0.0787    2.3809   -0.9364    0.1347    3.0126    0.3516    0.4304    0.1571    1.4653    0.0379    1.1190    0.0737
-#> 290:    92.2032   -5.7852   -0.0788    2.3807   -0.9363    0.1349    3.0161    0.3521    0.4304    0.1568    1.4656    0.0379    1.1191    0.0737
-#> 291:    92.2019   -5.7848   -0.0790    2.3802   -0.9363    0.1356    3.0155    0.3528    0.4300    0.1565    1.4664    0.0380    1.1210    0.0736
-#> 292:    92.2012   -5.7846   -0.0792    2.3799   -0.9363    0.1361    3.0167    0.3535    0.4296    0.1563    1.4670    0.0380    1.1223    0.0735
-#> 293:    92.2007   -5.7845   -0.0793    2.3795   -0.9363    0.1365    3.0175    0.3542    0.4291    0.1561    1.4681    0.0380    1.1236    0.0734
-#> 294:    92.2009   -5.7850   -0.0795    2.3791   -0.9360    0.1365    3.0189    0.3550    0.4287    0.1560    1.4682    0.0380    1.1243    0.0733
-#> 295:    92.2009   -5.7865   -0.0797    2.3786   -0.9360    0.1360    3.0279    0.3556    0.4286    0.1558    1.4689    0.0380    1.1243    0.0734
-#> 296:    92.2007   -5.7878   -0.0798    2.3781   -0.9362    0.1358    3.0345    0.3562    0.4283    0.1555    1.4694    0.0379    1.1247    0.0734
-#> 297:    92.1992   -5.7891   -0.0801    2.3774   -0.9364    0.1358    3.0403    0.3568    0.4278    0.1554    1.4699    0.0379    1.1267    0.0734
-#> 298:    92.1978   -5.7892   -0.0803    2.3768   -0.9366    0.1357    3.0383    0.3573    0.4274    0.1553    1.4706    0.0378    1.1276    0.0734
-#> 299:    92.1968   -5.7906   -0.0805    2.3763   -0.9369    0.1353    3.0408    0.3579    0.4269    0.1553    1.4712    0.0378    1.1282    0.0733
-#> 300:    92.1954   -5.7929   -0.0807    2.3760   -0.9369    0.1352    3.0477    0.3583    0.4265    0.1551    1.4716    0.0379    1.1286    0.0733
-#> 301:    92.1941   -5.7934   -0.0809    2.3757   -0.9369    0.1352    3.0483    0.3588    0.4261    0.1548    1.4727    0.0378    1.1288    0.0732
-#> 302:    92.1929   -5.7949   -0.0811    2.3754   -0.9370    0.1354    3.0560    0.3592    0.4256    0.1548    1.4728    0.0379    1.1296    0.0731
-#> 303:    92.1919   -5.7972   -0.0813    2.3751   -0.9368    0.1352    3.0671    0.3597    0.4250    0.1550    1.4730    0.0379    1.1302    0.0731
-#> 304:    92.1906   -5.8018   -0.0814    2.3750   -0.9368    0.1349    3.0935    0.3602    0.4245    0.1552    1.4731    0.0379    1.1314    0.0730
-#> 305:    92.1897   -5.8063   -0.0817    2.3744   -0.9370    0.1350    3.1211    0.3606    0.4238    0.1554    1.4727    0.0379    1.1323    0.0730
-#> 306:    92.1896   -5.8116   -0.0820    2.3740   -0.9373    0.1347    3.1571    0.3610    0.4233    0.1555    1.4727    0.0379    1.1351    0.0728
-#> 307:    92.1895   -5.8156   -0.0822    2.3735   -0.9373    0.1341    3.1826    0.3613    0.4226    0.1552    1.4741    0.0379    1.1374    0.0726
-#> 308:    92.1899   -5.8202   -0.0824    2.3732   -0.9376    0.1338    3.2124    0.3617    0.4220    0.1554    1.4745    0.0379    1.1408    0.0724
-#> 309:    92.1903   -5.8232   -0.0827    2.3728   -0.9377    0.1337    3.2330    0.3620    0.4213    0.1554    1.4749    0.0379    1.1419    0.0724
-#> 310:    92.1902   -5.8249   -0.0828    2.3727   -0.9378    0.1335    3.2463    0.3621    0.4207    0.1554    1.4752    0.0379    1.1435    0.0723
-#> 311:    92.1910   -5.8267   -0.0828    2.3726   -0.9378    0.1335    3.2581    0.3623    0.4200    0.1554    1.4754    0.0379    1.1441    0.0722
-#> 312:    92.1918   -5.8271   -0.0829    2.3726   -0.9378    0.1333    3.2567    0.3624    0.4195    0.1552    1.4751    0.0380    1.1432    0.0723
-#> 313:    92.1926   -5.8260   -0.0829    2.3725   -0.9380    0.1334    3.2497    0.3626    0.4190    0.1552    1.4751    0.0380    1.1434    0.0723
-#> 314:    92.1934   -5.8256   -0.0829    2.3724   -0.9381    0.1330    3.2426    0.3628    0.4185    0.1553    1.4746    0.0380    1.1441    0.0722
-#> 315:    92.1938   -5.8237   -0.0829    2.3724   -0.9384    0.1326    3.2327    0.3630    0.4179    0.1555    1.4746    0.0380    1.1468    0.0721
-#> 316:    92.1950   -5.8235   -0.0829    2.3722   -0.9385    0.1324    3.2283    0.3631    0.4172    0.1557    1.4745    0.0380    1.1476    0.0721
-#> 317:    92.1963   -5.8239   -0.0829    2.3722   -0.9385    0.1322    3.2260    0.3633    0.4167    0.1560    1.4741    0.0380    1.1481    0.0721
-#> 318:    92.1975   -5.8242   -0.0829    2.3722   -0.9387    0.1321    3.2240    0.3634    0.4163    0.1559    1.4740    0.0380    1.1477    0.0722
-#> 319:    92.1990   -5.8250   -0.0829    2.3721   -0.9387    0.1320    3.2215    0.3634    0.4159    0.1560    1.4736    0.0381    1.1496    0.0720
-#> 320:    92.2003   -5.8256   -0.0829    2.3722   -0.9386    0.1322    3.2199    0.3635    0.4155    0.1561    1.4730    0.0381    1.1508    0.0719
-#> 321:    92.2018   -5.8249   -0.0829    2.3723   -0.9386    0.1326    3.2150    0.3635    0.4151    0.1562    1.4727    0.0381    1.1514    0.0718
-#> 322:    92.2031   -5.8239   -0.0829    2.3724   -0.9386    0.1333    3.2081    0.3635    0.4147    0.1561    1.4729    0.0381    1.1527    0.0717
-#> 323:    92.2045   -5.8244   -0.0829    2.3725   -0.9384    0.1336    3.2065    0.3635    0.4143    0.1562    1.4729    0.0381    1.1541    0.0716
-#> 324:    92.2060   -5.8228   -0.0828    2.3726   -0.9383    0.1339    3.1996    0.3635    0.4139    0.1562    1.4729    0.0382    1.1562    0.0714
-#> 325:    92.2071   -5.8212   -0.0828    2.3727   -0.9383    0.1339    3.1921    0.3636    0.4135    0.1563    1.4733    0.0382    1.1580    0.0713
-#> 326:    92.2083   -5.8201   -0.0826    2.3728   -0.9382    0.1340    3.1888    0.3639    0.4134    0.1562    1.4734    0.0382    1.1587    0.0713
-#> 327:    92.2095   -5.8185   -0.0825    2.3729   -0.9379    0.1340    3.1831    0.3641    0.4134    0.1562    1.4737    0.0382    1.1592    0.0713
-#> 328:    92.2105   -5.8188   -0.0823    2.3731   -0.9379    0.1338    3.1836    0.3643    0.4132    0.1561    1.4736    0.0383    1.1589    0.0713
-#> 329:    92.2115   -5.8182   -0.0821    2.3732   -0.9381    0.1339    3.1807    0.3646    0.4129    0.1561    1.4737    0.0383    1.1585    0.0713
-#> 330:    92.2127   -5.8181   -0.0819    2.3734   -0.9381    0.1338    3.1827    0.3648    0.4127    0.1563    1.4735    0.0383    1.1578    0.0714
-#> 331:    92.2134   -5.8180   -0.0815    2.3739   -0.9381    0.1340    3.1837    0.3647    0.4128    0.1566    1.4735    0.0383    1.1575    0.0714
-#> 332:    92.2136   -5.8184   -0.0811    2.3746   -0.9379    0.1340    3.1847    0.3647    0.4130    0.1570    1.4728    0.0384    1.1577    0.0714
-#> 333:    92.2133   -5.8180   -0.0807    2.3753   -0.9376    0.1340    3.1853    0.3646    0.4132    0.1572    1.4725    0.0384    1.1573    0.0714
-#> 334:    92.2136   -5.8173   -0.0803    2.3760   -0.9374    0.1342    3.1838    0.3645    0.4133    0.1576    1.4720    0.0385    1.1570    0.0714
-#> 335:    92.2139   -5.8187   -0.0800    2.3769   -0.9372    0.1344    3.1947    0.3643    0.4135    0.1576    1.4714    0.0386    1.1567    0.0714
-#> 336:    92.2134   -5.8198   -0.0796    2.3777   -0.9370    0.1348    3.2008    0.3641    0.4135    0.1577    1.4706    0.0387    1.1557    0.0714
-#> 337:    92.2130   -5.8201   -0.0792    2.3784   -0.9370    0.1357    3.2050    0.3640    0.4137    0.1579    1.4703    0.0388    1.1558    0.0714
-#> 338:    92.2130   -5.8190   -0.0787    2.3791   -0.9368    0.1362    3.2036    0.3638    0.4139    0.1580    1.4708    0.0388    1.1558    0.0714
-#> 339:    92.2132   -5.8177   -0.0783    2.3798   -0.9368    0.1369    3.2006    0.3637    0.4142    0.1581    1.4712    0.0388    1.1551    0.0714
-#> 340:    92.2137   -5.8167   -0.0778    2.3806   -0.9366    0.1376    3.1984    0.3636    0.4143    0.1581    1.4712    0.0388    1.1540    0.0715
-#> 341:    92.2141   -5.8145   -0.0773    2.3814   -0.9364    0.1378    3.1916    0.3635    0.4142    0.1581    1.4712    0.0389    1.1529    0.0715
-#> 342:    92.2142   -5.8123   -0.0769    2.3821   -0.9364    0.1383    3.1840    0.3634    0.4142    0.1581    1.4718    0.0389    1.1513    0.0716
-#> 343:    92.2139   -5.8109   -0.0764    2.3830   -0.9364    0.1389    3.1806    0.3632    0.4142    0.1581    1.4721    0.0389    1.1501    0.0716
-#> 344:    92.2137   -5.8117   -0.0759    2.3839   -0.9366    0.1390    3.1830    0.3631    0.4144    0.1582    1.4711    0.0390    1.1492    0.0717
-#> 345:    92.2133   -5.8118   -0.0754    2.3849   -0.9368    0.1391    3.1827    0.3630    0.4146    0.1582    1.4703    0.0391    1.1488    0.0717
-#> 346:    92.2127   -5.8113   -0.0748    2.3858   -0.9369    0.1389    3.1793    0.3629    0.4147    0.1581    1.4700    0.0391    1.1475    0.0717
-#> 347:    92.2121   -5.8107   -0.0743    2.3867   -0.9371    0.1386    3.1748    0.3628    0.4149    0.1579    1.4701    0.0392    1.1463    0.0718
-#> 348:    92.2106   -5.8109   -0.0738    2.3876   -0.9374    0.1385    3.1726    0.3626    0.4151    0.1577    1.4704    0.0392    1.1453    0.0719
-#> 349:    92.2096   -5.8111   -0.0732    2.3883   -0.9377    0.1382    3.1703    0.3626    0.4151    0.1575    1.4705    0.0392    1.1448    0.0719
-#> 350:    92.2088   -5.8108   -0.0727    2.3890   -0.9378    0.1380    3.1674    0.3625    0.4152    0.1574    1.4704    0.0392    1.1439    0.0720
-#> 351:    92.2077   -5.8103   -0.0722    2.3899   -0.9379    0.1379    3.1634    0.3623    0.4154    0.1572    1.4701    0.0393    1.1432    0.0720
-#> 352:    92.2069   -5.8103   -0.0718    2.3906   -0.9381    0.1380    3.1626    0.3623    0.4154    0.1570    1.4701    0.0393    1.1425    0.0721
-#> 353:    92.2058   -5.8107   -0.0714    2.3913   -0.9381    0.1382    3.1629    0.3624    0.4154    0.1570    1.4695    0.0394    1.1426    0.0720
-#> 354:    92.2046   -5.8102   -0.0710    2.3921   -0.9381    0.1384    3.1576    0.3624    0.4154    0.1571    1.4691    0.0394    1.1424    0.0720
-#> 355:    92.2034   -5.8084   -0.0707    2.3928   -0.9381    0.1388    3.1501    0.3624    0.4154    0.1570    1.4686    0.0395    1.1414    0.0721
-#> 356:    92.2027   -5.8079   -0.0703    2.3935   -0.9382    0.1392    3.1463    0.3626    0.4155    0.1569    1.4682    0.0396    1.1405    0.0721
-#> 357:    92.2019   -5.8084   -0.0698    2.3943   -0.9382    0.1390    3.1444    0.3628    0.4156    0.1569    1.4665    0.0397    1.1403    0.0721
-#> 358:    92.2014   -5.8085   -0.0694    2.3950   -0.9381    0.1389    3.1413    0.3630    0.4158    0.1569    1.4662    0.0398    1.1398    0.0722
-#> 359:    92.2005   -5.8091   -0.0689    2.3956   -0.9383    0.1387    3.1393    0.3633    0.4159    0.1570    1.4664    0.0398    1.1401    0.0722
-#> 360:    92.1994   -5.8091   -0.0685    2.3962   -0.9385    0.1385    3.1362    0.3635    0.4159    0.1572    1.4664    0.0398    1.1413    0.0722
-#> 361:    92.1983   -5.8094   -0.0682    2.3966   -0.9386    0.1384    3.1340    0.3638    0.4159    0.1573    1.4669    0.0398    1.1420    0.0722
-#> 362:    92.1976   -5.8086   -0.0678    2.3971   -0.9389    0.1380    3.1277    0.3639    0.4160    0.1573    1.4671    0.0398    1.1414    0.0723
-#> 363:    92.1967   -5.8081   -0.0675    2.3976   -0.9389    0.1377    3.1239    0.3641    0.4161    0.1573    1.4669    0.0399    1.1412    0.0723
-#> 364:    92.1960   -5.8073   -0.0671    2.3982   -0.9390    0.1373    3.1208    0.3643    0.4161    0.1572    1.4668    0.0399    1.1411    0.0723
-#> 365:    92.1958   -5.8066   -0.0667    2.3988   -0.9389    0.1369    3.1164    0.3645    0.4160    0.1572    1.4672    0.0399    1.1416    0.0723
-#> 366:    92.1956   -5.8063   -0.0664    2.3992   -0.9390    0.1364    3.1127    0.3650    0.4156    0.1573    1.4674    0.0399    1.1425    0.0723
-#> 367:    92.1952   -5.8056   -0.0661    2.3996   -0.9389    0.1361    3.1082    0.3652    0.4155    0.1574    1.4675    0.0399    1.1416    0.0723
-#> 368:    92.1948   -5.8059   -0.0658    2.4001   -0.9389    0.1359    3.1068    0.3655    0.4154    0.1575    1.4671    0.0399    1.1406    0.0724
-#> 369:    92.1948   -5.8064   -0.0655    2.4005   -0.9388    0.1360    3.1055    0.3658    0.4152    0.1576    1.4669    0.0399    1.1408    0.0724
-#> 370:    92.1951   -5.8072   -0.0652    2.4010   -0.9389    0.1361    3.1060    0.3660    0.4151    0.1576    1.4669    0.0399    1.1406    0.0724
-#> 371:    92.1956   -5.8080   -0.0649    2.4015   -0.9390    0.1362    3.1095    0.3662    0.4150    0.1576    1.4669    0.0400    1.1411    0.0724
-#> 372:    92.1962   -5.8096   -0.0645    2.4020   -0.9390    0.1363    3.1168    0.3665    0.4149    0.1576    1.4667    0.0400    1.1411    0.0724
-#> 373:    92.1968   -5.8098   -0.0642    2.4025   -0.9392    0.1363    3.1154    0.3666    0.4147    0.1576    1.4664    0.0400    1.1418    0.0723
-#> 374:    92.1972   -5.8098   -0.0640    2.4029   -0.9395    0.1363    3.1117    0.3667    0.4146    0.1576    1.4661    0.0401    1.1421    0.0723
-#> 375:    92.1979   -5.8101   -0.0637    2.4032   -0.9397    0.1364    3.1090    0.3668    0.4143    0.1577    1.4654    0.0401    1.1425    0.0723
-#> 376:    92.1981   -5.8106   -0.0635    2.4035   -0.9399    0.1363    3.1084    0.3669    0.4142    0.1576    1.4650    0.0401    1.1423    0.0723
-#> 377:    92.1986   -5.8104   -0.0633    2.4039   -0.9399    0.1360    3.1053    0.3670    0.4142    0.1576    1.4645    0.0402    1.1424    0.0723
-#> 378:    92.1989   -5.8104   -0.0631    2.4043   -0.9399    0.1358    3.1026    0.3671    0.4142    0.1577    1.4638    0.0402    1.1421    0.0723
-#> 379:    92.1990   -5.8114   -0.0628    2.4047   -0.9399    0.1355    3.1068    0.3671    0.4141    0.1577    1.4636    0.0402    1.1413    0.0724
-#> 380:    92.1989   -5.8119   -0.0627    2.4048   -0.9400    0.1351    3.1095    0.3673    0.4136    0.1577    1.4634    0.0402    1.1413    0.0724
-#> 381:    92.1989   -5.8127   -0.0627    2.4048   -0.9400    0.1349    3.1152    0.3676    0.4131    0.1577    1.4631    0.0403    1.1408    0.0723
-#> 382:    92.1994   -5.8126   -0.0627    2.4049   -0.9399    0.1348    3.1188    0.3678    0.4126    0.1576    1.4635    0.0403    1.1403    0.0723
-#> 383:    92.2000   -5.8129   -0.0626    2.4049   -0.9397    0.1346    3.1256    0.3681    0.4120    0.1576    1.4637    0.0403    1.1396    0.0723
-#> 384:    92.2006   -5.8133   -0.0626    2.4050   -0.9396    0.1347    3.1290    0.3683    0.4115    0.1575    1.4641    0.0402    1.1389    0.0723
-#> 385:    92.2015   -5.8131   -0.0626    2.4050   -0.9394    0.1350    3.1287    0.3686    0.4110    0.1575    1.4642    0.0402    1.1382    0.0723
-#> 386:    92.2023   -5.8140   -0.0625    2.4049   -0.9391    0.1349    3.1324    0.3690    0.4104    0.1574    1.4647    0.0402    1.1374    0.0723
-#> 387:    92.2030   -5.8147   -0.0625    2.4050   -0.9390    0.1349    3.1345    0.3693    0.4099    0.1572    1.4652    0.0402    1.1366    0.0724
-#> 388:    92.2040   -5.8157   -0.0625    2.4050   -0.9389    0.1349    3.1381    0.3696    0.4094    0.1570    1.4652    0.0402    1.1362    0.0724
-#> 389:    92.2051   -5.8156   -0.0625    2.4051   -0.9387    0.1349    3.1373    0.3699    0.4090    0.1570    1.4653    0.0402    1.1354    0.0724
-#> 390:    92.2063   -5.8152   -0.0625    2.4051   -0.9386    0.1349    3.1350    0.3702    0.4087    0.1570    1.4655    0.0402    1.1345    0.0725
-#> 391:    92.2076   -5.8160   -0.0625    2.4051   -0.9384    0.1350    3.1380    0.3705    0.4083    0.1571    1.4656    0.0402    1.1341    0.0725
-#> 392:    92.2086   -5.8166   -0.0626    2.4049   -0.9384    0.1349    3.1397    0.3707    0.4081    0.1572    1.4658    0.0402    1.1345    0.0725
-#> 393:    92.2095   -5.8168   -0.0626    2.4047   -0.9383    0.1348    3.1405    0.3708    0.4080    0.1573    1.4659    0.0402    1.1344    0.0725
-#> 394:    92.2107   -5.8174   -0.0627    2.4045   -0.9382    0.1347    3.1433    0.3710    0.4079    0.1575    1.4660    0.0401    1.1342    0.0725
-#> 395:    92.2118   -5.8174   -0.0628    2.4043   -0.9380    0.1346    3.1437    0.3711    0.4078    0.1575    1.4661    0.0401    1.1343    0.0725
-#> 396:    92.2127   -5.8170   -0.0629    2.4041   -0.9379    0.1344    3.1424    0.3712    0.4077    0.1575    1.4664    0.0401    1.1342    0.0725
-#> 397:    92.2137   -5.8161   -0.0630    2.4040   -0.9376    0.1342    3.1386    0.3713    0.4076    0.1577    1.4667    0.0401    1.1341    0.0725
-#> 398:    92.2146   -5.8152   -0.0633    2.4036   -0.9374    0.1341    3.1344    0.3713    0.4075    0.1578    1.4671    0.0401    1.1334    0.0725
-#> 399:    92.2157   -5.8138   -0.0635    2.4032   -0.9373    0.1340    3.1296    0.3714    0.4074    0.1578    1.4678    0.0401    1.1336    0.0726
-#> 400:    92.2165   -5.8131   -0.0638    2.4027   -0.9372    0.1340    3.1262    0.3715    0.4072    0.1579    1.4681    0.0400    1.1332    0.0726
-#> 401:    92.2173   -5.8118   -0.0641    2.4022   -0.9372    0.1341    3.1220    0.3716    0.4069    0.1579    1.4686    0.0400    1.1339    0.0726
-#> 402:    92.2181   -5.8107   -0.0643    2.4018   -0.9370    0.1344    3.1192    0.3718    0.4065    0.1580    1.4694    0.0400    1.1338    0.0726
-#> 403:    92.2190   -5.8099   -0.0646    2.4013   -0.9371    0.1348    3.1166    0.3720    0.4061    0.1581    1.4700    0.0400    1.1344    0.0725
-#> 404:    92.2198   -5.8104   -0.0649    2.4008   -0.9372    0.1348    3.1161    0.3723    0.4058    0.1582    1.4704    0.0399    1.1357    0.0725
-#> 405:    92.2203   -5.8107   -0.0652    2.4004   -0.9372    0.1348    3.1177    0.3725    0.4055    0.1582    1.4705    0.0400    1.1358    0.0724
-#> 406:    92.2204   -5.8103   -0.0653    2.4002   -0.9371    0.1348    3.1157    0.3724    0.4051    0.1582    1.4709    0.0400    1.1361    0.0724
-#> 407:    92.2201   -5.8094   -0.0655    2.4001   -0.9369    0.1348    3.1121    0.3724    0.4048    0.1583    1.4713    0.0400    1.1360    0.0724
-#> 408:    92.2201   -5.8087   -0.0657    2.3999   -0.9368    0.1350    3.1085    0.3724    0.4044    0.1582    1.4714    0.0400    1.1360    0.0723
-#> 409:    92.2201   -5.8083   -0.0658    2.3998   -0.9365    0.1355    3.1073    0.3724    0.4043    0.1582    1.4713    0.0401    1.1358    0.0723
-#> 410:    92.2196   -5.8094   -0.0659    2.3996   -0.9365    0.1361    3.1123    0.3724    0.4041    0.1582    1.4712    0.0401    1.1357    0.0723
-#> 411:    92.2192   -5.8099   -0.0661    2.3994   -0.9366    0.1363    3.1168    0.3724    0.4038    0.1582    1.4715    0.0401    1.1354    0.0723
-#> 412:    92.2187   -5.8105   -0.0662    2.3993   -0.9365    0.1365    3.1215    0.3725    0.4035    0.1582    1.4716    0.0401    1.1359    0.0723
-#> 413:    92.2185   -5.8109   -0.0663    2.3992   -0.9365    0.1367    3.1268    0.3725    0.4031    0.1583    1.4719    0.0401    1.1357    0.0723
-#> 414:    92.2183   -5.8111   -0.0665    2.3987   -0.9365    0.1370    3.1286    0.3727    0.4026    0.1582    1.4724    0.0400    1.1349    0.0723
-#> 415:    92.2181   -5.8122   -0.0667    2.3983   -0.9366    0.1370    3.1351    0.3729    0.4021    0.1581    1.4726    0.0400    1.1341    0.0724
-#> 416:    92.2180   -5.8133   -0.0669    2.3979   -0.9367    0.1372    3.1409    0.3731    0.4015    0.1578    1.4734    0.0400    1.1333    0.0724
-#> 417:    92.2176   -5.8138   -0.0671    2.3976   -0.9368    0.1374    3.1426    0.3733    0.4009    0.1576    1.4739    0.0400    1.1325    0.0724
-#> 418:    92.2173   -5.8150   -0.0673    2.3973   -0.9369    0.1376    3.1479    0.3735    0.4003    0.1575    1.4740    0.0400    1.1316    0.0725
-#> 419:    92.2174   -5.8154   -0.0674    2.3970   -0.9369    0.1375    3.1497    0.3736    0.3998    0.1574    1.4741    0.0400    1.1314    0.0724
-#> 420:    92.2175   -5.8154   -0.0676    2.3968   -0.9369    0.1375    3.1489    0.3737    0.3993    0.1574    1.4742    0.0400    1.1315    0.0724
-#> 421:    92.2176   -5.8154   -0.0678    2.3964   -0.9369    0.1374    3.1485    0.3739    0.3989    0.1573    1.4743    0.0400    1.1312    0.0724
-#> 422:    92.2174   -5.8155   -0.0680    2.3961   -0.9370    0.1375    3.1483    0.3741    0.3985    0.1572    1.4744    0.0400    1.1309    0.0723
-#> 423:    92.2170   -5.8156   -0.0681    2.3958   -0.9371    0.1375    3.1481    0.3742    0.3980    0.1571    1.4741    0.0400    1.1308    0.0723
-#> 424:    92.2169   -5.8168   -0.0683    2.3956   -0.9372    0.1374    3.1524    0.3744    0.3976    0.1571    1.4740    0.0400    1.1316    0.0722
-#> 425:    92.2167   -5.8171   -0.0685    2.3954   -0.9372    0.1373    3.1520    0.3744    0.3972    0.1571    1.4736    0.0401    1.1317    0.0722
-#> 426:    92.2164   -5.8170   -0.0687    2.3951   -0.9372    0.1373    3.1502    0.3745    0.3968    0.1570    1.4734    0.0401    1.1320    0.0722
-#> 427:    92.2166   -5.8169   -0.0688    2.3949   -0.9372    0.1372    3.1480    0.3745    0.3964    0.1570    1.4734    0.0401    1.1317    0.0721
-#> 428:    92.2166   -5.8170   -0.0689    2.3948   -0.9374    0.1371    3.1460    0.3745    0.3959    0.1570    1.4735    0.0401    1.1315    0.0721
-#> 429:    92.2162   -5.8171   -0.0691    2.3946   -0.9374    0.1369    3.1446    0.3745    0.3954    0.1570    1.4736    0.0401    1.1316    0.0721
-#> 430:    92.2158   -5.8178   -0.0692    2.3944   -0.9375    0.1370    3.1464    0.3745    0.3950    0.1570    1.4736    0.0401    1.1314    0.0721
-#> 431:    92.2153   -5.8180   -0.0693    2.3942   -0.9375    0.1371    3.1470    0.3745    0.3946    0.1570    1.4735    0.0401    1.1314    0.0721
-#> 432:    92.2150   -5.8182   -0.0695    2.3940   -0.9375    0.1372    3.1477    0.3746    0.3942    0.1570    1.4735    0.0401    1.1315    0.0721
-#> 433:    92.2145   -5.8189   -0.0696    2.3938   -0.9375    0.1374    3.1512    0.3746    0.3938    0.1571    1.4736    0.0400    1.1323    0.0720
-#> 434:    92.2141   -5.8186   -0.0697    2.3936   -0.9373    0.1376    3.1530    0.3746    0.3933    0.1571    1.4736    0.0400    1.1330    0.0719
-#> 435:    92.2133   -5.8187   -0.0699    2.3934   -0.9373    0.1381    3.1571    0.3747    0.3929    0.1570    1.4738    0.0400    1.1325    0.0720
-#> 436:    92.2129   -5.8180   -0.0700    2.3932   -0.9374    0.1380    3.1544    0.3746    0.3925    0.1570    1.4740    0.0400    1.1332    0.0719
-#> 437:    92.2122   -5.8186   -0.0702    2.3930   -0.9375    0.1380    3.1574    0.3746    0.3921    0.1570    1.4739    0.0400    1.1342    0.0718
-#> 438:    92.2114   -5.8187   -0.0703    2.3928   -0.9376    0.1380    3.1583    0.3745    0.3918    0.1569    1.4740    0.0400    1.1346    0.0718
-#> 439:    92.2104   -5.8181   -0.0705    2.3925   -0.9377    0.1381    3.1568    0.3744    0.3914    0.1568    1.4743    0.0400    1.1352    0.0718
-#> 440:    92.2095   -5.8178   -0.0706    2.3923   -0.9377    0.1381    3.1555    0.3743    0.3910    0.1566    1.4745    0.0400    1.1349    0.0718
-#> 441:    92.2088   -5.8176   -0.0707    2.3923   -0.9378    0.1381    3.1559    0.3742    0.3907    0.1565    1.4748    0.0400    1.1349    0.0718
-#> 442:    92.2081   -5.8172   -0.0708    2.3921   -0.9379    0.1383    3.1539    0.3741    0.3903    0.1564    1.4754    0.0400    1.1350    0.0717
-#> 443:    92.2074   -5.8171   -0.0709    2.3920   -0.9380    0.1387    3.1526    0.3740    0.3901    0.1563    1.4756    0.0400    1.1349    0.0717
-#> 444:    92.2068   -5.8175   -0.0711    2.3918   -0.9380    0.1390    3.1533    0.3739    0.3898    0.1562    1.4758    0.0400    1.1353    0.0717
-#> 445:    92.2061   -5.8180   -0.0712    2.3915   -0.9382    0.1394    3.1529    0.3737    0.3896    0.1562    1.4758    0.0400    1.1355    0.0717
-#> 446:    92.2054   -5.8177   -0.0714    2.3912   -0.9384    0.1398    3.1496    0.3735    0.3894    0.1562    1.4760    0.0399    1.1367    0.0716
-#> 447:    92.2051   -5.8180   -0.0716    2.3910   -0.9385    0.1400    3.1484    0.3734    0.3891    0.1563    1.4762    0.0399    1.1370    0.0715
-#> 448:    92.2053   -5.8189   -0.0717    2.3909   -0.9387    0.1405    3.1499    0.3732    0.3889    0.1563    1.4764    0.0399    1.1377    0.0715
-#> 449:    92.2054   -5.8195   -0.0718    2.3908   -0.9388    0.1411    3.1497    0.3730    0.3887    0.1562    1.4768    0.0399    1.1382    0.0715
-#> 450:    92.2054   -5.8205   -0.0719    2.3906   -0.9390    0.1417    3.1528    0.3728    0.3885    0.1562    1.4769    0.0399    1.1378    0.0715
-#> 451:    92.2053   -5.8213   -0.0720    2.3905   -0.9391    0.1423    3.1544    0.3725    0.3883    0.1561    1.4774    0.0399    1.1379    0.0715
-#> 452:    92.2054   -5.8218   -0.0720    2.3905   -0.9393    0.1426    3.1541    0.3722    0.3882    0.1560    1.4779    0.0398    1.1378    0.0715
-#> 453:    92.2054   -5.8217   -0.0721    2.3903   -0.9395    0.1428    3.1530    0.3721    0.3880    0.1559    1.4785    0.0398    1.1378    0.0715
-#> 454:    92.2053   -5.8214   -0.0722    2.3901   -0.9395    0.1431    3.1508    0.3720    0.3878    0.1559    1.4786    0.0398    1.1375    0.0715
-#> 455:    92.2052   -5.8220   -0.0724    2.3898   -0.9396    0.1433    3.1519    0.3720    0.3875    0.1559    1.4791    0.0398    1.1379    0.0715
-#> 456:    92.2053   -5.8230   -0.0727    2.3894   -0.9397    0.1434    3.1544    0.3720    0.3873    0.1560    1.4793    0.0398    1.1384    0.0714
-#> 457:    92.2053   -5.8240   -0.0729    2.3889   -0.9398    0.1437    3.1568    0.3720    0.3869    0.1559    1.4793    0.0398    1.1393    0.0714
-#> 458:    92.2051   -5.8245   -0.0731    2.3885   -0.9399    0.1440    3.1571    0.3721    0.3865    0.1558    1.4797    0.0397    1.1404    0.0713
-#> 459:    92.2045   -5.8246   -0.0732    2.3882   -0.9402    0.1442    3.1562    0.3721    0.3862    0.1558    1.4801    0.0397    1.1407    0.0713
-#> 460:    92.2040   -5.8244   -0.0734    2.3878   -0.9403    0.1442    3.1536    0.3722    0.3859    0.1558    1.4806    0.0397    1.1406    0.0713
-#> 461:    92.2030   -5.8245   -0.0736    2.3874   -0.9404    0.1444    3.1517    0.3722    0.3856    0.1557    1.4811    0.0397    1.1412    0.0713
-#> 462:    92.2022   -5.8253   -0.0738    2.3870   -0.9405    0.1445    3.1531    0.3723    0.3853    0.1556    1.4817    0.0396    1.1425    0.0712
-#> 463:    92.2014   -5.8260   -0.0740    2.3866   -0.9405    0.1449    3.1545    0.3724    0.3849    0.1556    1.4823    0.0396    1.1441    0.0711
-#> 464:    92.2008   -5.8257   -0.0742    2.3862   -0.9405    0.1453    3.1522    0.3726    0.3845    0.1555    1.4828    0.0396    1.1451    0.0711
-#> 465:    92.2002   -5.8256   -0.0744    2.3859   -0.9404    0.1458    3.1511    0.3727    0.3842    0.1555    1.4830    0.0396    1.1459    0.0710
-#> 466:    92.1997   -5.8256   -0.0747    2.3855   -0.9403    0.1463    3.1516    0.3728    0.3839    0.1555    1.4834    0.0396    1.1476    0.0709
-#> 467:    92.1993   -5.8258   -0.0749    2.3850   -0.9404    0.1468    3.1521    0.3730    0.3836    0.1555    1.4835    0.0395    1.1490    0.0708
-#> 468:    92.1990   -5.8259   -0.0752    2.3846   -0.9404    0.1473    3.1546    0.3731    0.3834    0.1555    1.4837    0.0395    1.1500    0.0708
-#> 469:    92.1987   -5.8263   -0.0753    2.3844   -0.9403    0.1479    3.1598    0.3731    0.3831    0.1555    1.4839    0.0395    1.1504    0.0707
-#> 470:    92.1987   -5.8267   -0.0755    2.3841   -0.9403    0.1482    3.1611    0.3730    0.3829    0.1555    1.4839    0.0395    1.1496    0.0708
-#> 471:    92.1987   -5.8269   -0.0756    2.3839   -0.9404    0.1482    3.1627    0.3730    0.3826    0.1555    1.4839    0.0395    1.1492    0.0708
-#> 472:    92.1983   -5.8269   -0.0758    2.3838   -0.9403    0.1480    3.1618    0.3729    0.3823    0.1555    1.4839    0.0395    1.1493    0.0708
-#> 473:    92.1980   -5.8264   -0.0760    2.3836   -0.9402    0.1478    3.1602    0.3728    0.3820    0.1554    1.4839    0.0395    1.1489    0.0708
-#> 474:    92.1976   -5.8256   -0.0762    2.3834   -0.9402    0.1475    3.1565    0.3727    0.3818    0.1554    1.4842    0.0395    1.1487    0.0708
-#> 475:    92.1971   -5.8252   -0.0763    2.3832   -0.9402    0.1473    3.1543    0.3726    0.3816    0.1553    1.4845    0.0395    1.1487    0.0707
-#> 476:    92.1965   -5.8250   -0.0765    2.3830   -0.9402    0.1469    3.1523    0.3725    0.3814    0.1552    1.4846    0.0395    1.1484    0.0707
-#> 477:    92.1960   -5.8242   -0.0766    2.3827   -0.9402    0.1465    3.1483    0.3724    0.3811    0.1552    1.4849    0.0395    1.1483    0.0708
-#> 478:    92.1955   -5.8236   -0.0767    2.3826   -0.9402    0.1463    3.1447    0.3722    0.3808    0.1553    1.4854    0.0395    1.1481    0.0708
-#> 479:    92.1952   -5.8232   -0.0769    2.3824   -0.9401    0.1462    3.1421    0.3722    0.3805    0.1554    1.4857    0.0395    1.1478    0.0708
-#> 480:    92.1948   -5.8235   -0.0770    2.3822   -0.9400    0.1461    3.1426    0.3721    0.3803    0.1554    1.4862    0.0395    1.1478    0.0708
-#> 481:    92.1947   -5.8240   -0.0772    2.3820   -0.9399    0.1459    3.1455    0.3721    0.3801    0.1554    1.4868    0.0395    1.1483    0.0708
-#> 482:    92.1948   -5.8244   -0.0774    2.3817   -0.9399    0.1456    3.1476    0.3720    0.3799    0.1553    1.4873    0.0395    1.1488    0.0708
-#> 483:    92.1944   -5.8247   -0.0776    2.3815   -0.9397    0.1455    3.1487    0.3719    0.3797    0.1553    1.4876    0.0394    1.1494    0.0708
-#> 484:    92.1941   -5.8249   -0.0778    2.3811   -0.9396    0.1454    3.1493    0.3719    0.3795    0.1554    1.4879    0.0394    1.1501    0.0707
-#> 485:    92.1940   -5.8252   -0.0780    2.3809   -0.9396    0.1453    3.1501    0.3718    0.3793    0.1554    1.4881    0.0394    1.1503    0.0707
-#> 486:    92.1936   -5.8249   -0.0781    2.3807   -0.9395    0.1453    3.1486    0.3717    0.3792    0.1554    1.4884    0.0394    1.1508    0.0707
-#> 487:    92.1935   -5.8248   -0.0783    2.3804   -0.9394    0.1453    3.1485    0.3716    0.3791    0.1553    1.4887    0.0393    1.1507    0.0707
-#> 488:    92.1932   -5.8246   -0.0785    2.3800   -0.9394    0.1454    3.1478    0.3715    0.3788    0.1552    1.4892    0.0393    1.1510    0.0707
-#> 489:    92.1931   -5.8241   -0.0787    2.3796   -0.9394    0.1455    3.1468    0.3715    0.3787    0.1551    1.4895    0.0393    1.1514    0.0706
-#> 490:    92.1934   -5.8242   -0.0790    2.3793   -0.9393    0.1456    3.1478    0.3715    0.3786    0.1551    1.4898    0.0393    1.1528    0.0706
-#> 491:    92.1936   -5.8241   -0.0792    2.3788   -0.9392    0.1455    3.1472    0.3715    0.3785    0.1551    1.4900    0.0393    1.1533    0.0706
-#> 492:    92.1940   -5.8234   -0.0794    2.3783   -0.9391    0.1455    3.1449    0.3714    0.3783    0.1551    1.4903    0.0392    1.1538    0.0705
-#> 493:    92.1943   -5.8230   -0.0797    2.3779   -0.9390    0.1455    3.1426    0.3714    0.3783    0.1552    1.4907    0.0392    1.1541    0.0705
-#> 494:    92.1946   -5.8226   -0.0799    2.3774   -0.9390    0.1458    3.1405    0.3713    0.3782    0.1551    1.4911    0.0392    1.1541    0.0706
-#> 495:    92.1948   -5.8219   -0.0802    2.3770   -0.9391    0.1459    3.1366    0.3712    0.3782    0.1551    1.4916    0.0392    1.1543    0.0706
-#> 496:    92.1948   -5.8213   -0.0804    2.3766   -0.9392    0.1460    3.1331    0.3711    0.3781    0.1552    1.4920    0.0392    1.1556    0.0705
-#> 497:    92.1949   -5.8213   -0.0806    2.3762   -0.9393    0.1462    3.1326    0.3711    0.3780    0.1553    1.4923    0.0391    1.1564    0.0705
-#> 498:    92.1950   -5.8215   -0.0808    2.3758   -0.9394    0.1462    3.1331    0.3710    0.3779    0.1553    1.4926    0.0391    1.1568    0.0705
-#> 499:    92.1953   -5.8219   -0.0810    2.3754   -0.9395    0.1461    3.1343    0.3709    0.3778    0.1554    1.4929    0.0391    1.1567    0.0705
-#> 500:    92.1957   -5.8232   -0.0812    2.3751   -0.9395    0.1459    3.1411    0.3709    0.3776    0.1554    1.4931    0.0391    1.1575    0.0705
-#> Calculating covariance matrix
-#> 
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Calculating residuals/tables
-#> done
-f_nlmixr_fomc_sfo_focei_obs_tc <- nlmixr(f_mmkin_tc["FOMC-SFO", ], est = "focei",
-  error_model = "obs_tc")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
-#> F: Forward difference gradient approximation
-#> C: Central difference gradient approximation
-#> M: Mixed forward and central difference gradient approximation
-#> Unscaled parameters for Omegas=chol(solve(omega));
-#> Diagonals are transformed, as specified by foceiControl(diagXform=)
-#> |-----+---------------+-----------+-----------+-----------+-----------|
-#> |    #| Objective Fun |  parent_0 |  log_k_A1 |f_parent_qlogis | log_alpha |
-#> |.....................|  log_beta |sigma_low_parent |rsd_high_parent |sigma_low_A1 |
-#> |.....................|rsd_high_A1 |        o1 |        o2 |        o3 |
-#> |.....................|        o4 |        o5 |...........|...........|
-#> |    1|     500.20030 |     1.000 |    -1.000 |   -0.9113 |   -0.8944 |
-#> |.....................|   -0.8454 |   -0.8678 |   -0.8916 |   -0.8678 |
-#> |.....................|   -0.8916 |   -0.8767 |   -0.8743 |   -0.8675 |
-#> |.....................|   -0.8704 |   -0.8704 |...........|...........|
-#> |    U|      500.2003 |     93.00 |    -5.300 |   -0.9400 |   -0.1100 |
-#> |.....................|     2.300 |     1.200 |   0.03000 |     1.200 |
-#> |.....................|   0.03000 |    0.7598 |    0.8758 |     1.214 |
-#> |.....................|     1.068 |     1.071 |...........|...........|
-#> |    X|      500.2003 |     93.00 |  0.004992 |    0.2809 |    0.8958 |
-#> |.....................|     9.974 |     1.200 |   0.03000 |     1.200 |
-#> |.....................|   0.03000 |    0.7598 |    0.8758 |     1.214 |
-#> |.....................|     1.068 |     1.071 |...........|...........|
-#> |    G|    Gill Diff. |     48.88 |     2.383 |    0.1231 |    0.1986 |
-#> |.....................|    0.1571 |    -68.85 |    -20.11 |     3.616 |
-#> |.....................|    -2.292 |    0.6250 |     11.41 |    -12.48 |
-#> |.....................|    -9.903 |    -10.91 |...........|...........|
-#> |    2|     2737.7532 |    0.4556 |    -1.027 |   -0.9127 |   -0.8966 |
-#> |.....................|   -0.8471 |   -0.1009 |   -0.6676 |   -0.9080 |
-#> |.....................|   -0.8660 |   -0.8837 |    -1.001 |   -0.7285 |
-#> |.....................|   -0.7601 |   -0.7489 |...........|...........|
-#> |    U|     2737.7532 |     42.37 |    -5.327 |   -0.9413 |   -0.1122 |
-#> |.....................|     2.298 |     1.660 |   0.03336 |     1.176 |
-#> |.....................|   0.03038 |    0.7545 |    0.7645 |     1.383 |
-#> |.....................|     1.185 |     1.201 |...........|...........|
-#> |    X|     2737.7532 |     42.37 |  0.004861 |    0.2806 |    0.8939 |
-#> |.....................|     9.957 |     1.660 |   0.03336 |     1.176 |
-#> |.....................|   0.03038 |    0.7545 |    0.7645 |     1.383 |
-#> |.....................|     1.185 |     1.201 |...........|...........|
-#> |    3|     513.07755 |    0.9456 |    -1.003 |   -0.9114 |   -0.8946 |
-#> |.....................|   -0.8455 |   -0.7911 |   -0.8692 |   -0.8718 |
-#> |.....................|   -0.8890 |   -0.8774 |   -0.8871 |   -0.8536 |
-#> |.....................|   -0.8594 |   -0.8582 |...........|...........|
-#> |    U|     513.07755 |     87.94 |    -5.303 |   -0.9401 |   -0.1102 |
-#> |.....................|     2.300 |     1.246 |   0.03034 |     1.198 |
-#> |.....................|   0.03004 |    0.7593 |    0.8646 |     1.231 |
-#> |.....................|     1.079 |     1.084 |...........|...........|
-#> |    X|     513.07755 |     87.94 |  0.004978 |    0.2809 |    0.8956 |
-#> |.....................|     9.972 |     1.246 |   0.03034 |     1.198 |
-#> |.....................|   0.03004 |    0.7593 |    0.8646 |     1.231 |
-#> |.....................|     1.079 |     1.084 |...........|...........|
-#> |    4|     499.28604 |    0.9888 |    -1.001 |   -0.9113 |   -0.8945 |
-#> |.....................|   -0.8454 |   -0.8520 |   -0.8870 |   -0.8686 |
-#> |.....................|   -0.8910 |   -0.8769 |   -0.8770 |   -0.8646 |
-#> |.....................|   -0.8682 |   -0.8679 |...........|...........|
-#> |    U|     499.28604 |     91.96 |    -5.301 |   -0.9400 |   -0.1100 |
-#> |.....................|     2.300 |     1.209 |   0.03007 |     1.200 |
-#> |.....................|   0.03001 |    0.7597 |    0.8735 |     1.218 |
-#> |.....................|     1.070 |     1.074 |...........|...........|
-#> |    X|     499.28604 |     91.96 |  0.004989 |    0.2809 |    0.8958 |
-#> |.....................|     9.974 |     1.209 |   0.03007 |     1.200 |
-#> |.....................|   0.03001 |    0.7597 |    0.8735 |     1.218 |
-#> |.....................|     1.070 |     1.074 |...........|...........|
-#> |    F| Forward Diff. |    -111.5 |     2.236 |   -0.2057 |    0.1035 |
-#> |.....................|   -0.1971 |    -66.17 |    -21.17 |     4.107 |
-#> |.....................|    -1.586 |     1.583 |     8.991 |    -11.70 |
-#> |.....................|    -9.625 |    -10.49 |...........|...........|
-#> |    5|     497.76004 |     1.001 |    -1.001 |   -0.9113 |   -0.8945 |
-#> |.....................|   -0.8454 |   -0.8366 |   -0.8822 |   -0.8695 |
-#> |.....................|   -0.8906 |   -0.8771 |   -0.8792 |   -0.8619 |
-#> |.....................|   -0.8660 |   -0.8654 |...........|...........|
-#> |    U|     497.76004 |     93.05 |    -5.301 |   -0.9400 |   -0.1101 |
-#> |.....................|     2.300 |     1.219 |   0.03014 |     1.199 |
-#> |.....................|   0.03001 |    0.7595 |    0.8715 |     1.221 |
-#> |.....................|     1.072 |     1.076 |...........|...........|
-#> |    X|     497.76004 |     93.05 |  0.004986 |    0.2809 |    0.8958 |
-#> |.....................|     9.974 |     1.219 |   0.03014 |     1.199 |
-#> |.....................|   0.03001 |    0.7595 |    0.8715 |     1.221 |
-#> |.....................|     1.072 |     1.076 |...........|...........|
-#> |    F| Forward Diff. |     56.91 |     2.356 |    0.1468 |    0.2109 |
-#> |.....................|    0.1761 |    -64.61 |    -18.67 |     3.291 |
-#> |.....................|    -1.680 |     1.108 |     8.338 |    -11.70 |
-#> |.....................|    -9.518 |    -10.47 |...........|...........|
-#> |    6|     496.73820 |    0.9899 |    -1.002 |   -0.9113 |   -0.8945 |
-#> |.....................|   -0.8454 |   -0.8205 |   -0.8775 |   -0.8703 |
-#> |.....................|   -0.8902 |   -0.8774 |   -0.8813 |   -0.8590 |
-#> |.....................|   -0.8636 |   -0.8628 |...........|...........|
-#> |    U|      496.7382 |     92.06 |    -5.302 |   -0.9400 |   -0.1101 |
-#> |.....................|     2.300 |     1.228 |   0.03021 |     1.198 |
-#> |.....................|   0.03002 |    0.7593 |    0.8696 |     1.225 |
-#> |.....................|     1.075 |     1.079 |...........|...........|
-#> |    X|      496.7382 |     92.06 |  0.004983 |    0.2809 |    0.8957 |
-#> |.....................|     9.974 |     1.228 |   0.03021 |     1.198 |
-#> |.....................|   0.03002 |    0.7593 |    0.8696 |     1.225 |
-#> |.....................|     1.075 |     1.079 |...........|...........|
-#> |    F| Forward Diff. |    -94.52 |     2.222 |   -0.1721 |    0.1131 |
-#> |.....................|   -0.1712 |    -62.76 |    -19.55 |     3.974 |
-#> |.....................|    -1.718 |     1.304 |     7.360 |    -11.47 |
-#> |.....................|    -9.402 |    -10.21 |...........|...........|
-#> |    7|     495.33979 |     1.001 |    -1.002 |   -0.9113 |   -0.8946 |
-#> |.....................|   -0.8454 |   -0.8044 |   -0.8726 |   -0.8713 |
-#> |.....................|   -0.8897 |   -0.8777 |   -0.8834 |   -0.8560 |
-#> |.....................|   -0.8612 |   -0.8602 |...........|...........|
-#> |    U|     495.33979 |     93.05 |    -5.302 |   -0.9400 |   -0.1102 |
-#> |.....................|     2.300 |     1.238 |   0.03028 |     1.198 |
-#> |.....................|   0.03003 |    0.7591 |    0.8679 |     1.228 |
-#> |.....................|     1.077 |     1.082 |...........|...........|
-#> |    X|     495.33979 |     93.05 |  0.004981 |    0.2809 |    0.8957 |
-#> |.....................|     9.974 |     1.238 |   0.03028 |     1.198 |
-#> |.....................|   0.03003 |    0.7591 |    0.8679 |     1.228 |
-#> |.....................|     1.077 |     1.082 |...........|...........|
-#> |    F| Forward Diff. |     56.11 |     2.327 |    0.1520 |    0.2091 |
-#> |.....................|    0.1742 |    -61.13 |    -17.23 |     3.435 |
-#> |.....................|    -1.620 |     1.132 |     9.399 |    -11.44 |
-#> |.....................|    -9.328 |    -10.19 |...........|...........|
-#> |    8|     494.31617 |    0.9904 |    -1.003 |   -0.9113 |   -0.8946 |
-#> |.....................|   -0.8455 |   -0.7881 |   -0.8680 |   -0.8722 |
-#> |.....................|   -0.8893 |   -0.8780 |   -0.8859 |   -0.8530 |
-#> |.....................|   -0.8587 |   -0.8575 |...........|...........|
-#> |    U|     494.31617 |     92.11 |    -5.303 |   -0.9400 |   -0.1102 |
-#> |.....................|     2.300 |     1.248 |   0.03035 |     1.197 |
-#> |.....................|   0.03003 |    0.7589 |    0.8657 |     1.232 |
-#> |.....................|     1.080 |     1.085 |...........|...........|
-#> |    X|     494.31617 |     92.11 |  0.004977 |    0.2809 |    0.8956 |
-#> |.....................|     9.973 |     1.248 |   0.03035 |     1.197 |
-#> |.....................|   0.03003 |    0.7589 |    0.8657 |     1.232 |
-#> |.....................|     1.080 |     1.085 |...........|...........|
-#> |    F| Forward Diff. |    -86.81 |     2.198 |   -0.1566 |    0.1238 |
-#> |.....................|   -0.1638 |    -59.37 |    -18.02 |     4.057 |
-#> |.....................|    -1.591 |     1.325 |     8.479 |    -11.19 |
-#> |.....................|    -9.201 |    -9.937 |...........|...........|
-#> |    9|     493.00423 |     1.001 |    -1.003 |   -0.9113 |   -0.8947 |
-#> |.....................|   -0.8454 |   -0.7718 |   -0.8631 |   -0.8732 |
-#> |.....................|   -0.8888 |   -0.8783 |   -0.8883 |   -0.8499 |
-#> |.....................|   -0.8562 |   -0.8548 |...........|...........|
-#> |    U|     493.00423 |     93.05 |    -5.303 |   -0.9400 |   -0.1103 |
-#> |.....................|     2.300 |     1.258 |   0.03043 |     1.197 |
-#> |.....................|   0.03004 |    0.7586 |    0.8635 |     1.236 |
-#> |.....................|     1.083 |     1.088 |...........|...........|
-#> |    X|     493.00423 |     93.05 |  0.004974 |    0.2809 |    0.8956 |
-#> |.....................|     9.974 |     1.258 |   0.03043 |     1.197 |
-#> |.....................|   0.03004 |    0.7586 |    0.8635 |     1.236 |
-#> |.....................|     1.083 |     1.088 |...........|...........|
-#> |    F| Forward Diff. |     54.84 |     2.286 |    0.1404 |    0.2142 |
-#> |.....................|    0.1628 |    -57.96 |    -15.94 |     3.372 |
-#> |.....................|    -1.642 |     1.184 |     9.036 |    -11.17 |
-#> |.....................|    -9.110 |    -9.901 |...........|...........|
-#> |   10|     491.99601 |    0.9908 |    -1.004 |   -0.9114 |   -0.8947 |
-#> |.....................|   -0.8455 |   -0.7552 |   -0.8585 |   -0.8742 |
-#> |.....................|   -0.8884 |   -0.8786 |   -0.8910 |   -0.8467 |
-#> |.....................|   -0.8536 |   -0.8520 |...........|...........|
-#> |    U|     491.99601 |     92.15 |    -5.304 |   -0.9401 |   -0.1103 |
-#> |.....................|     2.300 |     1.268 |   0.03050 |     1.196 |
-#> |.....................|   0.03005 |    0.7584 |    0.8612 |     1.239 |
-#> |.....................|     1.085 |     1.091 |...........|...........|
-#> |    X|     491.99601 |     92.15 |  0.004971 |    0.2809 |    0.8956 |
-#> |.....................|     9.973 |     1.268 |   0.03050 |     1.196 |
-#> |.....................|   0.03005 |    0.7584 |    0.8612 |     1.239 |
-#> |.....................|     1.085 |     1.091 |...........|...........|
-#> |    F| Forward Diff. |    -80.67 |     2.171 |   -0.1367 |    0.1256 |
-#> |.....................|   -0.1610 |    -56.13 |    -16.61 |     4.047 |
-#> |.....................|    -1.607 |     1.226 |     8.142 |    -10.92 |
-#> |.....................|    -8.982 |    -9.644 |...........|...........|
-#> |   11|     490.76421 |     1.000 |    -1.005 |   -0.9113 |   -0.8948 |
-#> |.....................|   -0.8455 |   -0.7388 |   -0.8538 |   -0.8754 |
-#> |.....................|   -0.8879 |   -0.8790 |   -0.8935 |   -0.8435 |
-#> |.....................|   -0.8510 |   -0.8492 |...........|...........|
-#> |    U|     490.76421 |     93.04 |    -5.305 |   -0.9401 |   -0.1104 |
-#> |.....................|     2.300 |     1.277 |   0.03057 |     1.195 |
-#> |.....................|   0.03006 |    0.7581 |    0.8590 |     1.243 |
-#> |.....................|     1.088 |     1.094 |...........|...........|
-#> |    X|     490.76421 |     93.04 |  0.004968 |    0.2809 |    0.8955 |
-#> |.....................|     9.973 |     1.277 |   0.03057 |     1.195 |
-#> |.....................|   0.03006 |    0.7581 |    0.8590 |     1.243 |
-#> |.....................|     1.088 |     1.094 |...........|...........|
-#> |    F| Forward Diff. |     54.34 |     2.256 |    0.1715 |    0.2224 |
-#> |.....................|    0.1653 |    -54.87 |    -14.72 |     3.299 |
-#> |.....................|    -1.777 |     1.023 |     8.651 |    -10.90 |
-#> |.....................|    -8.887 |    -9.594 |...........|...........|
-#> |   12|     489.76286 |    0.9913 |    -1.005 |   -0.9114 |   -0.8948 |
-#> |.....................|   -0.8455 |   -0.7220 |   -0.8492 |   -0.8764 |
-#> |.....................|   -0.8873 |   -0.8793 |   -0.8962 |   -0.8402 |
-#> |.....................|   -0.8483 |   -0.8462 |...........|...........|
-#> |    U|     489.76286 |     92.19 |    -5.305 |   -0.9401 |   -0.1104 |
-#> |.....................|     2.300 |     1.287 |   0.03063 |     1.195 |
-#> |.....................|   0.03006 |    0.7579 |    0.8566 |     1.247 |
-#> |.....................|     1.091 |     1.097 |...........|...........|
-#> |    X|     489.76286 |     92.19 |  0.004965 |    0.2809 |    0.8955 |
-#> |.....................|     9.973 |     1.287 |   0.03063 |     1.195 |
-#> |.....................|   0.03006 |    0.7579 |    0.8566 |     1.247 |
-#> |.....................|     1.091 |     1.097 |...........|...........|
-#> |    F| Forward Diff. |    -73.18 |     2.145 |   -0.1190 |    0.1261 |
-#> |.....................|   -0.1580 |    -53.08 |    -15.27 |     4.015 |
-#> |.....................|    -1.639 |     1.110 |     7.813 |    -10.65 |
-#> |.....................|    -8.743 |    -9.338 |...........|...........|
-#> |   13|     488.61493 |     1.000 |    -1.006 |   -0.9114 |   -0.8949 |
-#> |.....................|   -0.8455 |   -0.7053 |   -0.8446 |   -0.8776 |
-#> |.....................|   -0.8867 |   -0.8796 |   -0.8989 |   -0.8368 |
-#> |.....................|   -0.8455 |   -0.8433 |...........|...........|
-#> |    U|     488.61493 |     93.04 |    -5.306 |   -0.9401 |   -0.1105 |
-#> |.....................|     2.300 |     1.297 |   0.03070 |     1.194 |
-#> |.....................|   0.03007 |    0.7577 |    0.8543 |     1.252 |
-#> |.....................|     1.094 |     1.100 |...........|...........|
-#> |    X|     488.61493 |     93.04 |  0.004961 |    0.2809 |    0.8954 |
-#> |.....................|     9.973 |     1.297 |   0.03070 |     1.194 |
-#> |.....................|   0.03007 |    0.7577 |    0.8543 |     1.252 |
-#> |.....................|     1.094 |     1.100 |...........|...........|
-#> |    F| Forward Diff. |     54.41 |     2.230 |    0.1889 |    0.2376 |
-#> |.....................|    0.1637 |    -52.01 |    -13.54 |     3.223 |
-#> |.....................|    -1.937 |    0.8847 |     10.07 |    -10.59 |
-#> |.....................|    -8.650 |    -9.282 |...........|...........|
-#> |   14|     487.61806 |    0.9919 |    -1.007 |   -0.9114 |   -0.8949 |
-#> |.....................|   -0.8455 |   -0.6884 |   -0.8402 |   -0.8788 |
-#> |.....................|   -0.8861 |   -0.8798 |   -0.9022 |   -0.8333 |
-#> |.....................|   -0.8427 |   -0.8402 |...........|...........|
-#> |    U|     487.61806 |     92.24 |    -5.307 |   -0.9401 |   -0.1105 |
-#> |.....................|     2.300 |     1.308 |   0.03077 |     1.193 |
-#> |.....................|   0.03008 |    0.7575 |    0.8514 |     1.256 |
-#> |.....................|     1.097 |     1.103 |...........|...........|
-#> |    X|     487.61806 |     92.24 |  0.004958 |    0.2809 |    0.8953 |
-#> |.....................|     9.973 |     1.308 |   0.03077 |     1.193 |
-#> |.....................|   0.03008 |    0.7575 |    0.8514 |     1.256 |
-#> |.....................|     1.097 |     1.103 |...........|...........|
-#> |    F| Forward Diff. |    -64.97 |     2.116 |  -0.09941 |    0.1372 |
-#> |.....................|   -0.1475 |    -50.35 |    -14.02 |     3.916 |
-#> |.....................|    -1.790 |    0.8979 |     9.163 |    -10.32 |
-#> |.....................|    -8.505 |    -9.022 |...........|...........|
-#> |   15|     486.55968 |     1.001 |    -1.008 |   -0.9114 |   -0.8950 |
-#> |.....................|   -0.8455 |   -0.6717 |   -0.8358 |   -0.8800 |
-#> |.....................|   -0.8854 |   -0.8801 |   -0.9058 |   -0.8297 |
-#> |.....................|   -0.8398 |   -0.8372 |...........|...........|
-#> |    U|     486.55968 |     93.05 |    -5.308 |   -0.9401 |   -0.1106 |
-#> |.....................|     2.300 |     1.318 |   0.03084 |     1.193 |
-#> |.....................|   0.03009 |    0.7573 |    0.8482 |     1.260 |
-#> |.....................|     1.100 |     1.107 |...........|...........|
-#> |    X|     486.55968 |     93.05 |  0.004954 |    0.2809 |    0.8953 |
-#> |.....................|     9.973 |     1.318 |   0.03084 |     1.193 |
-#> |.....................|   0.03009 |    0.7573 |    0.8482 |     1.260 |
-#> |.....................|     1.100 |     1.107 |...........|...........|
-#> |    F| Forward Diff. |     55.08 |     2.188 |    0.1916 |    0.2341 |
-#> |.....................|    0.1660 |    -48.95 |    -12.27 |     3.347 |
-#> |.....................|    -1.726 |    0.9589 |     6.446 |    -10.30 |
-#> |.....................|    -8.390 |    -8.950 |...........|...........|
-#> |   16|     485.60262 |    0.9920 |    -1.008 |   -0.9115 |   -0.8951 |
-#> |.....................|   -0.8455 |   -0.6547 |   -0.8316 |   -0.8813 |
-#> |.....................|   -0.8847 |   -0.8804 |   -0.9083 |   -0.8260 |
-#> |.....................|   -0.8367 |   -0.8340 |...........|...........|
-#> |    U|     485.60262 |     92.26 |    -5.308 |   -0.9402 |   -0.1107 |
-#> |.....................|     2.300 |     1.328 |   0.03090 |     1.192 |
-#> |.....................|   0.03010 |    0.7571 |    0.8460 |     1.265 |
-#> |.....................|     1.104 |     1.110 |...........|...........|
-#> |    X|     485.60262 |     92.26 |  0.004950 |    0.2809 |    0.8952 |
-#> |.....................|     9.973 |     1.328 |   0.03090 |     1.192 |
-#> |.....................|   0.03010 |    0.7571 |    0.8460 |     1.265 |
-#> |.....................|     1.104 |     1.110 |...........|...........|
-#> |    F| Forward Diff. |    -62.47 |     2.078 |  -0.09882 |    0.1294 |
-#> |.....................|   -0.1587 |    -47.42 |    -12.81 |     3.926 |
-#> |.....................|    -1.683 |    0.9415 |     5.611 |    -10.02 |
-#> |.....................|    -8.237 |    -8.679 |...........|...........|
-#> |   17|     484.58535 |     1.000 |    -1.009 |   -0.9115 |   -0.8952 |
-#> |.....................|   -0.8455 |   -0.6375 |   -0.8274 |   -0.8829 |
-#> |.....................|   -0.8840 |   -0.8807 |   -0.9099 |   -0.8222 |
-#> |.....................|   -0.8336 |   -0.8307 |...........|...........|
-#> |    U|     484.58535 |     93.02 |    -5.309 |   -0.9402 |   -0.1107 |
-#> |.....................|     2.300 |     1.338 |   0.03096 |     1.191 |
-#> |.....................|   0.03011 |    0.7568 |    0.8446 |     1.269 |
-#> |.....................|     1.107 |     1.114 |...........|...........|
-#> |    X|     484.58535 |     93.02 |  0.004946 |    0.2809 |    0.8952 |
-#> |.....................|     9.973 |     1.338 |   0.03096 |     1.191 |
-#> |.....................|   0.03011 |    0.7568 |    0.8446 |     1.269 |
-#> |.....................|     1.107 |     1.114 |...........|...........|
-#> |    F| Forward Diff. |     50.15 |     2.155 |    0.1960 |    0.2225 |
-#> |.....................|    0.1509 |    -46.14 |    -11.19 |     3.405 |
-#> |.....................|    -1.652 |     1.035 |     7.536 |    -9.951 |
-#> |.....................|    -8.121 |    -8.609 |...........|...........|
-#> |   18|     483.66860 |    0.9923 |    -1.010 |   -0.9115 |   -0.8952 |
-#> |.....................|   -0.8455 |   -0.6203 |   -0.8235 |   -0.8844 |
-#> |.....................|   -0.8833 |   -0.8810 |   -0.9123 |   -0.8182 |
-#> |.....................|   -0.8303 |   -0.8273 |...........|...........|
-#> |    U|      483.6686 |     92.29 |    -5.310 |   -0.9402 |   -0.1108 |
-#> |.....................|     2.300 |     1.348 |   0.03102 |     1.190 |
-#> |.....................|   0.03012 |    0.7565 |    0.8425 |     1.274 |
-#> |.....................|     1.110 |     1.117 |...........|...........|
-#> |    X|      483.6686 |     92.29 |  0.004942 |    0.2809 |    0.8951 |
-#> |.....................|     9.973 |     1.348 |   0.03102 |     1.190 |
-#> |.....................|   0.03012 |    0.7565 |    0.8425 |     1.274 |
-#> |.....................|     1.110 |     1.117 |...........|...........|
-#> |    F| Forward Diff. |    -57.62 |     2.059 |  -0.07549 |    0.1395 |
-#> |.....................|   -0.1501 |    -44.74 |    -11.66 |     3.913 |
-#> |.....................|    -1.664 |    0.8845 |     6.781 |    -9.703 |
-#> |.....................|    -7.961 |    -8.325 |...........|...........|
-#> |   19|     482.71012 |     1.000 |    -1.011 |   -0.9115 |   -0.8953 |
-#> |.....................|   -0.8455 |   -0.6032 |   -0.8198 |   -0.8861 |
-#> |.....................|   -0.8825 |   -0.8814 |   -0.9153 |   -0.8141 |
-#> |.....................|   -0.8270 |   -0.8239 |...........|...........|
-#> |    U|     482.71012 |     93.02 |    -5.311 |   -0.9402 |   -0.1109 |
-#> |.....................|     2.300 |     1.359 |   0.03108 |     1.189 |
-#> |.....................|   0.03014 |    0.7563 |    0.8399 |     1.279 |
-#> |.....................|     1.114 |     1.121 |...........|...........|
-#> |    X|     482.71012 |     93.02 |  0.004937 |    0.2809 |    0.8950 |
-#> |.....................|     9.973 |     1.359 |   0.03108 |     1.189 |
-#> |.....................|   0.03014 |    0.7563 |    0.8399 |     1.279 |
-#> |.....................|     1.114 |     1.121 |...........|...........|
-#> |    F| Forward Diff. |     48.98 |     2.122 |    0.2043 |    0.2315 |
-#> |.....................|    0.1449 |    -43.47 |    -10.15 |     3.365 |
-#> |.....................|    -1.703 |    0.9582 |     7.160 |    -9.600 |
-#> |.....................|    -7.838 |    -8.245 |...........|...........|
-#> |   20|     481.83107 |    0.9926 |    -1.012 |   -0.9116 |   -0.8954 |
-#> |.....................|   -0.8455 |   -0.5860 |   -0.8164 |   -0.8879 |
-#> |.....................|   -0.8817 |   -0.8818 |   -0.9184 |   -0.8098 |
-#> |.....................|   -0.8235 |   -0.8203 |...........|...........|
-#> |    U|     481.83107 |     92.31 |    -5.312 |   -0.9403 |   -0.1110 |
-#> |.....................|     2.300 |     1.369 |   0.03113 |     1.188 |
-#> |.....................|   0.03015 |    0.7560 |    0.8372 |     1.284 |
-#> |.....................|     1.118 |     1.125 |...........|...........|
-#> |    X|     481.83107 |     92.31 |  0.004932 |    0.2808 |    0.8949 |
-#> |.....................|     9.973 |     1.369 |   0.03113 |     1.188 |
-#> |.....................|   0.03015 |    0.7560 |    0.8372 |     1.284 |
-#> |.....................|     1.118 |     1.125 |...........|...........|
-#> |    F| Forward Diff. |    -54.27 |     2.027 |  -0.06740 |    0.1414 |
-#> |.....................|   -0.1465 |    -41.84 |    -10.48 |     3.798 |
-#> |.....................|    -1.730 |    0.8044 |     6.401 |    -9.335 |
-#> |.....................|    -7.662 |    -7.960 |...........|...........|
-#> |   21|     480.92878 |     1.000 |    -1.013 |   -0.9117 |   -0.8955 |
-#> |.....................|   -0.8455 |   -0.5689 |   -0.8133 |   -0.8899 |
-#> |.....................|   -0.8807 |   -0.8821 |   -0.9215 |   -0.8053 |
-#> |.....................|   -0.8199 |   -0.8166 |...........|...........|
-#> |    U|     480.92878 |     93.01 |    -5.313 |   -0.9403 |   -0.1111 |
-#> |.....................|     2.300 |     1.379 |   0.03117 |     1.187 |
-#> |.....................|   0.03016 |    0.7557 |    0.8345 |     1.290 |
-#> |.....................|     1.122 |     1.129 |...........|...........|
-#> |    X|     480.92878 |     93.01 |  0.004927 |    0.2808 |    0.8948 |
-#> |.....................|     9.973 |     1.379 |   0.03117 |     1.187 |
-#> |.....................|   0.03016 |    0.7557 |    0.8345 |     1.290 |
-#> |.....................|     1.122 |     1.129 |...........|...........|
-#> |    F| Forward Diff. |     47.18 |     2.077 |    0.1996 |    0.2200 |
-#> |.....................|    0.1318 |    -41.07 |    -9.197 |     3.259 |
-#> |.....................|    -1.748 |    0.9101 |     6.743 |    -9.229 |
-#> |.....................|    -7.511 |    -7.855 |...........|...........|
-#> |   22|     480.07574 |    0.9930 |    -1.014 |   -0.9117 |   -0.8956 |
-#> |.....................|   -0.8455 |   -0.5517 |   -0.8106 |   -0.8919 |
-#> |.....................|   -0.8795 |   -0.8825 |   -0.9247 |   -0.8007 |
-#> |.....................|   -0.8161 |   -0.8129 |...........|...........|
-#> |    U|     480.07574 |     92.35 |    -5.314 |   -0.9404 |   -0.1112 |
-#> |.....................|     2.300 |     1.390 |   0.03121 |     1.186 |
-#> |.....................|   0.03018 |    0.7555 |    0.8317 |     1.295 |
-#> |.....................|     1.126 |     1.133 |...........|...........|
-#> |    X|     480.07574 |     92.35 |  0.004921 |    0.2808 |    0.8947 |
-#> |.....................|     9.973 |     1.390 |   0.03121 |     1.186 |
-#> |.....................|   0.03018 |    0.7555 |    0.8317 |     1.295 |
-#> |.....................|     1.126 |     1.133 |...........|...........|
-#> |    F| Forward Diff. |    -48.22 |     1.995 |  -0.04658 |    0.1415 |
-#> |.....................|   -0.1316 |    -39.56 |    -9.522 |     3.639 |
-#> |.....................|    -1.878 |    0.6154 |     4.556 |    -8.937 |
-#> |.....................|    -7.320 |    -7.563 |...........|...........|
-#> |   23|     479.25211 |     1.000 |    -1.015 |   -0.9118 |   -0.8957 |
-#> |.....................|   -0.8454 |   -0.5343 |   -0.8082 |   -0.8940 |
-#> |.....................|   -0.8781 |   -0.8826 |   -0.9261 |   -0.7958 |
-#> |.....................|   -0.8122 |   -0.8090 |...........|...........|
-#> |    U|     479.25211 |     93.02 |    -5.315 |   -0.9405 |   -0.1113 |
-#> |.....................|     2.300 |     1.400 |   0.03125 |     1.184 |
-#> |.....................|   0.03020 |    0.7553 |    0.8305 |     1.301 |
-#> |.....................|     1.130 |     1.137 |...........|...........|
-#> |    X|     479.25211 |     93.02 |  0.004915 |    0.2808 |    0.8946 |
-#> |.....................|     9.974 |     1.400 |   0.03125 |     1.184 |
-#> |.....................|   0.03020 |    0.7553 |    0.8305 |     1.301 |
-#> |.....................|     1.130 |     1.137 |...........|...........|
-#> |    F| Forward Diff. |     48.39 |     2.048 |    0.2189 |    0.2175 |
-#> |.....................|    0.1393 |    -38.80 |    -8.286 |     3.169 |
-#> |.....................|    -1.757 |    0.9021 |     6.456 |    -8.802 |
-#> |.....................|    -7.165 |    -7.452 |...........|...........|
-#> |   24|     478.42395 |    0.9935 |    -1.017 |   -0.9119 |   -0.8959 |
-#> |.....................|   -0.8454 |   -0.5169 |   -0.8064 |   -0.8963 |
-#> |.....................|   -0.8766 |   -0.8829 |   -0.9277 |   -0.7908 |
-#> |.....................|   -0.8081 |   -0.8051 |...........|...........|
-#> |    U|     478.42395 |     92.40 |    -5.317 |   -0.9406 |   -0.1115 |
-#> |.....................|     2.300 |     1.411 |   0.03128 |     1.183 |
-#> |.....................|   0.03022 |    0.7552 |    0.8290 |     1.307 |
-#> |.....................|     1.134 |     1.141 |...........|...........|
-#> |    X|     478.42395 |     92.40 |  0.004909 |    0.2808 |    0.8945 |
-#> |.....................|     9.974 |     1.411 |   0.03128 |     1.183 |
-#> |.....................|   0.03022 |    0.7552 |    0.8290 |     1.307 |
-#> |.....................|     1.134 |     1.141 |...........|...........|
-#> |    F| Forward Diff. |    -41.65 |     1.977 |  -0.02866 |    0.1453 |
-#> |.....................|   -0.1180 |    -37.67 |    -8.677 |     3.579 |
-#> |.....................|    -1.774 |    0.6894 |     5.855 |    -8.506 |
-#> |.....................|    -6.962 |    -7.153 |...........|...........|
-#> |   25|     477.65816 |     1.000 |    -1.018 |   -0.9120 |   -0.8960 |
-#> |.....................|   -0.8454 |   -0.4997 |   -0.8051 |   -0.8988 |
-#> |.....................|   -0.8750 |   -0.8832 |   -0.9313 |   -0.7859 |
-#> |.....................|   -0.8042 |   -0.8013 |...........|...........|
-#> |    U|     477.65816 |     93.02 |    -5.318 |   -0.9406 |   -0.1116 |
-#> |.....................|     2.300 |     1.421 |   0.03130 |     1.181 |
-#> |.....................|   0.03025 |    0.7549 |    0.8259 |     1.313 |
-#> |.....................|     1.138 |     1.145 |...........|...........|
-#> |    X|     477.65816 |     93.02 |  0.004901 |    0.2808 |    0.8944 |
-#> |.....................|     9.974 |     1.421 |   0.03130 |     1.181 |
-#> |.....................|   0.03025 |    0.7549 |    0.8259 |     1.313 |
-#> |.....................|     1.138 |     1.145 |...........|...........|
-#> |    F| Forward Diff. |     47.50 |     2.013 |    0.2278 |    0.2145 |
-#> |.....................|    0.1415 |    -36.68 |    -7.460 |     3.039 |
-#> |.....................|    -1.807 |    0.8669 |     6.124 |    -8.373 |
-#> |.....................|    -6.814 |    -7.074 |...........|...........|
-#> |   26|     476.87668 |    0.9936 |    -1.020 |   -0.9121 |   -0.8962 |
-#> |.....................|   -0.8454 |   -0.4825 |   -0.8047 |   -0.9014 |
-#> |.....................|   -0.8732 |   -0.8836 |   -0.9351 |   -0.7808 |
-#> |.....................|   -0.8001 |   -0.7975 |...........|...........|
-#> |    U|     476.87668 |     92.41 |    -5.320 |   -0.9408 |   -0.1117 |
-#> |.....................|     2.300 |     1.431 |   0.03130 |     1.180 |
-#> |.....................|   0.03028 |    0.7546 |    0.8226 |     1.319 |
-#> |.....................|     1.143 |     1.149 |...........|...........|
-#> |    X|     476.87668 |     92.41 |  0.004893 |    0.2807 |    0.8943 |
-#> |.....................|     9.974 |     1.431 |   0.03130 |     1.180 |
-#> |.....................|   0.03028 |    0.7546 |    0.8226 |     1.319 |
-#> |.....................|     1.143 |     1.149 |...........|...........|
-#> |    F| Forward Diff. |    -40.64 |     1.935 |  -0.02164 |    0.1511 |
-#> |.....................|   -0.1127 |    -35.59 |    -7.858 |     3.450 |
-#> |.....................|    -1.805 |    0.6731 |     3.945 |    -8.048 |
-#> |.....................|    -6.589 |    -6.756 |...........|...........|
-#> |   27|     476.16299 |     1.000 |    -1.022 |   -0.9123 |   -0.8963 |
-#> |.....................|   -0.8454 |   -0.4651 |   -0.8047 |   -0.9041 |
-#> |.....................|   -0.8711 |   -0.8840 |   -0.9355 |   -0.7757 |
-#> |.....................|   -0.7959 |   -0.7936 |...........|...........|
-#> |    U|     476.16299 |     93.01 |    -5.322 |   -0.9409 |   -0.1119 |
-#> |.....................|     2.300 |     1.442 |   0.03130 |     1.178 |
-#> |.....................|   0.03031 |    0.7543 |    0.8222 |     1.326 |
-#> |.....................|     1.147 |     1.153 |...........|...........|
-#> |    X|     476.16299 |     93.01 |  0.004885 |    0.2807 |    0.8941 |
-#> |.....................|     9.974 |     1.442 |   0.03130 |     1.178 |
-#> |.....................|   0.03031 |    0.7543 |    0.8222 |     1.326 |
-#> |.....................|     1.147 |     1.153 |...........|...........|
-#> |    F| Forward Diff. |     44.38 |     1.982 |    0.2331 |    0.2213 |
-#> |.....................|    0.1467 |    -34.64 |    -6.709 |     2.894 |
-#> |.....................|    -1.888 |    0.7760 |     4.358 |    -7.901 |
-#> |.....................|    -6.419 |    -6.620 |...........|...........|
-#> |   28|     475.47434 |    0.9938 |    -1.024 |   -0.9125 |   -0.8966 |
-#> |.....................|   -0.8454 |   -0.4477 |   -0.8058 |   -0.9069 |
-#> |.....................|   -0.8685 |   -0.8844 |   -0.9328 |   -0.7706 |
-#> |.....................|   -0.7919 |   -0.7898 |...........|...........|
-#> |    U|     475.47434 |     92.43 |    -5.324 |   -0.9411 |   -0.1122 |
-#> |.....................|     2.300 |     1.452 |   0.03129 |     1.177 |
-#> |.....................|   0.03035 |    0.7540 |    0.8246 |     1.332 |
-#> |.....................|     1.151 |     1.157 |...........|...........|
-#> |    X|     475.47434 |     92.43 |  0.004875 |    0.2807 |    0.8939 |
-#> |.....................|     9.974 |     1.452 |   0.03129 |     1.177 |
-#> |.....................|   0.03035 |    0.7540 |    0.8246 |     1.332 |
-#> |.....................|     1.151 |     1.157 |...........|...........|
-#> |    F| Forward Diff. |    -38.01 |     1.932 |  -0.02542 |    0.1483 |
-#> |.....................|   -0.1147 |    -33.71 |    -7.114 |     3.216 |
-#> |.....................|    -1.879 |    0.6267 |     4.067 |    -7.573 |
-#> |.....................|    -6.213 |    -6.338 |...........|...........|
-#> |   29|     474.82575 |    0.9998 |    -1.026 |   -0.9126 |   -0.8968 |
-#> |.....................|   -0.8454 |   -0.4303 |   -0.8075 |   -0.9096 |
-#> |.....................|   -0.8656 |   -0.8846 |   -0.9310 |   -0.7657 |
-#> |.....................|   -0.7878 |   -0.7862 |...........|...........|
-#> |    U|     474.82575 |     92.98 |    -5.326 |   -0.9413 |   -0.1124 |
-#> |.....................|     2.300 |     1.462 |   0.03126 |     1.175 |
-#> |.....................|   0.03039 |    0.7538 |    0.8261 |     1.338 |
-#> |.....................|     1.156 |     1.161 |...........|...........|
-#> |    X|     474.82575 |     92.98 |  0.004864 |    0.2806 |    0.8937 |
-#> |.....................|     9.974 |     1.462 |   0.03126 |     1.175 |
-#> |.....................|   0.03039 |    0.7538 |    0.8261 |     1.338 |
-#> |.....................|     1.156 |     1.161 |...........|...........|
-#> |    F| Forward Diff. |     40.83 |     1.980 |    0.2123 |    0.2125 |
-#> |.....................|    0.1324 |    -32.65 |    -6.032 |     2.979 |
-#> |.....................|    -1.922 |    0.7692 |     4.596 |    -7.426 |
-#> |.....................|    -6.058 |    -6.217 |...........|...........|
-#> |   30|     474.18202 |    0.9939 |    -1.028 |   -0.9128 |   -0.8971 |
-#> |.....................|   -0.8454 |   -0.4131 |   -0.8106 |   -0.9130 |
-#> |.....................|   -0.8620 |   -0.8851 |   -0.9307 |   -0.7608 |
-#> |.....................|   -0.7838 |   -0.7828 |...........|...........|
-#> |    U|     474.18202 |     92.44 |    -5.328 |   -0.9414 |   -0.1127 |
-#> |.....................|     2.300 |     1.473 |   0.03121 |     1.173 |
-#> |.....................|   0.03044 |    0.7535 |    0.8264 |     1.344 |
-#> |.....................|     1.160 |     1.165 |...........|...........|
-#> |    X|     474.18202 |     92.44 |  0.004852 |    0.2806 |    0.8935 |
-#> |.....................|     9.974 |     1.473 |   0.03121 |     1.173 |
-#> |.....................|   0.03044 |    0.7535 |    0.8264 |     1.344 |
-#> |.....................|     1.160 |     1.165 |...........|...........|
-#> |    F| Forward Diff. |    -37.33 |     1.920 |  -0.03157 |    0.1462 |
-#> |.....................|   -0.1145 |    -31.92 |    -6.433 |     3.018 |
-#> |.....................|    -1.919 |    0.6114 |     5.640 |    -7.155 |
-#> |.....................|    -5.876 |    -5.958 |...........|...........|
-#> |   31|     473.55376 |    0.9995 |    -1.031 |   -0.9130 |   -0.8973 |
-#> |.....................|   -0.8454 |   -0.3971 |   -0.8148 |   -0.9162 |
-#> |.....................|   -0.8581 |   -0.8855 |   -0.9368 |   -0.7563 |
-#> |.....................|   -0.7800 |   -0.7797 |...........|...........|
-#> |    U|     473.55376 |     92.95 |    -5.331 |   -0.9416 |   -0.1129 |
-#> |.....................|     2.300 |     1.482 |   0.03115 |     1.171 |
-#> |.....................|   0.03050 |    0.7531 |    0.8211 |     1.349 |
-#> |.....................|     1.164 |     1.168 |...........|...........|
-#> |    X|     473.55376 |     92.95 |  0.004838 |    0.2806 |    0.8932 |
-#> |.....................|     9.974 |     1.482 |   0.03115 |     1.171 |
-#> |.....................|   0.03050 |    0.7531 |    0.8211 |     1.349 |
-#> |.....................|     1.164 |     1.168 |...........|...........|
-#> |   32|     472.90182 |    0.9995 |    -1.035 |   -0.9132 |   -0.8977 |
-#> |.....................|   -0.8453 |   -0.3799 |   -0.8225 |   -0.9204 |
-#> |.....................|   -0.8527 |   -0.8861 |   -0.9447 |   -0.7510 |
-#> |.....................|   -0.7757 |   -0.7763 |...........|...........|
-#> |    U|     472.90182 |     92.96 |    -5.335 |   -0.9418 |   -0.1133 |
-#> |.....................|     2.300 |     1.493 |   0.03104 |     1.168 |
-#> |.....................|   0.03058 |    0.7527 |    0.8141 |     1.356 |
-#> |.....................|     1.169 |     1.172 |...........|...........|
-#> |    X|     472.90182 |     92.96 |  0.004819 |    0.2805 |    0.8929 |
-#> |.....................|     9.975 |     1.493 |   0.03104 |     1.168 |
-#> |.....................|   0.03058 |    0.7527 |    0.8141 |     1.356 |
-#> |.....................|     1.169 |     1.172 |...........|...........|
-#> |   33|     469.90339 |    0.9997 |    -1.054 |   -0.9142 |   -0.8996 |
-#> |.....................|   -0.8452 |   -0.2944 |   -0.8611 |   -0.9412 |
-#> |.....................|   -0.8255 |   -0.8889 |   -0.9843 |   -0.7249 |
-#> |.....................|   -0.7539 |   -0.7597 |...........|...........|
-#> |    U|     469.90339 |     92.98 |    -5.354 |   -0.9427 |   -0.1152 |
-#> |.....................|     2.300 |     1.544 |   0.03046 |     1.156 |
-#> |.....................|   0.03099 |    0.7505 |    0.7794 |     1.387 |
-#> |.....................|     1.192 |     1.190 |...........|...........|
-#> |    X|     469.90339 |     92.98 |  0.004727 |    0.2803 |    0.8912 |
-#> |.....................|     9.976 |     1.544 |   0.03046 |     1.156 |
-#> |.....................|   0.03099 |    0.7505 |    0.7794 |     1.387 |
-#> |.....................|     1.192 |     1.190 |...........|...........|
-#> |   34|     461.71523 |     1.001 |    -1.134 |   -0.9184 |   -0.9072 |
-#> |.....................|   -0.8447 |   0.05742 |    -1.020 |    -1.027 |
-#> |.....................|   -0.7136 |   -0.9005 |    -1.147 |   -0.6175 |
-#> |.....................|   -0.6642 |   -0.6913 |...........|...........|
-#> |    U|     461.71523 |     93.05 |    -5.434 |   -0.9467 |   -0.1228 |
-#> |.....................|     2.301 |     1.755 |   0.02808 |     1.105 |
-#> |.....................|   0.03267 |    0.7417 |    0.6368 |     1.518 |
-#> |.....................|     1.288 |     1.263 |...........|...........|
-#> |    X|     461.71523 |     93.05 |  0.004366 |    0.2795 |    0.8844 |
-#> |.....................|     9.981 |     1.755 |   0.02808 |     1.105 |
-#> |.....................|   0.03267 |    0.7417 |    0.6368 |     1.518 |
-#> |.....................|     1.288 |     1.263 |...........|...........|
-#> |    F| Forward Diff. |     11.20 |     1.045 |     1.020 |    0.3495 |
-#> |.....................|    0.7923 |    -15.00 |   -0.3969 |    -1.315 |
-#> |.....................|    -3.031 |    0.2676 |    -6.780 |    -1.078 |
-#> |.....................|  -0.09081 |    -1.463 |...........|...........|
-#> |   35|     459.94653 |     1.009 |    -1.206 |   -0.9768 |   -0.9283 |
-#> |.....................|   -0.8884 |    0.4547 |    -1.238 |   -0.9419 |
-#> |.....................|   -0.5030 |   -0.9080 |   -0.7892 |   -0.6450 |
-#> |.....................|   -0.7313 |   -0.6959 |...........|...........|
-#> |    U|     459.94653 |     93.85 |    -5.506 |    -1.002 |   -0.1439 |
-#> |.....................|     2.257 |     1.993 |   0.02480 |     1.155 |
-#> |.....................|   0.03583 |    0.7361 |    0.9504 |     1.484 |
-#> |.....................|     1.216 |     1.258 |...........|...........|
-#> |    X|     459.94653 |     93.85 |  0.004064 |    0.2686 |    0.8660 |
-#> |.....................|     9.554 |     1.993 |   0.02480 |     1.155 |
-#> |.....................|   0.03583 |    0.7361 |    0.9504 |     1.484 |
-#> |.....................|     1.216 |     1.258 |...........|...........|
-#> |    F| Forward Diff. |     117.0 |     1.389 |    -1.721 |   -0.1200 |
-#> |.....................|  0.004314 |    -5.763 |     2.093 |     3.426 |
-#> |.....................|    -1.378 |     2.600 |     15.14 |    -1.236 |
-#> |.....................|    -4.018 |    -1.529 |...........|...........|
-#> |   36|     458.11528 |     1.003 |    -1.307 |   -0.9477 |   -0.9422 |
-#> |.....................|   -0.9430 |    0.6906 |    -1.630 |   -0.8850 |
-#> |.....................|   -0.1864 |    -1.043 |   -0.8947 |   -0.8359 |
-#> |.....................|   -0.7822 |   -0.7759 |...........|...........|
-#> |    U|     458.11528 |     93.30 |    -5.607 |   -0.9742 |   -0.1578 |
-#> |.....................|     2.202 |     2.135 |   0.01893 |     1.190 |
-#> |.....................|   0.04058 |    0.6334 |    0.8579 |     1.253 |
-#> |.....................|     1.162 |     1.172 |...........|...........|
-#> |    X|     458.11528 |     93.30 |  0.003671 |    0.2740 |    0.8540 |
-#> |.....................|     9.046 |     2.135 |   0.01893 |     1.190 |
-#> |.....................|   0.04058 |    0.6334 |    0.8579 |     1.253 |
-#> |.....................|     1.162 |     1.172 |...........|...........|
-#> |    F| Forward Diff. |    -4.502 |    0.8367 |   -0.1865 |   -0.1361 |
-#> |.....................|   -0.6555 |    -2.945 |     1.425 |     8.523 |
-#> |.....................|   -0.6882 |    -2.700 |     7.982 |    -9.961 |
-#> |.....................|    -6.514 |    -5.474 |...........|...........|
-#> |   37|     454.42202 |     1.008 |    -1.411 |   -0.9501 |   -0.9563 |
-#> |.....................|   -0.9900 |    0.8215 |    -2.099 |    -1.032 |
-#> |.....................|    0.1520 |    -1.049 |   -0.9274 |   -0.7533 |
-#> |.....................|   -0.7158 |   -0.7241 |...........|...........|
-#> |    U|     454.42202 |     93.74 |    -5.711 |   -0.9765 |   -0.1719 |
-#> |.....................|     2.155 |     2.214 |   0.01188 |     1.102 |
-#> |.....................|   0.04565 |    0.6287 |    0.8293 |     1.353 |
-#> |.....................|     1.233 |     1.228 |...........|...........|
-#> |    X|     454.42202 |     93.74 |  0.003311 |    0.2736 |    0.8421 |
-#> |.....................|     8.631 |     2.214 |   0.01188 |     1.102 |
-#> |.....................|   0.04565 |    0.6287 |    0.8293 |     1.353 |
-#> |.....................|     1.233 |     1.228 |...........|...........|
-#> |   38|     451.48622 |     1.000 |    -1.659 |   -0.9551 |   -0.9914 |
-#> |.....................|    -1.111 |     1.029 |    -2.892 |    -1.353 |
-#> |.....................|    0.9897 |    -1.076 |   -0.9627 |   -0.6147 |
-#> |.....................|   -0.5957 |   -0.6379 |...........|...........|
-#> |    U|     451.48622 |     93.01 |    -5.959 |   -0.9812 |   -0.2070 |
-#> |.....................|     2.035 |     2.338 | 5.960e-07 |    0.9088 |
-#> |.....................|   0.05822 |    0.6083 |    0.7984 |     1.521 |
-#> |.....................|     1.361 |     1.320 |...........|...........|
-#> |    X|     451.48622 |     93.01 |  0.002583 |    0.2727 |    0.8130 |
-#> |.....................|     7.651 |     2.338 | 5.960e-07 |    0.9088 |
-#> |.....................|   0.05822 |    0.6083 |    0.7984 |     1.521 |
-#> |.....................|     1.361 |     1.320 |...........|...........|
-#> |    F| Forward Diff. |    -68.34 |   0.03355 |   0.09905 |    -1.306 |
-#> |.....................|    -5.058 |    -1.204 |  -0.09883 |    -1.076 |
-#> |.....................|    -2.726 |    -4.145 |     7.646 |   -0.5743 |
-#> |.....................|     2.003 |     2.613 |...........|...........|
-#> |   39|     453.25472 |     1.003 |    -2.027 |    -1.069 |   -0.8933 |
-#> |.....................|   -0.6960 |     1.084 |    -2.892 |    -1.695 |
-#> |.....................|     2.689 |   -0.4882 |    -1.206 |   -0.2814 |
-#> |.....................|   -0.7545 |   -0.8496 |...........|...........|
-#> |    U|     453.25472 |     93.31 |    -6.327 |    -1.089 |   -0.1089 |
-#> |.....................|     2.449 |     2.371 | 5.960e-07 |    0.7037 |
-#> |.....................|   0.08370 |     1.055 |    0.5857 |     1.926 |
-#> |.....................|     1.191 |     1.093 |...........|...........|
-#> |    X|     453.25472 |     93.31 |  0.001787 |    0.2519 |    0.8968 |
-#> |.....................|     11.58 |     2.371 | 5.960e-07 |    0.7037 |
-#> |.....................|   0.08370 |     1.055 |    0.5857 |     1.926 |
-#> |.....................|     1.191 |     1.093 |...........|...........|
-#> |   40|     449.59369 |     1.000 |    -1.818 |    -1.010 |   -0.9508 |
-#> |.....................|   -0.9364 |     1.052 |    -2.892 |    -1.498 |
-#> |.....................|     1.730 |   -0.8175 |    -1.073 |   -0.4671 |
-#> |.....................|   -0.6691 |   -0.7270 |...........|...........|
-#> |    U|     449.59369 |     93.04 |    -6.118 |    -1.033 |   -0.1664 |
-#> |.....................|     2.209 |     2.352 | 5.960e-07 |    0.8216 |
-#> |.....................|   0.06933 |    0.8048 |    0.7021 |     1.700 |
-#> |.....................|     1.282 |     1.225 |...........|...........|
-#> |    X|     449.59369 |     93.04 |  0.002202 |    0.2625 |    0.8467 |
-#> |.....................|     9.106 |     2.352 | 5.960e-07 |    0.8216 |
-#> |.....................|   0.06933 |    0.8048 |    0.7021 |     1.700 |
-#> |.....................|     1.282 |     1.225 |...........|...........|
-#> |    F| Forward Diff. |    -128.1 |    0.1096 |    -3.510 |   -0.1773 |
-#> |.....................|   -0.1823 |    -1.358 | -0.002263 |     1.313 |
-#> |.....................|    -1.294 |     5.530 |     5.100 |     4.831 |
-#> |.....................|    -1.292 |    -3.851 |...........|...........|
-#> |   41|     472.13387 |     1.020 |    -1.985 |   -0.7592 |   -0.7822 |
-#> |.....................|   -0.2976 |     1.062 |    -2.892 |    -1.866 |
-#> |.....................|     3.141 |   -0.7519 |    -1.136 |   -0.6405 |
-#> |.....................|   -0.7706 |   -0.2153 |...........|...........|
-#> |    U|     472.13387 |     94.83 |    -6.285 |   -0.7970 |  0.002176 |
-#> |.....................|     2.848 |     2.358 | 5.960e-07 |    0.6009 |
-#> |.....................|   0.09049 |    0.8547 |    0.6467 |     1.490 |
-#> |.....................|     1.174 |     1.773 |...........|...........|
-#> |    X|     472.13387 |     94.83 |  0.001864 |    0.3107 |     1.002 |
-#> |.....................|     17.25 |     2.358 | 5.960e-07 |    0.6009 |
-#> |.....................|   0.09049 |    0.8547 |    0.6467 |     1.490 |
-#> |.....................|     1.174 |     1.773 |...........|...........|
-#> |   42|     454.13083 |     1.030 |    -1.841 |   -0.9756 |   -0.9280 |
-#> |.....................|   -0.8501 |     1.054 |    -2.892 |    -1.548 |
-#> |.....................|     1.921 |   -0.8098 |    -1.082 |   -0.4916 |
-#> |.....................|   -0.6825 |   -0.6571 |...........|...........|
-#> |    U|     454.13083 |     95.82 |    -6.141 |    -1.000 |   -0.1436 |
-#> |.....................|     2.295 |     2.353 | 5.960e-07 |    0.7917 |
-#> |.....................|   0.07219 |    0.8106 |    0.6936 |     1.671 |
-#> |.....................|     1.268 |     1.299 |...........|...........|
-#> |    X|     454.13083 |     95.82 |  0.002153 |    0.2688 |    0.8663 |
-#> |.....................|     9.927 |     2.353 | 5.960e-07 |    0.7917 |
-#> |.....................|   0.07219 |    0.8106 |    0.6936 |     1.671 |
-#> |.....................|     1.268 |     1.299 |...........|...........|
-#> |   43|     454.81886 |     1.032 |    -1.823 |    -1.002 |   -0.9459 |
-#> |.....................|   -0.9179 |     1.053 |    -2.892 |    -1.509 |
-#> |.....................|     1.771 |   -0.8169 |    -1.076 |   -0.4733 |
-#> |.....................|   -0.6717 |   -0.7113 |...........|...........|
-#> |    U|     454.81886 |     95.94 |    -6.123 |    -1.025 |   -0.1614 |
-#> |.....................|     2.227 |     2.352 | 5.960e-07 |    0.8150 |
-#> |.....................|   0.06994 |    0.8052 |    0.6994 |     1.693 |
-#> |.....................|     1.280 |     1.241 |...........|...........|
-#> |    X|     454.81886 |     95.94 |  0.002192 |    0.2640 |    0.8509 |
-#> |.....................|     9.277 |     2.352 | 5.960e-07 |    0.8150 |
-#> |.....................|   0.06994 |    0.8052 |    0.6994 |     1.693 |
-#> |.....................|     1.280 |     1.241 |...........|...........|
-#> |   44|     449.57011 |     1.014 |    -1.818 |    -1.010 |   -0.9508 |
-#> |.....................|   -0.9364 |     1.053 |    -2.892 |    -1.499 |
-#> |.....................|     1.730 |   -0.8181 |    -1.073 |   -0.4676 |
-#> |.....................|   -0.6690 |   -0.7267 |...........|...........|
-#> |    U|     449.57011 |     94.27 |    -6.118 |    -1.033 |   -0.1664 |
-#> |.....................|     2.209 |     2.352 | 5.995e-07 |    0.8215 |
-#> |.....................|   0.06933 |    0.8044 |    0.7016 |     1.700 |
-#> |.....................|     1.283 |     1.225 |...........|...........|
-#> |    X|     449.57011 |     94.27 |  0.002202 |    0.2626 |    0.8467 |
-#> |.....................|     9.106 |     2.352 | 5.995e-07 |    0.8215 |
-#> |.....................|   0.06933 |    0.8044 |    0.7016 |     1.700 |
-#> |.....................|     1.283 |     1.225 |...........|...........|
-#> |    F| Forward Diff. |     126.9 |    0.1582 |    -2.201 |   0.05331 |
-#> |.....................|    0.4695 |   -0.6265 |   0.01503 |    0.4241 |
-#> |.....................|    -1.337 |     5.854 |     6.688 |     4.536 |
-#> |.....................|    -1.410 |    -4.016 |...........|...........|
-#> |   45|     449.14922 |     1.007 |    -1.818 |    -1.010 |   -0.9508 |
-#> |.....................|   -0.9364 |     1.053 |    -2.892 |    -1.499 |
-#> |.....................|     1.730 |   -0.8183 |    -1.074 |   -0.4678 |
-#> |.....................|   -0.6689 |   -0.7265 |...........|...........|
-#> |    U|     449.14922 |     93.66 |    -6.118 |    -1.033 |   -0.1664 |
-#> |.....................|     2.209 |     2.352 | 5.960e-07 |    0.8215 |
-#> |.....................|   0.06933 |    0.8042 |    0.7014 |     1.699 |
-#> |.....................|     1.283 |     1.225 |...........|...........|
-#> |    X|     449.14922 |     93.66 |  0.002202 |    0.2626 |    0.8467 |
-#> |.....................|     9.106 |     2.352 | 5.960e-07 |    0.8215 |
-#> |.....................|   0.06933 |    0.8042 |    0.7014 |     1.699 |
-#> |.....................|     1.283 |     1.225 |...........|...........|
-#> |    F| Forward Diff. |   -0.4066 |    0.1367 |    -2.828 |  -0.06013 |
-#> |.....................|    0.1445 |   -0.8286 |   0.01677 |    0.9213 |
-#> |.....................|    -1.224 |     4.943 |     4.017 |     5.223 |
-#> |.....................|    -1.311 |    -3.922 |...........|...........|
-#> |   46|     449.08136 |     1.007 |    -1.818 |    -1.008 |   -0.9507 |
-#> |.....................|   -0.9365 |     1.053 |    -2.892 |    -1.499 |
-#> |.....................|     1.731 |   -0.8217 |    -1.076 |   -0.4714 |
-#> |.....................|   -0.6680 |   -0.7238 |...........|...........|
-#> |    U|     449.08136 |     93.68 |    -6.118 |    -1.031 |   -0.1663 |
-#> |.....................|     2.209 |     2.353 | 5.960e-07 |    0.8212 |
-#> |.....................|   0.06934 |    0.8016 |    0.6990 |     1.695 |
-#> |.....................|     1.284 |     1.228 |...........|...........|
-#> |    X|     449.08136 |     93.68 |  0.002202 |    0.2629 |    0.8468 |
-#> |.....................|     9.105 |     2.353 | 5.960e-07 |    0.8212 |
-#> |.....................|   0.06934 |    0.8016 |    0.6990 |     1.695 |
-#> |.....................|     1.284 |     1.228 |...........|...........|
-#> |   47|     448.89872 |     1.008 |    -1.819 |    -1.002 |   -0.9506 |
-#> |.....................|   -0.9368 |     1.055 |    -2.892 |    -1.501 |
-#> |.....................|     1.734 |   -0.8317 |    -1.084 |   -0.4820 |
-#> |.....................|   -0.6654 |   -0.7159 |...........|...........|
-#> |    U|     448.89872 |     93.76 |    -6.119 |    -1.025 |   -0.1662 |
-#> |.....................|     2.209 |     2.354 | 5.960e-07 |    0.8200 |
-#> |.....................|   0.06938 |    0.7940 |    0.6918 |     1.682 |
-#> |.....................|     1.286 |     1.237 |...........|...........|
-#> |    X|     448.89872 |     93.76 |  0.002202 |    0.2640 |    0.8469 |
-#> |.....................|     9.102 |     2.354 | 5.960e-07 |    0.8200 |
-#> |.....................|   0.06938 |    0.7940 |    0.6918 |     1.682 |
-#> |.....................|     1.286 |     1.237 |...........|...........|
-#> |   48|     448.46351 |     1.011 |    -1.820 |   -0.9792 |   -0.9501 |
-#> |.....................|   -0.9380 |     1.062 |    -2.892 |    -1.509 |
-#> |.....................|     1.744 |   -0.8718 |    -1.117 |   -0.5244 |
-#> |.....................|   -0.6547 |   -0.6840 |...........|...........|
-#> |    U|     448.46351 |     94.07 |    -6.120 |    -1.004 |   -0.1657 |
-#> |.....................|     2.207 |     2.358 | 5.960e-07 |    0.8155 |
-#> |.....................|   0.06953 |    0.7635 |    0.6633 |     1.631 |
-#> |.....................|     1.298 |     1.271 |...........|...........|
-#> |    X|     448.46351 |     94.07 |  0.002199 |    0.2682 |    0.8473 |
-#> |.....................|     9.092 |     2.358 | 5.960e-07 |    0.8155 |
-#> |.....................|   0.06953 |    0.7635 |    0.6633 |     1.631 |
-#> |.....................|     1.298 |     1.271 |...........|...........|
-#> |    F| Forward Diff. |     75.37 |    0.2597 |   -0.1569 |   0.03608 |
-#> |.....................|    0.3501 |   -0.3601 |  -0.01324 |    0.5025 |
-#> |.....................|    -1.327 |     4.308 |    0.9122 |     2.456 |
-#> |.....................|   -0.5631 |    -1.887 |...........|...........|
-#> |   49|     448.12149 |     1.008 |    -1.833 |   -0.9950 |   -0.9378 |
-#> |.....................|   -0.8937 |     1.062 |    -2.892 |    -1.543 |
-#> |.....................|     1.827 |   -0.8899 |    -1.115 |   -0.5324 |
-#> |.....................|   -0.6574 |   -0.6703 |...........|...........|
-#> |    U|     448.12149 |     93.73 |    -6.133 |    -1.019 |   -0.1534 |
-#> |.....................|     2.252 |     2.358 | 5.960e-07 |    0.7948 |
-#> |.....................|   0.07077 |    0.7498 |    0.6653 |     1.621 |
-#> |.....................|     1.295 |     1.285 |...........|...........|
-#> |    X|     448.12149 |     93.73 |  0.002169 |    0.2653 |    0.8578 |
-#> |.....................|     9.504 |     2.358 | 5.960e-07 |    0.7948 |
-#> |.....................|   0.07077 |    0.7498 |    0.6653 |     1.621 |
-#> |.....................|     1.295 |     1.285 |...........|...........|
-#> |    F| Forward Diff. |     13.78 |    0.2222 |    -1.381 |    0.2569 |
-#> |.....................|     1.259 |   -0.5740 |  -0.02850 |    0.1620 |
-#> |.....................|    -1.241 |     3.503 |    0.9893 |     2.205 |
-#> |.....................|   -0.7124 |    -1.054 |...........|...........|
-#> |   50|     447.94443 |     1.007 |    -1.844 |   -0.9902 |   -0.9390 |
-#> |.....................|   -0.9059 |     1.062 |    -2.881 |    -1.561 |
-#> |.....................|     1.911 |   -0.9357 |    -1.119 |   -0.5167 |
-#> |.....................|   -0.6474 |   -0.7008 |...........|...........|
-#> |    U|     447.94443 |     93.62 |    -6.144 |    -1.014 |   -0.1546 |
-#> |.....................|     2.239 |     2.358 | 0.0001615 |    0.7838 |
-#> |.....................|   0.07204 |    0.7150 |    0.6617 |     1.640 |
-#> |.....................|     1.306 |     1.253 |...........|...........|
-#> |    X|     447.94443 |     93.62 |  0.002146 |    0.2662 |    0.8567 |
-#> |.....................|     9.388 |     2.358 | 0.0001615 |    0.7838 |
-#> |.....................|   0.07204 |    0.7150 |    0.6617 |     1.640 |
-#> |.....................|     1.306 |     1.253 |...........|...........|
-#> |    F| Forward Diff. |    -5.879 |    0.2071 |    -1.215 |    0.2527 |
-#> |.....................|    0.8228 |   -0.5096 |  -0.06036 |    0.4983 |
-#> |.....................|    -1.183 |     1.766 |     2.266 |     2.617 |
-#> |.....................|   -0.3179 |    -2.389 |...........|...........|
-#> |   51|     447.77390 |     1.007 |    -1.858 |    -1.003 |   -0.9470 |
-#> |.....................|   -0.9285 |     1.056 |    -2.855 |    -1.583 |
-#> |.....................|     2.006 |   -0.9406 |    -1.128 |   -0.5198 |
-#> |.....................|   -0.6539 |   -0.6964 |...........|...........|
-#> |    U|      447.7739 |     93.69 |    -6.158 |    -1.026 |   -0.1626 |
-#> |.....................|     2.217 |     2.354 | 0.0005494 |    0.7710 |
-#> |.....................|   0.07347 |    0.7113 |    0.6533 |     1.636 |
-#> |.....................|     1.299 |     1.257 |...........|...........|
-#> |    X|      447.7739 |     93.69 |  0.002117 |    0.2639 |    0.8500 |
-#> |.....................|     9.179 |     2.354 | 0.0005494 |    0.7710 |
-#> |.....................|   0.07347 |    0.7113 |    0.6533 |     1.636 |
-#> |.....................|     1.299 |     1.257 |...........|...........|
-#> |   52|     447.56301 |     1.006 |    -1.897 |    -1.041 |   -0.9708 |
-#> |.....................|   -0.9958 |     1.039 |    -2.777 |    -1.647 |
-#> |.....................|     2.291 |   -0.9540 |    -1.156 |   -0.5273 |
-#> |.....................|   -0.6737 |   -0.6848 |...........|...........|
-#> |    U|     447.56301 |     93.51 |    -6.197 |    -1.061 |   -0.1864 |
-#> |.....................|     2.150 |     2.344 |  0.001717 |    0.7326 |
-#> |.....................|   0.07774 |    0.7011 |    0.6293 |     1.627 |
-#> |.....................|     1.278 |     1.270 |...........|...........|
-#> |    X|     447.56301 |     93.51 |  0.002035 |    0.2570 |    0.8300 |
-#> |.....................|     8.581 |     2.344 |  0.001717 |    0.7326 |
-#> |.....................|   0.07774 |    0.7011 |    0.6293 |     1.627 |
-#> |.....................|     1.278 |     1.270 |...........|...........|
-#> |    F| Forward Diff. |    -30.60 |    0.2182 |    -4.075 |   -0.4855 |
-#> |.....................|    -1.237 |   -0.6626 |   -0.1062 |    0.6612 |
-#> |.....................|   -0.6049 |     1.074 |     1.318 |     2.279 |
-#> |.....................|    -1.614 |    -1.745 |...........|...........|
-#> |   53|     447.16930 |     1.007 |    -1.971 |   -0.9627 |   -0.9652 |
-#> |.....................|   -0.9709 |     1.044 |    -2.781 |    -1.732 |
-#> |.....................|     2.691 |   -0.9472 |    -1.156 |   -0.5162 |
-#> |.....................|   -0.6828 |   -0.6632 |...........|...........|
-#> |    U|      447.1693 |     93.67 |    -6.271 |   -0.9883 |   -0.1807 |
-#> |.....................|     2.174 |     2.347 |  0.001652 |    0.6812 |
-#> |.....................|   0.08374 |    0.7063 |    0.6288 |     1.641 |
-#> |.....................|     1.268 |     1.293 |...........|...........|
-#> |    X|      447.1693 |     93.67 |  0.001890 |    0.2713 |    0.8346 |
-#> |.....................|     8.798 |     2.347 |  0.001652 |    0.6812 |
-#> |.....................|   0.08374 |    0.7063 |    0.6288 |     1.641 |
-#> |.....................|     1.268 |     1.293 |...........|...........|
-#> |    F| Forward Diff. |    -3.693 |    0.1048 |    0.8560 |   -0.3278 |
-#> |.....................|   -0.6115 |   -0.5188 |  -0.09596 |    0.9789 |
-#> |.....................|   0.02585 |     1.094 |     1.548 |     2.318 |
-#> |.....................|    -2.079 |   -0.9259 |...........|...........|
-#> |   54|     447.68852 |     1.013 |    -2.042 |    -1.008 |   -0.9421 |
-#> |.....................|   -0.9288 |     1.034 |    -2.709 |    -1.852 |
-#> |.....................|     3.037 |   -0.9368 |    -1.153 |   -0.6162 |
-#> |.....................|   -0.5399 |   -0.6984 |...........|...........|
-#> |    U|     447.68852 |     94.21 |    -6.342 |    -1.031 |   -0.1577 |
-#> |.....................|     2.217 |     2.341 |  0.002735 |    0.6094 |
-#> |.....................|   0.08893 |    0.7142 |    0.6313 |     1.519 |
-#> |.....................|     1.420 |     1.255 |...........|...........|
-#> |    X|     447.68852 |     94.21 |  0.001761 |    0.2629 |    0.8541 |
-#> |.....................|     9.176 |     2.341 |  0.002735 |    0.6094 |
-#> |.....................|   0.08893 |    0.7142 |    0.6313 |     1.519 |
-#> |.....................|     1.420 |     1.255 |...........|...........|
-#> |   55|     447.15405 |     1.011 |    -1.991 |   -0.9760 |   -0.9584 |
-#> |.....................|   -0.9586 |     1.042 |    -2.761 |    -1.767 |
-#> |.....................|     2.789 |   -0.9450 |    -1.157 |   -0.5460 |
-#> |.....................|   -0.6410 |   -0.6726 |...........|...........|
-#> |    U|     447.15405 |     94.04 |    -6.291 |    -1.001 |   -0.1740 |
-#> |.....................|     2.187 |     2.346 |  0.001959 |    0.6605 |
-#> |.....................|   0.08521 |    0.7080 |    0.6287 |     1.605 |
-#> |.....................|     1.312 |     1.283 |...........|...........|
-#> |    X|     447.15405 |     94.04 |  0.001852 |    0.2688 |    0.8403 |
-#> |.....................|     8.906 |     2.346 |  0.001959 |    0.6605 |
-#> |.....................|   0.08521 |    0.7080 |    0.6287 |     1.605 |
-#> |.....................|     1.312 |     1.283 |...........|...........|
-#> |    F| Forward Diff. |     53.59 |   0.07914 |    0.2662 |   -0.1234 |
-#> |.....................|   -0.1097 |   -0.6518 |  -0.06086 |    0.6193 |
-#> |.....................|  -0.05679 |     1.445 |    0.6511 |     1.197 |
-#> |.....................|   -0.1794 |    -1.326 |...........|...........|
-#> |   56|     447.09915 |     1.005 |    -2.002 |   -0.9768 |   -0.9545 |
-#> |.....................|   -0.9567 |     1.042 |    -2.752 |    -1.789 |
-#> |.....................|     2.838 |   -0.9392 |    -1.155 |   -0.5617 |
-#> |.....................|   -0.6261 |   -0.6787 |...........|...........|
-#> |    U|     447.09915 |     93.47 |    -6.302 |    -1.002 |   -0.1701 |
-#> |.....................|     2.189 |     2.346 |  0.002096 |    0.6471 |
-#> |.....................|   0.08594 |    0.7123 |    0.6298 |     1.586 |
-#> |.....................|     1.328 |     1.276 |...........|...........|
-#> |    X|     447.09915 |     93.47 |  0.001833 |    0.2686 |    0.8436 |
-#> |.....................|     8.923 |     2.346 |  0.002096 |    0.6471 |
-#> |.....................|   0.08594 |    0.7123 |    0.6298 |     1.586 |
-#> |.....................|     1.328 |     1.276 |...........|...........|
-#> |    F| Forward Diff. |    -33.97 |   0.05091 |   -0.1219 |  -0.09607 |
-#> |.....................|   -0.3249 |   -0.8735 |   -0.1278 |    0.5888 |
-#> |.....................|   0.06635 |     1.636 |    -1.923 |    0.5172 |
-#> |.....................|    0.5270 |    -1.419 |...........|...........|
-#> |   57|     447.01951 |     1.007 |    -2.009 |   -0.9874 |   -0.9450 |
-#> |.....................|   -0.9329 |     1.053 |    -2.780 |    -1.808 |
-#> |.....................|     2.841 |   -0.9693 |    -1.155 |   -0.5556 |
-#> |.....................|   -0.6514 |   -0.6721 |...........|...........|
-#> |    U|     447.01951 |     93.64 |    -6.309 |    -1.012 |   -0.1606 |
-#> |.....................|     2.212 |     2.352 |  0.001680 |    0.6361 |
-#> |.....................|   0.08598 |    0.6895 |    0.6300 |     1.593 |
-#> |.....................|     1.301 |     1.283 |...........|...........|
-#> |    X|     447.01951 |     93.64 |  0.001820 |    0.2667 |    0.8517 |
-#> |.....................|     9.138 |     2.352 |  0.001680 |    0.6361 |
-#> |.....................|   0.08598 |    0.6895 |    0.6300 |     1.593 |
-#> |.....................|     1.301 |     1.283 |...........|...........|
-#> |    F| Forward Diff. |    -6.500 |   0.04518 |   -0.6412 |    0.1616 |
-#> |.....................|    0.3106 |   -0.6054 |  -0.07873 |   -0.1077 |
-#> |.....................|   -0.1002 |    0.2460 |     1.553 |    0.4490 |
-#> |.....................|   -0.8245 |    -1.132 |...........|...........|
-#> |   58|     447.04861 |     1.009 |    -2.019 |   -0.9927 |   -0.9476 |
-#> |.....................|   -0.9252 |     1.054 |    -2.796 |    -1.779 |
-#> |.....................|     2.878 |   -0.9737 |    -1.157 |   -0.5487 |
-#> |.....................|   -0.6291 |   -0.6521 |...........|...........|
-#> |    U|     447.04861 |     93.85 |    -6.319 |    -1.017 |   -0.1632 |
-#> |.....................|     2.220 |     2.353 |  0.001429 |    0.6532 |
-#> |.....................|   0.08654 |    0.6862 |    0.6280 |     1.601 |
-#> |.....................|     1.325 |     1.305 |...........|...........|
-#> |    X|     447.04861 |     93.85 |  0.001802 |    0.2657 |    0.8494 |
-#> |.....................|     9.209 |     2.353 |  0.001429 |    0.6532 |
-#> |.....................|   0.08654 |    0.6862 |    0.6280 |     1.601 |
-#> |.....................|     1.325 |     1.305 |...........|...........|
-#> |   59|     447.01937 |     1.009 |    -2.012 |   -0.9891 |   -0.9459 |
-#> |.....................|   -0.9304 |     1.053 |    -2.785 |    -1.798 |
-#> |.....................|     2.853 |   -0.9708 |    -1.156 |   -0.5534 |
-#> |.....................|   -0.6439 |   -0.6653 |...........|...........|
-#> |    U|     447.01937 |     93.80 |    -6.312 |    -1.013 |   -0.1615 |
-#> |.....................|     2.215 |     2.353 |  0.001597 |    0.6418 |
-#> |.....................|   0.08617 |    0.6884 |    0.6292 |     1.596 |
-#> |.....................|     1.309 |     1.291 |...........|...........|
-#> |    X|     447.01937 |     93.80 |  0.001814 |    0.2664 |    0.8509 |
-#> |.....................|     9.161 |     2.353 |  0.001597 |    0.6418 |
-#> |.....................|   0.08617 |    0.6884 |    0.6292 |     1.596 |
-#> |.....................|     1.309 |     1.291 |...........|...........|
-#> |    F| Forward Diff. |     15.62 |   0.04451 |   -0.6370 |    0.1658 |
-#> |.....................|    0.4720 |   -0.4967 |  -0.06076 |    0.2478 |
-#> |.....................|   0.07878 |    0.2929 |    0.7908 |    0.7364 |
-#> |.....................|   -0.2169 |   -0.8458 |...........|...........|
-#> |   60|     447.00331 |     1.007 |    -2.016 |   -0.9874 |   -0.9487 |
-#> |.....................|   -0.9321 |     1.057 |    -2.790 |    -1.800 |
-#> |.....................|     2.856 |   -0.9696 |    -1.156 |   -0.5575 |
-#> |.....................|   -0.6423 |   -0.6633 |...........|...........|
-#> |    U|     447.00331 |     93.68 |    -6.316 |    -1.012 |   -0.1643 |
-#> |.....................|     2.213 |     2.355 |  0.001526 |    0.6406 |
-#> |.....................|   0.08622 |    0.6893 |    0.6295 |     1.591 |
-#> |.....................|     1.311 |     1.293 |...........|...........|
-#> |    X|     447.00331 |     93.68 |  0.001807 |    0.2667 |    0.8485 |
-#> |.....................|     9.146 |     2.355 |  0.001526 |    0.6406 |
-#> |.....................|   0.08622 |    0.6893 |    0.6295 |     1.591 |
-#> |.....................|     1.311 |     1.293 |...........|...........|
-#> |    F| Forward Diff. |    -1.749 |   0.03581 |   -0.6032 |   0.06997 |
-#> |.....................|    0.3775 |   -0.4012 |  -0.08782 |    0.2553 |
-#> |.....................|  0.001918 |    0.1783 |     1.513 |    0.3567 |
-#> |.....................|   -0.3333 |   -0.7379 |...........|...........|
-#> |   61|     446.99944 |     1.008 |    -2.018 |   -0.9851 |   -0.9476 |
-#> |.....................|   -0.9359 |     1.058 |    -2.787 |    -1.806 |
-#> |.....................|     2.859 |   -0.9671 |    -1.156 |   -0.5614 |
-#> |.....................|   -0.6427 |   -0.6650 |...........|...........|
-#> |    U|     446.99944 |     93.70 |    -6.318 |    -1.009 |   -0.1632 |
-#> |.....................|     2.209 |     2.355 |  0.001564 |    0.6369 |
-#> |.....................|   0.08626 |    0.6911 |    0.6291 |     1.586 |
-#> |.....................|     1.311 |     1.291 |...........|...........|
-#> |    X|     446.99944 |     93.70 |  0.001804 |    0.2671 |    0.8494 |
-#> |.....................|     9.111 |     2.355 |  0.001564 |    0.6369 |
-#> |.....................|   0.08626 |    0.6911 |    0.6291 |     1.586 |
-#> |.....................|     1.311 |     1.291 |...........|...........|
-#> |    F| Forward Diff. |     2.474 |   0.03546 |   -0.4554 |    0.1057 |
-#> |.....................|    0.2777 |   -0.4692 |  -0.06549 |   0.06429 |
-#> |.....................|  -0.09650 |    0.2331 |    0.6150 |    0.1626 |
-#> |.....................|   -0.3753 |   -0.8072 |...........|...........|
-#> |   62|     446.99641 |     1.007 |    -2.020 |   -0.9846 |   -0.9460 |
-#> |.....................|   -0.9366 |     1.059 |    -2.790 |    -1.808 |
-#> |.....................|     2.868 |   -0.9676 |    -1.156 |   -0.5621 |
-#> |.....................|   -0.6420 |   -0.6633 |...........|...........|
-#> |    U|     446.99641 |     93.67 |    -6.320 |    -1.009 |   -0.1616 |
-#> |.....................|     2.209 |     2.356 |  0.001530 |    0.6356 |
-#> |.....................|   0.08639 |    0.6908 |    0.6287 |     1.585 |
-#> |.....................|     1.311 |     1.293 |...........|...........|
-#> |    X|     446.99641 |     93.67 |  0.001800 |    0.2672 |    0.8508 |
-#> |.....................|     9.105 |     2.356 |  0.001530 |    0.6356 |
-#> |.....................|   0.08639 |    0.6908 |    0.6287 |     1.585 |
-#> |.....................|     1.311 |     1.293 |...........|...........|
-#> |    F| Forward Diff. |    -2.070 |   0.03317 |   -0.4443 |    0.1488 |
-#> |.....................|    0.2478 |   -0.4968 |  -0.07674 |   0.09423 |
-#> |.....................|  -0.05318 |    0.2365 |    0.6058 |    0.5619 |
-#> |.....................|   -0.3013 |   -0.7224 |...........|...........|
-#> |   63|     446.99641 |     1.007 |    -2.020 |   -0.9846 |   -0.9460 |
-#> |.....................|   -0.9366 |     1.059 |    -2.790 |    -1.808 |
-#> |.....................|     2.868 |   -0.9676 |    -1.156 |   -0.5621 |
-#> |.....................|   -0.6420 |   -0.6633 |...........|...........|
-#> |    U|     446.99641 |     93.67 |    -6.320 |    -1.009 |   -0.1616 |
-#> |.....................|     2.209 |     2.356 |  0.001530 |    0.6356 |
-#> |.....................|   0.08639 |    0.6908 |    0.6287 |     1.585 |
-#> |.....................|     1.311 |     1.293 |...........|...........|
-#> |    X|     446.99641 |     93.67 |  0.001800 |    0.2672 |    0.8508 |
-#> |.....................|     9.105 |     2.356 |  0.001530 |    0.6356 |
-#> |.....................|   0.08639 |    0.6908 |    0.6287 |     1.585 |
-#> |.....................|     1.311 |     1.293 |...........|...........|
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-f_nlmixr_dfop_sfo_saem_obs_tc <- nlmixr(f_mmkin_tc["DFOP-SFO", ], est = "saem",
-  error_model = "obs_tc")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#>  
-#> 1:    90.7519   -4.8586   -1.7674   -3.5599   -2.0059    0.5800    4.8899    1.4250    1.1400    2.6923    0.4845    0.4370   10.2815    0.0004    9.0437    0.4047
-#> 2:    9.0763e+01  -5.2004e+00  -1.9605e+00  -4.2009e+00  -1.8767e+00   2.0341e-01   4.6454e+00   1.3537e+00   1.0830e+00   2.7771e+00   4.6027e-01   5.1181e-01   6.3469e+00   4.0033e-04   6.8216e+00   9.0448e-05
-#> 3:    9.0656e+01  -5.4820e+00  -2.0937e+00  -4.0962e+00  -1.5381e+00  -1.7136e-02   4.4131e+00   1.2861e+00   1.0288e+00   3.5620e+00   4.3726e-01   6.1217e-01   4.8763e+00   4.1436e-05   5.4967e+00   1.0148e-05
-#> 4:    9.0543e+01  -5.7744e+00  -2.1074e+00  -4.0393e+00  -1.3603e+00  -2.3531e-01   5.0162e+00   1.2218e+00   1.0041e+00   3.3839e+00   4.1540e-01   5.8157e-01   4.1029e+00   2.1466e-04   4.2869e+00   1.9419e-06
-#> 5:    91.1621   -6.0534   -2.0430   -4.0508   -1.2523   -0.2043    6.1015    1.1715    1.1998    3.2147    0.3946    0.5525    3.5979    0.0187    3.8221    0.0271
-#> 6:    91.1179   -5.9892   -2.0082   -4.1363   -1.1428   -0.1930    5.7964    1.1960    1.2360    3.4525    0.3749    0.5293    3.3091    0.0209    3.6230    0.0284
-#> 7:    91.6680   -5.9609   -2.0492   -4.1163   -1.0919   -0.1505    5.6134    1.6750    1.3055    3.2799    0.3631    0.5028    3.2412    0.0254    3.5108    0.0371
-#> 8:    91.6903   -5.9346   -2.0630   -4.0790   -1.1130   -0.0963    5.3327    2.2525    1.3524    3.1159    0.3449    0.4777    2.6165    0.0445    2.8556    0.0576
-#> 9:    92.2564   -5.7600   -2.0460   -4.1144   -1.0635   -0.0594    5.9616    2.1399    1.2848    2.9601    0.3277    0.4538    2.3593    0.0295    2.5704    0.0491
-#> 10:    92.2425   -5.7990   -2.0052   -4.0409   -1.0387   -0.1141    6.9547    2.1239    1.2205    2.8121    0.3113    0.4311    2.3237    0.0323    2.4227    0.0421
-#> 11:    92.4404   -5.6829   -2.0866   -4.0010   -1.0214   -0.0587    6.6790    2.0177    1.1595    2.6715    0.2957    0.4096    1.9963    0.0407    2.2478    0.0501
-#> 12:    92.0713   -5.8051   -2.1699   -4.0539   -0.9807    0.0174    6.7885    2.1380    1.1811    2.6017    0.2810    0.3891    1.8480    0.0502    2.0516    0.0522
-#> 13:    91.7214   -5.6954   -2.1579   -4.0944   -0.9935   -0.0195    6.4491    2.0311    1.1221    2.4716    0.2669    0.3696    1.8299    0.0531    1.9271    0.0520
-#> 14:    91.1978   -5.6733   -2.1988   -4.0794   -0.9387    0.0091    6.1267    1.9295    1.1589    2.3480    0.2536    0.3511    1.6357    0.0470    1.8899    0.0639
-#> 15:    91.3746   -5.5864   -2.1484   -4.1356   -0.9126    0.0045    5.8203    1.8330    1.2078    2.3265    0.2409    0.3336    1.6218    0.0428    1.6558    0.0725
-#> 16:    91.5646   -5.4931   -2.1474   -4.1242   -0.9148    0.0179    5.5293    1.7414    1.1474    2.2733    0.2288    0.3169    1.6467    0.0377    1.6977    0.0600
-#> 17:    91.4767   -5.5885   -2.1424   -4.1386   -0.9308    0.0602    5.2528    1.9428    1.2141    2.1762    0.2174    0.3343    1.4916    0.0424    1.4326    0.0717
-#> 18:    90.9989   -5.6364   -2.1601   -4.1606   -0.9676    0.0694    4.9902    1.8457    1.2521    2.2899    0.2065    0.3279    1.4504    0.0471    1.4267    0.0700
-#> 19:    91.4050   -5.7347   -2.0985   -4.1476   -0.9656    0.0668    4.7407    2.3263    1.4064    2.2061    0.1962    0.3296    1.3679    0.0485    1.2735    0.0844
-#> 20:    91.2707   -5.7623   -2.1155   -4.1538   -0.9601    0.0425    4.5037    2.6509    1.3408    2.1958    0.1864    0.3576    1.3736    0.0452    1.3454    0.0743
-#> 21:    91.6878   -5.8143   -2.1261   -4.1649   -0.9325    0.0333    4.7695    2.8996    1.3244    2.1300    0.1771    0.3509    1.4793    0.0508    1.0333    0.0839
-#> 22:    91.5363   -5.9047   -2.1358   -4.1655   -0.9207    0.0339    4.5310    3.4408    1.3022    2.1829    0.1682    0.3378    1.4260    0.0488    0.9436    0.0877
-#> 23:    91.9969   -5.9565   -2.1378   -4.1609   -0.9243    0.0701    4.3045    3.7239    1.3446    2.2424    0.1598    0.3209    1.4182    0.0412    0.9205    0.0873
-#> 24:    92.2835   -5.9272   -2.0883   -4.1651   -0.9248    0.0834    4.0892    3.7780    1.2773    2.2187    0.1518    0.3049    1.4749    0.0427    0.9837    0.0802
-#> 25:    92.3389   -6.1292   -2.1033   -4.2473   -0.9069    0.0593    3.8848    4.7059    1.2740    2.4323    0.1442    0.2896    1.3656    0.0493    0.9299    0.0798
-#> 26:    91.9840   -5.9821   -2.1124   -4.2150   -0.9100    0.1076    3.6905    4.4706    1.2103    2.4699    0.1458    0.2751    1.3200    0.0504    0.8256    0.0912
-#> 27:    92.4671   -5.8765   -2.0910   -4.2169   -0.9356    0.0483    3.5060    4.2471    1.2302    2.4791    0.1385    0.2614    1.4252    0.0520    0.8191    0.0836
-#> 28:    92.4130   -5.9480   -2.0870   -4.2191   -0.9338    0.0866    3.3859    4.1337    1.2210    2.4685    0.1412    0.2557    1.3860    0.0484    0.9189    0.0770
-#> 29:    92.3064   -5.7845   -2.0759   -4.2321   -0.9270    0.0855    4.2691    3.9271    1.3369    2.5457    0.1341    0.2922    1.3848    0.0513    0.9658    0.0785
-#> 30:    92.2109   -5.9347   -2.0725   -4.2042   -0.9074    0.0481    5.5659    3.9234    1.2701    2.4184    0.1370    0.2776    1.2925    0.0560    0.9058    0.0806
-#> 31:    91.8912   -5.7466   -2.0912   -4.1504   -0.9087    0.0443    5.2876    3.7272    1.2690    2.2975    0.1301    0.2637    1.3348    0.0517    0.8672    0.0840
-#> 32:    92.3866   -5.8560   -2.0979   -4.1547   -0.9044    0.0335    5.0232    3.5408    1.2761    2.3185    0.1307    0.2505    1.3558    0.0487    0.9422    0.0791
-#> 33:    92.4555   -5.6989   -2.0956   -4.1479   -0.9038    0.0447    4.7720    3.3638    1.3253    2.2962    0.1242    0.2380    1.4321    0.0432    0.8961    0.0799
-#> 34:    92.6307   -5.8831   -2.0769   -4.1319   -0.8946    0.0430    4.5334    3.7151    1.2785    2.2638    0.1201    0.2261    1.4076    0.0457    0.8269    0.0813
-#> 35:    92.5659   -5.9100   -2.0748   -4.1482   -0.9079    0.0563    4.6634    3.7452    1.3141    2.3378    0.1168    0.2148    1.3571    0.0451    0.8317    0.0831
-#> 36:    92.5738   -5.8574   -2.0981   -4.1214   -0.8963    0.0302    5.3272    3.7371    1.3359    2.2776    0.1331    0.2041    1.3308    0.0480    0.8953    0.0791
-#> 37:    92.1615   -5.7137   -2.0922   -4.1178   -0.9035    0.0455    5.4894    3.5503    1.2691    2.2508    0.1473    0.1939    1.3692    0.0495    0.9358    0.0800
-#> 38:    92.4421   -5.6978   -2.0905   -4.1275   -0.9052    0.0108    5.4295    3.3728    1.2057    2.2119    0.1432    0.1842    1.3421    0.0549    0.8932    0.0781
-#> 39:    92.3995   -5.6121   -2.0804   -4.1275   -0.8903    0.0270    5.1580    3.2041    1.1454    2.2119    0.1360    0.1978    1.3353    0.0524    0.9062    0.0775
-#> 40:    92.5616   -5.7907   -2.1099   -4.1127   -0.9074    0.0501    4.9001    3.0439    1.1582    2.1723    0.1387    0.1879    1.2981    0.0510    0.9517    0.0797
-#> 41:    92.2655   -5.6532   -2.0631   -4.1437   -0.9128    0.0346    4.6551    2.8917    1.1202    2.1498    0.1403    0.1785    1.4500    0.0461    0.7394    0.0903
-#> 42:    92.3218   -5.4916   -2.1072   -4.1312   -0.9310    0.0360    4.4224    2.7471    1.1648    2.1428    0.1332    0.1695    1.4034    0.0508    0.8131    0.0854
-#> 43:    92.6165   -5.5145   -2.0838   -4.1239   -0.9215    0.0347    4.2012    2.6098    1.1892    2.1202    0.1463    0.1611    1.3416    0.0507    0.8213    0.0847
-#> 44:    92.5385   -5.5590   -2.0872   -4.1376   -0.9210    0.0672    3.9912    2.4793    1.1416    2.2253    0.1450    0.1530    1.4008    0.0352    0.8639    0.0847
-#> 45:    92.2152   -5.6170   -2.1014   -4.1657   -0.9331    0.0781    3.7916    2.4382    1.1250    2.2378    0.1516    0.1556    1.4612    0.0329    1.0091    0.0820
-#> 46:    91.8943   -5.6650   -2.1329   -4.1649   -0.9241    0.1060    3.6020    2.6448    1.0705    2.3112    0.1441    0.1549    1.5047    0.0384    1.0179    0.0805
-#> 47:    91.8153   -5.5910   -2.1514   -4.1919   -0.9169    0.0885    3.4219    2.5125    1.0386    2.3140    0.1506    0.1620    1.4759    0.0375    1.1021    0.0740
-#> 48:    91.6295   -5.5438   -2.1516   -4.1570   -0.8742    0.0851    3.2508    2.3869    1.0816    2.1983    0.1630    0.1786    1.4024    0.0405    1.1135    0.0732
-#> 49:    91.4363   -5.5847   -2.1732   -4.1794   -0.8634    0.0948    3.0883    2.4829    1.0865    2.2378    0.1549    0.1697    1.4314    0.0434    1.0529    0.0742
-#> 50:    91.3634   -5.5794   -2.1613   -4.1507   -0.8849    0.0862    2.9339    2.6404    1.0829    2.2519    0.1493    0.1612    1.3704    0.0446    1.0081    0.0736
-#> 51:    91.2150   -5.5503   -2.1675   -4.1432   -0.8749    0.1178    2.7872    2.7368    1.0605    2.2261    0.1418    0.1532    1.4312    0.0418    1.0380    0.0781
-#> 52:    91.4343   -5.6336   -2.2138   -4.1552   -0.8867    0.1391    2.6677    2.7022    1.0857    2.2588    0.1493    0.1455    1.3220    0.0469    0.9272    0.0761
-#> 53:    91.3310   -5.5185   -2.2340   -4.1430   -0.8855    0.1545    2.9130    2.5670    1.0720    2.3074    0.1532    0.1385    1.3224    0.0503    0.9688    0.0723
-#> 54:    91.4342   -5.5008   -2.2086   -4.1777   -0.8720    0.1688    2.8202    2.4387    1.0624    2.4253    0.1631    0.1315    1.3186    0.0429    0.9425    0.0723
-#> 55:    91.4983   -5.5944   -2.1709   -4.1211   -0.8638    0.1168    3.4789    2.5154    1.0549    2.3041    0.1557    0.1279    1.3800    0.0423    0.9620    0.0727
-#> 56:    91.5954   -5.5317   -2.1881   -4.1263   -0.8627    0.1366    4.1396    2.3896    1.0732    2.2684    0.1562    0.1221    1.3285    0.0431    1.0156    0.0708
-#> 57:    91.6591   -5.3839   -2.2082   -4.1122   -0.8929    0.1457    4.5073    2.2701    1.0672    2.3639    0.1539    0.1160    1.4074    0.0478    0.9796    0.0722
-#> 58:    91.7434   -5.3597   -2.2068   -4.1214   -0.8912    0.1437    4.2819    2.1566    1.0605    2.4496    0.1667    0.1109    1.4274    0.0450    1.0782    0.0676
-#> 59:    91.6597   -5.4672   -2.1918   -4.1412   -0.9021    0.1657    4.0678    2.0488    1.1306    2.5245    0.1888    0.1054    1.4745    0.0391    1.1492    0.0670
-#> 60:    91.7565   -5.4513   -2.2051   -4.1618   -0.9013    0.1554    3.8644    1.9464    1.1728    2.6191    0.1793    0.1001    1.4135    0.0402    1.1572    0.0665
-#> 61:    91.9484   -5.5390   -2.1973   -4.1611   -0.9011    0.1318    3.6712    1.8963    1.1460    2.6242    0.1704    0.0951    1.3855    0.0481    1.1109    0.0634
-#> 62:    92.1661   -5.4985   -2.1729   -4.1352   -0.8887    0.1327    4.3155    1.8588    1.1087    2.5551    0.1633    0.0995    1.3847    0.0444    1.0736    0.0656
-#> 63:    92.1727   -5.4086   -2.1610   -4.1488   -0.8998    0.1451    4.6019    1.7659    1.1413    2.6020    0.1718    0.1152    1.4299    0.0404    1.2202    0.0603
-#> 64:    92.4331   -5.5220   -2.1121   -4.1300   -0.9428    0.1211    5.0354    1.8121    1.0982    2.6157    0.1775    0.1209    1.4168    0.0348    1.2148    0.0625
-#> 65:    92.1871   -5.6089   -2.1258   -4.1412   -0.9127    0.1399    4.7836    2.1060    1.1568    2.5971    0.1757    0.1148    1.4000    0.0336    1.0305    0.0707
-#> 66:    92.1419   -5.7752   -2.1344   -4.1493   -0.9237    0.1494    4.5444    2.7076    1.1563    2.6439    0.1740    0.1091    1.4238    0.0341    1.0285    0.0688
-#> 67:    92.1187   -5.5967   -2.1430   -4.1460   -0.9074    0.1245    4.3172    2.5722    1.2052    2.6139    0.1868    0.1104    1.4100    0.0381    1.0508    0.0703
-#> 68:    92.1123   -5.6882   -2.1481   -4.1269   -0.9083    0.1206    4.1014    2.5548    1.2021    2.4832    0.1781    0.1462    1.3099    0.0417    1.0099    0.0713
-#> 69:    92.2511   -5.6923   -2.1456   -4.1315   -0.9077    0.1421    4.3551    2.6261    1.1850    2.3591    0.1692    0.1389    1.3546    0.0416    0.9516    0.0762
-#> 70:    92.0291   -5.7376   -2.1689   -4.1364   -0.8908    0.1407    4.1373    3.0520    1.1595    2.2495    0.1608    0.1465    1.3226    0.0436    0.9904    0.0711
-#> 71:    91.7690   -5.7223   -2.1773   -4.1986   -0.9036    0.1831    3.9304    2.8994    1.1015    2.4335    0.1527    0.1602    1.3135    0.0450    0.9564    0.0722
-#> 72:    91.4802   -5.7302   -2.2079   -4.2000   -0.8990    0.2112    3.7339    3.2965    1.1222    2.4612    0.1451    0.1622    1.3222    0.0426    1.0215    0.0717
-#> 73:    91.1247   -5.7803   -2.1827   -4.2214   -0.8876    0.1385    3.5472    3.2786    1.1612    2.5216    0.1650    0.1541    1.2811    0.0493    1.0076    0.0696
-#> 74:    90.9765   -5.6534   -2.1808   -4.2511   -0.8824    0.1308    3.8553    3.1146    1.1389    2.8140    0.1725    0.1464    1.2895    0.0518    1.0100    0.0707
-#> 75:    90.4805   -5.7293   -2.1481   -4.2613   -0.8704    0.1395    4.1255    2.9589    1.1623    2.7523    0.1713    0.1391    1.3112    0.0483    0.9439    0.0788
-#> 76:    90.3958   -5.7635   -2.1508   -4.2426   -0.8841    0.1402    4.7427    3.0223    1.2187    2.7243    0.1789    0.1321    1.3065    0.0468    0.9303    0.0758
-#> 77:    90.7518   -5.6517   -2.1498   -4.2773   -0.8730    0.1688    5.9340    2.8712    1.1840    2.8530    0.1828    0.1255    1.3553    0.0422    0.9755    0.0696
-#> 78:    91.0443   -5.7462   -2.1351   -4.2601   -0.8848    0.1746    5.6373    2.9912    1.1312    2.7659    0.1887    0.1192    1.3303    0.0410    0.8578    0.0744
-#> 79:    90.9631   -5.7307   -2.1618   -4.2593   -0.8965    0.1944    5.7520    3.1324    1.1206    2.8212    0.1875    0.1340    1.3519    0.0449    0.9006    0.0799
-#> 80:    90.8703   -5.7665   -2.1989   -4.2476   -0.9122    0.1933    5.4644    3.4527    1.1063    2.7920    0.1781    0.1273    1.3014    0.0497    0.9305    0.0792
-#> 81:    90.7781   -5.8702   -2.1789   -4.2821   -0.8828    0.1793    5.1912    3.7553    1.0662    3.0568    0.1807    0.1209    1.3120    0.0472    0.9808    0.0772
-#> 82:    90.8137   -6.1164   -2.2001   -4.3046   -0.8912    0.1916    4.9316    4.9023    1.0714    3.1363    0.1716    0.1149    1.2724    0.0539    1.0644    0.0693
-#> 83:    90.9900   -6.2077   -2.1695   -4.3121   -0.8924    0.1722    6.7123    5.3290    1.1120    3.2733    0.1741    0.1091    1.2822    0.0510    1.0142    0.0715
-#> 84:    90.8158   -6.3282   -2.1595   -4.2907   -0.9096    0.1818    6.3767    5.9725    1.1342    3.2384    0.1763    0.1037    1.2704    0.0420    0.8891    0.0834
-#> 85:    90.5926   -6.2052   -2.1643   -4.2780   -0.9000    0.1579    6.0579    5.6739    1.1472    3.0765    0.1751    0.0985    1.3263    0.0433    0.9484    0.0814
-#> 86:    90.3804   -6.2707   -2.1470   -4.2627   -0.9260    0.1650    5.7550    5.5542    1.1135    2.9227    0.1956    0.0936    1.2747    0.0447    0.9731    0.0780
-#> 87:    90.8425   -6.4455   -2.1135   -4.2273   -0.9294    0.1491    5.4672    6.8599    1.0716    2.7765    0.1858    0.0928    1.3204    0.0427    1.0005    0.0744
-#> 88:    91.2019   -6.2302   -2.1362   -4.1982   -0.9333    0.1615    5.1939    6.5169    1.1221    2.7203    0.1841    0.0928    1.2689    0.0466    0.9914    0.0771
-#> 89:    90.9907   -6.4173   -2.1174   -4.2493   -0.9182    0.1628    4.9342    6.2408    1.1719    2.9614    0.1749    0.1021    1.3580    0.0403    1.0171    0.0775
-#> 90:    91.1666   -6.5154   -2.1219   -4.2011   -0.9210    0.1594    4.6875    7.4895    1.1930    2.8133    0.1745    0.0970    1.2500    0.0432    0.9467    0.0799
-#> 91:    91.0165   -6.5918   -2.1465   -4.2231   -0.9079    0.1382    4.9772    7.3172    1.1706    2.6789    0.1810    0.1032    1.2958    0.0458    1.1223    0.0639
-#> 92:    91.5386   -6.6567   -2.1376   -4.2247   -0.9358    0.1696    5.5955    7.4188    1.1543    2.6339    0.1754    0.0980    1.2894    0.0463    0.9927    0.0764
-#> 93:    92.2552   -6.5096   -2.1645   -4.2340   -0.9393    0.1798    5.3157    7.0479    1.1612    2.6312    0.1718    0.0931    1.3698    0.0431    1.2649    0.0579
-#> 94:    91.7588   -6.4124   -2.1795   -4.2305   -0.9265    0.1842    5.8275    6.6955    1.1988    2.6403    0.1891    0.0884    1.3022    0.0481    1.0741    0.0713
-#> 95:    91.6694   -6.2975   -2.1946   -4.2442   -0.9392    0.2004    5.5361    6.3607    1.1399    2.7164    0.1796    0.1027    1.2519    0.0513    1.0982    0.0724
-#> 96:    91.2252   -6.0124   -2.2316   -4.2701   -0.8946    0.2375    5.2593    6.0427    1.0829    2.7921    0.2024    0.1147    1.3343    0.0426    1.3064    0.0560
-#> 97:    91.0388   -5.9178   -2.2563   -4.2703   -0.9093    0.2304    5.6825    5.7405    1.0890    2.7678    0.2113    0.1090    1.3517    0.0484    1.4160    0.0493
-#> 98:    90.9013   -6.1325   -2.2597   -4.2776   -0.9133    0.2447    5.7546    5.4535    1.1028    2.6806    0.2130    0.1182    1.2983    0.0451    1.2436    0.0584
-#> 99:    91.2086   -6.0047   -2.2719   -4.2972   -0.9136    0.2738    5.4668    5.1808    1.1776    2.7160    0.2132    0.1123    1.3301    0.0431    1.1850    0.0628
-#> 100:    91.3181   -5.9175   -2.2311   -4.3202   -0.8947    0.2844    5.1935    4.9218    1.1187    2.8660    0.2289    0.1471    1.3409    0.0371    0.9566    0.0806
-#> 101:    91.5112   -5.7721   -2.2292   -4.3060   -0.8842    0.3006    6.3617    4.6757    1.0628    2.7227    0.2174    0.1500    1.3269    0.0407    1.2002    0.0592
-#> 102:    91.5205   -5.9982   -2.2162   -4.3041   -0.8813    0.3065    7.7957    4.4419    1.0320    2.7176    0.2290    0.1474    1.3218    0.0392    0.9685    0.0783
-#> 103:    91.2416   -5.7012   -2.2204   -4.3198   -0.8610    0.3180    7.4059    4.2198    1.0242    2.5817    0.2175    0.1714    1.3003    0.0395    0.9472    0.0825
-#> 104:    91.2662   -5.8136   -2.2357   -4.3063   -0.8700    0.3110    7.0356    4.0088    1.0024    2.4701    0.2067    0.1939    1.2806    0.0407    1.0387    0.0743
-#> 105:    91.4688   -5.7922   -2.2204   -4.3319   -0.8703    0.2767    6.6838    3.8084    0.9751    2.6368    0.1963    0.1967    1.3320    0.0470    1.2043    0.0580
-#> 106:    91.3665   -5.8505   -2.2225   -4.3614   -0.8757    0.2922    7.1982    3.6180    1.0018    2.6378    0.1865    0.2132    1.2613    0.0464    1.0683    0.0693
-#> 107:    91.4934   -5.8933   -2.1993   -4.3433   -0.9112    0.3267    6.8383    3.7379    0.9616    2.5329    0.1772    0.2169    1.2911    0.0449    1.0688    0.0731
-#> 108:    92.1268   -5.7807   -2.1863   -4.4348   -0.9273    0.3235    6.4964    3.5510    1.0093    2.9025    0.1718    0.2061    1.3153    0.0414    0.8982    0.0796
-#> 109:    91.6585   -5.9778   -2.2083   -4.3550   -0.9061    0.3339    6.1715    4.5778    1.0600    2.7574    0.1755    0.2163    1.2754    0.0382    0.8100    0.0868
-#> 110:    92.0456   -5.6784   -2.2236   -4.3483   -0.8911    0.3022    5.8630    4.3489    1.0427    2.6195    0.1667    0.2472    1.3782    0.0336    0.7819    0.0931
-#> 111:    92.2862   -5.6624   -2.1985   -4.3680   -0.9178    0.3156    5.5698    4.1315    1.0149    2.5443    0.1622    0.2348    1.3541    0.0415    0.7848    0.0868
-#> 112:    92.5436   -5.6572   -2.2134   -4.3290   -0.9267    0.3025    5.2913    3.9249    1.0720    2.5118    0.1541    0.2231    1.3798    0.0385    0.9087    0.0799
-#> 113:    92.5970   -5.6263   -2.2030   -4.3044   -0.9123    0.2856    5.0268    3.7287    1.1371    2.4674    0.1764    0.2119    1.3007    0.0455    0.8651    0.0850
-#> 114:    92.9227   -5.6379   -2.2032   -4.2926   -0.9187    0.3282    4.7754    3.5422    1.1022    2.4105    0.1676    0.2013    1.3103    0.0439    0.9003    0.0815
-#> 115:    92.7678   -5.8033   -2.1888   -4.2988   -0.9406    0.3026    4.5367    3.3651    1.1127    2.5043    0.1592    0.1913    1.3643    0.0420    0.9649    0.0800
-#> 116:    92.0655   -5.8531   -2.2033   -4.2989   -0.9487    0.3013    4.3098    3.6792    1.1260    2.4981    0.1513    0.1817    1.2783    0.0445    0.9812    0.0818
-#> 117:    92.2258   -5.7861   -2.2095   -4.3393   -0.9399    0.2998    4.0943    3.4952    1.0697    2.7102    0.1437    0.1752    1.3037    0.0426    0.9067    0.0786
-#> 118:    92.3560   -5.8080   -2.2058   -4.3166   -0.9480    0.2743    4.6025    3.3205    1.0709    2.6198    0.1432    0.1747    1.2850    0.0481    0.9236    0.0769
-#> 119:    92.0489   -5.7726   -2.1972   -4.2740   -0.9087    0.2627    4.3723    3.1544    1.0892    2.4888    0.1620    0.1660    1.2659    0.0435    0.8389    0.0832
-#> 120:    91.9163   -5.8211   -2.2101   -4.2770   -0.9142    0.2674    4.1537    3.1700    1.0985    2.5003    0.1795    0.1577    1.2289    0.0454    0.9280    0.0826
-#> 121:    92.0274   -5.7601   -2.1916   -4.2686   -0.9055    0.2571    3.9460    3.1181    1.1026    2.3985    0.1908    0.1498    1.3015    0.0432    0.9363    0.0807
-#> 122:    92.2933   -5.7972   -2.2019   -4.2888   -0.8932    0.2679    3.7487    3.1755    1.0809    2.3976    0.1843    0.1636    1.2918    0.0433    0.8760    0.0803
-#> 123:    92.3361   -5.8903   -2.1745   -4.3386   -0.9157    0.2665    3.5613    3.8794    1.1308    2.5838    0.1751    0.1555    1.3219    0.0421    0.8987    0.0806
-#> 124:    92.5677   -6.0471   -2.1638   -4.2764   -0.9325    0.2645    3.3832    4.6152    1.1336    2.4546    0.1664    0.1526    1.2938    0.0375    0.9412    0.0798
-#> 125:    92.7852   -5.9841   -2.1661   -4.2825   -0.9373    0.2866    3.2141    4.3844    1.0770    2.3788    0.1581    0.1727    1.3137    0.0417    0.9228    0.0733
-#> 126:    92.7867   -5.9126   -2.1636   -4.2413   -0.9141    0.2756    3.0534    4.1652    1.0857    2.2921    0.1502    0.1994    1.2428    0.0450    0.8206    0.0795
-#> 127:    92.8733   -5.9110   -2.1546   -4.2269   -0.9258    0.2531    2.9007    3.9569    1.0914    2.3822    0.1426    0.2029    1.3043    0.0369    0.8206    0.0795
-#> 128:    93.0457   -5.9202   -2.1505   -4.2076   -0.9466    0.2463    3.3353    3.7591    1.0647    2.3012    0.1355    0.2180    1.3420    0.0385    0.8503    0.0803
-#> 129:    92.9207   -5.9882   -2.1704   -4.2204   -0.9319    0.2464    4.3160    4.4368    1.1187    2.3415    0.1386    0.2316    1.2546    0.0435    0.8777    0.0830
-#> 130:    92.2660   -6.2043   -2.1712   -4.2251   -0.9276    0.2186    4.4370    5.1440    1.0817    2.3426    0.1338    0.2200    1.2733    0.0476    0.9132    0.0753
-#> 131:    92.1286   -6.4163   -2.1634   -4.2642   -0.9223    0.2300    4.2151    6.2253    1.0614    2.5012    0.1333    0.2090    1.2690    0.0430    0.8201    0.0814
-#> 132:    92.0287   -6.4297   -2.1522   -4.2717   -0.9259    0.2250    4.0044    6.1979    1.0791    2.5146    0.1314    0.1985    1.2736    0.0449    0.8671    0.0784
-#> 133:    91.6843   -6.1415   -2.1685   -4.2553   -0.9349    0.2209    3.8041    5.8880    1.1445    2.4277    0.1248    0.2026    1.3381    0.0426    0.9129    0.0858
-#> 134:    91.6928   -6.1408   -2.1467   -4.2709   -0.9270    0.2648    3.6139    5.5936    1.0873    2.5602    0.1305    0.1925    1.3202    0.0416    0.7626    0.0936
-#> 135:    91.7984   -6.0371   -2.1673   -4.2572   -0.9497    0.2480    3.4332    5.3139    1.0649    2.4322    0.1389    0.1829    1.2592    0.0544    0.9459    0.0831
-#> 136:    91.9754   -6.1770   -2.1769   -4.2311   -0.9401    0.2435    3.2616    5.0482    1.0717    2.3106    0.1691    0.1737    1.3170    0.0436    1.0497    0.0816
-#> 137:    92.1546   -6.1216   -2.1731   -4.2278   -0.9401    0.2492    3.0985    4.9378    1.0200    2.1950    0.1606    0.1988    1.4019    0.0421    1.0200    0.0766
-#> 138:    92.2370   -5.9463   -2.1794   -4.1949   -0.9321    0.2460    2.9436    4.6909    1.0203    2.1200    0.1535    0.1947    1.3378    0.0425    0.9448    0.0804
-#> 139:    92.2025   -5.8849   -2.1820   -4.1868   -0.9200    0.2294    2.9458    4.4564    0.9875    2.1260    0.1759    0.2080    1.3244    0.0428    1.0110    0.0778
-#> 140:    91.8182   -5.7494   -2.1569   -4.1998   -0.9095    0.2318    2.7985    4.2336    1.0015    2.1507    0.1830    0.2113    1.3502    0.0432    0.7716    0.0922
-#> 141:    91.8292   -5.9568   -2.1640   -4.2109   -0.9122    0.2130    4.4608    4.0219    1.0180    2.1032    0.1739    0.2057    1.3594    0.0419    0.8088    0.0883
-#> 142:    91.9995   -6.0927   -2.1471   -4.2313   -0.9091    0.1875    4.5415    4.7705    1.0571    2.1286    0.1810    0.1954    1.4145    0.0406    0.8943    0.0847
-#> 143:    91.9160   -5.9892   -2.1546   -4.2043   -0.9355    0.1819    4.3145    4.5320    1.1337    2.1453    0.1888    0.2208    1.3449    0.0394    1.0910    0.0797
-#> 144:    92.0136   -5.9765   -2.1643   -4.2346   -0.9448    0.2455    4.3041    4.3054    1.1130    2.1300    0.1817    0.3253    1.3828    0.0340    1.0535    0.0873
-#> 145:    92.3893   -6.2224   -2.1211   -4.2316   -0.9405    0.2285    5.2279    4.9099    1.0573    2.1037    0.1727    0.3091    1.3797    0.0340    1.0160    0.0832
-#> 146:    92.6097   -6.2204   -2.1406   -4.2210   -0.9217    0.1762    4.9665    5.4466    1.0724    2.1658    0.1640    0.2936    1.4421    0.0408    1.2412    0.0674
-#> 147:    92.8499   -6.0091   -2.1165   -4.2234   -0.9682    0.1783    4.7182    5.1743    1.0188    2.1714    0.1722    0.2789    1.4545    0.0397    1.4472    0.0556
-#> 148:    92.6602   -5.8003   -2.1059   -4.2132   -0.9282    0.2102    4.4823    4.9156    1.0106    2.1075    0.1880    0.2684    1.4013    0.0413    1.0748    0.0758
-#> 149:    92.7388   -5.8727   -2.1569   -4.2185   -0.9266    0.1868    4.2581    4.6698    1.1447    2.0851    0.1786    0.2550    1.3137    0.0413    0.9963    0.0723
-#> 150:    92.7348   -5.7926   -2.1184   -4.2257   -0.9324    0.1966    4.0452    4.4363    1.1760    2.1508    0.1697    0.2704    1.3792    0.0363    0.8204    0.0889
-#> 151:    92.7968   -5.7301   -2.1179   -4.1959   -0.9275    0.1927    3.8430    4.2145    1.1707    2.1702    0.1842    0.2569    1.3789    0.0387    0.7890    0.0873
-#> 152:    92.9011   -5.7417   -2.1622   -4.2086   -0.9215    0.1784    2.0089    3.0670    1.1984    2.2253    0.1814    0.2507    1.3431    0.0395    0.9622    0.0780
-#> 153:    92.8020   -5.7707   -2.1494   -4.2128   -0.9228    0.1818    2.2261    2.9648    1.1192    2.3058    0.1749    0.2548    1.3671    0.0369    0.9507    0.0744
-#> 154:    92.5217   -5.8043   -2.1447   -4.2074   -0.9303    0.1766    2.7638    3.1314    1.1141    2.2814    0.1811    0.2389    1.3250    0.0408    1.0538    0.0689
-#> 155:    92.8765   -5.5586   -2.1275   -4.1639   -0.9320    0.1434    2.4217    2.4658    1.1231    2.1314    0.1746    0.2426    1.3785    0.0407    0.9682    0.0796
-#> 156:    93.0074   -5.6819   -2.1343   -4.1819   -0.9382    0.1587    1.4756    2.7496    1.1200    2.1700    0.1849    0.2320    1.3643    0.0395    1.0875    0.0653
-#> 157:    92.7950   -5.6827   -2.1178   -4.1808   -0.9553    0.1585    1.1607    2.5156    1.1129    2.2109    0.1724    0.2366    1.4045    0.0374    1.1322    0.0676
-#> 158:    92.7684   -5.7106   -2.0933   -4.2149   -0.9717    0.1602    1.4884    2.6532    1.1269    2.1388    0.1838    0.2666    1.4009    0.0348    0.8728    0.0832
-#> 159:    93.0980   -5.8911   -2.1297   -4.2160   -0.9660    0.1407    1.6034    3.3765    1.1182    2.1661    0.1705    0.2804    1.3557    0.0430    1.0076    0.0776
-#> 160:    93.1849   -5.9433   -2.1177   -4.1735   -0.9436    0.1324    1.8692    4.0887    1.1252    2.0213    0.1642    0.2922    1.3251    0.0386    0.8586    0.0820
-#> 161:    93.4771   -5.7768   -2.0899   -4.1697   -0.9670    0.1043    2.0938    2.9110    1.1069    1.9538    0.1820    0.3046    1.3270    0.0413    0.8220    0.0855
-#> 162:    93.4961   -5.6516   -2.0965   -4.1633   -0.9708    0.1263    2.2053    2.3022    1.1179    1.9555    0.1758    0.2891    1.3158    0.0417    0.9943    0.0768
-#> 163:    93.1627   -5.5944   -2.1527   -4.1633   -0.9488    0.1452    2.9600    2.3291    1.1027    1.9555    0.1766    0.3000    1.3626    0.0376    0.9790    0.0743
-#> 164:    92.7951   -5.6646   -2.1539   -4.1699   -0.9447    0.1863    2.9195    2.7599    1.0794    1.9511    0.1651    0.2918    1.4091    0.0357    1.1005    0.0709
-#> 165:    92.6045   -5.5927   -2.1842   -4.1770   -0.9436    0.1939    2.2014    2.3213    1.0622    1.9775    0.1671    0.2899    1.3945    0.0372    1.0533    0.0694
-#> 166:    92.6660   -5.5922   -2.1438   -4.1611   -0.9441    0.1767    1.8951    2.3445    1.1025    2.0399    0.1802    0.2802    1.4229    0.0354    1.1552    0.0682
-#> 167:    92.4353   -5.5118   -2.1415   -4.1730   -0.9124    0.1827    1.5029    1.8145    1.0701    2.0090    0.1727    0.2642    1.4525    0.0362    1.0577    0.0754
-#> 168:    92.3761   -5.5522   -2.1625   -4.1911   -0.9114    0.1782    1.2703    2.0808    1.0814    2.0588    0.1810    0.2658    1.3973    0.0364    0.9874    0.0729
-#> 169:    92.5240   -5.6102   -2.1396   -4.1793   -0.8972    0.1722    1.3115    2.2750    1.0759    2.0910    0.2147    0.2549    1.3553    0.0392    0.9770    0.0759
-#> 170:    92.3827   -5.5942   -2.1231   -4.1847   -0.9338    0.1525    1.5707    2.3778    1.0542    2.0824    0.2042    0.2519    1.4424    0.0363    1.1270    0.0687
-#> 171:    92.1706   -5.6171   -2.1619   -4.1926   -0.9056    0.1390    1.0935    2.2869    1.1239    2.1697    0.1946    0.2624    1.2980    0.0411    0.9988    0.0740
-#> 172:    92.1491   -5.5704   -2.1447   -4.1913   -0.9285    0.1649    1.0292    2.2160    1.1231    2.1905    0.1860    0.2518    1.3154    0.0375    1.0152    0.0772
-#> 173:    91.9987   -5.5411   -2.1434   -4.1803   -0.9056    0.1585    0.6511    1.9989    1.0892    2.2283    0.1899    0.2413    1.3814    0.0380    1.1733    0.0693
-#> 174:    92.0377   -5.5419   -2.1081   -4.1928   -0.9057    0.1418    0.9013    2.0933    1.1813    2.2773    0.1756    0.2559    1.4419    0.0343    0.9942    0.0801
-#> 175:    92.0266   -5.5125   -2.1014   -4.1775   -0.9119    0.1371    0.7194    2.0624    1.1848    2.2328    0.1754    0.2504    1.3987    0.0353    1.0838    0.0728
-#> 176:    92.0365   -5.5658   -2.0914   -4.1646   -0.8956    0.1096    0.7557    2.0588    1.1642    2.1610    0.1617    0.2722    1.3658    0.0347    0.9405    0.0757
-#> 177:    91.8661   -5.6799   -2.0950   -4.1695   -0.9010    0.1193    0.8835    2.8899    1.1394    2.1886    0.1809    0.2777    1.3841    0.0351    0.9178    0.0794
-#> 178:    91.9392   -5.7853   -2.1139   -4.1711   -0.9190    0.1222    0.6673    3.0461    1.1712    2.1948    0.1576    0.2237    1.3623    0.0383    0.9060    0.0795
-#> 179:    92.0116   -5.7560   -2.1418   -4.1711   -0.9153    0.1034    0.4356    2.9139    1.1653    2.1948    0.1497    0.2364    1.3387    0.0392    0.9327    0.0793
-#> 180:    92.1013   -5.7920   -2.1368   -4.1654   -0.9059    0.0912    0.3859    3.2592    1.1357    2.1744    0.1570    0.2337    1.3622    0.0408    1.0299    0.0739
-#> 181:    92.1032   -5.8125   -2.1260   -4.1791   -0.9404    0.1731    0.4091    3.0817    1.1113    2.2356    0.1572    0.2742    1.4509    0.0340    0.9180    0.0865
-#> 182:    92.1315   -5.7991   -2.1327   -4.1737   -0.9319    0.1519    0.3145    3.0292    1.1520    2.1360    0.1661    0.2482    1.4105    0.0361    1.1338    0.0748
-#> 183:    92.1350   -6.0470   -2.1264   -4.1707   -0.9525    0.1787    0.2045    3.8296    1.1229    2.1369    0.1735    0.2453    1.3132    0.0350    1.0507    0.0759
-#> 184:    92.0539   -5.9856   -2.1289   -4.1968   -0.9281    0.1789    0.1166    3.9425    1.0558    2.2320    0.1658    0.2253    1.3390    0.0355    1.1271    0.0720
-#> 185:    92.0755   -6.0524   -2.1385   -4.2076   -0.9313    0.1794    0.1193    4.2430    1.0465    2.3571    0.1566    0.2152    1.3777    0.0368    1.2013    0.0631
-#> 186:    92.1639   -6.0663   -2.1399   -4.1869   -0.9311    0.1817    0.1392    4.4053    1.0495    2.4857    0.1532    0.2331    1.3751    0.0365    1.0497    0.0697
-#> 187:    92.1759   -6.3052   -2.1469   -4.2221   -0.9428    0.1970    0.1356    5.5622    0.9953    2.3367    0.1451    0.2359    1.3754    0.0367    1.0969    0.0656
-#> 188:    92.1744   -6.0494   -2.1406   -4.2445   -0.9595    0.2089    0.1364    4.3818    0.9882    2.4074    0.1480    0.2364    1.3709    0.0396    1.1259    0.0642
-#> 189:    92.1989   -6.1255   -2.1138   -4.2037   -0.9368    0.1796    0.1444    4.6756    0.9840    2.3786    0.1502    0.2303    1.3979    0.0393    1.2011    0.0630
-#> 190:    92.0944   -6.1343   -2.1536   -4.2106   -0.9267    0.2105    0.1288    4.4977    1.0475    2.3593    0.1443    0.2396    1.3247    0.0384    1.1304    0.0711
-#> 191:    92.1238   -6.0639   -2.1462   -4.2883   -0.9311    0.2155    0.1246    4.1066    1.0428    2.6836    0.1442    0.2344    1.4041    0.0344    1.1631    0.0684
-#> 192:    92.1328   -6.0743   -2.1232   -4.3119   -0.9586    0.2319    0.1192    4.1348    1.0020    2.7067    0.1466    0.2515    1.4039    0.0355    1.0021    0.0772
-#> 193:    92.0881   -5.8697   -2.1298   -4.2691   -0.9309    0.2295    0.1050    3.4476    0.9879    2.5496    0.1344    0.2348    1.4677    0.0351    1.0332    0.0705
-#> 194:    92.1086   -5.7557   -2.1176   -4.3249   -0.9029    0.2183    0.0702    2.7793    1.0043    2.8853    0.1460    0.2213    1.4733    0.0325    1.0929    0.0681
-#> 195:    92.1265   -5.8976   -2.1506   -4.2932   -0.9267    0.2511    0.0593    3.4959    0.9881    2.6806    0.1278    0.2505    1.6138    0.0350    1.1327    0.0703
-#> 196:    92.1316   -5.7018   -2.1627   -4.2889   -0.9278    0.2392    0.0717    2.9210    1.0160    2.7067    0.1470    0.2350    1.5063    0.0418    1.0525    0.0734
-#> 197:    92.1756   -5.7899   -2.1604   -4.2819   -0.9248    0.2765    0.0754    2.9991    1.0167    2.6170    0.1465    0.2314    1.4982    0.0387    1.0504    0.0774
-#> 198:    92.2153   -5.8248   -2.1571   -4.2245   -0.9350    0.2195    0.0651    3.0128    0.9196    2.3123    0.1451    0.2363    1.3965    0.0453    1.1561    0.0650
-#> 199:    92.1935   -5.8187   -2.1505   -4.2123   -0.9452    0.2406    0.0535    3.0017    0.9553    2.2771    0.1338    0.2415    1.4485    0.0407    1.0647    0.0699
-#> 200:    92.2308   -5.6732   -2.1578   -4.2182   -0.9324    0.2330    0.0618    2.4070    1.0687    2.2978    0.1513    0.2199    1.4101    0.0385    1.0283    0.0741
-#> 201:    92.2305   -5.6796   -2.1604   -4.2064   -0.9320    0.2262    0.0530    2.4360    1.0551    2.2994    0.1529    0.2219    1.3653    0.0407    1.0115    0.0757
-#> 202:    92.2259   -5.7201   -2.1550   -4.2058   -0.9263    0.2208    0.0461    2.6422    1.0351    2.2888    0.1520    0.2100    1.3739    0.0418    1.0474    0.0730
-#> 203:    92.2212   -5.7539   -2.1457   -4.2037   -0.9303    0.2163    0.0422    2.8480    1.0403    2.2723    0.1465    0.2070    1.3973    0.0404    1.0518    0.0729
-#> 204:    92.2164   -5.8068   -2.1371   -4.2093   -0.9300    0.2163    0.0383    3.1313    1.0426    2.2984    0.1423    0.2091    1.4025    0.0391    1.0284    0.0737
-#> 205:    92.2120   -5.8371   -2.1369   -4.2142   -0.9308    0.2156    0.0347    3.2786    1.0392    2.3249    0.1390    0.2048    1.4115    0.0385    1.0161    0.0733
-#> 206:    92.2071   -5.8681   -2.1391   -4.2176   -0.9287    0.2158    0.0336    3.4917    1.0442    2.3461    0.1388    0.2041    1.4017    0.0394    0.9977    0.0735
-#> 207:    92.2078   -5.8966   -2.1424   -4.2230   -0.9286    0.2181    0.0337    3.6741    1.0456    2.3743    0.1369    0.2009    1.3988    0.0397    0.9792    0.0740
-#> 208:    92.2077   -5.8972   -2.1459   -4.2249   -0.9300    0.2208    0.0340    3.6775    1.0460    2.3889    0.1362    0.1985    1.3969    0.0394    0.9729    0.0742
-#> 209:    92.2091   -5.8831   -2.1488   -4.2271   -0.9326    0.2227    0.0337    3.6019    1.0465    2.4005    0.1380    0.1967    1.3949    0.0395    0.9745    0.0741
-#> 210:    92.2115   -5.8806   -2.1490   -4.2282   -0.9349    0.2238    0.0324    3.5652    1.0516    2.4211    0.1386    0.1979    1.3941    0.0391    0.9820    0.0740
-#> 211:    92.2151   -5.8791   -2.1516   -4.2291   -0.9363    0.2258    0.0318    3.5315    1.0458    2.4465    0.1390    0.1989    1.3918    0.0394    0.9901    0.0735
-#> 212:    92.2189   -5.8789   -2.1532   -4.2297   -0.9380    0.2269    0.0312    3.4989    1.0434    2.4718    0.1409    0.1993    1.3884    0.0394    1.0007    0.0732
-#> 213:    92.2226   -5.8714   -2.1556   -4.2287   -0.9395    0.2255    0.0313    3.4460    1.0440    2.4800    0.1413    0.1993    1.3859    0.0397    1.0157    0.0722
-#> 214:    92.2233   -5.8706   -2.1553   -4.2279   -0.9394    0.2237    0.0309    3.4283    1.0431    2.4809    0.1414    0.2003    1.3849    0.0399    1.0186    0.0720
-#> 215:    92.2242   -5.8750   -2.1536   -4.2285   -0.9390    0.2212    0.0312    3.4442    1.0455    2.4800    0.1417    0.2015    1.3830    0.0401    1.0126    0.0723
-#> 216:    92.2252   -5.8788   -2.1521   -4.2277   -0.9393    0.2192    0.0316    3.4718    1.0459    2.4791    0.1410    0.2028    1.3817    0.0402    1.0046    0.0726
-#> 217:    92.2255   -5.8869   -2.1516   -4.2268   -0.9400    0.2177    0.0322    3.5295    1.0456    2.4751    0.1407    0.2042    1.3814    0.0401    1.0011    0.0729
-#> 218:    92.2230   -5.8819   -2.1511   -4.2259   -0.9400    0.2164    0.0327    3.5004    1.0473    2.4693    0.1399    0.2051    1.3784    0.0401    0.9962    0.0731
-#> 219:    92.2206   -5.8761   -2.1499   -4.2269   -0.9393    0.2156    0.0325    3.4736    1.0494    2.4667    0.1399    0.2066    1.3794    0.0399    0.9925    0.0734
-#> 220:    92.2185   -5.8775   -2.1494   -4.2267   -0.9380    0.2150    0.0331    3.4894    1.0511    2.4596    0.1396    0.2090    1.3788    0.0398    0.9881    0.0734
-#> 221:    92.2180   -5.8774   -2.1499   -4.2271   -0.9369    0.2142    0.0328    3.4873    1.0518    2.4559    0.1399    0.2109    1.3776    0.0399    0.9842    0.0735
-#> 222:    92.2191   -5.8833   -2.1503   -4.2280   -0.9359    0.2127    0.0328    3.5384    1.0518    2.4533    0.1400    0.2114    1.3778    0.0400    0.9825    0.0735
-#> 223:    92.2199   -5.8831   -2.1486   -4.2288   -0.9343    0.2112    0.0326    3.5474    1.0539    2.4515    0.1396    0.2127    1.3795    0.0398    0.9806    0.0735
-#> 224:    92.2206   -5.8870   -2.1467   -4.2283   -0.9331    0.2093    0.0324    3.5619    1.0550    2.4482    0.1395    0.2133    1.3805    0.0395    0.9792    0.0735
-#> 225:    92.2218   -5.8929   -2.1459   -4.2289   -0.9328    0.2086    0.0322    3.6001    1.0548    2.4492    0.1388    0.2142    1.3804    0.0393    0.9809    0.0734
-#> 226:    92.2228   -5.8909   -2.1440   -4.2293   -0.9322    0.2082    0.0320    3.6007    1.0566    2.4513    0.1383    0.2143    1.3826    0.0390    0.9815    0.0737
-#> 227:    92.2234   -5.8838   -2.1444   -4.2304   -0.9319    0.2088    0.0319    3.5748    1.0551    2.4562    0.1381    0.2140    1.3814    0.0390    0.9836    0.0736
-#> 228:    92.2243   -5.8835   -2.1444   -4.2314   -0.9326    0.2093    0.0317    3.5756    1.0526    2.4607    0.1377    0.2143    1.3824    0.0389    0.9901    0.0733
-#> 229:    92.2251   -5.8916   -2.1442   -4.2307   -0.9330    0.2095    0.0318    3.6344    1.0501    2.4580    0.1371    0.2148    1.3850    0.0388    0.9930    0.0733
-#> 230:    92.2250   -5.8951   -2.1442   -4.2303   -0.9334    0.2107    0.0318    3.6533    1.0475    2.4550    0.1369    0.2150    1.3872    0.0387    0.9953    0.0734
-#> 231:    92.2247   -5.8964   -2.1444   -4.2300   -0.9345    0.2119    0.0322    3.6564    1.0446    2.4549    0.1368    0.2151    1.3899    0.0388    0.9991    0.0733
-#> 232:    92.2230   -5.8982   -2.1451   -4.2306   -0.9352    0.2132    0.0326    3.6643    1.0422    2.4591    0.1365    0.2155    1.3934    0.0388    1.0052    0.0729
-#> 233:    92.2223   -5.9022   -2.1455   -4.2327   -0.9354    0.2141    0.0329    3.6824    1.0396    2.4697    0.1362    0.2165    1.3970    0.0388    1.0107    0.0726
-#> 234:    92.2200   -5.9075   -2.1457   -4.2324   -0.9348    0.2140    0.0335    3.7056    1.0364    2.4735    0.1366    0.2174    1.3977    0.0388    1.0163    0.0723
-#> 235:    92.2171   -5.9094   -2.1457   -4.2338   -0.9342    0.2142    0.0342    3.7222    1.0339    2.4854    0.1372    0.2189    1.3999    0.0389    1.0228    0.0721
-#> 236:    92.2161   -5.9195   -2.1464   -4.2368   -0.9340    0.2140    0.0346    3.7789    1.0329    2.4986    0.1376    0.2200    1.4007    0.0389    1.0281    0.0721
-#> 237:    92.2163   -5.9214   -2.1469   -4.2390   -0.9330    0.2143    0.0347    3.7862    1.0329    2.5074    0.1378    0.2195    1.4030    0.0389    1.0320    0.0719
-#> 238:    92.2165   -5.9203   -2.1473   -4.2399   -0.9326    0.2143    0.0347    3.7781    1.0336    2.5100    0.1381    0.2186    1.4031    0.0388    1.0347    0.0719
-#> 239:    92.2173   -5.9212   -2.1471   -4.2403   -0.9325    0.2136    0.0344    3.7908    1.0350    2.5128    0.1384    0.2175    1.4021    0.0389    1.0352    0.0718
-#> 240:    92.2178   -5.9217   -2.1470   -4.2394   -0.9322    0.2133    0.0342    3.8082    1.0363    2.5118    0.1384    0.2169    1.4025    0.0387    1.0345    0.0719
-#> 241:    92.2177   -5.9200   -2.1470   -4.2383   -0.9318    0.2136    0.0340    3.8123    1.0381    2.5110    0.1385    0.2161    1.4028    0.0387    1.0336    0.0720
-#> 242:    92.2170   -5.9109   -2.1478   -4.2371   -0.9308    0.2136    0.0340    3.7766    1.0387    2.5090    0.1385    0.2157    1.4027    0.0386    1.0322    0.0720
-#> 243:    92.2165   -5.9029   -2.1484   -4.2371   -0.9300    0.2140    0.0340    3.7433    1.0389    2.5128    0.1386    0.2150    1.4032    0.0385    1.0342    0.0720
-#> 244:    92.2161   -5.8998   -2.1489   -4.2374   -0.9294    0.2143    0.0340    3.7242    1.0392    2.5173    0.1386    0.2148    1.4030    0.0384    1.0343    0.0720
-#> 245:    92.2153   -5.9048   -2.1494   -4.2370   -0.9291    0.2149    0.0339    3.7491    1.0399    2.5182    0.1386    0.2146    1.4019    0.0383    1.0317    0.0722
-#> 246:    92.2147   -5.9093   -2.1498   -4.2371   -0.9289    0.2156    0.0339    3.7727    1.0409    2.5218    0.1384    0.2145    1.4016    0.0382    1.0309    0.0724
-#> 247:    92.2143   -5.9124   -2.1503   -4.2368   -0.9286    0.2159    0.0338    3.7972    1.0408    2.5232    0.1383    0.2144    1.4012    0.0382    1.0297    0.0725
-#> 248:    92.2137   -5.9122   -2.1500   -4.2367   -0.9286    0.2160    0.0336    3.8036    1.0409    2.5245    0.1382    0.2141    1.4022    0.0381    1.0272    0.0727
-#> 249:    92.2133   -5.9101   -2.1501   -4.2364   -0.9288    0.2160    0.0334    3.7984    1.0406    2.5268    0.1383    0.2136    1.4031    0.0381    1.0273    0.0726
-#> 250:    92.2139   -5.9115   -2.1502   -4.2368   -0.9289    0.2167    0.0335    3.8015    1.0412    2.5326    0.1380    0.2132    1.4035    0.0381    1.0261    0.0727
-#> 251:    92.2132   -5.9123   -2.1502   -4.2373   -0.9297    0.2170    0.0338    3.8015    1.0421    2.5362    0.1376    0.2126    1.4053    0.0379    1.0274    0.0727
-#> 252:    92.2128   -5.9106   -2.1502   -4.2366   -0.9299    0.2174    0.0338    3.7931    1.0427    2.5345    0.1371    0.2120    1.4062    0.0379    1.0262    0.0728
-#> 253:    92.2118   -5.9098   -2.1492   -4.2364   -0.9297    0.2173    0.0340    3.8011    1.0420    2.5338    0.1369    0.2121    1.4074    0.0378    1.0232    0.0731
-#> 254:    92.2107   -5.9104   -2.1479   -4.2362   -0.9296    0.2171    0.0341    3.8085    1.0398    2.5330    0.1366    0.2123    1.4093    0.0377    1.0230    0.0731
-#> 255:    92.2103   -5.9133   -2.1466   -4.2359   -0.9299    0.2166    0.0341    3.8219    1.0381    2.5346    0.1363    0.2122    1.4105    0.0377    1.0230    0.0731
-#> 256:    92.2094   -5.9171   -2.1453   -4.2356   -0.9299    0.2161    0.0341    3.8498    1.0366    2.5366    0.1362    0.2123    1.4114    0.0375    1.0239    0.0731
-#> 257:    92.2091   -5.9169   -2.1441   -4.2353   -0.9302    0.2153    0.0341    3.8529    1.0347    2.5385    0.1360    0.2118    1.4126    0.0375    1.0265    0.0729
-#> 258:    92.2089   -5.9191   -2.1431   -4.2349   -0.9301    0.2145    0.0340    3.8608    1.0331    2.5392    0.1359    0.2119    1.4126    0.0375    1.0282    0.0728
-#> 259:    92.2093   -5.9249   -2.1426   -4.2337   -0.9301    0.2145    0.0341    3.8853    1.0321    2.5385    0.1361    0.2120    1.4114    0.0374    1.0280    0.0728
-#> 260:    92.2095   -5.9297   -2.1415   -4.2328   -0.9303    0.2146    0.0339    3.9108    1.0302    2.5367    0.1358    0.2125    1.4112    0.0373    1.0265    0.0729
-#> 261:    92.2096   -5.9341   -2.1407   -4.2321   -0.9307    0.2147    0.0338    3.9343    1.0278    2.5343    0.1356    0.2131    1.4121    0.0373    1.0272    0.0728
-#> 262:    92.2094   -5.9342   -2.1398   -4.2312   -0.9310    0.2149    0.0336    3.9314    1.0254    2.5313    0.1356    0.2139    1.4115    0.0372    1.0249    0.0729
-#> 263:    92.2088   -5.9376   -2.1388   -4.2304   -0.9313    0.2153    0.0334    3.9452    1.0232    2.5289    0.1357    0.2143    1.4109    0.0371    1.0228    0.0731
-#> 264:    92.2077   -5.9410   -2.1379   -4.2301   -0.9317    0.2153    0.0333    3.9571    1.0204    2.5265    0.1356    0.2147    1.4105    0.0371    1.0224    0.0731
-#> 265:    92.2069   -5.9454   -2.1374   -4.2296   -0.9322    0.2154    0.0332    3.9800    1.0182    2.5230    0.1356    0.2147    1.4115    0.0371    1.0232    0.0730
-#> 266:    92.2067   -5.9463   -2.1370   -4.2291   -0.9324    0.2155    0.0330    3.9809    1.0165    2.5217    0.1354    0.2148    1.4121    0.0371    1.0220    0.0730
-#> 267:    92.2064   -5.9492   -2.1368   -4.2282   -0.9329    0.2154    0.0328    3.9874    1.0150    2.5199    0.1357    0.2150    1.4124    0.0370    1.0233    0.0729
-#> 268:    92.2065   -5.9468   -2.1360   -4.2276   -0.9333    0.2155    0.0328    3.9722    1.0133    2.5171    0.1362    0.2155    1.4133    0.0369    1.0243    0.0729
-#> 269:    92.2066   -5.9438   -2.1352   -4.2267   -0.9335    0.2151    0.0328    3.9526    1.0122    2.5142    0.1367    0.2154    1.4140    0.0369    1.0244    0.0728
-#> 270:    92.2067   -5.9388   -2.1351   -4.2259   -0.9339    0.2151    0.0326    3.9283    1.0112    2.5114    0.1370    0.2157    1.4137    0.0368    1.0240    0.0729
-#> 271:    92.2069   -5.9350   -2.1344   -4.2252   -0.9342    0.2152    0.0324    3.9072    1.0107    2.5094    0.1370    0.2158    1.4136    0.0367    1.0222    0.0730
-#> 272:    92.2069   -5.9317   -2.1341   -4.2246   -0.9348    0.2153    0.0321    3.8870    1.0104    2.5082    0.1372    0.2157    1.4139    0.0366    1.0219    0.0731
-#> 273:    92.2068   -5.9289   -2.1340   -4.2240   -0.9348    0.2152    0.0320    3.8711    1.0101    2.5075    0.1373    0.2159    1.4146    0.0366    1.0232    0.0730
-#> 274:    92.2067   -5.9271   -2.1337   -4.2239   -0.9350    0.2153    0.0318    3.8569    1.0101    2.5085    0.1377    0.2157    1.4144    0.0366    1.0239    0.0731
-#> 275:    92.2063   -5.9264   -2.1339   -4.2235   -0.9353    0.2156    0.0317    3.8476    1.0097    2.5078    0.1382    0.2157    1.4143    0.0365    1.0256    0.0730
-#> 276:    92.2059   -5.9271   -2.1339   -4.2231   -0.9354    0.2160    0.0316    3.8417    1.0097    2.5074    0.1387    0.2156    1.4132    0.0365    1.0260    0.0730
-#> 277:    92.2059   -5.9283   -2.1342   -4.2225   -0.9356    0.2163    0.0316    3.8412    1.0094    2.5073    0.1393    0.2155    1.4122    0.0364    1.0283    0.0729
-#> 278:    92.2062   -5.9278   -2.1341   -4.2220   -0.9361    0.2166    0.0318    3.8331    1.0081    2.5069    0.1397    0.2154    1.4117    0.0364    1.0321    0.0727
-#> 279:    92.2061   -5.9264   -2.1341   -4.2214   -0.9363    0.2168    0.0319    3.8188    1.0072    2.5051    0.1402    0.2155    1.4111    0.0364    1.0342    0.0726
-#> 280:    92.2057   -5.9263   -2.1344   -4.2211   -0.9365    0.2167    0.0321    3.8114    1.0072    2.5061    0.1406    0.2148    1.4108    0.0365    1.0361    0.0725
-#> 281:    92.2048   -5.9269   -2.1344   -4.2208   -0.9365    0.2166    0.0324    3.8082    1.0076    2.5077    0.1410    0.2142    1.4098    0.0365    1.0363    0.0726
-#> 282:    92.2045   -5.9257   -2.1347   -4.2205   -0.9366    0.2165    0.0328    3.8040    1.0082    2.5092    0.1413    0.2138    1.4090    0.0365    1.0364    0.0726
-#> 283:    92.2038   -5.9235   -2.1348   -4.2201   -0.9363    0.2163    0.0331    3.7955    1.0089    2.5108    0.1415    0.2134    1.4086    0.0365    1.0362    0.0726
-#> 284:    92.2032   -5.9234   -2.1348   -4.2198   -0.9359    0.2162    0.0335    3.7945    1.0100    2.5118    0.1420    0.2129    1.4083    0.0365    1.0362    0.0726
-#> 285:    92.2028   -5.9236   -2.1347   -4.2193   -0.9360    0.2161    0.0339    3.7930    1.0104    2.5124    0.1422    0.2125    1.4080    0.0365    1.0373    0.0725
-#> 286:    92.2020   -5.9221   -2.1344   -4.2187   -0.9355    0.2156    0.0341    3.7872    1.0104    2.5134    0.1425    0.2121    1.4074    0.0364    1.0377    0.0725
-#> 287:    92.2013   -5.9213   -2.1341   -4.2183   -0.9354    0.2154    0.0343    3.7888    1.0098    2.5151    0.1428    0.2119    1.4075    0.0364    1.0390    0.0724
-#> 288:    92.2003   -5.9195   -2.1339   -4.2182   -0.9355    0.2152    0.0343    3.7831    1.0090    2.5180    0.1430    0.2116    1.4082    0.0364    1.0408    0.0723
-#> 289:    92.1995   -5.9186   -2.1339   -4.2182   -0.9355    0.2154    0.0343    3.7805    1.0083    2.5217    0.1429    0.2115    1.4085    0.0364    1.0426    0.0722
-#> 290:    92.1984   -5.9180   -2.1339   -4.2177   -0.9354    0.2153    0.0343    3.7767    1.0080    2.5219    0.1427    0.2113    1.4083    0.0365    1.0429    0.0721
-#> 291:    92.1975   -5.9167   -2.1334   -4.2175   -0.9355    0.2151    0.0343    3.7701    1.0080    2.5230    0.1427    0.2108    1.4083    0.0364    1.0439    0.0721
-#> 292:    92.1971   -5.9175   -2.1330   -4.2166   -0.9356    0.2144    0.0342    3.7722    1.0081    2.5227    0.1426    0.2107    1.4079    0.0364    1.0443    0.0721
-#> 293:    92.1963   -5.9188   -2.1330   -4.2157   -0.9357    0.2141    0.0342    3.7768    1.0083    2.5242    0.1425    0.2103    1.4073    0.0364    1.0439    0.0721
-#> 294:    92.1953   -5.9189   -2.1328   -4.2157   -0.9357    0.2136    0.0344    3.7727    1.0078    2.5294    0.1427    0.2095    1.4079    0.0364    1.0456    0.0720
-#> 295:    92.1946   -5.9171   -2.1329   -4.2153   -0.9355    0.2135    0.0345    3.7623    1.0081    2.5331    0.1426    0.2090    1.4080    0.0364    1.0462    0.0720
-#> 296:    92.1940   -5.9154   -2.1329   -4.2150   -0.9354    0.2130    0.0346    3.7523    1.0082    2.5354    0.1425    0.2084    1.4075    0.0365    1.0463    0.0720
-#> 297:    92.1934   -5.9128   -2.1330   -4.2145   -0.9351    0.2127    0.0349    3.7395    1.0084    2.5373    0.1423    0.2079    1.4072    0.0365    1.0453    0.0720
-#> 298:    92.1932   -5.9128   -2.1332   -4.2138   -0.9347    0.2120    0.0350    3.7372    1.0085    2.5368    0.1423    0.2075    1.4068    0.0365    1.0449    0.0720
-#> 299:    92.1927   -5.9120   -2.1333   -4.2131   -0.9344    0.2112    0.0352    3.7324    1.0088    2.5366    0.1422    0.2070    1.4059    0.0366    1.0441    0.0721
-#> 300:    92.1921   -5.9097   -2.1335   -4.2122   -0.9343    0.2105    0.0353    3.7211    1.0096    2.5357    0.1425    0.2066    1.4050    0.0367    1.0443    0.0721
-#> 301:    92.1915   -5.9081   -2.1337   -4.2116   -0.9343    0.2098    0.0355    3.7110    1.0104    2.5355    0.1427    0.2061    1.4041    0.0368    1.0448    0.0721
-#> 302:    92.1912   -5.9067   -2.1340   -4.2108   -0.9342    0.2092    0.0355    3.7052    1.0114    2.5348    0.1428    0.2055    1.4036    0.0369    1.0442    0.0722
-#> 303:    92.1913   -5.9039   -2.1342   -4.2113   -0.9342    0.2087    0.0355    3.6925    1.0123    2.5408    0.1430    0.2049    1.4028    0.0369    1.0436    0.0723
-#> 304:    92.1920   -5.9012   -2.1342   -4.2119   -0.9342    0.2081    0.0356    3.6781    1.0129    2.5476    0.1432    0.2044    1.4026    0.0369    1.0436    0.0723
-#> 305:    92.1923   -5.8984   -2.1343   -4.2123   -0.9341    0.2076    0.0354    3.6633    1.0134    2.5525    0.1434    0.2038    1.4022    0.0370    1.0434    0.0724
-#> 306:    92.1926   -5.8977   -2.1343   -4.2121   -0.9343    0.2072    0.0354    3.6603    1.0144    2.5567    0.1436    0.2030    1.4022    0.0369    1.0431    0.0724
-#> 307:    92.1931   -5.8970   -2.1346   -4.2124   -0.9344    0.2068    0.0353    3.6555    1.0154    2.5617    0.1438    0.2021    1.4017    0.0370    1.0431    0.0725
-#> 308:    92.1935   -5.8963   -2.1347   -4.2127   -0.9343    0.2062    0.0351    3.6486    1.0166    2.5665    0.1439    0.2012    1.4017    0.0370    1.0431    0.0724
-#> 309:    92.1934   -5.8965   -2.1349   -4.2130   -0.9344    0.2058    0.0350    3.6454    1.0180    2.5711    0.1439    0.2003    1.4013    0.0370    1.0427    0.0725
-#> 310:    92.1935   -5.8965   -2.1349   -4.2133   -0.9345    0.2055    0.0350    3.6401    1.0193    2.5761    0.1439    0.1993    1.4013    0.0371    1.0418    0.0725
-#> 311:    92.1931   -5.8976   -2.1349   -4.2139   -0.9346    0.2052    0.0349    3.6416    1.0207    2.5820    0.1437    0.1982    1.4015    0.0370    1.0411    0.0726
-#> 312:    92.1928   -5.8995   -2.1350   -4.2149   -0.9349    0.2053    0.0350    3.6472    1.0222    2.5902    0.1437    0.1972    1.4018    0.0370    1.0412    0.0727
-#> 313:    92.1922   -5.8999   -2.1350   -4.2159   -0.9352    0.2055    0.0350    3.6450    1.0236    2.5989    0.1436    0.1962    1.4017    0.0369    1.0407    0.0728
-#> 314:    92.1913   -5.9021   -2.1353   -4.2171   -0.9353    0.2055    0.0350    3.6532    1.0244    2.6086    0.1437    0.1951    1.4019    0.0369    1.0409    0.0728
-#> 315:    92.1905   -5.9033   -2.1358   -4.2178   -0.9354    0.2055    0.0351    3.6591    1.0252    2.6142    0.1438    0.1941    1.4018    0.0369    1.0420    0.0728
-#> 316:    92.1895   -5.9043   -2.1358   -4.2186   -0.9352    0.2053    0.0352    3.6648    1.0266    2.6207    0.1441    0.1934    1.4016    0.0369    1.0420    0.0729
-#> 317:    92.1888   -5.9041   -2.1359   -4.2200   -0.9352    0.2052    0.0352    3.6673    1.0278    2.6312    0.1444    0.1926    1.4014    0.0369    1.0416    0.0729
-#> 318:    92.1879   -5.9039   -2.1360   -4.2212   -0.9352    0.2052    0.0354    3.6670    1.0292    2.6380    0.1446    0.1919    1.4010    0.0369    1.0403    0.0730
-#> 319:    92.1871   -5.9046   -2.1361   -4.2222   -0.9353    0.2052    0.0354    3.6709    1.0306    2.6432    0.1448    0.1912    1.4008    0.0369    1.0394    0.0731
-#> 320:    92.1863   -5.9023   -2.1365   -4.2229   -0.9355    0.2052    0.0355    3.6602    1.0318    2.6466    0.1448    0.1903    1.4011    0.0369    1.0398    0.0731
-#> 321:    92.1855   -5.8996   -2.1368   -4.2236   -0.9354    0.2053    0.0355    3.6491    1.0329    2.6505    0.1448    0.1895    1.4017    0.0369    1.0402    0.0731
-#> 322:    92.1850   -5.8979   -2.1370   -4.2243   -0.9353    0.2057    0.0356    3.6399    1.0341    2.6534    0.1447    0.1888    1.4020    0.0368    1.0394    0.0732
-#> 323:    92.1844   -5.8984   -2.1371   -4.2251   -0.9352    0.2059    0.0356    3.6431    1.0346    2.6566    0.1447    0.1882    1.4026    0.0368    1.0389    0.0733
-#> 324:    92.1838   -5.8967   -2.1372   -4.2257   -0.9353    0.2062    0.0356    3.6392    1.0351    2.6598    0.1445    0.1875    1.4031    0.0368    1.0382    0.0734
-#> 325:    92.1835   -5.8936   -2.1374   -4.2264   -0.9351    0.2066    0.0355    3.6288    1.0352    2.6633    0.1444    0.1869    1.4043    0.0367    1.0391    0.0734
-#> 326:    92.1837   -5.8936   -2.1376   -4.2276   -0.9350    0.2071    0.0354    3.6296    1.0354    2.6684    0.1444    0.1865    1.4043    0.0367    1.0380    0.0735
-#> 327:    92.1837   -5.8943   -2.1378   -4.2289   -0.9347    0.2076    0.0354    3.6348    1.0357    2.6746    0.1444    0.1860    1.4043    0.0366    1.0380    0.0735
-#> 328:    92.1838   -5.8953   -2.1380   -4.2297   -0.9345    0.2081    0.0354    3.6456    1.0360    2.6776    0.1444    0.1856    1.4043    0.0366    1.0379    0.0735
-#> 329:    92.1836   -5.8974   -2.1383   -4.2305   -0.9342    0.2085    0.0356    3.6591    1.0361    2.6802    0.1444    0.1852    1.4043    0.0366    1.0385    0.0735
-#> 330:    92.1832   -5.8994   -2.1387   -4.2305   -0.9342    0.2088    0.0358    3.6715    1.0364    2.6798    0.1443    0.1849    1.4037    0.0367    1.0378    0.0736
-#> 331:    92.1826   -5.8983   -2.1391   -4.2302   -0.9342    0.2091    0.0357    3.6670    1.0368    2.6800    0.1442    0.1845    1.4038    0.0367    1.0379    0.0736
-#> 332:    92.1824   -5.8959   -2.1396   -4.2301   -0.9341    0.2097    0.0357    3.6576    1.0375    2.6792    0.1442    0.1842    1.4034    0.0367    1.0372    0.0737
-#> 333:    92.1826   -5.8937   -2.1401   -4.2304   -0.9340    0.2104    0.0356    3.6487    1.0383    2.6798    0.1442    0.1838    1.4029    0.0367    1.0360    0.0738
-#> 334:    92.1825   -5.8911   -2.1407   -4.2311   -0.9339    0.2112    0.0355    3.6378    1.0390    2.6825    0.1444    0.1834    1.4025    0.0367    1.0349    0.0739
-#> 335:    92.1830   -5.8887   -2.1411   -4.2317   -0.9336    0.2118    0.0355    3.6294    1.0396    2.6850    0.1444    0.1830    1.4022    0.0367    1.0338    0.0740
-#> 336:    92.1834   -5.8872   -2.1413   -4.2324   -0.9334    0.2124    0.0356    3.6249    1.0402    2.6880    0.1444    0.1825    1.4024    0.0367    1.0339    0.0740
-#> 337:    92.1835   -5.8869   -2.1416   -4.2334   -0.9332    0.2131    0.0356    3.6252    1.0411    2.6926    0.1443    0.1821    1.4029    0.0366    1.0330    0.0741
-#> 338:    92.1839   -5.8882   -2.1418   -4.2346   -0.9333    0.2137    0.0357    3.6332    1.0421    2.6972    0.1441    0.1815    1.4036    0.0366    1.0324    0.0742
-#> 339:    92.1845   -5.8869   -2.1420   -4.2358   -0.9332    0.2143    0.0357    3.6261    1.0428    2.7021    0.1439    0.1810    1.4043    0.0366    1.0322    0.0742
-#> 340:    92.1846   -5.8863   -2.1421   -4.2367   -0.9331    0.2147    0.0357    3.6242    1.0436    2.7060    0.1439    0.1804    1.4049    0.0365    1.0328    0.0743
-#> 341:    92.1848   -5.8847   -2.1421   -4.2378   -0.9330    0.2150    0.0356    3.6177    1.0442    2.7099    0.1439    0.1798    1.4056    0.0366    1.0334    0.0743
-#> 342:    92.1848   -5.8838   -2.1421   -4.2390   -0.9330    0.2154    0.0355    3.6114    1.0449    2.7151    0.1438    0.1792    1.4064    0.0365    1.0332    0.0743
-#> 343:    92.1849   -5.8840   -2.1423   -4.2398   -0.9330    0.2157    0.0353    3.6109    1.0459    2.7191    0.1438    0.1785    1.4060    0.0366    1.0334    0.0743
-#> 344:    92.1851   -5.8839   -2.1423   -4.2406   -0.9330    0.2159    0.0352    3.6092    1.0467    2.7229    0.1440    0.1779    1.4060    0.0365    1.0338    0.0743
-#> 345:    92.1850   -5.8841   -2.1424   -4.2414   -0.9331    0.2162    0.0352    3.6070    1.0472    2.7263    0.1441    0.1774    1.4056    0.0365    1.0341    0.0743
-#> 346:    92.1848   -5.8839   -2.1424   -4.2420   -0.9333    0.2164    0.0352    3.6048    1.0479    2.7292    0.1443    0.1769    1.4058    0.0365    1.0344    0.0743
-#> 347:    92.1846   -5.8835   -2.1425   -4.2427   -0.9334    0.2166    0.0353    3.6017    1.0495    2.7330    0.1444    0.1763    1.4053    0.0365    1.0343    0.0743
-#> 348:    92.1846   -5.8825   -2.1427   -4.2434   -0.9336    0.2168    0.0353    3.5968    1.0508    2.7362    0.1445    0.1757    1.4051    0.0365    1.0343    0.0743
-#> 349:    92.1846   -5.8820   -2.1432   -4.2444   -0.9337    0.2172    0.0352    3.5937    1.0519    2.7412    0.1446    0.1752    1.4047    0.0365    1.0343    0.0743
-#> 350:    92.1845   -5.8817   -2.1435   -4.2454   -0.9338    0.2179    0.0351    3.5899    1.0526    2.7460    0.1448    0.1747    1.4042    0.0365    1.0339    0.0744
-#> 351:    92.1844   -5.8824   -2.1439   -4.2468   -0.9338    0.2184    0.0350    3.5917    1.0535    2.7531    0.1448    0.1740    1.4041    0.0365    1.0336    0.0744
-#> 352:    92.1840   -5.8840   -2.1442   -4.2482   -0.9338    0.2189    0.0350    3.6013    1.0543    2.7603    0.1450    0.1734    1.4044    0.0364    1.0342    0.0744
-#> 353:    92.1838   -5.8848   -2.1445   -4.2492   -0.9336    0.2194    0.0349    3.6030    1.0552    2.7652    0.1451    0.1730    1.4043    0.0364    1.0338    0.0744
-#> 354:    92.1838   -5.8835   -2.1449   -4.2501   -0.9336    0.2197    0.0349    3.5961    1.0563    2.7697    0.1452    0.1723    1.4044    0.0364    1.0342    0.0744
-#> 355:    92.1837   -5.8826   -2.1453   -4.2511   -0.9335    0.2199    0.0348    3.5910    1.0569    2.7757    0.1451    0.1718    1.4053    0.0364    1.0348    0.0744
-#> 356:    92.1835   -5.8826   -2.1456   -4.2520   -0.9334    0.2198    0.0348    3.5922    1.0577    2.7815    0.1451    0.1712    1.4054    0.0364    1.0352    0.0744
-#> 357:    92.1834   -5.8818   -2.1457   -4.2525   -0.9334    0.2198    0.0349    3.5894    1.0588    2.7852    0.1449    0.1706    1.4058    0.0364    1.0354    0.0744
-#> 358:    92.1834   -5.8808   -2.1459   -4.2531   -0.9334    0.2197    0.0348    3.5861    1.0600    2.7891    0.1449    0.1701    1.4062    0.0364    1.0361    0.0744
-#> 359:    92.1833   -5.8799   -2.1459   -4.2533   -0.9333    0.2197    0.0350    3.5822    1.0607    2.7903    0.1448    0.1696    1.4063    0.0364    1.0360    0.0744
-#> 360:    92.1831   -5.8792   -2.1460   -4.2534   -0.9332    0.2196    0.0351    3.5787    1.0613    2.7914    0.1446    0.1691    1.4065    0.0364    1.0361    0.0744
-#> 361:    92.1831   -5.8785   -2.1460   -4.2542   -0.9331    0.2196    0.0351    3.5771    1.0620    2.7969    0.1445    0.1688    1.4072    0.0364    1.0366    0.0744
-#> 362:    92.1832   -5.8780   -2.1462   -4.2547   -0.9331    0.2195    0.0351    3.5750    1.0625    2.8017    0.1443    0.1683    1.4079    0.0363    1.0369    0.0744
-#> 363:    92.1830   -5.8788   -2.1464   -4.2551   -0.9331    0.2192    0.0351    3.5785    1.0630    2.8057    0.1443    0.1677    1.4081    0.0363    1.0377    0.0743
-#> 364:    92.1829   -5.8778   -2.1466   -4.2554   -0.9332    0.2193    0.0350    3.5747    1.0634    2.8092    0.1443    0.1672    1.4084    0.0363    1.0386    0.0743
-#> 365:    92.1830   -5.8782   -2.1466   -4.2558   -0.9332    0.2192    0.0350    3.5771    1.0638    2.8135    0.1443    0.1667    1.4086    0.0363    1.0385    0.0743
-#> 366:    92.1830   -5.8795   -2.1465   -4.2564   -0.9332    0.2190    0.0350    3.5838    1.0645    2.8190    0.1444    0.1661    1.4086    0.0363    1.0390    0.0743
-#> 367:    92.1826   -5.8801   -2.1465   -4.2569   -0.9333    0.2191    0.0349    3.5867    1.0652    2.8232    0.1445    0.1657    1.4086    0.0362    1.0388    0.0744
-#> 368:    92.1824   -5.8799   -2.1465   -4.2571   -0.9333    0.2193    0.0348    3.5859    1.0654    2.8252    0.1445    0.1653    1.4088    0.0362    1.0385    0.0744
-#> 369:    92.1822   -5.8803   -2.1467   -4.2572   -0.9333    0.2193    0.0348    3.5846    1.0653    2.8261    0.1444    0.1648    1.4086    0.0362    1.0393    0.0744
-#> 370:    92.1820   -5.8802   -2.1469   -4.2575   -0.9333    0.2195    0.0348    3.5822    1.0653    2.8273    0.1444    0.1645    1.4088    0.0362    1.0396    0.0744
-#> 371:    92.1818   -5.8806   -2.1470   -4.2575   -0.9333    0.2198    0.0348    3.5819    1.0649    2.8277    0.1443    0.1642    1.4091    0.0362    1.0403    0.0743
-#> 372:    92.1818   -5.8804   -2.1473   -4.2580   -0.9332    0.2202    0.0348    3.5795    1.0645    2.8300    0.1441    0.1640    1.4096    0.0362    1.0418    0.0743
-#> 373:    92.1816   -5.8812   -2.1475   -4.2580   -0.9332    0.2203    0.0348    3.5816    1.0644    2.8298    0.1441    0.1639    1.4100    0.0362    1.0439    0.0741
-#> 374:    92.1815   -5.8817   -2.1477   -4.2578   -0.9333    0.2203    0.0349    3.5819    1.0641    2.8282    0.1440    0.1641    1.4099    0.0362    1.0443    0.0741
-#> 375:    92.1817   -5.8828   -2.1479   -4.2574   -0.9335    0.2204    0.0351    3.5853    1.0636    2.8267    0.1440    0.1642    1.4100    0.0362    1.0457    0.0740
-#> 376:    92.1819   -5.8826   -2.1479   -4.2573   -0.9338    0.2206    0.0353    3.5843    1.0634    2.8246    0.1440    0.1643    1.4100    0.0362    1.0464    0.0740
-#> 377:    92.1819   -5.8826   -2.1480   -4.2572   -0.9339    0.2206    0.0354    3.5819    1.0633    2.8225    0.1440    0.1644    1.4097    0.0363    1.0470    0.0739
-#> 378:    92.1819   -5.8821   -2.1481   -4.2571   -0.9340    0.2205    0.0355    3.5777    1.0633    2.8206    0.1440    0.1644    1.4093    0.0363    1.0468    0.0739
-#> 379:    92.1819   -5.8823   -2.1481   -4.2573   -0.9340    0.2205    0.0356    3.5746    1.0633    2.8201    0.1439    0.1645    1.4092    0.0363    1.0468    0.0739
-#> 380:    92.1820   -5.8809   -2.1481   -4.2570   -0.9340    0.2205    0.0356    3.5665    1.0634    2.8178    0.1439    0.1647    1.4093    0.0363    1.0463    0.0739
-#> 381:    92.1823   -5.8795   -2.1481   -4.2568   -0.9338    0.2204    0.0357    3.5586    1.0635    2.8170    0.1439    0.1648    1.4095    0.0363    1.0456    0.0740
-#> 382:    92.1828   -5.8783   -2.1481   -4.2571   -0.9339    0.2203    0.0357    3.5514    1.0636    2.8183    0.1441    0.1649    1.4093    0.0363    1.0462    0.0740
-#> 383:    92.1827   -5.8773   -2.1480   -4.2569   -0.9340    0.2202    0.0357    3.5459    1.0633    2.8173    0.1441    0.1650    1.4094    0.0363    1.0465    0.0739
-#> 384:    92.1825   -5.8763   -2.1482   -4.2568   -0.9341    0.2202    0.0357    3.5397    1.0636    2.8165    0.1441    0.1650    1.4094    0.0363    1.0467    0.0739
-#> 385:    92.1822   -5.8761   -2.1483   -4.2567   -0.9341    0.2201    0.0357    3.5363    1.0641    2.8160    0.1440    0.1650    1.4094    0.0363    1.0469    0.0739
-#> 386:    92.1820   -5.8763   -2.1485   -4.2567   -0.9342    0.2200    0.0356    3.5365    1.0645    2.8157    0.1441    0.1648    1.4092    0.0364    1.0478    0.0738
-#> 387:    92.1819   -5.8767   -2.1486   -4.2567   -0.9343    0.2201    0.0358    3.5383    1.0652    2.8156    0.1442    0.1646    1.4090    0.0364    1.0480    0.0738
-#> 388:    92.1818   -5.8772   -2.1488   -4.2569   -0.9344    0.2202    0.0359    3.5400    1.0656    2.8153    0.1443    0.1645    1.4086    0.0364    1.0480    0.0738
-#> 389:    92.1816   -5.8765   -2.1489   -4.2569   -0.9344    0.2203    0.0359    3.5369    1.0660    2.8145    0.1443    0.1644    1.4083    0.0364    1.0476    0.0738
-#> 390:    92.1815   -5.8761   -2.1490   -4.2569   -0.9343    0.2205    0.0359    3.5349    1.0664    2.8136    0.1444    0.1644    1.4080    0.0364    1.0472    0.0738
-#> 391:    92.1814   -5.8749   -2.1492   -4.2572   -0.9343    0.2207    0.0359    3.5313    1.0668    2.8153    0.1445    0.1643    1.4077    0.0364    1.0465    0.0739
-#> 392:    92.1812   -5.8733   -2.1494   -4.2571   -0.9344    0.2210    0.0359    3.5248    1.0674    2.8141    0.1445    0.1642    1.4073    0.0364    1.0457    0.0739
-#> 393:    92.1811   -5.8727   -2.1497   -4.2570   -0.9345    0.2212    0.0359    3.5226    1.0679    2.8127    0.1445    0.1642    1.4071    0.0364    1.0457    0.0739
-#> 394:    92.1811   -5.8712   -2.1500   -4.2572   -0.9346    0.2214    0.0360    3.5174    1.0684    2.8132    0.1446    0.1641    1.4067    0.0364    1.0456    0.0739
-#> 395:    92.1810   -5.8714   -2.1501   -4.2579   -0.9348    0.2217    0.0361    3.5182    1.0685    2.8171    0.1445    0.1641    1.4065    0.0364    1.0452    0.0740
-#> 396:    92.1809   -5.8711   -2.1501   -4.2582   -0.9350    0.2220    0.0363    3.5161    1.0681    2.8184    0.1446    0.1639    1.4063    0.0364    1.0447    0.0740
-#> 397:    92.1809   -5.8707   -2.1503   -4.2585   -0.9352    0.2222    0.0363    3.5119    1.0684    2.8197    0.1446    0.1637    1.4065    0.0364    1.0442    0.0740
-#> 398:    92.1808   -5.8703   -2.1503   -4.2591   -0.9354    0.2224    0.0363    3.5084    1.0689    2.8218    0.1447    0.1634    1.4064    0.0364    1.0445    0.0740
-#> 399:    92.1806   -5.8711   -2.1503   -4.2596   -0.9355    0.2226    0.0364    3.5114    1.0691    2.8234    0.1447    0.1629    1.4061    0.0364    1.0447    0.0740
-#> 400:    92.1806   -5.8713   -2.1503   -4.2601   -0.9356    0.2229    0.0366    3.5113    1.0695    2.8253    0.1448    0.1626    1.4059    0.0364    1.0440    0.0740
-#> 401:    92.1804   -5.8709   -2.1503   -4.2604   -0.9357    0.2231    0.0367    3.5089    1.0696    2.8266    0.1448    0.1624    1.4058    0.0364    1.0440    0.0740
-#> 402:    92.1801   -5.8705   -2.1502   -4.2606   -0.9358    0.2232    0.0368    3.5071    1.0695    2.8268    0.1447    0.1621    1.4060    0.0364    1.0447    0.0740
-#> 403:    92.1800   -5.8708   -2.1503   -4.2610   -0.9359    0.2234    0.0369    3.5083    1.0697    2.8271    0.1447    0.1618    1.4056    0.0365    1.0448    0.0739
-#> 404:    92.1798   -5.8709   -2.1505   -4.2612   -0.9360    0.2237    0.0369    3.5085    1.0699    2.8262    0.1447    0.1616    1.4055    0.0365    1.0449    0.0739
-#> 405:    92.1795   -5.8705   -2.1503   -4.2613   -0.9360    0.2239    0.0370    3.5059    1.0698    2.8254    0.1448    0.1615    1.4052    0.0364    1.0449    0.0739
-#> 406:    92.1792   -5.8710   -2.1504   -4.2613   -0.9359    0.2243    0.0371    3.5069    1.0696    2.8244    0.1449    0.1614    1.4049    0.0364    1.0447    0.0739
-#> 407:    92.1788   -5.8718   -2.1505   -4.2614   -0.9359    0.2243    0.0372    3.5092    1.0697    2.8234    0.1449    0.1614    1.4046    0.0364    1.0448    0.0739
-#> 408:    92.1786   -5.8729   -2.1505   -4.2615   -0.9360    0.2245    0.0373    3.5140    1.0699    2.8223    0.1449    0.1612    1.4045    0.0365    1.0455    0.0739
-#> 409:    92.1784   -5.8740   -2.1506   -4.2615   -0.9360    0.2246    0.0373    3.5192    1.0700    2.8213    0.1450    0.1610    1.4042    0.0365    1.0462    0.0738
-#> 410:    92.1782   -5.8753   -2.1505   -4.2616   -0.9361    0.2246    0.0373    3.5248    1.0705    2.8205    0.1450    0.1607    1.4040    0.0365    1.0465    0.0738
-#> 411:    92.1780   -5.8758   -2.1503   -4.2619   -0.9362    0.2247    0.0374    3.5249    1.0707    2.8204    0.1449    0.1605    1.4043    0.0364    1.0467    0.0738
-#> 412:    92.1778   -5.8759   -2.1502   -4.2621   -0.9363    0.2248    0.0374    3.5238    1.0707    2.8209    0.1448    0.1602    1.4045    0.0364    1.0466    0.0738
-#> 413:    92.1779   -5.8759   -2.1501   -4.2623   -0.9364    0.2249    0.0374    3.5225    1.0711    2.8213    0.1448    0.1600    1.4043    0.0364    1.0460    0.0738
-#> 414:    92.1781   -5.8754   -2.1500   -4.2622   -0.9364    0.2250    0.0374    3.5205    1.0710    2.8203    0.1448    0.1599    1.4047    0.0364    1.0456    0.0738
-#> 415:    92.1781   -5.8750   -2.1499   -4.2623   -0.9363    0.2251    0.0374    3.5187    1.0709    2.8190    0.1448    0.1598    1.4050    0.0364    1.0448    0.0738
-#> 416:    92.1783   -5.8747   -2.1500   -4.2624   -0.9363    0.2252    0.0375    3.5216    1.0708    2.8187    0.1448    0.1598    1.4052    0.0364    1.0440    0.0738
-#> 417:    92.1783   -5.8738   -2.1500   -4.2625   -0.9362    0.2252    0.0375    3.5219    1.0712    2.8188    0.1447    0.1597    1.4055    0.0364    1.0438    0.0739
-#> 418:    92.1784   -5.8735   -2.1501   -4.2627   -0.9360    0.2254    0.0375    3.5222    1.0715    2.8193    0.1448    0.1596    1.4057    0.0364    1.0438    0.0739
-#> 419:    92.1784   -5.8725   -2.1501   -4.2629   -0.9358    0.2255    0.0376    3.5190    1.0719    2.8202    0.1447    0.1594    1.4060    0.0364    1.0436    0.0739
-#> 420:    92.1785   -5.8713   -2.1500   -4.2633   -0.9357    0.2256    0.0377    3.5152    1.0723    2.8213    0.1447    0.1592    1.4065    0.0364    1.0439    0.0738
-#> 421:    92.1786   -5.8697   -2.1500   -4.2639   -0.9355    0.2257    0.0377    3.5100    1.0728    2.8232    0.1448    0.1592    1.4068    0.0364    1.0436    0.0739
-#> 422:    92.1787   -5.8683   -2.1502   -4.2645   -0.9352    0.2260    0.0377    3.5051    1.0732    2.8258    0.1448    0.1592    1.4069    0.0364    1.0432    0.0739
-#> 423:    92.1788   -5.8667   -2.1504   -4.2653   -0.9350    0.2262    0.0377    3.4992    1.0736    2.8292    0.1448    0.1592    1.4071    0.0364    1.0435    0.0738
-#> 424:    92.1789   -5.8659   -2.1505   -4.2661   -0.9349    0.2263    0.0378    3.4972    1.0739    2.8324    0.1448    0.1591    1.4069    0.0364    1.0439    0.0738
-#> 425:    92.1788   -5.8649   -2.1505   -4.2669   -0.9349    0.2263    0.0378    3.4947    1.0740    2.8358    0.1448    0.1590    1.4071    0.0364    1.0438    0.0738
-#> 426:    92.1788   -5.8643   -2.1506   -4.2677   -0.9348    0.2265    0.0377    3.4922    1.0743    2.8389    0.1448    0.1589    1.4070    0.0365    1.0437    0.0738
-#> 427:    92.1785   -5.8637   -2.1506   -4.2683   -0.9347    0.2266    0.0378    3.4895    1.0747    2.8425    0.1448    0.1588    1.4068    0.0365    1.0434    0.0738
-#> 428:    92.1783   -5.8627   -2.1507   -4.2689   -0.9347    0.2268    0.0378    3.4870    1.0749    2.8464    0.1447    0.1586    1.4070    0.0365    1.0434    0.0738
-#> 429:    92.1782   -5.8617   -2.1509   -4.2696   -0.9347    0.2271    0.0379    3.4845    1.0752    2.8500    0.1446    0.1584    1.4072    0.0365    1.0439    0.0738
-#> 430:    92.1783   -5.8608   -2.1510   -4.2701   -0.9347    0.2274    0.0379    3.4830    1.0755    2.8526    0.1446    0.1582    1.4075    0.0365    1.0443    0.0738
-#> 431:    92.1784   -5.8606   -2.1511   -4.2704   -0.9348    0.2275    0.0379    3.4825    1.0757    2.8532    0.1446    0.1580    1.4076    0.0365    1.0439    0.0738
-#> 432:    92.1784   -5.8610   -2.1512   -4.2707   -0.9350    0.2275    0.0378    3.4833    1.0761    2.8539    0.1447    0.1578    1.4079    0.0365    1.0443    0.0738
-#> 433:    92.1783   -5.8618   -2.1512   -4.2711   -0.9351    0.2276    0.0378    3.4867    1.0768    2.8554    0.1447    0.1577    1.4078    0.0366    1.0440    0.0738
-#> 434:    92.1784   -5.8612   -2.1513   -4.2714   -0.9350    0.2278    0.0378    3.4858    1.0774    2.8564    0.1448    0.1577    1.4074    0.0365    1.0430    0.0739
-#> 435:    92.1783   -5.8610   -2.1513   -4.2718   -0.9348    0.2279    0.0377    3.4874    1.0779    2.8581    0.1448    0.1576    1.4072    0.0366    1.0423    0.0739
-#> 436:    92.1781   -5.8610   -2.1513   -4.2721   -0.9346    0.2280    0.0376    3.4879    1.0789    2.8598    0.1448    0.1575    1.4070    0.0365    1.0417    0.0739
-#> 437:    92.1781   -5.8610   -2.1511   -4.2726   -0.9345    0.2279    0.0376    3.4886    1.0794    2.8618    0.1449    0.1574    1.4071    0.0365    1.0417    0.0739
-#> 438:    92.1781   -5.8609   -2.1510   -4.2730   -0.9345    0.2280    0.0375    3.4893    1.0797    2.8641    0.1449    0.1573    1.4075    0.0365    1.0420    0.0739
-#> 439:    92.1781   -5.8608   -2.1509   -4.2734   -0.9343    0.2280    0.0374    3.4894    1.0803    2.8659    0.1449    0.1573    1.4076    0.0365    1.0421    0.0739
-#> 440:    92.1780   -5.8603   -2.1510   -4.2737   -0.9343    0.2279    0.0374    3.4885    1.0808    2.8674    0.1448    0.1573    1.4079    0.0365    1.0430    0.0738
-#> 441:    92.1779   -5.8600   -2.1510   -4.2738   -0.9342    0.2279    0.0373    3.4899    1.0811    2.8686    0.1447    0.1574    1.4086    0.0365    1.0445    0.0737
-#> 442:    92.1779   -5.8600   -2.1509   -4.2737   -0.9343    0.2278    0.0372    3.4925    1.0814    2.8691    0.1447    0.1575    1.4088    0.0365    1.0451    0.0737
-#> 443:    92.1780   -5.8598   -2.1509   -4.2739   -0.9341    0.2278    0.0372    3.4949    1.0819    2.8705    0.1447    0.1576    1.4092    0.0365    1.0453    0.0737
-#> 444:    92.1779   -5.8593   -2.1510   -4.2742   -0.9340    0.2277    0.0371    3.4951    1.0824    2.8717    0.1447    0.1576    1.4096    0.0365    1.0455    0.0737
-#> 445:    92.1777   -5.8593   -2.1511   -4.2744   -0.9338    0.2275    0.0371    3.4999    1.0828    2.8729    0.1448    0.1576    1.4100    0.0365    1.0461    0.0736
-#> 446:    92.1774   -5.8600   -2.1511   -4.2748   -0.9338    0.2274    0.0372    3.5051    1.0837    2.8747    0.1449    0.1576    1.4099    0.0365    1.0464    0.0736
-#> 447:    92.1771   -5.8604   -2.1512   -4.2751   -0.9338    0.2273    0.0373    3.5087    1.0844    2.8758    0.1449    0.1575    1.4097    0.0365    1.0467    0.0736
-#> 448:    92.1769   -5.8607   -2.1513   -4.2756   -0.9336    0.2272    0.0374    3.5124    1.0849    2.8778    0.1449    0.1575    1.4098    0.0365    1.0470    0.0735
-#> 449:    92.1768   -5.8611   -2.1515   -4.2759   -0.9337    0.2270    0.0374    3.5165    1.0853    2.8789    0.1449    0.1575    1.4101    0.0365    1.0473    0.0735
-#> 450:    92.1766   -5.8611   -2.1515   -4.2762   -0.9337    0.2269    0.0374    3.5158    1.0859    2.8800    0.1448    0.1576    1.4102    0.0365    1.0474    0.0735
-#> 451:    92.1762   -5.8615   -2.1514   -4.2765   -0.9337    0.2267    0.0374    3.5202    1.0866    2.8812    0.1447    0.1576    1.4104    0.0365    1.0477    0.0735
-#> 452:    92.1761   -5.8622   -2.1514   -4.2767   -0.9337    0.2264    0.0374    3.5232    1.0871    2.8824    0.1447    0.1576    1.4103    0.0365    1.0479    0.0734
-#> 453:    92.1760   -5.8621   -2.1514   -4.2776   -0.9336    0.2261    0.0373    3.5247    1.0878    2.8901    0.1447    0.1576    1.4103    0.0365    1.0480    0.0734
-#> 454:    92.1759   -5.8611   -2.1513   -4.2781   -0.9335    0.2259    0.0373    3.5206    1.0882    2.8939    0.1448    0.1575    1.4104    0.0365    1.0483    0.0734
-#> 455:    92.1758   -5.8599   -2.1513   -4.2788   -0.9336    0.2258    0.0372    3.5151    1.0887    2.9010    0.1448    0.1575    1.4104    0.0365    1.0485    0.0734
-#> 456:    92.1760   -5.8583   -2.1512   -4.2797   -0.9335    0.2258    0.0372    3.5086    1.0892    2.9081    0.1448    0.1574    1.4105    0.0365    1.0483    0.0734
-#> 457:    92.1761   -5.8575   -2.1513   -4.2804   -0.9334    0.2257    0.0371    3.5041    1.0896    2.9144    0.1449    0.1574    1.4103    0.0365    1.0480    0.0733
-#> 458:    92.1763   -5.8569   -2.1512   -4.2813   -0.9334    0.2257    0.0370    3.5014    1.0901    2.9227    0.1449    0.1574    1.4102    0.0365    1.0476    0.0734
-#> 459:    92.1763   -5.8565   -2.1512   -4.2816   -0.9334    0.2256    0.0370    3.4991    1.0908    2.9248    0.1449    0.1573    1.4100    0.0365    1.0471    0.0734
-#> 460:    92.1764   -5.8557   -2.1513   -4.2818   -0.9333    0.2256    0.0370    3.4957    1.0915    2.9258    0.1449    0.1572    1.4097    0.0365    1.0466    0.0734
-#> 461:    92.1765   -5.8550   -2.1515   -4.2822   -0.9333    0.2255    0.0370    3.4923    1.0921    2.9296    0.1449    0.1571    1.4097    0.0365    1.0464    0.0734
-#> 462:    92.1764   -5.8546   -2.1517   -4.2824   -0.9333    0.2256    0.0370    3.4897    1.0925    2.9319    0.1448    0.1569    1.4093    0.0365    1.0463    0.0733
-#> 463:    92.1763   -5.8539   -2.1519   -4.2830   -0.9333    0.2256    0.0369    3.4863    1.0928    2.9373    0.1449    0.1568    1.4093    0.0366    1.0463    0.0733
-#> 464:    92.1763   -5.8532   -2.1520   -4.2833   -0.9333    0.2257    0.0370    3.4825    1.0933    2.9405    0.1448    0.1567    1.4093    0.0366    1.0462    0.0733
-#> 465:    92.1762   -5.8528   -2.1521   -4.2837   -0.9335    0.2257    0.0370    3.4795    1.0938    2.9433    0.1448    0.1567    1.4093    0.0366    1.0464    0.0733
-#> 466:    92.1762   -5.8530   -2.1523   -4.2840   -0.9336    0.2256    0.0370    3.4780    1.0943    2.9462    0.1448    0.1566    1.4089    0.0366    1.0466    0.0733
-#> 467:    92.1764   -5.8529   -2.1524   -4.2846   -0.9337    0.2256    0.0371    3.4751    1.0948    2.9506    0.1447    0.1565    1.4087    0.0366    1.0465    0.0733
-#> 468:    92.1765   -5.8531   -2.1525   -4.2849   -0.9337    0.2255    0.0371    3.4734    1.0952    2.9523    0.1447    0.1563    1.4087    0.0366    1.0465    0.0733
-#> 469:    92.1767   -5.8533   -2.1525   -4.2853   -0.9337    0.2254    0.0372    3.4754    1.0958    2.9540    0.1447    0.1561    1.4090    0.0366    1.0472    0.0733
-#> 470:    92.1767   -5.8536   -2.1525   -4.2858   -0.9338    0.2254    0.0373    3.4780    1.0965    2.9571    0.1448    0.1559    1.4094    0.0366    1.0478    0.0732
-#> 471:    92.1767   -5.8540   -2.1525   -4.2864   -0.9338    0.2254    0.0373    3.4812    1.0970    2.9606    0.1447    0.1558    1.4099    0.0366    1.0482    0.0732
-#> 472:    92.1766   -5.8547   -2.1526   -4.2871   -0.9339    0.2255    0.0373    3.4844    1.0975    2.9645    0.1446    0.1556    1.4101    0.0366    1.0482    0.0732
-#> 473:    92.1764   -5.8549   -2.1527   -4.2875   -0.9339    0.2255    0.0373    3.4848    1.0977    2.9672    0.1446    0.1554    1.4100    0.0366    1.0482    0.0732
-#> 474:    92.1762   -5.8553   -2.1528   -4.2880   -0.9338    0.2256    0.0373    3.4855    1.0979    2.9700    0.1445    0.1552    1.4104    0.0366    1.0484    0.0732
-#> 475:    92.1763   -5.8561   -2.1530   -4.2884   -0.9338    0.2256    0.0374    3.4885    1.0981    2.9726    0.1445    0.1549    1.4103    0.0366    1.0484    0.0731
-#> 476:    92.1763   -5.8564   -2.1530   -4.2885   -0.9339    0.2258    0.0374    3.4914    1.0983    2.9734    0.1444    0.1548    1.4106    0.0366    1.0484    0.0731
-#> 477:    92.1763   -5.8565   -2.1531   -4.2888   -0.9340    0.2259    0.0373    3.4941    1.0985    2.9755    0.1443    0.1546    1.4108    0.0366    1.0487    0.0731
-#> 478:    92.1763   -5.8576   -2.1532   -4.2889   -0.9340    0.2258    0.0373    3.4995    1.0987    2.9772    0.1442    0.1544    1.4111    0.0366    1.0490    0.0731
-#> 479:    92.1765   -5.8593   -2.1533   -4.2890   -0.9342    0.2259    0.0372    3.5086    1.0990    2.9787    0.1442    0.1544    1.4113    0.0366    1.0495    0.0731
-#> 480:    92.1766   -5.8613   -2.1535   -4.2892   -0.9342    0.2260    0.0372    3.5233    1.0991    2.9800    0.1442    0.1543    1.4116    0.0367    1.0496    0.0730
-#> 481:    92.1768   -5.8624   -2.1536   -4.2894   -0.9341    0.2260    0.0371    3.5309    1.0993    2.9820    0.1442    0.1542    1.4117    0.0367    1.0497    0.0730
-#> 482:    92.1766   -5.8634   -2.1537   -4.2896   -0.9341    0.2260    0.0371    3.5393    1.0995    2.9833    0.1443    0.1542    1.4116    0.0367    1.0496    0.0730
-#> 483:    92.1762   -5.8645   -2.1538   -4.2896   -0.9340    0.2260    0.0372    3.5472    1.0997    2.9840    0.1443    0.1542    1.4115    0.0367    1.0498    0.0730
-#> 484:    92.1757   -5.8648   -2.1538   -4.2896   -0.9340    0.2261    0.0373    3.5508    1.0998    2.9843    0.1445    0.1542    1.4115    0.0366    1.0498    0.0730
-#> 485:    92.1752   -5.8648   -2.1539   -4.2896   -0.9340    0.2262    0.0374    3.5516    1.1000    2.9846    0.1445    0.1542    1.4115    0.0366    1.0497    0.0730
-#> 486:    92.1747   -5.8649   -2.1539   -4.2897   -0.9340    0.2262    0.0375    3.5517    1.1003    2.9856    0.1446    0.1541    1.4113    0.0366    1.0498    0.0730
-#> 487:    92.1743   -5.8649   -2.1539   -4.2896   -0.9340    0.2262    0.0376    3.5502    1.1006    2.9856    0.1447    0.1539    1.4110    0.0367    1.0498    0.0730
-#> 488:    92.1739   -5.8645   -2.1540   -4.2893   -0.9340    0.2261    0.0377    3.5475    1.1008    2.9848    0.1447    0.1537    1.4106    0.0367    1.0497    0.0729
-#> 489:    92.1736   -5.8640   -2.1539   -4.2892   -0.9340    0.2260    0.0376    3.5445    1.1011    2.9844    0.1448    0.1536    1.4105    0.0367    1.0496    0.0729
-#> 490:    92.1736   -5.8631   -2.1539   -4.2889   -0.9340    0.2260    0.0376    3.5402    1.1014    2.9835    0.1448    0.1534    1.4103    0.0366    1.0496    0.0729
-#> 491:    92.1735   -5.8617   -2.1539   -4.2887   -0.9339    0.2260    0.0375    3.5343    1.1016    2.9825    0.1449    0.1532    1.4103    0.0366    1.0497    0.0729
-#> 492:    92.1736   -5.8609   -2.1539   -4.2884   -0.9339    0.2259    0.0375    3.5298    1.1017    2.9816    0.1449    0.1530    1.4101    0.0367    1.0499    0.0729
-#> 493:    92.1737   -5.8605   -2.1539   -4.2882   -0.9339    0.2260    0.0375    3.5266    1.1018    2.9807    0.1450    0.1529    1.4098    0.0367    1.0496    0.0729
-#> 494:    92.1739   -5.8609   -2.1539   -4.2881   -0.9340    0.2261    0.0375    3.5273    1.1018    2.9802    0.1450    0.1528    1.4097    0.0367    1.0495    0.0729
-#> 495:    92.1741   -5.8614   -2.1540   -4.2880   -0.9340    0.2262    0.0376    3.5290    1.1019    2.9797    0.1450    0.1526    1.4096    0.0367    1.0492    0.0729
-#> 496:    92.1742   -5.8623   -2.1540   -4.2879   -0.9341    0.2262    0.0376    3.5348    1.1020    2.9791    0.1449    0.1525    1.4096    0.0367    1.0491    0.0729
-#> 497:    92.1742   -5.8634   -2.1541   -4.2879   -0.9341    0.2264    0.0377    3.5402    1.1020    2.9789    0.1449    0.1524    1.4097    0.0367    1.0493    0.0729
-#> 498:    92.1744   -5.8637   -2.1543   -4.2879   -0.9341    0.2266    0.0377    3.5406    1.1019    2.9787    0.1449    0.1524    1.4096    0.0367    1.0496    0.0729
-#> 499:    92.1744   -5.8635   -2.1544   -4.2880   -0.9341    0.2268    0.0376    3.5400    1.1019    2.9789    0.1450    0.1523    1.4095    0.0367    1.0500    0.0728
-#> 500:    92.1744   -5.8628   -2.1545   -4.2882   -0.9341    0.2270    0.0377    3.5381    1.1020    2.9795    0.1450    0.1522    1.4096    0.0367    1.0503    0.0728
-#> Calculating covariance matrix
-#> 
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Calculating residuals/tables
-#> done
-f_nlmixr_dfop_sfo_focei_obs_tc <- nlmixr(f_mmkin_tc["DFOP-SFO", ], est = "focei",
-  error_model = "obs_tc")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
-#> F: Forward difference gradient approximation
-#> C: Central difference gradient approximation
-#> M: Mixed forward and central difference gradient approximation
-#> Unscaled parameters for Omegas=chol(solve(omega));
-#> Diagonals are transformed, as specified by foceiControl(diagXform=)
-#> |-----+---------------+-----------+-----------+-----------+-----------|
-#> |    #| Objective Fun |  parent_0 |  log_k_A1 |f_parent_qlogis |    log_k1 |
-#> |.....................|    log_k2 |  g_qlogis |sigma_low_parent |rsd_high_parent |
-#> |.....................|sigma_low_A1 |rsd_high_A1 |        o1 |        o2 |
-#> |.....................|        o3 |        o4 |        o5 |        o6 |
-#> |    1|     495.48573 |     1.000 |    -1.000 |   -0.9104 |   -0.9376 |
-#> |.....................|   -0.9875 |   -0.8823 |   -0.8746 |   -0.8907 |
-#> |.....................|   -0.8746 |   -0.8907 |   -0.8767 |   -0.8731 |
-#> |.....................|   -0.8673 |   -0.8720 |   -0.8739 |   -0.8666 |
-#> |    U|     495.48573 |     91.00 |    -5.200 |   -0.8900 |    -2.200 |
-#> |.....................|    -4.600 |    0.4600 |    0.8300 |   0.05800 |
-#> |.....................|    0.8300 |   0.05800 |    0.7311 |    0.9036 |
-#> |.....................|     1.183 |    0.9554 |    0.8633 |     1.214 |
-#> |    X|     495.48573 |     91.00 |  0.005517 |    0.2911 |    0.1108 |
-#> |.....................|   0.01005 |    0.6130 |    0.8300 |   0.05800 |
-#> |.....................|    0.8300 |   0.05800 |    0.7311 |    0.9036 |
-#> |.....................|     1.183 |    0.9554 |    0.8633 |     1.214 |
-#> |    G|    Gill Diff. |   -0.9648 |     2.223 |   -0.3153 |  -0.01817 |
-#> |.....................|   -0.3350 |    0.6789 |    -23.42 |    -17.64 |
-#> |.....................|    -5.440 |    -1.950 |    0.9642 |     9.851 |
-#> |.....................|    -11.94 |    -1.319 |     8.578 |    -12.45 |
-#> |    2|     481.75012 |     1.026 |    -1.060 |   -0.9019 |   -0.9371 |
-#> |.....................|   -0.9785 |   -0.9007 |   -0.2420 |   -0.4142 |
-#> |.....................|   -0.7277 |   -0.8380 |   -0.9027 |    -1.139 |
-#> |.....................|   -0.5448 |   -0.8364 |    -1.106 |   -0.5303 |
-#> |    U|     481.75012 |     93.37 |    -5.260 |   -0.8824 |    -2.200 |
-#> |.....................|    -4.591 |    0.4516 |     1.093 |   0.07182 |
-#> |.....................|    0.8910 |   0.05953 |    0.7121 |    0.6631 |
-#> |.....................|     1.565 |    0.9895 |    0.6633 |     1.623 |
-#> |    X|     481.75012 |     93.37 |  0.005195 |    0.2927 |    0.1109 |
-#> |.....................|   0.01014 |    0.6110 |     1.093 |   0.07182 |
-#> |.....................|    0.8910 |   0.05953 |    0.7121 |    0.6631 |
-#> |.....................|     1.565 |    0.9895 |    0.6633 |     1.623 |
-#> |    F| Forward Diff. |     152.5 |     1.317 |     3.315 |   -0.1772 |
-#> |.....................|    0.3391 |    0.1426 |    -4.513 |     6.696 |
-#> |.....................|     1.211 |    0.7988 |    0.6299 |    -5.324 |
-#> |.....................|  0.009964 |     3.044 |    -5.727 |    -6.694 |
-#> |    3|     3004.9713 |    0.2745 |    -1.093 |   -0.9147 |   -0.9360 |
-#> |.....................|   -0.9762 |   -0.9095 |   0.05941 |   -0.2377 |
-#> |.....................|   -0.6690 |   -0.8188 |   -0.9174 |    -1.204 |
-#> |.....................|   -0.4027 |   -0.8359 |    -1.205 |   -0.3486 |
-#> |    U|     3004.9713 |     24.98 |    -5.293 |   -0.8938 |    -2.198 |
-#> |.....................|    -4.589 |    0.4475 |     1.218 |   0.07694 |
-#> |.....................|    0.9154 |   0.06008 |    0.7014 |    0.6043 |
-#> |.....................|     1.733 |    0.9899 |    0.5774 |     1.843 |
-#> |    X|     3004.9713 |     24.98 |  0.005026 |    0.2903 |    0.1110 |
-#> |.....................|   0.01017 |    0.6100 |     1.218 |   0.07694 |
-#> |.....................|    0.9154 |   0.06008 |    0.7014 |    0.6043 |
-#> |.....................|     1.733 |    0.9899 |    0.5774 |     1.843 |
-#> |    4|     491.68825 |    0.9393 |    -1.061 |   -0.9038 |   -0.9370 |
-#> |.....................|   -0.9787 |   -0.9008 |   -0.2394 |   -0.4180 |
-#> |.....................|   -0.7284 |   -0.8385 |   -0.9031 |    -1.136 |
-#> |.....................|   -0.5448 |   -0.8381 |    -1.102 |   -0.5265 |
-#> |    U|     491.68825 |     85.47 |    -5.261 |   -0.8841 |    -2.199 |
-#> |.....................|    -4.591 |    0.4515 |     1.094 |   0.07171 |
-#> |.....................|    0.8907 |   0.05951 |    0.7118 |    0.6659 |
-#> |.....................|     1.565 |    0.9878 |    0.6661 |     1.627 |
-#> |    X|     491.68825 |     85.47 |  0.005191 |    0.2923 |    0.1109 |
-#> |.....................|   0.01014 |    0.6110 |     1.094 |   0.07171 |
-#> |.....................|    0.8907 |   0.05951 |    0.7118 |    0.6659 |
-#> |.....................|     1.565 |    0.9878 |    0.6661 |     1.627 |
-#> |    5|     479.72282 |     1.001 |    -1.060 |   -0.9024 |   -0.9371 |
-#> |.....................|   -0.9785 |   -0.9007 |   -0.2413 |   -0.4153 |
-#> |.....................|   -0.7279 |   -0.8381 |   -0.9028 |    -1.138 |
-#> |.....................|   -0.5448 |   -0.8369 |    -1.105 |   -0.5292 |
-#> |    U|     479.72282 |     91.11 |    -5.260 |   -0.8829 |    -2.199 |
-#> |.....................|    -4.591 |    0.4516 |     1.093 |   0.07179 |
-#> |.....................|    0.8909 |   0.05952 |    0.7120 |    0.6639 |
-#> |.....................|     1.565 |    0.9890 |    0.6641 |     1.624 |
-#> |    X|     479.72282 |     91.11 |  0.005194 |    0.2926 |    0.1109 |
-#> |.....................|   0.01014 |    0.6110 |     1.093 |   0.07179 |
-#> |.....................|    0.8909 |   0.05952 |    0.7120 |    0.6639 |
-#> |.....................|     1.565 |    0.9890 |    0.6641 |     1.624 |
-#> |    F| Forward Diff. |     6.589 |     1.222 |    0.9137 |    0.1103 |
-#> |.....................|    0.3993 |    0.5206 |    -3.904 |     6.654 |
-#> |.....................|    0.9090 |     1.134 |    -1.839 |    -6.108 |
-#> |.....................|     1.622 |     4.007 |    -4.921 |    -6.374 |
-#> |    6|     479.56384 |    0.9950 |    -1.061 |   -0.9037 |   -0.9373 |
-#> |.....................|   -0.9792 |   -0.9012 |   -0.2438 |   -0.4298 |
-#> |.....................|   -0.7309 |   -0.8403 |   -0.9001 |    -1.126 |
-#> |.....................|   -0.5509 |   -0.8426 |    -1.095 |   -0.5241 |
-#> |    U|     479.56384 |     90.55 |    -5.261 |   -0.8840 |    -2.200 |
-#> |.....................|    -4.592 |    0.4513 |     1.092 |   0.07137 |
-#> |.....................|    0.8897 |   0.05946 |    0.7140 |    0.6748 |
-#> |.....................|     1.558 |    0.9836 |    0.6729 |     1.630 |
-#> |    X|     479.56384 |     90.55 |  0.005189 |    0.2923 |    0.1108 |
-#> |.....................|   0.01014 |    0.6110 |     1.092 |   0.07137 |
-#> |.....................|    0.8897 |   0.05946 |    0.7140 |    0.6748 |
-#> |.....................|     1.558 |    0.9836 |    0.6729 |     1.630 |
-#> |    F| Forward Diff. |    -31.71 |     1.225 |    0.1963 |    0.1681 |
-#> |.....................|    0.4113 |    0.6853 |    -4.208 |     6.141 |
-#> |.....................|    0.7033 |     1.163 |    -2.029 |    -4.071 |
-#> |.....................|    -1.106 |     3.494 |    -3.921 |    -6.098 |
-#> |    7|     479.23599 |     1.003 |    -1.063 |   -0.9048 |   -0.9375 |
-#> |.....................|   -0.9799 |   -0.9023 |   -0.2352 |   -0.4403 |
-#> |.....................|   -0.7320 |   -0.8422 |   -0.8974 |    -1.117 |
-#> |.....................|   -0.5472 |   -0.8484 |    -1.086 |   -0.5115 |
-#> |    U|     479.23599 |     91.29 |    -5.263 |   -0.8850 |    -2.200 |
-#> |.....................|    -4.592 |    0.4508 |     1.095 |   0.07106 |
-#> |.....................|    0.8892 |   0.05941 |    0.7160 |    0.6828 |
-#> |.....................|     1.562 |    0.9781 |    0.6800 |     1.645 |
-#> |    X|     479.23599 |     91.29 |  0.005177 |    0.2921 |    0.1108 |
-#> |.....................|   0.01013 |    0.6108 |     1.095 |   0.07106 |
-#> |.....................|    0.8892 |   0.05941 |    0.7160 |    0.6828 |
-#> |.....................|     1.562 |    0.9781 |    0.6800 |     1.645 |
-#> |    F| Forward Diff. |     18.36 |     1.286 |    0.8956 |   0.06941 |
-#> |.....................|    0.3942 |    0.6495 |    -3.460 |     6.349 |
-#> |.....................|    0.7828 |    0.9998 |    -1.947 |    -2.931 |
-#> |.....................|    0.1591 |     2.144 |    -3.375 |    -5.909 |
-#> |    8|     479.05200 |    0.9982 |    -1.066 |   -0.9056 |   -0.9376 |
-#> |.....................|   -0.9803 |   -0.9037 |   -0.2181 |   -0.4407 |
-#> |.....................|   -0.7304 |   -0.8427 |   -0.8951 |    -1.119 |
-#> |.....................|   -0.5384 |   -0.8504 |    -1.087 |   -0.4972 |
-#> |    U|       479.052 |     90.84 |    -5.266 |   -0.8857 |    -2.200 |
-#> |.....................|    -4.593 |    0.4502 |     1.102 |   0.07105 |
-#> |.....................|    0.8899 |   0.05939 |    0.7177 |    0.6818 |
-#> |.....................|     1.572 |    0.9761 |    0.6797 |     1.663 |
-#> |    X|       479.052 |     90.84 |  0.005162 |    0.2920 |    0.1108 |
-#> |.....................|   0.01012 |    0.6107 |     1.102 |   0.07105 |
-#> |.....................|    0.8899 |   0.05939 |    0.7177 |    0.6818 |
-#> |.....................|     1.572 |    0.9761 |    0.6797 |     1.663 |
-#> |    9|     478.91507 |    0.9977 |    -1.070 |   -0.9061 |   -0.9377 |
-#> |.....................|   -0.9807 |   -0.9051 |   -0.2002 |   -0.4395 |
-#> |.....................|   -0.7284 |   -0.8431 |   -0.8930 |    -1.121 |
-#> |.....................|   -0.5287 |   -0.8520 |    -1.088 |   -0.4828 |
-#> |    U|     478.91507 |     90.79 |    -5.270 |   -0.8862 |    -2.200 |
-#> |.....................|    -4.593 |    0.4495 |     1.110 |   0.07109 |
-#> |.....................|    0.8907 |   0.05938 |    0.7192 |    0.6799 |
-#> |.....................|     1.584 |    0.9745 |    0.6785 |     1.680 |
-#> |    X|     478.91507 |     90.79 |  0.005146 |    0.2919 |    0.1108 |
-#> |.....................|   0.01012 |    0.6105 |     1.110 |   0.07109 |
-#> |.....................|    0.8907 |   0.05938 |    0.7192 |    0.6799 |
-#> |.....................|     1.584 |    0.9745 |    0.6785 |     1.680 |
-#> |   10|     478.54700 |    0.9959 |    -1.080 |   -0.9081 |   -0.9381 |
-#> |.....................|   -0.9820 |   -0.9099 |   -0.1391 |   -0.4353 |
-#> |.....................|   -0.7215 |   -0.8442 |   -0.8862 |    -1.128 |
-#> |.....................|   -0.4957 |   -0.8577 |    -1.093 |   -0.4342 |
-#> |    U|       478.547 |     90.63 |    -5.280 |   -0.8880 |    -2.200 |
-#> |.....................|    -4.594 |    0.4473 |     1.135 |   0.07121 |
-#> |.....................|    0.8936 |   0.05935 |    0.7242 |    0.6734 |
-#> |.....................|     1.623 |    0.9691 |    0.6746 |     1.739 |
-#> |    X|       478.547 |     90.63 |  0.005094 |    0.2915 |    0.1108 |
-#> |.....................|   0.01011 |    0.6100 |     1.135 |   0.07121 |
-#> |.....................|    0.8936 |   0.05935 |    0.7242 |    0.6734 |
-#> |.....................|     1.623 |    0.9691 |    0.6746 |     1.739 |
-#> |   11|     478.24707 |    0.9926 |    -1.098 |   -0.9118 |   -0.9388 |
-#> |.....................|   -0.9843 |   -0.9186 |  -0.02735 |   -0.4276 |
-#> |.....................|   -0.7088 |   -0.8464 |   -0.8736 |    -1.141 |
-#> |.....................|   -0.4354 |   -0.8680 |    -1.101 |   -0.3451 |
-#> |    U|     478.24707 |     90.33 |    -5.298 |   -0.8913 |    -2.201 |
-#> |.....................|    -4.597 |    0.4433 |     1.182 |   0.07143 |
-#> |.....................|    0.8988 |   0.05929 |    0.7334 |    0.6616 |
-#> |.....................|     1.694 |    0.9593 |    0.6674 |     1.848 |
-#> |    X|     478.24707 |     90.33 |  0.004999 |    0.2909 |    0.1107 |
-#> |.....................|   0.01008 |    0.6090 |     1.182 |   0.07143 |
-#> |.....................|    0.8988 |   0.05929 |    0.7334 |    0.6616 |
-#> |.....................|     1.694 |    0.9593 |    0.6674 |     1.848 |
-#> |    F| Forward Diff. |    -54.86 |     1.159 |   -0.2545 |    0.1198 |
-#> |.....................|    0.4779 |     1.320 |    -1.627 |     7.719 |
-#> |.....................|     1.488 |     1.194 |    -2.008 |    -4.434 |
-#> |.....................|     3.563 |    0.8010 |    -2.393 |    -3.495 |
-#> |   12|     475.90466 |     1.002 |    -1.127 |   -0.9233 |   -0.9398 |
-#> |.....................|   -0.9978 |   -0.9482 |  -0.05448 |   -0.6822 |
-#> |.....................|   -0.7579 |   -0.8801 |   -0.8190 |    -1.095 |
-#> |.....................|   -0.4550 |   -0.8498 |    -1.031 |   -0.2699 |
-#> |    U|     475.90466 |     91.18 |    -5.327 |   -0.9014 |    -2.202 |
-#> |.....................|    -4.610 |    0.4297 |     1.170 |   0.06405 |
-#> |.....................|    0.8785 |   0.05831 |    0.7733 |    0.7032 |
-#> |.....................|     1.671 |    0.9767 |    0.7277 |     1.939 |
-#> |    X|     475.90466 |     91.18 |  0.004860 |    0.2888 |    0.1106 |
-#> |.....................|  0.009950 |    0.6058 |     1.170 |   0.06405 |
-#> |.....................|    0.8785 |   0.05831 |    0.7733 |    0.7032 |
-#> |.....................|     1.671 |    0.9767 |    0.7277 |     1.939 |
-#> |    F| Forward Diff. |    -5.773 |     1.281 |   0.05418 |  -0.06269 |
-#> |.....................|    0.4104 |     1.812 |    -4.981 |     3.640 |
-#> |.....................|  -0.08126 |   0.09477 |    -1.092 |    -2.966 |
-#> |.....................|     5.262 |     2.712 |     3.245 |    -2.012 |
-#> |   13|     477.06760 |     1.030 |    -1.176 |   -0.9281 |   -0.9377 |
-#> |.....................|    -1.013 |    -1.011 |   0.09564 |   -0.8420 |
-#> |.....................|   -0.7668 |   -0.8907 |   -0.7738 |    -1.073 |
-#> |.....................|   -0.5619 |   -0.8693 |    -1.126 |   -0.1773 |
-#> |    U|      477.0676 |     93.71 |    -5.376 |   -0.9057 |    -2.200 |
-#> |.....................|    -4.625 |    0.4008 |     1.233 |   0.05941 |
-#> |.....................|    0.8748 |   0.05800 |    0.8064 |    0.7234 |
-#> |.....................|     1.545 |    0.9581 |    0.6461 |     2.051 |
-#> |    X|      477.0676 |     93.71 |  0.004627 |    0.2879 |    0.1108 |
-#> |.....................|  0.009799 |    0.5989 |     1.233 |   0.05941 |
-#> |.....................|    0.8748 |   0.05800 |    0.8064 |    0.7234 |
-#> |.....................|     1.545 |    0.9581 |    0.6461 |     2.051 |
-#> |   14|     477.20174 |     1.026 |    -1.143 |   -0.9246 |   -0.9391 |
-#> |.....................|    -1.003 |   -0.9695 | -0.001726 |   -0.7335 |
-#> |.....................|   -0.7599 |   -0.8831 |   -0.8043 |    -1.080 |
-#> |.....................|   -0.4976 |   -0.8627 |    -1.065 |   -0.2404 |
-#> |    U|     477.20174 |     93.37 |    -5.343 |   -0.9027 |    -2.201 |
-#> |.....................|    -4.615 |    0.4199 |     1.192 |   0.06256 |
-#> |.....................|    0.8776 |   0.05822 |    0.7840 |    0.7162 |
-#> |.....................|     1.621 |    0.9644 |    0.6988 |     1.975 |
-#> |    X|     477.20174 |     93.37 |  0.004782 |    0.2885 |    0.1106 |
-#> |.....................|  0.009899 |    0.6035 |     1.192 |   0.06256 |
-#> |.....................|    0.8776 |   0.05822 |    0.7840 |    0.7162 |
-#> |.....................|     1.621 |    0.9644 |    0.6988 |     1.975 |
-#> |   15|     476.22973 |     1.014 |    -1.129 |   -0.9234 |   -0.9397 |
-#> |.....................|   -0.9986 |   -0.9521 |  -0.04396 |   -0.6899 |
-#> |.....................|   -0.7577 |   -0.8803 |   -0.8167 |    -1.089 |
-#> |.....................|   -0.4661 |   -0.8555 |    -1.038 |   -0.2656 |
-#> |    U|     476.22973 |     92.29 |    -5.329 |   -0.9015 |    -2.202 |
-#> |.....................|    -4.611 |    0.4279 |     1.175 |   0.06382 |
-#> |.....................|    0.8785 |   0.05830 |    0.7750 |    0.7089 |
-#> |.....................|     1.658 |    0.9712 |    0.7218 |     1.944 |
-#> |    X|     476.22973 |     92.29 |  0.004847 |    0.2887 |    0.1106 |
-#> |.....................|  0.009941 |    0.6054 |     1.175 |   0.06382 |
-#> |.....................|    0.8785 |   0.05830 |    0.7750 |    0.7089 |
-#> |.....................|     1.658 |    0.9712 |    0.7218 |     1.944 |
-#> |   16|     475.87776 |     1.005 |    -1.127 |   -0.9233 |   -0.9398 |
-#> |.....................|   -0.9980 |   -0.9491 |  -0.05201 |   -0.6840 |
-#> |.....................|   -0.7578 |   -0.8802 |   -0.8184 |    -1.093 |
-#> |.....................|   -0.4576 |   -0.8511 |    -1.033 |   -0.2689 |
-#> |    U|     475.87776 |     91.44 |    -5.327 |   -0.9015 |    -2.202 |
-#> |.....................|    -4.610 |    0.4293 |     1.171 |   0.06399 |
-#> |.....................|    0.8785 |   0.05830 |    0.7737 |    0.7045 |
-#> |.....................|     1.668 |    0.9754 |    0.7263 |     1.940 |
-#> |    X|     475.87776 |     91.44 |  0.004857 |    0.2887 |    0.1106 |
-#> |.....................|  0.009948 |    0.6057 |     1.171 |   0.06399 |
-#> |.....................|    0.8785 |   0.05830 |    0.7737 |    0.7045 |
-#> |.....................|     1.668 |    0.9754 |    0.7263 |     1.940 |
-#> |    F| Forward Diff. |     16.12 |     1.298 |    0.4116 |  -0.09723 |
-#> |.....................|    0.4002 |     1.728 |    -4.991 |     3.781 |
-#> |.....................|  -0.06392 |   0.04117 |    -1.251 |   -0.6787 |
-#> |.....................|     5.079 |     2.620 |     3.013 |    -2.074 |
-#> |   17|     475.82399 |     1.002 |    -1.128 |   -0.9234 |   -0.9397 |
-#> |.....................|   -0.9982 |   -0.9501 |  -0.04950 |   -0.6866 |
-#> |.....................|   -0.7580 |   -0.8803 |   -0.8177 |    -1.093 |
-#> |.....................|   -0.4596 |   -0.8518 |    -1.034 |   -0.2675 |
-#> |    U|     475.82399 |     91.17 |    -5.328 |   -0.9016 |    -2.202 |
-#> |.....................|    -4.611 |    0.4288 |     1.172 |   0.06392 |
-#> |.....................|    0.8784 |   0.05830 |    0.7743 |    0.7045 |
-#> |.....................|     1.666 |    0.9748 |    0.7251 |     1.942 |
-#> |    X|     475.82399 |     91.17 |  0.004853 |    0.2887 |    0.1106 |
-#> |.....................|  0.009945 |    0.6056 |     1.172 |   0.06392 |
-#> |.....................|    0.8784 |   0.05830 |    0.7743 |    0.7045 |
-#> |.....................|     1.666 |    0.9748 |    0.7251 |     1.942 |
-#> |    F| Forward Diff. |    -7.267 |     1.279 |  0.007095 |  -0.05940 |
-#> |.....................|    0.4115 |     1.783 |    -5.114 |     3.652 |
-#> |.....................|   -0.1068 |    0.1083 |    -1.295 |   -0.9578 |
-#> |.....................|     2.682 |     2.514 |     3.014 |    -2.035 |
-#> |   18|     475.78862 |     1.005 |    -1.129 |   -0.9235 |   -0.9397 |
-#> |.....................|   -0.9985 |   -0.9512 |  -0.04657 |   -0.6892 |
-#> |.....................|   -0.7580 |   -0.8804 |   -0.8168 |    -1.093 |
-#> |.....................|   -0.4611 |   -0.8527 |    -1.036 |   -0.2661 |
-#> |    U|     475.78862 |     91.41 |    -5.329 |   -0.9016 |    -2.202 |
-#> |.....................|    -4.611 |    0.4283 |     1.174 |   0.06384 |
-#> |.....................|    0.8784 |   0.05830 |    0.7749 |    0.7045 |
-#> |.....................|     1.664 |    0.9739 |    0.7236 |     1.943 |
-#> |    X|     475.78862 |     91.41 |  0.004849 |    0.2887 |    0.1106 |
-#> |.....................|  0.009942 |    0.6055 |     1.174 |   0.06384 |
-#> |.....................|    0.8784 |   0.05830 |    0.7749 |    0.7045 |
-#> |.....................|     1.664 |    0.9739 |    0.7236 |     1.943 |
-#> |    F| Forward Diff. |     13.19 |     1.292 |    0.3498 |  -0.09321 |
-#> |.....................|    0.4023 |     1.703 |    -5.372 |     3.699 |
-#> |.....................|   -0.1234 |   0.05429 |    -1.241 |   -0.7588 |
-#> |.....................|     4.815 |     2.436 |     2.783 |    -2.083 |
-#> |   19|     475.73531 |     1.002 |    -1.130 |   -0.9236 |   -0.9397 |
-#> |.....................|   -0.9987 |   -0.9524 |  -0.04361 |   -0.6921 |
-#> |.....................|   -0.7582 |   -0.8806 |   -0.8159 |    -1.094 |
-#> |.....................|   -0.4630 |   -0.8531 |    -1.037 |   -0.2646 |
-#> |    U|     475.73531 |     91.21 |    -5.330 |   -0.9018 |    -2.202 |
-#> |.....................|    -4.611 |    0.4278 |     1.175 |   0.06376 |
-#> |.....................|    0.8783 |   0.05829 |    0.7756 |    0.7041 |
-#> |.....................|     1.662 |    0.9735 |    0.7222 |     1.945 |
-#> |    X|     475.73531 |     91.21 |  0.004845 |    0.2887 |    0.1106 |
-#> |.....................|  0.009940 |    0.6053 |     1.175 |   0.06376 |
-#> |.....................|    0.8783 |   0.05829 |    0.7756 |    0.7041 |
-#> |.....................|     1.662 |    0.9735 |    0.7222 |     1.945 |
-#> |    F| Forward Diff. |    -3.312 |     1.277 |   0.06663 |  -0.06695 |
-#> |.....................|    0.4102 |     1.736 |    -5.095 |     3.555 |
-#> |.....................|  -0.08175 |   0.08515 |    -1.253 |   -0.9364 |
-#> |.....................|     4.836 |     2.452 |     2.739 |    -2.058 |
-#> |   20|     475.69941 |     1.004 |    -1.131 |   -0.9237 |   -0.9396 |
-#> |.....................|   -0.9990 |   -0.9534 |  -0.04063 |   -0.6942 |
-#> |.....................|   -0.7581 |   -0.8807 |   -0.8151 |    -1.093 |
-#> |.....................|   -0.4658 |   -0.8545 |    -1.039 |   -0.2634 |
-#> |    U|     475.69941 |     91.39 |    -5.331 |   -0.9018 |    -2.202 |
-#> |.....................|    -4.611 |    0.4273 |     1.176 |   0.06370 |
-#> |.....................|    0.8783 |   0.05829 |    0.7761 |    0.7046 |
-#> |.....................|     1.658 |    0.9722 |    0.7208 |     1.947 |
-#> |    X|     475.69941 |     91.39 |  0.004841 |    0.2887 |    0.1106 |
-#> |.....................|  0.009937 |    0.6052 |     1.176 |   0.06370 |
-#> |.....................|    0.8783 |   0.05829 |    0.7761 |    0.7046 |
-#> |.....................|     1.658 |    0.9722 |    0.7208 |     1.947 |
-#> |    F| Forward Diff. |     11.57 |     1.287 |    0.3079 |  -0.08979 |
-#> |.....................|    0.4039 |     1.674 |    -5.153 |     3.653 |
-#> |.....................|  -0.06063 |   0.04440 |    -1.200 |   -0.7646 |
-#> |.....................|     2.452 |     2.339 |     2.552 |    -2.095 |
-#> |   21|     475.66307 |     1.001 |    -1.131 |   -0.9238 |   -0.9396 |
-#> |.....................|   -0.9992 |   -0.9545 |  -0.03780 |   -0.6969 |
-#> |.....................|   -0.7583 |   -0.8808 |   -0.8143 |    -1.094 |
-#> |.....................|   -0.4671 |   -0.8550 |    -1.041 |   -0.2620 |
-#> |    U|     475.66307 |     91.11 |    -5.331 |   -0.9019 |    -2.202 |
-#> |.....................|    -4.612 |    0.4268 |     1.177 |   0.06362 |
-#> |.....................|    0.8783 |   0.05829 |    0.7767 |    0.7044 |
-#> |.....................|     1.657 |    0.9717 |    0.7195 |     1.948 |
-#> |    X|     475.66307 |     91.11 |  0.004837 |    0.2887 |    0.1106 |
-#> |.....................|  0.009935 |    0.6051 |     1.177 |   0.06362 |
-#> |.....................|    0.8783 |   0.05829 |    0.7767 |    0.7044 |
-#> |.....................|     1.657 |    0.9717 |    0.7195 |     1.948 |
-#> |    F| Forward Diff. |    -12.57 |     1.267 |  -0.09715 |  -0.05310 |
-#> |.....................|    0.4138 |     1.728 |    -5.558 |     3.438 |
-#> |.....................|   -0.1081 |    0.1203 |    -1.232 |    -1.053 |
-#> |.....................|     2.344 |     2.291 |     2.543 |    -2.059 |
-#> |   22|     475.61346 |     1.003 |    -1.132 |   -0.9238 |   -0.9395 |
-#> |.....................|   -0.9995 |   -0.9557 |  -0.03467 |   -0.6999 |
-#> |.....................|   -0.7585 |   -0.8810 |   -0.8134 |    -1.094 |
-#> |.....................|   -0.4680 |   -0.8550 |    -1.042 |   -0.2607 |
-#> |    U|     475.61346 |     91.32 |    -5.332 |   -0.9020 |    -2.202 |
-#> |.....................|    -4.612 |    0.4262 |     1.179 |   0.06353 |
-#> |.....................|    0.8782 |   0.05828 |    0.7774 |    0.7040 |
-#> |.....................|     1.656 |    0.9717 |    0.7181 |     1.950 |
-#> |    X|     475.61346 |     91.32 |  0.004833 |    0.2886 |    0.1106 |
-#> |.....................|  0.009932 |    0.6050 |     1.179 |   0.06353 |
-#> |.....................|    0.8782 |   0.05828 |    0.7774 |    0.7040 |
-#> |.....................|     1.656 |    0.9717 |    0.7181 |     1.950 |
-#> |    F| Forward Diff. |     5.192 |     1.277 |    0.1967 |  -0.08157 |
-#> |.....................|    0.4060 |     1.656 |    -5.231 |     3.627 |
-#> |.....................|   -0.1038 |   0.05786 |    -1.199 |   -0.8859 |
-#> |.....................|     2.283 |     2.293 |     2.331 |    -2.101 |
-#> |   23|     475.58436 |     1.001 |    -1.133 |   -0.9239 |   -0.9395 |
-#> |.....................|   -0.9998 |   -0.9568 |  -0.03140 |   -0.7025 |
-#> |.....................|   -0.7585 |   -0.8810 |   -0.8126 |    -1.094 |
-#> |.....................|   -0.4692 |   -0.8560 |    -1.044 |   -0.2594 |
-#> |    U|     475.58436 |     91.09 |    -5.333 |   -0.9021 |    -2.202 |
-#> |.....................|    -4.612 |    0.4257 |     1.180 |   0.06346 |
-#> |.....................|    0.8782 |   0.05828 |    0.7780 |    0.7043 |
-#> |.....................|     1.654 |    0.9707 |    0.7167 |     1.952 |
-#> |    X|     475.58436 |     91.09 |  0.004829 |    0.2886 |    0.1106 |
-#> |.....................|  0.009929 |    0.6049 |     1.180 |   0.06346 |
-#> |.....................|    0.8782 |   0.05828 |    0.7780 |    0.7043 |
-#> |.....................|     1.654 |    0.9707 |    0.7167 |     1.952 |
-#> |    F| Forward Diff. |    -14.46 |     1.261 |   -0.1306 |  -0.05131 |
-#> |.....................|    0.4140 |     1.696 |    -5.518 |     3.404 |
-#> |.....................|   -0.1407 |    0.1181 |    -1.199 |    -1.071 |
-#> |.....................|     2.272 |     2.212 |     2.296 |    -2.075 |
-#> |   24|     475.53229 |     1.003 |    -1.134 |   -0.9240 |   -0.9394 |
-#> |.....................|    -1.000 |   -0.9581 |  -0.02828 |   -0.7055 |
-#> |.....................|   -0.7587 |   -0.8812 |   -0.8117 |    -1.094 |
-#> |.....................|   -0.4701 |   -0.8560 |    -1.045 |   -0.2580 |
-#> |    U|     475.53229 |     91.31 |    -5.334 |   -0.9021 |    -2.202 |
-#> |.....................|    -4.613 |    0.4251 |     1.181 |   0.06337 |
-#> |.....................|    0.8781 |   0.05828 |    0.7786 |    0.7039 |
-#> |.....................|     1.653 |    0.9708 |    0.7153 |     1.953 |
-#> |    X|     475.53229 |     91.31 |  0.004824 |    0.2886 |    0.1106 |
-#> |.....................|  0.009926 |    0.6047 |     1.181 |   0.06337 |
-#> |.....................|    0.8781 |   0.05828 |    0.7786 |    0.7039 |
-#> |.....................|     1.653 |    0.9708 |    0.7153 |     1.953 |
-#> |    F| Forward Diff. |     4.355 |     1.271 |    0.1786 |  -0.08149 |
-#> |.....................|    0.4055 |     1.621 |    -5.117 |     3.557 |
-#> |.....................|   -0.1060 |   0.04285 |   -0.9518 |    -2.902 |
-#> |.....................|     4.469 |     2.204 |     2.093 |    -2.115 |
-#> |   25|     475.50379 |     1.001 |    -1.135 |   -0.9241 |   -0.9394 |
-#> |.....................|    -1.000 |   -0.9591 |  -0.02533 |   -0.7076 |
-#> |.....................|   -0.7587 |   -0.8812 |   -0.8111 |    -1.093 |
-#> |.....................|   -0.4726 |   -0.8571 |    -1.047 |   -0.2568 |
-#> |    U|     475.50379 |     91.10 |    -5.335 |   -0.9022 |    -2.202 |
-#> |.....................|    -4.613 |    0.4247 |     1.182 |   0.06331 |
-#> |.....................|    0.8781 |   0.05828 |    0.7790 |    0.7053 |
-#> |.....................|     1.650 |    0.9697 |    0.7143 |     1.955 |
-#> |    X|     475.50379 |     91.10 |  0.004820 |    0.2886 |    0.1106 |
-#> |.....................|  0.009924 |    0.6046 |     1.182 |   0.06331 |
-#> |.....................|    0.8781 |   0.05828 |    0.7790 |    0.7053 |
-#> |.....................|     1.650 |    0.9697 |    0.7143 |     1.955 |
-#> |    F| Forward Diff. |    -13.73 |     1.259 |   -0.1294 |  -0.05234 |
-#> |.....................|    0.4131 |     1.659 |    -5.626 |     3.356 |
-#> |.....................|   -0.1179 |    0.1182 |    -1.163 |   -0.9759 |
-#> |.....................|     2.282 |     2.162 |     2.085 |    -2.085 |
-#> |   26|     475.45890 |     1.004 |    -1.136 |   -0.9240 |   -0.9393 |
-#> |.....................|    -1.001 |   -0.9602 |  -0.02221 |   -0.7103 |
-#> |.....................|   -0.7588 |   -0.8813 |   -0.8104 |    -1.092 |
-#> |.....................|   -0.4738 |   -0.8571 |    -1.048 |   -0.2555 |
-#> |    U|      475.4589 |     91.37 |    -5.336 |   -0.9021 |    -2.202 |
-#> |.....................|    -4.613 |    0.4242 |     1.184 |   0.06323 |
-#> |.....................|    0.8781 |   0.05827 |    0.7796 |    0.7056 |
-#> |.....................|     1.649 |    0.9697 |    0.7132 |     1.956 |
-#> |    X|      475.4589 |     91.37 |  0.004816 |    0.2886 |    0.1106 |
-#> |.....................|  0.009921 |    0.6045 |     1.184 |   0.06323 |
-#> |.....................|    0.8781 |   0.05827 |    0.7796 |    0.7056 |
-#> |.....................|     1.649 |    0.9697 |    0.7132 |     1.956 |
-#> |    F| Forward Diff. |     9.388 |     1.275 |    0.2447 |  -0.08891 |
-#> |.....................|    0.4027 |     1.576 |    -4.598 |     3.539 |
-#> |.....................|  -0.08390 |   0.04261 |   -0.9004 |    -2.725 |
-#> |.....................|     4.305 |     2.111 |     1.882 |    -2.135 |
-#> |   27|     475.41657 |     1.002 |    -1.137 |   -0.9241 |   -0.9392 |
-#> |.....................|    -1.001 |   -0.9615 |  -0.01910 |   -0.7133 |
-#> |.....................|   -0.7590 |   -0.8814 |   -0.8097 |    -1.092 |
-#> |.....................|   -0.4754 |   -0.8571 |    -1.049 |   -0.2540 |
-#> |    U|     475.41657 |     91.17 |    -5.337 |   -0.9022 |    -2.202 |
-#> |.....................|    -4.613 |    0.4236 |     1.185 |   0.06314 |
-#> |.....................|    0.8780 |   0.05827 |    0.7801 |    0.7060 |
-#> |.....................|     1.647 |    0.9697 |    0.7121 |     1.958 |
-#> |    X|     475.41657 |     91.17 |  0.004811 |    0.2886 |    0.1106 |
-#> |.....................|  0.009918 |    0.6043 |     1.185 |   0.06314 |
-#> |.....................|    0.8780 |   0.05827 |    0.7801 |    0.7060 |
-#> |.....................|     1.647 |    0.9697 |    0.7121 |     1.958 |
-#> |    F| Forward Diff. |    -7.291 |     1.263 |  -0.02799 |  -0.06240 |
-#> |.....................|    0.4098 |     1.607 |    -5.561 |     3.409 |
-#> |.....................|   -0.1363 |   0.09124 |    -1.126 |   -0.9025 |
-#> |.....................|     4.264 |     2.123 |     1.858 |    -2.103 |
-#> |   28|     475.37603 |     1.004 |    -1.138 |   -0.9241 |   -0.9392 |
-#> |.....................|    -1.001 |   -0.9626 |  -0.01569 |   -0.7160 |
-#> |.....................|   -0.7590 |   -0.8815 |   -0.8090 |    -1.092 |
-#> |.....................|   -0.4775 |   -0.8574 |    -1.050 |   -0.2525 |
-#> |    U|     475.37603 |     91.35 |    -5.338 |   -0.9022 |    -2.202 |
-#> |.....................|    -4.614 |    0.4231 |     1.186 |   0.06307 |
-#> |.....................|    0.8780 |   0.05827 |    0.7806 |    0.7060 |
-#> |.....................|     1.645 |    0.9695 |    0.7112 |     1.960 |
-#> |    X|     475.37603 |     91.35 |  0.004807 |    0.2886 |    0.1106 |
-#> |.....................|  0.009915 |    0.6042 |     1.186 |   0.06307 |
-#> |.....................|    0.8780 |   0.05827 |    0.7806 |    0.7060 |
-#> |.....................|     1.645 |    0.9695 |    0.7112 |     1.960 |
-#> |    F| Forward Diff. |     7.976 |     1.271 |    0.2167 |  -0.08766 |
-#> |.....................|    0.4024 |     1.550 |    -5.132 |     3.516 |
-#> |.....................|  -0.09627 |   0.04106 |    -1.088 |   -0.7404 |
-#> |.....................|     4.103 |     2.126 |     1.707 |    -2.133 |
-#> |   29|     475.34297 |     1.001 |    -1.139 |   -0.9242 |   -0.9391 |
-#> |.....................|    -1.002 |   -0.9636 |  -0.01242 |   -0.7185 |
-#> |.....................|   -0.7591 |   -0.8816 |   -0.8082 |    -1.092 |
-#> |.....................|   -0.4796 |   -0.8578 |    -1.051 |   -0.2511 |
-#> |    U|     475.34297 |     91.13 |    -5.339 |   -0.9023 |    -2.201 |
-#> |.....................|    -4.614 |    0.4226 |     1.188 |   0.06299 |
-#> |.....................|    0.8779 |   0.05826 |    0.7812 |    0.7056 |
-#> |.....................|     1.642 |    0.9691 |    0.7103 |     1.962 |
-#> |    X|     475.34297 |     91.13 |  0.004803 |    0.2886 |    0.1106 |
-#> |.....................|  0.009912 |    0.6041 |     1.188 |   0.06299 |
-#> |.....................|    0.8779 |   0.05826 |    0.7812 |    0.7056 |
-#> |.....................|     1.642 |    0.9691 |    0.7103 |     1.962 |
-#> |    F| Forward Diff. |    -11.69 |     1.251 |  -0.09758 |  -0.05188 |
-#> |.....................|    0.4100 |     1.596 |    -5.544 |     3.338 |
-#> |.....................|   -0.1288 |   0.09302 |    -1.103 |   -0.9943 |
-#> |.....................|     4.044 |     2.113 |     1.726 |    -2.096 |
-#> |   30|     475.29763 |     1.004 |    -1.140 |   -0.9242 |   -0.9391 |
-#> |.....................|    -1.002 |   -0.9647 | -0.009016 |   -0.7212 |
-#> |.....................|   -0.7592 |   -0.8817 |   -0.8074 |    -1.093 |
-#> |.....................|   -0.4815 |   -0.8578 |    -1.052 |   -0.2496 |
-#> |    U|     475.29763 |     91.33 |    -5.340 |   -0.9023 |    -2.201 |
-#> |.....................|    -4.614 |    0.4221 |     1.189 |   0.06292 |
-#> |.....................|    0.8779 |   0.05826 |    0.7818 |    0.7049 |
-#> |.....................|     1.640 |    0.9691 |    0.7096 |     1.964 |
-#> |    X|     475.29763 |     91.33 |  0.004798 |    0.2886 |    0.1106 |
-#> |.....................|  0.009909 |    0.6040 |     1.189 |   0.06292 |
-#> |.....................|    0.8779 |   0.05826 |    0.7818 |    0.7049 |
-#> |.....................|     1.640 |    0.9691 |    0.7096 |     1.964 |
-#> |    F| Forward Diff. |     5.626 |     1.261 |    0.1834 |  -0.08674 |
-#> |.....................|    0.4019 |     1.535 |    -5.612 |     3.466 |
-#> |.....................|   -0.1091 |   0.03444 |    -1.082 |   -0.8814 |
-#> |.....................|     3.882 |     2.084 |     1.576 |    -2.128 |
-#> |   31|     475.26968 |     1.001 |    -1.140 |   -0.9243 |   -0.9390 |
-#> |.....................|    -1.002 |   -0.9656 | -0.005554 |   -0.7235 |
-#> |.....................|   -0.7592 |   -0.8818 |   -0.8067 |    -1.093 |
-#> |.....................|   -0.4837 |   -0.8585 |    -1.053 |   -0.2482 |
-#> |    U|     475.26968 |     91.11 |    -5.340 |   -0.9024 |    -2.201 |
-#> |.....................|    -4.615 |    0.4217 |     1.191 |   0.06285 |
-#> |.....................|    0.8779 |   0.05826 |    0.7823 |    0.7049 |
-#> |.....................|     1.637 |    0.9684 |    0.7088 |     1.965 |
-#> |    X|     475.26968 |     91.11 |  0.004794 |    0.2886 |    0.1106 |
-#> |.....................|  0.009907 |    0.6039 |     1.191 |   0.06285 |
-#> |.....................|    0.8779 |   0.05826 |    0.7823 |    0.7049 |
-#> |.....................|     1.637 |    0.9684 |    0.7088 |     1.965 |
-#> |    F| Forward Diff. |    -13.71 |     1.246 |   -0.1255 |  -0.05322 |
-#> |.....................|    0.4099 |     1.581 |    -5.546 |     3.317 |
-#> |.....................|   -0.1509 |    0.1096 |   -0.8594 |    -3.000 |
-#> |.....................|     3.990 |     2.056 |     1.604 |    -2.087 |
-#> |   32|     475.22190 |     1.004 |    -1.141 |   -0.9243 |   -0.9390 |
-#> |.....................|    -1.002 |   -0.9667 | -0.002058 |   -0.7261 |
-#> |.....................|   -0.7593 |   -0.8819 |   -0.8061 |    -1.093 |
-#> |.....................|   -0.4854 |   -0.8583 |    -1.054 |   -0.2469 |
-#> |    U|      475.2219 |     91.33 |    -5.341 |   -0.9024 |    -2.201 |
-#> |.....................|    -4.615 |    0.4212 |     1.192 |   0.06277 |
-#> |.....................|    0.8778 |   0.05826 |    0.7828 |    0.7049 |
-#> |.....................|     1.635 |    0.9686 |    0.7081 |     1.967 |
-#> |    X|      475.2219 |     91.33 |  0.004790 |    0.2886 |    0.1107 |
-#> |.....................|  0.009904 |    0.6038 |     1.192 |   0.06277 |
-#> |.....................|    0.8778 |   0.05826 |    0.7828 |    0.7049 |
-#> |.....................|     1.635 |    0.9686 |    0.7081 |     1.967 |
-#> |    F| Forward Diff. |     5.841 |     1.258 |    0.1840 |  -0.08823 |
-#> |.....................|    0.4011 |     1.514 |    -4.992 |     3.441 |
-#> |.....................|   -0.1080 |   0.03852 |    -1.043 |   -0.8514 |
-#> |.....................|     3.826 |     2.019 |     1.451 |    -2.125 |
-#> |   33|     475.19540 |     1.001 |    -1.142 |   -0.9244 |   -0.9389 |
-#> |.....................|    -1.003 |   -0.9677 |  0.001228 |   -0.7286 |
-#> |.....................|   -0.7593 |   -0.8819 |   -0.8054 |    -1.093 |
-#> |.....................|   -0.4876 |   -0.8589 |    -1.055 |   -0.2455 |
-#> |    U|      475.1954 |     91.10 |    -5.342 |   -0.9025 |    -2.201 |
-#> |.....................|    -4.615 |    0.4207 |     1.193 |   0.06270 |
-#> |.....................|    0.8778 |   0.05825 |    0.7833 |    0.7050 |
-#> |.....................|     1.633 |    0.9680 |    0.7073 |     1.969 |
-#> |    X|      475.1954 |     91.10 |  0.004786 |    0.2885 |    0.1107 |
-#> |.....................|  0.009901 |    0.6037 |     1.193 |   0.06270 |
-#> |.....................|    0.8778 |   0.05825 |    0.7833 |    0.7050 |
-#> |.....................|     1.633 |    0.9680 |    0.7073 |     1.969 |
-#> |    F| Forward Diff. |    -14.17 |     1.239 |   -0.1323 |  -0.05443 |
-#> |.....................|    0.4093 |     1.561 |    -5.475 |     3.262 |
-#> |.....................|   -0.1301 |   0.09817 |    -1.038 |    -1.045 |
-#> |.....................|     3.818 |     2.054 |     1.474 |    -2.085 |
-#> |   34|     475.14668 |     1.003 |    -1.143 |   -0.9244 |   -0.9388 |
-#> |.....................|    -1.003 |   -0.9688 |  0.004635 |   -0.7312 |
-#> |.....................|   -0.7595 |   -0.8820 |   -0.8046 |    -1.094 |
-#> |.....................|   -0.4894 |   -0.8588 |    -1.055 |   -0.2440 |
-#> |    U|     475.14668 |     91.31 |    -5.343 |   -0.9025 |    -2.201 |
-#> |.....................|    -4.615 |    0.4202 |     1.195 |   0.06262 |
-#> |.....................|    0.8778 |   0.05825 |    0.7838 |    0.7043 |
-#> |.....................|     1.631 |    0.9681 |    0.7066 |     1.970 |
-#> |    X|     475.14668 |     91.31 |  0.004781 |    0.2885 |    0.1107 |
-#> |.....................|  0.009898 |    0.6035 |     1.195 |   0.06262 |
-#> |.....................|    0.8778 |   0.05825 |    0.7838 |    0.7043 |
-#> |.....................|     1.631 |    0.9681 |    0.7066 |     1.970 |
-#> |    F| Forward Diff. |     3.838 |     1.251 |    0.1547 |  -0.08725 |
-#> |.....................|    0.4006 |     1.498 |    -4.927 |     3.416 |
-#> |.....................|   -0.1219 |   0.06473 |    -1.010 |    -2.917 |
-#> |.....................|     3.712 |     2.020 |     1.337 |    -2.117 |
-#> |   35|     475.12366 |     1.001 |    -1.144 |   -0.9245 |   -0.9388 |
-#> |.....................|    -1.003 |   -0.9698 |  0.007665 |   -0.7333 |
-#> |.....................|   -0.7594 |   -0.8821 |   -0.8040 |    -1.092 |
-#> |.....................|   -0.4916 |   -0.8600 |    -1.056 |   -0.2427 |
-#> |    U|     475.12366 |     91.10 |    -5.344 |   -0.9025 |    -2.201 |
-#> |.....................|    -4.616 |    0.4198 |     1.196 |   0.06256 |
-#> |.....................|    0.8778 |   0.05825 |    0.7843 |    0.7059 |
-#> |.....................|     1.628 |    0.9669 |    0.7059 |     1.972 |
-#> |    X|     475.12366 |     91.10 |  0.004777 |    0.2885 |    0.1107 |
-#> |.....................|  0.009896 |    0.6034 |     1.196 |   0.06256 |
-#> |.....................|    0.8778 |   0.05825 |    0.7843 |    0.7059 |
-#> |.....................|     1.628 |    0.9669 |    0.7059 |     1.972 |
-#> |    F| Forward Diff. |    -14.75 |     1.239 |   -0.1466 |  -0.05465 |
-#> |.....................|    0.4082 |     1.541 |    -5.471 |     3.270 |
-#> |.....................|   -0.1342 |   0.09829 |    -1.014 |    -1.026 |
-#> |.....................|     3.624 |     1.932 |     1.359 |    -2.081 |
-#> |   36|     475.07465 |     1.004 |    -1.145 |   -0.9245 |   -0.9387 |
-#> |.....................|    -1.003 |   -0.9709 |   0.01108 |   -0.7360 |
-#> |.....................|   -0.7595 |   -0.8821 |   -0.8033 |    -1.092 |
-#> |.....................|   -0.4933 |   -0.8597 |    -1.057 |   -0.2414 |
-#> |    U|     475.07465 |     91.33 |    -5.345 |   -0.9025 |    -2.201 |
-#> |.....................|    -4.616 |    0.4193 |     1.198 |   0.06248 |
-#> |.....................|    0.8778 |   0.05825 |    0.7848 |    0.7058 |
-#> |.....................|     1.626 |    0.9672 |    0.7053 |     1.974 |
-#> |    X|     475.07465 |     91.33 |  0.004773 |    0.2885 |    0.1107 |
-#> |.....................|  0.009893 |    0.6033 |     1.198 |   0.06248 |
-#> |.....................|    0.8778 |   0.05825 |    0.7848 |    0.7058 |
-#> |.....................|     1.626 |    0.9672 |    0.7053 |     1.974 |
-#> |    F| Forward Diff. |     5.021 |     1.249 |    0.1599 |  -0.08992 |
-#> |.....................|    0.3985 |     1.471 |    -4.995 |     3.410 |
-#> |.....................|   -0.1196 |   0.03779 |   -0.9990 |    -2.873 |
-#> |.....................|     3.497 |     1.906 |     1.211 |    -2.119 |
-#> |   37|     475.04940 |     1.001 |    -1.146 |   -0.9245 |   -0.9386 |
-#> |.....................|    -1.004 |   -0.9719 |   0.01438 |   -0.7384 |
-#> |.....................|   -0.7594 |   -0.8822 |   -0.8026 |    -1.091 |
-#> |.....................|   -0.4953 |   -0.8604 |    -1.058 |   -0.2400 |
-#> |    U|      475.0494 |     91.11 |    -5.346 |   -0.9026 |    -2.201 |
-#> |.....................|    -4.616 |    0.4188 |     1.199 |   0.06242 |
-#> |.....................|    0.8778 |   0.05825 |    0.7853 |    0.7070 |
-#> |.....................|     1.623 |    0.9666 |    0.7046 |     1.975 |
-#> |    X|      475.0494 |     91.11 |  0.004769 |    0.2885 |    0.1107 |
-#> |.....................|  0.009890 |    0.6032 |     1.199 |   0.06242 |
-#> |.....................|    0.8778 |   0.05825 |    0.7853 |    0.7070 |
-#> |.....................|     1.623 |    0.9666 |    0.7046 |     1.975 |
-#> |    F| Forward Diff. |    -14.15 |     1.235 |   -0.1370 |  -0.05688 |
-#> |.....................|    0.4085 |     1.517 |    -5.494 |     3.160 |
-#> |.....................|   -0.1583 |    0.1112 |   -0.7821 |    -2.927 |
-#> |.....................|     3.432 |     1.909 |     1.245 |    -2.084 |
-#> |   38|     475.00092 |     1.004 |    -1.147 |   -0.9245 |   -0.9386 |
-#> |.....................|    -1.004 |   -0.9731 |   0.01792 |   -0.7411 |
-#> |.....................|   -0.7595 |   -0.8822 |   -0.8020 |    -1.090 |
-#> |.....................|   -0.4968 |   -0.8598 |    -1.059 |   -0.2387 |
-#> |    U|     475.00092 |     91.32 |    -5.347 |   -0.9025 |    -2.201 |
-#> |.....................|    -4.617 |    0.4182 |     1.200 |   0.06234 |
-#> |.....................|    0.8778 |   0.05825 |    0.7857 |    0.7077 |
-#> |.....................|     1.622 |    0.9671 |    0.7039 |     1.977 |
-#> |    X|     475.00092 |     91.32 |  0.004764 |    0.2885 |    0.1107 |
-#> |.....................|  0.009887 |    0.6031 |     1.200 |   0.06234 |
-#> |.....................|    0.8778 |   0.05825 |    0.7857 |    0.7077 |
-#> |.....................|     1.622 |    0.9671 |    0.7039 |     1.977 |
-#> |    F| Forward Diff. |     4.379 |     1.249 |    0.1419 |  -0.08698 |
-#> |.....................|    0.3989 |     1.449 |    -4.966 |     3.395 |
-#> |.....................|   -0.1055 |   0.03295 |   -0.9696 |   -0.7580 |
-#> |.....................|     3.283 |     1.918 |     1.096 |    -2.115 |
-#> |   39|     474.98492 |     1.001 |    -1.147 |   -0.9246 |   -0.9385 |
-#> |.....................|    -1.004 |   -0.9740 |   0.02115 |   -0.7433 |
-#> |.....................|   -0.7595 |   -0.8822 |   -0.8014 |    -1.089 |
-#> |.....................|   -0.4989 |   -0.8610 |    -1.059 |   -0.2373 |
-#> |    U|     474.98492 |     91.07 |    -5.347 |   -0.9026 |    -2.201 |
-#> |.....................|    -4.617 |    0.4178 |     1.202 |   0.06227 |
-#> |.....................|    0.8778 |   0.05825 |    0.7862 |    0.7081 |
-#> |.....................|     1.619 |    0.9660 |    0.7033 |     1.978 |
-#> |    X|     474.98492 |     91.07 |  0.004760 |    0.2885 |    0.1107 |
-#> |.....................|  0.009884 |    0.6030 |     1.202 |   0.06227 |
-#> |.....................|    0.8778 |   0.05825 |    0.7862 |    0.7081 |
-#> |.....................|     1.619 |    0.9660 |    0.7033 |     1.978 |
-#> |    F| Forward Diff. |    -17.65 |     1.231 |   -0.1920 |  -0.05242 |
-#> |.....................|    0.4084 |     1.504 |    -5.397 |     3.171 |
-#> |.....................|   -0.1354 |    0.1061 |   -0.9468 |   -0.9144 |
-#> |.....................|     1.271 |     1.859 |     1.156 |    -2.067 |
-#> |   40|     474.93249 |     1.004 |    -1.148 |   -0.9245 |   -0.9384 |
-#> |.....................|    -1.005 |   -0.9752 |   0.02452 |   -0.7460 |
-#> |.....................|   -0.7596 |   -0.8823 |   -0.8007 |    -1.090 |
-#> |.....................|   -0.5000 |   -0.8607 |    -1.060 |   -0.2361 |
-#> |    U|     474.93249 |     91.32 |    -5.348 |   -0.9026 |    -2.201 |
-#> |.....................|    -4.617 |    0.4173 |     1.203 |   0.06220 |
-#> |.....................|    0.8778 |   0.05824 |    0.7867 |    0.7073 |
-#> |.....................|     1.618 |    0.9663 |    0.7027 |     1.980 |
-#> |    X|     474.93249 |     91.32 |  0.004755 |    0.2885 |    0.1107 |
-#> |.....................|  0.009881 |    0.6028 |     1.203 |   0.06220 |
-#> |.....................|    0.8778 |   0.05824 |    0.7867 |    0.7073 |
-#> |.....................|     1.618 |    0.9663 |    0.7027 |     1.980 |
-#> |    F| Forward Diff. |     4.492 |     1.243 |    0.1448 |  -0.09052 |
-#> |.....................|    0.3963 |     1.427 |    -4.973 |     3.376 |
-#> |.....................|  -0.06414 |   0.02300 |   -0.7344 |    -2.787 |
-#> |.....................|     3.083 |     1.834 |    0.9813 |    -2.110 |
-#> |   41|     474.90355 |     1.001 |    -1.149 |   -0.9246 |   -0.9383 |
-#> |.....................|    -1.005 |   -0.9763 |   0.02806 |   -0.7486 |
-#> |.....................|   -0.7596 |   -0.8823 |   -0.8002 |    -1.089 |
-#> |.....................|   -0.5018 |   -0.8611 |    -1.061 |   -0.2347 |
-#> |    U|     474.90355 |     91.13 |    -5.349 |   -0.9026 |    -2.201 |
-#> |.....................|    -4.617 |    0.4168 |     1.205 |   0.06212 |
-#> |.....................|    0.8777 |   0.05824 |    0.7870 |    0.7084 |
-#> |.....................|     1.616 |    0.9659 |    0.7020 |     1.982 |
-#> |    X|     474.90355 |     91.13 |  0.004751 |    0.2885 |    0.1107 |
-#> |.....................|  0.009878 |    0.6027 |     1.205 |   0.06212 |
-#> |.....................|    0.8777 |   0.05824 |    0.7870 |    0.7084 |
-#> |.....................|     1.616 |    0.9659 |    0.7020 |     1.982 |
-#> |    F| Forward Diff. |    -12.15 |     1.229 |   -0.1075 |  -0.06320 |
-#> |.....................|    0.4033 |     1.463 |    -5.606 |     3.135 |
-#> |.....................|   -0.1416 |   0.07801 |   -0.9461 |    -2.867 |
-#> |.....................|     3.063 |     1.817 |     1.008 |    -2.075 |
-#> |   42|     474.85832 |     1.003 |    -1.150 |   -0.9245 |   -0.9383 |
-#> |.....................|    -1.005 |   -0.9775 |   0.03184 |   -0.7513 |
-#> |.....................|   -0.7597 |   -0.8823 |   -0.7996 |    -1.089 |
-#> |.....................|   -0.5032 |   -0.8605 |    -1.061 |   -0.2334 |
-#> |    U|     474.85832 |     91.32 |    -5.350 |   -0.9026 |    -2.201 |
-#> |.....................|    -4.618 |    0.4162 |     1.206 |   0.06204 |
-#> |.....................|    0.8777 |   0.05824 |    0.7875 |    0.7089 |
-#> |.....................|     1.614 |    0.9665 |    0.7015 |     1.983 |
-#> |    X|     474.85832 |     91.32 |  0.004746 |    0.2885 |    0.1107 |
-#> |.....................|  0.009875 |    0.6026 |     1.206 |   0.06204 |
-#> |.....................|    0.8777 |   0.05824 |    0.7875 |    0.7089 |
-#> |.....................|     1.614 |    0.9665 |    0.7015 |     1.983 |
-#> |    F| Forward Diff. |     3.689 |     1.242 |    0.1265 |  -0.09001 |
-#> |.....................|    0.3949 |     1.405 |    -5.495 |     3.344 |
-#> |.....................|   -0.1166 |   0.02645 |   -0.9105 |   -0.7126 |
-#> |.....................|     2.952 |     1.861 |    0.8779 |    -2.102 |
-#> |   43|     474.83791 |     1.001 |    -1.151 |   -0.9246 |   -0.9382 |
-#> |.....................|    -1.006 |   -0.9784 |   0.03545 |   -0.7535 |
-#> |.....................|   -0.7596 |   -0.8823 |   -0.7990 |    -1.088 |
-#> |.....................|   -0.5052 |   -0.8617 |    -1.062 |   -0.2320 |
-#> |    U|     474.83791 |     91.10 |    -5.351 |   -0.9027 |    -2.201 |
-#> |.....................|    -4.618 |    0.4158 |     1.208 |   0.06198 |
-#> |.....................|    0.8777 |   0.05824 |    0.7879 |    0.7094 |
-#> |.....................|     1.612 |    0.9653 |    0.7010 |     1.985 |
-#> |    X|     474.83791 |     91.10 |  0.004742 |    0.2885 |    0.1107 |
-#> |.....................|  0.009872 |    0.6025 |     1.208 |   0.06198 |
-#> |.....................|    0.8777 |   0.05824 |    0.7879 |    0.7094 |
-#> |.....................|     1.612 |    0.9653 |    0.7010 |     1.985 |
-#> |    F| Forward Diff. |    -15.77 |     1.225 |   -0.1616 |  -0.05944 |
-#> |.....................|    0.4032 |     1.455 |    -5.461 |     3.071 |
-#> |.....................|   -0.1419 |   0.08593 |   -0.9091 |   -0.8855 |
-#> |.....................|     2.951 |     1.791 |    0.9091 |    -2.062 |
-#> |   44|     474.78971 |     1.004 |    -1.152 |   -0.9246 |   -0.9381 |
-#> |.....................|    -1.006 |   -0.9794 |   0.03911 |   -0.7559 |
-#> |.....................|   -0.7597 |   -0.8824 |   -0.7984 |    -1.089 |
-#> |.....................|   -0.5068 |   -0.8614 |    -1.062 |   -0.2307 |
-#> |    U|     474.78971 |     91.33 |    -5.352 |   -0.9026 |    -2.200 |
-#> |.....................|    -4.618 |    0.4153 |     1.209 |   0.06191 |
-#> |.....................|    0.8777 |   0.05824 |    0.7883 |    0.7086 |
-#> |.....................|     1.610 |    0.9656 |    0.7006 |     1.986 |
-#> |    X|     474.78971 |     91.33 |  0.004738 |    0.2885 |    0.1107 |
-#> |.....................|  0.009869 |    0.6024 |     1.209 |   0.06191 |
-#> |.....................|    0.8777 |   0.05824 |    0.7883 |    0.7086 |
-#> |.....................|     1.610 |    0.9656 |    0.7006 |     1.986 |
-#> |    F| Forward Diff. |     4.398 |     1.237 |    0.1402 |  -0.09195 |
-#> |.....................|    0.3940 |     1.388 |    -4.885 |     3.322 |
-#> |.....................|   -0.1374 |   0.01792 |   -0.6865 |    -2.709 |
-#> |.....................|     2.810 |     1.778 |    0.8100 |    -2.095 |
-#> |   45|     474.76763 |     1.001 |    -1.153 |   -0.9247 |   -0.9380 |
-#> |.....................|    -1.006 |   -0.9804 |   0.04256 |   -0.7584 |
-#> |.....................|   -0.7597 |   -0.8824 |   -0.7979 |    -1.088 |
-#> |.....................|   -0.5086 |   -0.8621 |    -1.063 |   -0.2293 |
-#> |    U|     474.76763 |     91.11 |    -5.353 |   -0.9027 |    -2.200 |
-#> |.....................|    -4.619 |    0.4149 |     1.211 |   0.06184 |
-#> |.....................|    0.8777 |   0.05824 |    0.7887 |    0.7097 |
-#> |.....................|     1.608 |    0.9650 |    0.7001 |     1.988 |
-#> |    X|     474.76763 |     91.11 |  0.004734 |    0.2885 |    0.1108 |
-#> |.....................|  0.009867 |    0.6023 |     1.211 |   0.06184 |
-#> |.....................|    0.8777 |   0.05824 |    0.7887 |    0.7097 |
-#> |.....................|     1.608 |    0.9650 |    0.7001 |     1.988 |
-#> |    F| Forward Diff. |    -14.92 |     1.222 |   -0.1466 |  -0.06186 |
-#> |.....................|    0.4014 |     1.433 |    -4.989 |     3.157 |
-#> |.....................|   -0.1326 |   0.08284 |   -0.6789 |    -2.803 |
-#> |.....................|     2.814 |     1.775 |    0.8327 |    -2.053 |
-#> |   46|     474.71973 |     1.004 |    -1.154 |   -0.9246 |   -0.9379 |
-#> |.....................|    -1.006 |   -0.9816 |   0.04617 |   -0.7611 |
-#> |.....................|   -0.7597 |   -0.8824 |   -0.7975 |    -1.087 |
-#> |.....................|   -0.5100 |   -0.8614 |    -1.064 |   -0.2281 |
-#> |    U|     474.71973 |     91.32 |    -5.354 |   -0.9026 |    -2.200 |
-#> |.....................|    -4.619 |    0.4143 |     1.212 |   0.06176 |
-#> |.....................|    0.8777 |   0.05824 |    0.7890 |    0.7100 |
-#> |.....................|     1.606 |    0.9656 |    0.6996 |     1.990 |
-#> |    X|     474.71973 |     91.32 |  0.004729 |    0.2885 |    0.1108 |
-#> |.....................|  0.009863 |    0.6021 |     1.212 |   0.06176 |
-#> |.....................|    0.8777 |   0.05824 |    0.7890 |    0.7100 |
-#> |.....................|     1.606 |    0.9656 |    0.6996 |     1.990 |
-#> |    F| Forward Diff. |     4.021 |     1.236 |    0.1299 |  -0.09158 |
-#> |.....................|    0.3929 |     1.368 |    -4.925 |     3.331 |
-#> |.....................|  -0.07142 |   0.08893 |   -0.6522 |    -2.634 |
-#> |.....................|     2.639 |     1.780 |    0.7273 |    -2.085 |
-#> |   47|     474.70040 |     1.001 |    -1.155 |   -0.9247 |   -0.9379 |
-#> |.....................|    -1.007 |   -0.9826 |   0.04954 |   -0.7634 |
-#> |.....................|   -0.7597 |   -0.8825 |   -0.7971 |    -1.086 |
-#> |.....................|   -0.5117 |   -0.8624 |    -1.064 |   -0.2267 |
-#> |    U|      474.7004 |     91.10 |    -5.355 |   -0.9027 |    -2.200 |
-#> |.....................|    -4.619 |    0.4139 |     1.214 |   0.06169 |
-#> |.....................|    0.8777 |   0.05824 |    0.7893 |    0.7114 |
-#> |.....................|     1.604 |    0.9647 |    0.6992 |     1.991 |
-#> |    X|      474.7004 |     91.10 |  0.004724 |    0.2885 |    0.1108 |
-#> |.....................|  0.009861 |    0.6020 |     1.214 |   0.06169 |
-#> |.....................|    0.8777 |   0.05824 |    0.7893 |    0.7114 |
-#> |.....................|     1.604 |    0.9647 |    0.6992 |     1.991 |
-#> |    F| Forward Diff. |    -15.76 |     1.220 |   -0.1617 |  -0.06091 |
-#> |.....................|    0.4007 |     1.415 |    -5.116 |     3.166 |
-#> |.....................|   -0.1298 |   0.07714 |   -0.6701 |    -2.700 |
-#> |.....................|     2.670 |     1.748 |    0.7590 |    -2.043 |
-#> |   48|     474.65116 |     1.003 |    -1.156 |   -0.9246 |   -0.9378 |
-#> |.....................|    -1.007 |   -0.9837 |   0.05321 |   -0.7662 |
-#> |.....................|   -0.7598 |   -0.8825 |   -0.7967 |    -1.086 |
-#> |.....................|   -0.5130 |   -0.8617 |    -1.065 |   -0.2255 |
-#> |    U|     474.65116 |     91.32 |    -5.356 |   -0.9026 |    -2.200 |
-#> |.....................|    -4.620 |    0.4134 |     1.215 |   0.06161 |
-#> |.....................|    0.8777 |   0.05824 |    0.7896 |    0.7116 |
-#> |.....................|     1.603 |    0.9653 |    0.6987 |     1.993 |
-#> |    X|     474.65116 |     91.32 |  0.004720 |    0.2885 |    0.1108 |
-#> |.....................|  0.009857 |    0.6019 |     1.215 |   0.06161 |
-#> |.....................|    0.8777 |   0.05824 |    0.7896 |    0.7116 |
-#> |.....................|     1.603 |    0.9653 |    0.6987 |     1.993 |
-#> |    F| Forward Diff. |     3.462 |     1.239 |    0.1107 |  -0.09136 |
-#> |.....................|    0.3915 |     1.348 |    -5.441 |     3.268 |
-#> |.....................|   -0.1113 |   0.02510 |   -0.6252 |    -2.485 |
-#> |.....................|     2.647 |     1.796 |    0.6587 |    -2.076 |
-#> |   49|     474.63065 |     1.001 |    -1.157 |   -0.9247 |   -0.9377 |
-#> |.....................|    -1.007 |   -0.9846 |   0.05678 |   -0.7683 |
-#> |.....................|   -0.7597 |   -0.8825 |   -0.7963 |    -1.084 |
-#> |.....................|   -0.5148 |   -0.8629 |    -1.065 |   -0.2241 |
-#> |    U|     474.63065 |     91.11 |    -5.357 |   -0.9027 |    -2.200 |
-#> |.....................|    -4.620 |    0.4129 |     1.217 |   0.06155 |
-#> |.....................|    0.8777 |   0.05824 |    0.7899 |    0.7131 |
-#> |.....................|     1.600 |    0.9642 |    0.6984 |     1.994 |
-#> |    X|     474.63065 |     91.11 |  0.004716 |    0.2885 |    0.1108 |
-#> |.....................|  0.009855 |    0.6018 |     1.217 |   0.06155 |
-#> |.....................|    0.8777 |   0.05824 |    0.7899 |    0.7131 |
-#> |.....................|     1.600 |    0.9642 |    0.6984 |     1.994 |
-#> |    F| Forward Diff. |    -14.93 |     1.220 |   -0.1531 |  -0.06288 |
-#> |.....................|    0.3983 |     1.394 |    -5.436 |     3.113 |
-#> |.....................|   -0.1458 |   0.07621 |   -0.8397 |   -0.6848 |
-#> |.....................|     2.501 |     1.690 |    0.6891 |    -2.034 |
-#> |   50|     474.58497 |     1.004 |    -1.158 |   -0.9246 |   -0.9376 |
-#> |.....................|    -1.008 |   -0.9857 |   0.06060 |   -0.7708 |
-#> |.....................|   -0.7598 |   -0.8826 |   -0.7958 |    -1.084 |
-#> |.....................|   -0.5162 |   -0.8624 |    -1.065 |   -0.2230 |
-#> |    U|     474.58497 |     91.34 |    -5.358 |   -0.9027 |    -2.200 |
-#> |.....................|    -4.620 |    0.4125 |     1.218 |   0.06148 |
-#> |.....................|    0.8777 |   0.05824 |    0.7902 |    0.7126 |
-#> |.....................|     1.599 |    0.9647 |    0.6980 |     1.996 |
-#> |    X|     474.58497 |     91.34 |  0.004711 |    0.2885 |    0.1108 |
-#> |.....................|  0.009852 |    0.6017 |     1.218 |   0.06148 |
-#> |.....................|    0.8777 |   0.05824 |    0.7902 |    0.7126 |
-#> |.....................|     1.599 |    0.9647 |    0.6980 |     1.996 |
-#> |    F| Forward Diff. |     5.248 |     1.234 |    0.1371 |  -0.09456 |
-#> |.....................|    0.3896 |     1.328 |    -5.011 |     3.180 |
-#> |.....................|   -0.1110 |  0.004022 |   -0.8103 |   -0.4964 |
-#> |.....................|     2.349 |     1.713 |    0.5705 |    -2.061 |
-#> |   51|     474.55760 |     1.002 |    -1.159 |   -0.9247 |   -0.9376 |
-#> |.....................|    -1.008 |   -0.9867 |   0.06444 |   -0.7734 |
-#> |.....................|   -0.7598 |   -0.8826 |   -0.7952 |    -1.085 |
-#> |.....................|   -0.5178 |   -0.8626 |    -1.066 |   -0.2215 |
-#> |    U|      474.5576 |     91.15 |    -5.359 |   -0.9027 |    -2.200 |
-#> |.....................|    -4.620 |    0.4120 |     1.220 |   0.06140 |
-#> |.....................|    0.8777 |   0.05824 |    0.7907 |    0.7122 |
-#> |.....................|     1.597 |    0.9645 |    0.6977 |     1.998 |
-#> |    X|      474.5576 |     91.15 |  0.004706 |    0.2885 |    0.1108 |
-#> |.....................|  0.009849 |    0.6016 |     1.220 |   0.06140 |
-#> |.....................|    0.8777 |   0.05824 |    0.7907 |    0.7122 |
-#> |.....................|     1.597 |    0.9645 |    0.6977 |     1.998 |
-#> |    F| Forward Diff. |    -11.86 |     1.219 |   -0.1003 |  -0.07615 |
-#> |.....................|    0.3954 |     1.369 |    -4.929 |     3.171 |
-#> |.....................|   -0.1229 |   0.06540 |   -0.8183 |   -0.7141 |
-#> |.....................|     2.360 |     1.696 |    0.6359 |    -2.032 |
-#> |   52|     474.51619 |     1.004 |    -1.160 |   -0.9246 |   -0.9375 |
-#> |.....................|    -1.008 |   -0.9878 |   0.06816 |   -0.7761 |
-#> |.....................|   -0.7599 |   -0.8826 |   -0.7946 |    -1.086 |
-#> |.....................|   -0.5193 |   -0.8622 |    -1.066 |   -0.2202 |
-#> |    U|     474.51619 |     91.33 |    -5.360 |   -0.9027 |    -2.200 |
-#> |.....................|    -4.621 |    0.4115 |     1.221 |   0.06132 |
-#> |.....................|    0.8776 |   0.05823 |    0.7911 |    0.7113 |
-#> |.....................|     1.595 |    0.9648 |    0.6972 |     1.999 |
-#> |    X|     474.51619 |     91.33 |  0.004702 |    0.2885 |    0.1108 |
-#> |.....................|  0.009846 |    0.6014 |     1.221 |   0.06132 |
-#> |.....................|    0.8776 |   0.05823 |    0.7911 |    0.7113 |
-#> |.....................|     1.595 |    0.9648 |    0.6972 |     1.999 |
-#> |    F| Forward Diff. |     4.413 |     1.225 |    0.1371 |  -0.09620 |
-#> |.....................|    0.3880 |     1.314 |    -5.554 |     3.197 |
-#> |.....................|  -0.07604 |  0.008867 |   -0.7931 |   -0.6282 |
-#> |.....................|     2.148 |     1.715 |    0.5273 |    -2.052 |
-#> |   53|     474.48673 |     1.002 |    -1.161 |   -0.9247 |   -0.9374 |
-#> |.....................|    -1.009 |   -0.9889 |   0.07224 |   -0.7786 |
-#> |.....................|   -0.7599 |   -0.8826 |   -0.7941 |    -1.086 |
-#> |.....................|   -0.5208 |   -0.8625 |    -1.067 |   -0.2188 |
-#> |    U|     474.48673 |     91.17 |    -5.361 |   -0.9027 |    -2.200 |
-#> |.....................|    -4.621 |    0.4110 |     1.223 |   0.06125 |
-#> |.....................|    0.8776 |   0.05823 |    0.7915 |    0.7110 |
-#> |.....................|     1.593 |    0.9645 |    0.6969 |     2.001 |
-#> |    X|     474.48673 |     91.17 |  0.004697 |    0.2885 |    0.1108 |
-#> |.....................|  0.009843 |    0.6013 |     1.223 |   0.06125 |
-#> |.....................|    0.8776 |   0.05823 |    0.7915 |    0.7110 |
-#> |.....................|     1.593 |    0.9645 |    0.6969 |     2.001 |
-#> |    F| Forward Diff. |    -10.51 |     1.211 |  -0.06554 |  -0.07429 |
-#> |.....................|    0.3932 |     1.350 |    -4.456 |     3.182 |
-#> |.....................|  -0.08901 |   0.05354 |   -0.5957 |    -2.739 |
-#> |.....................|     2.160 |     1.696 |    0.5687 |    -2.022 |
-#> |   54|     474.45218 |     1.004 |    -1.162 |   -0.9246 |   -0.9373 |
-#> |.....................|    -1.009 |   -0.9900 |   0.07590 |   -0.7814 |
-#> |.....................|   -0.7601 |   -0.8826 |   -0.7937 |    -1.086 |
-#> |.....................|   -0.5220 |   -0.8620 |    -1.067 |   -0.2177 |
-#> |    U|     474.45218 |     91.40 |    -5.362 |   -0.9027 |    -2.200 |
-#> |.....................|    -4.621 |    0.4105 |     1.224 |   0.06117 |
-#> |.....................|    0.8776 |   0.05823 |    0.7918 |    0.7111 |
-#> |.....................|     1.592 |    0.9650 |    0.6965 |     2.002 |
-#> |    X|     474.45218 |     91.40 |  0.004692 |    0.2885 |    0.1108 |
-#> |.....................|  0.009840 |    0.6012 |     1.224 |   0.06117 |
-#> |.....................|    0.8776 |   0.05823 |    0.7918 |    0.7111 |
-#> |.....................|     1.592 |    0.9650 |    0.6965 |     2.002 |
-#> |    F| Forward Diff. |     9.724 |     1.224 |    0.2009 |   -0.1069 |
-#> |.....................|    0.3834 |     1.279 |    -5.556 |     3.324 |
-#> |.....................|   -0.1101 |  -0.01912 |   -0.5638 |    -2.553 |
-#> |.....................|     2.043 |     1.731 |    0.4140 |    -2.044 |
-#> |   55|     474.41257 |     1.003 |    -1.163 |   -0.9246 |   -0.9371 |
-#> |.....................|    -1.009 |   -0.9913 |   0.07979 |   -0.7844 |
-#> |.....................|   -0.7601 |   -0.8825 |   -0.7935 |    -1.085 |
-#> |.....................|   -0.5231 |   -0.8612 |    -1.068 |   -0.2167 |
-#> |    U|     474.41257 |     91.25 |    -5.363 |   -0.9026 |    -2.199 |
-#> |.....................|    -4.622 |    0.4099 |     1.226 |   0.06108 |
-#> |.....................|    0.8775 |   0.05824 |    0.7919 |    0.7118 |
-#> |.....................|     1.591 |    0.9658 |    0.6961 |     2.004 |
-#> |    X|     474.41257 |     91.25 |  0.004687 |    0.2885 |    0.1109 |
-#> |.....................|  0.009836 |    0.6011 |     1.226 |   0.06108 |
-#> |.....................|    0.8775 |   0.05824 |    0.7919 |    0.7118 |
-#> |.....................|     1.591 |    0.9658 |    0.6961 |     2.004 |
-#> |    F| Forward Diff. |    -3.208 |     1.213 |   0.03978 |  -0.08693 |
-#> |.....................|    0.3876 |     1.303 |    -5.023 |     3.218 |
-#> |.....................|   -0.1347 |   0.02311 |   -0.7771 |   -0.6556 |
-#> |.....................|     2.056 |     1.822 |    0.4520 |    -2.025 |
-#> |   56|     474.39271 |     1.005 |    -1.164 |   -0.9246 |   -0.9371 |
-#> |.....................|    -1.010 |   -0.9922 |   0.08348 |   -0.7867 |
-#> |.....................|   -0.7600 |   -0.8825 |   -0.7930 |    -1.085 |
-#> |.....................|   -0.5246 |   -0.8625 |    -1.068 |   -0.2152 |
-#> |    U|     474.39271 |     91.47 |    -5.364 |   -0.9027 |    -2.199 |
-#> |.....................|    -4.622 |    0.4094 |     1.228 |   0.06101 |
-#> |.....................|    0.8776 |   0.05824 |    0.7923 |    0.7123 |
-#> |.....................|     1.589 |    0.9645 |    0.6958 |     2.005 |
-#> |    X|     474.39271 |     91.47 |  0.004683 |    0.2885 |    0.1109 |
-#> |.....................|  0.009833 |    0.6010 |     1.228 |   0.06101 |
-#> |.....................|    0.8776 |   0.05824 |    0.7923 |    0.7123 |
-#> |.....................|     1.589 |    0.9645 |    0.6958 |     2.005 |
-#> |    F| Forward Diff. |     15.86 |     1.227 |    0.2807 |   -0.1163 |
-#> |.....................|    0.3793 |     1.243 |    -5.494 |     3.329 |
-#> |.....................|  -0.09368 |   0.01293 |   -0.5149 |    -2.407 |
-#> |.....................|     1.979 |     1.686 |    0.3308 |    -2.044 |
-#> |   57|     474.34538 |     1.003 |    -1.165 |   -0.9247 |   -0.9369 |
-#> |.....................|    -1.010 |   -0.9934 |   0.08718 |   -0.7897 |
-#> |.....................|   -0.7601 |   -0.8825 |   -0.7926 |    -1.086 |
-#> |.....................|   -0.5258 |   -0.8620 |    -1.068 |   -0.2141 |
-#> |    U|     474.34538 |     91.27 |    -5.365 |   -0.9027 |    -2.199 |
-#> |.....................|    -4.622 |    0.4089 |     1.229 |   0.06093 |
-#> |.....................|    0.8775 |   0.05824 |    0.7926 |    0.7117 |
-#> |.....................|     1.587 |    0.9650 |    0.6954 |     2.007 |
-#> |    X|     474.34538 |     91.27 |  0.004677 |    0.2885 |    0.1109 |
-#> |.....................|  0.009830 |    0.6008 |     1.229 |   0.06093 |
-#> |.....................|    0.8775 |   0.05824 |    0.7926 |    0.7117 |
-#> |.....................|     1.587 |    0.9650 |    0.6954 |     2.007 |
-#> |    F| Forward Diff. |    -2.345 |     1.210 |   0.04189 |  -0.08986 |
-#> |.....................|    0.3855 |     1.284 |    -5.145 |     3.218 |
-#> |.....................|   -0.1284 |   0.01309 |   -0.7466 |   -0.6536 |
-#> |.....................|     1.964 |     1.743 |    0.3816 |    -2.008 |
-#> |   58|     474.31834 |     1.005 |    -1.166 |   -0.9247 |   -0.9369 |
-#> |.....................|    -1.010 |   -0.9944 |   0.09109 |   -0.7921 |
-#> |.....................|   -0.7600 |   -0.8825 |   -0.7920 |    -1.085 |
-#> |.....................|   -0.5273 |   -0.8633 |    -1.069 |   -0.2126 |
-#> |    U|     474.31834 |     91.43 |    -5.366 |   -0.9027 |    -2.199 |
-#> |.....................|    -4.623 |    0.4085 |     1.231 |   0.06086 |
-#> |.....................|    0.8776 |   0.05824 |    0.7930 |    0.7121 |
-#> |.....................|     1.586 |    0.9638 |    0.6952 |     2.008 |
-#> |    X|     474.31834 |     91.43 |  0.004673 |    0.2885 |    0.1109 |
-#> |.....................|  0.009827 |    0.6007 |     1.231 |   0.06086 |
-#> |.....................|    0.8776 |   0.05824 |    0.7930 |    0.7121 |
-#> |.....................|     1.586 |    0.9638 |    0.6952 |     2.008 |
-#> |    F| Forward Diff. |     12.13 |     1.219 |    0.2312 |   -0.1125 |
-#> |.....................|    0.3787 |     1.238 |    -5.317 |     3.196 |
-#> |.....................|  -0.08361 |  -0.02599 |   -0.7000 |   -0.4940 |
-#> |.....................|     1.837 |     1.637 |    0.3211 |    -2.028 |
-#> |   59|     474.27833 |     1.003 |    -1.167 |   -0.9247 |   -0.9368 |
-#> |.....................|    -1.010 |   -0.9955 |   0.09487 |   -0.7949 |
-#> |.....................|   -0.7601 |   -0.8825 |   -0.7915 |    -1.086 |
-#> |.....................|   -0.5286 |   -0.8630 |    -1.069 |   -0.2114 |
-#> |    U|     474.27833 |     91.25 |    -5.367 |   -0.9028 |    -2.199 |
-#> |.....................|    -4.623 |    0.4080 |     1.232 |   0.06078 |
-#> |.....................|    0.8775 |   0.05824 |    0.7934 |    0.7111 |
-#> |.....................|     1.584 |    0.9640 |    0.6948 |     2.010 |
-#> |    X|     474.27833 |     91.25 |  0.004668 |    0.2885 |    0.1109 |
-#> |.....................|  0.009824 |    0.6006 |     1.232 |   0.06078 |
-#> |.....................|    0.8775 |   0.05824 |    0.7934 |    0.7111 |
-#> |.....................|     1.584 |    0.9640 |    0.6948 |     2.010 |
-#> |    F| Forward Diff. |    -4.145 |     1.202 |   0.02355 |  -0.08919 |
-#> |.....................|    0.3842 |     1.275 |    -5.102 |     3.189 |
-#> |.....................|   -0.1071 |   0.01700 |   -0.7283 |   -0.7209 |
-#> |.....................|     1.776 |     1.686 |    0.3249 |    -1.982 |
-#> |   60|     474.25305 |     1.005 |    -1.168 |   -0.9247 |   -0.9367 |
-#> |.....................|    -1.011 |   -0.9965 |   0.09878 |   -0.7975 |
-#> |.....................|   -0.7601 |   -0.8825 |   -0.7909 |    -1.086 |
-#> |.....................|   -0.5300 |   -0.8636 |    -1.069 |   -0.2100 |
-#> |    U|     474.25305 |     91.44 |    -5.368 |   -0.9028 |    -2.199 |
-#> |.....................|    -4.623 |    0.4075 |     1.234 |   0.06070 |
-#> |.....................|    0.8775 |   0.05824 |    0.7938 |    0.7109 |
-#> |.....................|     1.583 |    0.9635 |    0.6946 |     2.012 |
-#> |    X|     474.25305 |     91.44 |  0.004663 |    0.2885 |    0.1109 |
-#> |.....................|  0.009821 |    0.6005 |     1.234 |   0.06070 |
-#> |.....................|    0.8775 |   0.05824 |    0.7938 |    0.7109 |
-#> |.....................|     1.583 |    0.9635 |    0.6946 |     2.012 |
-#> |    F| Forward Diff. |     13.11 |     1.213 |    0.2527 |   -0.1161 |
-#> |.....................|    0.3767 |     1.219 |    -5.003 |     3.213 |
-#> |.....................|  -0.09270 |  -0.04298 |   -0.4814 |    -2.533 |
-#> |.....................|     1.730 |     1.613 |    0.2495 |    -2.014 |
-#> |   61|     474.21254 |     1.003 |    -1.169 |   -0.9248 |   -0.9365 |
-#> |.....................|    -1.011 |   -0.9977 |    0.1025 |   -0.8005 |
-#> |.....................|   -0.7602 |   -0.8824 |   -0.7906 |    -1.087 |
-#> |.....................|   -0.5311 |   -0.8630 |    -1.070 |   -0.2089 |
-#> |    U|     474.21254 |     91.24 |    -5.369 |   -0.9028 |    -2.199 |
-#> |.....................|    -4.624 |    0.4069 |     1.236 |   0.06062 |
-#> |.....................|    0.8775 |   0.05824 |    0.7941 |    0.7105 |
-#> |.....................|     1.581 |    0.9641 |    0.6942 |     2.013 |
-#> |    X|     474.21254 |     91.24 |  0.004658 |    0.2885 |    0.1109 |
-#> |.....................|  0.009817 |    0.6003 |     1.236 |   0.06062 |
-#> |.....................|    0.8775 |   0.05824 |    0.7941 |    0.7105 |
-#> |.....................|     1.581 |    0.9641 |    0.6942 |     2.013 |
-#> |    F| Forward Diff. |    -5.267 |     1.195 |   0.01760 |  -0.08987 |
-#> |.....................|    0.3825 |     1.260 |    -5.272 |     3.141 |
-#> |.....................|   -0.1336 |  0.009843 |   -0.5186 |    -2.706 |
-#> |.....................|     1.727 |     1.652 |    0.2904 |    -1.976 |
-#> |   62|     474.18171 |     1.004 |    -1.170 |   -0.9247 |   -0.9364 |
-#> |.....................|    -1.011 |   -0.9989 |    0.1065 |   -0.8033 |
-#> |.....................|   -0.7602 |   -0.8823 |   -0.7904 |    -1.086 |
-#> |.....................|   -0.5322 |   -0.8627 |    -1.070 |   -0.2078 |
-#> |    U|     474.18171 |     91.41 |    -5.370 |   -0.9028 |    -2.199 |
-#> |.....................|    -4.624 |    0.4064 |     1.237 |   0.06054 |
-#> |.....................|    0.8775 |   0.05824 |    0.7942 |    0.7112 |
-#> |.....................|     1.580 |    0.9644 |    0.6939 |     2.014 |
-#> |    X|     474.18171 |     91.41 |  0.004653 |    0.2885 |    0.1109 |
-#> |.....................|  0.009814 |    0.6002 |     1.237 |   0.06054 |
-#> |.....................|    0.8775 |   0.05824 |    0.7942 |    0.7112 |
-#> |.....................|     1.580 |    0.9644 |    0.6939 |     2.014 |
-#> |    F| Forward Diff. |     9.716 |     1.206 |    0.2113 |   -0.1128 |
-#> |.....................|    0.3755 |     1.207 |    -5.399 |     3.226 |
-#> |.....................|  -0.09670 |  -0.03459 |   -0.6713 |   -0.5638 |
-#> |.....................|     1.619 |     1.687 |    0.2005 |    -1.998 |
-#> |   63|     474.14509 |     1.003 |    -1.171 |   -0.9248 |   -0.9363 |
-#> |.....................|    -1.012 |    -1.000 |    0.1105 |   -0.8061 |
-#> |.....................|   -0.7602 |   -0.8822 |   -0.7900 |    -1.087 |
-#> |.....................|   -0.5333 |   -0.8621 |    -1.071 |   -0.2068 |
-#> |    U|     474.14509 |     91.25 |    -5.371 |   -0.9028 |    -2.199 |
-#> |.....................|    -4.624 |    0.4059 |     1.239 |   0.06045 |
-#> |.....................|    0.8775 |   0.05825 |    0.7945 |    0.7106 |
-#> |.....................|     1.579 |    0.9649 |    0.6936 |     2.015 |
-#> |    X|     474.14509 |     91.25 |  0.004648 |    0.2885 |    0.1110 |
-#> |.....................|  0.009811 |    0.6001 |     1.239 |   0.06045 |
-#> |.....................|    0.8775 |   0.05825 |    0.7945 |    0.7106 |
-#> |.....................|     1.579 |    0.9649 |    0.6936 |     2.015 |
-#> |    F| Forward Diff. |    -5.280 |     1.192 |   0.02321 |  -0.09129 |
-#> |.....................|    0.3799 |     1.239 |    -5.339 |     3.156 |
-#> |.....................|   -0.1074 |   0.06181 |   -0.4875 |    -2.680 |
-#> |.....................|     1.648 |     1.743 |    0.2195 |    -1.955 |
-#> |   64|     474.11542 |     1.005 |    -1.172 |   -0.9248 |   -0.9361 |
-#> |.....................|    -1.012 |    -1.001 |    0.1146 |   -0.8089 |
-#> |.....................|   -0.7603 |   -0.8821 |   -0.7897 |    -1.086 |
-#> |.....................|   -0.5344 |   -0.8621 |    -1.071 |   -0.2057 |
-#> |    U|     474.11542 |     91.42 |    -5.372 |   -0.9028 |    -2.199 |
-#> |.....................|    -4.625 |    0.4054 |     1.241 |   0.06037 |
-#> |.....................|    0.8774 |   0.05825 |    0.7947 |    0.7110 |
-#> |.....................|     1.577 |    0.9649 |    0.6934 |     2.017 |
-#> |    X|     474.11542 |     91.42 |  0.004643 |    0.2885 |    0.1110 |
-#> |.....................|  0.009807 |    0.6000 |     1.241 |   0.06037 |
-#> |.....................|    0.8774 |   0.05825 |    0.7947 |    0.7110 |
-#> |.....................|     1.577 |    0.9649 |    0.6934 |     2.017 |
-#> |    F| Forward Diff. |     10.52 |     1.202 |    0.2258 |   -0.1162 |
-#> |.....................|    0.3725 |     1.186 |    -5.381 |     3.222 |
-#> |.....................|   -0.1104 |  -0.04157 |   -0.6550 |   -0.5841 |
-#> |.....................|     1.505 |     1.701 |    0.1753 |    -1.993 |
-#> |   65|     474.07794 |     1.003 |    -1.173 |   -0.9248 |   -0.9360 |
-#> |.....................|    -1.012 |    -1.002 |    0.1187 |   -0.8117 |
-#> |.....................|   -0.7604 |   -0.8821 |   -0.7895 |    -1.087 |
-#> |.....................|   -0.5355 |   -0.8615 |    -1.071 |   -0.2048 |
-#> |    U|     474.07794 |     91.25 |    -5.373 |   -0.9028 |    -2.198 |
-#> |.....................|    -4.625 |    0.4048 |     1.242 |   0.06029 |
-#> |.....................|    0.8774 |   0.05825 |    0.7949 |    0.7104 |
-#> |.....................|     1.576 |    0.9655 |    0.6932 |     2.018 |
-#> |    X|     474.07794 |     91.25 |  0.004638 |    0.2885 |    0.1110 |
-#> |.....................|  0.009804 |    0.5999 |     1.242 |   0.06029 |
-#> |.....................|    0.8774 |   0.05825 |    0.7949 |    0.7104 |
-#> |.....................|     1.576 |    0.9655 |    0.6932 |     2.018 |
-#> |    F| Forward Diff. |    -4.801 |     1.188 |   0.03689 |  -0.09236 |
-#> |.....................|    0.3785 |     1.221 |    -5.368 |     3.104 |
-#> |.....................|   -0.1066 |  0.003449 |   -0.6711 |   -0.7398 |
-#> |.....................|     1.563 |     1.803 |    0.1884 |    -1.939 |
-#> |   66|     474.04951 |     1.005 |    -1.175 |   -0.9248 |   -0.9359 |
-#> |.....................|    -1.013 |    -1.003 |    0.1228 |   -0.8144 |
-#> |.....................|   -0.7604 |   -0.8820 |   -0.7890 |    -1.087 |
-#> |.....................|   -0.5367 |   -0.8618 |    -1.071 |   -0.2036 |
-#> |    U|     474.04951 |     91.43 |    -5.375 |   -0.9028 |    -2.198 |
-#> |.....................|    -4.625 |    0.4044 |     1.244 |   0.06021 |
-#> |.....................|    0.8774 |   0.05825 |    0.7952 |    0.7100 |
-#> |.....................|     1.575 |    0.9652 |    0.6930 |     2.019 |
-#> |    X|     474.04951 |     91.43 |  0.004633 |    0.2885 |    0.1110 |
-#> |.....................|  0.009801 |    0.5997 |     1.244 |   0.06021 |
-#> |.....................|    0.8774 |   0.05825 |    0.7952 |    0.7100 |
-#> |.....................|     1.575 |    0.9652 |    0.6930 |     2.019 |
-#> |    F| Forward Diff. |     10.86 |     1.196 |    0.2377 |   -0.1190 |
-#> |.....................|    0.3700 |     1.169 |    -5.399 |     3.259 |
-#> |.....................|  -0.09645 |  -0.03914 |   -0.4400 |    -2.610 |
-#> |.....................|     1.421 |     1.705 |    0.1351 |    -1.978 |
-#> |   67|     474.01246 |     1.003 |    -1.176 |   -0.9249 |   -0.9357 |
-#> |.....................|    -1.013 |    -1.004 |    0.1268 |   -0.8173 |
-#> |.....................|   -0.7606 |   -0.8819 |   -0.7888 |    -1.088 |
-#> |.....................|   -0.5377 |   -0.8613 |    -1.072 |   -0.2028 |
-#> |    U|     474.01246 |     91.25 |    -5.376 |   -0.9029 |    -2.198 |
-#> |.....................|    -4.626 |    0.4039 |     1.246 |   0.06013 |
-#> |.....................|    0.8773 |   0.05825 |    0.7954 |    0.7098 |
-#> |.....................|     1.573 |    0.9657 |    0.6927 |     2.020 |
-#> |    X|     474.01246 |     91.25 |  0.004628 |    0.2885 |    0.1110 |
-#> |.....................|  0.009798 |    0.5996 |     1.246 |   0.06013 |
-#> |.....................|    0.8773 |   0.05825 |    0.7954 |    0.7098 |
-#> |.....................|     1.573 |    0.9657 |    0.6927 |     2.020 |
-#> |    F| Forward Diff. |    -5.724 |     1.179 |   0.03043 |  -0.09493 |
-#> |.....................|    0.3750 |     1.206 |    -5.283 |     3.092 |
-#> |.....................|  -0.09863 |  -0.01543 |   -0.6573 |   -0.7980 |
-#> |.....................|     1.377 |     1.778 |    0.1578 |    -1.944 |
-#> |   68|     473.98155 |     1.005 |    -1.177 |   -0.9249 |   -0.9356 |
-#> |.....................|    -1.013 |    -1.005 |    0.1310 |   -0.8202 |
-#> |.....................|   -0.7607 |   -0.8818 |   -0.7885 |    -1.088 |
-#> |.....................|   -0.5387 |   -0.8611 |    -1.072 |   -0.2018 |
-#> |    U|     473.98155 |     91.42 |    -5.377 |   -0.9029 |    -2.198 |
-#> |.....................|    -4.626 |    0.4034 |     1.247 |   0.06004 |
-#> |.....................|    0.8773 |   0.05826 |    0.7956 |    0.7095 |
-#> |.....................|     1.572 |    0.9659 |    0.6925 |     2.022 |
-#> |    X|     473.98155 |     91.42 |  0.004623 |    0.2885 |    0.1110 |
-#> |.....................|  0.009794 |    0.5995 |     1.247 |   0.06004 |
-#> |.....................|    0.8773 |   0.05826 |    0.7956 |    0.7095 |
-#> |.....................|     1.572 |    0.9659 |    0.6925 |     2.022 |
-#> |    F| Forward Diff. |     9.125 |     1.189 |    0.2215 |   -0.1183 |
-#> |.....................|    0.3680 |     1.157 |    -5.346 |     3.214 |
-#> |.....................|  -0.06695 |  -0.05805 |   -0.6245 |   -0.6678 |
-#> |.....................|     1.365 |     1.770 |   0.07348 |    -1.960 |
-#> |   69|     473.94647 |     1.003 |    -1.178 |   -0.9250 |   -0.9354 |
-#> |.....................|    -1.014 |    -1.007 |    0.1350 |   -0.8231 |
-#> |.....................|   -0.7608 |   -0.8817 |   -0.7881 |    -1.089 |
-#> |.....................|   -0.5397 |   -0.8608 |    -1.072 |   -0.2009 |
-#> |    U|     473.94647 |     91.26 |    -5.378 |   -0.9030 |    -2.198 |
-#> |.....................|    -4.626 |    0.4029 |     1.249 |   0.05996 |
-#> |.....................|    0.8772 |   0.05826 |    0.7959 |    0.7086 |
-#> |.....................|     1.571 |    0.9661 |    0.6923 |     2.023 |
-#> |    X|     473.94647 |     91.26 |  0.004618 |    0.2884 |    0.1110 |
-#> |.....................|  0.009791 |    0.5994 |     1.249 |   0.05996 |
-#> |.....................|    0.8772 |   0.05826 |    0.7959 |    0.7086 |
-#> |.....................|     1.571 |    0.9661 |    0.6923 |     2.023 |
-#> |    F| Forward Diff. |    -5.271 |     1.174 |   0.04603 |  -0.09766 |
-#> |.....................|    0.3725 |     1.188 |    -5.320 |     3.084 |
-#> |.....................|  -0.09768 |  -0.01918 |   -0.6378 |   -0.8469 |
-#> |.....................|     1.360 |     1.825 |   0.08453 |    -1.920 |
-#> |   70|     473.91708 |     1.005 |    -1.179 |   -0.9250 |   -0.9353 |
-#> |.....................|    -1.014 |    -1.008 |    0.1391 |   -0.8259 |
-#> |.....................|   -0.7609 |   -0.8816 |   -0.7877 |    -1.089 |
-#> |.....................|   -0.5408 |   -0.8610 |    -1.072 |   -0.1999 |
-#> |    U|     473.91708 |     91.43 |    -5.379 |   -0.9030 |    -2.198 |
-#> |.....................|    -4.627 |    0.4024 |     1.251 |   0.05988 |
-#> |.....................|    0.8772 |   0.05826 |    0.7962 |    0.7081 |
-#> |.....................|     1.570 |    0.9660 |    0.6921 |     2.024 |
-#> |    X|     473.91708 |     91.43 |  0.004613 |    0.2884 |    0.1111 |
-#> |.....................|  0.009788 |    0.5993 |     1.251 |   0.05988 |
-#> |.....................|    0.8772 |   0.05826 |    0.7962 |    0.7081 |
-#> |.....................|     1.570 |    0.9660 |    0.6921 |     2.024 |
-#> |    F| Forward Diff. |     9.919 |     1.183 |    0.2388 |   -0.1221 |
-#> |.....................|    0.3649 |     1.138 |    -5.295 |     3.201 |
-#> |.....................|  -0.05759 |  -0.06746 |   -0.6018 |   -0.7458 |
-#> |.....................|     1.218 |     1.797 |   0.02666 |    -1.950 |
-#> |   71|     473.88166 |     1.003 |    -1.180 |   -0.9251 |   -0.9351 |
-#> |.....................|    -1.014 |    -1.009 |    0.1432 |   -0.8289 |
-#> |.....................|   -0.7611 |   -0.8814 |   -0.7874 |    -1.090 |
-#> |.....................|   -0.5418 |   -0.8607 |    -1.072 |   -0.1991 |
-#> |    U|     473.88166 |     91.26 |    -5.380 |   -0.9031 |    -2.198 |
-#> |.....................|    -4.627 |    0.4019 |     1.252 |   0.05979 |
-#> |.....................|    0.8771 |   0.05827 |    0.7964 |    0.7073 |
-#> |.....................|     1.568 |    0.9662 |    0.6919 |     2.025 |
-#> |    X|     473.88166 |     91.26 |  0.004608 |    0.2884 |    0.1111 |
-#> |.....................|  0.009785 |    0.5991 |     1.252 |   0.05979 |
-#> |.....................|    0.8771 |   0.05827 |    0.7964 |    0.7073 |
-#> |.....................|     1.568 |    0.9662 |    0.6919 |     2.025 |
-#> |    F| Forward Diff. |    -5.370 |     1.167 |   0.05346 |  -0.09978 |
-#> |.....................|    0.3701 |     1.174 |    -5.172 |     3.105 |
-#> |.....................|  -0.07011 |  -0.02516 |   -0.4239 |    -2.943 |
-#> |.....................|     1.187 |     1.854 |   0.07395 |    -1.907 |
-#> |   72|     473.85215 |     1.005 |    -1.181 |   -0.9251 |   -0.9350 |
-#> |.....................|    -1.015 |    -1.010 |    0.1472 |   -0.8318 |
-#> |.....................|   -0.7612 |   -0.8813 |   -0.7872 |    -1.090 |
-#> |.....................|   -0.5427 |   -0.8608 |    -1.073 |   -0.1983 |
-#> |    U|     473.85215 |     91.44 |    -5.381 |   -0.9031 |    -2.197 |
-#> |.....................|    -4.627 |    0.4014 |     1.254 |   0.05971 |
-#> |.....................|    0.8771 |   0.05827 |    0.7965 |    0.7078 |
-#> |.....................|     1.567 |    0.9662 |    0.6918 |     2.026 |
-#> |    X|     473.85215 |     91.44 |  0.004603 |    0.2884 |    0.1111 |
-#> |.....................|  0.009781 |    0.5990 |     1.254 |   0.05971 |
-#> |.....................|    0.8771 |   0.05827 |    0.7965 |    0.7078 |
-#> |.....................|     1.567 |    0.9662 |    0.6918 |     2.026 |
-#> |    F| Forward Diff. |     10.42 |     1.179 |    0.2474 |   -0.1240 |
-#> |.....................|    0.3627 |     1.120 |    -5.345 |     3.221 |
-#> |.....................|  -0.07960 |  -0.04998 |   -0.3836 |    -2.755 |
-#> |.....................|     1.094 |     1.797 |  -0.01014 |    -1.939 |
-#> |   73|     473.81514 |     1.003 |    -1.182 |   -0.9251 |   -0.9348 |
-#> |.....................|    -1.015 |    -1.011 |    0.1513 |   -0.8349 |
-#> |.....................|   -0.7614 |   -0.8810 |   -0.7873 |    -1.089 |
-#> |.....................|   -0.5432 |   -0.8601 |    -1.073 |   -0.1979 |
-#> |    U|     473.81514 |     91.27 |    -5.382 |   -0.9031 |    -2.197 |
-#> |.....................|    -4.628 |    0.4008 |     1.256 |   0.05962 |
-#> |.....................|    0.8770 |   0.05828 |    0.7964 |    0.7084 |
-#> |.....................|     1.567 |    0.9669 |    0.6916 |     2.026 |
-#> |    X|     473.81514 |     91.27 |  0.004598 |    0.2884 |    0.1111 |
-#> |.....................|  0.009778 |    0.5989 |     1.256 |   0.05962 |
-#> |.....................|    0.8770 |   0.05828 |    0.7964 |    0.7084 |
-#> |.....................|     1.567 |    0.9669 |    0.6916 |     2.026 |
-#> |    F| Forward Diff. |    -4.811 |     1.166 |   0.05684 |   -0.1019 |
-#> |.....................|    0.3663 |     1.150 |    -5.276 |     3.057 |
-#> |.....................|  -0.06818 |  -0.03474 |   -0.4125 |    -2.836 |
-#> |.....................|     1.158 |     1.851 |   0.03258 |    -1.914 |
-#> |   74|     473.78884 |     1.005 |    -1.183 |   -0.9252 |   -0.9346 |
-#> |.....................|    -1.015 |    -1.012 |    0.1554 |   -0.8377 |
-#> |.....................|   -0.7615 |   -0.8808 |   -0.7873 |    -1.088 |
-#> |.....................|   -0.5439 |   -0.8602 |    -1.073 |   -0.1971 |
-#> |    U|     473.78884 |     91.46 |    -5.383 |   -0.9031 |    -2.197 |
-#> |.....................|    -4.628 |    0.4003 |     1.257 |   0.05954 |
-#> |.....................|    0.8770 |   0.05829 |    0.7965 |    0.7095 |
-#> |.....................|     1.566 |    0.9667 |    0.6915 |     2.027 |
-#> |    X|     473.78884 |     91.46 |  0.004593 |    0.2884 |    0.1111 |
-#> |.....................|  0.009775 |    0.5988 |     1.257 |   0.05954 |
-#> |.....................|    0.8770 |   0.05829 |    0.7965 |    0.7095 |
-#> |.....................|     1.566 |    0.9667 |    0.6915 |     2.027 |
-#> |    F| Forward Diff. |     12.26 |     1.178 |    0.2628 |   -0.1282 |
-#> |.....................|    0.3579 |     1.094 |    -5.180 |     3.234 |
-#> |.....................|  -0.08932 |  -0.09780 |   -0.5652 |   -0.6340 |
-#> |.....................|     1.031 |     1.841 |  -0.06209 |    -1.938 |
-#> |   75|     473.75065 |     1.003 |    -1.184 |   -0.9252 |   -0.9344 |
-#> |.....................|    -1.016 |    -1.013 |    0.1594 |   -0.8407 |
-#> |.....................|   -0.7617 |   -0.8806 |   -0.7872 |    -1.088 |
-#> |.....................|   -0.5446 |   -0.8597 |    -1.073 |   -0.1966 |
-#> |    U|     473.75065 |     91.27 |    -5.384 |   -0.9032 |    -2.197 |
-#> |.....................|    -4.628 |    0.3998 |     1.259 |   0.05945 |
-#> |.....................|    0.8769 |   0.05829 |    0.7965 |    0.7092 |
-#> |.....................|     1.565 |    0.9672 |    0.6914 |     2.028 |
-#> |    X|     473.75065 |     91.27 |  0.004588 |    0.2884 |    0.1112 |
-#> |.....................|  0.009772 |    0.5986 |     1.259 |   0.05945 |
-#> |.....................|    0.8769 |   0.05829 |    0.7965 |    0.7092 |
-#> |.....................|     1.565 |    0.9672 |    0.6914 |     2.028 |
-#> |    F| Forward Diff. |    -5.250 |     1.164 |   0.05078 |   -0.1019 |
-#> |.....................|    0.3635 |     1.132 |    -5.308 |     3.057 |
-#> |.....................|  -0.09569 |  -0.05602 |   -0.5891 |   -0.8121 |
-#> |.....................|     1.074 |     1.883 |  0.002586 |    -1.906 |
-#> |   76|     473.72028 |     1.005 |    -1.185 |   -0.9252 |   -0.9343 |
-#> |.....................|    -1.016 |    -1.014 |    0.1635 |   -0.8437 |
-#> |.....................|   -0.7618 |   -0.8804 |   -0.7870 |    -1.089 |
-#> |.....................|   -0.5455 |   -0.8599 |    -1.073 |   -0.1958 |
-#> |    U|     473.72028 |     91.43 |    -5.385 |   -0.9032 |    -2.197 |
-#> |.....................|    -4.629 |    0.3993 |     1.261 |   0.05936 |
-#> |.....................|    0.8768 |   0.05830 |    0.7967 |    0.7088 |
-#> |.....................|     1.564 |    0.9671 |    0.6912 |     2.029 |
-#> |    X|     473.72028 |     91.43 |  0.004583 |    0.2884 |    0.1112 |
-#> |.....................|  0.009768 |    0.5985 |     1.261 |   0.05936 |
-#> |.....................|    0.8768 |   0.05830 |    0.7967 |    0.7088 |
-#> |.....................|     1.564 |    0.9671 |    0.6912 |     2.029 |
-#> |    F| Forward Diff. |     8.975 |     1.171 |    0.2290 |   -0.1246 |
-#> |.....................|    0.3563 |     1.085 |    -5.320 |     3.173 |
-#> |.....................|  -0.08707 |   -0.1016 |   -0.5561 |   -0.7117 |
-#> |.....................|    0.9536 |     1.850 |  -0.07963 |    -1.922 |
-#> |   77|     473.68600 |     1.003 |    -1.186 |   -0.9253 |   -0.9341 |
-#> |.....................|    -1.016 |    -1.015 |    0.1676 |   -0.8467 |
-#> |.....................|   -0.7620 |   -0.8801 |   -0.7868 |    -1.089 |
-#> |.....................|   -0.5463 |   -0.8596 |    -1.073 |   -0.1952 |
-#> |    U|       473.686 |     91.28 |    -5.386 |   -0.9033 |    -2.196 |
-#> |.....................|    -4.629 |    0.3989 |     1.263 |   0.05928 |
-#> |.....................|    0.8768 |   0.05831 |    0.7968 |    0.7081 |
-#> |.....................|     1.563 |    0.9673 |    0.6911 |     2.030 |
-#> |    X|       473.686 |     91.28 |  0.004578 |    0.2884 |    0.1112 |
-#> |.....................|  0.009765 |    0.5984 |     1.263 |   0.05928 |
-#> |.....................|    0.8768 |   0.05831 |    0.7968 |    0.7081 |
-#> |.....................|     1.563 |    0.9673 |    0.6911 |     2.030 |
-#> |    F| Forward Diff. |    -5.608 |     1.155 |   0.05506 |   -0.1036 |
-#> |.....................|    0.3607 |     1.118 |    -5.212 |     3.031 |
-#> |.....................|  -0.08611 |  -0.04336 |   -0.3798 |    -2.808 |
-#> |.....................|     1.093 |     1.880 |  -0.02731 |    -1.896 |
-#> |   78|     473.65599 |     1.005 |    -1.188 |   -0.9253 |   -0.9339 |
-#> |.....................|    -1.017 |    -1.016 |    0.1718 |   -0.8497 |
-#> |.....................|   -0.7621 |   -0.8799 |   -0.7868 |    -1.089 |
-#> |.....................|   -0.5471 |   -0.8595 |    -1.074 |   -0.1946 |
-#> |    U|     473.65599 |     91.44 |    -5.388 |   -0.9033 |    -2.196 |
-#> |.....................|    -4.629 |    0.3984 |     1.264 |   0.05919 |
-#> |.....................|    0.8767 |   0.05831 |    0.7968 |    0.7087 |
-#> |.....................|     1.562 |    0.9674 |    0.6910 |     2.030 |
-#> |    X|     473.65599 |     91.44 |  0.004573 |    0.2884 |    0.1112 |
-#> |.....................|  0.009762 |    0.5983 |     1.264 |   0.05919 |
-#> |.....................|    0.8767 |   0.05831 |    0.7968 |    0.7087 |
-#> |.....................|     1.562 |    0.9674 |    0.6910 |     2.030 |
-#> |    F| Forward Diff. |     9.720 |     1.170 |    0.2444 |   -0.1229 |
-#> |.....................|    0.3557 |     1.067 |    -5.275 |     3.173 |
-#> |.....................|  -0.07850 |   -0.1042 |   -0.5348 |   -0.6844 |
-#> |.....................|    0.9479 |     1.915 |   -0.1018 |    -1.917 |
-#> |   79|     473.62083 |     1.003 |    -1.189 |   -0.9254 |   -0.9337 |
-#> |.....................|    -1.017 |    -1.017 |    0.1759 |   -0.8528 |
-#> |.....................|   -0.7623 |   -0.8795 |   -0.7869 |    -1.089 |
-#> |.....................|   -0.5477 |   -0.8591 |    -1.074 |   -0.1942 |
-#> |    U|     473.62083 |     91.28 |    -5.389 |   -0.9033 |    -2.196 |
-#> |.....................|    -4.630 |    0.3979 |     1.266 |   0.05910 |
-#> |.....................|    0.8766 |   0.05832 |    0.7968 |    0.7085 |
-#> |.....................|     1.562 |    0.9678 |    0.6909 |     2.031 |
-#> |    X|     473.62083 |     91.28 |  0.004568 |    0.2884 |    0.1112 |
-#> |.....................|  0.009758 |    0.5982 |     1.266 |   0.05910 |
-#> |.....................|    0.8766 |   0.05832 |    0.7968 |    0.7085 |
-#> |.....................|     1.562 |    0.9678 |    0.6909 |     2.031 |
-#> |    F| Forward Diff. |    -5.323 |     1.153 |   0.05982 |   -0.1053 |
-#> |.....................|    0.3572 |     1.098 |    -4.702 |     3.058 |
-#> |.....................|   -0.1117 |  -0.04281 |   -0.5573 |   -0.7999 |
-#> |.....................|     1.039 |     1.912 |  -0.05974 |    -1.890 |
-#> |   80|     473.59326 |     1.005 |    -1.190 |   -0.9254 |   -0.9335 |
-#> |.....................|    -1.018 |    -1.019 |    0.1798 |   -0.8560 |
-#> |.....................|   -0.7624 |   -0.8793 |   -0.7867 |    -1.090 |
-#> |.....................|   -0.5486 |   -0.8595 |    -1.074 |   -0.1934 |
-#> |    U|     473.59326 |     91.46 |    -5.390 |   -0.9034 |    -2.196 |
-#> |.....................|    -4.630 |    0.3974 |     1.268 |   0.05901 |
-#> |.....................|    0.8766 |   0.05833 |    0.7969 |    0.7081 |
-#> |.....................|     1.560 |    0.9674 |    0.6908 |     2.032 |
-#> |    X|     473.59326 |     91.46 |  0.004562 |    0.2884 |    0.1113 |
-#> |.....................|  0.009755 |    0.5981 |     1.268 |   0.05901 |
-#> |.....................|    0.8766 |   0.05833 |    0.7969 |    0.7081 |
-#> |.....................|     1.560 |    0.9674 |    0.6908 |     2.032 |
-#> |    F| Forward Diff. |     11.25 |     1.162 |    0.2586 |   -0.1299 |
-#> |.....................|    0.3499 |     1.048 |    -5.229 |     3.126 |
-#> |.....................|  -0.05642 |  -0.09930 |   -0.3252 |    -2.718 |
-#> |.....................|    0.8202 |     1.876 |   -0.1477 |    -1.910 |
-#> |   81|     473.55541 |     1.003 |    -1.191 |   -0.9255 |   -0.9333 |
-#> |.....................|    -1.018 |    -1.020 |    0.1836 |   -0.8595 |
-#> |.....................|   -0.7626 |   -0.8789 |   -0.7868 |    -1.090 |
-#> |.....................|   -0.5492 |   -0.8592 |    -1.074 |   -0.1932 |
-#> |    U|     473.55541 |     91.31 |    -5.391 |   -0.9034 |    -2.196 |
-#> |.....................|    -4.630 |    0.3968 |     1.269 |   0.05891 |
-#> |.....................|    0.8765 |   0.05834 |    0.7968 |    0.7080 |
-#> |.....................|     1.560 |    0.9677 |    0.6906 |     2.032 |
-#> |    X|     473.55541 |     91.31 |  0.004557 |    0.2883 |    0.1113 |
-#> |.....................|  0.009751 |    0.5979 |     1.269 |   0.05891 |
-#> |.....................|    0.8765 |   0.05834 |    0.7968 |    0.7080 |
-#> |.....................|     1.560 |    0.9677 |    0.6906 |     2.032 |
-#> |    F| Forward Diff. |    -3.062 |     1.149 |   0.09224 |   -0.1103 |
-#> |.....................|    0.3525 |     1.070 |    -5.098 |     2.994 |
-#> |.....................|   -0.1095 |  -0.04877 |   -0.3504 |    -2.828 |
-#> |.....................|    0.8255 |     1.898 |   -0.1147 |    -1.889 |
-#> |   82|     473.53708 |     1.006 |    -1.192 |   -0.9256 |   -0.9332 |
-#> |.....................|    -1.018 |    -1.021 |    0.1873 |   -0.8616 |
-#> |.....................|   -0.7625 |   -0.8789 |   -0.7866 |    -1.087 |
-#> |.....................|   -0.5498 |   -0.8606 |    -1.074 |   -0.1918 |
-#> |    U|     473.53708 |     91.52 |    -5.392 |   -0.9035 |    -2.196 |
-#> |.....................|    -4.631 |    0.3964 |     1.271 |   0.05884 |
-#> |.....................|    0.8765 |   0.05834 |    0.7970 |    0.7099 |
-#> |.....................|     1.559 |    0.9664 |    0.6907 |     2.034 |
-#> |    X|     473.53708 |     91.52 |  0.004553 |    0.2883 |    0.1113 |
-#> |.....................|  0.009749 |    0.5978 |     1.271 |   0.05884 |
-#> |.....................|    0.8765 |   0.05834 |    0.7970 |    0.7099 |
-#> |.....................|     1.559 |    0.9664 |    0.6907 |     2.034 |
-#> |    F| Forward Diff. |     16.25 |     1.165 |    0.3077 |   -0.1378 |
-#> |.....................|    0.3448 |     1.019 |    -5.264 |     3.150 |
-#> |.....................|  -0.09278 |   -0.1366 |   -0.2969 |    -2.557 |
-#> |.....................|    0.7485 |     1.781 |   -0.1828 |    -1.909 |
-#> |   83|     473.49312 |     1.003 |    -1.193 |   -0.9256 |   -0.9329 |
-#> |.....................|    -1.018 |    -1.022 |    0.1912 |   -0.8647 |
-#> |.....................|   -0.7626 |   -0.8785 |   -0.7869 |    -1.087 |
-#> |.....................|   -0.5501 |   -0.8598 |    -1.074 |   -0.1918 |
-#> |    U|     473.49312 |     91.32 |    -5.393 |   -0.9035 |    -2.195 |
-#> |.....................|    -4.631 |    0.3959 |     1.272 |   0.05875 |
-#> |.....................|    0.8765 |   0.05835 |    0.7967 |    0.7106 |
-#> |.....................|     1.559 |    0.9671 |    0.6906 |     2.034 |
-#> |    X|     473.49312 |     91.32 |  0.004547 |    0.2883 |    0.1113 |
-#> |.....................|  0.009745 |    0.5977 |     1.272 |   0.05875 |
-#> |.....................|    0.8765 |   0.05835 |    0.7967 |    0.7106 |
-#> |.....................|     1.559 |    0.9671 |    0.6906 |     2.034 |
-#> |    F| Forward Diff. |    -2.793 |     1.150 |   0.08391 |   -0.1095 |
-#> |.....................|    0.3500 |     1.057 |    -5.154 |     2.847 |
-#> |.....................|  -0.07414 |  -0.06025 |   -0.5244 |   -0.6779 |
-#> |.....................|    0.8291 |     1.867 |   -0.1201 |    -1.880 |
-#> |   84|     473.47390 |     1.006 |    -1.194 |   -0.9256 |   -0.9329 |
-#> |.....................|    -1.019 |    -1.022 |    0.1953 |   -0.8670 |
-#> |.....................|   -0.7626 |   -0.8785 |   -0.7865 |    -1.086 |
-#> |.....................|   -0.5507 |   -0.8613 |    -1.074 |   -0.1903 |
-#> |    U|      473.4739 |     91.52 |    -5.394 |   -0.9036 |    -2.195 |
-#> |.....................|    -4.631 |    0.3955 |     1.274 |   0.05869 |
-#> |.....................|    0.8765 |   0.05835 |    0.7970 |    0.7110 |
-#> |.....................|     1.558 |    0.9657 |    0.6907 |     2.036 |
-#> |    X|      473.4739 |     91.52 |  0.004543 |    0.2883 |    0.1113 |
-#> |.....................|  0.009743 |    0.5976 |     1.274 |   0.05869 |
-#> |.....................|    0.8765 |   0.05835 |    0.7970 |    0.7110 |
-#> |.....................|     1.558 |    0.9657 |    0.6907 |     2.036 |
-#> |    F| Forward Diff. |     15.82 |     1.163 |    0.3026 |   -0.1376 |
-#> |.....................|    0.3423 |     1.007 |    -4.821 |     3.176 |
-#> |.....................|  -0.06207 |   -0.1161 |   -0.4712 |   -0.4774 |
-#> |.....................|    0.7015 |     1.725 |   -0.1877 |    -1.896 |
-#> |   85|     473.43080 |     1.003 |    -1.195 |   -0.9257 |   -0.9326 |
-#> |.....................|    -1.019 |    -1.024 |    0.1991 |   -0.8700 |
-#> |.....................|   -0.7628 |   -0.8781 |   -0.7866 |    -1.087 |
-#> |.....................|   -0.5513 |   -0.8608 |    -1.074 |   -0.1899 |
-#> |    U|      473.4308 |     91.31 |    -5.395 |   -0.9036 |    -2.195 |
-#> |.....................|    -4.632 |    0.3950 |     1.276 |   0.05860 |
-#> |.....................|    0.8764 |   0.05836 |    0.7970 |    0.7105 |
-#> |.....................|     1.557 |    0.9662 |    0.6906 |     2.036 |
-#> |    X|      473.4308 |     91.31 |  0.004538 |    0.2883 |    0.1114 |
-#> |.....................|  0.009739 |    0.5975 |     1.276 |   0.05860 |
-#> |.....................|    0.8764 |   0.05836 |    0.7970 |    0.7105 |
-#> |.....................|     1.557 |    0.9662 |    0.6906 |     2.036 |
-#> |    F| Forward Diff. |    -3.611 |     1.145 |   0.07564 |   -0.1091 |
-#> |.....................|    0.3478 |     1.048 |    -5.196 |     2.853 |
-#> |.....................|  -0.07176 |  -0.06153 |   -0.5100 |   -0.6862 |
-#> |.....................|    0.7701 |     1.783 |   -0.1204 |    -1.866 |
-#> |   86|     473.40390 |     1.005 |    -1.196 |   -0.9258 |   -0.9324 |
-#> |.....................|    -1.019 |    -1.025 |    0.2034 |   -0.8728 |
-#> |.....................|   -0.7629 |   -0.8779 |   -0.7864 |    -1.087 |
-#> |.....................|   -0.5520 |   -0.8612 |    -1.074 |   -0.1890 |
-#> |    U|      473.4039 |     91.48 |    -5.396 |   -0.9037 |    -2.195 |
-#> |.....................|    -4.632 |    0.3946 |     1.277 |   0.05852 |
-#> |.....................|    0.8764 |   0.05837 |    0.7971 |    0.7105 |
-#> |.....................|     1.556 |    0.9658 |    0.6906 |     2.037 |
-#> |    X|      473.4039 |     91.48 |  0.004533 |    0.2883 |    0.1114 |
-#> |.....................|  0.009736 |    0.5974 |     1.277 |   0.05852 |
-#> |.....................|    0.8764 |   0.05837 |    0.7971 |    0.7105 |
-#> |.....................|     1.556 |    0.9658 |    0.6906 |     2.037 |
-#> |    F| Forward Diff. |     11.82 |     1.154 |    0.2542 |   -0.1321 |
-#> |.....................|    0.3410 |     1.002 |    -5.150 |     3.097 |
-#> |.....................|  -0.04820 |   -0.1059 |   -0.4698 |   -0.5387 |
-#> |.....................|    0.6891 |     1.733 |   -0.1906 |    -1.879 |
-#> |   87|     473.36686 |     1.003 |    -1.198 |   -0.9258 |   -0.9322 |
-#> |.....................|    -1.020 |    -1.026 |    0.2076 |   -0.8758 |
-#> |.....................|   -0.7631 |   -0.8776 |   -0.7865 |    -1.087 |
-#> |.....................|   -0.5525 |   -0.8606 |    -1.074 |   -0.1886 |
-#> |    U|     473.36686 |     91.32 |    -5.398 |   -0.9037 |    -2.195 |
-#> |.....................|    -4.632 |    0.3941 |     1.279 |   0.05843 |
-#> |.....................|    0.8763 |   0.05838 |    0.7970 |    0.7100 |
-#> |.....................|     1.556 |    0.9664 |    0.6905 |     2.038 |
-#> |    X|     473.36686 |     91.32 |  0.004527 |    0.2883 |    0.1114 |
-#> |.....................|  0.009733 |    0.5973 |     1.279 |   0.05843 |
-#> |.....................|    0.8763 |   0.05838 |    0.7970 |    0.7100 |
-#> |.....................|     1.556 |    0.9664 |    0.6905 |     2.038 |
-#> |    F| Forward Diff. |    -3.686 |     1.139 |   0.08028 |   -0.1103 |
-#> |.....................|    0.3450 |     1.034 |    -5.059 |     2.983 |
-#> |.....................|  -0.07022 |  -0.06541 |   -0.4954 |   -0.7148 |
-#> |.....................|    0.6839 |     1.782 |   -0.1353 |    -1.853 |
-#> |   88|     473.34117 |     1.005 |    -1.199 |   -0.9259 |   -0.9321 |
-#> |.....................|    -1.020 |    -1.027 |    0.2118 |   -0.8787 |
-#> |.....................|   -0.7632 |   -0.8774 |   -0.7864 |    -1.087 |
-#> |.....................|   -0.5531 |   -0.8611 |    -1.074 |   -0.1877 |
-#> |    U|     473.34117 |     91.49 |    -5.399 |   -0.9038 |    -2.194 |
-#> |.....................|    -4.633 |    0.3936 |     1.281 |   0.05835 |
-#> |.....................|    0.8763 |   0.05838 |    0.7971 |    0.7100 |
-#> |.....................|     1.555 |    0.9659 |    0.6904 |     2.039 |
-#> |    X|     473.34117 |     91.49 |  0.004522 |    0.2883 |    0.1114 |
-#> |.....................|  0.009730 |    0.5972 |     1.281 |   0.05835 |
-#> |.....................|    0.8763 |   0.05838 |    0.7971 |    0.7100 |
-#> |.....................|     1.555 |    0.9659 |    0.6904 |     2.039 |
-#> |    F| Forward Diff. |     12.62 |     1.149 |    0.2679 |   -0.1346 |
-#> |.....................|    0.3379 |    0.9875 |    -5.147 |     2.965 |
-#> |.....................|  -0.07400 |   -0.1145 |   -0.4542 |   -0.5455 |
-#> |.....................|    0.6283 |     1.734 |   -0.2097 |    -1.869 |
-#> |   89|     473.30326 |     1.004 |    -1.200 |   -0.9259 |   -0.9318 |
-#> |.....................|    -1.020 |    -1.028 |    0.2159 |   -0.8818 |
-#> |.....................|   -0.7634 |   -0.8771 |   -0.7865 |    -1.088 |
-#> |.....................|   -0.5535 |   -0.8604 |    -1.074 |   -0.1874 |
-#> |    U|     473.30326 |     91.32 |    -5.400 |   -0.9038 |    -2.194 |
-#> |.....................|    -4.633 |    0.3932 |     1.283 |   0.05826 |
-#> |.....................|    0.8762 |   0.05839 |    0.7970 |    0.7096 |
-#> |.....................|     1.555 |    0.9665 |    0.6903 |     2.039 |
-#> |    X|     473.30326 |     91.32 |  0.004517 |    0.2883 |    0.1114 |
-#> |.....................|  0.009726 |    0.5970 |     1.283 |   0.05826 |
-#> |.....................|    0.8762 |   0.05839 |    0.7970 |    0.7096 |
-#> |.....................|     1.555 |    0.9665 |    0.6903 |     2.039 |
-#> |    F| Forward Diff. |    -3.609 |     1.134 |   0.08636 |   -0.1114 |
-#> |.....................|    0.3423 |     1.018 |    -5.228 |     2.880 |
-#> |.....................|   -0.1079 |  -0.06580 |   -0.2896 |    -2.686 |
-#> |.....................|    0.6917 |     1.801 |   -0.1599 |    -1.842 |
-#> |   90|     473.27616 |     1.005 |    -1.201 |   -0.9260 |   -0.9316 |
-#> |.....................|    -1.021 |    -1.029 |    0.2202 |   -0.8845 |
-#> |.....................|   -0.7634 |   -0.8768 |   -0.7866 |    -1.087 |
-#> |.....................|   -0.5540 |   -0.8607 |    -1.074 |   -0.1867 |
-#> |    U|     473.27616 |     91.48 |    -5.401 |   -0.9039 |    -2.194 |
-#> |.....................|    -4.633 |    0.3927 |     1.284 |   0.05818 |
-#> |.....................|    0.8762 |   0.05840 |    0.7970 |    0.7107 |
-#> |.....................|     1.554 |    0.9663 |    0.6904 |     2.040 |
-#> |    X|     473.27616 |     91.48 |  0.004512 |    0.2883 |    0.1115 |
-#> |.....................|  0.009723 |    0.5969 |     1.284 |   0.05818 |
-#> |.....................|    0.8762 |   0.05840 |    0.7970 |    0.7107 |
-#> |.....................|     1.554 |    0.9663 |    0.6904 |     2.040 |
-#> |    F| Forward Diff. |     11.44 |     1.145 |    0.2516 |   -0.1333 |
-#> |.....................|    0.3351 |    0.9744 |    -4.753 |     3.090 |
-#> |.....................|  -0.05028 |   -0.1148 |   -0.4450 |   -0.5198 |
-#> |.....................|    0.5573 |     1.743 |   -0.2240 |    -1.858 |
-#> |   91|     473.24283 |     1.003 |    -1.202 |   -0.9260 |   -0.9314 |
-#> |.....................|    -1.021 |    -1.030 |    0.2240 |   -0.8877 |
-#> |.....................|   -0.7636 |   -0.8764 |   -0.7870 |    -1.087 |
-#> |.....................|   -0.5543 |   -0.8601 |    -1.074 |   -0.1866 |
-#> |    U|     473.24283 |     91.29 |    -5.402 |   -0.9039 |    -2.194 |
-#> |.....................|    -4.634 |    0.3922 |     1.286 |   0.05809 |
-#> |.....................|    0.8761 |   0.05841 |    0.7967 |    0.7107 |
-#> |.....................|     1.554 |    0.9668 |    0.6903 |     2.040 |
-#> |    X|     473.24283 |     91.29 |  0.004506 |    0.2882 |    0.1115 |
-#> |.....................|  0.009720 |    0.5968 |     1.286 |   0.05809 |
-#> |.....................|    0.8761 |   0.05841 |    0.7967 |    0.7107 |
-#> |.....................|     1.554 |    0.9668 |    0.6903 |     2.040 |
-#> |    F| Forward Diff. |    -7.383 |     1.129 |   0.03939 |   -0.1057 |
-#> |.....................|    0.3410 |     1.013 |    -4.733 |     2.907 |
-#> |.....................|  -0.07460 |  -0.06623 |   -0.4732 |   -0.6761 |
-#> |.....................|    0.6495 |     1.823 |   -0.1637 |    -1.832 |
-#> |   92|     473.20973 |     1.005 |    -1.204 |   -0.9260 |   -0.9311 |
-#> |.....................|    -1.021 |    -1.031 |    0.2279 |   -0.8912 |
-#> |.....................|   -0.7638 |   -0.8760 |   -0.7872 |    -1.087 |
-#> |.....................|   -0.5548 |   -0.8600 |    -1.075 |   -0.1862 |
-#> |    U|     473.20973 |     91.43 |    -5.404 |   -0.9039 |    -2.193 |
-#> |.....................|    -4.634 |    0.3917 |     1.288 |   0.05799 |
-#> |.....................|    0.8760 |   0.05843 |    0.7966 |    0.7102 |
-#> |.....................|     1.553 |    0.9669 |    0.6900 |     2.040 |
-#> |    X|     473.20973 |     91.43 |  0.004500 |    0.2882 |    0.1115 |
-#> |.....................|  0.009716 |    0.5967 |     1.288 |   0.05799 |
-#> |.....................|    0.8760 |   0.05843 |    0.7966 |    0.7102 |
-#> |.....................|     1.553 |    0.9669 |    0.6900 |     2.040 |
-#> |   93|     473.17178 |     1.005 |    -1.205 |   -0.9261 |   -0.9307 |
-#> |.....................|    -1.022 |    -1.032 |    0.2326 |   -0.8959 |
-#> |.....................|   -0.7641 |   -0.8754 |   -0.7876 |    -1.088 |
-#> |.....................|   -0.5554 |   -0.8593 |    -1.075 |   -0.1863 |
-#> |    U|     473.17178 |     91.43 |    -5.405 |   -0.9040 |    -2.193 |
-#> |.....................|    -4.634 |    0.3910 |     1.289 |   0.05785 |
-#> |.....................|    0.8759 |   0.05844 |    0.7963 |    0.7092 |
-#> |.....................|     1.552 |    0.9676 |    0.6896 |     2.040 |
-#> |    X|     473.17178 |     91.43 |  0.004492 |    0.2882 |    0.1116 |
-#> |.....................|  0.009711 |    0.5965 |     1.289 |   0.05785 |
-#> |.....................|    0.8759 |   0.05844 |    0.7963 |    0.7092 |
-#> |.....................|     1.552 |    0.9676 |    0.6896 |     2.040 |
-#> |   94|     472.97479 |     1.005 |    -1.215 |   -0.9262 |   -0.9287 |
-#> |.....................|    -1.025 |    -1.041 |    0.2575 |   -0.9212 |
-#> |.....................|   -0.7657 |   -0.8720 |   -0.7899 |    -1.094 |
-#> |.....................|   -0.5585 |   -0.8552 |    -1.078 |   -0.1866 |
-#> |    U|     472.97479 |     91.45 |    -5.415 |   -0.9041 |    -2.191 |
-#> |.....................|    -4.637 |    0.3872 |     1.300 |   0.05712 |
-#> |.....................|    0.8752 |   0.05854 |    0.7946 |    0.7037 |
-#> |.....................|     1.549 |    0.9715 |    0.6874 |     2.040 |
-#> |    X|     472.97479 |     91.45 |  0.004449 |    0.2882 |    0.1118 |
-#> |.....................|  0.009685 |    0.5956 |     1.300 |   0.05712 |
-#> |.....................|    0.8752 |   0.05854 |    0.7946 |    0.7037 |
-#> |.....................|     1.549 |    0.9715 |    0.6874 |     2.040 |
-#> |   95|     472.26932 |     1.006 |    -1.253 |   -0.9268 |   -0.9205 |
-#> |.....................|    -1.035 |    -1.074 |    0.3572 |    -1.022 |
-#> |.....................|   -0.7723 |   -0.8583 |   -0.7991 |    -1.118 |
-#> |.....................|   -0.5709 |   -0.8392 |    -1.088 |   -0.1877 |
-#> |    U|     472.26932 |     91.55 |    -5.453 |   -0.9046 |    -2.183 |
-#> |.....................|    -4.648 |    0.3719 |     1.341 |   0.05419 |
-#> |.....................|    0.8725 |   0.05894 |    0.7878 |    0.6819 |
-#> |.....................|     1.534 |    0.9868 |    0.6787 |     2.039 |
-#> |    X|     472.26932 |     91.55 |  0.004282 |    0.2881 |    0.1127 |
-#> |.....................|  0.009582 |    0.5919 |     1.341 |   0.05419 |
-#> |.....................|    0.8725 |   0.05894 |    0.7878 |    0.6819 |
-#> |.....................|     1.534 |    0.9868 |    0.6787 |     2.039 |
-#> |   96|     470.90347 |     1.012 |    -1.408 |   -0.9286 |   -0.8872 |
-#> |.....................|    -1.078 |    -1.207 |    0.7550 |    -1.427 |
-#> |.....................|   -0.7985 |   -0.8024 |   -0.8343 |    -1.204 |
-#> |.....................|   -0.6170 |   -0.7722 |    -1.128 |   -0.1957 |
-#> |    U|     470.90347 |     92.06 |    -5.608 |   -0.9062 |    -2.150 |
-#> |.....................|    -4.691 |    0.3105 |     1.506 |   0.04245 |
-#> |.....................|    0.8616 |   0.06056 |    0.7621 |    0.6043 |
-#> |.....................|     1.480 |     1.051 |    0.6438 |     2.029 |
-#> |    X|     470.90347 |     92.06 |  0.003670 |    0.2878 |    0.1165 |
-#> |.....................|  0.009180 |    0.5770 |     1.506 |   0.04245 |
-#> |.....................|    0.8616 |   0.06056 |    0.7621 |    0.6043 |
-#> |.....................|     1.480 |     1.051 |    0.6438 |     2.029 |
-#> |    F| Forward Diff. |     16.46 |    0.7178 |     1.137 |   -0.2842 |
-#> |.....................|   0.06515 |    -1.058 |    -6.810 |    -2.325 |
-#> |.....................|   -0.1903 |   -0.6630 |     1.424 |    -9.046 |
-#> |.....................|    -1.659 |     8.235 |    -7.307 |    -1.506 |
-#> |   97|     469.55066 |     1.016 |    -1.623 |   -0.9529 |   -0.8214 |
-#> |.....................|    -1.136 |    -1.353 |     1.295 |    -1.874 |
-#> |.....................|   -0.8595 |   -0.6716 |   -0.9513 |    -1.204 |
-#> |.....................|   -0.7087 |   -0.8316 |   -0.9499 |   -0.4083 |
-#> |    U|     469.55066 |     92.47 |    -5.823 |   -0.9279 |    -2.084 |
-#> |.....................|    -4.749 |    0.2437 |     1.731 |   0.02949 |
-#> |.....................|    0.8363 |   0.06435 |    0.6766 |    0.6043 |
-#> |.....................|     1.371 |    0.9940 |    0.7978 |     1.771 |
-#> |    X|     469.55066 |     92.47 |  0.002960 |    0.2834 |    0.1245 |
-#> |.....................|  0.008661 |    0.5606 |     1.731 |   0.02949 |
-#> |.....................|    0.8363 |   0.06435 |    0.6766 |    0.6043 |
-#> |.....................|     1.371 |    0.9940 |    0.7978 |     1.771 |
-#> |    F| Forward Diff. |    -5.003 |    0.4823 |    0.6025 |   -0.2481 |
-#> |.....................|    -1.135 |    0.1015 |    -5.875 |    -8.309 |
-#> |.....................|   -0.8363 |   -0.7839 |     1.711 |    -6.097 |
-#> |.....................|    -4.755 |     1.794 |     4.040 |   -0.5408 |
-#> |   98|     471.32255 |     1.022 |    -1.880 |    -1.043 |   -0.7426 |
-#> |.....................|    -1.107 |    -1.512 |     1.956 |    -1.964 |
-#> |.....................|   -0.9773 |   -0.5429 |    -1.097 |    -1.122 |
-#> |.....................|   -0.6469 |   -0.5662 |   -0.9027 |   -0.4752 |
-#> |    U|     471.32255 |     93.00 |    -6.080 |    -1.008 |    -2.005 |
-#> |.....................|    -4.719 |    0.1705 |     2.005 |   0.02687 |
-#> |.....................|    0.7874 |   0.06809 |    0.5704 |    0.6787 |
-#> |.....................|     1.444 |     1.248 |    0.8385 |     1.690 |
-#> |    X|     471.32255 |     93.00 |  0.002289 |    0.2674 |    0.1347 |
-#> |.....................|  0.008922 |    0.5425 |     2.005 |   0.02687 |
-#> |.....................|    0.7874 |   0.06809 |    0.5704 |    0.6787 |
-#> |.....................|     1.444 |     1.248 |    0.8385 |     1.690 |
-#> |   99|     468.82475 |     1.022 |    -1.709 |   -0.9836 |   -0.7948 |
-#> |.....................|    -1.126 |    -1.406 |     1.521 |    -1.898 |
-#> |.....................|   -0.8984 |   -0.6279 |    -1.001 |    -1.172 |
-#> |.....................|   -0.6845 |   -0.7440 |   -0.9371 |   -0.4303 |
-#> |    U|     468.82475 |     92.98 |    -5.909 |   -0.9551 |    -2.057 |
-#> |.....................|    -4.738 |    0.2191 |     1.824 |   0.02879 |
-#> |.....................|    0.8201 |   0.06562 |    0.6400 |    0.6333 |
-#> |.....................|     1.400 |     1.078 |    0.8088 |     1.744 |
-#> |    X|     468.82475 |     92.98 |  0.002714 |    0.2779 |    0.1278 |
-#> |.....................|  0.008755 |    0.5546 |     1.824 |   0.02879 |
-#> |.....................|    0.8201 |   0.06562 |    0.6400 |    0.6333 |
-#> |.....................|     1.400 |     1.078 |    0.8088 |     1.744 |
-#> |    F| Forward Diff. |     40.86 |    0.3767 |  -0.09575 |   -0.1893 |
-#> |.....................|    -1.313 |   -0.2132 |    -3.864 |    -4.927 |
-#> |.....................|    -1.292 |    -1.079 |   -0.1017 |    -3.329 |
-#> |.....................|    -4.248 |     8.116 |     3.916 |   -0.3530 |
-#> |  100|     467.75171 |     1.017 |    -1.816 |   -0.9824 |   -0.7623 |
-#> |.....................|    -1.067 |    -1.470 |     1.678 |    -1.962 |
-#> |.....................|   -0.9501 |   -0.5667 |   -0.9995 |    -1.140 |
-#> |.....................|   -0.5909 |   -0.8204 |    -1.012 |   -0.4878 |
-#> |    U|     467.75171 |     92.51 |    -6.016 |   -0.9541 |    -2.025 |
-#> |.....................|    -4.679 |    0.1896 |     1.889 |   0.02693 |
-#> |.....................|    0.7987 |   0.06740 |    0.6413 |    0.6622 |
-#> |.....................|     1.510 |     1.005 |    0.7438 |     1.674 |
-#> |    X|     467.75171 |     92.51 |  0.002440 |    0.2781 |    0.1320 |
-#> |.....................|  0.009285 |    0.5473 |     1.889 |   0.02693 |
-#> |.....................|    0.7987 |   0.06740 |    0.6413 |    0.6622 |
-#> |.....................|     1.510 |     1.005 |    0.7438 |     1.674 |
-#> |    F| Forward Diff. |    -11.72 |    0.1617 |   -0.2966 |    0.1391 |
-#> |.....................|   -0.7722 |   -0.6625 |    -3.136 |    -6.222 |
-#> |.....................|    -1.617 |   -0.9189 |   -0.2811 |    -3.105 |
-#> |.....................|   0.05355 |     2.320 |    -3.473 |    -2.160 |
-#> |  101|     467.28745 |     1.018 |    -1.902 |   -0.9107 |   -0.7577 |
-#> |.....................|   -0.9795 |    -1.517 |     1.777 |    -1.860 |
-#> |.....................|   -0.8874 |   -0.4787 |   -0.8826 |    -1.170 |
-#> |.....................|   -0.6199 |   -0.8544 |   -0.9952 |   -0.3962 |
-#> |    U|     467.28745 |     92.66 |    -6.102 |   -0.8902 |    -2.020 |
-#> |.....................|    -4.592 |    0.1682 |     1.931 |   0.02990 |
-#> |.....................|    0.8247 |   0.06995 |    0.7268 |    0.6357 |
-#> |.....................|     1.476 |    0.9723 |    0.7587 |     1.785 |
-#> |    X|     467.28745 |     92.66 |  0.002239 |    0.2911 |    0.1327 |
-#> |.....................|   0.01013 |    0.5420 |     1.931 |   0.02990 |
-#> |.....................|    0.8247 |   0.06995 |    0.7268 |    0.6357 |
-#> |.....................|     1.476 |    0.9723 |    0.7587 |     1.785 |
-#> |    F| Forward Diff. |     21.75 |    0.1003 |     2.571 |    0.1450 |
-#> |.....................|   -0.5415 |    -1.471 |    -1.062 |    -1.774 |
-#> |.....................|     1.363 |    0.7539 |     2.182 |    -3.357 |
-#> |.....................|    -1.337 |    0.2346 |    -1.234 |   -0.8531 |
-#> |  102|     469.68385 |    0.9954 |    -1.950 |    -1.032 |   -0.7900 |
-#> |.....................|   -0.8810 |    -1.433 |     1.783 |    -1.785 |
-#> |.....................|   -0.9418 |   -0.5114 |   -0.9107 |    -1.204 |
-#> |.....................|   -0.6798 |   -0.8966 |    -1.014 |   -0.2565 |
-#> |    U|     469.68385 |     90.58 |    -6.150 |   -0.9984 |    -2.052 |
-#> |.....................|    -4.493 |    0.2066 |     1.933 |   0.03207 |
-#> |.....................|    0.8021 |   0.06900 |    0.7062 |    0.6043 |
-#> |.....................|     1.405 |    0.9320 |    0.7422 |     1.955 |
-#> |    X|     469.68385 |     90.58 |  0.002133 |    0.2693 |    0.1284 |
-#> |.....................|   0.01118 |    0.5515 |     1.933 |   0.03207 |
-#> |.....................|    0.8021 |   0.06900 |    0.7062 |    0.6043 |
-#> |.....................|     1.405 |    0.9320 |    0.7422 |     1.955 |
-#> |  103|     467.87907 |     1.005 |    -1.909 |   -0.9308 |   -0.7628 |
-#> |.....................|   -0.9639 |    -1.503 |     1.779 |    -1.847 |
-#> |.....................|   -0.8965 |   -0.4841 |   -0.8880 |    -1.173 |
-#> |.....................|   -0.6287 |   -0.8610 |   -0.9975 |   -0.3740 |
-#> |    U|     467.87907 |     91.48 |    -6.109 |   -0.9081 |    -2.025 |
-#> |.....................|    -4.576 |    0.1745 |     1.931 |   0.03026 |
-#> |.....................|    0.8209 |   0.06979 |    0.7229 |    0.6325 |
-#> |.....................|     1.466 |    0.9660 |    0.7566 |     1.812 |
-#> |    X|     467.87907 |     91.48 |  0.002222 |    0.2874 |    0.1320 |
-#> |.....................|   0.01029 |    0.5435 |     1.931 |   0.03026 |
-#> |.....................|    0.8209 |   0.06979 |    0.7229 |    0.6325 |
-#> |.....................|     1.466 |    0.9660 |    0.7566 |     1.812 |
-#> |  104|     467.53566 |     1.009 |    -1.902 |   -0.9117 |   -0.7577 |
-#> |.....................|   -0.9793 |    -1.516 |     1.778 |    -1.859 |
-#> |.....................|   -0.8880 |   -0.4790 |   -0.8835 |    -1.168 |
-#> |.....................|   -0.6194 |   -0.8545 |   -0.9947 |   -0.3959 |
-#> |    U|     467.53566 |     91.86 |    -6.102 |   -0.8912 |    -2.020 |
-#> |.....................|    -4.592 |    0.1685 |     1.931 |   0.02992 |
-#> |.....................|    0.8245 |   0.06994 |    0.7261 |    0.6369 |
-#> |.....................|     1.477 |    0.9722 |    0.7591 |     1.786 |
-#> |    X|     467.53566 |     91.86 |  0.002239 |    0.2909 |    0.1326 |
-#> |.....................|   0.01013 |    0.5420 |     1.931 |   0.02992 |
-#> |.....................|    0.8245 |   0.06994 |    0.7261 |    0.6369 |
-#> |.....................|     1.477 |    0.9722 |    0.7591 |     1.786 |
-#> |  105|     467.26444 |     1.016 |    -1.902 |   -0.9109 |   -0.7577 |
-#> |.....................|   -0.9795 |    -1.516 |     1.777 |    -1.860 |
-#> |.....................|   -0.8875 |   -0.4788 |   -0.8828 |    -1.169 |
-#> |.....................|   -0.6198 |   -0.8544 |   -0.9951 |   -0.3961 |
-#> |    U|     467.26444 |     92.48 |    -6.102 |   -0.8905 |    -2.020 |
-#> |.....................|    -4.592 |    0.1683 |     1.931 |   0.02990 |
-#> |.....................|    0.8246 |   0.06995 |    0.7266 |    0.6360 |
-#> |.....................|     1.476 |    0.9723 |    0.7588 |     1.786 |
-#> |    X|     467.26444 |     92.48 |  0.002239 |    0.2910 |    0.1326 |
-#> |.....................|   0.01013 |    0.5420 |     1.931 |   0.02990 |
-#> |.....................|    0.8246 |   0.06995 |    0.7266 |    0.6360 |
-#> |.....................|     1.476 |    0.9723 |    0.7588 |     1.786 |
-#> |    F| Forward Diff. |    -1.458 |   0.09189 |     2.450 |    0.1713 |
-#> |.....................|   -0.5320 |    -1.492 |    -1.346 |    -2.030 |
-#> |.....................|     1.374 |    0.8089 |     1.804 |    -5.854 |
-#> |.....................|    -1.303 |    0.2787 |    -1.170 |   -0.8602 |
-#> |  106|     467.25360 |     1.017 |    -1.902 |   -0.9116 |   -0.7577 |
-#> |.....................|   -0.9793 |    -1.516 |     1.778 |    -1.859 |
-#> |.....................|   -0.8879 |   -0.4790 |   -0.8833 |    -1.168 |
-#> |.....................|   -0.6195 |   -0.8545 |   -0.9948 |   -0.3959 |
-#> |    U|      467.2536 |     92.51 |    -6.102 |   -0.8910 |    -2.020 |
-#> |.....................|    -4.592 |    0.1685 |     1.931 |   0.02992 |
-#> |.....................|    0.8245 |   0.06994 |    0.7263 |    0.6374 |
-#> |.....................|     1.477 |    0.9722 |    0.7590 |     1.786 |
-#> |    X|      467.2536 |     92.51 |  0.002239 |    0.2909 |    0.1326 |
-#> |.....................|   0.01013 |    0.5420 |     1.931 |   0.02992 |
-#> |.....................|    0.8245 |   0.06994 |    0.7263 |    0.6374 |
-#> |.....................|     1.477 |    0.9722 |    0.7590 |     1.786 |
-#> |    F| Forward Diff. |     3.196 |   0.08873 |     2.446 |    0.1672 |
-#> |.....................|   -0.5342 |    -1.484 |    -1.056 |    -1.956 |
-#> |.....................|     1.373 |    0.7965 |     2.077 |    -5.722 |
-#> |.....................|    -1.292 |    0.2471 |    -1.040 |   -0.8496 |
-#> |  107|     467.24389 |     1.015 |    -1.902 |   -0.9128 |   -0.7578 |
-#> |.....................|   -0.9790 |    -1.515 |     1.778 |    -1.858 |
-#> |.....................|   -0.8886 |   -0.4794 |   -0.8844 |    -1.165 |
-#> |.....................|   -0.6188 |   -0.8546 |   -0.9942 |   -0.3955 |
-#> |    U|     467.24389 |     92.37 |    -6.102 |   -0.8922 |    -2.020 |
-#> |.....................|    -4.592 |    0.1688 |     1.931 |   0.02995 |
-#> |.....................|    0.8242 |   0.06993 |    0.7255 |    0.6400 |
-#> |.....................|     1.477 |    0.9721 |    0.7595 |     1.786 |
-#> |    X|     467.24389 |     92.37 |  0.002239 |    0.2907 |    0.1326 |
-#> |.....................|   0.01014 |    0.5421 |     1.931 |   0.02995 |
-#> |.....................|    0.8242 |   0.06993 |    0.7255 |    0.6400 |
-#> |.....................|     1.477 |    0.9721 |    0.7595 |     1.786 |
-#> |    F| Forward Diff. |    -15.43 |   0.07336 |     2.305 |    0.1893 |
-#> |.....................|   -0.5256 |    -1.495 |    -1.329 |    -2.142 |
-#> |.....................|     1.357 |    0.9382 |     1.940 |    -3.165 |
-#> |.....................|    -1.157 |    0.2760 |   -0.9277 |   -0.8566 |
-#> |  108|     467.22397 |     1.017 |    -1.902 |   -0.9138 |   -0.7581 |
-#> |.....................|   -0.9782 |    -1.514 |     1.778 |    -1.857 |
-#> |.....................|   -0.8889 |   -0.4797 |   -0.8863 |    -1.164 |
-#> |.....................|   -0.6190 |   -0.8552 |   -0.9945 |   -0.3935 |
-#> |    U|     467.22397 |     92.56 |    -6.102 |   -0.8930 |    -2.020 |
-#> |.....................|    -4.591 |    0.1692 |     1.931 |   0.02998 |
-#> |.....................|    0.8241 |   0.06992 |    0.7241 |    0.6409 |
-#> |.....................|     1.477 |    0.9715 |    0.7593 |     1.789 |
-#> |    X|     467.22397 |     92.56 |  0.002238 |    0.2905 |    0.1326 |
-#> |.....................|   0.01015 |    0.5422 |     1.931 |   0.02998 |
-#> |.....................|    0.8241 |   0.06992 |    0.7241 |    0.6409 |
-#> |.....................|     1.477 |    0.9715 |    0.7593 |     1.789 |
-#> |    F| Forward Diff. |     8.612 |   0.07601 |     2.377 |    0.1597 |
-#> |.....................|   -0.5308 |    -1.476 |    -1.038 |    -1.834 |
-#> |.....................|     1.332 |    0.7679 |     2.039 |    -3.039 |
-#> |.....................|    -1.288 |    0.2037 |    -1.093 |   -0.8313 |
-#> |  109|     467.20858 |     1.016 |    -1.903 |   -0.9153 |   -0.7584 |
-#> |.....................|   -0.9772 |    -1.513 |     1.777 |    -1.856 |
-#> |.....................|   -0.8896 |   -0.4802 |   -0.8882 |    -1.164 |
-#> |.....................|   -0.6194 |   -0.8560 |   -0.9946 |   -0.3915 |
-#> |    U|     467.20858 |     92.46 |    -6.103 |   -0.8944 |    -2.021 |
-#> |.....................|    -4.590 |    0.1698 |     1.931 |   0.03001 |
-#> |.....................|    0.8238 |   0.06990 |    0.7227 |    0.6411 |
-#> |.....................|     1.477 |    0.9707 |    0.7591 |     1.791 |
-#> |    X|     467.20858 |     92.46 |  0.002236 |    0.2902 |    0.1325 |
-#> |.....................|   0.01016 |    0.5423 |     1.931 |   0.03001 |
-#> |.....................|    0.8238 |   0.06990 |    0.7227 |    0.6411 |
-#> |.....................|     1.477 |    0.9707 |    0.7591 |     1.791 |
-#> |    F| Forward Diff. |    -3.651 |   0.07137 |     2.259 |    0.1744 |
-#> |.....................|   -0.5171 |    -1.486 |    -1.304 |    -1.934 |
-#> |.....................|     1.324 |    0.7910 |     1.690 |    -3.053 |
-#> |.....................|    -1.233 |    0.1999 |    -1.046 |   -0.8164 |
-#> |  110|     467.19548 |     1.017 |    -1.903 |   -0.9170 |   -0.7588 |
-#> |.....................|   -0.9762 |    -1.512 |     1.778 |    -1.855 |
-#> |.....................|   -0.8906 |   -0.4808 |   -0.8898 |    -1.163 |
-#> |.....................|   -0.6195 |   -0.8567 |   -0.9946 |   -0.3897 |
-#> |    U|     467.19548 |     92.56 |    -6.103 |   -0.8959 |    -2.021 |
-#> |.....................|    -4.589 |    0.1705 |     1.931 |   0.03005 |
-#> |.....................|    0.8234 |   0.06989 |    0.7215 |    0.6417 |
-#> |.....................|     1.477 |    0.9701 |    0.7592 |     1.793 |
-#> |    X|     467.19548 |     92.56 |  0.002235 |    0.2899 |    0.1325 |
-#> |.....................|   0.01017 |    0.5425 |     1.931 |   0.03005 |
-#> |.....................|    0.8234 |   0.06989 |    0.7215 |    0.6417 |
-#> |.....................|     1.477 |    0.9701 |    0.7592 |     1.793 |
-#> |    F| Forward Diff. |     9.695 |   0.07360 |     2.256 |    0.1610 |
-#> |.....................|   -0.5147 |    -1.467 |    -1.275 |    -1.734 |
-#> |.....................|     1.307 |    0.8740 |     2.039 |    -5.568 |
-#> |.....................|    -1.898 |   -0.2550 |    -1.273 |   -0.7762 |
-#> |  111|     467.17845 |     1.016 |    -1.904 |   -0.9175 |   -0.7593 |
-#> |.....................|   -0.9751 |    -1.510 |     1.777 |    -1.854 |
-#> |.....................|   -0.8907 |   -0.4813 |   -0.8918 |    -1.161 |
-#> |.....................|   -0.6194 |   -0.8571 |   -0.9949 |   -0.3876 |
-#> |    U|     467.17845 |     92.50 |    -6.104 |   -0.8963 |    -2.022 |
-#> |.....................|    -4.588 |    0.1711 |     1.930 |   0.03007 |
-#> |.....................|    0.8234 |   0.06987 |    0.7201 |    0.6433 |
-#> |.....................|     1.477 |    0.9697 |    0.7589 |     1.796 |
-#> |    X|     467.17845 |     92.50 |  0.002234 |    0.2898 |    0.1324 |
-#> |.....................|   0.01018 |    0.5427 |     1.930 |   0.03007 |
-#> |.....................|    0.8234 |   0.06987 |    0.7201 |    0.6433 |
-#> |.....................|     1.477 |    0.9697 |    0.7589 |     1.796 |
-#> |    F| Forward Diff. |     2.021 |   0.06308 |     2.194 |    0.1658 |
-#> |.....................|   -0.5050 |    -1.471 |    -1.283 |    -1.811 |
-#> |.....................|     1.304 |    0.7659 |     1.629 |    -2.860 |
-#> |.....................|    -1.234 |    0.1434 |    -1.025 |   -0.7796 |
-#> |  112|     467.16518 |     1.015 |    -1.904 |   -0.9192 |   -0.7596 |
-#> |.....................|   -0.9742 |    -1.509 |     1.777 |    -1.853 |
-#> |.....................|   -0.8917 |   -0.4819 |   -0.8931 |    -1.160 |
-#> |.....................|   -0.6190 |   -0.8574 |   -0.9946 |   -0.3864 |
-#> |    U|     467.16518 |     92.39 |    -6.104 |   -0.8978 |    -2.022 |
-#> |.....................|    -4.587 |    0.1719 |     1.931 |   0.03011 |
-#> |.....................|    0.8229 |   0.06985 |    0.7191 |    0.6447 |
-#> |.....................|     1.477 |    0.9694 |    0.7592 |     1.797 |
-#> |    X|     467.16518 |     92.39 |  0.002234 |    0.2895 |    0.1324 |
-#> |.....................|   0.01019 |    0.5429 |     1.931 |   0.03011 |
-#> |.....................|    0.8229 |   0.06985 |    0.7191 |    0.6447 |
-#> |.....................|     1.477 |    0.9694 |    0.7592 |     1.797 |
-#> |    F| Forward Diff. |    -11.15 |   0.05292 |     2.063 |    0.1800 |
-#> |.....................|   -0.4962 |    -1.473 |   -0.9311 |    -1.912 |
-#> |.....................|     1.287 |    0.8965 |     1.659 |    -5.399 |
-#> |.....................|    -1.766 |   -0.2649 |    -1.228 |   -0.7899 |
-#> |  113|     467.14275 |     1.016 |    -1.904 |   -0.9201 |   -0.7599 |
-#> |.....................|   -0.9736 |    -1.507 |     1.777 |    -1.851 |
-#> |.....................|   -0.8922 |   -0.4826 |   -0.8948 |    -1.157 |
-#> |.....................|   -0.6182 |   -0.8576 |   -0.9943 |   -0.3850 |
-#> |    U|     467.14275 |     92.43 |    -6.104 |   -0.8986 |    -2.022 |
-#> |.....................|    -4.586 |    0.1725 |     1.931 |   0.03014 |
-#> |.....................|    0.8227 |   0.06984 |    0.7179 |    0.6470 |
-#> |.....................|     1.478 |    0.9693 |    0.7594 |     1.799 |
-#> |    X|     467.14275 |     92.43 |  0.002233 |    0.2893 |    0.1324 |
-#> |.....................|   0.01019 |    0.5430 |     1.931 |   0.03014 |
-#> |.....................|    0.8227 |   0.06984 |    0.7179 |    0.6470 |
-#> |.....................|     1.478 |    0.9693 |    0.7594 |     1.799 |
-#> |    F| Forward Diff. |    -6.177 |   0.04590 |     2.051 |    0.1758 |
-#> |.....................|   -0.4936 |    -1.461 |   -0.9893 |    -1.828 |
-#> |.....................|     1.266 |    0.7615 |     1.545 |    -5.206 |
-#> |.....................|    -1.792 |   -0.2512 |    -1.220 |   -0.7551 |
-#> |  114|     467.10820 |     1.017 |    -1.905 |   -0.9220 |   -0.7605 |
-#> |.....................|   -0.9724 |    -1.505 |     1.777 |    -1.849 |
-#> |.....................|   -0.8932 |   -0.4835 |   -0.8976 |    -1.151 |
-#> |.....................|   -0.6164 |   -0.8576 |   -0.9935 |   -0.3828 |
-#> |    U|      467.1082 |     92.55 |    -6.105 |   -0.9003 |    -2.023 |
-#> |.....................|    -4.585 |    0.1737 |     1.930 |   0.03020 |
-#> |.....................|    0.8223 |   0.06981 |    0.7158 |    0.6522 |
-#> |.....................|     1.480 |    0.9692 |    0.7601 |     1.802 |
-#> |    X|      467.1082 |     92.55 |  0.002232 |    0.2890 |    0.1323 |
-#> |.....................|   0.01020 |    0.5433 |     1.930 |   0.03020 |
-#> |.....................|    0.8223 |   0.06981 |    0.7158 |    0.6522 |
-#> |.....................|     1.480 |    0.9692 |    0.7601 |     1.802 |
-#> |    F| Forward Diff. |     8.449 |   0.03092 |     2.044 |    0.1611 |
-#> |.....................|   -0.4934 |    -1.430 |    -1.221 |    -1.596 |
-#> |.....................|     1.229 |    0.8691 |     1.875 |    -2.123 |
-#> |.....................|    -1.605 |   -0.2558 |    -1.009 |   -0.7122 |
-#> |  115|     467.10106 |     1.014 |    -1.905 |   -0.9236 |   -0.7611 |
-#> |.....................|   -0.9712 |    -1.502 |     1.777 |    -1.847 |
-#> |.....................|   -0.8940 |   -0.4849 |   -0.9012 |    -1.147 |
-#> |.....................|   -0.6148 |   -0.8578 |   -0.9928 |   -0.3803 |
-#> |    U|     467.10106 |     92.28 |    -6.105 |   -0.9017 |    -2.023 |
-#> |.....................|    -4.584 |    0.1749 |     1.930 |   0.03026 |
-#> |.....................|    0.8220 |   0.06977 |    0.7132 |    0.6562 |
-#> |.....................|     1.482 |    0.9690 |    0.7607 |     1.805 |
-#> |    X|     467.10106 |     92.28 |  0.002232 |    0.2887 |    0.1322 |
-#> |.....................|   0.01022 |    0.5436 |     1.930 |   0.03026 |
-#> |.....................|    0.8220 |   0.06977 |    0.7132 |    0.6562 |
-#> |.....................|     1.482 |    0.9690 |    0.7607 |     1.805 |
-#> |    F| Forward Diff. |    -24.17 |  0.001665 |     1.814 |    0.1960 |
-#> |.....................|   -0.4738 |    -1.444 |   -0.8955 |    -1.908 |
-#> |.....................|     1.221 |    0.7910 |     1.755 |    -3.560 |
-#> |.....................|    -2.244 |   -0.2675 |   -0.8607 |   -0.7175 |
-#> |  116|     467.04630 |     1.016 |    -1.905 |   -0.9246 |   -0.7619 |
-#> |.....................|   -0.9696 |    -1.499 |     1.777 |    -1.845 |
-#> |.....................|   -0.8944 |   -0.4866 |   -0.9055 |    -1.143 |
-#> |.....................|   -0.6133 |   -0.8582 |   -0.9923 |   -0.3775 |
-#> |    U|      467.0463 |     92.45 |    -6.105 |   -0.9026 |    -2.024 |
-#> |.....................|    -4.582 |    0.1762 |     1.930 |   0.03032 |
-#> |.....................|    0.8218 |   0.06972 |    0.7101 |    0.6601 |
-#> |.....................|     1.484 |    0.9686 |    0.7611 |     1.808 |
-#> |    X|      467.0463 |     92.45 |  0.002231 |    0.2885 |    0.1321 |
-#> |.....................|   0.01023 |    0.5439 |     1.930 |   0.03032 |
-#> |.....................|    0.8218 |   0.06972 |    0.7101 |    0.6601 |
-#> |.....................|     1.484 |    0.9686 |    0.7611 |     1.808 |
-#> |    F| Forward Diff. |    -2.647 | -0.007887 |     1.876 |    0.1719 |
-#> |.....................|   -0.4730 |    -1.410 |   -0.8701 |    -1.589 |
-#> |.....................|     1.184 |    0.7244 |     1.544 |    -4.110 |
-#> |.....................|    -1.544 |   -0.3120 |   -0.9430 |   -0.6527 |
-#> |  117|     467.02543 |     1.017 |    -1.906 |   -0.9263 |   -0.7625 |
-#> |.....................|   -0.9684 |    -1.497 |     1.777 |    -1.843 |
-#> |.....................|   -0.8954 |   -0.4879 |   -0.9089 |    -1.137 |
-#> |.....................|   -0.6116 |   -0.8583 |   -0.9915 |   -0.3753 |
-#> |    U|     467.02543 |     92.58 |    -6.106 |   -0.9041 |    -2.025 |
-#> |.....................|    -4.581 |    0.1775 |     1.930 |   0.03038 |
-#> |.....................|    0.8214 |   0.06968 |    0.7076 |    0.6649 |
-#> |.....................|     1.486 |    0.9686 |    0.7618 |     1.811 |
-#> |    X|     467.02543 |     92.58 |  0.002230 |    0.2882 |    0.1320 |
-#> |.....................|   0.01025 |    0.5443 |     1.930 |   0.03038 |
-#> |.....................|    0.8214 |   0.06968 |    0.7076 |    0.6649 |
-#> |.....................|     1.486 |    0.9686 |    0.7618 |     1.811 |
-#> |    F| Forward Diff. |     12.94 |  -0.02385 |     1.879 |    0.1542 |
-#> |.....................|   -0.4735 |    -1.378 |   -0.8918 |    -1.355 |
-#> |.....................|     1.131 |    0.6590 |     1.631 |    -3.618 |
-#> |.....................|    -1.430 |   -0.2321 |   -0.8462 |   -0.6495 |
-#> |  118|     466.99646 |     1.016 |    -1.906 |   -0.9273 |   -0.7632 |
-#> |.....................|   -0.9670 |    -1.494 |     1.776 |    -1.841 |
-#> |.....................|   -0.8958 |   -0.4892 |   -0.9132 |    -1.133 |
-#> |.....................|   -0.6101 |   -0.8587 |   -0.9911 |   -0.3725 |
-#> |    U|     466.99646 |     92.42 |    -6.106 |   -0.9050 |    -2.026 |
-#> |.....................|    -4.579 |    0.1788 |     1.930 |   0.03043 |
-#> |.....................|    0.8212 |   0.06964 |    0.7044 |    0.6690 |
-#> |.....................|     1.488 |    0.9682 |    0.7622 |     1.814 |
-#> |    X|     466.99646 |     92.42 |  0.002230 |    0.2880 |    0.1319 |
-#> |.....................|   0.01026 |    0.5446 |     1.930 |   0.03043 |
-#> |.....................|    0.8212 |   0.06964 |    0.7044 |    0.6690 |
-#> |.....................|     1.488 |    0.9682 |    0.7622 |     1.814 |
-#> |    F| Forward Diff. |    -5.590 |  -0.05004 |     1.738 |    0.1737 |
-#> |.....................|   -0.4573 |    -1.378 |   -0.8791 |    -1.534 |
-#> |.....................|     1.117 |    0.8064 |     1.528 |    -3.141 |
-#> |.....................|   -0.8220 |    0.1296 |   -0.3838 |   -0.6246 |
-#> |  119|     466.97639 |     1.017 |    -1.906 |   -0.9282 |   -0.7640 |
-#> |.....................|   -0.9655 |    -1.490 |     1.776 |    -1.839 |
-#> |.....................|   -0.8964 |   -0.4910 |   -0.9175 |    -1.129 |
-#> |.....................|   -0.6092 |   -0.8593 |   -0.9910 |   -0.3693 |
-#> |    U|     466.97639 |     92.52 |    -6.106 |   -0.9059 |    -2.026 |
-#> |.....................|    -4.578 |    0.1803 |     1.930 |   0.03049 |
-#> |.....................|    0.8210 |   0.06959 |    0.7013 |    0.6726 |
-#> |.....................|     1.489 |    0.9676 |    0.7623 |     1.818 |
-#> |    X|     466.97639 |     92.52 |  0.002230 |    0.2878 |    0.1318 |
-#> |.....................|   0.01028 |    0.5450 |     1.930 |   0.03049 |
-#> |.....................|    0.8210 |   0.06959 |    0.7013 |    0.6726 |
-#> |.....................|     1.489 |    0.9676 |    0.7623 |     1.818 |
-#> |    F| Forward Diff. |     7.027 |  -0.06281 |     1.755 |    0.1604 |
-#> |.....................|   -0.4507 |    -1.349 |   -0.8053 |    -1.299 |
-#> |.....................|     1.095 |    0.6623 |     1.032 |    -2.794 |
-#> |.....................|   -0.8171 |   0.07286 |   -0.3538 |   -0.5889 |
-#> |  120|     466.96001 |     1.015 |    -1.906 |   -0.9299 |   -0.7649 |
-#> |.....................|   -0.9637 |    -1.486 |     1.775 |    -1.837 |
-#> |.....................|   -0.8976 |   -0.4931 |   -0.9192 |    -1.125 |
-#> |.....................|   -0.6091 |   -0.8600 |   -0.9916 |   -0.3657 |
-#> |    U|     466.96001 |     92.40 |    -6.106 |   -0.9074 |    -2.027 |
-#> |.....................|    -4.576 |    0.1824 |     1.930 |   0.03055 |
-#> |.....................|    0.8205 |   0.06953 |    0.7000 |    0.6758 |
-#> |.....................|     1.489 |    0.9669 |    0.7618 |     1.823 |
-#> |    X|     466.96001 |     92.40 |  0.002230 |    0.2875 |    0.1317 |
-#> |.....................|   0.01029 |    0.5455 |     1.930 |   0.03055 |
-#> |.....................|    0.8205 |   0.06953 |    0.7000 |    0.6758 |
-#> |.....................|     1.489 |    0.9669 |    0.7618 |     1.823 |
-#> |    F| Forward Diff. |    -7.315 |  -0.08361 |     1.595 |    0.1755 |
-#> |.....................|   -0.4289 |    -1.331 |   -0.8104 |    -1.428 |
-#> |.....................|     1.055 |    0.7710 |     1.242 |    -2.826 |
-#> |.....................|    -1.346 |   -0.3282 |   -0.6399 |   -0.5709 |
-#> |  121|     466.94053 |     1.016 |    -1.905 |   -0.9315 |   -0.7662 |
-#> |.....................|   -0.9617 |    -1.480 |     1.774 |    -1.835 |
-#> |.....................|   -0.8987 |   -0.4954 |   -0.9193 |    -1.121 |
-#> |.....................|   -0.6079 |   -0.8601 |   -0.9919 |   -0.3632 |
-#> |    U|     466.94053 |     92.48 |    -6.105 |   -0.9088 |    -2.029 |
-#> |.....................|    -4.574 |    0.1849 |     1.929 |   0.03061 |
-#> |.....................|    0.8200 |   0.06946 |    0.6999 |    0.6792 |
-#> |.....................|     1.490 |    0.9668 |    0.7615 |     1.826 |
-#> |    X|     466.94053 |     92.48 |  0.002231 |    0.2873 |    0.1315 |
-#> |.....................|   0.01031 |    0.5461 |     1.929 |   0.03061 |
-#> |.....................|    0.8200 |   0.06946 |    0.6999 |    0.6792 |
-#> |.....................|     1.490 |    0.9668 |    0.7615 |     1.826 |
-#> |    F| Forward Diff. |     2.448 |  -0.09452 |     1.578 |    0.1631 |
-#> |.....................|   -0.4178 |    -1.275 |   -0.7880 |    -1.291 |
-#> |.....................|     1.013 |    0.7275 |     1.336 |   -0.1176 |
-#> |.....................|    -1.297 |   -0.2757 |   -0.6338 |   -0.5586 |
-#> |  122|     466.92529 |     1.015 |    -1.905 |   -0.9321 |   -0.7676 |
-#> |.....................|   -0.9593 |    -1.476 |     1.775 |    -1.833 |
-#> |.....................|   -0.8992 |   -0.4984 |   -0.9232 |    -1.122 |
-#> |.....................|   -0.6063 |   -0.8604 |   -0.9916 |   -0.3612 |
-#> |    U|     466.92529 |     92.34 |    -6.105 |   -0.9093 |    -2.030 |
-#> |.....................|    -4.572 |    0.1871 |     1.930 |   0.03066 |
-#> |.....................|    0.8198 |   0.06938 |    0.6971 |    0.6791 |
-#> |.....................|     1.492 |    0.9666 |    0.7618 |     1.828 |
-#> |    X|     466.92529 |     92.34 |  0.002233 |    0.2871 |    0.1313 |
-#> |.....................|   0.01034 |    0.5466 |     1.930 |   0.03066 |
-#> |.....................|    0.8198 |   0.06938 |    0.6971 |    0.6791 |
-#> |.....................|     1.492 |    0.9666 |    0.7618 |     1.828 |
-#> |    F| Forward Diff. |    -12.72 |  -0.09950 |     1.479 |    0.1754 |
-#> |.....................|   -0.4012 |    -1.242 |   -0.7866 |    -1.413 |
-#> |.....................|    0.9668 |    0.6187 |    0.9349 |    -2.630 |
-#> |.....................|    -1.260 |   -0.3489 |   -0.4063 |   -0.5476 |
-#> |  123|     466.89942 |     1.016 |    -1.904 |   -0.9326 |   -0.7693 |
-#> |.....................|   -0.9564 |    -1.470 |     1.775 |    -1.832 |
-#> |.....................|   -0.8995 |   -0.5006 |   -0.9260 |    -1.122 |
-#> |.....................|   -0.6055 |   -0.8609 |   -0.9921 |   -0.3587 |
-#> |    U|     466.89942 |     92.48 |    -6.104 |   -0.9097 |    -2.032 |
-#> |.....................|    -4.569 |    0.1897 |     1.929 |   0.03069 |
-#> |.....................|    0.8197 |   0.06931 |    0.6950 |    0.6788 |
-#> |.....................|     1.493 |    0.9661 |    0.7614 |     1.831 |
-#> |    X|     466.89942 |     92.48 |  0.002235 |    0.2871 |    0.1311 |
-#> |.....................|   0.01037 |    0.5473 |     1.929 |   0.03069 |
-#> |.....................|    0.8197 |   0.06931 |    0.6950 |    0.6788 |
-#> |.....................|     1.493 |    0.9661 |    0.7614 |     1.831 |
-#> |    F| Forward Diff. |     3.439 |  -0.09008 |     1.544 |    0.1555 |
-#> |.....................|   -0.3845 |    -1.174 |   -0.7709 |    -1.201 |
-#> |.....................|    0.9305 |    0.6799 |     1.153 |    -2.871 |
-#> |.....................|    -1.766 |   -0.2963 |   -0.5389 |   -0.5305 |
-#> |  124|     466.87885 |     1.016 |    -1.902 |   -0.9335 |   -0.7713 |
-#> |.....................|   -0.9544 |    -1.465 |     1.775 |    -1.831 |
-#> |.....................|   -0.8988 |   -0.5028 |   -0.9291 |    -1.120 |
-#> |.....................|   -0.6025 |   -0.8609 |   -0.9918 |   -0.3573 |
-#> |    U|     466.87885 |     92.42 |    -6.102 |   -0.9106 |    -2.034 |
-#> |.....................|    -4.567 |    0.1922 |     1.930 |   0.03072 |
-#> |.....................|    0.8200 |   0.06925 |    0.6928 |    0.6803 |
-#> |.....................|     1.497 |    0.9661 |    0.7616 |     1.833 |
-#> |    X|     466.87885 |     92.42 |  0.002239 |    0.2869 |    0.1309 |
-#> |.....................|   0.01039 |    0.5479 |     1.930 |   0.03072 |
-#> |.....................|    0.8200 |   0.06925 |    0.6928 |    0.6803 |
-#> |.....................|     1.497 |    0.9661 |    0.7616 |     1.833 |
-#> |    F| Forward Diff. |    -3.274 |  -0.09794 |     1.477 |    0.1445 |
-#> |.....................|   -0.3711 |    -1.126 |   -0.7697 |    -1.253 |
-#> |.....................|    0.9213 |    0.5797 |    0.6929 |    -2.254 |
-#> |.....................|   -0.4364 |   0.05549 |  -0.07007 |   -0.5105 |
-#> |  125|     466.87374 |     1.017 |    -1.901 |   -0.9363 |   -0.7725 |
-#> |.....................|   -0.9523 |    -1.459 |     1.775 |    -1.829 |
-#> |.....................|   -0.9004 |   -0.5050 |   -0.9284 |    -1.119 |
-#> |.....................|   -0.6029 |   -0.8616 |   -0.9930 |   -0.3542 |
-#> |    U|     466.87374 |     92.57 |    -6.101 |   -0.9131 |    -2.035 |
-#> |.....................|    -4.565 |    0.1945 |     1.929 |   0.03078 |
-#> |.....................|    0.8193 |   0.06919 |    0.6933 |    0.6817 |
-#> |.....................|     1.496 |    0.9655 |    0.7605 |     1.836 |
-#> |    X|     466.87374 |     92.57 |  0.002241 |    0.2864 |    0.1307 |
-#> |.....................|   0.01041 |    0.5485 |     1.929 |   0.03078 |
-#> |.....................|    0.8193 |   0.06919 |    0.6933 |    0.6817 |
-#> |.....................|     1.496 |    0.9655 |    0.7605 |     1.836 |
-#> |    F| Forward Diff. |     13.60 |  -0.09484 |     1.445 |    0.1251 |
-#> |.....................|   -0.3584 |    -1.070 |   -0.7354 |    -1.048 |
-#> |.....................|    0.8551 |    0.6144 |    0.8824 | -0.009520 |
-#> |.....................|   -0.4410 |   0.04024 |   -0.2274 |   -0.5153 |
-#> |  126|     466.85547 |     1.016 |    -1.900 |   -0.9388 |   -0.7737 |
-#> |.....................|   -0.9500 |    -1.454 |     1.774 |    -1.828 |
-#> |.....................|   -0.9020 |   -0.5070 |   -0.9271 |    -1.119 |
-#> |.....................|   -0.6040 |   -0.8622 |   -0.9946 |   -0.3509 |
-#> |    U|     466.85547 |     92.42 |    -6.100 |   -0.9152 |    -2.036 |
-#> |.....................|    -4.562 |    0.1970 |     1.929 |   0.03083 |
-#> |.....................|    0.8186 |   0.06913 |    0.6942 |    0.6818 |
-#> |.....................|     1.495 |    0.9648 |    0.7592 |     1.841 |
-#> |    X|     466.85547 |     92.42 |  0.002243 |    0.2859 |    0.1305 |
-#> |.....................|   0.01044 |    0.5491 |     1.929 |   0.03083 |
-#> |.....................|    0.8186 |   0.06913 |    0.6942 |    0.6818 |
-#> |.....................|     1.495 |    0.9648 |    0.7592 |     1.841 |
-#> |    F| Forward Diff. |    -2.539 |  -0.09755 |     1.262 |    0.1433 |
-#> |.....................|   -0.3291 |    -1.038 |   -0.7482 |    -1.225 |
-#> |.....................|    0.8087 |    0.5023 |    0.8171 | -0.005344 |
-#> |.....................|   -0.4685 |   0.01356 |   -0.1499 |   -0.5112 |
-#> |  127|     466.84409 |     1.016 |    -1.899 |   -0.9408 |   -0.7751 |
-#> |.....................|   -0.9477 |    -1.449 |     1.774 |    -1.826 |
-#> |.....................|   -0.9037 |   -0.5088 |   -0.9269 |    -1.119 |
-#> |.....................|   -0.6048 |   -0.8630 |   -0.9960 |   -0.3473 |
-#> |    U|     466.84409 |     92.47 |    -6.099 |   -0.9171 |    -2.037 |
-#> |.....................|    -4.560 |    0.1996 |     1.929 |   0.03088 |
-#> |.....................|    0.8179 |   0.06907 |    0.6944 |    0.6816 |
-#> |.....................|     1.494 |    0.9641 |    0.7580 |     1.845 |
-#> |    X|     466.84409 |     92.47 |  0.002245 |    0.2856 |    0.1304 |
-#> |.....................|   0.01046 |    0.5497 |     1.929 |   0.03088 |
-#> |.....................|    0.8179 |   0.06907 |    0.6944 |    0.6816 |
-#> |.....................|     1.494 |    0.9641 |    0.7580 |     1.845 |
-#> |    F| Forward Diff. |     3.205 |  -0.09489 |     1.201 |    0.1289 |
-#> |.....................|   -0.3142 |   -0.9889 |   -0.7667 |    -1.156 |
-#> |.....................|    0.7401 |    0.5570 |     1.301 |    -1.479 |
-#> |.....................|    -1.860 |   -0.4540 |   -0.5722 |   -0.5005 |
-#> |  128|     466.83069 |     1.016 |    -1.897 |   -0.9405 |   -0.7762 |
-#> |.....................|   -0.9462 |    -1.443 |     1.775 |    -1.825 |
-#> |.....................|   -0.9047 |   -0.5101 |   -0.9307 |    -1.119 |
-#> |.....................|   -0.6046 |   -0.8636 |   -0.9969 |   -0.3435 |
-#> |    U|     466.83069 |     92.41 |    -6.097 |   -0.9168 |    -2.039 |
-#> |.....................|    -4.559 |    0.2019 |     1.929 |   0.03091 |
-#> |.....................|    0.8175 |   0.06904 |    0.6917 |    0.6819 |
-#> |.....................|     1.494 |    0.9635 |    0.7572 |     1.850 |
-#> |    X|     466.83069 |     92.41 |  0.002250 |    0.2856 |    0.1302 |
-#> |.....................|   0.01048 |    0.5503 |     1.929 |   0.03091 |
-#> |.....................|    0.8175 |   0.06904 |    0.6917 |    0.6819 |
-#> |.....................|     1.494 |    0.9635 |    0.7572 |     1.850 |
-#> |  129|     466.81923 |     1.016 |    -1.894 |   -0.9398 |   -0.7773 |
-#> |.....................|   -0.9447 |    -1.438 |     1.775 |    -1.824 |
-#> |.....................|   -0.9056 |   -0.5113 |   -0.9343 |    -1.119 |
-#> |.....................|   -0.6049 |   -0.8643 |   -0.9979 |   -0.3395 |
-#> |    U|     466.81923 |     92.43 |    -6.094 |   -0.9162 |    -2.040 |
-#> |.....................|    -4.557 |    0.2043 |     1.930 |   0.03094 |
-#> |.....................|    0.8171 |   0.06900 |    0.6890 |    0.6818 |
-#> |.....................|     1.494 |    0.9628 |    0.7563 |     1.854 |
-#> |    X|     466.81923 |     92.43 |  0.002255 |    0.2857 |    0.1301 |
-#> |.....................|   0.01049 |    0.5509 |     1.930 |   0.03094 |
-#> |.....................|    0.8171 |   0.06900 |    0.6890 |    0.6818 |
-#> |.....................|     1.494 |    0.9628 |    0.7563 |     1.854 |
-#> |  130|     466.78977 |     1.016 |    -1.887 |   -0.9376 |   -0.7810 |
-#> |.....................|   -0.9400 |    -1.422 |     1.776 |    -1.820 |
-#> |.....................|   -0.9086 |   -0.5153 |   -0.9461 |    -1.119 |
-#> |.....................|   -0.6057 |   -0.8666 |    -1.001 |   -0.3266 |
-#> |    U|     466.78977 |     92.47 |    -6.087 |   -0.9142 |    -2.043 |
-#> |.....................|    -4.552 |    0.2120 |     1.930 |   0.03105 |
-#> |.....................|    0.8159 |   0.06889 |    0.6804 |    0.6815 |
-#> |.....................|     1.493 |    0.9606 |    0.7533 |     1.870 |
-#> |    X|     466.78977 |     92.47 |  0.002272 |    0.2861 |    0.1296 |
-#> |.....................|   0.01054 |    0.5528 |     1.930 |   0.03105 |
-#> |.....................|    0.8159 |   0.06889 |    0.6804 |    0.6815 |
-#> |.....................|     1.493 |    0.9606 |    0.7533 |     1.870 |
-#> |  131|     466.76586 |     1.017 |    -1.875 |   -0.9340 |   -0.7871 |
-#> |.....................|   -0.9321 |    -1.394 |     1.779 |    -1.814 |
-#> |.....................|   -0.9134 |   -0.5218 |   -0.9656 |    -1.119 |
-#> |.....................|   -0.6071 |   -0.8705 |    -1.007 |   -0.3052 |
-#> |    U|     466.76586 |     92.53 |    -6.075 |   -0.9110 |    -2.049 |
-#> |.....................|    -4.545 |    0.2247 |     1.931 |   0.03121 |
-#> |.....................|    0.8139 |   0.06870 |    0.6661 |    0.6811 |
-#> |.....................|     1.491 |    0.9569 |    0.7485 |     1.896 |
-#> |    X|     466.76586 |     92.53 |  0.002300 |    0.2868 |    0.1288 |
-#> |.....................|   0.01062 |    0.5559 |     1.931 |   0.03121 |
-#> |.....................|    0.8139 |   0.06870 |    0.6661 |    0.6811 |
-#> |.....................|     1.491 |    0.9569 |    0.7485 |     1.896 |
-#> |    F| Forward Diff. |     10.71 |  -0.05605 |     1.440 |   0.09508 |
-#> |.....................|   -0.1459 |   -0.5070 |   -0.9907 |   -0.8007 |
-#> |.....................|    0.4069 |    0.2923 |   0.01818 |    -1.553 |
-#> |.....................|    -1.109 |   -0.3306 |   -0.3991 |   -0.2309 |
-#> |  132|     466.72646 |     1.014 |    -1.848 |   -0.9815 |   -0.8092 |
-#> |.....................|   -0.9160 |    -1.342 |     1.783 |    -1.808 |
-#> |.....................|   -0.9032 |   -0.5322 |   -0.9570 |    -1.117 |
-#> |.....................|   -0.6032 |   -0.8748 |    -1.022 |   -0.2748 |
-#> |    U|     466.72646 |     92.30 |    -6.048 |   -0.9533 |    -2.072 |
-#> |.....................|    -4.528 |    0.2483 |     1.933 |   0.03140 |
-#> |.....................|    0.8182 |   0.06840 |    0.6724 |    0.6828 |
-#> |.....................|     1.496 |    0.9528 |    0.7357 |     1.933 |
-#> |    X|     466.72646 |     92.30 |  0.002362 |    0.2782 |    0.1260 |
-#> |.....................|   0.01080 |    0.5618 |     1.933 |   0.03140 |
-#> |.....................|    0.8182 |   0.06840 |    0.6724 |    0.6828 |
-#> |.....................|     1.496 |    0.9528 |    0.7357 |     1.933 |
-#> |    F| Forward Diff. |    -13.11 |  -0.01237 |   -0.5306 |  0.001870 |
-#> |.....................|   0.01074 | -0.001553 |   -0.5011 |    -1.124 |
-#> |.....................|    0.5240 |    0.3999 |    0.1337 |    0.6209 |
-#> |.....................|   -0.3667 |   -0.5464 |   -0.9326 |   -0.1861 |
-#> |  133|     466.72714 |     1.014 |    -1.830 |   -0.9704 |   -0.8250 |
-#> |.....................|   -0.9153 |    -1.342 |     1.791 |    -1.785 |
-#> |.....................|   -0.9449 |   -0.5943 |   -0.9266 |    -1.116 |
-#> |.....................|   -0.5962 |   -0.8737 |    -1.020 |   -0.2698 |
-#> |    U|     466.72714 |     92.32 |    -6.030 |   -0.9434 |    -2.087 |
-#> |.....................|    -4.528 |    0.2486 |     1.936 |   0.03205 |
-#> |.....................|    0.8009 |   0.06660 |    0.6946 |    0.6846 |
-#> |.....................|     1.504 |    0.9539 |    0.7372 |     1.939 |
-#> |    X|     466.72714 |     92.32 |  0.002405 |    0.2802 |    0.1240 |
-#> |.....................|   0.01081 |    0.5618 |     1.936 |   0.03205 |
-#> |.....................|    0.8009 |   0.06660 |    0.6946 |    0.6846 |
-#> |.....................|     1.504 |    0.9539 |    0.7372 |     1.939 |
-#> |  134|     466.69721 |     1.015 |    -1.839 |   -0.9760 |   -0.8170 |
-#> |.....................|   -0.9156 |    -1.342 |     1.787 |    -1.797 |
-#> |.....................|   -0.9238 |   -0.5630 |   -0.9420 |    -1.117 |
-#> |.....................|   -0.5997 |   -0.8742 |    -1.021 |   -0.2723 |
-#> |    U|     466.69721 |     92.41 |    -6.039 |   -0.9484 |    -2.079 |
-#> |.....................|    -4.528 |    0.2485 |     1.935 |   0.03173 |
-#> |.....................|    0.8096 |   0.06750 |    0.6834 |    0.6836 |
-#> |.....................|     1.500 |    0.9534 |    0.7365 |     1.936 |
-#> |    X|     466.69721 |     92.41 |  0.002383 |    0.2792 |    0.1250 |
-#> |.....................|   0.01080 |    0.5618 |     1.935 |   0.03173 |
-#> |.....................|    0.8096 |   0.06750 |    0.6834 |    0.6836 |
-#> |.....................|     1.500 |    0.9534 |    0.7365 |     1.936 |
-#> |    F| Forward Diff. |    0.5723 |  0.006769 |   -0.2879 |  -0.06332 |
-#> |.....................|   0.01114 |  -0.03155 |   -0.3915 |   -0.7923 |
-#> |.....................|   -0.3201 |   -0.2330 |    0.8086 |    -1.424 |
-#> |.....................|   -0.3663 |   -0.4815 |   -0.7933 |   -0.2384 |
-#> |  135|     466.73286 |     1.017 |    -1.834 |   -0.9731 |   -0.8131 |
-#> |.....................|   -0.9227 |    -1.351 |     1.796 |    -1.779 |
-#> |.....................|   -0.9201 |   -0.5595 |   -0.9572 |    -1.109 |
-#> |.....................|   -0.6142 |   -0.8686 |    -1.016 |   -0.2440 |
-#> |    U|     466.73286 |     92.54 |    -6.034 |   -0.9458 |    -2.075 |
-#> |.....................|    -4.535 |    0.2444 |     1.938 |   0.03223 |
-#> |.....................|    0.8111 |   0.06760 |    0.6723 |    0.6901 |
-#> |.....................|     1.483 |    0.9587 |    0.7409 |     1.970 |
-#> |    X|     466.73286 |     92.54 |  0.002396 |    0.2797 |    0.1255 |
-#> |.....................|   0.01072 |    0.5608 |     1.938 |   0.03223 |
-#> |.....................|    0.8111 |   0.06760 |    0.6723 |    0.6901 |
-#> |.....................|     1.483 |    0.9587 |    0.7409 |     1.970 |
-#> |  136|     466.69733 |     1.015 |    -1.838 |   -0.9750 |   -0.8159 |
-#> |.....................|   -0.9176 |    -1.345 |     1.790 |    -1.791 |
-#> |.....................|   -0.9226 |   -0.5619 |   -0.9467 |    -1.114 |
-#> |.....................|   -0.6033 |   -0.8723 |    -1.019 |   -0.2644 |
-#> |    U|     466.69733 |     92.40 |    -6.038 |   -0.9475 |    -2.078 |
-#> |.....................|    -4.530 |    0.2474 |     1.936 |   0.03188 |
-#> |.....................|    0.8101 |   0.06754 |    0.6799 |    0.6863 |
-#> |.....................|     1.496 |    0.9552 |    0.7382 |     1.945 |
-#> |    X|     466.69733 |     92.40 |  0.002386 |    0.2794 |    0.1251 |
-#> |.....................|   0.01078 |    0.5615 |     1.936 |   0.03188 |
-#> |.....................|    0.8101 |   0.06754 |    0.6799 |    0.6863 |
-#> |.....................|     1.496 |    0.9552 |    0.7382 |     1.945 |
-#> |  137|     466.69584 |     1.015 |    -1.839 |   -0.9754 |   -0.8165 |
-#> |.....................|   -0.9164 |    -1.343 |     1.788 |    -1.794 |
-#> |.....................|   -0.9231 |   -0.5623 |   -0.9445 |    -1.114 |
-#> |.....................|   -0.6009 |   -0.8731 |    -1.020 |   -0.2689 |
-#> |    U|     466.69584 |     92.37 |    -6.039 |   -0.9478 |    -2.079 |
-#> |.....................|    -4.529 |    0.2480 |     1.935 |   0.03180 |
-#> |.....................|    0.8099 |   0.06752 |    0.6815 |    0.6857 |
-#> |.....................|     1.499 |    0.9544 |    0.7377 |     1.940 |
-#> |    X|     466.69584 |     92.37 |  0.002384 |    0.2793 |    0.1251 |
-#> |.....................|   0.01079 |    0.5617 |     1.935 |   0.03180 |
-#> |.....................|    0.8099 |   0.06752 |    0.6815 |    0.6857 |
-#> |.....................|     1.499 |    0.9544 |    0.7377 |     1.940 |
-#> |    F| Forward Diff. |    -3.069 | -0.001275 |   -0.2861 |  -0.04975 |
-#> |.....................|   0.01387 |  -0.05203 |   -0.3437 |   -0.7173 |
-#> |.....................|   -0.2694 |   -0.1778 |    0.5026 |    0.8511 |
-#> |.....................|   -0.9213 |   -0.7376 |   -0.9765 |   -0.1682 |
-#> |  138|     466.68962 |     1.016 |    -1.839 |   -0.9764 |   -0.8159 |
-#> |.....................|   -0.9167 |    -1.342 |     1.790 |    -1.793 |
-#> |.....................|   -0.9191 |   -0.5597 |   -0.9461 |    -1.115 |
-#> |.....................|   -0.6002 |   -0.8712 |    -1.018 |   -0.2680 |
-#> |    U|     466.68962 |     92.46 |    -6.039 |   -0.9488 |    -2.078 |
-#> |.....................|    -4.529 |    0.2485 |     1.936 |   0.03184 |
-#> |.....................|    0.8115 |   0.06760 |    0.6803 |    0.6854 |
-#> |.....................|     1.499 |    0.9562 |    0.7392 |     1.941 |
-#> |    X|     466.68962 |     92.46 |  0.002385 |    0.2791 |    0.1251 |
-#> |.....................|   0.01079 |    0.5618 |     1.936 |   0.03184 |
-#> |.....................|    0.8115 |   0.06760 |    0.6803 |    0.6854 |
-#> |.....................|     1.499 |    0.9562 |    0.7392 |     1.941 |
-#> |    F| Forward Diff. |     6.342 |  0.001592 |   -0.2787 |  -0.05882 |
-#> |.....................|  0.004933 |  -0.02534 |   -0.4440 |   -0.5467 |
-#> |.....................|   -0.1484 |  -0.03146 |    0.4648 |    -1.264 |
-#> |.....................|   -0.3607 |   -0.2274 |   -0.5157 |   -0.1312 |
-#> |  139|     466.68314 |     1.015 |    -1.839 |   -0.9751 |   -0.8151 |
-#> |.....................|   -0.9166 |    -1.339 |     1.792 |    -1.792 |
-#> |.....................|   -0.9160 |   -0.5585 |   -0.9470 |    -1.115 |
-#> |.....................|   -0.5998 |   -0.8691 |    -1.016 |   -0.2676 |
-#> |    U|     466.68314 |     92.36 |    -6.039 |   -0.9476 |    -2.077 |
-#> |.....................|    -4.529 |    0.2501 |     1.937 |   0.03187 |
-#> |.....................|    0.8128 |   0.06763 |    0.6797 |    0.6853 |
-#> |.....................|     1.500 |    0.9582 |    0.7404 |     1.942 |
-#> |    X|     466.68314 |     92.36 |  0.002385 |    0.2794 |    0.1252 |
-#> |.....................|   0.01079 |    0.5622 |     1.937 |   0.03187 |
-#> |.....................|    0.8128 |   0.06763 |    0.6797 |    0.6853 |
-#> |.....................|     1.500 |    0.9582 |    0.7404 |     1.942 |
-#> |    F| Forward Diff. |    -4.258 |-0.0003497 |   -0.2788 |  -0.03383 |
-#> |.....................|   0.01408 |   0.02647 |   -0.2857 |   -0.5956 |
-#> |.....................|  -0.05089 |   0.05050 |    0.4395 |    0.8187 |
-#> |.....................|   -0.2669 |  -0.06868 |   -0.3694 |   -0.1159 |
-#> |  140|     466.67997 |     1.015 |    -1.839 |   -0.9739 |   -0.8142 |
-#> |.....................|   -0.9180 |    -1.339 |     1.794 |    -1.790 |
-#> |.....................|   -0.9137 |   -0.5623 |   -0.9494 |    -1.116 |
-#> |.....................|   -0.6002 |   -0.8690 |    -1.016 |   -0.2664 |
-#> |    U|     466.67997 |     92.38 |    -6.039 |   -0.9465 |    -2.077 |
-#> |.....................|    -4.531 |    0.2499 |     1.938 |   0.03191 |
-#> |.....................|    0.8138 |   0.06752 |    0.6779 |    0.6846 |
-#> |.....................|     1.499 |    0.9583 |    0.7410 |     1.943 |
-#> |    X|     466.67997 |     92.38 |  0.002385 |    0.2796 |    0.1254 |
-#> |.....................|   0.01078 |    0.5622 |     1.938 |   0.03191 |
-#> |.....................|    0.8138 |   0.06752 |    0.6779 |    0.6846 |
-#> |.....................|     1.499 |    0.9583 |    0.7410 |     1.943 |
-#> |    M|   Mixed Diff. |    -1.882 |-7.391e+04 |   -0.2259 |  -0.03295 |
-#> |.....................|  0.005718 |   0.01130 |   -0.3842 |   -0.4930 |
-#> |.....................|  -0.04972 |  -0.05953 |    0.5251 |    -1.398 |
-#> |.....................|   -0.3564 |  -0.08212 |   -0.3242 |   -0.1008 |
-#> |  141|     466.67997 |     1.015 |    -1.839 |   -0.9739 |   -0.8142 |
-#> |.....................|   -0.9180 |    -1.339 |     1.794 |    -1.790 |
-#> |.....................|   -0.9137 |   -0.5623 |   -0.9494 |    -1.116 |
-#> |.....................|   -0.6002 |   -0.8690 |    -1.016 |   -0.2664 |
-#> |    U|     466.67997 |     92.38 |    -6.039 |   -0.9465 |    -2.077 |
-#> |.....................|    -4.531 |    0.2499 |     1.938 |   0.03191 |
-#> |.....................|    0.8138 |   0.06752 |    0.6779 |    0.6846 |
-#> |.....................|     1.499 |    0.9583 |    0.7410 |     1.943 |
-#> |    X|     466.67997 |     92.38 |  0.002385 |    0.2796 |    0.1254 |
-#> |.....................|   0.01078 |    0.5622 |     1.938 |   0.03191 |
-#> |.....................|    0.8138 |   0.06752 |    0.6779 |    0.6846 |
-#> |.....................|     1.499 |    0.9583 |    0.7410 |     1.943 |
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-
-AIC(
-  f_nlmixr_sfo_sfo_focei_const$nm,
-  f_nlmixr_fomc_sfo_focei_const$nm,
-  f_nlmixr_dfop_sfo_focei_const$nm,
-  f_nlmixr_fomc_sfo_saem_obs$nm,
-  f_nlmixr_fomc_sfo_focei_obs$nm,
-  f_nlmixr_dfop_sfo_saem_obs$nm,
-  f_nlmixr_dfop_sfo_focei_obs$nm,
-  f_nlmixr_fomc_sfo_focei_tc$nm,
-  f_nlmixr_dfop_sfo_focei_tc$nm,
-  f_nlmixr_fomc_sfo_saem_obs_tc$nm,
-  f_nlmixr_fomc_sfo_focei_obs_tc$nm,
-  f_nlmixr_dfop_sfo_saem_obs_tc$nm,
-  f_nlmixr_dfop_sfo_focei_obs_tc$nm
-)
-#> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)
-#> 
-#> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)
-#> 
-#> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)
-#> 
-#> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)
-#> 
-#>                                   df       AIC
-#> f_nlmixr_sfo_sfo_focei_const$nm    9 1082.4605
-#> f_nlmixr_fomc_sfo_focei_const$nm  11  814.4261
-#> f_nlmixr_dfop_sfo_focei_const$nm  13  870.2659
-#> f_nlmixr_fomc_sfo_saem_obs$nm     12  788.8373
-#> f_nlmixr_fomc_sfo_focei_obs$nm    12  794.5194
-#> f_nlmixr_dfop_sfo_saem_obs$nm     14  815.0797
-#> f_nlmixr_dfop_sfo_focei_obs$nm    14  834.8474
-#> f_nlmixr_fomc_sfo_focei_tc$nm     12  812.3296
-#> f_nlmixr_dfop_sfo_focei_tc$nm     14  819.4103
-#> f_nlmixr_fomc_sfo_saem_obs_tc$nm  14  814.4248
-#> f_nlmixr_fomc_sfo_focei_obs_tc$nm 14  787.4355
-#> f_nlmixr_dfop_sfo_saem_obs_tc$nm  16  828.5143
-#> f_nlmixr_dfop_sfo_focei_obs_tc$nm 16  811.1191
-# Currently, FOMC-SFO with two-component error by variable fitted by focei gives the
-# lowest AIC
-plot(f_nlmixr_fomc_sfo_focei_obs_tc)
-
-summary(f_nlmixr_fomc_sfo_focei_obs_tc)
-#> nlmixr version used for fitting:    2.0.6 
-#> mkin version used for pre-fitting:  1.1.0 
-#> R version used for fitting:         4.1.2 
-#> Date of fit:     Mon Feb 28 14:50:18 2022 
-#> Date of summary: Mon Feb 28 14:51:57 2022 
-#> 
-#> Equations:
-#> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent
-#> d_A1/dt = + f_parent_to_A1 * (alpha/beta) * 1/((time/beta) + 1) *
-#>            parent - k_A1 * A1
-#> 
-#> Data:
-#> 170 observations of 2 variable(s) grouped in 5 datasets
-#> 
-#> Degradation model predictions using RxODE
-#> 
-#> Fitted in 18.08 s
-#> 
-#> Variance model: Two-component variance unique to each observed variable 
-#> 
-#> Mean of starting values for individual parameters:
-#>        parent_0        log_k_A1 f_parent_qlogis       log_alpha        log_beta 
-#>         93.1168         -5.3034         -0.9442         -0.1065          2.2909 
-#> 
-#> Mean of starting values for error model parameters:
-#> sigma_low_parent  rsd_high_parent     sigma_low_A1      rsd_high_A1 
-#>          1.15958          0.03005          1.15958          0.03005 
-#> 
-#> Fixed degradation parameter values:
-#> None
-#> 
-#> Results:
-#> 
-#> Likelihood calculated by focei  
-#>     AIC   BIC logLik
-#>   787.4 831.3 -379.7
-#> 
-#> Optimised parameters:
-#>                    est.   lower   upper
-#> parent_0        93.6717 91.2552 96.0882
-#> log_k_A1        -6.3199 -8.4468 -4.1930
-#> f_parent_qlogis -1.0089 -1.3823 -0.6356
-#> log_alpha       -0.1616 -0.6624  0.3392
-#> log_beta         2.2088  1.6800  2.7376
-#> 
-#> Correlation: 
-#>                 prnt_0 lg__A1 f_prn_ lg_lph
-#> log_k_A1         0.372                     
-#> f_parent_qlogis -0.786 -0.409              
-#> log_alpha        0.336  0.942 -0.306       
-#> log_beta        -0.399 -0.759  0.248 -0.555
-#> 
-#> Random effects (omega):
-#>                     eta.parent_0 eta.log_k_A1 eta.f_parent_qlogis eta.log_alpha
-#> eta.parent_0               4.391        0.000              0.0000        0.0000
-#> eta.log_k_A1               0.000        6.402              0.0000        0.0000
-#> eta.f_parent_qlogis        0.000        0.000              0.1584        0.0000
-#> eta.log_alpha              0.000        0.000              0.0000        0.3381
-#> eta.log_beta               0.000        0.000              0.0000        0.0000
-#>                     eta.log_beta
-#> eta.parent_0               0.000
-#> eta.log_k_A1               0.000
-#> eta.f_parent_qlogis        0.000
-#> eta.log_alpha              0.000
-#> eta.log_beta               0.358
-#> 
-#> Variance model:
-#> sigma_low_parent  rsd_high_parent     sigma_low_A1      rsd_high_A1 
-#>          2.35616          0.00153          0.63564          0.08639 
-#> 
-#> Backtransformed parameters:
-#>                   est.     lower   upper
-#> parent_0       93.6717 9.126e+01 96.0882
-#> k_A1            0.0018 2.146e-04  0.0151
-#> f_parent_to_A1  0.2672 2.006e-01  0.3462
-#> alpha           0.8508 5.156e-01  1.4038
-#> beta            9.1049 5.366e+00 15.4499
-#> 
-#> Resulting formation fractions:
-#>                 ff
-#> parent_A1   0.2672
-#> parent_sink 0.7328
-#> 
-#> Estimated disappearance times:
-#>          DT50   DT90 DT50back
-#> parent  11.46  127.3    38.31
-#> A1     385.05 1279.1       NA
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

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-
- -
- - - - - - - - diff --git a/docs/dev/reference/nobs.mkinfit.html b/docs/dev/reference/nobs.mkinfit.html deleted file mode 100644 index 10f6550b..00000000 --- a/docs/dev/reference/nobs.mkinfit.html +++ /dev/null @@ -1,157 +0,0 @@ - -Number of observations on which an mkinfit object was fitted — nobs.mkinfit • mkin - - -
-
- - - -
-
-
-

Number of observations on which an mkinfit object was fitted

- Source: R/nobs.mkinfit.R - -
- -
-

Number of observations on which an mkinfit object was fitted

-
- -
- 
# S3 method for mkinfit
-nobs(object, ...)
-
- -
-

Arguments

-
object
-

An mkinfit object

- - -
...
-

For compatibility with the generic method

- -
-
-

Value

- - -

The number of rows in the data included in the mkinfit object

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/parhist.html b/docs/dev/reference/parhist.html deleted file mode 100644 index 27fc116f..00000000 --- a/docs/dev/reference/parhist.html +++ /dev/null @@ -1,169 +0,0 @@ - -Plot parameter distributions from multistart objects — parhist • mkin - - -
-
- - - -
-
-
-

Plot parameter distributions from multistart objects

- Source: R/parhist.R - -
- -
-

Produces a boxplot with all parameters from the multiple runs, scaled -either by the parameters of the run with the highest likelihood, -or by their medians as proposed in the paper by Duchesne et al. (2021).

-
- -
- 
parhist(
-  object,
-  llmin = -Inf,
-  scale = c("best", "median"),
-  lpos = "bottomleft",
-  main = "",
-  ...
-)
-
- -
-

Arguments

-
object
-

The multistart object

- - -
llmin
-

The minimum likelihood of objects to be shown

- - -
scale
-

By default, scale parameters using the best available fit. -If 'median', parameters are scaled using the median parameters from all fits.

- - -
lpos
-

Positioning of the legend.

- - -
main
-

Title of the plot

- - -
...
-

Passed to boxplot

- -
-
-

References

-

Duchesne R, Guillemin A, Gandrillon O, Crauste F. Practical -identifiability in the frame of nonlinear mixed effects models: the example -of the in vitro erythropoiesis. BMC Bioinformatics. 2021 Oct 4;22(1):478. -doi: 10.1186/s12859-021-04373-4.

-
-
-

See also

-

multistart

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.6.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/parms.html b/docs/dev/reference/parms.html deleted file mode 100644 index d4175d41..00000000 --- a/docs/dev/reference/parms.html +++ /dev/null @@ -1,296 +0,0 @@ - -Extract model parameters — parms • mkin - - -
-
- - - -
-
-
-

Extract model parameters

- Source: R/parms.R, R/saem.R - -
- -
-

This function returns degradation model parameters as well as error -model parameters per default, in order to avoid working with a fitted model -without considering the error structure that was assumed for the fit.

-
- -
- 
parms(object, ...)
-
-# S3 method for mkinfit
-parms(object, transformed = FALSE, errparms = TRUE, ...)
-
-# S3 method for mmkin
-parms(object, transformed = FALSE, errparms = TRUE, ...)
-
-# S3 method for multistart
-parms(object, exclude_failed = TRUE, ...)
-
-# S3 method for saem.mmkin
-parms(object, ci = FALSE, covariates = NULL, ...)
-
- -
-

Arguments

-
object
-

A fitted model object.

- - -
...
-

Not used

- - -
transformed
-

Should the parameters be returned as used internally -during the optimisation?

- - -
errparms
-

Should the error model parameters be returned -in addition to the degradation parameters?

- - -
exclude_failed
-

For multistart objects, should rows for failed fits -be removed from the returned parameter matrix?

- - -
ci
-

Should a matrix with estimates and confidence interval boundaries -be returned? If FALSE (default), a vector of estimates is returned if no -covariates are given, otherwise a matrix of estimates is returned, with -each column corresponding to a row of the data frame holding the covariates

- - -
covariates
-

A data frame holding covariate values for which to -return parameter values. Only has an effect if 'ci' is FALSE.

- -
-
-

Value

- - -

Depending on the object, a numeric vector of fitted model parameters, -a matrix (e.g. for mmkin row objects), or a list of matrices (e.g. for -mmkin objects with more than one row).

-
-
-

See also

-

saem, multistart

-
- -
-

Examples

- 
# mkinfit objects
-fit <- mkinfit("SFO", FOCUS_2006_C, quiet = TRUE)
-parms(fit)
-#>   parent_0   k_parent      sigma 
-#> 82.4921598  0.3060633  4.6730124 
-parms(fit, transformed = TRUE)
-#>     parent_0 log_k_parent        sigma 
-#>    82.492160    -1.183963     4.673012 
-
-# mmkin objects
-ds <- lapply(experimental_data_for_UBA_2019[6:10],
- function(x) subset(x$data[c("name", "time", "value")]))
-names(ds) <- paste("Dataset", 6:10)
-# \dontrun{
-fits <- mmkin(c("SFO", "FOMC", "DFOP"), ds, quiet = TRUE, cores = 1)
-parms(fits["SFO", ])
-#>            Dataset 6    Dataset 7  Dataset 8  Dataset 9  Dataset 10
-#> parent_0 88.52275400 82.666781678 86.8547308 91.7779306 82.14809450
-#> k_parent  0.05794659  0.009647805  0.2102974  0.1232258  0.00720421
-#> sigma     5.15274487  7.040168584  3.6769645  6.4669234  6.50457673
-parms(fits[, 2])
-#> $SFO
-#>             Dataset 7
-#> parent_0 82.666781678
-#> k_parent  0.009647805
-#> sigma     7.040168584
-#> 
-#> $FOMC
-#>           Dataset 7
-#> parent_0 92.6837649
-#> alpha     0.4967832
-#> beta     14.1451255
-#> sigma     1.9167519
-#> 
-#> $DFOP
-#>             Dataset 7
-#> parent_0 91.058971589
-#> k1        0.044946770
-#> k2        0.002868336
-#> g         0.526942415
-#> sigma     2.221302196
-#> 
-parms(fits)
-#> $SFO
-#>            Dataset 6    Dataset 7  Dataset 8  Dataset 9  Dataset 10
-#> parent_0 88.52275400 82.666781678 86.8547308 91.7779306 82.14809450
-#> k_parent  0.05794659  0.009647805  0.2102974  0.1232258  0.00720421
-#> sigma     5.15274487  7.040168584  3.6769645  6.4669234  6.50457673
-#> 
-#> $FOMC
-#>          Dataset 6  Dataset 7 Dataset 8 Dataset 9 Dataset 10
-#> parent_0 95.558575 92.6837649 90.719787 98.383939 94.8481459
-#> alpha     1.338667  0.4967832  1.639099  1.074460  0.2805272
-#> beta     13.033315 14.1451255  5.007077  4.397126  6.9052224
-#> sigma     1.847671  1.9167519  1.066063  3.146056  1.6222778
-#> 
-#> $DFOP
-#>            Dataset 6    Dataset 7   Dataset 8   Dataset 9   Dataset 10
-#> parent_0 96.55213663 91.058971589 90.34509493 98.14858820 94.311323734
-#> k1        0.21954588  0.044946770  0.41232288  0.31697588  0.080663857
-#> k2        0.02957934  0.002868336  0.07581766  0.03260384  0.003425417
-#> g         0.44845068  0.526942415  0.66091967  0.65322767  0.342652880
-#> sigma     1.35690468  2.221302196  1.34169076  2.87159846  1.942067831
-#> 
-parms(fits, transformed = TRUE)
-#> $SFO
-#>              Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10
-#> parent_0     88.522754 82.666782 86.854731 91.777931  82.148094
-#> log_k_parent -2.848234 -4.641025 -1.559232 -2.093737  -4.933090
-#> sigma         5.152745  7.040169  3.676964  6.466923   6.504577
-#> 
-#> $FOMC
-#>            Dataset 6  Dataset 7  Dataset 8   Dataset 9 Dataset 10
-#> parent_0  95.5585751 92.6837649 90.7197870 98.38393897  94.848146
-#> log_alpha  0.2916741 -0.6996015  0.4941466  0.07181816  -1.271085
-#> log_beta   2.5675088  2.6493701  1.6108523  1.48095106   1.932278
-#> sigma      1.8476712  1.9167519  1.0660627  3.14605557   1.622278
-#> 
-#> $DFOP
-#>           Dataset 6  Dataset 7  Dataset 8  Dataset 9 Dataset 10
-#> parent_0 96.5521366 91.0589716 90.3450949 98.1485882 94.3113237
-#> log_k1   -1.5161940 -3.1022764 -0.8859486 -1.1489296 -2.5174647
-#> log_k2   -3.5206791 -5.8540232 -2.5794240 -3.4233253 -5.6765322
-#> g_qlogis -0.2069326  0.1078741  0.6673953  0.6332573 -0.6514943
-#> sigma     1.3569047  2.2213022  1.3416908  2.8715985  1.9420678
-#> 
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/parplot.html b/docs/dev/reference/parplot.html deleted file mode 100644 index ee2ec7b2..00000000 --- a/docs/dev/reference/parplot.html +++ /dev/null @@ -1,205 +0,0 @@ - -Plot parameter variability of multistart objects — parplot • mkin - - -
-
- - - -
-
-
-

Plot parameter variability of multistart objects

- Source: R/parplot.R - -
- -
-

Produces a boxplot with all parameters from the multiple runs, scaled -either by the parameters of the run with the highest likelihood, -or by their medians as proposed in the paper by Duchesne et al. (2021).

-
- -
- 
parplot(object, ...)
-
-# S3 method for multistart.saem.mmkin
-parplot(
-  object,
-  llmin = -Inf,
-  llquant = NA,
-  scale = c("best", "median"),
-  lpos = "bottomleft",
-  main = "",
-  ...
-)
-
- -
-

Arguments

-
object
-

The multistart object

- - -
...
-

Passed to boxplot

- - -
llmin
-

The minimum likelihood of objects to be shown

- - -
llquant
-

Fractional value for selecting only the fits with higher -likelihoods. Overrides 'llmin'.

- - -
scale
-

By default, scale parameters using the best -available fit. -If 'median', parameters are scaled using the median parameters from all fits.

- - -
lpos
-

Positioning of the legend.

- - -
main
-

Title of the plot

- -
-
-

Details

-

Starting values of degradation model parameters and error model parameters -are shown as green circles. The results obtained in the original run -are shown as red circles.

-
-
-

References

-

Duchesne R, Guillemin A, Gandrillon O, Crauste F. Practical -identifiability in the frame of nonlinear mixed effects models: the example -of the in vitro erythropoiesis. BMC Bioinformatics. 2021 Oct 4;22(1):478. -doi: 10.1186/s12859-021-04373-4.

-
-
-

See also

-

multistart

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/plot.mixed.mmkin-1.png b/docs/dev/reference/plot.mixed.mmkin-1.png deleted file mode 100644 index 2e145bb7..00000000 Binary files a/docs/dev/reference/plot.mixed.mmkin-1.png and /dev/null differ diff --git a/docs/dev/reference/plot.mixed.mmkin-2.png b/docs/dev/reference/plot.mixed.mmkin-2.png deleted file mode 100644 index b22c1dbb..00000000 Binary files a/docs/dev/reference/plot.mixed.mmkin-2.png and /dev/null differ diff --git a/docs/dev/reference/plot.mixed.mmkin-3.png b/docs/dev/reference/plot.mixed.mmkin-3.png deleted file mode 100644 index cd424bf2..00000000 Binary files a/docs/dev/reference/plot.mixed.mmkin-3.png and /dev/null differ diff --git a/docs/dev/reference/plot.mixed.mmkin-4.png b/docs/dev/reference/plot.mixed.mmkin-4.png deleted file mode 100644 index f6ffe4d5..00000000 Binary files a/docs/dev/reference/plot.mixed.mmkin-4.png and /dev/null differ diff --git a/docs/dev/reference/plot.mixed.mmkin.html b/docs/dev/reference/plot.mixed.mmkin.html deleted file mode 100644 index 3d902b77..00000000 --- a/docs/dev/reference/plot.mixed.mmkin.html +++ /dev/null @@ -1,342 +0,0 @@ - -Plot predictions from a fitted nonlinear mixed model obtained via an mmkin row object — plot.mixed.mmkin • mkin - - -
-
- - - -
-
-
-

Plot predictions from a fitted nonlinear mixed model obtained via an mmkin row object

- Source: R/plot.mixed.mmkin.R - -
- -
-

Plot predictions from a fitted nonlinear mixed model obtained via an mmkin row object

-
- -
- 
# S3 method for mixed.mmkin
-plot(
-  x,
-  i = 1:ncol(x$mmkin),
-  obs_vars = names(x$mkinmod$map),
-  standardized = TRUE,
-  covariates = NULL,
-  covariate_quantiles = c(0.5, 0.05, 0.95),
-  xlab = "Time",
-  xlim = range(x$data$time),
-  resplot = c("predicted", "time"),
-  pop_curves = "auto",
-  pred_over = NULL,
-  test_log_parms = FALSE,
-  conf.level = 0.6,
-  default_log_parms = NA,
-  ymax = "auto",
-  maxabs = "auto",
-  ncol.legend = ifelse(length(i) <= 3, length(i) + 1, ifelse(length(i) <= 8, 3, 4)),
-  nrow.legend = ceiling((length(i) + 1)/ncol.legend),
-  rel.height.legend = 0.02 + 0.07 * nrow.legend,
-  rel.height.bottom = 1.1,
-  pch_ds = 1:length(i),
-  col_ds = pch_ds + 1,
-  lty_ds = col_ds,
-  frame = TRUE,
-  ...
-)
-
- -
-

Arguments

-
x
-

An object of class mixed.mmkin, saem.mmkin or nlme.mmkin

- - -
i
-

A numeric index to select datasets for which to plot the individual predictions, -in case plots get too large

- - -
obs_vars
-

A character vector of names of the observed variables for -which the data and the model should be plotted. Defauls to all observed -variables in the model.

- - -
standardized
-

Should the residuals be standardized? Only takes effect if -resplot = "time".

- - -
covariates
-

Data frame with covariate values for all variables in -any covariate models in the object. If given, it overrides 'covariate_quantiles'. -Each line in the data frame will result in a line drawn for the population. -Rownames are used in the legend to label the lines.

- - -
covariate_quantiles
-

This argument only has an effect if the fitted -object has covariate models. If so, the default is to show three population -curves, for the 5th percentile, the 50th percentile and the 95th percentile -of the covariate values used for fitting the model.

- - -
xlab
-

Label for the x axis.

- - -
xlim
-

Plot range in x direction.

- - -
resplot
-

Should the residuals plotted against time or against -predicted values?

- - -
pop_curves
-

Per default, one population curve is drawn in case -population parameters are fitted by the model, e.g. for saem objects. -In case there is a covariate model, the behaviour depends on the value -of 'covariates'

- - -
pred_over
-

Named list of alternative predictions as obtained -from mkinpredict with a compatible mkinmod.

- - -
test_log_parms
-

Passed to mean_degparms in the case of an -mixed.mmkin object

- - -
conf.level
-

Passed to mean_degparms in the case of an -mixed.mmkin object

- - -
default_log_parms
-

Passed to mean_degparms in the case of an -mixed.mmkin object

- - -
ymax
-

Vector of maximum y axis values

- - -
maxabs
-

Maximum absolute value of the residuals. This is used for the -scaling of the y axis and defaults to "auto".

- - -
ncol.legend
-

Number of columns to use in the legend

- - -
nrow.legend
-

Number of rows to use in the legend

- - -
rel.height.legend
-

The relative height of the legend shown on top

- - -
rel.height.bottom
-

The relative height of the bottom plot row

- - -
pch_ds
-

Symbols to be used for plotting the data.

- - -
col_ds
-

Colors used for plotting the observed data and the -corresponding model prediction lines for the different datasets.

- - -
lty_ds
-

Line types to be used for the model predictions.

- - -
frame
-

Should a frame be drawn around the plots?

- - -
...
-

Further arguments passed to plot.

- -
-
-

Value

- - -

The function is called for its side effect.

-
-
-

Note

-

Covariate models are currently only supported for saem.mmkin objects.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 
ds <- lapply(experimental_data_for_UBA_2019[6:10],
- function(x) x$data[c("name", "time", "value")])
-names(ds) <- paste0("ds ", 6:10)
-dfop_sfo <- mkinmod(parent = mkinsub("DFOP", "A1"),
-  A1 = mkinsub("SFO"), quiet = TRUE)
-# \dontrun{
-f <- mmkin(list("DFOP-SFO" = dfop_sfo), ds, quiet = TRUE)
-plot(f[, 3:4], standardized = TRUE)
-
-
-# For this fit we need to increase pnlsMaxiter, and we increase the
-# tolerance in order to speed up the fit for this example evaluation
-# It still takes 20 seconds to run
-f_nlme <- nlme(f, control = list(pnlsMaxIter = 120, tolerance = 1e-3))
-plot(f_nlme)
-
-
-f_saem <- saem(f, transformations = "saemix")
-plot(f_saem)
-
-
-f_obs <- mmkin(list("DFOP-SFO" = dfop_sfo), ds, quiet = TRUE, error_model = "obs")
-f_nlmix <- nlmix(f_obs)
-#> Error in nlmix(f_obs): could not find function "nlmix"
-plot(f_nlmix)
-#> Error in plot(f_nlmix): object 'f_nlmix' not found
-
-# We can overlay the two variants if we generate predictions
-pred_nlme <- mkinpredict(dfop_sfo,
-  f_nlme$bparms.optim[-1],
-  c(parent = f_nlme$bparms.optim[[1]], A1 = 0),
-  seq(0, 180, by = 0.2))
-plot(f_saem, pred_over = list(nlme = pred_nlme))
-
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/plot.mkinfit-1.png b/docs/dev/reference/plot.mkinfit-1.png deleted file mode 100644 index a48ea72b..00000000 Binary files a/docs/dev/reference/plot.mkinfit-1.png and /dev/null differ diff --git a/docs/dev/reference/plot.mkinfit-2.png b/docs/dev/reference/plot.mkinfit-2.png deleted file mode 100644 index 4bc1815c..00000000 Binary files a/docs/dev/reference/plot.mkinfit-2.png and /dev/null differ diff --git a/docs/dev/reference/plot.mkinfit-3.png b/docs/dev/reference/plot.mkinfit-3.png deleted file mode 100644 index 8de1babc..00000000 Binary files a/docs/dev/reference/plot.mkinfit-3.png and /dev/null differ diff --git a/docs/dev/reference/plot.mkinfit-4.png b/docs/dev/reference/plot.mkinfit-4.png deleted file mode 100644 index 4b7a5f27..00000000 Binary files a/docs/dev/reference/plot.mkinfit-4.png and /dev/null differ diff --git a/docs/dev/reference/plot.mkinfit-5.png b/docs/dev/reference/plot.mkinfit-5.png deleted file mode 100644 index a8525aaa..00000000 Binary files a/docs/dev/reference/plot.mkinfit-5.png and /dev/null differ diff --git a/docs/dev/reference/plot.mkinfit-6.png b/docs/dev/reference/plot.mkinfit-6.png deleted file mode 100644 index 878e3dd6..00000000 Binary files a/docs/dev/reference/plot.mkinfit-6.png and /dev/null differ diff --git a/docs/dev/reference/plot.mkinfit-7.png b/docs/dev/reference/plot.mkinfit-7.png deleted file mode 100644 index c2537ea7..00000000 Binary files a/docs/dev/reference/plot.mkinfit-7.png and /dev/null differ diff --git a/docs/dev/reference/plot.mkinfit.html b/docs/dev/reference/plot.mkinfit.html deleted file mode 100644 index 9cf12d82..00000000 --- a/docs/dev/reference/plot.mkinfit.html +++ /dev/null @@ -1,367 +0,0 @@ - -Plot the observed data and the fitted model of an mkinfit object — plot.mkinfit • mkin - - -
-
- - - -
-
-
-

Plot the observed data and the fitted model of an mkinfit object

- Source: R/plot.mkinfit.R - -
- -
-

Solves the differential equations with the optimised and fixed parameters -from a previous successful call to mkinfit and plots the -observed data together with the solution of the fitted model.

-
- -
- 
# S3 method for mkinfit
-plot(
-  x,
-  fit = x,
-  obs_vars = names(fit$mkinmod$map),
-  xlab = "Time",
-  ylab = "Residue",
-  xlim = range(fit$data$time),
-  ylim = "default",
-  col_obs = 1:length(obs_vars),
-  pch_obs = col_obs,
-  lty_obs = rep(1, length(obs_vars)),
-  add = FALSE,
-  legend = !add,
-  show_residuals = FALSE,
-  show_errplot = FALSE,
-  maxabs = "auto",
-  sep_obs = FALSE,
-  rel.height.middle = 0.9,
-  row_layout = FALSE,
-  lpos = "topright",
-  inset = c(0.05, 0.05),
-  show_errmin = FALSE,
-  errmin_digits = 3,
-  frame = TRUE,
-  ...
-)
-
-plot_sep(
-  fit,
-  show_errmin = TRUE,
-  show_residuals = ifelse(identical(fit$err_mod, "const"), TRUE, "standardized"),
-  ...
-)
-
-plot_res(
-  fit,
-  sep_obs = FALSE,
-  show_errmin = sep_obs,
-  standardized = ifelse(identical(fit$err_mod, "const"), FALSE, TRUE),
-  ...
-)
-
-plot_err(fit, sep_obs = FALSE, show_errmin = sep_obs, ...)
-
- -
-

Arguments

-
x
-

Alias for fit introduced for compatibility with the generic S3 -method.

- - -
fit
-

An object of class mkinfit.

- - -
obs_vars
-

A character vector of names of the observed variables for -which the data and the model should be plotted. Defauls to all observed -variables in the model.

- - -
xlab
-

Label for the x axis.

- - -
ylab
-

Label for the y axis.

- - -
xlim
-

Plot range in x direction.

- - -
ylim
-

Plot range in y direction. If given as a list, plot ranges -for the different plot rows can be given for row layout.

- - -
col_obs
-

Colors used for plotting the observed data and the -corresponding model prediction lines.

- - -
pch_obs
-

Symbols to be used for plotting the data.

- - -
lty_obs
-

Line types to be used for the model predictions.

- - -
add
-

Should the plot be added to an existing plot?

- - -
legend
-

Should a legend be added to the plot?

- - -
show_residuals
-

Should residuals be shown? If only one plot of the -fits is shown, the residual plot is in the lower third of the plot. -Otherwise, i.e. if "sep_obs" is given, the residual plots will be located -to the right of the plots of the fitted curves. If this is set to -'standardized', a plot of the residuals divided by the standard deviation -given by the fitted error model will be shown.

- - -
show_errplot
-

Should squared residuals and the error model be shown? -If only one plot of the fits is shown, this plot is in the lower third of -the plot. Otherwise, i.e. if "sep_obs" is given, the residual plots will -be located to the right of the plots of the fitted curves.

- - -
maxabs
-

Maximum absolute value of the residuals. This is used for the -scaling of the y axis and defaults to "auto".

- - -
sep_obs
-

Should the observed variables be shown in separate subplots? -If yes, residual plots requested by "show_residuals" will be shown next -to, not below the plot of the fits.

- - -
rel.height.middle
-

The relative height of the middle plot, if more -than two rows of plots are shown.

- - -
row_layout
-

Should we use a row layout where the residual plot or the -error model plot is shown to the right?

- - -
lpos
-

Position(s) of the legend(s). Passed to legend as -the first argument. If not length one, this should be of the same length -as the obs_var argument.

- - -
inset
-

Passed to legend if applicable.

- - -
show_errmin
-

Should the FOCUS chi2 error value be shown in the upper -margin of the plot?

- - -
errmin_digits
-

The number of significant digits for rounding the FOCUS -chi2 error percentage.

- - -
frame
-

Should a frame be drawn around the plots?

- - -
...
-

Further arguments passed to plot.

- - -
standardized
-

When calling 'plot_res', should the residuals be -standardized in the residual plot?

- -
-
-

Value

- - -

The function is called for its side effect.

-
-
-

Details

-

If the current plot device is a tikz device, then -latex is being used for the formatting of the chi2 error level, if -show_errmin = TRUE.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-# One parent compound, one metabolite, both single first order, path from
-# parent to sink included
-# \dontrun{
-SFO_SFO <- mkinmod(parent = mkinsub("SFO", "m1", full = "Parent"),
-                   m1 = mkinsub("SFO", full = "Metabolite M1" ))
-#> Temporary DLL for differentials generated and loaded
-fit <- mkinfit(SFO_SFO, FOCUS_2006_D, quiet = TRUE)
-#> Warning: Observations with value of zero were removed from the data
-fit <- mkinfit(SFO_SFO, FOCUS_2006_D, quiet = TRUE, error_model = "tc")
-#> Warning: Observations with value of zero were removed from the data
-plot(fit)
-
-plot_res(fit)
-
-plot_res(fit, standardized = FALSE)
-
-plot_err(fit)
-
-
-# Show the observed variables separately, with residuals
-plot(fit, sep_obs = TRUE, show_residuals = TRUE, lpos = c("topright", "bottomright"),
-     show_errmin = TRUE)
-
-
-# The same can be obtained with less typing, using the convenience function plot_sep
-plot_sep(fit, lpos = c("topright", "bottomright"))
-
-
-# Show the observed variables separately, with the error model
-plot(fit, sep_obs = TRUE, show_errplot = TRUE, lpos = c("topright", "bottomright"),
-     show_errmin = TRUE)
-
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/plot.mmkin-1.png b/docs/dev/reference/plot.mmkin-1.png deleted file mode 100644 index c4fcb9ac..00000000 Binary files a/docs/dev/reference/plot.mmkin-1.png and /dev/null differ diff --git a/docs/dev/reference/plot.mmkin-2.png b/docs/dev/reference/plot.mmkin-2.png deleted file mode 100644 index 8cc727c3..00000000 Binary files a/docs/dev/reference/plot.mmkin-2.png and /dev/null differ diff --git a/docs/dev/reference/plot.mmkin-3.png b/docs/dev/reference/plot.mmkin-3.png deleted file mode 100644 index 066958c9..00000000 Binary files a/docs/dev/reference/plot.mmkin-3.png and /dev/null differ diff --git a/docs/dev/reference/plot.mmkin-4.png b/docs/dev/reference/plot.mmkin-4.png deleted file mode 100644 index c91410fa..00000000 Binary files a/docs/dev/reference/plot.mmkin-4.png and /dev/null differ diff --git a/docs/dev/reference/plot.mmkin-5.png b/docs/dev/reference/plot.mmkin-5.png deleted file mode 100644 index f0a03694..00000000 Binary files a/docs/dev/reference/plot.mmkin-5.png and /dev/null differ diff --git a/docs/dev/reference/plot.mmkin.html b/docs/dev/reference/plot.mmkin.html deleted file mode 100644 index c8fde67c..00000000 --- a/docs/dev/reference/plot.mmkin.html +++ /dev/null @@ -1,271 +0,0 @@ - -Plot model fits (observed and fitted) and the residuals for a row or column -of an mmkin object — plot.mmkin • mkin - - -
-
- - - -
-
-
-

Plot model fits (observed and fitted) and the residuals for a row or column -of an mmkin object

- Source: R/plot.mmkin.R - -
- -
-

When x is a row selected from an mmkin object ([.mmkin), the -same model fitted for at least one dataset is shown. When it is a column, -the fit of at least one model to the same dataset is shown.

-
- -
- 
# S3 method for mmkin
-plot(
-  x,
-  main = "auto",
-  legends = 1,
-  resplot = c("time", "errmod"),
-  ylab = "Residue",
-  standardized = FALSE,
-  show_errmin = TRUE,
-  errmin_var = "All data",
-  errmin_digits = 3,
-  cex = 0.7,
-  rel.height.middle = 0.9,
-  ymax = "auto",
-  ...
-)
-
- -
-

Arguments

-
x
-

An object of class mmkin, with either one row or one -column.

- - -
main
-

The main title placed on the outer margin of the plot.

- - -
legends
-

An index for the fits for which legends should be shown.

- - -
resplot
-

Should the residuals plotted against time, using -mkinresplot, or as squared residuals against predicted -values, with the error model, using mkinerrplot.

- - -
ylab
-

Label for the y axis.

- - -
standardized
-

Should the residuals be standardized? This option -is passed to mkinresplot, it only takes effect if -resplot = "time".

- - -
show_errmin
-

Should the chi2 error level be shown on top of the plots -to the left?

- - -
errmin_var
-

The variable for which the FOCUS chi2 error value should -be shown.

- - -
errmin_digits
-

The number of significant digits for rounding the FOCUS -chi2 error percentage.

- - -
cex
-

Passed to the plot functions and mtext.

- - -
rel.height.middle
-

The relative height of the middle plot, if more -than two rows of plots are shown.

- - -
ymax
-

Maximum y axis value for plot.mkinfit.

- - -
...
-

Further arguments passed to plot.mkinfit and -mkinresplot.

- -
-
-

Value

- - -

The function is called for its side effect.

-
-
-

Details

-

If the current plot device is a tikz device, then -latex is being used for the formatting of the chi2 error level.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-  # \dontrun{
-  # Only use one core not to offend CRAN checks
-  fits <- mmkin(c("FOMC", "HS"),
-                list("FOCUS B" = FOCUS_2006_B, "FOCUS C" = FOCUS_2006_C), # named list for titles
-                cores = 1, quiet = TRUE, error_model = "tc")
-#> Warning: Optimisation did not converge:
-#> iteration limit reached without convergence (10)
-  plot(fits[, "FOCUS C"])
-
-  plot(fits["FOMC", ])
-
-  plot(fits["FOMC", ], show_errmin = FALSE)
-
-
-  # We can also plot a single fit, if we like the way plot.mmkin works, but then the plot
-  # height should be smaller than the plot width (this is not possible for the html pages
-  # generated by pkgdown, as far as I know).
-  plot(fits["FOMC", "FOCUS C"]) # same as plot(fits[1, 2])
-
-
-  # Show the error models
-  plot(fits["FOMC", ], resplot = "errmod")
-
-  # }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/plot.nafta.html b/docs/dev/reference/plot.nafta.html deleted file mode 100644 index 8acaa8b3..00000000 --- a/docs/dev/reference/plot.nafta.html +++ /dev/null @@ -1,175 +0,0 @@ - -Plot the results of the three models used in the NAFTA scheme. — plot.nafta • mkin - - -
-
- - - -
-
-
-

Plot the results of the three models used in the NAFTA scheme.

- Source: R/nafta.R - -
- -
-

The plots are ordered with increasing complexity of the model in this -function (SFO, then IORE, then DFOP).

-
- -
- 
# S3 method for nafta
-plot(x, legend = FALSE, main = "auto", ...)
-
- -
-

Arguments

-
x
-

An object of class nafta.

- - -
legend
-

Should a legend be added?

- - -
main
-

Possibility to override the main title of the plot.

- - -
...
-

Further arguments passed to plot.mmkin.

- -
-
-

Value

- - -

The function is called for its side effect.

-
-
-

Details

-

Calls plot.mmkin.

-
-
-

Author

-

Johannes Ranke

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/print.mmkin.html b/docs/dev/reference/print.mmkin.html deleted file mode 100644 index 12c67d86..00000000 --- a/docs/dev/reference/print.mmkin.html +++ /dev/null @@ -1,194 +0,0 @@ - - - - - - - - -Print method for mmkin objects — print.mmkin • mkin - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
-
- - - - -
- -
-
-
-

Print method for mmkin objects

- Source: R/mmkin.R - -
- -
-

Print method for mmkin objects

-
- - 
# S3 method for mmkin
-print(x, ...)
- -

Arguments

- - - - - - - - - - -
x

An mmkin object.

...

Not used.

- - -
- -
- - -
-
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 1.6.1.

-
- -
-
- - - - - - - - diff --git a/docs/dev/reference/read_spreadsheet.html b/docs/dev/reference/read_spreadsheet.html deleted file mode 100644 index 6e7203f4..00000000 --- a/docs/dev/reference/read_spreadsheet.html +++ /dev/null @@ -1,196 +0,0 @@ - -Read datasets and relevant meta information from a spreadsheet file — read_spreadsheet • mkin - - -
-
- - - -
-
-
-

Read datasets and relevant meta information from a spreadsheet file

- Source: R/read_spreadsheet.R - -
- -
-

This function imports one dataset from each sheet of a spreadsheet file. -These sheets are selected based on the contents of a sheet 'Datasets', with -a column called 'Dataset Number', containing numbers identifying the dataset -sheets to be read in. In the second column there must be a grouping -variable, which will often be named 'Soil'. Optionally, time normalization -factors can be given in columns named 'Temperature' and 'Moisture'.

-
- -
- 
read_spreadsheet(
-  path,
-  valid_datasets = "all",
-  parent_only = FALSE,
-  normalize = TRUE
-)
-
- -
-

Arguments

-
path
-

Absolute or relative path to the spreadsheet file

- - -
valid_datasets
-

Optional numeric index of the valid datasets, default is -to use all datasets

- - -
parent_only
-

Should only the parent data be used?

- - -
normalize
-

Should the time scale be normalized using temperature -and moisture normalisation factors in the sheet 'Datasets'?

- -
-
-

Details

-

There must be a sheet 'Compounds', with columns 'Name' and 'Acronym'. -The first row read after the header read in from this sheet is assumed -to contain name and acronym of the parent compound.

-

The dataset sheets should be named using the dataset numbers read in from -the 'Datasets' sheet, i.e. '1', '2', ... . In each dataset sheet, name -of the observed variable (e.g. the acronym of the parent compound or -one of its transformation products) should be in the first column, -the time values should be in the second colum, and the observed value -in the third column.

-

In case relevant covariate data are available, they should be given -in a sheet 'Covariates', containing one line for each value of the grouping -variable specified in 'Datasets'. These values should be in the first -column and the column must have the same name as the second column in -'Datasets'. Covariates will be read in from columns four and higher. -Their names should preferably not contain special characters like spaces, -so they can be easily used for specifying covariate models.

-

An similar data structure is defined as the R6 class mkindsg, but -is probably more complicated to use.

-
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/reexports.html b/docs/dev/reference/reexports.html deleted file mode 100644 index ee1148da..00000000 --- a/docs/dev/reference/reexports.html +++ /dev/null @@ -1,157 +0,0 @@ - -Objects exported from other packages — reexports • mkin - - -
-
- - - -
-
-
-

Objects exported from other packages

- Source: R/intervals.R, R/lrtest.mkinfit.R, R/nlme.mmkin.R - -
- -
-

These objects are imported from other packages. Follow the links -below to see their documentation.

-
lmtest
-

lrtest

- - -
nlme
-

intervals, nlme

- - -
- - - -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/residuals.mkinfit.html b/docs/dev/reference/residuals.mkinfit.html deleted file mode 100644 index 578b5066..00000000 --- a/docs/dev/reference/residuals.mkinfit.html +++ /dev/null @@ -1,167 +0,0 @@ - -Extract residuals from an mkinfit model — residuals.mkinfit • mkin - - -
-
- - - -
-
-
-

Extract residuals from an mkinfit model

- Source: R/residuals.mkinfit.R - -
- -
-

Extract residuals from an mkinfit model

-
- -
- 
# S3 method for mkinfit
-residuals(object, standardized = FALSE, ...)
-
- -
-

Arguments

-
object
-

A mkinfit object

- - -
standardized
-

Should the residuals be standardized by dividing by the -standard deviation obtained from the fitted error model?

- - -
...
-

Not used

- -
- -
-

Examples

- 
f <- mkinfit("DFOP", FOCUS_2006_C, quiet = TRUE)
-residuals(f)
-#> [1]  0.09726374 -0.13912142 -0.15351210  0.73388322 -0.08657004 -0.93204702
-#> [7] -0.03269080  1.45347823 -0.88423697
-residuals(f, standardized = TRUE)
-#> [1]  0.13969917 -0.19981904 -0.22048826  1.05407091 -0.12433989 -1.33869208
-#> [7] -0.04695355  2.08761977 -1.27002287
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/saem-1.png b/docs/dev/reference/saem-1.png deleted file mode 100644 index 1fa206c4..00000000 Binary files a/docs/dev/reference/saem-1.png and /dev/null differ diff --git a/docs/dev/reference/saem-2.png b/docs/dev/reference/saem-2.png deleted file mode 100644 index e5c62c35..00000000 Binary files a/docs/dev/reference/saem-2.png and /dev/null differ diff --git a/docs/dev/reference/saem-3.png b/docs/dev/reference/saem-3.png deleted file mode 100644 index f191ad3a..00000000 Binary files a/docs/dev/reference/saem-3.png and /dev/null differ diff --git a/docs/dev/reference/saem-4.png b/docs/dev/reference/saem-4.png deleted file mode 100644 index a74e21f8..00000000 Binary files a/docs/dev/reference/saem-4.png and /dev/null differ diff --git a/docs/dev/reference/saem-5.png b/docs/dev/reference/saem-5.png deleted file mode 100644 index d22e7285..00000000 Binary files a/docs/dev/reference/saem-5.png and /dev/null differ diff --git a/docs/dev/reference/saem-6.png b/docs/dev/reference/saem-6.png deleted file mode 100644 index 314f9cd9..00000000 Binary files a/docs/dev/reference/saem-6.png and /dev/null differ diff --git a/docs/dev/reference/saem.html b/docs/dev/reference/saem.html deleted file mode 100644 index 9b9a911d..00000000 --- a/docs/dev/reference/saem.html +++ /dev/null @@ -1,779 +0,0 @@ - -Fit nonlinear mixed models with SAEM — saem • mkin - - -
-
- - - -
-
-
-

Fit nonlinear mixed models with SAEM

- Source: R/saem.R - -
- -
-

This function uses saemix::saemix() as a backend for fitting nonlinear mixed -effects models created from mmkin row objects using the Stochastic Approximation -Expectation Maximisation algorithm (SAEM).

-
- -
- 
saem(object, ...)
-
-# S3 method for mmkin
-saem(
-  object,
-  transformations = c("mkin", "saemix"),
-  error_model = "auto",
-  degparms_start = numeric(),
-  test_log_parms = TRUE,
-  conf.level = 0.6,
-  solution_type = "auto",
-  covariance.model = "auto",
-  omega.init = "auto",
-  covariates = NULL,
-  covariate_models = NULL,
-  no_random_effect = NULL,
-  error.init = c(1, 1),
-  nbiter.saemix = c(300, 100),
-  control = list(displayProgress = FALSE, print = FALSE, nbiter.saemix = nbiter.saemix,
-    save = FALSE, save.graphs = FALSE),
-  verbose = FALSE,
-  quiet = FALSE,
-  ...
-)
-
-# S3 method for saem.mmkin
-print(x, digits = max(3, getOption("digits") - 3), ...)
-
-saemix_model(
-  object,
-  solution_type = "auto",
-  transformations = c("mkin", "saemix"),
-  error_model = "auto",
-  degparms_start = numeric(),
-  covariance.model = "auto",
-  no_random_effect = NULL,
-  omega.init = "auto",
-  covariates = NULL,
-  covariate_models = NULL,
-  error.init = numeric(),
-  test_log_parms = FALSE,
-  conf.level = 0.6,
-  verbose = FALSE,
-  ...
-)
-
-saemix_data(object, covariates = NULL, verbose = FALSE, ...)
-
- -
-

Arguments

-
object
-

An mmkin row object containing several fits of the same -mkinmod model to different datasets

- - -
...
-

Further parameters passed to saemix::saemixModel.

- - -
transformations
-

Per default, all parameter transformations are done -in mkin. If this argument is set to 'saemix', parameter transformations -are done in 'saemix' for the supported cases, i.e. (as of version 1.1.2) -SFO, FOMC, DFOP and HS without fixing parent_0, and SFO or DFOP with -one SFO metabolite.

- - -
error_model
-

Possibility to override the error model used in the mmkin object

- - -
degparms_start
-

Parameter values given as a named numeric vector will -be used to override the starting values obtained from the 'mmkin' object.

- - -
test_log_parms
-

If TRUE, an attempt is made to use more robust starting -values for population parameters fitted as log parameters in mkin (like -rate constants) by only considering rate constants that pass the t-test -when calculating mean degradation parameters using mean_degparms.

- - -
conf.level
-

Possibility to adjust the required confidence level -for parameter that are tested if requested by 'test_log_parms'.

- - -
solution_type
-

Possibility to specify the solution type in case the -automatic choice is not desired

- - -
covariance.model
-

Will be passed to saemix::saemixModel(). Per -default, uncorrelated random effects are specified for all degradation -parameters.

- - -
omega.init
-

Will be passed to saemix::saemixModel(). If using -mkin transformations and the default covariance model with optionally -excluded random effects, the variances of the degradation parameters -are estimated using mean_degparms, with testing of untransformed -log parameters for significant difference from zero. If not using -mkin transformations or a custom covariance model, the default -initialisation of saemix::saemixModel is used for omega.init.

- - -
covariates
-

A data frame with covariate data for use in -'covariate_models', with dataset names as row names.

- - -
covariate_models
-

A list containing linear model formulas with one explanatory -variable, i.e. of the type 'parameter ~ covariate'. Covariates must be available -in the 'covariates' data frame.

- - -
no_random_effect
-

Character vector of degradation parameters for -which there should be no variability over the groups. Only used -if the covariance model is not explicitly specified.

- - -
error.init
-

Will be passed to saemix::saemixModel().

- - -
nbiter.saemix
-

Convenience option to increase the number of -iterations

- - -
control
-

Passed to saemix::saemix.

- - -
verbose
-

Should we print information about created objects of -type saemix::SaemixModel and saemix::SaemixData?

- - -
quiet
-

Should we suppress the messages saemix prints at the beginning -and the end of the optimisation process?

- - -
x
-

An saem.mmkin object to print

- - -
digits
-

Number of digits to use for printing

- -
-
-

Value

- - -

An S3 object of class 'saem.mmkin', containing the fitted -saemix::SaemixObject as a list component named 'so'. The -object also inherits from 'mixed.mmkin'.

- - -

An saemix::SaemixModel object.

- - -

An saemix::SaemixData object.

-
-
-

Details

-

An mmkin row object is essentially a list of mkinfit objects that have been -obtained by fitting the same model to a list of datasets using mkinfit.

-

Starting values for the fixed effects (population mean parameters, argument -psi0 of saemix::saemixModel() are the mean values of the parameters found -using mmkin.

-
- - -
-

Examples

- 
# \dontrun{
-ds <- lapply(experimental_data_for_UBA_2019[6:10],
- function(x) subset(x$data[c("name", "time", "value")]))
-names(ds) <- paste("Dataset", 6:10)
-f_mmkin_parent_p0_fixed <- mmkin("FOMC", ds,
-  state.ini = c(parent = 100), fixed_initials = "parent", quiet = TRUE)
-f_saem_p0_fixed <- saem(f_mmkin_parent_p0_fixed)
-
-f_mmkin_parent <- mmkin(c("SFO", "FOMC", "DFOP"), ds, quiet = TRUE)
-f_saem_sfo <- saem(f_mmkin_parent["SFO", ])
-f_saem_fomc <- saem(f_mmkin_parent["FOMC", ])
-f_saem_dfop <- saem(f_mmkin_parent["DFOP", ])
-anova(f_saem_sfo, f_saem_fomc, f_saem_dfop)
-#> Data: 90 observations of 1 variable(s) grouped in 5 datasets
-#> 
-#>             npar    AIC    BIC     Lik
-#> f_saem_sfo     5 624.33 622.38 -307.17
-#> f_saem_fomc    7 467.85 465.11 -226.92
-#> f_saem_dfop    9 493.76 490.24 -237.88
-anova(f_saem_sfo, f_saem_dfop, test = TRUE)
-#> Data: 90 observations of 1 variable(s) grouped in 5 datasets
-#> 
-#>             npar    AIC    BIC     Lik  Chisq Df Pr(>Chisq)    
-#> f_saem_sfo     5 624.33 622.38 -307.17                         
-#> f_saem_dfop    9 493.76 490.24 -237.88 138.57  4  < 2.2e-16 ***
-#> ---
-#> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
-illparms(f_saem_dfop)
-#> [1] "sd(g_qlogis)"
-f_saem_dfop_red <- update(f_saem_dfop, no_random_effect = "g_qlogis")
-anova(f_saem_dfop, f_saem_dfop_red, test = TRUE)
-#> Data: 90 observations of 1 variable(s) grouped in 5 datasets
-#> 
-#>                 npar    AIC    BIC     Lik Chisq Df Pr(>Chisq)
-#> f_saem_dfop_red    8 488.68 485.55 -236.34                    
-#> f_saem_dfop        9 493.76 490.24 -237.88     0  1          1
-
-anova(f_saem_sfo, f_saem_fomc, f_saem_dfop)
-#> Data: 90 observations of 1 variable(s) grouped in 5 datasets
-#> 
-#>             npar    AIC    BIC     Lik
-#> f_saem_sfo     5 624.33 622.38 -307.17
-#> f_saem_fomc    7 467.85 465.11 -226.92
-#> f_saem_dfop    9 493.76 490.24 -237.88
-# The returned saem.mmkin object contains an SaemixObject, therefore we can use
-# functions from saemix
-library(saemix)
-#> Loading required package: npde
-#> Package saemix, version 3.2
-#>   please direct bugs, questions and feedback to emmanuelle.comets@inserm.fr
-#> 
-#> Attaching package: ‘saemix’
-#> The following objects are masked from ‘package:npde’:
-#> 
-#>     kurtosis, skewness
-compare.saemix(f_saem_sfo$so, f_saem_fomc$so, f_saem_dfop$so)
-#> Likelihoods calculated by importance sampling
-#>        AIC      BIC
-#> 1 624.3316 622.3788
-#> 2 467.8472 465.1132
-#> 3 493.7592 490.2441
-plot(f_saem_fomc$so, plot.type = "convergence")
-
-plot(f_saem_fomc$so, plot.type = "individual.fit")
-
-plot(f_saem_fomc$so, plot.type = "npde")
-#> Simulating data using nsim = 1000 simulated datasets
-#> Computing WRES and npde .
-#> Please use npdeSaemix to obtain VPC and npde
-plot(f_saem_fomc$so, plot.type = "vpc")
-
-
-f_mmkin_parent_tc <- update(f_mmkin_parent, error_model = "tc")
-f_saem_fomc_tc <- saem(f_mmkin_parent_tc["FOMC", ])
-anova(f_saem_fomc, f_saem_fomc_tc, test = TRUE)
-#> Data: 90 observations of 1 variable(s) grouped in 5 datasets
-#> 
-#>                npar    AIC    BIC     Lik Chisq Df Pr(>Chisq)
-#> f_saem_fomc       7 467.85 465.11 -226.92                    
-#> f_saem_fomc_tc    8 469.83 466.71 -226.92 0.015  1     0.9027
-
-sfo_sfo <- mkinmod(parent = mkinsub("SFO", "A1"),
-  A1 = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-fomc_sfo <- mkinmod(parent = mkinsub("FOMC", "A1"),
-  A1 = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-dfop_sfo <- mkinmod(parent = mkinsub("DFOP", "A1"),
-  A1 = mkinsub("SFO"))
-#> Temporary DLL for differentials generated and loaded
-# The following fit uses analytical solutions for SFO-SFO and DFOP-SFO,
-# and compiled ODEs for FOMC that are much slower
-f_mmkin <- mmkin(list(
-    "SFO-SFO" = sfo_sfo, "FOMC-SFO" = fomc_sfo, "DFOP-SFO" = dfop_sfo),
-  ds, quiet = TRUE)
-# saem fits of SFO-SFO and DFOP-SFO to these data take about five seconds
-# each on this system, as we use analytical solutions written for saemix.
-# When using the analytical solutions written for mkin this took around
-# four minutes
-f_saem_sfo_sfo <- saem(f_mmkin["SFO-SFO", ])
-f_saem_dfop_sfo <- saem(f_mmkin["DFOP-SFO", ])
-# We can use print, plot and summary methods to check the results
-print(f_saem_dfop_sfo)
-#> Kinetic nonlinear mixed-effects model fit by SAEM
-#> Structural model:
-#> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
-#>            time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
-#>            * parent
-#> d_A1/dt = + f_parent_to_A1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)
-#>            * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *
-#>            exp(-k2 * time))) * parent - k_A1 * A1
-#> 
-#> Data:
-#> 170 observations of 2 variable(s) grouped in 5 datasets
-#> 
-#> Likelihood computed by importance sampling
-#>     AIC   BIC logLik
-#>   839.2 834.1 -406.6
-#> 
-#> Fitted parameters:
-#>                    estimate    lower   upper
-#> parent_0           93.70402 91.04104 96.3670
-#> log_k_A1           -5.83760 -7.66452 -4.0107
-#> f_parent_qlogis    -0.95718 -1.35955 -0.5548
-#> log_k1             -2.35514 -3.39402 -1.3163
-#> log_k2             -3.79634 -5.64009 -1.9526
-#> g_qlogis           -0.02108 -0.66463  0.6225
-#> a.1                 1.88191  1.66491  2.0989
-#> SD.parent_0         2.81628  0.78922  4.8433
-#> SD.log_k_A1         1.78751  0.42105  3.1540
-#> SD.f_parent_qlogis  0.45016  0.16116  0.7391
-#> SD.log_k1           1.06923  0.31676  1.8217
-#> SD.log_k2           2.03768  0.70938  3.3660
-#> SD.g_qlogis         0.44024 -0.09262  0.9731
-plot(f_saem_dfop_sfo)
-
-summary(f_saem_dfop_sfo, data = TRUE)
-#> saemix version used for fitting:      3.2 
-#> mkin version used for pre-fitting:  1.2.3 
-#> R version used for fitting:         4.2.3 
-#> Date of fit:     Sun Apr 16 08:32:32 2023 
-#> Date of summary: Sun Apr 16 08:32:32 2023 
-#> 
-#> Equations:
-#> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
-#>            time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
-#>            * parent
-#> d_A1/dt = + f_parent_to_A1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)
-#>            * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *
-#>            exp(-k2 * time))) * parent - k_A1 * A1
-#> 
-#> Data:
-#> 170 observations of 2 variable(s) grouped in 5 datasets
-#> 
-#> Model predictions using solution type analytical 
-#> 
-#> Fitted in 4.145 s
-#> Using 300, 100 iterations and 10 chains
-#> 
-#> Variance model: Constant variance 
-#> 
-#> Starting values for degradation parameters:
-#>        parent_0        log_k_A1 f_parent_qlogis          log_k1          log_k2 
-#>         93.8102         -5.3734         -0.9711         -1.8799         -4.2708 
-#>        g_qlogis 
-#>          0.1356 
-#> 
-#> Fixed degradation parameter values:
-#> None
-#> 
-#> Starting values for random effects (square root of initial entries in omega):
-#>                 parent_0 log_k_A1 f_parent_qlogis log_k1 log_k2 g_qlogis
-#> parent_0           4.941    0.000          0.0000  0.000  0.000   0.0000
-#> log_k_A1           0.000    2.551          0.0000  0.000  0.000   0.0000
-#> f_parent_qlogis    0.000    0.000          0.7251  0.000  0.000   0.0000
-#> log_k1             0.000    0.000          0.0000  1.449  0.000   0.0000
-#> log_k2             0.000    0.000          0.0000  0.000  2.228   0.0000
-#> g_qlogis           0.000    0.000          0.0000  0.000  0.000   0.7814
-#> 
-#> Starting values for error model parameters:
-#> a.1 
-#>   1 
-#> 
-#> Results:
-#> 
-#> Likelihood computed by importance sampling
-#>     AIC   BIC logLik
-#>   839.2 834.1 -406.6
-#> 
-#> Optimised parameters:
-#>                        est.    lower   upper
-#> parent_0           93.70402 91.04104 96.3670
-#> log_k_A1           -5.83760 -7.66452 -4.0107
-#> f_parent_qlogis    -0.95718 -1.35955 -0.5548
-#> log_k1             -2.35514 -3.39402 -1.3163
-#> log_k2             -3.79634 -5.64009 -1.9526
-#> g_qlogis           -0.02108 -0.66463  0.6225
-#> a.1                 1.88191  1.66491  2.0989
-#> SD.parent_0         2.81628  0.78922  4.8433
-#> SD.log_k_A1         1.78751  0.42105  3.1540
-#> SD.f_parent_qlogis  0.45016  0.16116  0.7391
-#> SD.log_k1           1.06923  0.31676  1.8217
-#> SD.log_k2           2.03768  0.70938  3.3660
-#> SD.g_qlogis         0.44024 -0.09262  0.9731
-#> 
-#> Correlation: 
-#>                 parnt_0 lg_k_A1 f_prnt_ log_k1  log_k2 
-#> log_k_A1        -0.0147                                
-#> f_parent_qlogis -0.0269  0.0573                        
-#> log_k1           0.0263 -0.0011 -0.0040                
-#> log_k2           0.0020  0.0065 -0.0002 -0.0776        
-#> g_qlogis        -0.0248 -0.0180 -0.0004 -0.0903 -0.0603
-#> 
-#> Random effects:
-#>                      est.    lower  upper
-#> SD.parent_0        2.8163  0.78922 4.8433
-#> SD.log_k_A1        1.7875  0.42105 3.1540
-#> SD.f_parent_qlogis 0.4502  0.16116 0.7391
-#> SD.log_k1          1.0692  0.31676 1.8217
-#> SD.log_k2          2.0377  0.70938 3.3660
-#> SD.g_qlogis        0.4402 -0.09262 0.9731
-#> 
-#> Variance model:
-#>      est. lower upper
-#> a.1 1.882 1.665 2.099
-#> 
-#> Backtransformed parameters:
-#>                     est.     lower    upper
-#> parent_0       93.704015 9.104e+01 96.36699
-#> k_A1            0.002916 4.692e-04  0.01812
-#> f_parent_to_A1  0.277443 2.043e-01  0.36475
-#> k1              0.094880 3.357e-02  0.26813
-#> k2              0.022453 3.553e-03  0.14191
-#> g               0.494731 3.397e-01  0.65078
-#> 
-#> Resulting formation fractions:
-#>                 ff
-#> parent_A1   0.2774
-#> parent_sink 0.7226
-#> 
-#> Estimated disappearance times:
-#>         DT50   DT90 DT50back DT50_k1 DT50_k2
-#> parent  14.0  72.38    21.79   7.306   30.87
-#> A1     237.7 789.68       NA      NA      NA
-#> 
-#> Data:
-#>          ds   name time observed predicted residual   std standardized
-#>   Dataset 6 parent    0     97.2  95.70025  1.49975 1.882      0.79693
-#>   Dataset 6 parent    0     96.4  95.70025  0.69975 1.882      0.37183
-#>   Dataset 6 parent    3     71.1  71.44670 -0.34670 1.882     -0.18423
-#>   Dataset 6 parent    3     69.2  71.44670 -2.24670 1.882     -1.19384
-#>   Dataset 6 parent    6     58.1  56.59283  1.50717 1.882      0.80087
-#>   Dataset 6 parent    6     56.6  56.59283  0.00717 1.882      0.00381
-#>   Dataset 6 parent   10     44.4  44.56648 -0.16648 1.882     -0.08847
-#>   Dataset 6 parent   10     43.4  44.56648 -1.16648 1.882     -0.61984
-#>   Dataset 6 parent   20     33.3  29.76020  3.53980 1.882      1.88096
-#>   Dataset 6 parent   20     29.2  29.76020 -0.56020 1.882     -0.29767
-#>   Dataset 6 parent   34     17.6  19.39208 -1.79208 1.882     -0.95226
-#>   Dataset 6 parent   34     18.0  19.39208 -1.39208 1.882     -0.73971
-#>   Dataset 6 parent   55     10.5  10.55761 -0.05761 1.882     -0.03061
-#>   Dataset 6 parent   55      9.3  10.55761 -1.25761 1.882     -0.66826
-#>   Dataset 6 parent   90      4.5   3.84742  0.65258 1.882      0.34676
-#>   Dataset 6 parent   90      4.7   3.84742  0.85258 1.882      0.45304
-#>   Dataset 6 parent  112      3.0   2.03997  0.96003 1.882      0.51013
-#>   Dataset 6 parent  112      3.4   2.03997  1.36003 1.882      0.72268
-#>   Dataset 6 parent  132      2.3   1.14585  1.15415 1.882      0.61328
-#>   Dataset 6 parent  132      2.7   1.14585  1.55415 1.882      0.82583
-#>   Dataset 6     A1    3      4.3   4.86054 -0.56054 1.882     -0.29786
-#>   Dataset 6     A1    3      4.6   4.86054 -0.26054 1.882     -0.13844
-#>   Dataset 6     A1    6      7.0   7.74179 -0.74179 1.882     -0.39417
-#>   Dataset 6     A1    6      7.2   7.74179 -0.54179 1.882     -0.28789
-#>   Dataset 6     A1   10      8.2   9.94048 -1.74048 1.882     -0.92485
-#>   Dataset 6     A1   10      8.0   9.94048 -1.94048 1.882     -1.03112
-#>   Dataset 6     A1   20     11.0  12.19109 -1.19109 1.882     -0.63291
-#>   Dataset 6     A1   20     13.7  12.19109  1.50891 1.882      0.80180
-#>   Dataset 6     A1   34     11.5  13.10706 -1.60706 1.882     -0.85395
-#>   Dataset 6     A1   34     12.7  13.10706 -0.40706 1.882     -0.21630
-#>   Dataset 6     A1   55     14.9  13.06131  1.83869 1.882      0.97703
-#>   Dataset 6     A1   55     14.5  13.06131  1.43869 1.882      0.76448
-#>   Dataset 6     A1   90     12.1  11.54495  0.55505 1.882      0.29494
-#>   Dataset 6     A1   90     12.3  11.54495  0.75505 1.882      0.40122
-#>   Dataset 6     A1  112      9.9  10.31533 -0.41533 1.882     -0.22070
-#>   Dataset 6     A1  112     10.2  10.31533 -0.11533 1.882     -0.06128
-#>   Dataset 6     A1  132      8.8   9.20222 -0.40222 1.882     -0.21373
-#>   Dataset 6     A1  132      7.8   9.20222 -1.40222 1.882     -0.74510
-#>   Dataset 7 parent    0     93.6  90.82357  2.77643 1.882      1.47532
-#>   Dataset 7 parent    0     92.3  90.82357  1.47643 1.882      0.78453
-#>   Dataset 7 parent    3     87.0  84.73448  2.26552 1.882      1.20384
-#>   Dataset 7 parent    3     82.2  84.73448 -2.53448 1.882     -1.34675
-#>   Dataset 7 parent    7     74.0  77.65013 -3.65013 1.882     -1.93958
-#>   Dataset 7 parent    7     73.9  77.65013 -3.75013 1.882     -1.99272
-#>   Dataset 7 parent   14     64.2  67.60639 -3.40639 1.882     -1.81007
-#>   Dataset 7 parent   14     69.5  67.60639  1.89361 1.882      1.00621
-#>   Dataset 7 parent   30     54.0  52.53663  1.46337 1.882      0.77760
-#>   Dataset 7 parent   30     54.6  52.53663  2.06337 1.882      1.09642
-#>   Dataset 7 parent   60     41.1  39.42728  1.67272 1.882      0.88884
-#>   Dataset 7 parent   60     38.4  39.42728 -1.02728 1.882     -0.54587
-#>   Dataset 7 parent   90     32.5  33.76360 -1.26360 1.882     -0.67144
-#>   Dataset 7 parent   90     35.5  33.76360  1.73640 1.882      0.92268
-#>   Dataset 7 parent  120     28.1  30.39975 -2.29975 1.882     -1.22203
-#>   Dataset 7 parent  120     29.0  30.39975 -1.39975 1.882     -0.74379
-#>   Dataset 7 parent  180     26.5  25.62379  0.87621 1.882      0.46559
-#>   Dataset 7 parent  180     27.6  25.62379  1.97621 1.882      1.05010
-#>   Dataset 7     A1    3      3.9   2.70005  1.19995 1.882      0.63762
-#>   Dataset 7     A1    3      3.1   2.70005  0.39995 1.882      0.21252
-#>   Dataset 7     A1    7      6.9   5.83475  1.06525 1.882      0.56605
-#>   Dataset 7     A1    7      6.6   5.83475  0.76525 1.882      0.40663
-#>   Dataset 7     A1   14     10.4  10.26142  0.13858 1.882      0.07364
-#>   Dataset 7     A1   14      8.3  10.26142 -1.96142 1.882     -1.04225
-#>   Dataset 7     A1   30     14.4  16.82999 -2.42999 1.882     -1.29123
-#>   Dataset 7     A1   30     13.7  16.82999 -3.12999 1.882     -1.66319
-#>   Dataset 7     A1   60     22.1  22.32486 -0.22486 1.882     -0.11949
-#>   Dataset 7     A1   60     22.3  22.32486 -0.02486 1.882     -0.01321
-#>   Dataset 7     A1   90     27.5  24.45927  3.04073 1.882      1.61576
-#>   Dataset 7     A1   90     25.4  24.45927  0.94073 1.882      0.49988
-#>   Dataset 7     A1  120     28.0  25.54862  2.45138 1.882      1.30260
-#>   Dataset 7     A1  120     26.6  25.54862  1.05138 1.882      0.55868
-#>   Dataset 7     A1  180     25.8  26.82277 -1.02277 1.882     -0.54347
-#>   Dataset 7     A1  180     25.3  26.82277 -1.52277 1.882     -0.80916
-#>   Dataset 8 parent    0     91.9  91.16791  0.73209 1.882      0.38901
-#>   Dataset 8 parent    0     90.8  91.16791 -0.36791 1.882     -0.19550
-#>   Dataset 8 parent    1     64.9  67.58358 -2.68358 1.882     -1.42598
-#>   Dataset 8 parent    1     66.2  67.58358 -1.38358 1.882     -0.73520
-#>   Dataset 8 parent    3     43.5  41.62086  1.87914 1.882      0.99853
-#>   Dataset 8 parent    3     44.1  41.62086  2.47914 1.882      1.31735
-#>   Dataset 8 parent    8     18.3  19.60116 -1.30116 1.882     -0.69140
-#>   Dataset 8 parent    8     18.1  19.60116 -1.50116 1.882     -0.79768
-#>   Dataset 8 parent   14     10.2  10.63101 -0.43101 1.882     -0.22903
-#>   Dataset 8 parent   14     10.8  10.63101  0.16899 1.882      0.08980
-#>   Dataset 8 parent   27      4.9   3.12435  1.77565 1.882      0.94354
-#>   Dataset 8 parent   27      3.3   3.12435  0.17565 1.882      0.09334
-#>   Dataset 8 parent   48      1.6   0.43578  1.16422 1.882      0.61864
-#>   Dataset 8 parent   48      1.5   0.43578  1.06422 1.882      0.56550
-#>   Dataset 8 parent   70      1.1   0.05534  1.04466 1.882      0.55510
-#>   Dataset 8 parent   70      0.9   0.05534  0.84466 1.882      0.44883
-#>   Dataset 8     A1    1      9.6   7.63450  1.96550 1.882      1.04442
-#>   Dataset 8     A1    1      7.7   7.63450  0.06550 1.882      0.03481
-#>   Dataset 8     A1    3     15.0  15.52593 -0.52593 1.882     -0.27947
-#>   Dataset 8     A1    3     15.1  15.52593 -0.42593 1.882     -0.22633
-#>   Dataset 8     A1    8     21.2  20.32192  0.87808 1.882      0.46659
-#>   Dataset 8     A1    8     21.1  20.32192  0.77808 1.882      0.41345
-#>   Dataset 8     A1   14     19.7  20.09721 -0.39721 1.882     -0.21107
-#>   Dataset 8     A1   14     18.9  20.09721 -1.19721 1.882     -0.63617
-#>   Dataset 8     A1   27     17.5  16.37477  1.12523 1.882      0.59792
-#>   Dataset 8     A1   27     15.9  16.37477 -0.47477 1.882     -0.25228
-#>   Dataset 8     A1   48      9.5  10.13141 -0.63141 1.882     -0.33551
-#>   Dataset 8     A1   48      9.8  10.13141 -0.33141 1.882     -0.17610
-#>   Dataset 8     A1   70      6.2   5.81827  0.38173 1.882      0.20284
-#>   Dataset 8     A1   70      6.1   5.81827  0.28173 1.882      0.14970
-#>   Dataset 9 parent    0     99.8  97.48728  2.31272 1.882      1.22892
-#>   Dataset 9 parent    0     98.3  97.48728  0.81272 1.882      0.43186
-#>   Dataset 9 parent    1     77.1  79.29476 -2.19476 1.882     -1.16624
-#>   Dataset 9 parent    1     77.2  79.29476 -2.09476 1.882     -1.11310
-#>   Dataset 9 parent    3     59.0  55.67060  3.32940 1.882      1.76915
-#>   Dataset 9 parent    3     58.1  55.67060  2.42940 1.882      1.29092
-#>   Dataset 9 parent    8     27.4  31.57871 -4.17871 1.882     -2.22046
-#>   Dataset 9 parent    8     29.2  31.57871 -2.37871 1.882     -1.26398
-#>   Dataset 9 parent   14     19.1  22.51546 -3.41546 1.882     -1.81489
-#>   Dataset 9 parent   14     29.6  22.51546  7.08454 1.882      3.76454
-#>   Dataset 9 parent   27     10.1  14.09074 -3.99074 1.882     -2.12057
-#>   Dataset 9 parent   27     18.2  14.09074  4.10926 1.882      2.18355
-#>   Dataset 9 parent   48      4.5   6.95747 -2.45747 1.882     -1.30584
-#>   Dataset 9 parent   48      9.1   6.95747  2.14253 1.882      1.13848
-#>   Dataset 9 parent   70      2.3   3.32472 -1.02472 1.882     -0.54451
-#>   Dataset 9 parent   70      2.9   3.32472 -0.42472 1.882     -0.22569
-#>   Dataset 9 parent   91      2.0   1.64300  0.35700 1.882      0.18970
-#>   Dataset 9 parent   91      1.8   1.64300  0.15700 1.882      0.08343
-#>   Dataset 9 parent  120      2.0   0.62073  1.37927 1.882      0.73291
-#>   Dataset 9 parent  120      2.2   0.62073  1.57927 1.882      0.83918
-#>   Dataset 9     A1    1      4.2   3.64568  0.55432 1.882      0.29455
-#>   Dataset 9     A1    1      3.9   3.64568  0.25432 1.882      0.13514
-#>   Dataset 9     A1    3      7.4   8.30173 -0.90173 1.882     -0.47916
-#>   Dataset 9     A1    3      7.9   8.30173 -0.40173 1.882     -0.21347
-#>   Dataset 9     A1    8     14.5  12.71589  1.78411 1.882      0.94803
-#>   Dataset 9     A1    8     13.7  12.71589  0.98411 1.882      0.52293
-#>   Dataset 9     A1   14     14.2  13.90452  0.29548 1.882      0.15701
-#>   Dataset 9     A1   14     12.2  13.90452 -1.70452 1.882     -0.90574
-#>   Dataset 9     A1   27     13.7  14.15523 -0.45523 1.882     -0.24190
-#>   Dataset 9     A1   27     13.2  14.15523 -0.95523 1.882     -0.50759
-#>   Dataset 9     A1   48     13.6  13.31038  0.28962 1.882      0.15389
-#>   Dataset 9     A1   48     15.4  13.31038  2.08962 1.882      1.11037
-#>   Dataset 9     A1   70     10.4  11.85965 -1.45965 1.882     -0.77562
-#>   Dataset 9     A1   70     11.6  11.85965 -0.25965 1.882     -0.13797
-#>   Dataset 9     A1   91     10.0  10.36294 -0.36294 1.882     -0.19286
-#>   Dataset 9     A1   91      9.5  10.36294 -0.86294 1.882     -0.45855
-#>   Dataset 9     A1  120      9.1   8.43003  0.66997 1.882      0.35601
-#>   Dataset 9     A1  120      9.0   8.43003  0.56997 1.882      0.30287
-#>  Dataset 10 parent    0     96.1  93.95603  2.14397 1.882      1.13925
-#>  Dataset 10 parent    0     94.3  93.95603  0.34397 1.882      0.18278
-#>  Dataset 10 parent    8     73.9  77.70592 -3.80592 1.882     -2.02237
-#>  Dataset 10 parent    8     73.9  77.70592 -3.80592 1.882     -2.02237
-#>  Dataset 10 parent   14     69.4  70.04570 -0.64570 1.882     -0.34311
-#>  Dataset 10 parent   14     73.1  70.04570  3.05430 1.882      1.62298
-#>  Dataset 10 parent   21     65.6  64.01710  1.58290 1.882      0.84111
-#>  Dataset 10 parent   21     65.3  64.01710  1.28290 1.882      0.68170
-#>  Dataset 10 parent   41     55.9  54.98434  0.91566 1.882      0.48656
-#>  Dataset 10 parent   41     54.4  54.98434 -0.58434 1.882     -0.31050
-#>  Dataset 10 parent   63     47.0  49.87137 -2.87137 1.882     -1.52577
-#>  Dataset 10 parent   63     49.3  49.87137 -0.57137 1.882     -0.30361
-#>  Dataset 10 parent   91     44.7  45.06727 -0.36727 1.882     -0.19516
-#>  Dataset 10 parent   91     46.7  45.06727  1.63273 1.882      0.86759
-#>  Dataset 10 parent  120     42.1  40.76402  1.33598 1.882      0.70991
-#>  Dataset 10 parent  120     41.3  40.76402  0.53598 1.882      0.28481
-#>  Dataset 10     A1    8      3.3   4.14599 -0.84599 1.882     -0.44954
-#>  Dataset 10     A1    8      3.4   4.14599 -0.74599 1.882     -0.39640
-#>  Dataset 10     A1   14      3.9   6.08478 -2.18478 1.882     -1.16093
-#>  Dataset 10     A1   14      2.9   6.08478 -3.18478 1.882     -1.69231
-#>  Dataset 10     A1   21      6.4   7.59411 -1.19411 1.882     -0.63452
-#>  Dataset 10     A1   21      7.2   7.59411 -0.39411 1.882     -0.20942
-#>  Dataset 10     A1   41      9.1   9.78292 -0.68292 1.882     -0.36289
-#>  Dataset 10     A1   41      8.5   9.78292 -1.28292 1.882     -0.68171
-#>  Dataset 10     A1   63     11.7  10.93274  0.76726 1.882      0.40770
-#>  Dataset 10     A1   63     12.0  10.93274  1.06726 1.882      0.56711
-#>  Dataset 10     A1   91     13.3  11.93986  1.36014 1.882      0.72274
-#>  Dataset 10     A1   91     13.2  11.93986  1.26014 1.882      0.66961
-#>  Dataset 10     A1  120     14.3  12.79238  1.50762 1.882      0.80111
-#>  Dataset 10     A1  120     12.1  12.79238 -0.69238 1.882     -0.36791
-
-# The following takes about 6 minutes
-f_saem_dfop_sfo_deSolve <- saem(f_mmkin["DFOP-SFO", ], solution_type = "deSolve",
-  nbiter.saemix = c(200, 80))
-#> DINTDY-  T (=R1) illegal      
-#> In above message, R1 = 70
-#>  
-#>       T not in interval TCUR - HU (= R1) to TCUR (=R2)      
-#> In above message, R1 = 53.1122, R2 = 56.6407
-#>  
-#> DINTDY-  T (=R1) illegal      
-#> In above message, R1 = 91
-#>  
-#>       T not in interval TCUR - HU (= R1) to TCUR (=R2)      
-#> In above message, R1 = 53.1122, R2 = 56.6407
-#>  
-#> DLSODA-  Trouble in DINTDY.  ITASK = I1, TOUT = R1
-#> In above message, I1 = 1
-#>  
-#> In above message, R1 = 91
-#>  
-#> Error in deSolve::lsoda(y = odeini, times = outtimes, func = lsoda_func,  : 
-#>   illegal input detected before taking any integration steps - see written message
-
-#anova(
-#  f_saem_dfop_sfo,
-#  f_saem_dfop_sfo_deSolve))
-
-# If the model supports it, we can also use eigenvalue based solutions, which
-# take a similar amount of time
-#f_saem_sfo_sfo_eigen <- saem(f_mmkin["SFO-SFO", ], solution_type = "eigen",
-#  control = list(nbiter.saemix = c(200, 80), nbdisplay = 10))
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/schaefer07_complex_case-1.png b/docs/dev/reference/schaefer07_complex_case-1.png deleted file mode 100644 index 7622ae7f..00000000 Binary files a/docs/dev/reference/schaefer07_complex_case-1.png and /dev/null differ diff --git a/docs/dev/reference/schaefer07_complex_case.html b/docs/dev/reference/schaefer07_complex_case.html deleted file mode 100644 index 880e5ac0..00000000 --- a/docs/dev/reference/schaefer07_complex_case.html +++ /dev/null @@ -1,221 +0,0 @@ - -Metabolism data set used for checking the software quality of KinGUI — schaefer07_complex_case • mkin - - -
-
- - - -
-
-
-

Metabolism data set used for checking the software quality of KinGUI

- - -
- -
-

This dataset was used for a comparison of KinGUI and ModelMaker to check the - software quality of KinGUI in the original publication (Schäfer et al., 2007). - The results from the fitting are also included.

-
- -
- 
schaefer07_complex_case
-
- -
-

Format

-

The data set is a data frame with 8 observations on the following 6 variables.

time
-

a numeric vector

- -
parent
-

a numeric vector

- -
A1
-

a numeric vector

- -
B1
-

a numeric vector

- -
C1
-

a numeric vector

- -
A2
-

a numeric vector

- - -

The results are a data frame with 14 results for different parameter values

-
-
-

References

-

Schäfer D, Mikolasch B, Rainbird P and Harvey B (2007). KinGUI: a new kinetic - software tool for evaluations according to FOCUS degradation kinetics. In: Del - Re AAM, Capri E, Fragoulis G and Trevisan M (Eds.). Proceedings of the XIII - Symposium Pesticide Chemistry, Piacenza, 2007, p. 916-923.

-
- -
-

Examples

- 
data <- mkin_wide_to_long(schaefer07_complex_case, time = "time")
-model <- mkinmod(
-  parent = list(type = "SFO", to = c("A1", "B1", "C1"), sink = FALSE),
-  A1 = list(type = "SFO", to = "A2"),
-  B1 = list(type = "SFO"),
-  C1 = list(type = "SFO"),
-  A2 = list(type = "SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-  # \dontrun{
-    fit <- mkinfit(model, data, quiet = TRUE)
-    plot(fit)
-
-    endpoints(fit)
-#> $ff
-#>   parent_A1   parent_B1   parent_C1 parent_sink       A1_A2     A1_sink 
-#>   0.3809620   0.1954667   0.4235713   0.0000000   0.4479619   0.5520381 
-#> 
-#> $distimes
-#>            DT50      DT90
-#> parent 13.95078  46.34350
-#> A1     49.75342 165.27728
-#> B1     37.26908 123.80520
-#> C1     11.23131  37.30961
-#> A2     28.50624  94.69567
-#> 
-  # }
- # Compare with the results obtained in the original publication
- print(schaefer07_complex_results)
-#>         compound          parameter  KinGUI ModelMaker deviation
-#> 1         parent   degradation rate  0.0496     0.0506       2.0
-#> 2         parent               DT50 13.9900    13.6900       2.2
-#> 3  metabolite A1 formation fraction  0.3803     0.3696       2.9
-#> 4  metabolite A1   degradation rate  0.0139     0.0136       2.2
-#> 5  metabolite A1               DT50 49.9600    50.8900       1.8
-#> 6  metabolite B1 formation fraction  0.1866     0.1818       2.6
-#> 7  metabolite B1   degradation rate  0.0175     0.0172       1.7
-#> 8  metabolite B1               DT50 39.6100    40.2400       1.6
-#> 9  metabolite C1 formation fraction  0.4331     0.4486       3.5
-#> 10 metabolite C1   degradation rate  0.0638     0.0700       8.9
-#> 11 metabolite C1               DT50 10.8700     9.9000       9.8
-#> 12 metabolite A2 formation fraction  0.4529     0.4559       0.7
-#> 13 metabolite A2   degradation rate  0.0245     0.0244       0.4
-#> 14 metabolite A2               DT50 28.2400    28.4500       0.7
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/set_nd_nq.html b/docs/dev/reference/set_nd_nq.html deleted file mode 100644 index 6f4ae169..00000000 --- a/docs/dev/reference/set_nd_nq.html +++ /dev/null @@ -1,278 +0,0 @@ - -Set non-detects and unquantified values in residue series without replicates — set_nd_nq • mkin - - -
-
- - - -
-
-
-

Set non-detects and unquantified values in residue series without replicates

- Source: R/set_nd_nq.R - -
- -
-

This function automates replacing unquantified values in residue time and -depth series. For time series, the function performs part of the residue -processing proposed in the FOCUS kinetics guidance for parent compounds -and metabolites. For two-dimensional residue series over time and depth, -it automates the proposal of Boesten et al (2015).

-
- -
- 
set_nd_nq(res_raw, lod, loq = NA, time_zero_presence = FALSE)
-
-set_nd_nq_focus(
-  res_raw,
-  lod,
-  loq = NA,
-  set_first_sample_nd = TRUE,
-  first_sample_nd_value = 0,
-  ignore_below_loq_after_first_nd = TRUE
-)
-
- -
-

Arguments

-
res_raw
-

Character vector of a residue time series, or matrix of -residue values with rows representing depth profiles for a specific sampling -time, and columns representing time series of residues at the same depth. -Values below the limit of detection (lod) have to be coded as "nd", values -between the limit of detection and the limit of quantification, if any, have -to be coded as "nq". Samples not analysed have to be coded as "na". All -values that are not "na", "nd" or "nq" have to be coercible to numeric

- - -
lod
-

Limit of detection (numeric)

- - -
loq
-

Limit of quantification(numeric). Must be specified if the FOCUS rule to -stop after the first non-detection is to be applied

- - -
time_zero_presence
-

Do we assume that residues occur at time zero? -This only affects samples from the first sampling time that have been -reported as "nd" (not detected).

- - -
set_first_sample_nd
-

Should the first sample be set to "first_sample_nd_value" -in case it is a non-detection?

- - -
first_sample_nd_value
-

Value to be used for the first sample if it is a non-detection

- - -
ignore_below_loq_after_first_nd
-

Should we ignore values below the LOQ after the first -non-detection that occurs after the quantified values?

- -
-
-

Value

- - -

A numeric vector, if a vector was supplied, or a numeric matrix otherwise

-
-
-

Functions

- -

  • set_nd_nq_focus(): Set non-detects in residue time series according to FOCUS rules

    • -
-
-

References

-

Boesten, J. J. T. I., van der Linden, A. M. A., Beltman, W. H. -J. and Pol, J. W. (2015). Leaching of plant protection products and their -transformation products; Proposals for improving the assessment of leaching -to groundwater in the Netherlands — Version 2. Alterra report 2630, Alterra -Wageningen UR (University & Research centre)

-

FOCUS (2014) Generic Guidance for Estimating Persistence and Degradation -Kinetics from Environmental Fate Studies on Pesticides in EU Registration, Version 1.1, -18 December 2014, p. 251

-
- -
-

Examples

- 
# FOCUS (2014) p. 75/76 and 131/132
-parent_1 <- c(.12, .09, .05, .03, "nd", "nd", "nd", "nd", "nd", "nd")
-set_nd_nq(parent_1, 0.02)
-#>  [1] 0.12 0.09 0.05 0.03 0.01   NA   NA   NA   NA   NA
-parent_2 <- c(.12, .09, .05, .03, "nd", "nd", .03, "nd", "nd", "nd")
-set_nd_nq(parent_2, 0.02)
-#>  [1] 0.12 0.09 0.05 0.03 0.01 0.01 0.03 0.01   NA   NA
-set_nd_nq_focus(parent_2, 0.02, loq = 0.05)
-#>  [1] 0.12 0.09 0.05 0.03 0.01   NA   NA   NA   NA   NA
-parent_3 <- c(.12, .09, .05, .03, "nd", "nd", .06, "nd", "nd", "nd")
-set_nd_nq(parent_3, 0.02)
-#>  [1] 0.12 0.09 0.05 0.03 0.01 0.01 0.06 0.01   NA   NA
-set_nd_nq_focus(parent_3, 0.02, loq = 0.05)
-#>  [1] 0.12 0.09 0.05 0.03 0.01 0.01 0.06 0.01   NA   NA
-metabolite <- c("nd", "nd", "nd", 0.03, 0.06, 0.10, 0.11, 0.10, 0.09, 0.05, 0.03, "nd", "nd")
-set_nd_nq(metabolite, 0.02)
-#>  [1]   NA   NA 0.01 0.03 0.06 0.10 0.11 0.10 0.09 0.05 0.03 0.01   NA
-set_nd_nq_focus(metabolite, 0.02, 0.05)
-#>  [1] 0.00   NA 0.01 0.03 0.06 0.10 0.11 0.10 0.09 0.05 0.03 0.01   NA
-#
-# Boesten et al. (2015), p. 57/58
-table_8 <- matrix(
-  c(10, 10, rep("nd", 4),
-    10, 10, rep("nq", 2), rep("nd", 2),
-    10, 10, 10, "nq", "nd", "nd",
-    "nq", 10, "nq", rep("nd", 3),
-    "nd", "nq", "nq", rep("nd", 3),
-    rep("nd", 6), rep("nd", 6)),
-  ncol = 6, byrow = TRUE)
-set_nd_nq(table_8, 0.5, 1.5, time_zero_presence = TRUE)
-#>       [,1]  [,2]  [,3] [,4] [,5] [,6]
-#> [1,] 10.00 10.00  0.25 0.25   NA   NA
-#> [2,] 10.00 10.00  1.00 1.00 0.25   NA
-#> [3,] 10.00 10.00 10.00 1.00 0.25   NA
-#> [4,]  1.00 10.00  1.00 0.25   NA   NA
-#> [5,]  0.25  1.00  1.00 0.25   NA   NA
-#> [6,]    NA  0.25  0.25   NA   NA   NA
-#> [7,]    NA    NA    NA   NA   NA   NA
-table_10 <- matrix(
-  c(10, 10, rep("nd", 4),
-    10, 10, rep("nd", 4),
-    10, 10, 10, rep("nd", 3),
-    "nd", 10, rep("nd", 4),
-    rep("nd", 18)),
-  ncol = 6, byrow = TRUE)
-set_nd_nq(table_10, 0.5, time_zero_presence = TRUE)
-#>       [,1]  [,2]  [,3] [,4] [,5] [,6]
-#> [1,] 10.00 10.00  0.25   NA   NA   NA
-#> [2,] 10.00 10.00  0.25   NA   NA   NA
-#> [3,] 10.00 10.00 10.00 0.25   NA   NA
-#> [4,]  0.25 10.00  0.25   NA   NA   NA
-#> [5,]    NA  0.25    NA   NA   NA   NA
-#> [6,]    NA    NA    NA   NA   NA   NA
-#> [7,]    NA    NA    NA   NA   NA   NA
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/sigma_twocomp-1.png b/docs/dev/reference/sigma_twocomp-1.png deleted file mode 100644 index 3671c658..00000000 Binary files a/docs/dev/reference/sigma_twocomp-1.png and /dev/null differ diff --git a/docs/dev/reference/sigma_twocomp.html b/docs/dev/reference/sigma_twocomp.html deleted file mode 100644 index 0ead0184..00000000 --- a/docs/dev/reference/sigma_twocomp.html +++ /dev/null @@ -1,216 +0,0 @@ - -Two-component error model — sigma_twocomp • mkin - - -
-
- - - -
-
-
-

Two-component error model

- Source: R/sigma_twocomp.R - -
- -
-

Function describing the standard deviation of the measurement error in -dependence of the measured value \(y\):

-
- -
- 
sigma_twocomp(y, sigma_low, rsd_high)
-
- -
-

Arguments

-
y
-

The magnitude of the observed value

- - -
sigma_low
-

The asymptotic minimum of the standard deviation for low -observed values

- - -
rsd_high
-

The coefficient describing the increase of the standard -deviation with the magnitude of the observed value

- -
-
-

Value

- - -

The standard deviation of the response variable.

-
-
-

Details

-

$$\sigma = \sqrt{ \sigma_{low}^2 + y^2 * {rsd}_{high}^2}$$ sigma = -sqrt(sigma_low^2 + y^2 * rsd_high^2)

-

This is the error model used for example by Werner et al. (1978). The model -proposed by Rocke and Lorenzato (1995) can be written in this form as well, -but assumes approximate lognormal distribution of errors for high values of -y.

-
-
-

References

-

Werner, Mario, Brooks, Samuel H., and Knott, Lancaster B. (1978) -Additive, Multiplicative, and Mixed Analytical Errors. Clinical Chemistry -24(11), 1895-1898.

-

Rocke, David M. and Lorenzato, Stefan (1995) A two-component model for -measurement error in analytical chemistry. Technometrics 37(2), 176-184.

-

Ranke J and Meinecke S (2019) Error Models for the Kinetic Evaluation of Chemical -Degradation Data. Environments 6(12) 124 -doi:10.3390/environments6120124 -.

-
- -
-

Examples

- 
times <- c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-d_pred <- data.frame(time = times, parent = 100 * exp(- 0.03 * times))
-set.seed(123456)
-d_syn <- add_err(d_pred, function(y) sigma_twocomp(y, 1, 0.07),
-  reps = 2, n = 1)[[1]]
-f_nls <- nls(value ~ SSasymp(time, 0, parent_0, lrc), data = d_syn,
- start = list(parent_0 = 100, lrc = -3))
-library(nlme)
-f_gnls <- gnls(value ~ SSasymp(time, 0, parent_0, lrc),
-  data = d_syn, na.action = na.omit,
-  start = list(parent_0 = 100, lrc = -3))
-if (length(findFunction("varConstProp")) > 0) {
-  f_gnls_tc <- update(f_gnls, weights = varConstProp())
-  f_gnls_tc_sf <- update(f_gnls_tc, control = list(sigma = 1))
-}
-f_mkin <- mkinfit("SFO", d_syn, error_model = "const", quiet = TRUE)
-f_mkin_tc <- mkinfit("SFO", d_syn, error_model = "tc", quiet = TRUE)
-plot_res(f_mkin_tc, standardized = TRUE)
-
-AIC(f_nls, f_gnls, f_gnls_tc, f_gnls_tc_sf, f_mkin, f_mkin_tc)
-#>              df      AIC
-#> f_nls         3 114.4817
-#> f_gnls        3 114.4817
-#> f_gnls_tc     5 103.6447
-#> f_gnls_tc_sf  4 101.6447
-#> f_mkin        3 114.4817
-#> f_mkin_tc     4 101.6446
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/status.html b/docs/dev/reference/status.html deleted file mode 100644 index df3e3a44..00000000 --- a/docs/dev/reference/status.html +++ /dev/null @@ -1,191 +0,0 @@ - -Method to get status information for fit array objects — status • mkin - - -
-
- - - -
-
-
-

Method to get status information for fit array objects

- Source: R/status.R - -
- -
-

Method to get status information for fit array objects

-
- -
- 
status(object, ...)
-
-# S3 method for mmkin
-status(object, ...)
-
-# S3 method for status.mmkin
-print(x, ...)
-
-# S3 method for mhmkin
-status(object, ...)
-
-# S3 method for status.mhmkin
-print(x, ...)
-
- -
-

Arguments

-
object
-

The object to investigate

- - -
...
-

For potential future extensions

- - -
x
-

The object to be printed

- -
-
-

Value

- - -

An object with the same dimensions as the fit array -suitable printing method.

-
- -
-

Examples

- 
# \dontrun{
-fits <- mmkin(
-  c("SFO", "FOMC"),
-  list("FOCUS A" = FOCUS_2006_A,
-       "FOCUS B" = FOCUS_2006_C),
-  quiet = TRUE)
-status(fits)
-#>       dataset
-#> model  FOCUS A FOCUS B
-#>   SFO  OK      OK     
-#>   FOMC OK      OK     
-#> 
-#> OK: No warnings
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/summary.mkinfit.html b/docs/dev/reference/summary.mkinfit.html deleted file mode 100644 index f627c2f6..00000000 --- a/docs/dev/reference/summary.mkinfit.html +++ /dev/null @@ -1,334 +0,0 @@ - -Summary method for class "mkinfit" — summary.mkinfit • mkin - - -
-
- - - -
-
-
-

Summary method for class "mkinfit"

- Source: R/summary.mkinfit.R - -
- -
-

Lists model equations, initial parameter values, optimised parameters with -some uncertainty statistics, the chi2 error levels calculated according to -FOCUS guidance (2006) as defined therein, formation fractions, DT50 values -and optionally the data, consisting of observed, predicted and residual -values.

-
- -
- 
# S3 method for mkinfit
-summary(object, data = TRUE, distimes = TRUE, alpha = 0.05, ...)
-
-# S3 method for summary.mkinfit
-print(x, digits = max(3, getOption("digits") - 3), ...)
-
- -
-

Arguments

-
object
-

an object of class mkinfit.

- - -
data
-

logical, indicating whether the data should be included in the -summary.

- - -
distimes
-

logical, indicating whether DT50 and DT90 values should be -included.

- - -
alpha
-

error level for confidence interval estimation from t -distribution

- - -
...
-

optional arguments passed to methods like print.

- - -
x
-

an object of class summary.mkinfit.

- - -
digits
-

Number of digits to use for printing

- -
-
-

Value

- - -

The summary function returns a list with components, among others

-
version, Rversion
-

The mkin and R versions used

- -
date.fit, date.summary
-

The dates where the fit and the summary were -produced

- -
diffs
-

The differential equations used in the model

- -
use_of_ff
-

Was maximum or minimum use made of formation fractions

- -
bpar
-

Optimised and backtransformed -parameters

- -
data
-

The data (see Description above).

- -
start
-

The starting values and bounds, if applicable, for optimised -parameters.

- -
fixed
-

The values of fixed parameters.

- -
errmin
-

The chi2 error levels for -each observed variable.

- -
bparms.ode
-

All backtransformed ODE -parameters, for use as starting parameters for related models.

- -
errparms
-

Error model parameters.

- -
ff
-

The estimated formation fractions derived from the fitted -model.

- -
distimes
-

The DT50 and DT90 values for each observed variable.

- -
SFORB
-

If applicable, eigenvalues and fractional eigenvector component -g of SFORB systems in the model.

- -

The print method is called for its side effect, i.e. printing the summary.

-
-
-

References

-

FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-  summary(mkinfit("SFO", FOCUS_2006_A, quiet = TRUE))
-#> mkin version used for fitting:    1.2.3 
-#> R version used for fitting:       4.2.3 
-#> Date of fit:     Sun Apr 16 08:34:39 2023 
-#> Date of summary: Sun Apr 16 08:34:39 2023 
-#> 
-#> Equations:
-#> d_parent/dt = - k_parent * parent
-#> 
-#> Model predictions using solution type analytical 
-#> 
-#> Fitted using 131 model solutions performed in 0.009 s
-#> 
-#> Error model: Constant variance 
-#> 
-#> Error model algorithm: OLS 
-#> 
-#> Starting values for parameters to be optimised:
-#>           value   type
-#> parent_0 101.24  state
-#> k_parent   0.10 deparm
-#> 
-#> Starting values for the transformed parameters actually optimised:
-#>                   value lower upper
-#> parent_0     101.240000  -Inf   Inf
-#> log_k_parent  -2.302585  -Inf   Inf
-#> 
-#> Fixed parameter values:
-#> None
-#> 
-#> Results:
-#> 
-#>        AIC     BIC    logLik
-#>   55.28197 55.5203 -24.64099
-#> 
-#> Optimised, transformed parameters with symmetric confidence intervals:
-#>              Estimate Std. Error  Lower   Upper
-#> parent_0      109.200    3.70400 99.630 118.700
-#> log_k_parent   -3.291    0.09176 -3.527  -3.055
-#> sigma           5.266    1.31600  1.882   8.649
-#> 
-#> Parameter correlation:
-#>               parent_0 log_k_parent     sigma
-#> parent_0     1.000e+00    5.428e-01 1.642e-07
-#> log_k_parent 5.428e-01    1.000e+00 2.507e-07
-#> sigma        1.642e-07    2.507e-07 1.000e+00
-#> 
-#> Backtransformed parameters:
-#> Confidence intervals for internally transformed parameters are asymmetric.
-#> t-test (unrealistically) based on the assumption of normal distribution
-#> for estimators of untransformed parameters.
-#>           Estimate t value    Pr(>t)   Lower     Upper
-#> parent_0 109.20000   29.47 4.218e-07 99.6300 118.70000
-#> k_parent   0.03722   10.90 5.650e-05  0.0294   0.04712
-#> sigma      5.26600    4.00 5.162e-03  1.8820   8.64900
-#> 
-#> FOCUS Chi2 error levels in percent:
-#>          err.min n.optim df
-#> All data   8.385       2  6
-#> parent     8.385       2  6
-#> 
-#> Estimated disappearance times:
-#>         DT50  DT90
-#> parent 18.62 61.87
-#> 
-#> Data:
-#>  time variable observed predicted residual
-#>     0   parent   101.24   109.153  -7.9132
-#>     3   parent    99.27    97.622   1.6484
-#>     7   parent    90.11    84.119   5.9913
-#>    14   parent    72.19    64.826   7.3641
-#>    30   parent    29.71    35.738  -6.0283
-#>    62   parent     5.98    10.862  -4.8818
-#>    90   parent     1.54     3.831  -2.2911
-#>   118   parent     0.39     1.351  -0.9613
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/summary.mmkin.html b/docs/dev/reference/summary.mmkin.html deleted file mode 100644 index c27f1634..00000000 --- a/docs/dev/reference/summary.mmkin.html +++ /dev/null @@ -1,196 +0,0 @@ - -Summary method for class "mmkin" — summary.mmkin • mkin - - -
-
- - - -
-
-
-

Summary method for class "mmkin"

- Source: R/summary.mmkin.R - -
- -
-

Shows status information on the mkinfit objects contained in the object -and gives an overview of ill-defined parameters calculated by illparms.

-
- -
- 
# S3 method for mmkin
-summary(object, conf.level = 0.95, ...)
-
-# S3 method for summary.mmkin
-print(x, digits = max(3, getOption("digits") - 3), ...)
-
- -
-

Arguments

-
object
-

an object of class mmkin

- - -
conf.level
-

confidence level for testing parameters

- - -
...
-

optional arguments passed to methods like print.

- - -
x
-

an object of class summary.mmkin.

- - -
digits
-

number of digits to use for printing

- -
- -
-

Examples

- 

-fits <- mmkin(
-  c("SFO", "FOMC"),
-  list("FOCUS A" = FOCUS_2006_A,
-       "FOCUS C" = FOCUS_2006_C),
-  quiet = TRUE, cores = 1)
-  summary(fits)
-#> Error model: Constant variance 
-#> Fitted in 0.509 s
-#> 
-#> Status:
-#>       dataset
-#> model  FOCUS A FOCUS C
-#>   SFO  OK      OK     
-#>   FOMC OK      OK     
-#> 
-#> OK: No warnings
-#> 
-#> Ill-defined parameters:
-#>       dataset
-#> model  FOCUS A                      FOCUS C
-#>   SFO                                      
-#>   FOMC parent_0, alpha, beta, sigma        
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/summary.nlme.mmkin.html b/docs/dev/reference/summary.nlme.mmkin.html deleted file mode 100644 index cb2c20bd..00000000 --- a/docs/dev/reference/summary.nlme.mmkin.html +++ /dev/null @@ -1,435 +0,0 @@ - -Summary method for class "nlme.mmkin" — summary.nlme.mmkin • mkin - - -
-
- - - -
-
-
-

Summary method for class "nlme.mmkin"

- Source: R/summary.nlme.mmkin.R - -
- -
-

Lists model equations, initial parameter values, optimised parameters -for fixed effects (population), random effects (deviations from the -population mean) and residual error model, as well as the resulting -endpoints such as formation fractions and DT50 values. Optionally -(default is FALSE), the data are listed in full.

-
- -
- 
# S3 method for nlme.mmkin
-summary(
-  object,
-  data = FALSE,
-  verbose = FALSE,
-  distimes = TRUE,
-  alpha = 0.05,
-  ...
-)
-
-# S3 method for summary.nlme.mmkin
-print(x, digits = max(3, getOption("digits") - 3), verbose = x$verbose, ...)
-
- -
-

Arguments

-
object
-

an object of class nlme.mmkin

- - -
data
-

logical, indicating whether the full data should be included in -the summary.

- - -
verbose
-

Should the summary be verbose?

- - -
distimes
-

logical, indicating whether DT50 and DT90 values should be -included.

- - -
alpha
-

error level for confidence interval estimation from the t -distribution

- - -
...
-

optional arguments passed to methods like print.

- - -
x
-

an object of class summary.nlme.mmkin

- - -
digits
-

Number of digits to use for printing

- -
-
-

Value

- - -

The summary function returns a list based on the nlme object -obtained in the fit, with at least the following additional components

-
nlmeversion, mkinversion, Rversion
-

The nlme, mkin and R versions used

- -
date.fit, date.summary
-

The dates where the fit and the summary were -produced

- -
diffs
-

The differential equations used in the degradation model

- -
use_of_ff
-

Was maximum or minimum use made of formation fractions

- -
data
-

The data

- -
confint_trans
-

Transformed parameters as used in the optimisation, with confidence intervals

- -
confint_back
-

Backtransformed parameters, with confidence intervals if available

- -
ff
-

The estimated formation fractions derived from the fitted -model.

- -
distimes
-

The DT50 and DT90 values for each observed variable.

- -
SFORB
-

If applicable, eigenvalues of SFORB components of the model.

- -

The print method is called for its side effect, i.e. printing the summary.

-
-
-

Author

-

Johannes Ranke for the mkin specific parts -José Pinheiro and Douglas Bates for the components inherited from nlme

-
- -
-

Examples

- 

-# Generate five datasets following SFO kinetics
-sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-dt50_sfo_in_pop <- 50
-k_in_pop <- log(2) / dt50_sfo_in_pop
-set.seed(1234)
-k_in <- rlnorm(5, log(k_in_pop), 0.5)
-SFO <- mkinmod(parent = mkinsub("SFO"))
-
-pred_sfo <- function(k) {
-  mkinpredict(SFO,
-    c(k_parent = k),
-    c(parent = 100),
-    sampling_times)
-}
-
-ds_sfo_mean <- lapply(k_in, pred_sfo)
-names(ds_sfo_mean) <- paste("ds", 1:5)
-
-set.seed(12345)
-ds_sfo_syn <- lapply(ds_sfo_mean, function(ds) {
-  add_err(ds,
-    sdfunc = function(value) sqrt(1^2 + value^2 * 0.07^2),
-    n = 1)[[1]]
-})
-
-# \dontrun{
-# Evaluate using mmkin and nlme
-library(nlme)
-f_mmkin <- mmkin("SFO", ds_sfo_syn, quiet = TRUE, error_model = "tc", cores = 1)
-#> Warning: Optimisation did not converge:
-#> iteration limit reached without convergence (10)
-f_nlme <- nlme(f_mmkin)
-summary(f_nlme, data = TRUE)
-#> nlme version used for fitting:      3.1.162 
-#> mkin version used for pre-fitting:  1.2.3 
-#> R version used for fitting:         4.2.3 
-#> Date of fit:     Sun Apr 16 08:34:41 2023 
-#> Date of summary: Sun Apr 16 08:34:41 2023 
-#> 
-#> Equations:
-#> d_parent/dt = - k_parent * parent
-#> 
-#> Data:
-#> 90 observations of 1 variable(s) grouped in 5 datasets
-#> 
-#> Model predictions using solution type analytical 
-#> 
-#> Fitted in 0.194 s using 4 iterations
-#> 
-#> Variance model: Two-component variance function 
-#> 
-#> Mean of starting values for individual parameters:
-#>     parent_0 log_k_parent 
-#>      101.569       -4.454 
-#> 
-#> Fixed degradation parameter values:
-#> None
-#> 
-#> Results:
-#> 
-#>     AIC   BIC logLik
-#>   584.5 599.5 -286.2
-#> 
-#> Optimised, transformed parameters with symmetric confidence intervals:
-#>               lower    est.   upper
-#> parent_0     99.371 101.592 103.814
-#> log_k_parent -4.973  -4.449  -3.926
-#> 
-#> Correlation: 
-#>              parnt_0
-#> log_k_parent 0.0507 
-#> 
-#> Random effects:
-#>  Formula: list(parent_0 ~ 1, log_k_parent ~ 1)
-#>  Level: ds
-#>  Structure: Diagonal
-#>         parent_0 log_k_parent Residual
-#> StdDev: 6.92e-05       0.5863        1
-#> 
-#> Variance function:
-#>  Structure: Constant plus proportion of variance covariate
-#>  Formula: ~fitted(.) 
-#>  Parameter estimates:
-#>        const         prop 
-#> 0.0001208154 0.0789968021 
-#> 
-#> Backtransformed parameters with asymmetric confidence intervals:
-#>              lower      est.     upper
-#> parent_0 99.370882 101.59243 103.81398
-#> k_parent  0.006923   0.01168   0.01972
-#> 
-#> Estimated disappearance times:
-#>         DT50  DT90
-#> parent 59.32 197.1
-#> 
-#> Data:
-#>    ds   name time observed predicted  residual    std standardized
-#>  ds 1 parent    0    104.1   101.592   2.50757 8.0255     0.312451
-#>  ds 1 parent    0    105.0   101.592   3.40757 8.0255     0.424594
-#>  ds 1 parent    1     98.5   100.796  -2.29571 7.9625    -0.288313
-#>  ds 1 parent    1     96.1   100.796  -4.69571 7.9625    -0.589725
-#>  ds 1 parent    3    101.9    99.221   2.67904 7.8381     0.341796
-#>  ds 1 parent    3     85.2    99.221 -14.02096 7.8381    -1.788812
-#>  ds 1 parent    7     99.1    96.145   2.95512 7.5951     0.389081
-#>  ds 1 parent    7     93.0    96.145  -3.14488 7.5951    -0.414065
-#>  ds 1 parent   14     88.1    90.989  -2.88944 7.1879    -0.401987
-#>  ds 1 parent   14     84.1    90.989  -6.88944 7.1879    -0.958480
-#>  ds 1 parent   28     80.2    81.493  -1.29305 6.4377    -0.200857
-#>  ds 1 parent   28     91.3    81.493   9.80695 6.4377     1.523364
-#>  ds 1 parent   60     65.1    63.344   1.75642 5.0039     0.351008
-#>  ds 1 parent   60     65.8    63.344   2.45642 5.0039     0.490898
-#>  ds 1 parent   90     47.8    50.018  -2.21764 3.9512    -0.561252
-#>  ds 1 parent   90     53.5    50.018   3.48236 3.9512     0.881335
-#>  ds 1 parent  120     37.6    39.495  -1.89515 3.1200    -0.607423
-#>  ds 1 parent  120     39.3    39.495  -0.19515 3.1200    -0.062549
-#>  ds 2 parent    0    107.9   101.592   6.30757 8.0255     0.785943
-#>  ds 2 parent    0    102.1   101.592   0.50757 8.0255     0.063245
-#>  ds 2 parent    1    103.8   100.058   3.74159 7.9043     0.473361
-#>  ds 2 parent    1    108.6   100.058   8.54159 7.9043     1.080626
-#>  ds 2 parent    3     91.0    97.060  -6.05952 7.6674    -0.790297
-#>  ds 2 parent    3     84.9    97.060 -12.15952 7.6674    -1.585874
-#>  ds 2 parent    7     79.3    91.329 -12.02867 7.2147    -1.667251
-#>  ds 2 parent    7    100.9    91.329   9.57133 7.2147     1.326647
-#>  ds 2 parent   14     77.3    82.102  -4.80185 6.4858    -0.740366
-#>  ds 2 parent   14     83.5    82.102   1.39815 6.4858     0.215571
-#>  ds 2 parent   28     66.8    66.351   0.44945 5.2415     0.085748
-#>  ds 2 parent   28     63.3    66.351  -3.05055 5.2415    -0.582002
-#>  ds 2 parent   60     40.8    40.775   0.02474 3.2211     0.007679
-#>  ds 2 parent   60     44.8    40.775   4.02474 3.2211     1.249485
-#>  ds 2 parent   90     27.8    25.832   1.96762 2.0407     0.964198
-#>  ds 2 parent   90     27.0    25.832   1.16762 2.0407     0.572171
-#>  ds 2 parent  120     15.2    16.366  -1.16561 1.2928    -0.901595
-#>  ds 2 parent  120     15.5    16.366  -0.86561 1.2928    -0.669547
-#>  ds 3 parent    0     97.7   101.592  -3.89243 8.0255    -0.485009
-#>  ds 3 parent    0     88.2   101.592 -13.39243 8.0255    -1.668739
-#>  ds 3 parent    1    109.9    99.218  10.68196 7.8379     1.362858
-#>  ds 3 parent    1     97.8    99.218  -1.41804 7.8379    -0.180921
-#>  ds 3 parent    3    100.5    94.634   5.86555 7.4758     0.784603
-#>  ds 3 parent    3     77.4    94.634 -17.23445 7.4758    -2.305360
-#>  ds 3 parent    7     78.3    86.093  -7.79273 6.8011    -1.145813
-#>  ds 3 parent    7     90.3    86.093   4.20727 6.8011     0.618620
-#>  ds 3 parent   14     76.0    72.958   3.04222 5.7634     0.527848
-#>  ds 3 parent   14     79.1    72.958   6.14222 5.7634     1.065722
-#>  ds 3 parent   28     46.0    52.394  -6.39404 4.1390    -1.544842
-#>  ds 3 parent   28     53.4    52.394   1.00596 4.1390     0.243046
-#>  ds 3 parent   60     25.1    24.582   0.51786 1.9419     0.266676
-#>  ds 3 parent   60     21.4    24.582  -3.18214 1.9419    -1.638664
-#>  ds 3 parent   90     11.0    12.092  -1.09202 0.9552    -1.143199
-#>  ds 3 parent   90     14.2    12.092   2.10798 0.9552     2.206776
-#>  ds 3 parent  120      5.8     5.948  -0.14810 0.4699    -0.315178
-#>  ds 3 parent  120      6.1     5.948   0.15190 0.4699     0.323282
-#>  ds 4 parent    0     95.3   101.592  -6.29243 8.0255    -0.784057
-#>  ds 4 parent    0    102.0   101.592   0.40757 8.0255     0.050784
-#>  ds 4 parent    1    104.4   101.125   3.27549 7.9885     0.410025
-#>  ds 4 parent    1    105.4   101.125   4.27549 7.9885     0.535205
-#>  ds 4 parent    3    113.7   100.195  13.50487 7.9151     1.706218
-#>  ds 4 parent    3     82.3   100.195 -17.89513 7.9151    -2.260886
-#>  ds 4 parent    7     98.1    98.362  -0.26190 7.7703    -0.033706
-#>  ds 4 parent    7     87.8    98.362 -10.56190 7.7703    -1.359270
-#>  ds 4 parent   14     97.9    95.234   2.66590 7.5232     0.354357
-#>  ds 4 parent   14    104.8    95.234   9.56590 7.5232     1.271521
-#>  ds 4 parent   28     85.0    89.274  -4.27372 7.0523    -0.606001
-#>  ds 4 parent   28     77.2    89.274 -12.07372 7.0523    -1.712017
-#>  ds 4 parent   60     82.2    77.013   5.18660 6.0838     0.852526
-#>  ds 4 parent   60     86.1    77.013   9.08660 6.0838     1.493571
-#>  ds 4 parent   90     70.5    67.053   3.44692 5.2970     0.650733
-#>  ds 4 parent   90     61.7    67.053  -5.35308 5.2970    -1.010591
-#>  ds 4 parent  120     60.0    58.381   1.61905 4.6119     0.351058
-#>  ds 4 parent  120     56.4    58.381  -1.98095 4.6119    -0.429530
-#>  ds 5 parent    0     92.6   101.592  -8.99243 8.0255    -1.120485
-#>  ds 5 parent    0    116.5   101.592  14.90757 8.0255     1.857531
-#>  ds 5 parent    1    108.0    99.914   8.08560 7.8929     1.024413
-#>  ds 5 parent    1    104.9    99.914   4.98560 7.8929     0.631655
-#>  ds 5 parent    3    100.5    96.641   3.85898 7.6343     0.505477
-#>  ds 5 parent    3     89.5    96.641  -7.14102 7.6343    -0.935383
-#>  ds 5 parent    7     91.7    90.412   1.28752 7.1423     0.180267
-#>  ds 5 parent    7     95.1    90.412   4.68752 7.1423     0.656304
-#>  ds 5 parent   14     82.2    80.463   1.73715 6.3563     0.273295
-#>  ds 5 parent   14     84.5    80.463   4.03715 6.3563     0.635141
-#>  ds 5 parent   28     60.5    63.728  -3.22788 5.0343    -0.641178
-#>  ds 5 parent   28     72.8    63.728   9.07212 5.0343     1.802062
-#>  ds 5 parent   60     38.3    37.399   0.90061 2.9544     0.304835
-#>  ds 5 parent   60     40.7    37.399   3.30061 2.9544     1.117174
-#>  ds 5 parent   90     22.5    22.692  -0.19165 1.7926    -0.106913
-#>  ds 5 parent   90     20.8    22.692  -1.89165 1.7926    -1.055273
-#>  ds 5 parent  120     13.4    13.768  -0.36790 1.0876    -0.338259
-#>  ds 5 parent  120     13.8    13.768   0.03210 1.0876     0.029517
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/summary.nlmixr.mmkin.html b/docs/dev/reference/summary.nlmixr.mmkin.html deleted file mode 100644 index 31f68f3f..00000000 --- a/docs/dev/reference/summary.nlmixr.mmkin.html +++ /dev/null @@ -1,2914 +0,0 @@ - -Summary method for class "nlmixr.mmkin" — summary.nlmixr.mmkin • mkin - - -
-
- - - -
-
-
-

Summary method for class "nlmixr.mmkin"

- Source: R/summary.nlmixr.mmkin.R - -
- -
-

Lists model equations, initial parameter values, optimised parameters -for fixed effects (population), random effects (deviations from the -population mean) and residual error model, as well as the resulting -endpoints such as formation fractions and DT50 values. Optionally -(default is FALSE), the data are listed in full.

-
- -
- 
# S3 method for nlmixr.mmkin
-summary(object, data = FALSE, verbose = FALSE, distimes = TRUE, ...)
-
-# S3 method for summary.nlmixr.mmkin
-print(x, digits = max(3, getOption("digits") - 3), verbose = x$verbose, ...)
-
- -
-

Arguments

-
object
-

an object of class nlmixr.mmkin

-
data
-

logical, indicating whether the full data should be included in -the summary.

-
verbose
-

Should the summary be verbose?

-
distimes
-

logical, indicating whether DT50 and DT90 values should be -included.

-
...
-

optional arguments passed to methods like print.

-
x
-

an object of class summary.nlmixr.mmkin

-
digits
-

Number of digits to use for printing

-
-
-

Value

-

The summary function returns a list obtained in the fit, with at -least the following additional components

-
nlmixrversion, mkinversion, Rversion
-

The nlmixr, mkin and R versions used

-
date.fit, date.summary
-

The dates where the fit and the summary were -produced

-
diffs
-

The differential equations used in the degradation model

-
use_of_ff
-

Was maximum or minimum use made of formation fractions

-
data
-

The data

-
confint_back
-

Backtransformed parameters, with confidence intervals if available

-
ff
-

The estimated formation fractions derived from the fitted -model.

-
distimes
-

The DT50 and DT90 values for each observed variable.

-
SFORB
-

If applicable, eigenvalues of SFORB components of the model.

-

The print method is called for its side effect, i.e. printing the summary.

-
-
-

Author

-

Johannes Ranke for the mkin specific parts -nlmixr authors for the parts inherited from nlmixr.

-
- -
-

Examples

- 
# Generate five datasets following DFOP-SFO kinetics
-sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-dfop_sfo <- mkinmod(parent = mkinsub("DFOP", "m1"),
- m1 = mkinsub("SFO"), quiet = TRUE)
-set.seed(1234)
-k1_in <- rlnorm(5, log(0.1), 0.3)
-k2_in <- rlnorm(5, log(0.02), 0.3)
-g_in <- plogis(rnorm(5, qlogis(0.5), 0.3))
-f_parent_to_m1_in <- plogis(rnorm(5, qlogis(0.3), 0.3))
-k_m1_in <- rlnorm(5, log(0.02), 0.3)
-
-pred_dfop_sfo <- function(k1, k2, g, f_parent_to_m1, k_m1) {
-  mkinpredict(dfop_sfo,
-    c(k1 = k1, k2 = k2, g = g, f_parent_to_m1 = f_parent_to_m1, k_m1 = k_m1),
-    c(parent = 100, m1 = 0),
-    sampling_times)
-}
-
-ds_mean_dfop_sfo <- lapply(1:5, function(i) {
-  mkinpredict(dfop_sfo,
-    c(k1 = k1_in[i], k2 = k2_in[i], g = g_in[i],
-      f_parent_to_m1 = f_parent_to_m1_in[i], k_m1 = k_m1_in[i]),
-    c(parent = 100, m1 = 0),
-    sampling_times)
-})
-names(ds_mean_dfop_sfo) <- paste("ds", 1:5)
-
-ds_syn_dfop_sfo <- lapply(ds_mean_dfop_sfo, function(ds) {
-  add_err(ds,
-    sdfunc = function(value) sqrt(1^2 + value^2 * 0.07^2),
-    n = 1)[[1]]
-})
-
-# \dontrun{
-# Evaluate using mmkin and nlmixr
-f_mmkin_dfop_sfo <- mmkin(list(dfop_sfo), ds_syn_dfop_sfo,
-  quiet = TRUE, error_model = "tc", cores = 5)
-f_saemix_dfop_sfo <- mkin::saem(f_mmkin_dfop_sfo)
-f_nlme_dfop_sfo <- mkin::nlme(f_mmkin_dfop_sfo)
-f_nlmixr_dfop_sfo_saem <- nlmixr(f_mmkin_dfop_sfo, est = "saem")
-#> With est = 'saem', a different error model is required for each observed variableChanging the error model to 'obs_tc' (Two-component error for each observed variable)
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#>  
-#> → generate SAEM model
-#> ✔ done
-#> 1:    99.5921   -3.9040   -2.1350   -3.7103   -2.0097    0.3217    6.6502    0.1520    0.5415    0.1995    0.3705    0.5588    7.9084    0.0824    7.5666    0.1777
-#> 2:    99.9835   -3.8650   -2.3586   -4.0306   -1.6536    0.0696    6.3177    0.1590    0.5144    0.1895    0.3520    0.5308    4.7746    0.0649    4.5667    0.0865
-#> 3:    1.0014e+02  -4.0173e+00  -2.3869e+00  -4.0840e+00  -1.2338e+00   3.4899e-02   6.0018e+00   1.5109e-01   4.8870e-01   1.8005e-01   3.3438e-01   5.0428e-01   2.8890e+00   7.0377e-02   2.9045e+00   9.5437e-02
-#> 4:    1.0024e+02  -4.1414e+00  -2.4972e+00  -4.1082e+00  -1.0291e+00  -1.0684e-02   5.7017e+00   1.4354e-01   4.6427e-01   1.7105e-01   3.1766e-01   4.7907e-01   2.1715e+00   8.9921e-02   1.8765e+00   1.0403e-01
-#> 5:    1.0068e+02  -4.1132e+00  -2.4776e+00  -4.0576e+00  -1.0391e+00  -8.8738e-02   5.8192e+00   1.3636e-01   4.4106e-01   1.6249e-01   3.0177e-01   4.5512e-01   1.6349e+00   8.3197e-02   1.4947e+00   1.0221e-01
-#> 6:    1.0044e+02  -4.0883e+00  -2.3931e+00  -4.1068e+00  -9.5058e-01  -1.2696e-01   5.5283e+00   1.2954e-01   4.1900e-01   1.5437e-01   2.8669e-01   4.5581e-01   1.4126e+00   8.1219e-02   1.2286e+00   1.0043e-01
-#> 7:    1.0103e+02  -4.0833e+00  -2.4194e+00  -4.0894e+00  -9.8547e-01   5.2360e-03   9.8755e+00   1.2306e-01   3.9805e-01   1.4665e-01   2.7235e-01   5.3394e-01   1.3620e+00   7.9842e-02   1.0649e+00   1.0298e-01
-#> 8:    1.0106e+02  -4.0535e+00  -2.3489e+00  -4.0682e+00  -9.4455e-01  -9.4310e-02   9.3818e+00   1.1691e-01   3.7815e-01   1.3932e-01   2.5873e-01   5.0724e-01   1.2163e+00   7.0820e-02   1.0147e+00   9.2362e-02
-#> 9:    1.0150e+02  -4.0498e+00  -2.4037e+00  -4.0719e+00  -9.3384e-01  -1.2384e-01   8.9127e+00   1.1107e-01   3.5924e-01   1.3235e-01   2.4580e-01   5.3463e-01   1.0849e+00   7.7513e-02   9.8295e-01   8.5927e-02
-#> 10:    1.0089e+02  -4.0313e+00  -2.3670e+00  -4.0573e+00  -9.0269e-01  -1.6427e-01   8.4670e+00   1.0551e-01   3.4128e-01   1.2573e-01   2.3351e-01   5.4980e-01   1.1274e+00   7.6000e-02   9.8582e-01   8.9740e-02
-#> 11:    1.0089e+02  -4.0664e+00  -2.3547e+00  -4.0554e+00  -9.3659e-01  -1.6900e-01   8.0437e+00   1.0024e-01   3.2422e-01   1.1945e-01   2.2183e-01   5.2231e-01   1.1513e+00   7.5801e-02   9.7638e-01   8.5324e-02
-#> 12:    1.0067e+02  -4.0427e+00  -2.3729e+00  -4.0413e+00  -9.2169e-01  -2.0927e-01   8.6156e+00   9.5225e-02   3.0801e-01   1.1348e-01   2.1074e-01   6.0288e-01   1.1918e+00   7.4830e-02   9.1899e-01   8.7983e-02
-#> 13:    1.0042e+02  -4.0387e+00  -2.3650e+00  -4.0623e+00  -9.3973e-01  -2.2277e-01   8.1848e+00   9.0463e-02   2.9260e-01   1.0780e-01   2.0020e-01   5.7274e-01   1.1022e+00   7.3652e-02   9.1657e-01   8.7973e-02
-#> 14:    1.0020e+02  -4.0227e+00  -2.3586e+00  -4.0333e+00  -9.4451e-01  -1.8020e-01   7.7756e+00   8.5940e-02   2.7797e-01   1.0241e-01   1.9019e-01   5.4410e-01   1.0728e+00   8.0169e-02   7.8974e-01   9.0162e-02
-#> 15:    1.0045e+02  -4.0209e+00  -2.3544e+00  -4.0187e+00  -8.9758e-01  -2.4348e-01   7.3868e+00   8.1643e-02   2.6408e-01   9.7291e-02   1.8068e-01   6.4534e-01   1.0287e+00   7.9387e-02   7.3357e-01   9.0858e-02
-#> 16:    1.0061e+02  -4.0195e+00  -2.3678e+00  -4.0419e+00  -8.9130e-01  -2.4248e-01   7.0175e+00   7.7561e-02   2.5087e-01   9.2427e-02   1.7165e-01   6.7145e-01   1.0440e+00   7.9292e-02   8.4681e-01   8.5285e-02
-#> 17:    1.0034e+02  -4.0298e+00  -2.3685e+00  -4.0637e+00  -8.9550e-01  -1.0712e-01   6.6666e+00   7.3683e-02   2.3833e-01   8.7805e-02   1.6307e-01   6.3788e-01   1.0827e+00   7.1441e-02   8.5278e-01   8.8090e-02
-#> 18:    99.8774   -4.0600   -2.3805   -4.0726   -0.9545   -0.1196    6.3333    0.0700    0.2264    0.0834    0.1549    0.6060    1.0056    0.0751    0.8017    0.0877
-#> 19:    1.0055e+02  -4.0731e+00  -2.2711e+00  -4.0824e+00  -9.5827e-01  -5.9764e-02   6.0166e+00   6.6499e-02   2.1509e-01   7.9244e-02   1.4717e-01   5.7835e-01   9.3185e-01   7.9396e-02   8.2332e-01   9.1277e-02
-#> 20:    1.0060e+02  -4.1023e+00  -2.2841e+00  -4.0757e+00  -9.7931e-01  -1.0440e-01   5.7158e+00   6.3174e-02   2.0434e-01   7.5282e-02   1.3981e-01   6.4675e-01   1.0006e+00   7.7840e-02   8.7958e-01   9.1512e-02
-#> 21:    1.0095e+02  -4.0955e+00  -2.3274e+00  -4.1038e+00  -9.5611e-01  -5.2481e-02   5.8063e+00   6.0015e-02   1.9412e-01   7.1518e-02   1.3282e-01   6.4943e-01   1.0926e+00   7.2665e-02   9.0450e-01   8.6278e-02
-#> 22:    1.0083e+02  -4.0789e+00  -2.3108e+00  -4.1074e+00  -9.6548e-01  -4.9665e-02   5.5160e+00   5.7014e-02   1.8441e-01   6.7942e-02   1.2618e-01   6.7304e-01   9.3297e-01   8.1042e-02   8.9206e-01   9.2336e-02
-#> 23:    1.0114e+02  -4.0924e+00  -2.4027e+00  -4.0947e+00  -9.7291e-01  -5.0773e-02   5.2567e+00   5.4164e-02   1.7519e-01   6.5747e-02   1.1987e-01   7.3402e-01   9.7858e-01   8.2133e-02   8.4928e-01   8.8254e-02
-#> 24:    1.0151e+02  -4.0787e+00  -2.3696e+00  -4.0712e+00  -9.5647e-01  -5.4136e-02   4.9938e+00   5.1456e-02   1.6643e-01   6.2460e-02   1.1388e-01   7.1847e-01   9.7548e-01   7.7691e-02   9.0418e-01   8.9115e-02
-#> 25:    1.0158e+02  -4.0830e+00  -2.3384e+00  -4.0705e+00  -9.5727e-01  -8.4974e-02   4.7442e+00   4.8883e-02   1.5811e-01   5.9337e-02   1.0818e-01   6.8255e-01   1.0340e+00   7.4497e-02   9.0691e-01   9.0886e-02
-#> 26:    1.0156e+02  -4.0784e+00  -2.3030e+00  -4.1027e+00  -9.5638e-01  -4.9456e-03   4.5069e+00   4.6439e-02   1.5021e-01   5.6370e-02   1.1189e-01   6.4842e-01   1.0537e+00   7.7612e-02   9.6725e-01   8.7824e-02
-#> 27:    1.0198e+02  -4.0828e+00  -2.3006e+00  -4.0803e+00  -9.9402e-01  -8.3280e-02   4.2816e+00   4.4117e-02   1.4270e-01   5.3552e-02   1.3300e-01   6.1600e-01   9.1051e-01   7.7677e-02   9.5949e-01   8.6552e-02
-#> 28:    1.0183e+02  -4.0871e+00  -2.2822e+00  -4.0596e+00  -9.9920e-01  -1.1469e-01   4.0675e+00   4.1911e-02   1.3556e-01   5.0874e-02   1.4021e-01   5.8520e-01   1.0294e+00   7.0917e-02   8.6440e-01   9.0301e-02
-#> 29:    1.0171e+02  -4.0838e+00  -2.2606e+00  -4.0885e+00  -9.8937e-01  -6.6488e-02   4.3393e+00   3.9815e-02   1.2878e-01   4.8330e-02   1.3320e-01   5.5594e-01   1.0042e+00   8.1585e-02   8.5434e-01   8.6032e-02
-#> 30:    1.0177e+02  -4.0861e+00  -2.2615e+00  -4.0670e+00  -9.9119e-01  -1.1322e-01   6.3058e+00   3.7825e-02   1.2942e-01   4.5914e-02   1.4223e-01   5.2814e-01   9.6301e-01   7.3336e-02   9.2366e-01   8.9276e-02
-#> 31:    1.0160e+02  -4.0900e+00  -2.2455e+00  -4.0514e+00  -9.8754e-01  -2.2617e-01   5.9905e+00   3.5933e-02   1.2295e-01   4.3618e-02   1.3512e-01   5.2898e-01   1.0441e+00   7.6262e-02   1.0227e+00   8.3759e-02
-#> 32:    1.0193e+02  -4.0967e+00  -2.2599e+00  -4.0295e+00  -9.8917e-01  -1.6626e-01   5.6910e+00   3.4137e-02   1.2620e-01   4.1437e-02   1.4303e-01   5.0253e-01   9.8083e-01   7.4136e-02   1.0031e+00   8.5124e-02
-#> 33:    1.0215e+02  -4.0713e+00  -2.2563e+00  -4.0313e+00  -9.7361e-01  -1.8246e-01   5.4065e+00   3.2430e-02   1.1989e-01   3.9365e-02   1.5371e-01   4.7741e-01   9.6935e-01   8.0491e-02   9.7610e-01   8.0590e-02
-#> 34:    1.0251e+02  -4.0707e+00  -2.2635e+00  -4.0387e+00  -9.2149e-01  -1.3452e-01   6.3940e+00   3.0808e-02   1.1389e-01   3.7397e-02   1.6720e-01   4.5354e-01   9.2449e-01   7.4355e-02   1.0505e+00   8.3049e-02
-#> 35:    1.0278e+02  -4.0579e+00  -2.2877e+00  -4.0289e+00  -9.6632e-01  -1.2910e-01   6.0743e+00   2.9268e-02   1.0820e-01   3.5527e-02   1.7242e-01   4.3086e-01   1.0129e+00   7.3224e-02   1.0035e+00   7.9411e-02
-#> 36:    1.0283e+02  -4.0771e+00  -2.2977e+00  -4.0108e+00  -9.5228e-01  -2.1781e-01   5.7706e+00   2.7805e-02   1.0279e-01   3.3751e-02   1.7034e-01   4.0932e-01   9.0249e-01   7.9917e-02   9.4562e-01   8.2391e-02
-#> 37:    1.0228e+02  -4.0442e+00  -2.3061e+00  -4.0150e+00  -9.5376e-01  -1.4873e-01   5.4821e+00   2.6414e-02   9.7651e-02   3.2063e-02   1.7772e-01   3.8885e-01   9.0446e-01   8.1418e-02   9.7276e-01   8.3331e-02
-#> 38:    1.0220e+02  -4.0454e+00  -2.3204e+00  -4.0207e+00  -9.3198e-01  -1.9324e-01   5.2080e+00   2.5094e-02   1.0946e-01   3.0460e-02   1.6883e-01   3.6941e-01   8.9159e-01   7.8645e-02   9.5848e-01   8.2734e-02
-#> 39:    1.0193e+02  -4.0306e+00  -2.2926e+00  -4.0131e+00  -9.3448e-01  -2.1869e-01   6.7005e+00   2.3839e-02   1.0399e-01   2.8937e-02   1.6039e-01   3.5571e-01   9.0078e-01   7.8982e-02   9.3495e-01   8.3462e-02
-#> 40:    1.0217e+02  -4.0463e+00  -2.2823e+00  -4.0209e+00  -9.2912e-01  -2.3580e-01   8.7857e+00   2.2647e-02   9.8789e-02   2.7490e-02   1.5418e-01   3.3792e-01   8.5126e-01   7.8849e-02   9.5510e-01   8.3011e-02
-#> 41:    1.0210e+02  -4.0564e+00  -2.2213e+00  -4.0041e+00  -9.4137e-01  -2.4103e-01   9.2761e+00   2.1515e-02   9.5179e-02   2.6116e-02   1.4795e-01   3.9870e-01   9.8312e-01   7.1947e-02   1.0015e+00   8.1407e-02
-#> 42:    1.0201e+02  -4.0204e+00  -2.2598e+00  -3.9984e+00  -9.4412e-01  -2.6838e-01   8.8123e+00   2.0439e-02   9.0420e-02   2.4810e-02   1.5013e-01   4.0334e-01   9.5583e-01   7.5617e-02   9.5131e-01   8.2343e-02
-#> 43:    1.0244e+02  -4.0107e+00  -2.2178e+00  -3.9923e+00  -9.4481e-01  -3.1831e-01   8.3717e+00   1.9417e-02   9.5791e-02   2.3569e-02   1.5440e-01   4.8194e-01   9.4582e-01   7.4374e-02   9.7798e-01   8.3391e-02
-#> 44:    1.0211e+02  -4.0193e+00  -2.2379e+00  -3.9784e+00  -9.2192e-01  -3.0224e-01   7.9531e+00   1.8446e-02   9.1002e-02   2.6623e-02   1.4668e-01   4.5785e-01   9.4162e-01   7.4503e-02   9.3229e-01   7.8428e-02
-#> 45:    1.0183e+02  -4.0198e+00  -2.2150e+00  -3.9966e+00  -9.6219e-01  -3.0236e-01   7.5554e+00   1.7524e-02   8.6452e-02   2.8045e-02   1.4346e-01   4.3495e-01   9.3318e-01   7.5937e-02   9.4917e-01   8.2946e-02
-#> 46:    1.0132e+02  -4.0245e+00  -2.2215e+00  -3.9954e+00  -9.4368e-01  -2.6878e-01   7.1777e+00   1.6648e-02   9.5839e-02   2.6909e-02   1.4633e-01   4.1321e-01   9.7698e-01   7.1947e-02   9.6599e-01   8.3812e-02
-#> 47:    1.0138e+02  -4.0076e+00  -2.2741e+00  -4.0047e+00  -9.0608e-01  -2.2839e-01   6.8188e+00   1.5815e-02   9.2192e-02   2.5563e-02   1.6160e-01   3.9255e-01   9.3678e-01   7.4216e-02   1.0295e+00   7.9396e-02
-#> 48:    1.0102e+02  -4.0235e+00  -2.2764e+00  -4.0123e+00  -9.1050e-01  -2.0555e-01   6.4778e+00   1.5024e-02   8.7583e-02   2.4285e-02   1.6368e-01   3.7292e-01   9.2204e-01   7.6976e-02   1.0289e+00   8.1381e-02
-#> 49:    1.0074e+02  -4.0407e+00  -2.2583e+00  -4.0142e+00  -9.2682e-01  -2.5941e-01   6.1540e+00   1.4273e-02   8.3203e-02   2.3071e-02   1.8251e-01   3.5427e-01   9.0436e-01   7.4192e-02   1.0237e+00   8.2178e-02
-#> 50:    1.0046e+02  -4.0626e+00  -2.2464e+00  -4.0201e+00  -9.3021e-01  -2.6983e-01   5.8463e+00   1.4303e-02   7.9043e-02   2.3395e-02   1.7339e-01   3.3846e-01   9.1334e-01   7.8046e-02   9.5881e-01   8.1223e-02
-#> 51:    1.0022e+02  -4.0414e+00  -2.2373e+00  -4.0107e+00  -9.2183e-01  -2.6371e-01   5.8667e+00   1.8681e-02   7.5091e-02   2.2225e-02   1.6472e-01   3.7327e-01   9.4906e-01   8.0171e-02   1.0278e+00   8.7157e-02
-#> 52:    1.0059e+02  -4.0444e+00  -2.2676e+00  -4.0263e+00  -9.1269e-01  -2.1748e-01   5.5734e+00   1.7747e-02   7.1337e-02   2.1114e-02   1.5648e-01   3.5461e-01   8.6417e-01   8.2918e-02   1.0332e+00   8.1690e-02
-#> 53:    1.0071e+02  -4.0384e+00  -2.2530e+00  -4.0171e+00  -9.2997e-01  -2.5319e-01   5.2947e+00   1.6860e-02   6.7770e-02   2.0058e-02   1.6621e-01   3.3688e-01   8.9792e-01   7.8990e-02   1.0230e+00   7.9862e-02
-#> 54:    1.0067e+02  -4.0271e+00  -2.2540e+00  -4.0251e+00  -9.2151e-01  -2.2197e-01   5.0300e+00   1.6017e-02   6.4381e-02   1.9055e-02   1.7025e-01   3.2003e-01   8.7999e-01   8.0187e-02   1.0487e+00   8.1091e-02
-#> 55:    1.0083e+02  -4.0326e+00  -2.2090e+00  -4.0230e+00  -9.2078e-01  -2.4936e-01   4.8429e+00   1.5216e-02   6.1162e-02   1.8103e-02   1.7211e-01   3.0403e-01   8.8923e-01   8.2248e-02   1.0522e+00   8.0777e-02
-#> 56:    1.0082e+02  -4.0284e+00  -2.2350e+00  -4.0083e+00  -8.9532e-01  -1.9565e-01   5.3306e+00   1.4455e-02   5.8104e-02   1.7197e-02   1.6350e-01   2.8883e-01   8.7438e-01   7.9530e-02   1.0748e+00   7.9892e-02
-#> 57:    1.0089e+02  -4.0118e+00  -2.2585e+00  -3.9924e+00  -9.5279e-01  -2.7691e-01   5.4228e+00   1.3733e-02   5.5199e-02   1.6338e-02   1.9088e-01   2.7439e-01   9.3164e-01   8.0286e-02   1.1149e+00   8.3224e-02
-#> 58:    1.0103e+02  -4.0117e+00  -2.2470e+00  -3.9628e+00  -9.5632e-01  -3.1385e-01   5.1517e+00   1.3046e-02   6.2482e-02   1.5521e-02   1.8744e-01   2.8144e-01   9.6857e-01   8.0586e-02   1.0149e+00   8.0615e-02
-#> 59:    1.0110e+02  -4.0400e+00  -2.2319e+00  -3.9749e+00  -9.3280e-01  -3.1491e-01   4.8941e+00   1.4375e-02   7.6521e-02   1.9982e-02   1.8994e-01   2.6736e-01   9.9294e-01   7.6723e-02   9.8321e-01   8.4135e-02
-#> 60:    1.0135e+02  -4.0401e+00  -2.2969e+00  -4.0006e+00  -9.3649e-01  -2.7105e-01   4.6494e+00   1.5352e-02   7.2695e-02   1.8983e-02   1.8339e-01   2.5400e-01   9.7671e-01   8.0731e-02   1.0344e+00   8.4798e-02
-#> 61:    1.0139e+02  -4.0447e+00  -2.3267e+00  -4.0036e+00  -9.2609e-01  -2.4279e-01   4.4169e+00   1.4584e-02   6.9060e-02   1.8034e-02   1.7844e-01   2.4130e-01   9.4921e-01   8.1065e-02   1.0031e+00   8.2364e-02
-#> 62:    1.0187e+02  -4.0605e+00  -2.2435e+00  -4.0093e+00  -9.4594e-01  -2.2911e-01   4.1961e+00   1.3855e-02   6.5607e-02   2.0229e-02   1.6951e-01   2.2923e-01   8.5507e-01   8.5043e-02   1.0003e+00   8.4881e-02
-#> 63:    1.0181e+02  -4.0665e+00  -2.2106e+00  -3.9954e+00  -9.5259e-01  -2.2539e-01   3.9863e+00   1.3162e-02   6.2327e-02   1.9217e-02   2.0722e-01   2.1777e-01   9.2699e-01   7.9303e-02   9.8900e-01   8.5477e-02
-#> 64:    1.0178e+02  -4.0641e+00  -2.2152e+00  -3.9904e+00  -9.7044e-01  -2.2671e-01   3.8289e+00   1.2504e-02   5.9210e-02   1.8256e-02   2.1010e-01   2.0688e-01   8.6741e-01   8.9748e-02   9.9564e-01   8.6675e-02
-#> 65:    1.0149e+02  -4.0871e+00  -2.2063e+00  -4.0000e+00  -9.7253e-01  -2.0360e-01   3.6375e+00   1.1879e-02   5.8060e-02   1.7344e-02   2.3758e-01   1.9654e-01   9.1092e-01   8.6259e-02   1.0674e+00   8.6171e-02
-#> 66:    1.0131e+02  -4.0863e+00  -2.2283e+00  -4.0026e+00  -9.6884e-01  -2.2153e-01   3.4556e+00   1.1285e-02   5.5157e-02   1.6476e-02   2.5128e-01   1.8671e-01   9.2512e-01   7.7687e-02   1.0847e+00   8.2689e-02
-#> 67:    1.0124e+02  -4.0691e+00  -2.2261e+00  -4.0021e+00  -9.2647e-01  -2.9309e-01   3.2828e+00   1.0721e-02   5.2400e-02   1.5653e-02   2.3872e-01   1.7738e-01   8.3514e-01   8.7680e-02   1.0093e+00   8.1515e-02
-#> 68:    1.0160e+02  -4.0653e+00  -2.2627e+00  -3.9685e+00  -9.5325e-01  -2.9870e-01   3.1187e+00   1.0185e-02   5.0455e-02   1.6013e-02   2.2678e-01   1.6851e-01   9.3016e-01   8.4873e-02   1.0357e+00   8.0066e-02
-#> 69:    1.0154e+02  -4.0667e+00  -2.2536e+00  -3.9686e+00  -9.8329e-01  -2.1749e-01   2.9628e+00   9.6753e-03   4.7932e-02   1.6408e-02   2.1544e-01   1.6008e-01   9.4932e-01   8.5396e-02   1.0298e+00   8.2915e-02
-#> 70:    1.0140e+02  -4.0718e+00  -2.2809e+00  -4.0031e+00  -9.7818e-01  -1.5912e-01   2.8146e+00   1.2376e-02   4.5536e-02   1.5606e-02   2.0467e-01   1.5208e-01   9.8171e-01   8.4966e-02   1.0881e+00   8.4583e-02
-#> 71:    1.0119e+02  -4.0810e+00  -2.2832e+00  -3.9945e+00  -9.7859e-01  -1.6288e-01   2.6739e+00   1.1757e-02   4.3259e-02   2.2477e-02   1.9444e-01   1.4447e-01   9.2355e-01   8.4027e-02   1.0557e+00   8.3942e-02
-#> 72:    1.0133e+02  -4.0904e+00  -2.2582e+00  -4.0034e+00  -1.0103e+00  -1.9818e-01   2.5402e+00   1.1169e-02   6.0710e-02   2.4943e-02   1.8472e-01   1.3725e-01   8.8530e-01   8.8313e-02   9.6043e-01   8.6565e-02
-#> 73:    1.0081e+02  -4.0852e+00  -2.2408e+00  -4.0324e+00  -9.8147e-01  -2.0245e-01   2.4132e+00   1.0611e-02   6.0672e-02   2.3696e-02   1.7586e-01   1.5058e-01   9.8632e-01   8.0072e-02   1.0754e+00   8.4211e-02
-#> 74:    1.0096e+02  -4.0784e+00  -2.2415e+00  -4.0085e+00  -9.6374e-01  -2.1820e-01   2.2925e+00   1.0080e-02   7.8175e-02   2.2511e-02   2.0451e-01   1.4305e-01   9.7218e-01   7.5856e-02   1.0703e+00   8.2684e-02
-#> 75:    1.0059e+02  -4.0614e+00  -2.2571e+00  -4.0069e+00  -9.6858e-01  -2.2415e-01   2.1779e+00   9.5763e-03   7.4266e-02   2.1385e-02   2.0050e-01   1.3590e-01   9.4625e-01   8.3873e-02   1.0545e+00   8.0628e-02
-#> 76:    1.0071e+02  -4.0570e+00  -2.2509e+00  -4.0111e+00  -9.4159e-01  -2.0936e-01   2.0690e+00   9.0975e-03   1.0546e-01   2.0316e-02   1.9048e-01   1.2911e-01   9.1139e-01   8.4290e-02   1.0164e+00   8.0587e-02
-#> 77:    1.0056e+02  -4.0315e+00  -2.2434e+00  -4.0068e+00  -9.1913e-01  -2.0655e-01   1.9656e+00   8.6426e-03   1.2867e-01   1.9300e-02   1.8971e-01   1.5112e-01   9.1748e-01   8.0221e-02   1.0080e+00   8.2126e-02
-#> 78:    1.0054e+02  -4.0350e+00  -2.2335e+00  -4.0109e+00  -9.4315e-01  -1.7472e-01   2.6310e+00   8.2105e-03   1.3206e-01   1.8867e-02   2.0835e-01   1.8443e-01   9.7893e-01   7.9595e-02   1.0622e+00   8.3669e-02
-#> 79:    1.0036e+02  -4.0500e+00  -2.2739e+00  -4.0223e+00  -9.6070e-01  -1.8756e-01   2.5665e+00   7.7999e-03   1.2546e-01   1.7924e-02   1.9794e-01   2.0106e-01   9.4360e-01   8.0070e-02   1.0209e+00   8.4807e-02
-#> 80:    1.0030e+02  -4.0522e+00  -2.2890e+00  -4.0149e+00  -9.2615e-01  -2.1233e-01   2.4382e+00   7.4099e-03   1.2570e-01   1.7028e-02   1.8804e-01   2.4730e-01   9.6559e-01   8.0105e-02   1.0382e+00   7.9028e-02
-#> 81:    1.0004e+02  -4.0462e+00  -2.2766e+00  -4.0158e+00  -9.0841e-01  -2.3731e-01   3.0663e+00   7.0394e-03   1.2300e-01   1.6176e-02   1.7864e-01   2.3493e-01   8.8273e-01   8.0620e-02   1.0835e+00   7.9915e-02
-#> 82:    1.0015e+02  -4.0106e+00  -2.2696e+00  -3.9845e+00  -9.2535e-01  -2.7387e-01   2.9130e+00   6.6875e-03   1.5058e-01   1.5368e-02   1.6971e-01   2.4826e-01   1.0039e+00   7.8035e-02   1.1181e+00   8.5136e-02
-#> 83:    1.0019e+02  -4.0111e+00  -2.2266e+00  -3.9884e+00  -8.8579e-01  -2.3822e-01   2.7674e+00   6.3531e-03   1.9061e-01   1.4599e-02   1.6122e-01   2.3585e-01   1.0256e+00   8.1065e-02   1.0988e+00   8.4111e-02
-#> 84:    99.9333   -4.0014   -2.2848   -3.9877   -0.8906   -0.2014    2.6290    0.0060    0.2388    0.0139    0.1532    0.2628    0.9936    0.0809    1.1059    0.0847
-#> 85:    99.6658   -4.0093   -2.2848   -3.9884   -0.8922   -0.2517    2.4976    0.0057    0.2269    0.0132    0.1455    0.2920    0.9705    0.0823    1.0458    0.0834
-#> 86:    99.8823   -4.0064   -2.2659   -4.0038   -0.9174   -0.1848    2.3727    0.0054    0.2155    0.0125    0.1382    0.2774    0.9699    0.0796    0.9808    0.0839
-#> 87:    1.0051e+02  -4.0156e+00  -2.2877e+00  -4.0160e+00  -8.9867e-01  -1.3463e-01   2.3477e+00   6.2688e-03   2.0474e-01   1.1891e-02   1.4859e-01   2.6352e-01   9.0742e-01   7.8361e-02   1.0082e+00   8.1020e-02
-#> 88:    1.0036e+02  -4.0013e+00  -2.2738e+00  -4.0184e+00  -9.1589e-01  -1.4154e-01   3.0581e+00   7.7930e-03   2.5551e-01   1.1297e-02   1.4116e-01   2.5035e-01   9.8581e-01   7.6769e-02   9.7255e-01   8.8653e-02
-#> 89:    1.0031e+02  -4.0155e+00  -2.3418e+00  -4.0080e+00  -8.8958e-01  -1.4006e-01   3.3754e+00   7.4891e-03   2.4274e-01   1.2919e-02   1.3411e-01   2.3783e-01   8.9921e-01   8.3685e-02   9.2657e-01   8.1804e-02
-#> 90:    1.0044e+02  -4.0279e+00  -2.3328e+00  -4.0081e+00  -9.1868e-01  -1.3077e-01   3.6776e+00   1.1221e-02   2.3380e-01   1.2419e-02   1.4247e-01   2.2594e-01   8.8620e-01   8.0520e-02   9.0269e-01   8.2413e-02
-#> 91:    1.0007e+02  -4.0329e+00  -2.3865e+00  -4.0145e+00  -8.9566e-01  -1.2400e-01   3.7450e+00   1.0660e-02   2.2211e-01   1.3667e-02   1.3534e-01   2.1539e-01   9.5638e-01   8.0235e-02   9.4346e-01   8.5828e-02
-#> 92:    1.0025e+02  -4.0506e+00  -2.3252e+00  -4.0445e+00  -9.2023e-01  -5.6654e-02   3.9282e+00   1.0127e-02   2.4912e-01   1.2984e-02   1.4349e-01   2.6955e-01   9.6021e-01   7.7975e-02   9.1878e-01   8.6695e-02
-#> 93:    1.0091e+02  -4.0566e+00  -2.2760e+00  -4.0422e+00  -9.2960e-01  -5.8179e-02   3.7318e+00   9.6210e-03   2.6385e-01   1.3422e-02   1.5136e-01   2.5607e-01   9.7012e-01   7.7323e-02   1.0157e+00   8.6123e-02
-#> 94:    1.0045e+02  -4.0682e+00  -2.3163e+00  -4.0391e+00  -9.3398e-01  -1.0367e-01   4.0009e+00   9.1399e-03   2.5066e-01   1.2751e-02   1.6029e-01   2.9867e-01   9.1442e-01   8.0048e-02   9.7607e-01   8.5436e-02
-#> 95:    1.0029e+02  -4.0790e+00  -2.2791e+00  -4.0470e+00  -9.4031e-01  -7.2610e-02   3.8008e+00   8.6829e-03   2.3813e-01   1.2114e-02   1.5227e-01   2.8373e-01   8.9105e-01   8.2168e-02   9.5542e-01   8.5308e-02
-#> 96:    1.0017e+02  -4.0818e+00  -2.3204e+00  -4.0507e+00  -9.2181e-01  -7.5195e-02   3.6108e+00   8.2488e-03   2.2622e-01   1.1508e-02   1.5273e-01   2.6955e-01   9.3179e-01   7.7026e-02   1.0092e+00   8.4966e-02
-#> 97:    1.0007e+02  -4.0721e+00  -2.3606e+00  -4.0453e+00  -9.4375e-01  -7.2811e-02   3.4303e+00   1.0904e-02   2.1585e-01   1.2641e-02   1.8282e-01   2.5788e-01   9.3750e-01   8.0427e-02   9.3193e-01   8.3262e-02
-#> 98:    1.0024e+02  -4.1025e+00  -2.3916e+00  -4.0401e+00  -9.6711e-01  -6.7764e-02   3.2587e+00   1.0359e-02   2.0506e-01   1.8712e-02   1.9260e-01   2.4499e-01   1.0086e+00   7.7282e-02   9.6010e-01   8.1760e-02
-#> 99:    1.0024e+02  -4.0755e+00  -2.3237e+00  -4.0581e+00  -9.5543e-01  -8.1716e-02   3.0958e+00   9.8408e-03   1.9481e-01   1.7973e-02   1.8297e-01   2.5653e-01   8.6589e-01   7.7940e-02   9.2919e-01   8.4396e-02
-#> 100:    1.0039e+02  -4.0828e+00  -2.2976e+00  -4.0616e+00  -9.8223e-01  -8.5593e-02   3.9873e+00   9.3488e-03   1.8507e-01   1.8837e-02   1.7382e-01   2.4370e-01   8.6471e-01   8.4021e-02   9.4587e-01   8.1697e-02
-#> 101:    1.0089e+02  -4.0738e+00  -2.3406e+00  -4.0465e+00  -9.4824e-01  -4.4055e-02   5.2624e+00   8.8814e-03   1.8051e-01   1.7896e-02   1.6513e-01   2.3288e-01   8.4179e-01   8.2487e-02   8.8097e-01   8.1625e-02
-#> 102:    1.0090e+02  -4.0777e+00  -2.3244e+00  -4.0500e+00  -9.4069e-01  -5.2554e-02   5.5339e+00   8.4373e-03   1.7148e-01   1.7001e-02   1.5688e-01   2.2124e-01   9.0419e-01   7.8446e-02   9.4721e-01   8.0896e-02
-#> 103:    1.0067e+02  -4.0658e+00  -2.3188e+00  -4.0312e+00  -9.5981e-01  -7.3735e-02   7.0281e+00   8.0154e-03   1.6291e-01   1.6151e-02   1.7019e-01   2.1018e-01   9.3631e-01   8.1516e-02   9.8773e-01   8.0587e-02
-#> 104:    1.0015e+02  -4.0729e+00  -2.3830e+00  -4.0458e+00  -9.4446e-01  -5.0075e-02   6.6767e+00   7.6147e-03   1.5476e-01   1.5343e-02   1.6822e-01   1.9967e-01   8.2373e-01   8.3029e-02   9.6909e-01   7.9505e-02
-#> 105:    1.0022e+02  -4.0888e+00  -2.3301e+00  -4.0411e+00  -9.5279e-01  -1.1412e-01   6.3429e+00   7.2339e-03   1.4702e-01   1.4576e-02   1.8886e-01   2.2088e-01   9.2925e-01   7.3020e-02   1.0450e+00   8.6511e-02
-#> 106:    1.0013e+02  -4.0846e+00  -2.3428e+00  -4.0530e+00  -9.1649e-01  -8.1899e-02   6.0257e+00   6.8722e-03   1.3967e-01   1.8939e-02   1.8350e-01   2.1970e-01   9.4571e-01   8.6259e-02   8.8509e-01   8.1023e-02
-#> 107:    1.0026e+02  -4.0954e+00  -2.3362e+00  -4.0586e+00  -9.6302e-01  -8.0898e-03   5.7244e+00   6.5286e-03   1.3269e-01   2.2595e-02   2.0043e-01   2.4151e-01   8.8882e-01   8.8155e-02   8.2466e-01   8.5467e-02
-#> 108:    1.0109e+02  -4.0796e+00  -2.3980e+00  -4.0841e+00  -9.5525e-01   2.0583e-02   5.4382e+00   6.2022e-03   1.2606e-01   3.4423e-02   2.2509e-01   2.3732e-01   9.0211e-01   8.1331e-02   9.2728e-01   8.4409e-02
-#> 109:    1.0091e+02  -4.0872e+00  -2.3614e+00  -4.0620e+00  -9.5950e-01  -1.8283e-02   5.1663e+00   6.1750e-03   1.1975e-01   3.2702e-02   2.1384e-01   2.2546e-01   9.7296e-01   7.7298e-02   9.7366e-01   8.3784e-02
-#> 110:    1.0137e+02  -4.0637e+00  -2.3734e+00  -4.0781e+00  -9.3874e-01  -6.0140e-03   4.9080e+00   6.5148e-03   1.1376e-01   3.1066e-02   2.0314e-01   2.3943e-01   9.2451e-01   8.4473e-02   9.7311e-01   8.4958e-02
-#> 111:    1.0181e+02  -4.0588e+00  -2.3200e+00  -4.0792e+00  -9.9395e-01  -3.1776e-02   4.6626e+00   9.9112e-03   1.0808e-01   4.1755e-02   1.9299e-01   2.9896e-01   1.0697e+00   7.1561e-02   1.0062e+00   8.8034e-02
-#> 112:    1.0222e+02  -4.0566e+00  -2.3525e+00  -4.0607e+00  -9.6055e-01  -6.3691e-02   4.4850e+00   9.4157e-03   1.0267e-01   4.0540e-02   1.8334e-01   3.5699e-01   1.0213e+00   7.5944e-02   1.0070e+00   8.3434e-02
-#> 113:    1.0189e+02  -4.0478e+00  -2.3774e+00  -4.0434e+00  -9.6638e-01  -6.7729e-02   5.1753e+00   8.9449e-03   9.7539e-02   3.8513e-02   2.0339e-01   3.4044e-01   9.5484e-01   7.7854e-02   9.8545e-01   8.1852e-02
-#> 114:    1.0225e+02  -4.0334e+00  -2.3728e+00  -4.0502e+00  -9.4795e-01  -7.3569e-02   4.9165e+00   8.8152e-03   9.2662e-02   3.7310e-02   2.0002e-01   3.2342e-01   9.3586e-01   8.1063e-02   9.5652e-01   8.3067e-02
-#> 115:    1.0196e+02  -4.0302e+00  -2.3599e+00  -4.0812e+00  -9.6783e-01   7.1536e-03   4.8473e+00   9.4780e-03   1.0791e-01   3.7184e-02   1.9002e-01   3.0725e-01   9.1488e-01   7.6079e-02   1.0104e+00   8.7136e-02
-#> 116:    1.0150e+02  -4.0420e+00  -2.3637e+00  -4.0535e+00  -9.4545e-01  -7.6387e-02   4.6049e+00   9.6408e-03   1.0251e-01   3.8115e-02   1.8052e-01   2.9189e-01   9.0583e-01   8.2597e-02   9.5680e-01   8.1246e-02
-#> 117:    1.0161e+02  -4.0606e+00  -2.3853e+00  -4.0750e+00  -9.7273e-01  -2.7338e-03   4.3747e+00   9.1587e-03   9.7386e-02   3.7863e-02   1.8701e-01   2.7729e-01   8.4511e-01   8.4164e-02   9.4149e-01   8.0525e-02
-#> 118:    1.0174e+02  -4.0727e+00  -2.3776e+00  -4.0850e+00  -9.6982e-01  -1.2188e-03   4.1560e+00   8.7008e-03   9.2516e-02   4.9300e-02   2.1364e-01   2.6343e-01   9.5447e-01   8.6627e-02   9.1835e-01   8.1284e-02
-#> 119:    1.0141e+02  -4.0887e+00  -2.3138e+00  -4.0772e+00  -9.9409e-01  -5.0120e-02   3.9482e+00   8.2658e-03   8.7891e-02   4.6835e-02   2.5364e-01   2.5026e-01   9.4576e-01   8.4355e-02   9.5762e-01   8.5430e-02
-#> 120:    1.0116e+02  -4.1014e+00  -2.3328e+00  -4.0418e+00  -9.7139e-01  -8.9664e-02   3.7508e+00   7.8525e-03   8.3496e-02   4.4493e-02   2.4096e-01   2.3774e-01   9.2816e-01   8.5558e-02   9.7817e-01   8.5169e-02
-#> 121:    1.0099e+02  -4.0876e+00  -2.3277e+00  -4.0746e+00  -9.5453e-01  -2.6752e-02   3.5632e+00   7.4598e-03   7.9321e-02   4.2269e-02   2.2891e-01   2.2586e-01   8.9613e-01   8.0488e-02   9.7590e-01   8.4798e-02
-#> 122:    1.0171e+02  -4.0620e+00  -2.3349e+00  -4.0659e+00  -9.4420e-01  -1.6907e-02   3.3851e+00   7.0869e-03   8.8424e-02   4.0155e-02   2.1747e-01   2.1456e-01   9.0159e-01   7.8017e-02   9.8579e-01   8.4585e-02
-#> 123:    1.0191e+02  -4.0708e+00  -2.3487e+00  -4.0827e+00  -9.5025e-01  -5.7459e-03   3.2158e+00   6.7325e-03   1.0499e-01   3.8147e-02   2.0659e-01   2.0384e-01   9.6378e-01   7.4758e-02   9.6268e-01   8.4712e-02
-#> 124:    1.0224e+02  -4.0798e+00  -2.2989e+00  -4.0724e+00  -9.8452e-01  -3.1802e-02   3.0550e+00   6.3959e-03   9.9739e-02   3.6240e-02   1.9626e-01   1.9364e-01   9.4424e-01   7.4219e-02   9.9842e-01   8.4793e-02
-#> 125:    1.0242e+02  -4.0710e+00  -2.3242e+00  -4.0661e+00  -1.0094e+00  -2.9970e-02   2.9023e+00   6.0761e-03   9.4752e-02   3.6130e-02   1.8645e-01   1.8396e-01   9.2576e-01   8.0533e-02   9.9407e-01   8.1660e-02
-#> 126:    1.0254e+02  -4.0685e+00  -2.3356e+00  -4.0599e+00  -1.0031e+00   4.0250e-03   2.7571e+00   5.7723e-03   1.0658e-01   3.4324e-02   1.7971e-01   1.7476e-01   9.4870e-01   7.4027e-02   9.2757e-01   8.3091e-02
-#> 127:    1.0270e+02  -4.0492e+00  -2.3174e+00  -4.0476e+00  -9.9898e-01  -6.3197e-02   2.6193e+00   5.4837e-03   1.0746e-01   3.2607e-02   1.7072e-01   1.6603e-01   9.0721e-01   7.7941e-02   9.4624e-01   8.1077e-02
-#> 128:    1.0284e+02  -4.0582e+00  -2.2991e+00  -4.0331e+00  -9.9114e-01  -5.6800e-02   2.4883e+00   5.2095e-03   1.2321e-01   3.1304e-02   1.6219e-01   1.5772e-01   8.7403e-01   8.4147e-02   8.9187e-01   8.5089e-02
-#> 129:    1.0275e+02  -4.0773e+00  -2.2935e+00  -4.0389e+00  -9.9661e-01  -7.4747e-02   2.3639e+00   4.9922e-03   1.1705e-01   2.9738e-02   1.9667e-01   1.4984e-01   9.1481e-01   8.4947e-02   9.3224e-01   8.5270e-02
-#> 130:    1.0222e+02  -4.0835e+00  -2.3177e+00  -4.0343e+00  -1.0044e+00  -7.6530e-02   2.2457e+00   4.7426e-03   1.1120e-01   3.1348e-02   2.0663e-01   1.4235e-01   1.0173e+00   7.4769e-02   9.9905e-01   8.6058e-02
-#> 131:    1.0202e+02  -4.0767e+00  -2.2497e+00  -4.0270e+00  -1.0015e+00  -1.4868e-01   2.1334e+00   5.5790e-03   1.0564e-01   2.9781e-02   2.1254e-01   1.3523e-01   1.0223e+00   7.7587e-02   9.4151e-01   8.4206e-02
-#> 132:    1.0191e+02  -4.0756e+00  -2.2363e+00  -4.0081e+00  -9.7264e-01  -2.0991e-01   2.0268e+00   5.3000e-03   1.0184e-01   2.8291e-02   2.0191e-01   1.7667e-01   9.2404e-01   7.9813e-02   9.2266e-01   8.6307e-02
-#> 133:    1.0187e+02  -4.0743e+00  -2.1951e+00  -4.0196e+00  -9.7534e-01  -1.8742e-01   1.9254e+00   5.0350e-03   9.6744e-02   2.6877e-02   1.9181e-01   1.6784e-01   1.0007e+00   8.2043e-02   1.0028e+00   8.3921e-02
-#> 134:    1.0182e+02  -4.0731e+00  -2.2321e+00  -4.0041e+00  -9.2800e-01  -1.4985e-01   1.8291e+00   4.7833e-03   9.1906e-02   2.7751e-02   1.8222e-01   1.6415e-01   9.7093e-01   7.5558e-02   9.8455e-01   8.4921e-02
-#> 135:    1.0188e+02  -4.0724e+00  -2.2774e+00  -4.0213e+00  -9.3930e-01  -1.7385e-01   1.7377e+00   4.5441e-03   8.7311e-02   2.6363e-02   1.7311e-01   1.5594e-01   9.4053e-01   8.3922e-02   9.8689e-01   8.1203e-02
-#> 136:    1.0202e+02  -4.0712e+00  -2.2711e+00  -4.0128e+00  -9.8747e-01  -1.3610e-01   1.6508e+00   4.3169e-03   1.0383e-01   2.5045e-02   1.8004e-01   1.4814e-01   9.6497e-01   8.1397e-02   1.0782e+00   8.2539e-02
-#> 137:    1.0228e+02  -4.0676e+00  -2.2403e+00  -4.0069e+00  -9.7761e-01  -1.5314e-01   1.5683e+00   4.1011e-03   1.0931e-01   2.4722e-02   1.8328e-01   1.4074e-01   9.8300e-01   7.5906e-02   1.0221e+00   8.2306e-02
-#> 138:    1.0229e+02  -4.0654e+00  -2.2510e+00  -3.9908e+00  -1.0400e+00  -1.4173e-01   1.4899e+00   4.2166e-03   1.3448e-01   2.3486e-02   1.8272e-01   1.3370e-01   1.0305e+00   8.0580e-02   1.0988e+00   8.3512e-02
-#> 139:    1.0258e+02  -4.0599e+00  -2.2207e+00  -3.9622e+00  -1.0058e+00  -2.6676e-01   1.4154e+00   4.0057e-03   1.5190e-01   2.2312e-02   1.7359e-01   1.2702e-01   9.6425e-01   8.6887e-02   1.0373e+00   8.3853e-02
-#> 140:    1.0224e+02  -4.0665e+00  -2.2479e+00  -4.0063e+00  -1.0054e+00  -1.6109e-01   1.3446e+00   3.8054e-03   1.4430e-01   2.4389e-02   1.6697e-01   1.2066e-01   9.9245e-01   8.3900e-02   1.1218e+00   8.2527e-02
-#> 141:    1.0245e+02  -4.0843e+00  -2.2024e+00  -3.9657e+00  -1.0057e+00  -2.4900e-01   1.2774e+00   3.6152e-03   1.3709e-01   2.3170e-02   1.8559e-01   1.1463e-01   9.4091e-01   8.7616e-02   1.0760e+00   8.1871e-02
-#> 142:    1.0253e+02  -4.0972e+00  -2.1943e+00  -3.9649e+00  -1.0160e+00  -2.9535e-01   1.2135e+00   3.4344e-03   1.6892e-01   2.2011e-02   1.7631e-01   1.0890e-01   9.2146e-01   9.0207e-02   1.0645e+00   8.5078e-02
-#> 143:    1.0252e+02  -4.1005e+00  -2.1652e+00  -3.9687e+00  -1.0445e+00  -2.4274e-01   2.0559e+00   3.9136e-03   1.6047e-01   2.0911e-02   1.6750e-01   1.0345e-01   9.0785e-01   8.5522e-02   1.1734e+00   8.5544e-02
-#> 144:    1.0257e+02  -4.1199e+00  -2.1994e+00  -3.9618e+00  -1.0480e+00  -2.0099e-01   1.9531e+00   4.2739e-03   1.5745e-01   1.9865e-02   1.6053e-01   9.8282e-02   9.3710e-01   8.5496e-02   1.0597e+00   8.4335e-02
-#> 145:    1.0282e+02  -4.1356e+00  -2.1489e+00  -3.9708e+00  -1.0268e+00  -2.2250e-01   1.8554e+00   4.0602e-03   1.7177e-01   1.8872e-02   1.5251e-01   9.3368e-02   9.5312e-01   8.3609e-02   1.0695e+00   8.3492e-02
-#> 146:    1.0282e+02  -4.1443e+00  -2.2103e+00  -3.9821e+00  -1.0080e+00  -2.2414e-01   1.7627e+00   4.0693e-03   1.6460e-01   1.7928e-02   1.5576e-01   8.8699e-02   9.8656e-01   8.4549e-02   1.0251e+00   7.9572e-02
-#> 147:    1.0295e+02  -4.1363e+00  -2.1920e+00  -3.9828e+00  -1.0567e+00  -1.9047e-01   1.6745e+00   3.8659e-03   1.6104e-01   1.7032e-02   1.6551e-01   8.4264e-02   9.4144e-01   8.7085e-02   1.0623e+00   8.1949e-02
-#> 148:    1.0299e+02  -4.1336e+00  -2.1967e+00  -3.9921e+00  -1.0425e+00  -1.7466e-01   1.7992e+00   3.6726e-03   1.5298e-01   1.9937e-02   1.9453e-01   8.0051e-02   9.9498e-01   8.3001e-02   1.0884e+00   8.1599e-02
-#> 149:    1.0292e+02  -4.1282e+00  -2.2741e+00  -4.0028e+00  -1.0650e+00  -1.4879e-01   2.1425e+00   3.4890e-03   1.4534e-01   1.8941e-02   2.0240e-01   7.6049e-02   1.0080e+00   7.9550e-02   1.1679e+00   7.9115e-02
-#> 150:    1.0302e+02  -4.1402e+00  -2.2769e+00  -4.0056e+00  -1.0488e+00  -1.2845e-01   2.7814e+00   3.3145e-03   1.3807e-01   2.0220e-02   1.9228e-01   7.2246e-02   9.9253e-01   8.0215e-02   1.0075e+00   8.2295e-02
-#> 151:    1.0304e+02  -4.1281e+00  -2.2250e+00  -4.0169e+00  -1.0448e+00  -1.4468e-01   2.6423e+00   3.1488e-03   1.3117e-01   2.1298e-02   1.8267e-01   6.8634e-02   1.0207e+00   8.0317e-02   1.0813e+00   8.5492e-02
-#> 152:    1.0321e+02  -4.1291e+00  -2.2281e+00  -4.0180e+00  -1.0232e+00  -1.4990e-01   1.6327e+00   2.8585e-03   1.0498e-01   1.8944e-02   1.6146e-01   5.0784e-02   9.5663e-01   7.9113e-02   1.1344e+00   8.2687e-02
-#> 153:    1.0309e+02  -4.1280e+00  -2.2030e+00  -4.0149e+00  -1.0198e+00  -1.3442e-01   1.6757e+00   3.4142e-03   9.0693e-02   2.2471e-02   1.6167e-01   3.6279e-02   9.6659e-01   8.1655e-02   1.0345e+00   8.6113e-02
-#> 154:    1.0298e+02  -4.1506e+00  -2.2176e+00  -3.9851e+00  -1.0417e+00  -1.6429e-01   1.9656e+00   3.3408e-03   9.5697e-02   2.1721e-02   1.6754e-01   2.9142e-02   1.0379e+00   7.9957e-02   1.0132e+00   8.5327e-02
-#> 155:    1.0328e+02  -4.1204e+00  -2.2287e+00  -3.9772e+00  -1.0135e+00  -2.0459e-01   1.9195e+00   3.3987e-03   1.0293e-01   1.6897e-02   1.9470e-01   2.0826e-02   9.4310e-01   8.0528e-02   1.0639e+00   8.1926e-02
-#> 156:    1.0338e+02  -4.1272e+00  -2.1962e+00  -3.9743e+00  -1.0491e+00  -1.8971e-01   1.7194e+00   3.2287e-03   7.8468e-02   1.8220e-02   1.8015e-01   2.0956e-02   9.2992e-01   8.6295e-02   9.5939e-01   8.1945e-02
-#> 157:    1.0331e+02  -4.1188e+00  -2.1783e+00  -3.9779e+00  -1.0506e+00  -1.9810e-01   1.1127e+00   2.7176e-03   6.1234e-02   1.3748e-02   2.0147e-01   3.4800e-02   9.3006e-01   8.4794e-02   1.0579e+00   8.1604e-02
-#> 158:    1.0326e+02  -4.1162e+00  -2.1734e+00  -3.9827e+00  -1.0632e+00  -2.0171e-01   1.3289e+00   2.7407e-03   7.1465e-02   1.2306e-02   2.1511e-01   3.4923e-02   8.9200e-01   8.4554e-02   1.1179e+00   8.2301e-02
-#> 159:    1.0358e+02  -4.1075e+00  -2.2069e+00  -3.9725e+00  -1.0445e+00  -1.8044e-01   1.6656e+00   2.5282e-03   6.4340e-02   1.3587e-02   2.0355e-01   2.7629e-02   8.9557e-01   8.3727e-02   1.0560e+00   8.0934e-02
-#> 160:    1.0364e+02  -4.1182e+00  -2.1514e+00  -3.9750e+00  -1.0378e+00  -2.2449e-01   1.8413e+00   3.5609e-03   7.2072e-02   1.5648e-02   2.0999e-01   3.1283e-02   9.1468e-01   8.2340e-02   1.0016e+00   8.0955e-02
-#> 161:    1.0387e+02  -4.0964e+00  -2.1926e+00  -3.9808e+00  -1.0397e+00  -2.5178e-01   2.3706e+00   2.4158e-03   7.4658e-02   1.7789e-02   1.8587e-01   3.1647e-02   8.8257e-01   8.4503e-02   9.5909e-01   8.2216e-02
-#> 162:    1.0399e+02  -4.0992e+00  -2.2056e+00  -3.9647e+00  -1.0388e+00  -2.4824e-01   1.9736e+00   2.2302e-03   1.0445e-01   1.9729e-02   1.9531e-01   2.9879e-02   8.3560e-01   8.6622e-02   9.5407e-01   7.9625e-02
-#> 163:    1.0366e+02  -4.0956e+00  -2.1684e+00  -3.9612e+00  -1.0058e+00  -2.6882e-01   2.5872e+00   1.6246e-03   8.1892e-02   2.2777e-02   2.2429e-01   2.8371e-02   8.4799e-01   9.0947e-02   9.5842e-01   8.2649e-02
-#> 164:    1.0325e+02  -4.0878e+00  -2.1946e+00  -3.9781e+00  -9.8890e-01  -2.6917e-01   2.0805e+00   1.3401e-03   8.2477e-02   2.6550e-02   1.8386e-01   2.4255e-02   8.5728e-01   8.9778e-02   9.1439e-01   7.9784e-02
-#> 165:    1.0282e+02  -4.0801e+00  -2.1928e+00  -3.9664e+00  -9.9558e-01  -2.6059e-01   1.4087e+00   1.2155e-03   5.8081e-02   2.3833e-02   2.1871e-01   2.0911e-02   8.6998e-01   8.9895e-02   9.9363e-01   8.0284e-02
-#> 166:    1.0285e+02  -4.0942e+00  -2.1855e+00  -3.9889e+00  -1.0234e+00  -2.4125e-01   8.5034e-01   6.8919e-04   6.5725e-02   2.3045e-02   2.1221e-01   2.6083e-02   8.7024e-01   9.4598e-02   9.5824e-01   8.3361e-02
-#> 167:    1.0267e+02  -4.0904e+00  -2.2131e+00  -3.9917e+00  -9.9055e-01  -2.1449e-01   9.1382e-01   4.6145e-04   8.1337e-02   2.2154e-02   2.1431e-01   2.7524e-02   8.4730e-01   8.3563e-02   9.9458e-01   8.0138e-02
-#> 168:    1.0249e+02  -4.0954e+00  -2.2174e+00  -3.9868e+00  -9.9799e-01  -1.8848e-01   6.5737e-01   4.2757e-04   6.9428e-02   2.8833e-02   2.0256e-01   4.1573e-02   9.8269e-01   7.6264e-02   1.0011e+00   8.1357e-02
-#> 169:    1.0252e+02  -4.0995e+00  -2.2132e+00  -3.9792e+00  -9.8661e-01  -2.2724e-01   5.4553e-01   3.9691e-04   4.2460e-02   2.7545e-02   2.2594e-01   4.9079e-02   9.6027e-01   8.1006e-02   1.0261e+00   8.5194e-02
-#> 170:    1.0246e+02  -4.1056e+00  -2.2389e+00  -3.9785e+00  -1.0354e+00  -2.4212e-01   4.5653e-01   2.8583e-04   2.8936e-02   2.5026e-02   1.8496e-01   4.3514e-02   9.2689e-01   9.6050e-02   9.9096e-01   8.3466e-02
-#> 171:    1.0238e+02  -4.1027e+00  -2.2592e+00  -3.9859e+00  -1.0106e+00  -2.3962e-01   5.1080e-01   2.6715e-04   3.2138e-02   2.7859e-02   1.6505e-01   6.2560e-02   9.1886e-01   9.0993e-02   9.4634e-01   8.3542e-02
-#> 172:    1.0242e+02  -4.0998e+00  -2.2415e+00  -3.9999e+00  -1.0234e+00  -2.2610e-01   5.1154e-01   1.8668e-04   2.2768e-02   2.9930e-02   2.0056e-01   7.5570e-02   9.4948e-01   8.4742e-02   9.1357e-01   8.3596e-02
-#> 173:    1.0232e+02  -4.1005e+00  -2.2382e+00  -4.0022e+00  -1.0017e+00  -1.8406e-01   3.2169e-01   2.0484e-04   2.4102e-02   2.9249e-02   2.0445e-01   1.1517e-01   9.5169e-01   8.3951e-02   9.0402e-01   8.3130e-02
-#> 174:    1.0233e+02  -4.0990e+00  -2.2337e+00  -3.9975e+00  -1.0298e+00  -1.8028e-01   4.2668e-01   2.1409e-04   2.4350e-02   2.4159e-02   2.0114e-01   1.4344e-01   9.3446e-01   8.6704e-02   9.6511e-01   8.3994e-02
-#> 175:    1.0236e+02  -4.0991e+00  -2.2315e+00  -3.9883e+00  -1.0110e+00  -2.2190e-01   4.1564e-01   2.5844e-04   3.5664e-02   2.1844e-02   2.0315e-01   1.2876e-01   8.9006e-01   8.3016e-02   9.2369e-01   8.0410e-02
-#> 176:    1.0222e+02  -4.0983e+00  -2.1991e+00  -3.9924e+00  -1.0148e+00  -2.3133e-01   1.7684e-01   2.5312e-04   5.3516e-02   2.2568e-02   2.0010e-01   1.0721e-01   8.9884e-01   7.6042e-02   1.0110e+00   7.9890e-02
-#> 177:    1.0219e+02  -4.1022e+00  -2.2129e+00  -3.9804e+00  -1.0286e+00  -1.9916e-01   1.9962e-01   3.0338e-04   6.9476e-02   2.0133e-02   1.8707e-01   1.0631e-01   8.7419e-01   8.3199e-02   9.5450e-01   8.2626e-02
-#> 178:    1.0225e+02  -4.1022e+00  -2.2135e+00  -4.0057e+00  -1.0264e+00  -2.2859e-01   2.1742e-01   2.9489e-04   5.1238e-02   2.2227e-02   1.7924e-01   1.4496e-01   8.5487e-01   8.3885e-02   9.7315e-01   8.1406e-02
-#> 179:    1.0234e+02  -4.1015e+00  -2.2170e+00  -3.9999e+00  -1.0177e+00  -2.0895e-01   2.1196e-01   3.0802e-04   5.7417e-02   2.6776e-02   1.7214e-01   1.5197e-01   8.8641e-01   7.7789e-02   9.2725e-01   8.1277e-02
-#> 180:    1.0243e+02  -4.1034e+00  -2.2337e+00  -4.0000e+00  -1.0018e+00  -2.3492e-01   2.0521e-01   3.1261e-04   6.0162e-02   2.7277e-02   1.7524e-01   1.6673e-01   8.8472e-01   7.8939e-02   9.1311e-01   8.3794e-02
-#> 181:    1.0244e+02  -4.1031e+00  -2.2415e+00  -3.9951e+00  -9.9356e-01  -1.9938e-01   1.4850e-01   2.7894e-04   5.5244e-02   3.2404e-02   2.0701e-01   2.1022e-01   8.7495e-01   8.1883e-02   9.7574e-01   8.4575e-02
-#> 182:    1.0245e+02  -4.1066e+00  -2.2849e+00  -4.0083e+00  -1.0260e+00  -1.9418e-01   1.0783e-01   1.7359e-04   2.9632e-02   3.2098e-02   2.0294e-01   1.7919e-01   9.0795e-01   9.1179e-02   9.8651e-01   8.3561e-02
-#> 183:    1.0248e+02  -4.1066e+00  -2.2844e+00  -4.0201e+00  -1.0102e+00  -1.5510e-01   9.2727e-02   1.4337e-04   2.8436e-02   4.3941e-02   1.9683e-01   2.1943e-01   9.0334e-01   8.2113e-02   8.9037e-01   8.4506e-02
-#> 184:    1.0239e+02  -4.1032e+00  -2.2726e+00  -4.0270e+00  -1.0162e+00  -1.4921e-01   9.0062e-02   1.0820e-04   3.5099e-02   4.7338e-02   1.8488e-01   2.2174e-01   9.1525e-01   7.9986e-02   8.6762e-01   8.4376e-02
-#> 185:    1.0240e+02  -4.1028e+00  -2.3201e+00  -4.0248e+00  -9.8758e-01  -1.7235e-01   9.2455e-02   8.9653e-05   4.7097e-02   4.5964e-02   1.9093e-01   1.9093e-01   9.5192e-01   7.6980e-02   9.4058e-01   8.2740e-02
-#> 186:    1.0250e+02  -4.1020e+00  -2.3095e+00  -4.0326e+00  -9.9767e-01  -1.2041e-01   1.0792e-01   7.3472e-05   3.6352e-02   4.6680e-02   1.7527e-01   1.7411e-01   9.6831e-01   8.3088e-02   9.7978e-01   8.1096e-02
-#> 187:    1.0254e+02  -4.1022e+00  -2.3078e+00  -4.0329e+00  -1.0166e+00  -1.1644e-01   8.2987e-02   7.9222e-05   3.8388e-02   6.0452e-02   2.3498e-01   1.7389e-01   1.0450e+00   8.0354e-02   9.7366e-01   8.2504e-02
-#> 188:    1.0253e+02  -4.1022e+00  -2.3172e+00  -4.0401e+00  -1.0276e+00  -8.2442e-02   8.3913e-02   7.1884e-05   4.3025e-02   4.8383e-02   1.9392e-01   1.6073e-01   9.7466e-01   7.5977e-02   9.0319e-01   8.4648e-02
-#> 189:    1.0256e+02  -4.1013e+00  -2.3037e+00  -4.0402e+00  -1.0004e+00  -1.5946e-01   9.6273e-02   8.0773e-05   4.6130e-02   5.2356e-02   2.1044e-01   2.0403e-01   9.2931e-01   8.2686e-02   9.0103e-01   8.5442e-02
-#> 190:    1.0245e+02  -4.1021e+00  -2.3143e+00  -4.0314e+00  -9.9314e-01  -8.5545e-02   8.0660e-02   7.3369e-05   4.1713e-02   4.4940e-02   1.7715e-01   1.6886e-01   9.7982e-01   8.1720e-02   8.9868e-01   8.4964e-02
-#> 191:    1.0251e+02  -4.1021e+00  -2.2849e+00  -4.0229e+00  -1.0346e+00  -9.0261e-02   6.1956e-02   9.4824e-05   5.8037e-02   4.0685e-02   1.8455e-01   2.2838e-01   9.9679e-01   7.7457e-02   9.4591e-01   8.5446e-02
-#> 192:    1.0249e+02  -4.1012e+00  -2.2915e+00  -4.0452e+00  -1.0323e+00  -1.1123e-01   5.1409e-02   1.1452e-04   7.2457e-02   3.6376e-02   1.6706e-01   2.1050e-01   8.7970e-01   8.6881e-02   9.2230e-01   8.6563e-02
-#> 193:    1.0249e+02  -4.1011e+00  -2.3104e+00  -4.0569e+00  -1.0032e+00  -2.9383e-02   4.2462e-02   9.6872e-05   4.9405e-02   4.6840e-02   1.7348e-01   1.4473e-01   9.1758e-01   8.1380e-02   1.0057e+00   8.4481e-02
-#> 194:    1.0250e+02  -4.1009e+00  -2.2960e+00  -4.0567e+00  -9.9145e-01  -1.0640e-01   2.6698e-02   5.3298e-05   4.3880e-02   5.1866e-02   2.0619e-01   1.4008e-01   9.8306e-01   8.0320e-02   9.8405e-01   8.0106e-02
-#> 195:    1.0252e+02  -4.1001e+00  -2.2779e+00  -4.0677e+00  -9.9960e-01  -5.5605e-02   1.9114e-02   5.6472e-05   4.5810e-02   5.1552e-02   1.8363e-01   1.2037e-01   9.9334e-01   8.2093e-02   9.9128e-01   8.3930e-02
-#> 196:    1.0251e+02  -4.0988e+00  -2.2515e+00  -4.0555e+00  -9.9701e-01  -1.0235e-01   1.3362e-02   3.2648e-05   4.0337e-02   4.4117e-02   1.9469e-01   1.2907e-01   9.1150e-01   8.5071e-02   9.7929e-01   8.2761e-02
-#> 197:    1.0253e+02  -4.0985e+00  -2.2589e+00  -4.0427e+00  -1.0251e+00  -9.4695e-02   1.7104e-02   2.3125e-05   4.1773e-02   3.3831e-02   2.1013e-01   1.3727e-01   9.1462e-01   8.1836e-02   9.7695e-01   8.1326e-02
-#> 198:    1.0253e+02  -4.0992e+00  -2.2745e+00  -4.0327e+00  -9.8743e-01  -1.4108e-01   9.3331e-03   2.3064e-05   3.7271e-02   2.7379e-02   2.1190e-01   9.3733e-02   9.0916e-01   8.4247e-02   9.8720e-01   7.7405e-02
-#> 199:    1.0251e+02  -4.0981e+00  -2.2770e+00  -4.0275e+00  -1.0216e+00  -1.3364e-01   8.3776e-03   2.3195e-05   4.6827e-02   3.2861e-02   1.9817e-01   8.7748e-02   9.1184e-01   8.3773e-02   9.5209e-01   7.9056e-02
-#> 200:    1.0252e+02  -4.0992e+00  -2.2757e+00  -4.0277e+00  -9.9266e-01  -8.4583e-02   6.8073e-03   2.9414e-05   5.3404e-02   2.5942e-02   1.9915e-01   7.4937e-02   8.7168e-01   8.5197e-02   9.3606e-01   8.0739e-02
-#> 201:    1.0252e+02  -4.0989e+00  -2.2706e+00  -4.0333e+00  -9.8978e-01  -8.7996e-02   5.9272e-03   2.4268e-05   5.4295e-02   2.9276e-02   2.0543e-01   7.1533e-02   9.0557e-01   8.3204e-02   9.4913e-01   8.0398e-02
-#> 202:    1.0251e+02  -4.0990e+00  -2.2661e+00  -4.0324e+00  -9.8785e-01  -9.8008e-02   5.7831e-03   2.1967e-05   5.7627e-02   3.0606e-02   2.1414e-01   6.9475e-02   9.2255e-01   8.2143e-02   9.5633e-01   8.1333e-02
-#> 203:    1.0251e+02  -4.0992e+00  -2.2586e+00  -4.0297e+00  -9.9017e-01  -1.1012e-01   6.4046e-03   2.2234e-05   5.7955e-02   3.0102e-02   2.0473e-01   6.8225e-02   9.2900e-01   8.3228e-02   9.5862e-01   8.1460e-02
-#> 204:    1.0251e+02  -4.0995e+00  -2.2570e+00  -4.0280e+00  -9.9135e-01  -1.0718e-01   6.5386e-03   2.2043e-05   5.6949e-02   2.9096e-02   2.0562e-01   6.8687e-02   9.3306e-01   8.2703e-02   9.6581e-01   8.1671e-02
-#> 205:    1.0250e+02  -4.0997e+00  -2.2569e+00  -4.0256e+00  -9.9350e-01  -1.1491e-01   6.1521e-03   2.2570e-05   5.5450e-02   2.8152e-02   2.0423e-01   7.2820e-02   9.2469e-01   8.3272e-02   9.7372e-01   8.0814e-02
-#> 206:    1.0250e+02  -4.0997e+00  -2.2567e+00  -4.0269e+00  -9.9869e-01  -1.1438e-01   5.9720e-03   2.3307e-05   5.5103e-02   2.8506e-02   2.0414e-01   7.8225e-02   9.2768e-01   8.3328e-02   9.8294e-01   8.0918e-02
-#> 207:    1.0250e+02  -4.0998e+00  -2.2657e+00  -4.0311e+00  -1.0000e+00  -1.0595e-01   6.0030e-03   2.4031e-05   5.4378e-02   2.9468e-02   2.0222e-01   8.1455e-02   9.3397e-01   8.3285e-02   9.8989e-01   8.0967e-02
-#> 208:    1.0250e+02  -4.0999e+00  -2.2759e+00  -4.0330e+00  -1.0001e+00  -9.6916e-02   5.9586e-03   2.3690e-05   5.3811e-02   2.9674e-02   1.9979e-01   8.1206e-02   9.3593e-01   8.4094e-02   9.8891e-01   8.1107e-02
-#> 209:    1.0250e+02  -4.0998e+00  -2.2836e+00  -4.0344e+00  -1.0016e+00  -8.9119e-02   5.6137e-03   2.3512e-05   5.4159e-02   2.9780e-02   1.9778e-01   8.2635e-02   9.4080e-01   8.3757e-02   9.9062e-01   8.0979e-02
-#> 210:    1.0251e+02  -4.0998e+00  -2.2898e+00  -4.0334e+00  -1.0017e+00  -8.3861e-02   5.2428e-03   2.3117e-05   5.4271e-02   2.9112e-02   1.9539e-01   8.3602e-02   9.4410e-01   8.4262e-02   9.8944e-01   8.1260e-02
-#> 211:    1.0251e+02  -4.0998e+00  -2.2968e+00  -4.0329e+00  -9.9953e-01  -8.2036e-02   4.9312e-03   2.2863e-05   5.5392e-02   2.8432e-02   1.9466e-01   8.3724e-02   9.5395e-01   8.4317e-02   9.9876e-01   8.1402e-02
-#> 212:    1.0251e+02  -4.0997e+00  -2.2982e+00  -4.0327e+00  -1.0018e+00  -8.2942e-02   4.6622e-03   2.3364e-05   5.5864e-02   2.7552e-02   1.9313e-01   8.3815e-02   9.5374e-01   8.4223e-02   1.0049e+00   8.1479e-02
-#> 213:    1.0251e+02  -4.0995e+00  -2.2996e+00  -4.0322e+00  -1.0027e+00  -8.4931e-02   4.4988e-03   2.4085e-05   5.6000e-02   2.6729e-02   1.9184e-01   8.3522e-02   9.5091e-01   8.4321e-02   1.0026e+00   8.1310e-02
-#> 214:    1.0251e+02  -4.0994e+00  -2.2997e+00  -4.0326e+00  -1.0033e+00  -8.7810e-02   4.3582e-03   2.5253e-05   5.6470e-02   2.6179e-02   1.9110e-01   8.5338e-02   9.5311e-01   8.4118e-02   1.0062e+00   8.1320e-02
-#> 215:    1.0251e+02  -4.0993e+00  -2.3013e+00  -4.0331e+00  -1.0042e+00  -8.5053e-02   4.3765e-03   2.6370e-05   5.6978e-02   2.5984e-02   1.8960e-01   8.6633e-02   9.5505e-01   8.3787e-02   1.0092e+00   8.1298e-02
-#> 216:    1.0251e+02  -4.0993e+00  -2.3032e+00  -4.0320e+00  -1.0033e+00  -8.5521e-02   4.4127e-03   2.7607e-05   5.7092e-02   2.5514e-02   1.8916e-01   8.8986e-02   9.5571e-01   8.3655e-02   1.0106e+00   8.1177e-02
-#> 217:    1.0251e+02  -4.0993e+00  -2.3050e+00  -4.0309e+00  -1.0039e+00  -8.5267e-02   4.4663e-03   2.8101e-05   5.7536e-02   2.5186e-02   1.8803e-01   9.0776e-02   9.5624e-01   8.3792e-02   1.0100e+00   8.1214e-02
-#> 218:    1.0251e+02  -4.0993e+00  -2.3068e+00  -4.0309e+00  -1.0052e+00  -8.3353e-02   4.4833e-03   2.7541e-05   5.7391e-02   2.4589e-02   1.8691e-01   9.4302e-02   9.5168e-01   8.4114e-02   1.0124e+00   8.1211e-02
-#> 219:    1.0251e+02  -4.0993e+00  -2.3077e+00  -4.0316e+00  -1.0049e+00  -8.0885e-02   4.4529e-03   2.6825e-05   5.7273e-02   2.3909e-02   1.8700e-01   9.6040e-02   9.4675e-01   8.4115e-02   1.0115e+00   8.1075e-02
-#> 220:    1.0251e+02  -4.0993e+00  -2.3095e+00  -4.0327e+00  -1.0051e+00  -7.6386e-02   4.5217e-03   2.6724e-05   5.7342e-02   2.3648e-02   1.8752e-01   9.7466e-02   9.4316e-01   8.4134e-02   1.0099e+00   8.1206e-02
-#> 221:    1.0251e+02  -4.0993e+00  -2.3120e+00  -4.0339e+00  -1.0050e+00  -7.3314e-02   4.5361e-03   2.6133e-05   5.7387e-02   2.3612e-02   1.8744e-01   9.9108e-02   9.4164e-01   8.4073e-02   1.0096e+00   8.1143e-02
-#> 222:    1.0251e+02  -4.0993e+00  -2.3136e+00  -4.0355e+00  -1.0049e+00  -6.8041e-02   4.5806e-03   2.5728e-05   5.7827e-02   2.3466e-02   1.8681e-01   9.9150e-02   9.4237e-01   8.3991e-02   1.0116e+00   8.1192e-02
-#> 223:    1.0251e+02  -4.0993e+00  -2.3144e+00  -4.0364e+00  -1.0047e+00  -6.6770e-02   4.5349e-03   2.5412e-05   5.8823e-02   2.3232e-02   1.8728e-01   9.9882e-02   9.4051e-01   8.3808e-02   1.0097e+00   8.1028e-02
-#> 224:    1.0251e+02  -4.0992e+00  -2.3155e+00  -4.0373e+00  -1.0040e+00  -6.4487e-02   4.4985e-03   2.5094e-05   6.0294e-02   2.3022e-02   1.8652e-01   1.0114e-01   9.3800e-01   8.3696e-02   1.0099e+00   8.0990e-02
-#> 225:    1.0251e+02  -4.0992e+00  -2.3167e+00  -4.0384e+00  -1.0041e+00  -6.2966e-02   4.4783e-03   2.4741e-05   6.0569e-02   2.2900e-02   1.8622e-01   1.0072e-01   9.3574e-01   8.3833e-02   1.0075e+00   8.0893e-02
-#> 226:    1.0251e+02  -4.0993e+00  -2.3173e+00  -4.0395e+00  -1.0036e+00  -6.0541e-02   4.4466e-03   2.4601e-05   6.0661e-02   2.2897e-02   1.8544e-01   1.0160e-01   9.3842e-01   8.3565e-02   1.0064e+00   8.1006e-02
-#> 227:    1.0251e+02  -4.0993e+00  -2.3183e+00  -4.0403e+00  -1.0028e+00  -5.9061e-02   4.4290e-03   2.4610e-05   6.1093e-02   2.2836e-02   1.8582e-01   1.0184e-01   9.3983e-01   8.3421e-02   1.0066e+00   8.1225e-02
-#> 228:    1.0251e+02  -4.0993e+00  -2.3190e+00  -4.0405e+00  -1.0027e+00  -5.8994e-02   4.4377e-03   2.4228e-05   6.0957e-02   2.2540e-02   1.8424e-01   1.0104e-01   9.4056e-01   8.3559e-02   1.0085e+00   8.1266e-02
-#> 229:    1.0251e+02  -4.0993e+00  -2.3206e+00  -4.0398e+00  -1.0026e+00  -5.9258e-02   4.5021e-03   2.3801e-05   6.0331e-02   2.2380e-02   1.8409e-01   9.9681e-02   9.4320e-01   8.3678e-02   1.0111e+00   8.1236e-02
-#> 230:    1.0251e+02  -4.0994e+00  -2.3217e+00  -4.0401e+00  -1.0028e+00  -5.7766e-02   4.5320e-03   2.3519e-05   5.9913e-02   2.2317e-02   1.8484e-01   9.9325e-02   9.4418e-01   8.3884e-02   1.0144e+00   8.1294e-02
-#> 231:    1.0251e+02  -4.0994e+00  -2.3223e+00  -4.0400e+00  -1.0036e+00  -5.7213e-02   4.6519e-03   2.3658e-05   5.9386e-02   2.2185e-02   1.8526e-01   9.8374e-02   9.4356e-01   8.4167e-02   1.0171e+00   8.1315e-02
-#> 232:    1.0251e+02  -4.0994e+00  -2.3231e+00  -4.0400e+00  -1.0045e+00  -5.5248e-02   4.7067e-03   2.3117e-05   5.9583e-02   2.2248e-02   1.8574e-01   9.7396e-02   9.4340e-01   8.4212e-02   1.0179e+00   8.1401e-02
-#> 233:    1.0251e+02  -4.0994e+00  -2.3237e+00  -4.0401e+00  -1.0046e+00  -5.4085e-02   4.7534e-03   2.2858e-05   5.8985e-02   2.2248e-02   1.8649e-01   9.7364e-02   9.4271e-01   8.4248e-02   1.0189e+00   8.1456e-02
-#> 234:    1.0251e+02  -4.0995e+00  -2.3238e+00  -4.0400e+00  -1.0042e+00  -5.2957e-02   4.8433e-03   2.2715e-05   5.8868e-02   2.2174e-02   1.8630e-01   9.7975e-02   9.4382e-01   8.4160e-02   1.0210e+00   8.1665e-02
-#> 235:    1.0251e+02  -4.0995e+00  -2.3248e+00  -4.0396e+00  -1.0044e+00  -5.3132e-02   4.8769e-03   2.2540e-05   5.9052e-02   2.2120e-02   1.8627e-01   9.8772e-02   9.4330e-01   8.4170e-02   1.0196e+00   8.1627e-02
-#> 236:    1.0251e+02  -4.0995e+00  -2.3244e+00  -4.0392e+00  -1.0052e+00  -5.3786e-02   4.8860e-03   2.2664e-05   5.8981e-02   2.2095e-02   1.8771e-01   9.8852e-02   9.4172e-01   8.4214e-02   1.0191e+00   8.1698e-02
-#> 237:    1.0251e+02  -4.0996e+00  -2.3231e+00  -4.0386e+00  -1.0056e+00  -5.5158e-02   4.8731e-03   2.2576e-05   5.8788e-02   2.2037e-02   1.8860e-01   9.9599e-02   9.4242e-01   8.4097e-02   1.0198e+00   8.1684e-02
-#> 238:    1.0251e+02  -4.0996e+00  -2.3222e+00  -4.0384e+00  -1.0054e+00  -5.6412e-02   4.8673e-03   2.2575e-05   5.8733e-02   2.1962e-02   1.8874e-01   9.9196e-02   9.4097e-01   8.4103e-02   1.0208e+00   8.1649e-02
-#> 239:    1.0251e+02  -4.0996e+00  -2.3212e+00  -4.0382e+00  -1.0068e+00  -5.7131e-02   4.8223e-03   2.2398e-05   5.8674e-02   2.1817e-02   1.8926e-01   9.9323e-02   9.4261e-01   8.4059e-02   1.0229e+00   8.1670e-02
-#> 240:    1.0251e+02  -4.0996e+00  -2.3216e+00  -4.0376e+00  -1.0073e+00  -5.6962e-02   4.7984e-03   2.2260e-05   5.8558e-02   2.1632e-02   1.8892e-01   9.9232e-02   9.4434e-01   8.4130e-02   1.0237e+00   8.1679e-02
-#> 241:    1.0251e+02  -4.0996e+00  -2.3216e+00  -4.0371e+00  -1.0078e+00  -5.6984e-02   4.7767e-03   2.2074e-05   5.9552e-02   2.1436e-02   1.8860e-01   9.9285e-02   9.4491e-01   8.4026e-02   1.0247e+00   8.1680e-02
-#> 242:    1.0251e+02  -4.0996e+00  -2.3222e+00  -4.0372e+00  -1.0079e+00  -5.6422e-02   4.7880e-03   2.2014e-05   6.0033e-02   2.1277e-02   1.8860e-01   9.8674e-02   9.4359e-01   8.3991e-02   1.0255e+00   8.1634e-02
-#> 243:    1.0251e+02  -4.0995e+00  -2.3227e+00  -4.0376e+00  -1.0079e+00  -5.4330e-02   4.7944e-03   2.1687e-05   6.0189e-02   2.1088e-02   1.8830e-01   9.7952e-02   9.4207e-01   8.4036e-02   1.0257e+00   8.1666e-02
-#> 244:    1.0251e+02  -4.0995e+00  -2.3237e+00  -4.0385e+00  -1.0076e+00  -5.2834e-02   4.7916e-03   2.1467e-05   6.0432e-02   2.1062e-02   1.8810e-01   9.7065e-02   9.4039e-01   8.4075e-02   1.0248e+00   8.1599e-02
-#> 245:    1.0251e+02  -4.0995e+00  -2.3249e+00  -4.0390e+00  -1.0073e+00  -5.0542e-02   4.7926e-03   2.1549e-05   6.1095e-02   2.0981e-02   1.8814e-01   9.6715e-02   9.3900e-01   8.4049e-02   1.0226e+00   8.1505e-02
-#> 246:    1.0251e+02  -4.0995e+00  -2.3261e+00  -4.0398e+00  -1.0066e+00  -4.7686e-02   4.8114e-03   2.1557e-05   6.1692e-02   2.0969e-02   1.8783e-01   9.6477e-02   9.3880e-01   8.4024e-02   1.0211e+00   8.1456e-02
-#> 247:    1.0251e+02  -4.0996e+00  -2.3270e+00  -4.0406e+00  -1.0063e+00  -4.5794e-02   4.7864e-03   2.1709e-05   6.1819e-02   2.0928e-02   1.8765e-01   9.5549e-02   9.3939e-01   8.4076e-02   1.0201e+00   8.1427e-02
-#> 248:    1.0251e+02  -4.0995e+00  -2.3282e+00  -4.0412e+00  -1.0064e+00  -4.3009e-02   4.7307e-03   2.1707e-05   6.2309e-02   2.0970e-02   1.8795e-01   9.5221e-02   9.3898e-01   8.4080e-02   1.0197e+00   8.1501e-02
-#> 249:    1.0251e+02  -4.0996e+00  -2.3298e+00  -4.0417e+00  -1.0070e+00  -4.1062e-02   4.7070e-03   2.1737e-05   6.2607e-02   2.1094e-02   1.8796e-01   9.5103e-02   9.3917e-01   8.4069e-02   1.0194e+00   8.1525e-02
-#> 250:    1.0251e+02  -4.0996e+00  -2.3313e+00  -4.0420e+00  -1.0073e+00  -3.9250e-02   4.7191e-03   2.1947e-05   6.2963e-02   2.1053e-02   1.8834e-01   9.4954e-02   9.3851e-01   8.4115e-02   1.0190e+00   8.1496e-02
-#> 251:    1.0251e+02  -4.0997e+00  -2.3317e+00  -4.0424e+00  -1.0078e+00  -3.7549e-02   4.7501e-03   2.2063e-05   6.3160e-02   2.0958e-02   1.8840e-01   9.4783e-02   9.3749e-01   8.4137e-02   1.0185e+00   8.1476e-02
-#> 252:    1.0251e+02  -4.0997e+00  -2.3319e+00  -4.0424e+00  -1.0083e+00  -3.6657e-02   4.7441e-03   2.2081e-05   6.3250e-02   2.0891e-02   1.8911e-01   9.4954e-02   9.3708e-01   8.4108e-02   1.0180e+00   8.1479e-02
-#> 253:    1.0251e+02  -4.0997e+00  -2.3323e+00  -4.0425e+00  -1.0085e+00  -3.5826e-02   4.7409e-03   2.2021e-05   6.3513e-02   2.0810e-02   1.8920e-01   9.5196e-02   9.3509e-01   8.4179e-02   1.0184e+00   8.1440e-02
-#> 254:    1.0251e+02  -4.0997e+00  -2.3324e+00  -4.0426e+00  -1.0086e+00  -3.6456e-02   4.7046e-03   2.1929e-05   6.3535e-02   2.0859e-02   1.9010e-01   9.5077e-02   9.3362e-01   8.4279e-02   1.0185e+00   8.1371e-02
-#> 255:    1.0251e+02  -4.0997e+00  -2.3313e+00  -4.0424e+00  -1.0088e+00  -3.7358e-02   4.6636e-03   2.1827e-05   6.3864e-02   2.0820e-02   1.9126e-01   9.4979e-02   9.3183e-01   8.4380e-02   1.0185e+00   8.1434e-02
-#> 256:    1.0251e+02  -4.0997e+00  -2.3306e+00  -4.0423e+00  -1.0086e+00  -3.8558e-02   4.6418e-03   2.1776e-05   6.4176e-02   2.0845e-02   1.9175e-01   9.4890e-02   9.3144e-01   8.4436e-02   1.0188e+00   8.1420e-02
-#> 257:    1.0251e+02  -4.0997e+00  -2.3297e+00  -4.0419e+00  -1.0092e+00  -3.9580e-02   4.6134e-03   2.1742e-05   6.4408e-02   2.0751e-02   1.9188e-01   9.4692e-02   9.3113e-01   8.4507e-02   1.0187e+00   8.1412e-02
-#> 258:    1.0251e+02  -4.0997e+00  -2.3287e+00  -4.0415e+00  -1.0090e+00  -4.0619e-02   4.5918e-03   2.1710e-05   6.4634e-02   2.0663e-02   1.9172e-01   9.4422e-02   9.3104e-01   8.4479e-02   1.0189e+00   8.1395e-02
-#> 259:    1.0251e+02  -4.0997e+00  -2.3284e+00  -4.0412e+00  -1.0086e+00  -4.1245e-02   4.5889e-03   2.1741e-05   6.5035e-02   2.0678e-02   1.9132e-01   9.3998e-02   9.2986e-01   8.4448e-02   1.0177e+00   8.1368e-02
-#> 260:    1.0251e+02  -4.0997e+00  -2.3283e+00  -4.0410e+00  -1.0084e+00  -4.1907e-02   4.5818e-03   2.1877e-05   6.5755e-02   2.0691e-02   1.9113e-01   9.3631e-02   9.2955e-01   8.4378e-02   1.0172e+00   8.1346e-02
-#> 261:    1.0251e+02  -4.0998e+00  -2.3282e+00  -4.0409e+00  -1.0087e+00  -4.2022e-02   4.5724e-03   2.1946e-05   6.6396e-02   2.0714e-02   1.9084e-01   9.3140e-02   9.2882e-01   8.4426e-02   1.0166e+00   8.1329e-02
-#> 262:    1.0251e+02  -4.0997e+00  -2.3275e+00  -4.0408e+00  -1.0092e+00  -4.2439e-02   4.5357e-03   2.1842e-05   6.6895e-02   2.0692e-02   1.9082e-01   9.2527e-02   9.2811e-01   8.4447e-02   1.0168e+00   8.1339e-02
-#> 263:    1.0251e+02  -4.0998e+00  -2.3269e+00  -4.0407e+00  -1.0097e+00  -4.2867e-02   4.5244e-03   2.1830e-05   6.7068e-02   2.0721e-02   1.9077e-01   9.2003e-02   9.2800e-01   8.4366e-02   1.0171e+00   8.1343e-02
-#> 264:    1.0251e+02  -4.0998e+00  -2.3262e+00  -4.0403e+00  -1.0102e+00  -4.3066e-02   4.4987e-03   2.1812e-05   6.7458e-02   2.0718e-02   1.9065e-01   9.1528e-02   9.2710e-01   8.4389e-02   1.0163e+00   8.1355e-02
-#> 265:    1.0251e+02  -4.0998e+00  -2.3264e+00  -4.0401e+00  -1.0105e+00  -4.3042e-02   4.4865e-03   2.1721e-05   6.7680e-02   2.0722e-02   1.9057e-01   9.1243e-02   9.2631e-01   8.4430e-02   1.0154e+00   8.1321e-02
-#> 266:    1.0251e+02  -4.0998e+00  -2.3264e+00  -4.0397e+00  -1.0107e+00  -4.3247e-02   4.4552e-03   2.1609e-05   6.8246e-02   2.0757e-02   1.9054e-01   9.1222e-02   9.2659e-01   8.4381e-02   1.0154e+00   8.1290e-02
-#> 267:    1.0251e+02  -4.0999e+00  -2.3261e+00  -4.0396e+00  -1.0107e+00  -4.4145e-02   4.4367e-03   2.1505e-05   6.8834e-02   2.0735e-02   1.9038e-01   9.1594e-02   9.2661e-01   8.4338e-02   1.0153e+00   8.1308e-02
-#> 268:    1.0251e+02  -4.0999e+00  -2.3249e+00  -4.0395e+00  -1.0112e+00  -4.5394e-02   4.4239e-03   2.1411e-05   6.9776e-02   2.0749e-02   1.9017e-01   9.1916e-02   9.2711e-01   8.4286e-02   1.0158e+00   8.1400e-02
-#> 269:    1.0251e+02  -4.0999e+00  -2.3236e+00  -4.0391e+00  -1.0112e+00  -4.6744e-02   4.4119e-03   2.1310e-05   7.0528e-02   2.0709e-02   1.9026e-01   9.2008e-02   9.2638e-01   8.4248e-02   1.0160e+00   8.1389e-02
-#> 270:    1.0251e+02  -4.0999e+00  -2.3231e+00  -4.0388e+00  -1.0116e+00  -4.7514e-02   4.3782e-03   2.1160e-05   7.1513e-02   2.0724e-02   1.9006e-01   9.1551e-02   9.2668e-01   8.4246e-02   1.0149e+00   8.1419e-02
-#> 271:    1.0251e+02  -4.0999e+00  -2.3228e+00  -4.0387e+00  -1.0117e+00  -4.7755e-02   4.3389e-03   2.1121e-05   7.1868e-02   2.0670e-02   1.8969e-01   9.1369e-02   9.2678e-01   8.4228e-02   1.0145e+00   8.1437e-02
-#> 272:    1.0251e+02  -4.0999e+00  -2.3222e+00  -4.0387e+00  -1.0121e+00  -4.8163e-02   4.3080e-03   2.1146e-05   7.2226e-02   2.0710e-02   1.8983e-01   9.0962e-02   9.2639e-01   8.4261e-02   1.0132e+00   8.1523e-02
-#> 273:    1.0251e+02  -4.0999e+00  -2.3216e+00  -4.0389e+00  -1.0122e+00  -4.8336e-02   4.2916e-03   2.1202e-05   7.2734e-02   2.0689e-02   1.8982e-01   9.0422e-02   9.2618e-01   8.4177e-02   1.0134e+00   8.1561e-02
-#> 274:    1.0251e+02  -4.0999e+00  -2.3211e+00  -4.0388e+00  -1.0124e+00  -4.8286e-02   4.2592e-03   2.1201e-05   7.3324e-02   2.0658e-02   1.9015e-01   8.9938e-02   9.2530e-01   8.4133e-02   1.0133e+00   8.1562e-02
-#> 275:    1.0251e+02  -4.0999e+00  -2.3211e+00  -4.0387e+00  -1.0128e+00  -4.8312e-02   4.2368e-03   2.1092e-05   7.3673e-02   2.0639e-02   1.9018e-01   8.9708e-02   9.2404e-01   8.4155e-02   1.0130e+00   8.1535e-02
-#> 276:    1.0251e+02  -4.0999e+00  -2.3212e+00  -4.0386e+00  -1.0126e+00  -4.8249e-02   4.2070e-03   2.0985e-05   7.4089e-02   2.0674e-02   1.8992e-01   8.9341e-02   9.2339e-01   8.4163e-02   1.0121e+00   8.1515e-02
-#> 277:    1.0251e+02  -4.0999e+00  -2.3212e+00  -4.0387e+00  -1.0123e+00  -4.8743e-02   4.1781e-03   2.0914e-05   7.4488e-02   2.0779e-02   1.8959e-01   8.9106e-02   9.2352e-01   8.4100e-02   1.0112e+00   8.1477e-02
-#> 278:    1.0251e+02  -4.0999e+00  -2.3213e+00  -4.0385e+00  -1.0118e+00  -4.9468e-02   4.1782e-03   2.0802e-05   7.4843e-02   2.0859e-02   1.8970e-01   8.8995e-02   9.2374e-01   8.4037e-02   1.0103e+00   8.1458e-02
-#> 279:    1.0251e+02  -4.0999e+00  -2.3213e+00  -4.0384e+00  -1.0115e+00  -4.9612e-02   4.1736e-03   2.0737e-05   7.5385e-02   2.0899e-02   1.8969e-01   8.8806e-02   9.2347e-01   8.3989e-02   1.0095e+00   8.1440e-02
-#> 280:    1.0251e+02  -4.0999e+00  -2.3213e+00  -4.0382e+00  -1.0114e+00  -5.0460e-02   4.1900e-03   2.0708e-05   7.6051e-02   2.0933e-02   1.8968e-01   8.9243e-02   9.2293e-01   8.3972e-02   1.0085e+00   8.1467e-02
-#> 281:    1.0251e+02  -4.0999e+00  -2.3215e+00  -4.0378e+00  -1.0113e+00  -5.0583e-02   4.2096e-03   2.0638e-05   7.6759e-02   2.1003e-02   1.8941e-01   8.9450e-02   9.2294e-01   8.4027e-02   1.0080e+00   8.1467e-02
-#> 282:    1.0251e+02  -4.0999e+00  -2.3218e+00  -4.0380e+00  -1.0114e+00  -5.0276e-02   4.2061e-03   2.0669e-05   7.7323e-02   2.1016e-02   1.8946e-01   8.9456e-02   9.2386e-01   8.3996e-02   1.0095e+00   8.1446e-02
-#> 283:    1.0251e+02  -4.0999e+00  -2.3224e+00  -4.0383e+00  -1.0115e+00  -4.9357e-02   4.2005e-03   2.0601e-05   7.7856e-02   2.1072e-02   1.8968e-01   8.9327e-02   9.2480e-01   8.3964e-02   1.0101e+00   8.1418e-02
-#> 284:    1.0251e+02  -4.0999e+00  -2.3226e+00  -4.0386e+00  -1.0110e+00  -4.8703e-02   4.1977e-03   2.0549e-05   7.8183e-02   2.1122e-02   1.8956e-01   8.9430e-02   9.2470e-01   8.3898e-02   1.0098e+00   8.1428e-02
-#> 285:    1.0251e+02  -4.0999e+00  -2.3232e+00  -4.0389e+00  -1.0110e+00  -4.7526e-02   4.2063e-03   2.0546e-05   7.8449e-02   2.1151e-02   1.8967e-01   8.9133e-02   9.2438e-01   8.3889e-02   1.0089e+00   8.1428e-02
-#> 286:    1.0251e+02  -4.0999e+00  -2.3242e+00  -4.0389e+00  -1.0103e+00  -4.6191e-02   4.2076e-03   2.0486e-05   7.8629e-02   2.1133e-02   1.8970e-01   8.8773e-02   9.2471e-01   8.3861e-02   1.0087e+00   8.1427e-02
-#> 287:    1.0251e+02  -4.0999e+00  -2.3243e+00  -4.0391e+00  -1.0105e+00  -4.5159e-02   4.1980e-03   2.0488e-05   7.8916e-02   2.1071e-02   1.8955e-01   8.8297e-02   9.2415e-01   8.3957e-02   1.0084e+00   8.1464e-02
-#> 288:    1.0251e+02  -4.0999e+00  -2.3237e+00  -4.0392e+00  -1.0109e+00  -4.4970e-02   4.1921e-03   2.0495e-05   7.8764e-02   2.0953e-02   1.8988e-01   8.8160e-02   9.2539e-01   8.3963e-02   1.0103e+00   8.1466e-02
-#> 289:    1.0251e+02  -4.0999e+00  -2.3232e+00  -4.0392e+00  -1.0114e+00  -4.4592e-02   4.1763e-03   2.0584e-05   7.8632e-02   2.0841e-02   1.8982e-01   8.8037e-02   9.2559e-01   8.4031e-02   1.0111e+00   8.1469e-02
-#> 290:    1.0251e+02  -4.0999e+00  -2.3228e+00  -4.0393e+00  -1.0118e+00  -4.4506e-02   4.1574e-03   2.0479e-05   7.8482e-02   2.0726e-02   1.8968e-01   8.7644e-02   9.2519e-01   8.4079e-02   1.0117e+00   8.1474e-02
-#> 291:    1.0251e+02  -4.0999e+00  -2.3223e+00  -4.0392e+00  -1.0120e+00  -4.4578e-02   4.1365e-03   2.0488e-05   7.8220e-02   2.0662e-02   1.8952e-01   8.7558e-02   9.2534e-01   8.4128e-02   1.0119e+00   8.1459e-02
-#> 292:    1.0251e+02  -4.0999e+00  -2.3219e+00  -4.0392e+00  -1.0120e+00  -4.4486e-02   4.1205e-03   2.0514e-05   7.8288e-02   2.0601e-02   1.8947e-01   8.7669e-02   9.2591e-01   8.4106e-02   1.0124e+00   8.1443e-02
-#> 293:    1.0251e+02  -4.0999e+00  -2.3217e+00  -4.0395e+00  -1.0120e+00  -4.3914e-02   4.1076e-03   2.0606e-05   7.8474e-02   2.0557e-02   1.8960e-01   8.7970e-02   9.2580e-01   8.4052e-02   1.0124e+00   8.1443e-02
-#> 294:    1.0251e+02  -4.0998e+00  -2.3218e+00  -4.0399e+00  -1.0123e+00  -4.3173e-02   4.1124e-03   2.0598e-05   7.8561e-02   2.0485e-02   1.8979e-01   8.7954e-02   9.2624e-01   8.4027e-02   1.0132e+00   8.1419e-02
-#> 295:    1.0251e+02  -4.0998e+00  -2.3220e+00  -4.0399e+00  -1.0123e+00  -4.2805e-02   4.1150e-03   2.0599e-05   7.8804e-02   2.0397e-02   1.8985e-01   8.8079e-02   9.2637e-01   8.3980e-02   1.0139e+00   8.1382e-02
-#> 296:    1.0251e+02  -4.0998e+00  -2.3224e+00  -4.0401e+00  -1.0121e+00  -4.2813e-02   4.1342e-03   2.0618e-05   7.9093e-02   2.0359e-02   1.8980e-01   8.8328e-02   9.2555e-01   8.3955e-02   1.0137e+00   8.1344e-02
-#> 297:    1.0251e+02  -4.0998e+00  -2.3225e+00  -4.0403e+00  -1.0118e+00  -4.2861e-02   4.1653e-03   2.0599e-05   7.9236e-02   2.0318e-02   1.8969e-01   8.8659e-02   9.2477e-01   8.3916e-02   1.0135e+00   8.1323e-02
-#> 298:    1.0251e+02  -4.0997e+00  -2.3228e+00  -4.0404e+00  -1.0116e+00  -4.2874e-02   4.2066e-03   2.0567e-05   7.9391e-02   2.0249e-02   1.8973e-01   8.8706e-02   9.2359e-01   8.3939e-02   1.0134e+00   8.1277e-02
-#> 299:    1.0251e+02  -4.0997e+00  -2.3224e+00  -4.0404e+00  -1.0113e+00  -4.3190e-02   4.2168e-03   2.0532e-05   7.9379e-02   2.0187e-02   1.8973e-01   8.8757e-02   9.2294e-01   8.3916e-02   1.0137e+00   8.1243e-02
-#> 300:    1.0251e+02  -4.0997e+00  -2.3221e+00  -4.0405e+00  -1.0111e+00  -4.3480e-02   4.2289e-03   2.0490e-05   7.9314e-02   2.0140e-02   1.8983e-01   8.8620e-02   9.2242e-01   8.3900e-02   1.0137e+00   8.1210e-02
-#> 301:    1.0251e+02  -4.0997e+00  -2.3213e+00  -4.0404e+00  -1.0109e+00  -4.4169e-02   4.2524e-03   2.0546e-05   7.9499e-02   2.0117e-02   1.8991e-01   8.8503e-02   9.2226e-01   8.3843e-02   1.0136e+00   8.1235e-02
-#> 302:    1.0251e+02  -4.0997e+00  -2.3205e+00  -4.0403e+00  -1.0108e+00  -4.5199e-02   4.2709e-03   2.0511e-05   7.9674e-02   2.0085e-02   1.8969e-01   8.8687e-02   9.2207e-01   8.3852e-02   1.0134e+00   8.1262e-02
-#> 303:    1.0251e+02  -4.0997e+00  -2.3199e+00  -4.0401e+00  -1.0106e+00  -4.6193e-02   4.2807e-03   2.0440e-05   7.9845e-02   2.0104e-02   1.8985e-01   8.8661e-02   9.2135e-01   8.3843e-02   1.0128e+00   8.1274e-02
-#> 304:    1.0251e+02  -4.0997e+00  -2.3189e+00  -4.0398e+00  -1.0105e+00  -4.7180e-02   4.3058e-03   2.0450e-05   7.9808e-02   2.0159e-02   1.8987e-01   8.8660e-02   9.2076e-01   8.3856e-02   1.0120e+00   8.1277e-02
-#> 305:    1.0251e+02  -4.0997e+00  -2.3180e+00  -4.0396e+00  -1.0102e+00  -4.8474e-02   4.3050e-03   2.0527e-05   7.9932e-02   2.0184e-02   1.8970e-01   8.8567e-02   9.1986e-01   8.3867e-02   1.0111e+00   8.1290e-02
-#> 306:    1.0251e+02  -4.0997e+00  -2.3175e+00  -4.0393e+00  -1.0101e+00  -4.9308e-02   4.3055e-03   2.0586e-05   8.0113e-02   2.0178e-02   1.8971e-01   8.8307e-02   9.1930e-01   8.3865e-02   1.0112e+00   8.1290e-02
-#> 307:    1.0251e+02  -4.0997e+00  -2.3175e+00  -4.0393e+00  -1.0103e+00  -4.9278e-02   4.3027e-03   2.0441e-05   8.0168e-02   2.0211e-02   1.8973e-01   8.7993e-02   9.1919e-01   8.3837e-02   1.0109e+00   8.1287e-02
-#> 308:    1.0251e+02  -4.0998e+00  -2.3175e+00  -4.0394e+00  -1.0103e+00  -4.9430e-02   4.2899e-03   2.0384e-05   8.0417e-02   2.0187e-02   1.8983e-01   8.7757e-02   9.1937e-01   8.3778e-02   1.0106e+00   8.1289e-02
-#> 309:    1.0251e+02  -4.0998e+00  -2.3175e+00  -4.0393e+00  -1.0103e+00  -4.9319e-02   4.2773e-03   2.0349e-05   8.0807e-02   2.0161e-02   1.8959e-01   8.7493e-02   9.1950e-01   8.3734e-02   1.0108e+00   8.1279e-02
-#> 310:    1.0251e+02  -4.0998e+00  -2.3174e+00  -4.0393e+00  -1.0101e+00  -4.8880e-02   4.2710e-03   2.0327e-05   8.1202e-02   2.0116e-02   1.8983e-01   8.7251e-02   9.1864e-01   8.3730e-02   1.0108e+00   8.1294e-02
-#> 311:    1.0251e+02  -4.0998e+00  -2.3174e+00  -4.0394e+00  -1.0100e+00  -4.8080e-02   4.2611e-03   2.0272e-05   8.1332e-02   2.0078e-02   1.9003e-01   8.6995e-02   9.1844e-01   8.3699e-02   1.0105e+00   8.1319e-02
-#> 312:    1.0251e+02  -4.0998e+00  -2.3173e+00  -4.0394e+00  -1.0100e+00  -4.7724e-02   4.2663e-03   2.0239e-05   8.1553e-02   2.0021e-02   1.8982e-01   8.6721e-02   9.1838e-01   8.3721e-02   1.0100e+00   8.1312e-02
-#> 313:    1.0251e+02  -4.0998e+00  -2.3170e+00  -4.0395e+00  -1.0100e+00  -4.7216e-02   4.2775e-03   2.0213e-05   8.2001e-02   1.9971e-02   1.8980e-01   8.6651e-02   9.1837e-01   8.3697e-02   1.0100e+00   8.1318e-02
-#> 314:    1.0251e+02  -4.0998e+00  -2.3169e+00  -4.0398e+00  -1.0100e+00  -4.6902e-02   4.2949e-03   2.0265e-05   8.2392e-02   1.9922e-02   1.8988e-01   8.6426e-02   9.1845e-01   8.3722e-02   1.0103e+00   8.1309e-02
-#> 315:    1.0251e+02  -4.0998e+00  -2.3168e+00  -4.0399e+00  -1.0102e+00  -4.6480e-02   4.3206e-03   2.0314e-05   8.2534e-02   1.9912e-02   1.8972e-01   8.6211e-02   9.1792e-01   8.3758e-02   1.0103e+00   8.1337e-02
-#> 316:    1.0251e+02  -4.0998e+00  -2.3169e+00  -4.0400e+00  -1.0100e+00  -4.6238e-02   4.3456e-03   2.0323e-05   8.2729e-02   1.9936e-02   1.8975e-01   8.5856e-02   9.1759e-01   8.3814e-02   1.0095e+00   8.1353e-02
-#> 317:    1.0251e+02  -4.0998e+00  -2.3169e+00  -4.0402e+00  -1.0103e+00  -4.5470e-02   4.3521e-03   2.0275e-05   8.2864e-02   1.9965e-02   1.8980e-01   8.5438e-02   9.1755e-01   8.3894e-02   1.0088e+00   8.1373e-02
-#> 318:    1.0251e+02  -4.0998e+00  -2.3169e+00  -4.0402e+00  -1.0106e+00  -4.5001e-02   4.3661e-03   2.0191e-05   8.2949e-02   1.9983e-02   1.9001e-01   8.5203e-02   9.1746e-01   8.3944e-02   1.0078e+00   8.1401e-02
-#> 319:    1.0251e+02  -4.0998e+00  -2.3169e+00  -4.0403e+00  -1.0108e+00  -4.4545e-02   4.3665e-03   2.0114e-05   8.2694e-02   2.0003e-02   1.9041e-01   8.4997e-02   9.1774e-01   8.3940e-02   1.0073e+00   8.1417e-02
-#> 320:    1.0251e+02  -4.0998e+00  -2.3171e+00  -4.0402e+00  -1.0109e+00  -4.4419e-02   4.3600e-03   2.0043e-05   8.2516e-02   1.9999e-02   1.9044e-01   8.4873e-02   9.1798e-01   8.3932e-02   1.0070e+00   8.1420e-02
-#> 321:    1.0251e+02  -4.0998e+00  -2.3170e+00  -4.0401e+00  -1.0107e+00  -4.4267e-02   4.3539e-03   1.9995e-05   8.2307e-02   1.9967e-02   1.9050e-01   8.4982e-02   9.1814e-01   8.3919e-02   1.0067e+00   8.1429e-02
-#> 322:    1.0251e+02  -4.0998e+00  -2.3170e+00  -4.0400e+00  -1.0106e+00  -4.4240e-02   4.3331e-03   1.9984e-05   8.2305e-02   1.9961e-02   1.9054e-01   8.5443e-02   9.1821e-01   8.3910e-02   1.0065e+00   8.1424e-02
-#> 323:    1.0251e+02  -4.0998e+00  -2.3166e+00  -4.0397e+00  -1.0105e+00  -4.4793e-02   4.3199e-03   1.9921e-05   8.2300e-02   1.9935e-02   1.9078e-01   8.6081e-02   9.1836e-01   8.3854e-02   1.0062e+00   8.1448e-02
-#> 324:    1.0251e+02  -4.0998e+00  -2.3167e+00  -4.0395e+00  -1.0104e+00  -4.4862e-02   4.3167e-03   1.9926e-05   8.2063e-02   1.9919e-02   1.9086e-01   8.6736e-02   9.1865e-01   8.3834e-02   1.0060e+00   8.1439e-02
-#> 325:    1.0251e+02  -4.0998e+00  -2.3166e+00  -4.0394e+00  -1.0103e+00  -4.5123e-02   4.3012e-03   1.9902e-05   8.1871e-02   1.9888e-02   1.9103e-01   8.7030e-02   9.1829e-01   8.3865e-02   1.0059e+00   8.1436e-02
-#> 326:    1.0251e+02  -4.0998e+00  -2.3166e+00  -4.0393e+00  -1.0100e+00  -4.5111e-02   4.2839e-03   1.9869e-05   8.2016e-02   1.9843e-02   1.9083e-01   8.7106e-02   9.1802e-01   8.3847e-02   1.0058e+00   8.1427e-02
-#> 327:    1.0251e+02  -4.0998e+00  -2.3165e+00  -4.0393e+00  -1.0101e+00  -4.5297e-02   4.2847e-03   1.9858e-05   8.2297e-02   1.9823e-02   1.9075e-01   8.7398e-02   9.1826e-01   8.3771e-02   1.0054e+00   8.1451e-02
-#> 328:    1.0251e+02  -4.0998e+00  -2.3162e+00  -4.0393e+00  -1.0100e+00  -4.5633e-02   4.2864e-03   1.9877e-05   8.2486e-02   1.9809e-02   1.9060e-01   8.7863e-02   9.1822e-01   8.3706e-02   1.0049e+00   8.1482e-02
-#> 329:    1.0251e+02  -4.0998e+00  -2.3163e+00  -4.0392e+00  -1.0098e+00  -4.5698e-02   4.3097e-03   1.9869e-05   8.2469e-02   1.9795e-02   1.9047e-01   8.8220e-02   9.1805e-01   8.3704e-02   1.0045e+00   8.1502e-02
-#> 330:    1.0251e+02  -4.0998e+00  -2.3168e+00  -4.0390e+00  -1.0099e+00  -4.5752e-02   4.3120e-03   1.9810e-05   8.2684e-02   1.9770e-02   1.9049e-01   8.8495e-02   9.1779e-01   8.3731e-02   1.0046e+00   8.1500e-02
-#> 331:    1.0251e+02  -4.0998e+00  -2.3170e+00  -4.0390e+00  -1.0099e+00  -4.5957e-02   4.3052e-03   1.9736e-05   8.2748e-02   1.9734e-02   1.9034e-01   8.8651e-02   9.1818e-01   8.3707e-02   1.0050e+00   8.1489e-02
-#> 332:    1.0251e+02  -4.0998e+00  -2.3171e+00  -4.0391e+00  -1.0098e+00  -4.5788e-02   4.2994e-03   1.9733e-05   8.2906e-02   1.9711e-02   1.9035e-01   8.8647e-02   9.1835e-01   8.3660e-02   1.0052e+00   8.1490e-02
-#> 333:    1.0251e+02  -4.0998e+00  -2.3173e+00  -4.0392e+00  -1.0099e+00  -4.5316e-02   4.2822e-03   1.9667e-05   8.2967e-02   1.9695e-02   1.9041e-01   8.8729e-02   9.1832e-01   8.3666e-02   1.0056e+00   8.1484e-02
-#> 334:    1.0251e+02  -4.0998e+00  -2.3179e+00  -4.0394e+00  -1.0097e+00  -4.4740e-02   4.2668e-03   1.9593e-05   8.3055e-02   1.9702e-02   1.9058e-01   8.8853e-02   9.1799e-01   8.3687e-02   1.0056e+00   8.1457e-02
-#> 335:    1.0251e+02  -4.0998e+00  -2.3181e+00  -4.0395e+00  -1.0095e+00  -4.4451e-02   4.2558e-03   1.9535e-05   8.3023e-02   1.9762e-02   1.9027e-01   8.9035e-02   9.1828e-01   8.3673e-02   1.0052e+00   8.1469e-02
-#> 336:    1.0251e+02  -4.0998e+00  -2.3178e+00  -4.0395e+00  -1.0098e+00  -4.4500e-02   4.2571e-03   1.9546e-05   8.3051e-02   1.9779e-02   1.9024e-01   8.9486e-02   9.1868e-01   8.3611e-02   1.0053e+00   8.1515e-02
-#> 337:    1.0251e+02  -4.0998e+00  -2.3179e+00  -4.0396e+00  -1.0099e+00  -4.4018e-02   4.2494e-03   1.9584e-05   8.3206e-02   1.9764e-02   1.9011e-01   8.9643e-02   9.1871e-01   8.3659e-02   1.0056e+00   8.1531e-02
-#> 338:    1.0251e+02  -4.0998e+00  -2.3180e+00  -4.0396e+00  -1.0101e+00  -4.3768e-02   4.2332e-03   1.9635e-05   8.3235e-02   1.9751e-02   1.9011e-01   8.9877e-02   9.1939e-01   8.3622e-02   1.0060e+00   8.1528e-02
-#> 339:    1.0251e+02  -4.0998e+00  -2.3186e+00  -4.0397e+00  -1.0098e+00  -4.3605e-02   4.2237e-03   1.9638e-05   8.3611e-02   1.9725e-02   1.9014e-01   8.9946e-02   9.2025e-01   8.3580e-02   1.0064e+00   8.1528e-02
-#> 340:    1.0251e+02  -4.0998e+00  -2.3190e+00  -4.0396e+00  -1.0097e+00  -4.3585e-02   4.2095e-03   1.9630e-05   8.3986e-02   1.9677e-02   1.9019e-01   8.9920e-02   9.2124e-01   8.3559e-02   1.0073e+00   8.1516e-02
-#> 341:    1.0251e+02  -4.0998e+00  -2.3191e+00  -4.0398e+00  -1.0097e+00  -4.3238e-02   4.1994e-03   1.9636e-05   8.4311e-02   1.9683e-02   1.9023e-01   8.9809e-02   9.2179e-01   8.3517e-02   1.0079e+00   8.1498e-02
-#> 342:    1.0251e+02  -4.0998e+00  -2.3194e+00  -4.0400e+00  -1.0097e+00  -4.2748e-02   4.1886e-03   1.9661e-05   8.4345e-02   1.9684e-02   1.9018e-01   8.9600e-02   9.2207e-01   8.3517e-02   1.0081e+00   8.1517e-02
-#> 343:    1.0251e+02  -4.0998e+00  -2.3196e+00  -4.0402e+00  -1.0096e+00  -4.2336e-02   4.1813e-03   1.9615e-05   8.4331e-02   1.9666e-02   1.9016e-01   8.9379e-02   9.2231e-01   8.3534e-02   1.0083e+00   8.1548e-02
-#> 344:    1.0251e+02  -4.0998e+00  -2.3197e+00  -4.0403e+00  -1.0097e+00  -4.2462e-02   4.1751e-03   1.9621e-05   8.4176e-02   1.9673e-02   1.8996e-01   8.9217e-02   9.2236e-01   8.3540e-02   1.0083e+00   8.1557e-02
-#> 345:    1.0251e+02  -4.0998e+00  -2.3200e+00  -4.0403e+00  -1.0098e+00  -4.2327e-02   4.1705e-03   1.9552e-05   8.4159e-02   1.9684e-02   1.9017e-01   8.8957e-02   9.2232e-01   8.3511e-02   1.0085e+00   8.1566e-02
-#> 346:    1.0251e+02  -4.0998e+00  -2.3200e+00  -4.0403e+00  -1.0097e+00  -4.2261e-02   4.1750e-03   1.9564e-05   8.4080e-02   1.9731e-02   1.9047e-01   8.8630e-02   9.2248e-01   8.3516e-02   1.0081e+00   8.1578e-02
-#> 347:    1.0251e+02  -4.0999e+00  -2.3200e+00  -4.0403e+00  -1.0096e+00  -4.2296e-02   4.1883e-03   1.9634e-05   8.4231e-02   1.9747e-02   1.9061e-01   8.8399e-02   9.2250e-01   8.3557e-02   1.0075e+00   8.1580e-02
-#> 348:    1.0251e+02  -4.0999e+00  -2.3199e+00  -4.0404e+00  -1.0096e+00  -4.2345e-02   4.2129e-03   1.9692e-05   8.4295e-02   1.9719e-02   1.9068e-01   8.8210e-02   9.2212e-01   8.3568e-02   1.0075e+00   8.1586e-02
-#> 349:    1.0251e+02  -4.0999e+00  -2.3198e+00  -4.0404e+00  -1.0095e+00  -4.2617e-02   4.2066e-03   1.9720e-05   8.4289e-02   1.9731e-02   1.9054e-01   8.8147e-02   9.2185e-01   8.3565e-02   1.0070e+00   8.1590e-02
-#> 350:    1.0251e+02  -4.0999e+00  -2.3196e+00  -4.0405e+00  -1.0093e+00  -4.2582e-02   4.2011e-03   1.9760e-05   8.4302e-02   1.9703e-02   1.9044e-01   8.8068e-02   9.2182e-01   8.3537e-02   1.0070e+00   8.1590e-02
-#> 351:    1.0251e+02  -4.0998e+00  -2.3198e+00  -4.0405e+00  -1.0093e+00  -4.2377e-02   4.1970e-03   1.9750e-05   8.4587e-02   1.9708e-02   1.9045e-01   8.8008e-02   9.2169e-01   8.3507e-02   1.0067e+00   8.1584e-02
-#> 352:    1.0251e+02  -4.0998e+00  -2.3201e+00  -4.0405e+00  -1.0091e+00  -4.2159e-02   4.1973e-03   1.9819e-05   8.4804e-02   1.9678e-02   1.9040e-01   8.7894e-02   9.2113e-01   8.3528e-02   1.0061e+00   8.1554e-02
-#> 353:    1.0251e+02  -4.0998e+00  -2.3202e+00  -4.0405e+00  -1.0088e+00  -4.2123e-02   4.1968e-03   1.9855e-05   8.4945e-02   1.9634e-02   1.9049e-01   8.7941e-02   9.2108e-01   8.3500e-02   1.0058e+00   8.1548e-02
-#> 354:    1.0251e+02  -4.0998e+00  -2.3204e+00  -4.0404e+00  -1.0087e+00  -4.2217e-02   4.1918e-03   1.9909e-05   8.5122e-02   1.9565e-02   1.9055e-01   8.7948e-02   9.2088e-01   8.3523e-02   1.0059e+00   8.1530e-02
-#> 355:    1.0251e+02  -4.0998e+00  -2.3206e+00  -4.0404e+00  -1.0086e+00  -4.2057e-02   4.1853e-03   1.9973e-05   8.5389e-02   1.9505e-02   1.9057e-01   8.8109e-02   9.2100e-01   8.3496e-02   1.0058e+00   8.1520e-02
-#> 356:    1.0251e+02  -4.0998e+00  -2.3209e+00  -4.0403e+00  -1.0084e+00  -4.1880e-02   4.1796e-03   2.0058e-05   8.5446e-02   1.9451e-02   1.9063e-01   8.7944e-02   9.2086e-01   8.3483e-02   1.0061e+00   8.1488e-02
-#> 357:    1.0251e+02  -4.0998e+00  -2.3210e+00  -4.0404e+00  -1.0084e+00  -4.1565e-02   4.1858e-03   2.0131e-05   8.5481e-02   1.9391e-02   1.9072e-01   8.7879e-02   9.2119e-01   8.3465e-02   1.0066e+00   8.1468e-02
-#> 358:    1.0251e+02  -4.0998e+00  -2.3213e+00  -4.0404e+00  -1.0084e+00  -4.1497e-02   4.1826e-03   2.0168e-05   8.5661e-02   1.9361e-02   1.9086e-01   8.7635e-02   9.2095e-01   8.3475e-02   1.0069e+00   8.1445e-02
-#> 359:    1.0251e+02  -4.0997e+00  -2.3212e+00  -4.0405e+00  -1.0083e+00  -4.1127e-02   4.1993e-03   2.0188e-05   8.5904e-02   1.9347e-02   1.9078e-01   8.7558e-02   9.2087e-01   8.3451e-02   1.0068e+00   8.1461e-02
-#> 360:    1.0251e+02  -4.0997e+00  -2.3215e+00  -4.0405e+00  -1.0082e+00  -4.0919e-02   4.2006e-03   2.0173e-05   8.6133e-02   1.9333e-02   1.9071e-01   8.7479e-02   9.2061e-01   8.3439e-02   1.0067e+00   8.1453e-02
-#> 361:    1.0251e+02  -4.0997e+00  -2.3218e+00  -4.0406e+00  -1.0084e+00  -4.0317e-02   4.2013e-03   2.0253e-05   8.6558e-02   1.9351e-02   1.9075e-01   8.7309e-02   9.2060e-01   8.3425e-02   1.0069e+00   8.1464e-02
-#> 362:    1.0251e+02  -4.0997e+00  -2.3221e+00  -4.0407e+00  -1.0086e+00  -3.9991e-02   4.2004e-03   2.0305e-05   8.6952e-02   1.9369e-02   1.9077e-01   8.7106e-02   9.2037e-01   8.3462e-02   1.0072e+00   8.1464e-02
-#> 363:    1.0251e+02  -4.0997e+00  -2.3224e+00  -4.0407e+00  -1.0086e+00  -3.9745e-02   4.1920e-03   2.0350e-05   8.7210e-02   1.9373e-02   1.9095e-01   8.6967e-02   9.2025e-01   8.3462e-02   1.0070e+00   8.1489e-02
-#> 364:    1.0251e+02  -4.0997e+00  -2.3225e+00  -4.0407e+00  -1.0088e+00  -3.9585e-02   4.1826e-03   2.0355e-05   8.7449e-02   1.9353e-02   1.9099e-01   8.7119e-02   9.2081e-01   8.3468e-02   1.0070e+00   8.1514e-02
-#> 365:    1.0251e+02  -4.0997e+00  -2.3224e+00  -4.0407e+00  -1.0088e+00  -3.9531e-02   4.1781e-03   2.0298e-05   8.7646e-02   1.9346e-02   1.9083e-01   8.6997e-02   9.2106e-01   8.3455e-02   1.0068e+00   8.1546e-02
-#> 366:    1.0251e+02  -4.0997e+00  -2.3223e+00  -4.0407e+00  -1.0088e+00  -3.9436e-02   4.1805e-03   2.0301e-05   8.7772e-02   1.9354e-02   1.9074e-01   8.7057e-02   9.2118e-01   8.3426e-02   1.0064e+00   8.1555e-02
-#> 367:    1.0251e+02  -4.0997e+00  -2.3223e+00  -4.0408e+00  -1.0088e+00  -3.9172e-02   4.1791e-03   2.0368e-05   8.7914e-02   1.9333e-02   1.9063e-01   8.6948e-02   9.2106e-01   8.3409e-02   1.0060e+00   8.1558e-02
-#> 368:    1.0251e+02  -4.0997e+00  -2.3222e+00  -4.0410e+00  -1.0088e+00  -3.8640e-02   4.1857e-03   2.0343e-05   8.7937e-02   1.9334e-02   1.9051e-01   8.6857e-02   9.2143e-01   8.3379e-02   1.0058e+00   8.1564e-02
-#> 369:    1.0251e+02  -4.0997e+00  -2.3223e+00  -4.0411e+00  -1.0088e+00  -3.8331e-02   4.1862e-03   2.0309e-05   8.7933e-02   1.9319e-02   1.9046e-01   8.6689e-02   9.2126e-01   8.3410e-02   1.0053e+00   8.1559e-02
-#> 370:    1.0251e+02  -4.0997e+00  -2.3222e+00  -4.0413e+00  -1.0088e+00  -3.7984e-02   4.1921e-03   2.0301e-05   8.8082e-02   1.9313e-02   1.9050e-01   8.6622e-02   9.2101e-01   8.3424e-02   1.0049e+00   8.1559e-02
-#> 371:    1.0251e+02  -4.0998e+00  -2.3222e+00  -4.0415e+00  -1.0087e+00  -3.7729e-02   4.1972e-03   2.0277e-05   8.8271e-02   1.9308e-02   1.9035e-01   8.6655e-02   9.2092e-01   8.3426e-02   1.0046e+00   8.1575e-02
-#> 372:    1.0251e+02  -4.0998e+00  -2.3222e+00  -4.0414e+00  -1.0087e+00  -3.7571e-02   4.1922e-03   2.0292e-05   8.8651e-02   1.9317e-02   1.9025e-01   8.6528e-02   9.2126e-01   8.3440e-02   1.0046e+00   8.1576e-02
-#> 373:    1.0251e+02  -4.0998e+00  -2.3223e+00  -4.0415e+00  -1.0087e+00  -3.7327e-02   4.1971e-03   2.0343e-05   8.8865e-02   1.9290e-02   1.9002e-01   8.6437e-02   9.2122e-01   8.3475e-02   1.0044e+00   8.1571e-02
-#> 374:    1.0251e+02  -4.0998e+00  -2.3224e+00  -4.0415e+00  -1.0089e+00  -3.7275e-02   4.2072e-03   2.0450e-05   8.9078e-02   1.9306e-02   1.9002e-01   8.6224e-02   9.2111e-01   8.3480e-02   1.0047e+00   8.1569e-02
-#> 375:    1.0251e+02  -4.0998e+00  -2.3226e+00  -4.0415e+00  -1.0089e+00  -3.7080e-02   4.2062e-03   2.0489e-05   8.9178e-02   1.9320e-02   1.9016e-01   8.6141e-02   9.2116e-01   8.3483e-02   1.0047e+00   8.1586e-02
-#> 376:    1.0251e+02  -4.0998e+00  -2.3230e+00  -4.0415e+00  -1.0089e+00  -3.7043e-02   4.2105e-03   2.0517e-05   8.9291e-02   1.9325e-02   1.9018e-01   8.6033e-02   9.2114e-01   8.3474e-02   1.0046e+00   8.1572e-02
-#> 377:    1.0251e+02  -4.0998e+00  -2.3234e+00  -4.0414e+00  -1.0090e+00  -3.7302e-02   4.2097e-03   2.0524e-05   8.9438e-02   1.9333e-02   1.9012e-01   8.6018e-02   9.2123e-01   8.3476e-02   1.0046e+00   8.1545e-02
-#> 378:    1.0251e+02  -4.0998e+00  -2.3234e+00  -4.0413e+00  -1.0089e+00  -3.7617e-02   4.2161e-03   2.0520e-05   8.9567e-02   1.9305e-02   1.9012e-01   8.6106e-02   9.2115e-01   8.3444e-02   1.0049e+00   8.1534e-02
-#> 379:    1.0251e+02  -4.0998e+00  -2.3232e+00  -4.0412e+00  -1.0088e+00  -3.8039e-02   4.2231e-03   2.0484e-05   8.9704e-02   1.9276e-02   1.9015e-01   8.5914e-02   9.2060e-01   8.3438e-02   1.0048e+00   8.1532e-02
-#> 380:    1.0251e+02  -4.0998e+00  -2.3229e+00  -4.0409e+00  -1.0088e+00  -3.8613e-02   4.2221e-03   2.0452e-05   8.9751e-02   1.9293e-02   1.9018e-01   8.5907e-02   9.2032e-01   8.3428e-02   1.0045e+00   8.1545e-02
-#> 381:    1.0251e+02  -4.0998e+00  -2.3228e+00  -4.0408e+00  -1.0088e+00  -3.8992e-02   4.2177e-03   2.0475e-05   8.9641e-02   1.9314e-02   1.9014e-01   8.5978e-02   9.2015e-01   8.3429e-02   1.0040e+00   8.1535e-02
-#> 382:    1.0251e+02  -4.0998e+00  -2.3228e+00  -4.0408e+00  -1.0088e+00  -3.9393e-02   4.2092e-03   2.0508e-05   8.9624e-02   1.9352e-02   1.9010e-01   8.5929e-02   9.2037e-01   8.3422e-02   1.0037e+00   8.1535e-02
-#> 383:    1.0251e+02  -4.0998e+00  -2.3226e+00  -4.0407e+00  -1.0089e+00  -3.9650e-02   4.2080e-03   2.0503e-05   8.9621e-02   1.9349e-02   1.9000e-01   8.5735e-02   9.2021e-01   8.3436e-02   1.0038e+00   8.1544e-02
-#> 384:    1.0251e+02  -4.0998e+00  -2.3223e+00  -4.0407e+00  -1.0089e+00  -3.9709e-02   4.2111e-03   2.0489e-05   8.9690e-02   1.9347e-02   1.8985e-01   8.5516e-02   9.2025e-01   8.3420e-02   1.0037e+00   8.1541e-02
-#> 385:    1.0251e+02  -4.0998e+00  -2.3225e+00  -4.0406e+00  -1.0087e+00  -3.9762e-02   4.2130e-03   2.0458e-05   8.9795e-02   1.9380e-02   1.8978e-01   8.5306e-02   9.2055e-01   8.3405e-02   1.0034e+00   8.1518e-02
-#> 386:    1.0251e+02  -4.0998e+00  -2.3226e+00  -4.0407e+00  -1.0087e+00  -3.9801e-02   4.2117e-03   2.0473e-05   8.9838e-02   1.9386e-02   1.8986e-01   8.5045e-02   9.2034e-01   8.3388e-02   1.0036e+00   8.1512e-02
-#> 387:    1.0251e+02  -4.0998e+00  -2.3228e+00  -4.0408e+00  -1.0088e+00  -3.9548e-02   4.2221e-03   2.0474e-05   8.9914e-02   1.9399e-02   1.9001e-01   8.4840e-02   9.2080e-01   8.3373e-02   1.0037e+00   8.1503e-02
-#> 388:    1.0251e+02  -4.0998e+00  -2.3230e+00  -4.0408e+00  -1.0088e+00  -3.9408e-02   4.2272e-03   2.0464e-05   8.9977e-02   1.9383e-02   1.9000e-01   8.4644e-02   9.2070e-01   8.3377e-02   1.0034e+00   8.1494e-02
-#> 389:    1.0250e+02  -4.0998e+00  -2.3229e+00  -4.0408e+00  -1.0087e+00  -3.9326e-02   4.2285e-03   2.0459e-05   8.9927e-02   1.9366e-02   1.9001e-01   8.4485e-02   9.2063e-01   8.3367e-02   1.0032e+00   8.1487e-02
-#> 390:    1.0250e+02  -4.0998e+00  -2.3231e+00  -4.0409e+00  -1.0086e+00  -3.9130e-02   4.2286e-03   2.0423e-05   8.9894e-02   1.9331e-02   1.8996e-01   8.4434e-02   9.2054e-01   8.3339e-02   1.0032e+00   8.1481e-02
-#> 391:    1.0250e+02  -4.0998e+00  -2.3232e+00  -4.0410e+00  -1.0086e+00  -3.8976e-02   4.2242e-03   2.0419e-05   8.9782e-02   1.9299e-02   1.8992e-01   8.4344e-02   9.2089e-01   8.3320e-02   1.0032e+00   8.1480e-02
-#> 392:    1.0250e+02  -4.0998e+00  -2.3232e+00  -4.0409e+00  -1.0086e+00  -3.8856e-02   4.2179e-03   2.0396e-05   8.9773e-02   1.9263e-02   1.8984e-01   8.4469e-02   9.2084e-01   8.3309e-02   1.0034e+00   8.1489e-02
-#> 393:    1.0250e+02  -4.0998e+00  -2.3234e+00  -4.0409e+00  -1.0089e+00  -3.8820e-02   4.2135e-03   2.0375e-05   8.9746e-02   1.9259e-02   1.8972e-01   8.4731e-02   9.2088e-01   8.3310e-02   1.0031e+00   8.1481e-02
-#> 394:    1.0250e+02  -4.0998e+00  -2.3234e+00  -4.0410e+00  -1.0089e+00  -3.8759e-02   4.2123e-03   2.0382e-05   8.9791e-02   1.9271e-02   1.8958e-01   8.5075e-02   9.2064e-01   8.3316e-02   1.0028e+00   8.1483e-02
-#> 395:    1.0250e+02  -4.0998e+00  -2.3234e+00  -4.0410e+00  -1.0090e+00  -3.8565e-02   4.2179e-03   2.0420e-05   8.9844e-02   1.9279e-02   1.8948e-01   8.5286e-02   9.2070e-01   8.3311e-02   1.0027e+00   8.1499e-02
-#> 396:    1.0250e+02  -4.0998e+00  -2.3233e+00  -4.0411e+00  -1.0092e+00  -3.8505e-02   4.2207e-03   2.0445e-05   8.9863e-02   1.9281e-02   1.8944e-01   8.5452e-02   9.2053e-01   8.3326e-02   1.0028e+00   8.1524e-02
-#> 397:    1.0250e+02  -4.0998e+00  -2.3232e+00  -4.0411e+00  -1.0093e+00  -3.8366e-02   4.2115e-03   2.0410e-05   8.9792e-02   1.9287e-02   1.8938e-01   8.5649e-02   9.2063e-01   8.3351e-02   1.0034e+00   8.1519e-02
-#> 398:    1.0250e+02  -4.0998e+00  -2.3234e+00  -4.0411e+00  -1.0093e+00  -3.8179e-02   4.2049e-03   2.0362e-05   8.9718e-02   1.9281e-02   1.8943e-01   8.5813e-02   9.2065e-01   8.3391e-02   1.0040e+00   8.1513e-02
-#> 399:    1.0250e+02  -4.0998e+00  -2.3236e+00  -4.0411e+00  -1.0093e+00  -3.8020e-02   4.2015e-03   2.0320e-05   8.9743e-02   1.9283e-02   1.8934e-01   8.5899e-02   9.2056e-01   8.3426e-02   1.0045e+00   8.1500e-02
-#> 400:    1.0250e+02  -4.0998e+00  -2.3237e+00  -4.0412e+00  -1.0093e+00  -3.7796e-02   4.2017e-03   2.0296e-05   8.9684e-02   1.9297e-02   1.8932e-01   8.5849e-02   9.2107e-01   8.3413e-02   1.0051e+00   8.1502e-02
-#> 401:    1.0250e+02  -4.0998e+00  -2.3238e+00  -4.0413e+00  -1.0093e+00  -3.7697e-02   4.1959e-03   2.0275e-05   8.9618e-02   1.9291e-02   1.8914e-01   8.5796e-02   9.2086e-01   8.3480e-02   1.0051e+00   8.1510e-02
-#> 402:    1.0250e+02  -4.0998e+00  -2.3238e+00  -4.0414e+00  -1.0093e+00  -3.7639e-02   4.1863e-03   2.0273e-05   8.9522e-02   1.9285e-02   1.8898e-01   8.5723e-02   9.2041e-01   8.3534e-02   1.0053e+00   8.1520e-02
-#> 403:    1.0250e+02  -4.0998e+00  -2.3238e+00  -4.0415e+00  -1.0093e+00  -3.7634e-02   4.1878e-03   2.0250e-05   8.9456e-02   1.9288e-02   1.8895e-01   8.5791e-02   9.1990e-01   8.3549e-02   1.0055e+00   8.1545e-02
-#> 404:    1.0250e+02  -4.0999e+00  -2.3239e+00  -4.0416e+00  -1.0094e+00  -3.7581e-02   4.1854e-03   2.0292e-05   8.9326e-02   1.9326e-02   1.8902e-01   8.5928e-02   9.2016e-01   8.3542e-02   1.0053e+00   8.1565e-02
-#> 405:    1.0250e+02  -4.0999e+00  -2.3239e+00  -4.0415e+00  -1.0094e+00  -3.7740e-02   4.1804e-03   2.0333e-05   8.9304e-02   1.9334e-02   1.8892e-01   8.6225e-02   9.1978e-01   8.3559e-02   1.0052e+00   8.1588e-02
-#> 406:    1.0250e+02  -4.0999e+00  -2.3241e+00  -4.0415e+00  -1.0093e+00  -3.7837e-02   4.1866e-03   2.0375e-05   8.9281e-02   1.9322e-02   1.8906e-01   8.6421e-02   9.1972e-01   8.3556e-02   1.0051e+00   8.1596e-02
-#> 407:    1.0250e+02  -4.0999e+00  -2.3240e+00  -4.0415e+00  -1.0092e+00  -3.8211e-02   4.1948e-03   2.0335e-05   8.9117e-02   1.9303e-02   1.8913e-01   8.6644e-02   9.1975e-01   8.3592e-02   1.0052e+00   8.1594e-02
-#> 408:    1.0250e+02  -4.0999e+00  -2.3239e+00  -4.0415e+00  -1.0091e+00  -3.8144e-02   4.2081e-03   2.0320e-05   8.9057e-02   1.9287e-02   1.8912e-01   8.6825e-02   9.1992e-01   8.3572e-02   1.0054e+00   8.1577e-02
-#> 409:    1.0250e+02  -4.0999e+00  -2.3239e+00  -4.0415e+00  -1.0092e+00  -3.8261e-02   4.2186e-03   2.0295e-05   8.9007e-02   1.9339e-02   1.8923e-01   8.6869e-02   9.1991e-01   8.3568e-02   1.0053e+00   8.1578e-02
-#> 410:    1.0250e+02  -4.0999e+00  -2.3239e+00  -4.0414e+00  -1.0093e+00  -3.8478e-02   4.2150e-03   2.0311e-05   8.9089e-02   1.9427e-02   1.8939e-01   8.7036e-02   9.2050e-01   8.3537e-02   1.0051e+00   8.1581e-02
-#> 411:    1.0250e+02  -4.0999e+00  -2.3238e+00  -4.0413e+00  -1.0092e+00  -3.8732e-02   4.2116e-03   2.0289e-05   8.9015e-02   1.9467e-02   1.8939e-01   8.7005e-02   9.2025e-01   8.3538e-02   1.0049e+00   8.1581e-02
-#> 412:    1.0250e+02  -4.0999e+00  -2.3238e+00  -4.0413e+00  -1.0092e+00  -3.8793e-02   4.2085e-03   2.0295e-05   8.9020e-02   1.9477e-02   1.8946e-01   8.7080e-02   9.2047e-01   8.3532e-02   1.0049e+00   8.1575e-02
-#> 413:    1.0250e+02  -4.0999e+00  -2.3236e+00  -4.0412e+00  -1.0093e+00  -3.8937e-02   4.2069e-03   2.0288e-05   8.9121e-02   1.9495e-02   1.8939e-01   8.7203e-02   9.2043e-01   8.3528e-02   1.0046e+00   8.1581e-02
-#> 414:    1.0250e+02  -4.0999e+00  -2.3233e+00  -4.0412e+00  -1.0093e+00  -3.9068e-02   4.2065e-03   2.0272e-05   8.9126e-02   1.9508e-02   1.8939e-01   8.7485e-02   9.2038e-01   8.3517e-02   1.0046e+00   8.1589e-02
-#> 415:    1.0250e+02  -4.0999e+00  -2.3234e+00  -4.0412e+00  -1.0092e+00  -3.9299e-02   4.2117e-03   2.0277e-05   8.8971e-02   1.9564e-02   1.8955e-01   8.7734e-02   9.2051e-01   8.3502e-02   1.0048e+00   8.1575e-02
-#> 416:    1.0250e+02  -4.0999e+00  -2.3232e+00  -4.0413e+00  -1.0092e+00  -3.9575e-02   4.2122e-03   2.0269e-05   8.8909e-02   1.9609e-02   1.8954e-01   8.7910e-02   9.2061e-01   8.3488e-02   1.0045e+00   8.1561e-02
-#> 417:    1.0250e+02  -4.0999e+00  -2.3228e+00  -4.0412e+00  -1.0092e+00  -3.9794e-02   4.2133e-03   2.0289e-05   8.8845e-02   1.9606e-02   1.8949e-01   8.8036e-02   9.2065e-01   8.3481e-02   1.0047e+00   8.1558e-02
-#> 418:    1.0250e+02  -4.0999e+00  -2.3226e+00  -4.0412e+00  -1.0092e+00  -4.0019e-02   4.2209e-03   2.0279e-05   8.8864e-02   1.9618e-02   1.8939e-01   8.8094e-02   9.2062e-01   8.3490e-02   1.0044e+00   8.1566e-02
-#> 419:    1.0250e+02  -4.0999e+00  -2.3225e+00  -4.0411e+00  -1.0092e+00  -4.0090e-02   4.2242e-03   2.0258e-05   8.9089e-02   1.9644e-02   1.8924e-01   8.8285e-02   9.2082e-01   8.3484e-02   1.0040e+00   8.1567e-02
-#> 420:    1.0250e+02  -4.0999e+00  -2.3223e+00  -4.0410e+00  -1.0091e+00  -4.0260e-02   4.2298e-03   2.0249e-05   8.9215e-02   1.9640e-02   1.8919e-01   8.8683e-02   9.2127e-01   8.3454e-02   1.0041e+00   8.1564e-02
-#> 421:    1.0250e+02  -4.0998e+00  -2.3222e+00  -4.0410e+00  -1.0090e+00  -4.0359e-02   4.2292e-03   2.0289e-05   8.9366e-02   1.9642e-02   1.8928e-01   8.8905e-02   9.2154e-01   8.3452e-02   1.0038e+00   8.1572e-02
-#> 422:    1.0250e+02  -4.0998e+00  -2.3223e+00  -4.0410e+00  -1.0088e+00  -4.0380e-02   4.2311e-03   2.0289e-05   8.9318e-02   1.9636e-02   1.8934e-01   8.9025e-02   9.2137e-01   8.3486e-02   1.0039e+00   8.1562e-02
-#> 423:    1.0250e+02  -4.0998e+00  -2.3224e+00  -4.0411e+00  -1.0088e+00  -4.0256e-02   4.2283e-03   2.0277e-05   8.9324e-02   1.9645e-02   1.8923e-01   8.9305e-02   9.2129e-01   8.3484e-02   1.0038e+00   8.1565e-02
-#> 424:    1.0250e+02  -4.0998e+00  -2.3226e+00  -4.0412e+00  -1.0088e+00  -4.0075e-02   4.2333e-03   2.0245e-05   8.9193e-02   1.9657e-02   1.8914e-01   8.9480e-02   9.2122e-01   8.3487e-02   1.0039e+00   8.1587e-02
-#> 425:    1.0250e+02  -4.0998e+00  -2.3226e+00  -4.0413e+00  -1.0088e+00  -3.9950e-02   4.2360e-03   2.0257e-05   8.9170e-02   1.9644e-02   1.8924e-01   8.9622e-02   9.2104e-01   8.3492e-02   1.0042e+00   8.1599e-02
-#> 426:    1.0250e+02  -4.0998e+00  -2.3226e+00  -4.0413e+00  -1.0088e+00  -3.9789e-02   4.2376e-03   2.0245e-05   8.9143e-02   1.9654e-02   1.8917e-01   8.9791e-02   9.2100e-01   8.3514e-02   1.0039e+00   8.1607e-02
-#> 427:    1.0250e+02  -4.0998e+00  -2.3224e+00  -4.0414e+00  -1.0087e+00  -3.9766e-02   4.2469e-03   2.0228e-05   8.9102e-02   1.9656e-02   1.8913e-01   9.0076e-02   9.2110e-01   8.3499e-02   1.0037e+00   8.1607e-02
-#> 428:    1.0250e+02  -4.0998e+00  -2.3225e+00  -4.0414e+00  -1.0088e+00  -3.9662e-02   4.2522e-03   2.0205e-05   8.9151e-02   1.9669e-02   1.8912e-01   9.0312e-02   9.2102e-01   8.3483e-02   1.0036e+00   8.1599e-02
-#> 429:    1.0250e+02  -4.0998e+00  -2.3225e+00  -4.0414e+00  -1.0089e+00  -3.9547e-02   4.2615e-03   2.0187e-05   8.9103e-02   1.9681e-02   1.8907e-01   9.0576e-02   9.2082e-01   8.3488e-02   1.0035e+00   8.1592e-02
-#> 430:    1.0250e+02  -4.0998e+00  -2.3224e+00  -4.0414e+00  -1.0088e+00  -3.9593e-02   4.2613e-03   2.0159e-05   8.9075e-02   1.9692e-02   1.8894e-01   9.0762e-02   9.2073e-01   8.3487e-02   1.0035e+00   8.1603e-02
-#> 431:    1.0250e+02  -4.0998e+00  -2.3223e+00  -4.0413e+00  -1.0088e+00  -3.9929e-02   4.2668e-03   2.0112e-05   8.8982e-02   1.9682e-02   1.8901e-01   9.0997e-02   9.2043e-01   8.3487e-02   1.0036e+00   8.1604e-02
-#> 432:    1.0250e+02  -4.0998e+00  -2.3223e+00  -4.0413e+00  -1.0088e+00  -4.0182e-02   4.2693e-03   2.0089e-05   8.8860e-02   1.9659e-02   1.8898e-01   9.1110e-02   9.2024e-01   8.3490e-02   1.0036e+00   8.1585e-02
-#> 433:    1.0250e+02  -4.0998e+00  -2.3222e+00  -4.0412e+00  -1.0088e+00  -4.0415e-02   4.2706e-03   2.0081e-05   8.8670e-02   1.9650e-02   1.8899e-01   9.1199e-02   9.1999e-01   8.3485e-02   1.0036e+00   8.1587e-02
-#> 434:    1.0250e+02  -4.0998e+00  -2.3220e+00  -4.0412e+00  -1.0087e+00  -4.0405e-02   4.2661e-03   2.0060e-05   8.8576e-02   1.9667e-02   1.8897e-01   9.1180e-02   9.1998e-01   8.3468e-02   1.0034e+00   8.1594e-02
-#> 435:    1.0250e+02  -4.0998e+00  -2.3218e+00  -4.0413e+00  -1.0087e+00  -4.0471e-02   4.2639e-03   2.0050e-05   8.8450e-02   1.9671e-02   1.8891e-01   9.1156e-02   9.1970e-01   8.3469e-02   1.0033e+00   8.1602e-02
-#> 436:    1.0250e+02  -4.0998e+00  -2.3216e+00  -4.0413e+00  -1.0086e+00  -4.0478e-02   4.2614e-03   2.0025e-05   8.8470e-02   1.9677e-02   1.8892e-01   9.1234e-02   9.1948e-01   8.3484e-02   1.0033e+00   8.1608e-02
-#> 437:    1.0250e+02  -4.0998e+00  -2.3214e+00  -4.0413e+00  -1.0086e+00  -4.0648e-02   4.2569e-03   2.0021e-05   8.8378e-02   1.9694e-02   1.8896e-01   9.1289e-02   9.1946e-01   8.3486e-02   1.0034e+00   8.1608e-02
-#> 438:    1.0250e+02  -4.0998e+00  -2.3214e+00  -4.0413e+00  -1.0085e+00  -4.0807e-02   4.2559e-03   2.0029e-05   8.8244e-02   1.9704e-02   1.8898e-01   9.1352e-02   9.1920e-01   8.3494e-02   1.0034e+00   8.1604e-02
-#> 439:    1.0250e+02  -4.0998e+00  -2.3215e+00  -4.0413e+00  -1.0084e+00  -4.0814e-02   4.2472e-03   2.0035e-05   8.8064e-02   1.9736e-02   1.8905e-01   9.1469e-02   9.1900e-01   8.3510e-02   1.0032e+00   8.1602e-02
-#> 440:    1.0250e+02  -4.0998e+00  -2.3216e+00  -4.0414e+00  -1.0084e+00  -4.0845e-02   4.2385e-03   2.0044e-05   8.7953e-02   1.9775e-02   1.8906e-01   9.1482e-02   9.1902e-01   8.3529e-02   1.0029e+00   8.1605e-02
-#> 441:    1.0250e+02  -4.0998e+00  -2.3218e+00  -4.0415e+00  -1.0084e+00  -4.0561e-02   4.2293e-03   2.0096e-05   8.7978e-02   1.9848e-02   1.8914e-01   9.1431e-02   9.1890e-01   8.3545e-02   1.0026e+00   8.1618e-02
-#> 442:    1.0250e+02  -4.0998e+00  -2.3219e+00  -4.0415e+00  -1.0085e+00  -4.0297e-02   4.2190e-03   2.0140e-05   8.8016e-02   1.9884e-02   1.8912e-01   9.1373e-02   9.1910e-01   8.3556e-02   1.0025e+00   8.1632e-02
-#> 443:    1.0250e+02  -4.0998e+00  -2.3222e+00  -4.0415e+00  -1.0086e+00  -4.0124e-02   4.2172e-03   2.0182e-05   8.8183e-02   1.9921e-02   1.8920e-01   9.1354e-02   9.1928e-01   8.3555e-02   1.0023e+00   8.1646e-02
-#> 444:    1.0250e+02  -4.0999e+00  -2.3223e+00  -4.0416e+00  -1.0084e+00  -4.0120e-02   4.2226e-03   2.0208e-05   8.8142e-02   1.9980e-02   1.8916e-01   9.1269e-02   9.1934e-01   8.3540e-02   1.0020e+00   8.1653e-02
-#> 445:    1.0250e+02  -4.0999e+00  -2.3223e+00  -4.0416e+00  -1.0083e+00  -4.0180e-02   4.2279e-03   2.0283e-05   8.8188e-02   2.0009e-02   1.8925e-01   9.1096e-02   9.1924e-01   8.3538e-02   1.0017e+00   8.1644e-02
-#> 446:    1.0250e+02  -4.0999e+00  -2.3223e+00  -4.0417e+00  -1.0084e+00  -4.0083e-02   4.2373e-03   2.0357e-05   8.8255e-02   2.0030e-02   1.8937e-01   9.0921e-02   9.1921e-01   8.3535e-02   1.0015e+00   8.1652e-02
-#> 447:    1.0250e+02  -4.0999e+00  -2.3223e+00  -4.0417e+00  -1.0083e+00  -4.0032e-02   4.2591e-03   2.0418e-05   8.8322e-02   2.0055e-02   1.8931e-01   9.0741e-02   9.1928e-01   8.3527e-02   1.0011e+00   8.1662e-02
-#> 448:    1.0250e+02  -4.0999e+00  -2.3224e+00  -4.0417e+00  -1.0083e+00  -4.0042e-02   4.2759e-03   2.0499e-05   8.8372e-02   2.0083e-02   1.8935e-01   9.0554e-02   9.1942e-01   8.3524e-02   1.0010e+00   8.1661e-02
-#> 449:    1.0250e+02  -4.0999e+00  -2.3224e+00  -4.0417e+00  -1.0083e+00  -4.0219e-02   4.2779e-03   2.0525e-05   8.8377e-02   2.0104e-02   1.8937e-01   9.0424e-02   9.1970e-01   8.3510e-02   1.0009e+00   8.1654e-02
-#> 450:    1.0250e+02  -4.0999e+00  -2.3223e+00  -4.0416e+00  -1.0084e+00  -4.0390e-02   4.2779e-03   2.0520e-05   8.8387e-02   2.0120e-02   1.8939e-01   9.0277e-02   9.1991e-01   8.3489e-02   1.0010e+00   8.1662e-02
-#> 451:    1.0250e+02  -4.0999e+00  -2.3221e+00  -4.0415e+00  -1.0085e+00  -4.0403e-02   4.2785e-03   2.0554e-05   8.8442e-02   2.0130e-02   1.8934e-01   9.0032e-02   9.2001e-01   8.3485e-02   1.0011e+00   8.1676e-02
-#> 452:    1.0250e+02  -4.0999e+00  -2.3220e+00  -4.0415e+00  -1.0084e+00  -4.0503e-02   4.2730e-03   2.0537e-05   8.8507e-02   2.0135e-02   1.8926e-01   8.9777e-02   9.2031e-01   8.3473e-02   1.0013e+00   8.1671e-02
-#> 453:    1.0250e+02  -4.0999e+00  -2.3221e+00  -4.0415e+00  -1.0084e+00  -4.0716e-02   4.2650e-03   2.0525e-05   8.8565e-02   2.0168e-02   1.8921e-01   8.9653e-02   9.2030e-01   8.3473e-02   1.0010e+00   8.1665e-02
-#> 454:    1.0250e+02  -4.0999e+00  -2.3221e+00  -4.0415e+00  -1.0083e+00  -4.0900e-02   4.2583e-03   2.0505e-05   8.8572e-02   2.0194e-02   1.8912e-01   8.9524e-02   9.2039e-01   8.3457e-02   1.0009e+00   8.1658e-02
-#> 455:    1.0250e+02  -4.0999e+00  -2.3220e+00  -4.0415e+00  -1.0083e+00  -4.0930e-02   4.2524e-03   2.0495e-05   8.8643e-02   2.0246e-02   1.8914e-01   8.9416e-02   9.2035e-01   8.3454e-02   1.0006e+00   8.1655e-02
-#> 456:    1.0250e+02  -4.0999e+00  -2.3218e+00  -4.0414e+00  -1.0084e+00  -4.1008e-02   4.2455e-03   2.0482e-05   8.8831e-02   2.0290e-02   1.8904e-01   8.9438e-02   9.2042e-01   8.3448e-02   1.0005e+00   8.1672e-02
-#> 457:    1.0250e+02  -4.0999e+00  -2.3216e+00  -4.0414e+00  -1.0085e+00  -4.1073e-02   4.2376e-03   2.0479e-05   8.8831e-02   2.0310e-02   1.8893e-01   8.9411e-02   9.2049e-01   8.3438e-02   1.0005e+00   8.1677e-02
-#> 458:    1.0250e+02  -4.0999e+00  -2.3215e+00  -4.0414e+00  -1.0085e+00  -4.1036e-02   4.2288e-03   2.0479e-05   8.8894e-02   2.0311e-02   1.8879e-01   8.9378e-02   9.2055e-01   8.3419e-02   1.0006e+00   8.1689e-02
-#> 459:    1.0250e+02  -4.0999e+00  -2.3216e+00  -4.0414e+00  -1.0085e+00  -4.1084e-02   4.2296e-03   2.0472e-05   8.8976e-02   2.0290e-02   1.8876e-01   8.9365e-02   9.2056e-01   8.3404e-02   1.0007e+00   8.1678e-02
-#> 460:    1.0250e+02  -4.0999e+00  -2.3215e+00  -4.0414e+00  -1.0084e+00  -4.1065e-02   4.2257e-03   2.0473e-05   8.8978e-02   2.0254e-02   1.8871e-01   8.9287e-02   9.2061e-01   8.3386e-02   1.0007e+00   8.1663e-02
-#> 461:    1.0250e+02  -4.0999e+00  -2.3213e+00  -4.0414e+00  -1.0084e+00  -4.1142e-02   4.2254e-03   2.0441e-05   8.8952e-02   2.0238e-02   1.8864e-01   8.9236e-02   9.2067e-01   8.3359e-02   1.0007e+00   8.1670e-02
-#> 462:    1.0250e+02  -4.0999e+00  -2.3213e+00  -4.0413e+00  -1.0083e+00  -4.1199e-02   4.2230e-03   2.0409e-05   8.9161e-02   2.0235e-02   1.8852e-01   8.9179e-02   9.2070e-01   8.3339e-02   1.0005e+00   8.1686e-02
-#> 463:    1.0250e+02  -4.0999e+00  -2.3214e+00  -4.0413e+00  -1.0084e+00  -4.1131e-02   4.2191e-03   2.0397e-05   8.9356e-02   2.0251e-02   1.8850e-01   8.9138e-02   9.2098e-01   8.3308e-02   1.0003e+00   8.1688e-02
-#> 464:    1.0250e+02  -4.0999e+00  -2.3213e+00  -4.0414e+00  -1.0084e+00  -4.0937e-02   4.2187e-03   2.0395e-05   8.9553e-02   2.0237e-02   1.8848e-01   8.9097e-02   9.2108e-01   8.3293e-02   1.0001e+00   8.1684e-02
-#> 465:    1.0250e+02  -4.0999e+00  -2.3213e+00  -4.0414e+00  -1.0086e+00  -4.0873e-02   4.2226e-03   2.0374e-05   8.9675e-02   2.0210e-02   1.8854e-01   8.9045e-02   9.2115e-01   8.3282e-02   1.0002e+00   8.1678e-02
-#> 466:    1.0250e+02  -4.0999e+00  -2.3213e+00  -4.0414e+00  -1.0085e+00  -4.1046e-02   4.2312e-03   2.0379e-05   8.9703e-02   2.0232e-02   1.8852e-01   8.9031e-02   9.2100e-01   8.3294e-02   9.9982e-01   8.1665e-02
-#> 467:    1.0250e+02  -4.0999e+00  -2.3214e+00  -4.0414e+00  -1.0086e+00  -4.1081e-02   4.2382e-03   2.0421e-05   8.9802e-02   2.0266e-02   1.8851e-01   8.9175e-02   9.2124e-01   8.3271e-02   9.9943e-01   8.1671e-02
-#> 468:    1.0250e+02  -4.0999e+00  -2.3215e+00  -4.0414e+00  -1.0085e+00  -4.1107e-02   4.2412e-03   2.0446e-05   8.9937e-02   2.0281e-02   1.8857e-01   8.9238e-02   9.2125e-01   8.3255e-02   9.9912e-01   8.1659e-02
-#> 469:    1.0250e+02  -4.0999e+00  -2.3214e+00  -4.0414e+00  -1.0084e+00  -4.1269e-02   4.2380e-03   2.0449e-05   8.9938e-02   2.0285e-02   1.8867e-01   8.9378e-02   9.2144e-01   8.3225e-02   9.9906e-01   8.1651e-02
-#> 470:    1.0250e+02  -4.0999e+00  -2.3212e+00  -4.0413e+00  -1.0083e+00  -4.1552e-02   4.2384e-03   2.0437e-05   8.9924e-02   2.0280e-02   1.8878e-01   8.9520e-02   9.2149e-01   8.3205e-02   9.9880e-01   8.1648e-02
-#> 471:    1.0250e+02  -4.0999e+00  -2.3210e+00  -4.0412e+00  -1.0082e+00  -4.2096e-02   4.2375e-03   2.0433e-05   8.9875e-02   2.0267e-02   1.8880e-01   8.9608e-02   9.2149e-01   8.3221e-02   9.9869e-01   8.1642e-02
-#> 472:    1.0250e+02  -4.0999e+00  -2.3210e+00  -4.0411e+00  -1.0081e+00  -4.2380e-02   4.2446e-03   2.0435e-05   8.9823e-02   2.0262e-02   1.8885e-01   8.9602e-02   9.2156e-01   8.3233e-02   9.9868e-01   8.1643e-02
-#> 473:    1.0250e+02  -4.0999e+00  -2.3210e+00  -4.0410e+00  -1.0080e+00  -4.2522e-02   4.2486e-03   2.0429e-05   8.9793e-02   2.0231e-02   1.8877e-01   8.9608e-02   9.2177e-01   8.3210e-02   9.9901e-01   8.1637e-02
-#> 474:    1.0250e+02  -4.0999e+00  -2.3209e+00  -4.0410e+00  -1.0079e+00  -4.2640e-02   4.2536e-03   2.0403e-05   8.9731e-02   2.0213e-02   1.8876e-01   8.9632e-02   9.2177e-01   8.3192e-02   9.9942e-01   8.1632e-02
-#> 475:    1.0250e+02  -4.0999e+00  -2.3208e+00  -4.0409e+00  -1.0079e+00  -4.2882e-02   4.2576e-03   2.0375e-05   8.9666e-02   2.0190e-02   1.8866e-01   8.9718e-02   9.2160e-01   8.3218e-02   9.9931e-01   8.1622e-02
-#> 476:    1.0250e+02  -4.0999e+00  -2.3207e+00  -4.0409e+00  -1.0080e+00  -4.2983e-02   4.2599e-03   2.0368e-05   8.9563e-02   2.0171e-02   1.8859e-01   8.9777e-02   9.2162e-01   8.3236e-02   9.9932e-01   8.1620e-02
-#> 477:    1.0250e+02  -4.0999e+00  -2.3205e+00  -4.0410e+00  -1.0081e+00  -4.3022e-02   4.2570e-03   2.0364e-05   8.9440e-02   2.0166e-02   1.8860e-01   8.9785e-02   9.2171e-01   8.3236e-02   9.9940e-01   8.1633e-02
-#> 478:    1.0250e+02  -4.0999e+00  -2.3203e+00  -4.0410e+00  -1.0080e+00  -4.3129e-02   4.2505e-03   2.0371e-05   8.9374e-02   2.0151e-02   1.8859e-01   8.9826e-02   9.2171e-01   8.3224e-02   9.9970e-01   8.1620e-02
-#> 479:    1.0250e+02  -4.1000e+00  -2.3201e+00  -4.0410e+00  -1.0080e+00  -4.3186e-02   4.2440e-03   2.0373e-05   8.9355e-02   2.0133e-02   1.8858e-01   8.9837e-02   9.2168e-01   8.3214e-02   9.9991e-01   8.1621e-02
-#> 480:    1.0250e+02  -4.1000e+00  -2.3198e+00  -4.0410e+00  -1.0080e+00  -4.3477e-02   4.2424e-03   2.0440e-05   8.9311e-02   2.0121e-02   1.8857e-01   8.9848e-02   9.2158e-01   8.3221e-02   9.9995e-01   8.1627e-02
-#> 481:    1.0250e+02  -4.1000e+00  -2.3194e+00  -4.0410e+00  -1.0079e+00  -4.3647e-02   4.2358e-03   2.0479e-05   8.9315e-02   2.0096e-02   1.8851e-01   8.9865e-02   9.2159e-01   8.3197e-02   1.0002e+00   8.1642e-02
-#> 482:    1.0250e+02  -4.1000e+00  -2.3188e+00  -4.0409e+00  -1.0079e+00  -4.3909e-02   4.2370e-03   2.0551e-05   8.9382e-02   2.0085e-02   1.8840e-01   8.9799e-02   9.2147e-01   8.3229e-02   1.0001e+00   8.1656e-02
-#> 483:    1.0250e+02  -4.1000e+00  -2.3189e+00  -4.0409e+00  -1.0078e+00  -4.4169e-02   4.2467e-03   2.0587e-05   8.9377e-02   2.0054e-02   1.8838e-01   8.9943e-02   9.2130e-01   8.3237e-02   1.0003e+00   8.1650e-02
-#> 484:    1.0250e+02  -4.1000e+00  -2.3188e+00  -4.0408e+00  -1.0078e+00  -4.4346e-02   4.2627e-03   2.0605e-05   8.9450e-02   2.0020e-02   1.8840e-01   9.0090e-02   9.2114e-01   8.3237e-02   1.0004e+00   8.1639e-02
-#> 485:    1.0250e+02  -4.1000e+00  -2.3185e+00  -4.0408e+00  -1.0079e+00  -4.4414e-02   4.2737e-03   2.0594e-05   8.9541e-02   1.9999e-02   1.8842e-01   9.0237e-02   9.2116e-01   8.3227e-02   1.0004e+00   8.1641e-02
-#> 486:    1.0250e+02  -4.1000e+00  -2.3183e+00  -4.0408e+00  -1.0080e+00  -4.4572e-02   4.2902e-03   2.0581e-05   8.9733e-02   1.9978e-02   1.8837e-01   9.0412e-02   9.2098e-01   8.3224e-02   1.0003e+00   8.1642e-02
-#> 487:    1.0250e+02  -4.1000e+00  -2.3182e+00  -4.0407e+00  -1.0081e+00  -4.4698e-02   4.2979e-03   2.0560e-05   8.9822e-02   1.9954e-02   1.8827e-01   9.0744e-02   9.2114e-01   8.3212e-02   1.0003e+00   8.1644e-02
-#> 488:    1.0250e+02  -4.1000e+00  -2.3180e+00  -4.0406e+00  -1.0081e+00  -4.4892e-02   4.3035e-03   2.0549e-05   8.9849e-02   1.9928e-02   1.8816e-01   9.1000e-02   9.2118e-01   8.3206e-02   1.0003e+00   8.1644e-02
-#> 489:    1.0250e+02  -4.1000e+00  -2.3180e+00  -4.0406e+00  -1.0081e+00  -4.5037e-02   4.2987e-03   2.0515e-05   8.9843e-02   1.9906e-02   1.8815e-01   9.1260e-02   9.2116e-01   8.3190e-02   1.0001e+00   8.1633e-02
-#> 490:    1.0250e+02  -4.1000e+00  -2.3179e+00  -4.0405e+00  -1.0081e+00  -4.5139e-02   4.2930e-03   2.0508e-05   8.9827e-02   1.9887e-02   1.8814e-01   9.1545e-02   9.2114e-01   8.3178e-02   9.9991e-01   8.1624e-02
-#> 491:    1.0250e+02  -4.1000e+00  -2.3179e+00  -4.0405e+00  -1.0081e+00  -4.5107e-02   4.2871e-03   2.0490e-05   8.9765e-02   1.9855e-02   1.8814e-01   9.1702e-02   9.2089e-01   8.3179e-02   9.9986e-01   8.1624e-02
-#> 492:    1.0250e+02  -4.1000e+00  -2.3178e+00  -4.0405e+00  -1.0080e+00  -4.5192e-02   4.2818e-03   2.0470e-05   8.9791e-02   1.9831e-02   1.8810e-01   9.1846e-02   9.2086e-01   8.3164e-02   9.9977e-01   8.1630e-02
-#> 493:    1.0250e+02  -4.1000e+00  -2.3179e+00  -4.0406e+00  -1.0078e+00  -4.4968e-02   4.2782e-03   2.0452e-05   8.9797e-02   1.9804e-02   1.8806e-01   9.1987e-02   9.2080e-01   8.3146e-02   9.9982e-01   8.1627e-02
-#> 494:    1.0250e+02  -4.1000e+00  -2.3180e+00  -4.0406e+00  -1.0078e+00  -4.4773e-02   4.2766e-03   2.0453e-05   8.9696e-02   1.9781e-02   1.8805e-01   9.2096e-02   9.2057e-01   8.3148e-02   9.9999e-01   8.1611e-02
-#> 495:    1.0250e+02  -4.1000e+00  -2.3181e+00  -4.0408e+00  -1.0078e+00  -4.4647e-02   4.2798e-03   2.0446e-05   8.9661e-02   1.9763e-02   1.8804e-01   9.2155e-02   9.2039e-01   8.3137e-02   9.9999e-01   8.1599e-02
-#> 496:    1.0250e+02  -4.1000e+00  -2.3182e+00  -4.0408e+00  -1.0079e+00  -4.4482e-02   4.2851e-03   2.0434e-05   8.9630e-02   1.9750e-02   1.8796e-01   9.2258e-02   9.2042e-01   8.3124e-02   1.0000e+00   8.1601e-02
-#> 497:    1.0250e+02  -4.1000e+00  -2.3184e+00  -4.0409e+00  -1.0079e+00  -4.4175e-02   4.2866e-03   2.0423e-05   8.9656e-02   1.9743e-02   1.8789e-01   9.2225e-02   9.2017e-01   8.3126e-02   1.0002e+00   8.1616e-02
-#> 498:    1.0250e+02  -4.1000e+00  -2.3187e+00  -4.0409e+00  -1.0079e+00  -4.3826e-02   4.2847e-03   2.0406e-05   8.9587e-02   1.9730e-02   1.8781e-01   9.2143e-02   9.2017e-01   8.3156e-02   1.0002e+00   8.1613e-02
-#> 499:    1.0250e+02  -4.1000e+00  -2.3190e+00  -4.0409e+00  -1.0078e+00  -4.3529e-02   4.2806e-03   2.0397e-05   8.9653e-02   1.9712e-02   1.8779e-01   9.2107e-02   9.2028e-01   8.3172e-02   1.0004e+00   8.1607e-02
-#> 500:    1.0250e+02  -4.1000e+00  -2.3193e+00  -4.0409e+00  -1.0077e+00  -4.3241e-02   4.2787e-03   2.0390e-05   8.9759e-02   1.9689e-02   1.8773e-01   9.2021e-02   9.2029e-01   8.3203e-02   1.0006e+00   8.1613e-02
-#> Calculating covariance matrix
-#> 
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Calculating residuals/tables
-#> done
-# The following takes a very long time but gives
-f_nlmixr_dfop_sfo_focei <- nlmixr(f_mmkin_dfop_sfo, est = "focei")
-#> ℹ parameter labels from comments are typically ignored in non-interactive mode
-#> ℹ Need to run with the source intact to parse comments
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → creating full model...
-#> → pruning branches (`if`/`else`)...
-#> ✔ done
-#> → loading into symengine environment...
-#> ✔ done
-#> → calculate jacobian
-#> 
-#> → calculate sensitivities
-#> 
-#> → calculate ∂(f)/∂(η)
-#> 
-#> → calculate ∂(R²)/∂(η)
-#> 
-#> → finding duplicate expressions in inner model...
-#> 
-#> → optimizing duplicate expressions in inner model...
-#> 
-#> → finding duplicate expressions in EBE model...
-#> 
-#> → optimizing duplicate expressions in EBE model...
-#> 
-#> → compiling inner model...
-#>  
-#> ✔ done
-#> → finding duplicate expressions in FD model...
-#> 
-#> → optimizing duplicate expressions in FD model...
-#> 
-#> → compiling EBE model...
-#>  
-#> ✔ done
-#> → compiling events FD model...
-#>  
-#> ✔ done
-#> Needed Covariates:
-#> [1] "CMT"
-#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
-#> F: Forward difference gradient approximation
-#> C: Central difference gradient approximation
-#> M: Mixed forward and central difference gradient approximation
-#> Unscaled parameters for Omegas=chol(solve(omega));
-#> Diagonals are transformed, as specified by foceiControl(diagXform=)
-#> |-----+---------------+-----------+-----------+-----------+-----------|
-#> |    #| Objective Fun |  parent_0 |  log_k_m1 |f_parent_qlogis |    log_k1 |
-#> |.....................|    log_k2 |  g_qlogis | sigma_low |  rsd_high |
-#> |.....................|        o1 |        o2 |        o3 |        o4 |
-#> |.....................|        o5 |        o6 |...........|...........|
-#> |    1|     496.69520 |     1.000 |    -1.000 |   -0.9393 |   -0.9673 |
-#> |.....................|    -1.000 |   -0.9214 |   -0.9072 |   -0.9199 |
-#> |.....................|   -0.9082 |   -0.8909 |   -0.8969 |   -0.8991 |
-#> |.....................|   -0.8928 |   -0.8991 |...........|...........|
-#> |    U|      496.6952 |     100.0 |    -4.100 |   -0.9400 |    -2.400 |
-#> |.....................|    -4.100 |  -0.01100 |    0.7300 |   0.06700 |
-#> |.....................|    0.6756 |     1.581 |     1.265 |     1.151 |
-#> |.....................|     1.477 |     1.151 |...........|...........|
-#> |    X|      496.6952 |     100.0 |   0.01657 |    0.2809 |   0.09072 |
-#> |.....................|   0.01657 |    0.4973 |    0.7300 |   0.06700 |
-#> |.....................|    0.6756 |     1.581 |     1.265 |     1.151 |
-#> |.....................|     1.477 |     1.151 |...........|...........|
-#> |    G|    Gill Diff. |    -72.99 |    -3.907 |   -0.8109 |   0.02803 |
-#> |.....................|    -1.841 |  0.006841 |    -22.18 |    -32.78 |
-#> |.....................|     3.538 |    -16.93 |    -12.84 |    -12.77 |
-#> |.....................|    -15.02 |    -9.608 |...........|...........|
-#> |    2|     1346.5436 |     1.823 |   -0.9559 |   -0.9301 |   -0.9677 |
-#> |.....................|   -0.9792 |   -0.9215 |   -0.6570 |   -0.5501 |
-#> |.....................|   -0.9482 |   -0.6999 |   -0.7521 |   -0.7551 |
-#> |.....................|   -0.7234 |   -0.7907 |...........|...........|
-#> |    U|     1346.5436 |     182.3 |    -4.056 |   -0.9314 |    -2.400 |
-#> |.....................|    -4.079 |  -0.01100 |    0.8213 |   0.07939 |
-#> |.....................|    0.6486 |     1.883 |     1.449 |     1.317 |
-#> |.....................|     1.728 |     1.276 |...........|...........|
-#> |    X|     1346.5436 |     182.3 |   0.01732 |    0.2826 |   0.09069 |
-#> |.....................|   0.01692 |    0.4972 |    0.8213 |   0.07939 |
-#> |.....................|    0.6486 |     1.883 |     1.449 |     1.317 |
-#> |.....................|     1.728 |     1.276 |...........|...........|
-#> |    3|     512.48246 |     1.082 |   -0.9956 |   -0.9384 |   -0.9674 |
-#> |.....................|   -0.9979 |   -0.9214 |   -0.8822 |   -0.8830 |
-#> |.....................|   -0.9122 |   -0.8718 |   -0.8824 |   -0.8847 |
-#> |.....................|   -0.8759 |   -0.8883 |...........|...........|
-#> |    U|     512.48246 |     108.2 |    -4.096 |   -0.9391 |    -2.400 |
-#> |.....................|    -4.098 |  -0.01100 |    0.7391 |   0.06824 |
-#> |.....................|    0.6729 |     1.611 |     1.284 |     1.167 |
-#> |.....................|     1.502 |     1.163 |...........|...........|
-#> |    X|     512.48246 |     108.2 |   0.01665 |    0.2811 |   0.09072 |
-#> |.....................|   0.01661 |    0.4973 |    0.7391 |   0.06824 |
-#> |.....................|    0.6729 |     1.611 |     1.284 |     1.167 |
-#> |.....................|     1.502 |     1.163 |...........|...........|
-#> |    4|     495.95762 |     1.015 |   -0.9992 |   -0.9391 |   -0.9673 |
-#> |.....................|   -0.9996 |   -0.9214 |   -0.9027 |   -0.9133 |
-#> |.....................|   -0.9090 |   -0.8874 |   -0.8943 |   -0.8965 |
-#> |.....................|   -0.8898 |   -0.8972 |...........|...........|
-#> |    U|     495.95762 |     101.5 |    -4.099 |   -0.9398 |    -2.400 |
-#> |.....................|    -4.100 |  -0.01100 |    0.7316 |   0.06722 |
-#> |.....................|    0.6751 |     1.587 |     1.269 |     1.154 |
-#> |.....................|     1.482 |     1.153 |...........|...........|
-#> |    X|     495.95762 |     101.5 |   0.01659 |    0.2809 |   0.09072 |
-#> |.....................|   0.01658 |    0.4973 |    0.7316 |   0.06722 |
-#> |.....................|    0.6751 |     1.587 |     1.269 |     1.154 |
-#> |.....................|     1.482 |     1.153 |...........|...........|
-#> |    F| Forward Diff. |     41.81 |    -3.013 |  -0.08916 |   -0.3303 |
-#> |.....................|    -1.914 |  0.005472 |    -23.39 |    -29.38 |
-#> |.....................|     3.465 |    -17.07 |    -12.49 |    -12.74 |
-#> |.....................|    -15.23 |    -9.735 |...........|...........|
-#> |    5|     495.32815 |     1.003 |   -0.9984 |   -0.9391 |   -0.9673 |
-#> |.....................|   -0.9991 |   -0.9214 |   -0.8962 |   -0.9051 |
-#> |.....................|   -0.9099 |   -0.8826 |   -0.8908 |   -0.8930 |
-#> |.....................|   -0.8855 |   -0.8944 |...........|...........|
-#> |    U|     495.32815 |     100.3 |    -4.098 |   -0.9398 |    -2.400 |
-#> |.....................|    -4.099 |  -0.01100 |    0.7340 |   0.06750 |
-#> |.....................|    0.6745 |     1.594 |     1.273 |     1.158 |
-#> |.....................|     1.488 |     1.156 |...........|...........|
-#> |    X|     495.32815 |     100.3 |   0.01660 |    0.2809 |   0.09073 |
-#> |.....................|   0.01659 |    0.4973 |    0.7340 |   0.06750 |
-#> |.....................|    0.6745 |     1.594 |     1.273 |     1.158 |
-#> |.....................|     1.488 |     1.156 |...........|...........|
-#> |    F| Forward Diff. |    -47.70 |    -3.739 |   -0.6694 |  -0.04580 |
-#> |.....................|    -1.870 |  0.006670 |    -22.76 |    -30.26 |
-#> |.....................|     3.613 |    -16.75 |    -12.29 |    -12.38 |
-#> |.....................|    -15.09 |    -9.486 |...........|...........|
-#> |    6|     494.72051 |     1.016 |   -0.9974 |   -0.9389 |   -0.9672 |
-#> |.....................|   -0.9986 |   -0.9214 |   -0.8902 |   -0.8971 |
-#> |.....................|   -0.9109 |   -0.8782 |   -0.8876 |   -0.8897 |
-#> |.....................|   -0.8816 |   -0.8919 |...........|...........|
-#> |    U|     494.72051 |     101.6 |    -4.097 |   -0.9397 |    -2.400 |
-#> |.....................|    -4.099 |  -0.01100 |    0.7362 |   0.06777 |
-#> |.....................|    0.6738 |     1.601 |     1.277 |     1.162 |
-#> |.....................|     1.494 |     1.159 |...........|...........|
-#> |    X|     494.72051 |     101.6 |   0.01662 |    0.2810 |   0.09073 |
-#> |.....................|   0.01660 |    0.4973 |    0.7362 |   0.06777 |
-#> |.....................|    0.6738 |     1.601 |     1.277 |     1.162 |
-#> |.....................|     1.494 |     1.159 |...........|...........|
-#> |    F| Forward Diff. |     48.34 |    -2.939 |  -0.03847 |   -0.3608 |
-#> |.....................|    -1.945 |  0.005434 |    -20.90 |    -26.17 |
-#> |.....................|     3.821 |    -17.00 |    -12.53 |    -12.70 |
-#> |.....................|    -15.56 |    -9.587 |...........|...........|
-#> |    7|     494.15722 |     1.003 |   -0.9966 |   -0.9389 |   -0.9671 |
-#> |.....................|   -0.9981 |   -0.9214 |   -0.8845 |   -0.8900 |
-#> |.....................|   -0.9119 |   -0.8736 |   -0.8842 |   -0.8863 |
-#> |.....................|   -0.8773 |   -0.8893 |...........|...........|
-#> |    U|     494.15722 |     100.3 |    -4.097 |   -0.9396 |    -2.400 |
-#> |.....................|    -4.098 |  -0.01100 |    0.7383 |   0.06800 |
-#> |.....................|    0.6731 |     1.608 |     1.282 |     1.166 |
-#> |.....................|     1.500 |     1.162 |...........|...........|
-#> |    X|     494.15722 |     100.3 |   0.01663 |    0.2810 |   0.09074 |
-#> |.....................|   0.01660 |    0.4973 |    0.7383 |   0.06800 |
-#> |.....................|    0.6731 |     1.608 |     1.282 |     1.166 |
-#> |.....................|     1.500 |     1.162 |...........|...........|
-#> |    F| Forward Diff. |    -50.36 |    -3.770 |   -0.7003 |  -0.03307 |
-#> |.....................|    -1.882 |  0.006830 |    -20.02 |    -28.64 |
-#> |.....................|     3.020 |    -16.49 |    -12.31 |    -12.33 |
-#> |.....................|    -14.87 |    -9.319 |...........|...........|
-#> |    8|     493.49185 |     1.015 |   -0.9955 |   -0.9387 |   -0.9671 |
-#> |.....................|   -0.9975 |   -0.9214 |   -0.8787 |   -0.8818 |
-#> |.....................|   -0.9128 |   -0.8688 |   -0.8806 |   -0.8827 |
-#> |.....................|   -0.8730 |   -0.8866 |...........|...........|
-#> |    U|     493.49185 |     101.5 |    -4.096 |   -0.9395 |    -2.400 |
-#> |.....................|    -4.098 |  -0.01100 |    0.7404 |   0.06828 |
-#> |.....................|    0.6725 |     1.616 |     1.286 |     1.170 |
-#> |.....................|     1.507 |     1.165 |...........|...........|
-#> |    X|     493.49185 |     101.5 |   0.01665 |    0.2810 |   0.09074 |
-#> |.....................|   0.01661 |    0.4973 |    0.7404 |   0.06828 |
-#> |.....................|    0.6725 |     1.616 |     1.286 |     1.170 |
-#> |.....................|     1.507 |     1.165 |...........|...........|
-#> |    F| Forward Diff. |     41.03 |    -2.976 |  -0.07989 |   -0.3421 |
-#> |.....................|    -1.950 |  0.005619 |    -20.95 |    -25.58 |
-#> |.....................|     3.377 |    -16.59 |    -11.95 |    -12.23 |
-#> |.....................|    -14.73 |    -9.398 |...........|...........|
-#> |    9|     492.95463 |     1.003 |   -0.9946 |   -0.9387 |   -0.9670 |
-#> |.....................|   -0.9969 |   -0.9215 |   -0.8725 |   -0.8742 |
-#> |.....................|   -0.9138 |   -0.8639 |   -0.8771 |   -0.8790 |
-#> |.....................|   -0.8686 |   -0.8839 |...........|...........|
-#> |    U|     492.95463 |     100.3 |    -4.095 |   -0.9394 |    -2.400 |
-#> |.....................|    -4.097 |  -0.01100 |    0.7427 |   0.06853 |
-#> |.....................|    0.6718 |     1.624 |     1.291 |     1.174 |
-#> |.....................|     1.513 |     1.168 |...........|...........|
-#> |    X|     492.95463 |     100.3 |   0.01666 |    0.2810 |   0.09075 |
-#> |.....................|   0.01662 |    0.4973 |    0.7427 |   0.06853 |
-#> |.....................|    0.6718 |     1.624 |     1.291 |     1.174 |
-#> |.....................|     1.513 |     1.168 |...........|...........|
-#> |    F| Forward Diff. |    -49.97 |    -3.772 |   -0.7121 |  -0.02926 |
-#> |.....................|    -1.890 |  0.006985 |    -18.86 |    -26.85 |
-#> |.....................|     2.866 |    -16.28 |    -11.70 |    -11.82 |
-#> |.....................|    -14.59 |    -9.132 |...........|...........|
-#> |   10|     492.31444 |     1.015 |   -0.9935 |   -0.9385 |   -0.9670 |
-#> |.....................|   -0.9964 |   -0.9215 |   -0.8668 |   -0.8662 |
-#> |.....................|   -0.9147 |   -0.8589 |   -0.8735 |   -0.8755 |
-#> |.....................|   -0.8642 |   -0.8811 |...........|...........|
-#> |    U|     492.31444 |     101.5 |    -4.094 |   -0.9393 |    -2.400 |
-#> |.....................|    -4.096 |  -0.01100 |    0.7448 |   0.06880 |
-#> |.....................|    0.6712 |     1.632 |     1.295 |     1.178 |
-#> |.....................|     1.520 |     1.172 |...........|...........|
-#> |    X|     492.31444 |     101.5 |   0.01668 |    0.2810 |   0.09075 |
-#> |.....................|   0.01663 |    0.4972 |    0.7448 |   0.06880 |
-#> |.....................|    0.6712 |     1.632 |     1.295 |     1.178 |
-#> |.....................|     1.520 |     1.172 |...........|...........|
-#> |    F| Forward Diff. |     40.47 |    -2.944 |  -0.07505 |   -0.3464 |
-#> |.....................|    -1.962 |  0.005707 |    -18.58 |    -22.75 |
-#> |.....................|     3.454 |    -16.50 |    -11.93 |    -12.14 |
-#> |.....................|    -15.04 |    -9.193 |...........|...........|
-#> |   11|     491.79472 |     1.003 |   -0.9926 |   -0.9385 |   -0.9669 |
-#> |.....................|   -0.9957 |   -0.9215 |   -0.8609 |   -0.8590 |
-#> |.....................|   -0.9158 |   -0.8537 |   -0.8697 |   -0.8716 |
-#> |.....................|   -0.8594 |   -0.8781 |...........|...........|
-#> |    U|     491.79472 |     100.3 |    -4.093 |   -0.9392 |    -2.400 |
-#> |.....................|    -4.096 |  -0.01100 |    0.7469 |   0.06904 |
-#> |.....................|    0.6705 |     1.640 |     1.300 |     1.183 |
-#> |.....................|     1.527 |     1.175 |...........|...........|
-#> |    X|     491.79472 |     100.3 |   0.01670 |    0.2811 |   0.09076 |
-#> |.....................|   0.01664 |    0.4972 |    0.7469 |   0.06904 |
-#> |.....................|    0.6705 |     1.640 |     1.300 |     1.183 |
-#> |.....................|     1.527 |     1.175 |...........|...........|
-#> |    F| Forward Diff. |    -48.84 |    -3.756 |   -0.7183 |  -0.02810 |
-#> |.....................|    -1.902 |  0.007122 |    -19.51 |    -25.13 |
-#> |.....................|     2.711 |    -16.03 |    -11.73 |    -11.80 |
-#> |.....................|    -14.28 |    -8.965 |...........|...........|
-#> |   12|     491.12641 |     1.014 |   -0.9913 |   -0.9383 |   -0.9669 |
-#> |.....................|   -0.9951 |   -0.9215 |   -0.8546 |   -0.8511 |
-#> |.....................|   -0.9167 |   -0.8483 |   -0.8658 |   -0.8677 |
-#> |.....................|   -0.8546 |   -0.8752 |...........|...........|
-#> |    U|     491.12641 |     101.4 |    -4.091 |   -0.9390 |    -2.400 |
-#> |.....................|    -4.095 |  -0.01100 |    0.7492 |   0.06931 |
-#> |.....................|    0.6699 |     1.648 |     1.305 |     1.187 |
-#> |.....................|     1.534 |     1.178 |...........|...........|
-#> |    X|     491.12641 |     101.4 |   0.01672 |    0.2811 |   0.09076 |
-#> |.....................|   0.01665 |    0.4972 |    0.7492 |   0.06931 |
-#> |.....................|    0.6699 |     1.648 |     1.305 |     1.187 |
-#> |.....................|     1.534 |     1.178 |...........|...........|
-#> |    F| Forward Diff. |     34.57 |    -2.950 |   -0.1076 |   -0.3310 |
-#> |.....................|    -1.967 |  0.005897 |    -18.06 |    -21.71 |
-#> |.....................|     3.154 |    -16.24 |    -11.62 |    -11.87 |
-#> |.....................|    -14.73 |    -8.995 |...........|...........|
-#> |   13|     490.65951 |     1.002 |   -0.9903 |   -0.9382 |   -0.9668 |
-#> |.....................|   -0.9944 |   -0.9215 |   -0.8485 |   -0.8438 |
-#> |.....................|   -0.9178 |   -0.8429 |   -0.8619 |   -0.8637 |
-#> |.....................|   -0.8496 |   -0.8721 |...........|...........|
-#> |    U|     490.65951 |     100.2 |    -4.090 |   -0.9390 |    -2.399 |
-#> |.....................|    -4.094 |  -0.01100 |    0.7514 |   0.06955 |
-#> |.....................|    0.6692 |     1.657 |     1.310 |     1.192 |
-#> |.....................|     1.541 |     1.182 |...........|...........|
-#> |    X|     490.65951 |     100.2 |   0.01673 |    0.2811 |   0.09077 |
-#> |.....................|   0.01667 |    0.4972 |    0.7514 |   0.06955 |
-#> |.....................|    0.6692 |     1.657 |     1.310 |     1.192 |
-#> |.....................|     1.541 |     1.182 |...........|...........|
-#> |    F| Forward Diff. |    -50.76 |    -3.759 |   -0.7472 |  -0.01668 |
-#> |.....................|    -1.908 |  0.007323 |    -16.70 |    -21.90 |
-#> |.....................|     3.094 |    -15.72 |    -11.38 |    -11.47 |
-#> |.....................|    -14.04 |    -8.745 |...........|...........|
-#> |   14|     490.01300 |     1.014 |   -0.9891 |   -0.9380 |   -0.9667 |
-#> |.....................|   -0.9937 |   -0.9215 |   -0.8428 |   -0.8366 |
-#> |.....................|   -0.9189 |   -0.8372 |   -0.8579 |   -0.8596 |
-#> |.....................|   -0.8446 |   -0.8690 |...........|...........|
-#> |    U|       490.013 |     101.4 |    -4.089 |   -0.9388 |    -2.399 |
-#> |.....................|    -4.094 |  -0.01100 |    0.7535 |   0.06979 |
-#> |.....................|    0.6684 |     1.666 |     1.315 |     1.196 |
-#> |.....................|     1.549 |     1.186 |...........|...........|
-#> |    X|       490.013 |     101.4 |   0.01676 |    0.2811 |   0.09077 |
-#> |.....................|   0.01668 |    0.4972 |    0.7535 |   0.06979 |
-#> |.....................|    0.6684 |     1.666 |     1.315 |     1.196 |
-#> |.....................|     1.549 |     1.186 |...........|...........|
-#> |    F| Forward Diff. |     34.25 |    -2.890 |  -0.09666 |   -0.3362 |
-#> |.....................|    -1.973 |  0.006003 |    -17.09 |    -20.19 |
-#> |.....................|     3.007 |    -15.95 |    -11.25 |    -11.56 |
-#> |.....................|    -14.42 |    -8.788 |...........|...........|
-#> |   15|     489.51603 |     1.003 |   -0.9880 |   -0.9380 |   -0.9666 |
-#> |.....................|   -0.9930 |   -0.9215 |   -0.8366 |   -0.8294 |
-#> |.....................|   -0.9200 |   -0.8313 |   -0.8537 |   -0.8553 |
-#> |.....................|   -0.8392 |   -0.8658 |...........|...........|
-#> |    U|     489.51603 |     100.3 |    -4.088 |   -0.9388 |    -2.399 |
-#> |.....................|    -4.093 |  -0.01100 |    0.7558 |   0.07003 |
-#> |.....................|    0.6677 |     1.675 |     1.320 |     1.201 |
-#> |.....................|     1.556 |     1.189 |...........|...........|
-#> |    X|     489.51603 |     100.3 |   0.01677 |    0.2812 |   0.09078 |
-#> |.....................|   0.01669 |    0.4972 |    0.7558 |   0.07003 |
-#> |.....................|    0.6677 |     1.675 |     1.320 |     1.201 |
-#> |.....................|     1.556 |     1.189 |...........|...........|
-#> |    F| Forward Diff. |    -45.29 |    -3.673 |   -0.7179 |  -0.03084 |
-#> |.....................|    -1.907 |  0.007423 |    -17.34 |    -21.86 |
-#> |.....................|     2.565 |    -15.52 |    -11.05 |    -11.19 |
-#> |.....................|    -14.28 |    -8.545 |...........|...........|
-#> |   16|     488.89410 |     1.014 |   -0.9866 |   -0.9377 |   -0.9666 |
-#> |.....................|   -0.9922 |   -0.9215 |   -0.8304 |   -0.8220 |
-#> |.....................|   -0.9210 |   -0.8254 |   -0.8495 |   -0.8510 |
-#> |.....................|   -0.8337 |   -0.8625 |...........|...........|
-#> |    U|      488.8941 |     101.4 |    -4.087 |   -0.9385 |    -2.399 |
-#> |.....................|    -4.092 |  -0.01100 |    0.7580 |   0.07028 |
-#> |.....................|    0.6670 |     1.685 |     1.325 |     1.206 |
-#> |.....................|     1.565 |     1.193 |...........|...........|
-#> |    X|      488.8941 |     101.4 |   0.01680 |    0.2812 |   0.09079 |
-#> |.....................|   0.01670 |    0.4972 |    0.7580 |   0.07028 |
-#> |.....................|    0.6670 |     1.685 |     1.325 |     1.206 |
-#> |.....................|     1.565 |     1.193 |...........|...........|
-#> |    F| Forward Diff. |     32.56 |    -2.827 |  -0.09853 |   -0.3366 |
-#> |.....................|    -1.968 |  0.006143 |    -15.42 |    -18.16 |
-#> |.....................|     2.733 |    -15.52 |    -10.94 |    -11.25 |
-#> |.....................|    -14.13 |    -8.583 |...........|...........|
-#> |   17|     488.48678 |     1.002 |   -0.9855 |   -0.9377 |   -0.9664 |
-#> |.....................|   -0.9915 |   -0.9215 |   -0.8246 |   -0.8152 |
-#> |.....................|   -0.9220 |   -0.8195 |   -0.8454 |   -0.8468 |
-#> |.....................|   -0.8284 |   -0.8593 |...........|...........|
-#> |    U|     488.48678 |     100.2 |    -4.086 |   -0.9385 |    -2.399 |
-#> |.....................|    -4.091 |  -0.01100 |    0.7601 |   0.07051 |
-#> |.....................|    0.6663 |     1.694 |     1.331 |     1.211 |
-#> |.....................|     1.572 |     1.197 |...........|...........|
-#> |    X|     488.48678 |     100.2 |   0.01681 |    0.2812 |   0.09080 |
-#> |.....................|   0.01671 |    0.4972 |    0.7601 |   0.07051 |
-#> |.....................|    0.6663 |     1.694 |     1.331 |     1.211 |
-#> |.....................|     1.572 |     1.197 |...........|...........|
-#> |    F| Forward Diff. |    -50.86 |    -3.681 |   -0.7723 |-0.0007467 |
-#> |.....................|    -1.892 |  0.007742 |    -16.40 |    -20.55 |
-#> |.....................|     2.306 |    -15.16 |    -10.65 |    -10.82 |
-#> |.....................|    -14.00 |    -8.331 |...........|...........|
-#> |   18|     487.81394 |     1.012 |   -0.9841 |   -0.9374 |   -0.9664 |
-#> |.....................|   -0.9907 |   -0.9215 |   -0.8186 |   -0.8083 |
-#> |.....................|   -0.9229 |   -0.8132 |   -0.8411 |   -0.8424 |
-#> |.....................|   -0.8225 |   -0.8558 |...........|...........|
-#> |    U|     487.81394 |     101.2 |    -4.084 |   -0.9383 |    -2.399 |
-#> |.....................|    -4.091 |  -0.01100 |    0.7623 |   0.07074 |
-#> |.....................|    0.6657 |     1.704 |     1.336 |     1.216 |
-#> |.....................|     1.581 |     1.201 |...........|...........|
-#> |    X|     487.81394 |     101.2 |   0.01684 |    0.2812 |   0.09080 |
-#> |.....................|   0.01673 |    0.4972 |    0.7623 |   0.07074 |
-#> |.....................|    0.6657 |     1.704 |     1.336 |     1.216 |
-#> |.....................|     1.581 |     1.201 |...........|...........|
-#> |    F| Forward Diff. |     24.73 |    -2.818 |   -0.1513 |   -0.3103 |
-#> |.....................|    -1.952 |  0.006413 |    -14.43 |    -16.89 |
-#> |.....................|     2.774 |    -15.21 |    -10.56 |    -10.91 |
-#> |.....................|    -13.80 |    -8.354 |...........|...........|
-#> |   19|     487.41354 |     1.002 |   -0.9829 |   -0.9374 |   -0.9663 |
-#> |.....................|   -0.9898 |   -0.9215 |   -0.8126 |   -0.8013 |
-#> |.....................|   -0.9240 |   -0.8068 |   -0.8367 |   -0.8378 |
-#> |.....................|   -0.8167 |   -0.8523 |...........|...........|
-#> |    U|     487.41354 |     100.2 |    -4.083 |   -0.9382 |    -2.399 |
-#> |.....................|    -4.090 |  -0.01100 |    0.7645 |   0.07098 |
-#> |.....................|    0.6649 |     1.714 |     1.342 |     1.221 |
-#> |.....................|     1.590 |     1.205 |...........|...........|
-#> |    X|     487.41354 |     100.2 |   0.01686 |    0.2813 |   0.09082 |
-#> |.....................|   0.01674 |    0.4972 |    0.7645 |   0.07098 |
-#> |.....................|    0.6649 |     1.714 |     1.342 |     1.221 |
-#> |.....................|     1.590 |     1.205 |...........|...........|
-#> |    F| Forward Diff. |    -49.04 |    -3.605 |   -0.7738 | -0.005231 |
-#> |.....................|    -1.885 |  0.007887 |    -13.75 |    -19.14 |
-#> |.....................|     2.153 |    -14.90 |    -10.33 |    -10.54 |
-#> |.....................|    -13.68 |    -8.125 |...........|...........|
-#> |   20|     486.77105 |     1.012 |   -0.9814 |   -0.9371 |   -0.9662 |
-#> |.....................|   -0.9889 |   -0.9215 |   -0.8076 |   -0.7947 |
-#> |.....................|   -0.9250 |   -0.7999 |   -0.8321 |   -0.8330 |
-#> |.....................|   -0.8104 |   -0.8486 |...........|...........|
-#> |    U|     486.77105 |     101.2 |    -4.081 |   -0.9380 |    -2.399 |
-#> |.....................|    -4.089 |  -0.01100 |    0.7664 |   0.07119 |
-#> |.....................|    0.6643 |     1.725 |     1.347 |     1.227 |
-#> |.....................|     1.599 |     1.209 |...........|...........|
-#> |    X|     486.77105 |     101.2 |   0.01688 |    0.2813 |   0.09082 |
-#> |.....................|   0.01676 |    0.4972 |    0.7664 |   0.07119 |
-#> |.....................|    0.6643 |     1.725 |     1.347 |     1.227 |
-#> |.....................|     1.599 |     1.209 |...........|...........|
-#> |    F| Forward Diff. |     24.27 |    -2.713 |   -0.1438 |   -0.3142 |
-#> |.....................|    -1.939 |  0.006562 |    -14.18 |    -16.12 |
-#> |.....................|     2.525 |    -14.86 |    -10.17 |    -10.57 |
-#> |.....................|    -13.46 |    -8.131 |...........|...........|
-#> |   21|     486.40106 |     1.002 |   -0.9802 |   -0.9371 |   -0.9661 |
-#> |.....................|   -0.9881 |   -0.9215 |   -0.8015 |   -0.7878 |
-#> |.....................|   -0.9261 |   -0.7935 |   -0.8277 |   -0.8285 |
-#> |.....................|   -0.8046 |   -0.8452 |...........|...........|
-#> |    U|     486.40106 |     100.2 |    -4.080 |   -0.9379 |    -2.399 |
-#> |.....................|    -4.088 |  -0.01100 |    0.7686 |   0.07143 |
-#> |.....................|    0.6635 |     1.735 |     1.353 |     1.232 |
-#> |.....................|     1.608 |     1.213 |...........|...........|
-#> |    X|     486.40106 |     100.2 |   0.01690 |    0.2813 |   0.09083 |
-#> |.....................|   0.01677 |    0.4972 |    0.7686 |   0.07143 |
-#> |.....................|    0.6635 |     1.735 |     1.353 |     1.232 |
-#> |.....................|     1.608 |     1.213 |...........|...........|
-#> |    F| Forward Diff. |    -49.43 |    -3.533 |   -0.7907 |  0.002583 |
-#> |.....................|    -1.861 |  0.008122 |    -12.85 |    -17.77 |
-#> |.....................|     2.313 |    -14.52 |    -9.868 |    -10.18 |
-#> |.....................|    -13.34 |    -7.899 |...........|...........|
-#> |   22|     485.77865 |     1.012 |   -0.9786 |   -0.9368 |   -0.9660 |
-#> |.....................|   -0.9871 |   -0.9215 |   -0.7966 |   -0.7818 |
-#> |.....................|   -0.9271 |   -0.7864 |   -0.8231 |   -0.8237 |
-#> |.....................|   -0.7980 |   -0.8414 |...........|...........|
-#> |    U|     485.77865 |     101.2 |    -4.079 |   -0.9376 |    -2.399 |
-#> |.....................|    -4.087 |  -0.01100 |    0.7704 |   0.07163 |
-#> |.....................|    0.6629 |     1.746 |     1.359 |     1.238 |
-#> |.....................|     1.617 |     1.217 |...........|...........|
-#> |    X|     485.77865 |     101.2 |   0.01693 |    0.2814 |   0.09084 |
-#> |.....................|   0.01679 |    0.4972 |    0.7704 |   0.07163 |
-#> |.....................|    0.6629 |     1.746 |     1.359 |     1.238 |
-#> |.....................|     1.617 |     1.217 |...........|...........|
-#> |    F| Forward Diff. |     23.77 |    -2.587 |   -0.1355 |   -0.3176 |
-#> |.....................|    -1.913 |  0.006717 |    -13.39 |    -15.00 |
-#> |.....................|     2.211 |    -14.53 |    -9.747 |    -10.22 |
-#> |.....................|    -13.16 |    -7.915 |...........|...........|
-#> |   23|     485.42886 |     1.002 |   -0.9775 |   -0.9367 |   -0.9659 |
-#> |.....................|   -0.9862 |   -0.9215 |   -0.7907 |   -0.7751 |
-#> |.....................|   -0.9281 |   -0.7799 |   -0.8187 |   -0.8190 |
-#> |.....................|   -0.7921 |   -0.8378 |...........|...........|
-#> |    U|     485.42886 |     100.2 |    -4.077 |   -0.9376 |    -2.399 |
-#> |.....................|    -4.086 |  -0.01100 |    0.7725 |   0.07185 |
-#> |.....................|    0.6622 |     1.757 |     1.364 |     1.243 |
-#> |.....................|     1.626 |     1.221 |...........|...........|
-#> |    X|     485.42886 |     100.2 |   0.01695 |    0.2814 |   0.09085 |
-#> |.....................|   0.01680 |    0.4972 |    0.7725 |   0.07185 |
-#> |.....................|    0.6622 |     1.757 |     1.364 |     1.243 |
-#> |.....................|     1.626 |     1.221 |...........|...........|
-#> |    F| Forward Diff. |    -48.95 |    -3.431 |   -0.7980 |  0.007511 |
-#> |.....................|    -1.828 |  0.008340 |    -12.05 |    -16.59 |
-#> |.....................|     2.177 |    -14.27 |    -9.567 |    -9.843 |
-#> |.....................|    -12.98 |    -7.655 |...........|...........|
-#> |   24|     484.82183 |     1.012 |   -0.9759 |   -0.9364 |   -0.9658 |
-#> |.....................|   -0.9852 |   -0.9215 |   -0.7861 |   -0.7697 |
-#> |.....................|   -0.9290 |   -0.7723 |   -0.8141 |   -0.8141 |
-#> |.....................|   -0.7852 |   -0.8339 |...........|...........|
-#> |    U|     484.82183 |     101.2 |    -4.076 |   -0.9373 |    -2.398 |
-#> |.....................|    -4.085 |  -0.01100 |    0.7742 |   0.07203 |
-#> |.....................|    0.6616 |     1.769 |     1.370 |     1.249 |
-#> |.....................|     1.636 |     1.226 |...........|...........|
-#> |    X|     484.82183 |     101.2 |   0.01698 |    0.2814 |   0.09086 |
-#> |.....................|   0.01682 |    0.4972 |    0.7742 |   0.07203 |
-#> |.....................|    0.6616 |     1.769 |     1.370 |     1.249 |
-#> |.....................|     1.636 |     1.226 |...........|...........|
-#> |    F| Forward Diff. |     22.05 |    -2.460 |   -0.1372 |   -0.3150 |
-#> |.....................|    -1.875 |  0.006918 |    -12.51 |    -13.87 |
-#> |.....................|     2.059 |    -14.26 |    -9.441 |    -9.910 |
-#> |.....................|    -12.81 |    -7.688 |...........|...........|
-#> |   25|     484.49026 |     1.002 |   -0.9747 |   -0.9363 |   -0.9656 |
-#> |.....................|   -0.9843 |   -0.9215 |   -0.7802 |   -0.7632 |
-#> |.....................|   -0.9300 |   -0.7655 |   -0.8095 |   -0.8093 |
-#> |.....................|   -0.7791 |   -0.8302 |...........|...........|
-#> |    U|     484.49026 |     100.2 |    -4.075 |   -0.9372 |    -2.398 |
-#> |.....................|    -4.084 |  -0.01100 |    0.7764 |   0.07225 |
-#> |.....................|    0.6609 |     1.779 |     1.376 |     1.254 |
-#> |.....................|     1.645 |     1.230 |...........|...........|
-#> |    X|     484.49026 |     100.2 |   0.01700 |    0.2815 |   0.09087 |
-#> |.....................|   0.01684 |    0.4972 |    0.7764 |   0.07225 |
-#> |.....................|    0.6609 |     1.779 |     1.376 |     1.254 |
-#> |.....................|     1.645 |     1.230 |...........|...........|
-#> |    F| Forward Diff. |    -48.40 |    -3.314 |   -0.8046 |   0.01082 |
-#> |.....................|    -1.785 |  0.008564 |    -11.34 |    -13.90 |
-#> |.....................|     2.095 |    -13.95 |    -9.157 |    -9.483 |
-#> |.....................|    -12.66 |    -7.448 |...........|...........|
-#> |   26|     483.91316 |     1.012 |   -0.9731 |   -0.9360 |   -0.9656 |
-#> |.....................|   -0.9832 |   -0.9215 |   -0.7758 |   -0.7593 |
-#> |.....................|   -0.9309 |   -0.7575 |   -0.8048 |   -0.8042 |
-#> |.....................|   -0.7719 |   -0.8261 |...........|...........|
-#> |    U|     483.91316 |     101.2 |    -4.073 |   -0.9369 |    -2.398 |
-#> |.....................|    -4.083 |  -0.01100 |    0.7780 |   0.07238 |
-#> |.....................|    0.6603 |     1.792 |     1.382 |     1.260 |
-#> |.....................|     1.656 |     1.235 |...........|...........|
-#> |    X|     483.91316 |     101.2 |   0.01702 |    0.2815 |   0.09088 |
-#> |.....................|   0.01685 |    0.4972 |    0.7780 |   0.07238 |
-#> |.....................|    0.6603 |     1.792 |     1.382 |     1.260 |
-#> |.....................|     1.656 |     1.235 |...........|...........|
-#> |    F| Forward Diff. |     21.71 |    -2.295 |   -0.1241 |   -0.3190 |
-#> |.....................|    -1.824 |  0.007081 |    -13.14 |    -14.20 |
-#> |.....................|     1.713 |    -13.92 |    -9.049 |    -9.560 |
-#> |.....................|    -12.44 |    -7.439 |...........|...........|
-#> |   27|     483.53972 |     1.003 |   -0.9719 |   -0.9359 |   -0.9654 |
-#> |.....................|   -0.9822 |   -0.9215 |   -0.7695 |   -0.7529 |
-#> |.....................|   -0.9317 |   -0.7501 |   -0.8002 |   -0.7993 |
-#> |.....................|   -0.7653 |   -0.8222 |...........|...........|
-#> |    U|     483.53972 |     100.3 |    -4.072 |   -0.9368 |    -2.398 |
-#> |.....................|    -4.082 |  -0.01100 |    0.7803 |   0.07259 |
-#> |.....................|    0.6598 |     1.804 |     1.388 |     1.266 |
-#> |.....................|     1.666 |     1.239 |...........|...........|
-#> |    X|     483.53972 |     100.3 |   0.01705 |    0.2815 |   0.09089 |
-#> |.....................|   0.01687 |    0.4972 |    0.7803 |   0.07259 |
-#> |.....................|    0.6598 |     1.804 |     1.388 |     1.266 |
-#> |.....................|     1.666 |     1.239 |...........|...........|
-#> |    F| Forward Diff. |    -41.33 |    -3.086 |   -0.7421 |  -0.01550 |
-#> |.....................|    -1.732 |  0.008667 |    -12.24 |    -14.31 |
-#> |.....................|     1.879 |    -13.57 |    -8.704 |    -9.151 |
-#> |.....................|    -12.31 |    -7.231 |...........|...........|
-#> |   28|     483.02129 |     1.012 |   -0.9704 |   -0.9356 |   -0.9653 |
-#> |.....................|   -0.9811 |   -0.9215 |   -0.7639 |   -0.7482 |
-#> |.....................|   -0.9323 |   -0.7422 |   -0.7957 |   -0.7943 |
-#> |.....................|   -0.7582 |   -0.8182 |...........|...........|
-#> |    U|     483.02129 |     101.2 |    -4.070 |   -0.9365 |    -2.398 |
-#> |.....................|    -4.081 |  -0.01100 |    0.7823 |   0.07275 |
-#> |.....................|    0.6594 |     1.816 |     1.393 |     1.271 |
-#> |.....................|     1.676 |     1.244 |...........|...........|
-#> |    X|     483.02129 |     101.2 |   0.01707 |    0.2816 |   0.09090 |
-#> |.....................|   0.01689 |    0.4972 |    0.7823 |   0.07275 |
-#> |.....................|    0.6594 |     1.816 |     1.393 |     1.271 |
-#> |.....................|     1.676 |     1.244 |...........|...........|
-#> |    F| Forward Diff. |     24.99 |    -2.064 |  -0.07177 |   -0.3414 |
-#> |.....................|    -1.768 |  0.007186 |    -12.35 |    -13.09 |
-#> |.....................|     1.619 |    -13.63 |    -8.749 |    -9.199 |
-#> |.....................|    -12.40 |    -7.209 |...........|...........|
-#> |   29|     482.63111 |     1.003 |   -0.9692 |   -0.9355 |   -0.9651 |
-#> |.....................|   -0.9800 |   -0.9215 |   -0.7579 |   -0.7429 |
-#> |.....................|   -0.9329 |   -0.7344 |   -0.7911 |   -0.7893 |
-#> |.....................|   -0.7510 |   -0.8142 |...........|...........|
-#> |    U|     482.63111 |     100.3 |    -4.069 |   -0.9364 |    -2.398 |
-#> |.....................|    -4.080 |  -0.01100 |    0.7845 |   0.07293 |
-#> |.....................|    0.6589 |     1.829 |     1.399 |     1.277 |
-#> |.....................|     1.687 |     1.249 |...........|...........|
-#> |    X|     482.63111 |     100.3 |   0.01709 |    0.2816 |   0.09092 |
-#> |.....................|   0.01691 |    0.4972 |    0.7845 |   0.07293 |
-#> |.....................|    0.6589 |     1.829 |     1.399 |     1.277 |
-#> |.....................|     1.687 |     1.249 |...........|...........|
-#> |    F| Forward Diff. |    -36.55 |    -2.873 |   -0.6941 |  -0.03251 |
-#> |.....................|    -1.664 |  0.008820 |    -11.56 |    -13.31 |
-#> |.....................|     1.468 |    -13.22 |    -8.319 |    -8.815 |
-#> |.....................|    -11.93 |    -7.014 |...........|...........|
-#> |   30|     482.15860 |     1.013 |   -0.9679 |   -0.9352 |   -0.9650 |
-#> |.....................|   -0.9789 |   -0.9215 |   -0.7525 |   -0.7387 |
-#> |.....................|   -0.9332 |   -0.7261 |   -0.7866 |   -0.7843 |
-#> |.....................|   -0.7435 |   -0.8100 |...........|...........|
-#> |    U|      482.1586 |     101.3 |    -4.068 |   -0.9361 |    -2.398 |
-#> |.....................|    -4.079 |  -0.01100 |    0.7865 |   0.07307 |
-#> |.....................|    0.6587 |     1.842 |     1.405 |     1.283 |
-#> |.....................|     1.698 |     1.253 |...........|...........|
-#> |    X|      482.1586 |     101.3 |   0.01711 |    0.2817 |   0.09093 |
-#> |.....................|   0.01693 |    0.4972 |    0.7865 |   0.07307 |
-#> |.....................|    0.6587 |     1.842 |     1.405 |     1.283 |
-#> |.....................|     1.698 |     1.253 |...........|...........|
-#> |    F| Forward Diff. |     26.18 |    -1.853 |  -0.03641 |   -0.3540 |
-#> |.....................|    -1.697 |  0.007343 |    -10.35 |    -10.94 |
-#> |.....................|     1.762 |    -13.15 |    -8.194 |    -8.841 |
-#> |.....................|    -11.73 |    -7.013 |...........|...........|
-#> |   31|     481.77253 |     1.004 |   -0.9667 |   -0.9350 |   -0.9648 |
-#> |.....................|   -0.9778 |   -0.9215 |   -0.7477 |   -0.7350 |
-#> |.....................|   -0.9339 |   -0.7174 |   -0.7818 |   -0.7789 |
-#> |.....................|   -0.7358 |   -0.8055 |...........|...........|
-#> |    U|     481.77253 |     100.4 |    -4.067 |   -0.9360 |    -2.397 |
-#> |.....................|    -4.078 |  -0.01100 |    0.7882 |   0.07320 |
-#> |.....................|    0.6583 |     1.855 |     1.411 |     1.289 |
-#> |.....................|     1.709 |     1.259 |...........|...........|
-#> |    X|     481.77253 |     100.4 |   0.01713 |    0.2817 |   0.09095 |
-#> |.....................|   0.01695 |    0.4972 |    0.7882 |   0.07320 |
-#> |.....................|    0.6583 |     1.855 |     1.411 |     1.289 |
-#> |.....................|     1.709 |     1.259 |...........|...........|
-#> |    F| Forward Diff. |    -33.42 |    -2.468 |   -0.6588 |  -0.04495 |
-#> |.....................|    -1.582 |  0.009000 |    -9.278 |    -10.93 |
-#> |.....................|     2.073 |    -12.89 |    -7.995 |    -8.451 |
-#> |.....................|    -11.53 |    -6.784 |...........|...........|
-#> |   32|     481.33405 |     1.012 |   -0.9656 |   -0.9347 |   -0.9646 |
-#> |.....................|   -0.9766 |   -0.9215 |   -0.7446 |   -0.7329 |
-#> |.....................|   -0.9352 |   -0.7079 |   -0.7769 |   -0.7733 |
-#> |.....................|   -0.7275 |   -0.8008 |...........|...........|
-#> |    U|     481.33405 |     101.2 |    -4.066 |   -0.9357 |    -2.397 |
-#> |.....................|    -4.077 |  -0.01100 |    0.7894 |   0.07326 |
-#> |.....................|    0.6574 |     1.870 |     1.417 |     1.296 |
-#> |.....................|     1.721 |     1.264 |...........|...........|
-#> |    X|     481.33405 |     101.2 |   0.01715 |    0.2818 |   0.09096 |
-#> |.....................|   0.01697 |    0.4972 |    0.7894 |   0.07326 |
-#> |.....................|    0.6574 |     1.870 |     1.417 |     1.296 |
-#> |.....................|     1.721 |     1.264 |...........|...........|
-#> |    F| Forward Diff. |     23.32 |    -1.710 |  -0.03967 |   -0.3452 |
-#> |.....................|    -1.599 |  0.007614 |    -9.890 |    -10.44 |
-#> |.....................|     1.650 |    -12.78 |    -7.841 |    -8.441 |
-#> |.....................|    -11.31 |    -6.748 |...........|...........|
-#> |   33|     480.95912 |     1.004 |   -0.9646 |   -0.9346 |   -0.9644 |
-#> |.....................|   -0.9754 |   -0.9215 |   -0.7406 |   -0.7300 |
-#> |.....................|   -0.9364 |   -0.6985 |   -0.7720 |   -0.7677 |
-#> |.....................|   -0.7193 |   -0.7960 |...........|...........|
-#> |    U|     480.95912 |     100.4 |    -4.065 |   -0.9356 |    -2.397 |
-#> |.....................|    -4.075 |  -0.01100 |    0.7908 |   0.07336 |
-#> |.....................|    0.6566 |     1.885 |     1.424 |     1.302 |
-#> |.....................|     1.734 |     1.270 |...........|...........|
-#> |    X|     480.95912 |     100.4 |   0.01717 |    0.2818 |   0.09098 |
-#> |.....................|   0.01699 |    0.4972 |    0.7908 |   0.07336 |
-#> |.....................|    0.6566 |     1.885 |     1.424 |     1.302 |
-#> |.....................|     1.734 |     1.270 |...........|...........|
-#> |    F| Forward Diff. |    -30.38 |    -2.273 |   -0.6168 |  -0.05646 |
-#> |.....................|    -1.481 |  0.009185 |    -8.899 |    -11.86 |
-#> |.....................|     1.510 |    -12.49 |    -7.578 |    -8.069 |
-#> |.....................|    -11.13 |    -6.546 |...........|...........|
-#> |   34|     480.53887 |     1.012 |   -0.9637 |   -0.9342 |   -0.9642 |
-#> |.....................|   -0.9743 |   -0.9216 |   -0.7379 |   -0.7267 |
-#> |.....................|   -0.9369 |   -0.6888 |   -0.7673 |   -0.7623 |
-#> |.....................|   -0.7109 |   -0.7912 |...........|...........|
-#> |    U|     480.53887 |     101.2 |    -4.064 |   -0.9352 |    -2.397 |
-#> |.....................|    -4.074 |  -0.01100 |    0.7918 |   0.07347 |
-#> |.....................|    0.6562 |     1.901 |     1.429 |     1.308 |
-#> |.....................|     1.746 |     1.275 |...........|...........|
-#> |    X|     480.53887 |     101.2 |   0.01719 |    0.2819 |   0.09100 |
-#> |.....................|   0.01700 |    0.4972 |    0.7918 |   0.07347 |
-#> |.....................|    0.6562 |     1.901 |     1.429 |     1.308 |
-#> |.....................|     1.746 |     1.275 |...........|...........|
-#> |    F| Forward Diff. |     23.40 |    -1.545 | -0.009684 |   -0.3499 |
-#> |.....................|    -1.497 |  0.007817 |    -10.78 |    -11.16 |
-#> |.....................|     1.267 |    -12.36 |    -7.423 |    -8.042 |
-#> |.....................|    -10.90 |    -6.497 |...........|...........|
-#> |   35|     480.15983 |     1.005 |   -0.9631 |   -0.9341 |   -0.9640 |
-#> |.....................|   -0.9733 |   -0.9216 |   -0.7332 |   -0.7223 |
-#> |.....................|   -0.9371 |   -0.6793 |   -0.7629 |   -0.7571 |
-#> |.....................|   -0.7029 |   -0.7866 |...........|...........|
-#> |    U|     480.15983 |     100.5 |    -4.063 |   -0.9351 |    -2.397 |
-#> |.....................|    -4.073 |  -0.01100 |    0.7935 |   0.07362 |
-#> |.....................|    0.6561 |     1.916 |     1.435 |     1.314 |
-#> |.....................|     1.758 |     1.280 |...........|...........|
-#> |    X|     480.15983 |     100.5 |   0.01720 |    0.2819 |   0.09102 |
-#> |.....................|   0.01702 |    0.4972 |    0.7935 |   0.07362 |
-#> |.....................|    0.6561 |     1.916 |     1.435 |     1.314 |
-#> |.....................|     1.758 |     1.280 |...........|...........|
-#> |    F| Forward Diff. |    -28.57 |    -2.381 |   -0.5845 |  -0.05882 |
-#> |.....................|    -1.378 |  0.009420 |    -9.960 |    -11.12 |
-#> |.....................|     1.408 |    -12.08 |    -7.201 |    -7.708 |
-#> |.....................|    -10.66 |    -6.274 |...........|...........|
-#> |   36|     479.76525 |     1.013 |   -0.9621 |   -0.9338 |   -0.9638 |
-#> |.....................|   -0.9724 |   -0.9216 |   -0.7274 |   -0.7189 |
-#> |.....................|   -0.9370 |   -0.6698 |   -0.7590 |   -0.7523 |
-#> |.....................|   -0.6950 |   -0.7821 |...........|...........|
-#> |    U|     479.76525 |     101.3 |    -4.062 |   -0.9349 |    -2.396 |
-#> |.....................|    -4.072 |  -0.01100 |    0.7956 |   0.07373 |
-#> |.....................|    0.6562 |     1.931 |     1.440 |     1.320 |
-#> |.....................|     1.770 |     1.286 |...........|...........|
-#> |    X|     479.76525 |     101.3 |   0.01721 |    0.2819 |   0.09104 |
-#> |.....................|   0.01704 |    0.4972 |    0.7956 |   0.07373 |
-#> |.....................|    0.6562 |     1.931 |     1.440 |     1.320 |
-#> |.....................|     1.770 |     1.286 |...........|...........|
-#> |    F| Forward Diff. |     25.60 |    -1.145 |   0.04744 |   -0.3638 |
-#> |.....................|    -1.405 |  0.007969 |    -8.937 |    -9.159 |
-#> |.....................|     1.481 |    -11.97 |    -7.076 |    -7.721 |
-#> |.....................|    -10.46 |    -6.241 |...........|...........|
-#> |   37|     479.40619 |     1.005 |   -0.9617 |   -0.9337 |   -0.9635 |
-#> |.....................|   -0.9714 |   -0.9216 |   -0.7231 |   -0.7171 |
-#> |.....................|   -0.9376 |   -0.6597 |   -0.7546 |   -0.7470 |
-#> |.....................|   -0.6867 |   -0.7774 |...........|...........|
-#> |    U|     479.40619 |     100.5 |    -4.062 |   -0.9348 |    -2.396 |
-#> |.....................|    -4.071 |  -0.01100 |    0.7972 |   0.07380 |
-#> |.....................|    0.6558 |     1.947 |     1.445 |     1.326 |
-#> |.....................|     1.782 |     1.291 |...........|...........|
-#> |    X|     479.40619 |     100.5 |   0.01722 |    0.2820 |   0.09107 |
-#> |.....................|   0.01705 |    0.4972 |    0.7972 |   0.07380 |
-#> |.....................|    0.6558 |     1.947 |     1.445 |     1.326 |
-#> |.....................|     1.782 |     1.291 |...........|...........|
-#> |    F| Forward Diff. |    -26.68 |    -2.255 |   -0.5492 |  -0.06756 |
-#> |.....................|    -1.289 |  0.009576 |    -8.071 |    -10.65 |
-#> |.....................|     1.114 |    -11.68 |    -6.840 |    -7.373 |
-#> |.....................|    -10.30 |    -6.055 |...........|...........|
-#> |   38|     479.03445 |     1.012 |   -0.9610 |   -0.9335 |   -0.9633 |
-#> |.....................|   -0.9705 |   -0.9216 |   -0.7212 |   -0.7148 |
-#> |.....................|   -0.9376 |   -0.6492 |   -0.7503 |   -0.7416 |
-#> |.....................|   -0.6779 |   -0.7724 |...........|...........|
-#> |    U|     479.03445 |     101.2 |    -4.061 |   -0.9345 |    -2.396 |
-#> |.....................|    -4.071 |  -0.01100 |    0.7979 |   0.07387 |
-#> |.....................|    0.6558 |     1.963 |     1.451 |     1.332 |
-#> |.....................|     1.795 |     1.297 |...........|...........|
-#> |    X|     479.03445 |     101.2 |   0.01723 |    0.2820 |   0.09109 |
-#> |.....................|   0.01707 |    0.4972 |    0.7979 |   0.07387 |
-#> |.....................|    0.6558 |     1.963 |     1.451 |     1.332 |
-#> |.....................|     1.795 |     1.297 |...........|...........|
-#> |    F| Forward Diff. |     22.12 |    -1.081 |   0.03630 |   -0.3485 |
-#> |.....................|    -1.311 |  0.008233 |    -8.610 |    -8.856 |
-#> |.....................|     1.385 |    -11.53 |    -6.694 |    -7.351 |
-#> |.....................|    -10.05 |    -5.987 |...........|...........|
-#> |   39|     478.70046 |     1.005 |   -0.9607 |   -0.9334 |   -0.9629 |
-#> |.....................|   -0.9697 |   -0.9216 |   -0.7185 |   -0.7124 |
-#> |.....................|   -0.9378 |   -0.6386 |   -0.7461 |   -0.7363 |
-#> |.....................|   -0.6692 |   -0.7674 |...........|...........|
-#> |    U|     478.70046 |     100.5 |    -4.061 |   -0.9345 |    -2.396 |
-#> |.....................|    -4.070 |  -0.01100 |    0.7989 |   0.07395 |
-#> |.....................|    0.6557 |     1.980 |     1.456 |     1.338 |
-#> |.....................|     1.808 |     1.302 |...........|...........|
-#> |    X|     478.70046 |     100.5 |   0.01724 |    0.2820 |   0.09112 |
-#> |.....................|   0.01708 |    0.4972 |    0.7989 |   0.07395 |
-#> |.....................|    0.6557 |     1.980 |     1.456 |     1.338 |
-#> |.....................|     1.808 |     1.302 |...........|...........|
-#> |    F| Forward Diff. |    -26.51 |    -2.193 |   -0.5308 |  -0.05813 |
-#> |.....................|    -1.191 |  0.009843 |    -9.246 |    -10.25 |
-#> |.....................|     1.049 |    -11.25 |    -6.459 |    -7.012 |
-#> |.....................|    -9.842 |    -5.790 |...........|...........|
-#> |   40|     478.33460 |     1.012 |   -0.9602 |   -0.9332 |   -0.9627 |
-#> |.....................|   -0.9690 |   -0.9216 |   -0.7136 |   -0.7111 |
-#> |.....................|   -0.9376 |   -0.6278 |   -0.7425 |   -0.7314 |
-#> |.....................|   -0.6607 |   -0.7626 |...........|...........|
-#> |    U|      478.3346 |     101.2 |    -4.060 |   -0.9343 |    -2.395 |
-#> |.....................|    -4.069 |  -0.01100 |    0.8007 |   0.07400 |
-#> |.....................|    0.6558 |     1.997 |     1.461 |     1.344 |
-#> |.....................|     1.820 |     1.308 |...........|...........|
-#> |    X|      478.3346 |     101.2 |   0.01724 |    0.2821 |   0.09114 |
-#> |.....................|   0.01709 |    0.4972 |    0.8007 |   0.07400 |
-#> |.....................|    0.6558 |     1.997 |     1.461 |     1.344 |
-#> |.....................|     1.820 |     1.308 |...........|...........|
-#> |    F| Forward Diff. |     20.00 |    -1.246 |   0.04282 |   -0.3358 |
-#> |.....................|    -1.228 |  0.008460 |    -8.250 |    -8.533 |
-#> |.....................|     1.305 |    -11.09 |    -6.335 |    -6.999 |
-#> |.....................|    -9.637 |    -5.739 |...........|...........|
-#> |   41|     478.02904 |     1.005 |   -0.9595 |   -0.9333 |   -0.9623 |
-#> |.....................|   -0.9683 |   -0.9217 |   -0.7087 |   -0.7092 |
-#> |.....................|   -0.9377 |   -0.6173 |   -0.7388 |   -0.7264 |
-#> |.....................|   -0.6523 |   -0.7577 |...........|...........|
-#> |    U|     478.02904 |     100.5 |    -4.060 |   -0.9343 |    -2.395 |
-#> |.....................|    -4.068 |  -0.01100 |    0.8025 |   0.07406 |
-#> |.....................|    0.6557 |     2.014 |     1.466 |     1.350 |
-#> |.....................|     1.833 |     1.314 |...........|...........|
-#> |    X|     478.02904 |     100.5 |   0.01726 |    0.2820 |   0.09117 |
-#> |.....................|   0.01711 |    0.4972 |    0.8025 |   0.07406 |
-#> |.....................|    0.6557 |     2.014 |     1.466 |     1.350 |
-#> |.....................|     1.833 |     1.314 |...........|...........|
-#> |    F| Forward Diff. |    -28.91 |    -2.133 |   -0.5430 |  -0.03427 |
-#> |.....................|    -1.114 |   0.01012 |    -7.324 |    -9.914 |
-#> |.....................|    0.9278 |    -10.81 |    -6.119 |    -6.673 |
-#> |.....................|    -9.457 |    -5.557 |...........|...........|
-#> |   42|     477.67480 |     1.012 |   -0.9587 |   -0.9331 |   -0.9620 |
-#> |.....................|   -0.9677 |   -0.9217 |   -0.7077 |   -0.7075 |
-#> |.....................|   -0.9374 |   -0.6060 |   -0.7354 |   -0.7215 |
-#> |.....................|   -0.6433 |   -0.7527 |...........|...........|
-#> |    U|      477.6748 |     101.2 |    -4.059 |   -0.9342 |    -2.395 |
-#> |.....................|    -4.068 |  -0.01100 |    0.8028 |   0.07412 |
-#> |.....................|    0.6559 |     2.032 |     1.470 |     1.355 |
-#> |.....................|     1.846 |     1.319 |...........|...........|
-#> |    X|      477.6748 |     101.2 |   0.01727 |    0.2821 |   0.09120 |
-#> |.....................|   0.01712 |    0.4972 |    0.8028 |   0.07412 |
-#> |.....................|    0.6559 |     2.032 |     1.470 |     1.355 |
-#> |.....................|     1.846 |     1.319 |...........|...........|
-#> |    F| Forward Diff. |     17.58 |    -1.074 |   0.03251 |   -0.3151 |
-#> |.....................|    -1.162 |  0.008688 |    -9.226 |    -9.481 |
-#> |.....................|    0.9303 |    -10.65 |    -6.004 |    -6.660 |
-#> |.....................|    -9.223 |    -5.492 |...........|...........|
-#> |   43|     477.36674 |     1.005 |   -0.9586 |   -0.9332 |   -0.9617 |
-#> |.....................|   -0.9672 |   -0.9217 |   -0.7028 |   -0.7029 |
-#> |.....................|   -0.9362 |   -0.5954 |   -0.7323 |   -0.7170 |
-#> |.....................|   -0.6350 |   -0.7479 |...........|...........|
-#> |    U|     477.36674 |     100.5 |    -4.059 |   -0.9343 |    -2.394 |
-#> |.....................|    -4.067 |  -0.01100 |    0.8046 |   0.07427 |
-#> |.....................|    0.6567 |     2.048 |     1.474 |     1.361 |
-#> |.....................|     1.858 |     1.325 |...........|...........|
-#> |    X|     477.36674 |     100.5 |   0.01727 |    0.2821 |   0.09123 |
-#> |.....................|   0.01713 |    0.4972 |    0.8046 |   0.07427 |
-#> |.....................|    0.6567 |     2.048 |     1.474 |     1.361 |
-#> |.....................|     1.858 |     1.325 |...........|...........|
-#> |    F| Forward Diff. |    -26.86 |    -1.999 |   -0.5088 |  -0.02993 |
-#> |.....................|    -1.056 |   0.01029 |    -6.930 |    -7.943 |
-#> |.....................|     1.123 |    -10.40 |    -5.776 |    -6.354 |
-#> |.....................|    -9.032 |    -5.321 |...........|...........|
-#> |   44|     477.05158 |     1.012 |   -0.9583 |   -0.9331 |   -0.9614 |
-#> |.....................|   -0.9667 |   -0.9217 |   -0.6985 |   -0.7029 |
-#> |.....................|   -0.9357 |   -0.5841 |   -0.7296 |   -0.7125 |
-#> |.....................|   -0.6265 |   -0.7430 |...........|...........|
-#> |    U|     477.05158 |     101.2 |    -4.058 |   -0.9342 |    -2.394 |
-#> |.....................|    -4.067 |  -0.01100 |    0.8062 |   0.07427 |
-#> |.....................|    0.6570 |     2.066 |     1.477 |     1.366 |
-#> |.....................|     1.871 |     1.331 |...........|...........|
-#> |    X|     477.05158 |     101.2 |   0.01728 |    0.2821 |   0.09126 |
-#> |.....................|   0.01713 |    0.4972 |    0.8062 |   0.07427 |
-#> |.....................|    0.6570 |     2.066 |     1.477 |     1.366 |
-#> |.....................|     1.871 |     1.331 |...........|...........|
-#> |    F| Forward Diff. |     21.59 |   -0.9080 |    0.1072 |   -0.3377 |
-#> |.....................|    -1.120 |  0.008656 |    -8.076 |    -8.919 |
-#> |.....................|    0.8940 |    -10.23 |    -5.724 |    -6.385 |
-#> |.....................|    -8.830 |    -5.273 |...........|...........|
-#> |   45|     476.75116 |     1.006 |   -0.9582 |   -0.9333 |   -0.9610 |
-#> |.....................|   -0.9662 |   -0.9217 |   -0.6961 |   -0.7025 |
-#> |.....................|   -0.9353 |   -0.5723 |   -0.7265 |   -0.7076 |
-#> |.....................|   -0.6174 |   -0.7378 |...........|...........|
-#> |    U|     476.75116 |     100.6 |    -4.058 |   -0.9343 |    -2.394 |
-#> |.....................|    -4.066 |  -0.01100 |    0.8070 |   0.07428 |
-#> |.....................|    0.6573 |     2.085 |     1.481 |     1.371 |
-#> |.....................|     1.884 |     1.337 |...........|...........|
-#> |    X|     476.75116 |     100.6 |   0.01728 |    0.2820 |   0.09129 |
-#> |.....................|   0.01714 |    0.4972 |    0.8070 |   0.07428 |
-#> |.....................|    0.6573 |     2.085 |     1.481 |     1.371 |
-#> |.....................|     1.884 |     1.337 |...........|...........|
-#> |    F| Forward Diff. |    -19.26 |    -1.806 |   -0.3949 |  -0.06769 |
-#> |.....................|    -1.006 |   0.01017 |    -6.717 |    -7.715 |
-#> |.....................|     1.115 |    -9.949 |    -5.529 |    -6.080 |
-#> |.....................|    -8.599 |    -5.083 |...........|...........|
-#> |   46|     476.47529 |     1.013 |   -0.9577 |   -0.9333 |   -0.9608 |
-#> |.....................|   -0.9657 |   -0.9218 |   -0.6941 |   -0.7020 |
-#> |.....................|   -0.9354 |   -0.5606 |   -0.7233 |   -0.7027 |
-#> |.....................|   -0.6086 |   -0.7326 |...........|...........|
-#> |    U|     476.47529 |     101.3 |    -4.058 |   -0.9343 |    -2.393 |
-#> |.....................|    -4.066 |  -0.01100 |    0.8078 |   0.07430 |
-#> |.....................|    0.6573 |     2.103 |     1.485 |     1.377 |
-#> |.....................|     1.897 |     1.342 |...........|...........|
-#> |    X|     476.47529 |     101.3 |   0.01729 |    0.2820 |   0.09132 |
-#> |.....................|   0.01715 |    0.4972 |    0.8078 |   0.07430 |
-#> |.....................|    0.6573 |     2.103 |     1.485 |     1.377 |
-#> |.....................|     1.897 |     1.342 |...........|...........|
-#> |    F| Forward Diff. |     23.23 |   -0.7393 |    0.1467 |   -0.3435 |
-#> |.....................|    -1.063 |  0.008714 |    -6.650 |    -7.604 |
-#> |.....................|     1.072 |    -9.778 |    -5.421 |    -6.068 |
-#> |.....................|    -8.413 |    -5.023 |...........|...........|
-#> |   47|     476.20958 |     1.007 |   -0.9575 |   -0.9335 |   -0.9604 |
-#> |.....................|   -0.9651 |   -0.9218 |   -0.6949 |   -0.7035 |
-#> |.....................|   -0.9364 |   -0.5488 |   -0.7198 |   -0.6977 |
-#> |.....................|   -0.5996 |   -0.7274 |...........|...........|
-#> |    U|     476.20958 |     100.7 |    -4.058 |   -0.9345 |    -2.393 |
-#> |.....................|    -4.065 |  -0.01100 |    0.8075 |   0.07425 |
-#> |.....................|    0.6566 |     2.122 |     1.490 |     1.383 |
-#> |.....................|     1.910 |     1.349 |...........|...........|
-#> |    X|     476.20958 |     100.7 |   0.01729 |    0.2820 |   0.09135 |
-#> |.....................|   0.01716 |    0.4972 |    0.8075 |   0.07425 |
-#> |.....................|    0.6566 |     2.122 |     1.490 |     1.383 |
-#> |.....................|     1.910 |     1.349 |...........|...........|
-#> |    F| Forward Diff. |    -16.91 |    -1.652 |   -0.3580 |  -0.07063 |
-#> |.....................|   -0.9392 |   0.01022 |    -6.706 |    -7.708 |
-#> |.....................|    0.9788 |    -9.498 |    -5.202 |    -5.742 |
-#> |.....................|    -8.208 |    -4.851 |...........|...........|
-#> |   48|     475.96032 |     1.013 |   -0.9572 |   -0.9335 |   -0.9601 |
-#> |.....................|   -0.9647 |   -0.9218 |   -0.6944 |   -0.7034 |
-#> |.....................|   -0.9370 |   -0.5368 |   -0.7166 |   -0.6928 |
-#> |.....................|   -0.5905 |   -0.7221 |...........|...........|
-#> |    U|     475.96032 |     101.3 |    -4.057 |   -0.9346 |    -2.393 |
-#> |.....................|    -4.065 |  -0.01100 |    0.8077 |   0.07425 |
-#> |.....................|    0.6562 |     2.141 |     1.494 |     1.388 |
-#> |.....................|     1.924 |     1.355 |...........|...........|
-#> |    X|     475.96032 |     101.3 |   0.01730 |    0.2820 |   0.09138 |
-#> |.....................|   0.01717 |    0.4972 |    0.8077 |   0.07425 |
-#> |.....................|    0.6562 |     2.141 |     1.494 |     1.388 |
-#> |.....................|     1.924 |     1.355 |...........|...........|
-#> |    F| Forward Diff. |     22.21 |   -0.6469 |    0.1490 |   -0.3297 |
-#> |.....................|   -0.9912 |  0.008804 |    -6.697 |    -7.730 |
-#> |.....................|     1.011 |    -9.295 |    -5.014 |    -5.737 |
-#> |.....................|    -7.990 |    -4.768 |...........|...........|
-#> |   49|     475.69232 |     1.007 |   -0.9579 |   -0.9338 |   -0.9597 |
-#> |.....................|   -0.9645 |   -0.9219 |   -0.6939 |   -0.7032 |
-#> |.....................|   -0.9375 |   -0.5243 |   -0.7149 |   -0.6885 |
-#> |.....................|   -0.5813 |   -0.7168 |...........|...........|
-#> |    U|     475.69232 |     100.7 |    -4.058 |   -0.9348 |    -2.392 |
-#> |.....................|    -4.064 |  -0.01100 |    0.8078 |   0.07426 |
-#> |.....................|    0.6559 |     2.161 |     1.496 |     1.393 |
-#> |.....................|     1.937 |     1.361 |...........|...........|
-#> |    X|     475.69232 |     100.7 |   0.01729 |    0.2819 |   0.09141 |
-#> |.....................|   0.01717 |    0.4972 |    0.8078 |   0.07426 |
-#> |.....................|    0.6559 |     2.161 |     1.496 |     1.393 |
-#> |.....................|     1.937 |     1.361 |...........|...........|
-#> |    F| Forward Diff. |    -16.63 |    -1.703 |   -0.3428 |  -0.06069 |
-#> |.....................|   -0.9074 |   0.01024 |    -7.409 |    -9.759 |
-#> |.....................|    0.6668 |    -9.063 |    -4.970 |    -5.451 |
-#> |.....................|    -7.786 |    -4.607 |...........|...........|
-#> |   50|     475.41012 |     1.012 |   -0.9580 |   -0.9340 |   -0.9594 |
-#> |.....................|   -0.9645 |   -0.9219 |   -0.6912 |   -0.6928 |
-#> |.....................|   -0.9358 |   -0.5138 |   -0.7150 |   -0.6862 |
-#> |.....................|   -0.5743 |   -0.7128 |...........|...........|
-#> |    U|     475.41012 |     101.2 |    -4.058 |   -0.9351 |    -2.392 |
-#> |.....................|    -4.064 |  -0.01101 |    0.8088 |   0.07461 |
-#> |.....................|    0.6570 |     2.177 |     1.496 |     1.396 |
-#> |.....................|     1.948 |     1.365 |...........|...........|
-#> |    X|     475.41012 |     101.2 |   0.01728 |    0.2819 |   0.09144 |
-#> |.....................|   0.01717 |    0.4972 |    0.8088 |   0.07461 |
-#> |.....................|    0.6570 |     2.177 |     1.496 |     1.396 |
-#> |.....................|     1.948 |     1.365 |...........|...........|
-#> |    F| Forward Diff. |     17.88 |   -0.8521 |   0.09625 |   -0.2834 |
-#> |.....................|    -1.006 |  0.008928 |    -8.320 |    -8.272 |
-#> |.....................|    0.6841 |    -8.896 |    -4.958 |    -5.482 |
-#> |.....................|    -7.690 |    -4.565 |...........|...........|
-#> |   51|     475.17343 |     1.006 |   -0.9580 |   -0.9344 |   -0.9592 |
-#> |.....................|   -0.9643 |   -0.9219 |   -0.6806 |   -0.6840 |
-#> |.....................|   -0.9328 |   -0.5062 |   -0.7153 |   -0.6852 |
-#> |.....................|   -0.5694 |   -0.7102 |...........|...........|
-#> |    U|     475.17343 |     100.6 |    -4.058 |   -0.9354 |    -2.392 |
-#> |.....................|    -4.064 |  -0.01101 |    0.8127 |   0.07490 |
-#> |.....................|    0.6590 |     2.189 |     1.495 |     1.397 |
-#> |.....................|     1.955 |     1.368 |...........|...........|
-#> |    X|     475.17343 |     100.6 |   0.01728 |    0.2818 |   0.09146 |
-#> |.....................|   0.01718 |    0.4972 |    0.8127 |   0.07490 |
-#> |.....................|    0.6590 |     2.189 |     1.495 |     1.397 |
-#> |.....................|     1.955 |     1.368 |...........|...........|
-#> |    F| Forward Diff. |    -22.54 |    -1.885 |   -0.4332 | -0.003109 |
-#> |.....................|   -0.9120 |   0.01053 |    -7.129 |    -7.659 |
-#> |.....................|    0.8338 |    -8.700 |    -4.918 |    -5.365 |
-#> |.....................|    -7.558 |    -4.481 |...........|...........|
-#> |   52|     474.94312 |     1.012 |   -0.9570 |   -0.9345 |   -0.9591 |
-#> |.....................|   -0.9638 |   -0.9220 |   -0.6676 |   -0.6825 |
-#> |.....................|   -0.9307 |   -0.4984 |   -0.7146 |   -0.6834 |
-#> |.....................|   -0.5639 |   -0.7072 |...........|...........|
-#> |    U|     474.94312 |     101.2 |    -4.057 |   -0.9355 |    -2.392 |
-#> |.....................|    -4.064 |  -0.01101 |    0.8175 |   0.07495 |
-#> |.....................|    0.6604 |     2.202 |     1.496 |     1.399 |
-#> |.....................|     1.963 |     1.372 |...........|...........|
-#> |    X|     474.94312 |     101.2 |   0.01730 |    0.2818 |   0.09147 |
-#> |.....................|   0.01718 |    0.4972 |    0.8175 |   0.07495 |
-#> |.....................|    0.6604 |     2.202 |     1.496 |     1.399 |
-#> |.....................|     1.963 |     1.372 |...........|...........|
-#> |    F| Forward Diff. |     20.08 |   -0.5236 |    0.1181 |   -0.2986 |
-#> |.....................|   -0.9599 |  0.008866 |    -5.310 |    -6.088 |
-#> |.....................|    0.8565 |    -8.707 |    -4.867 |    -5.430 |
-#> |.....................|    -7.458 |    -4.464 |...........|...........|
-#> |   53|     474.70657 |     1.007 |   -0.9569 |   -0.9346 |   -0.9588 |
-#> |.....................|   -0.9629 |   -0.9220 |   -0.6640 |   -0.6851 |
-#> |.....................|   -0.9296 |   -0.4868 |   -0.7112 |   -0.6784 |
-#> |.....................|   -0.5553 |   -0.7021 |...........|...........|
-#> |    U|     474.70657 |     100.7 |    -4.057 |   -0.9356 |    -2.392 |
-#> |.....................|    -4.063 |  -0.01101 |    0.8188 |   0.07487 |
-#> |.....................|    0.6612 |     2.220 |     1.500 |     1.405 |
-#> |.....................|     1.976 |     1.378 |...........|...........|
-#> |    X|     474.70657 |     100.7 |   0.01730 |    0.2818 |   0.09149 |
-#> |.....................|   0.01720 |    0.4972 |    0.8188 |   0.07487 |
-#> |.....................|    0.6612 |     2.220 |     1.500 |     1.405 |
-#> |.....................|     1.976 |     1.378 |...........|...........|
-#> |    F| Forward Diff. |    -17.64 |    -1.502 |   -0.3627 |  -0.03824 |
-#> |.....................|   -0.7798 |   0.01049 |    -5.965 |    -8.154 |
-#> |.....................|    0.5631 |    -8.385 |    -4.675 |    -5.151 |
-#> |.....................|    -7.306 |    -4.317 |...........|...........|
-#> |   54|     474.46623 |     1.012 |   -0.9580 |   -0.9346 |   -0.9586 |
-#> |.....................|   -0.9630 |   -0.9221 |   -0.6659 |   -0.6813 |
-#> |.....................|   -0.9264 |   -0.4751 |   -0.7083 |   -0.6739 |
-#> |.....................|   -0.5464 |   -0.6970 |...........|...........|
-#> |    U|     474.46623 |     101.2 |    -4.058 |   -0.9356 |    -2.391 |
-#> |.....................|    -4.063 |  -0.01101 |    0.8181 |   0.07499 |
-#> |.....................|    0.6633 |     2.239 |     1.504 |     1.410 |
-#> |.....................|     1.989 |     1.384 |...........|...........|
-#> |    X|     474.46623 |     101.2 |   0.01728 |    0.2818 |   0.09151 |
-#> |.....................|   0.01720 |    0.4972 |    0.8181 |   0.07499 |
-#> |.....................|    0.6633 |     2.239 |     1.504 |     1.410 |
-#> |.....................|     1.989 |     1.384 |...........|...........|
-#> |    F| Forward Diff. |     15.93 |   -0.7754 |   0.09266 |   -0.2754 |
-#> |.....................|   -0.8835 |  0.009135 |    -6.026 |    -6.068 |
-#> |.....................|    0.8217 |    -8.210 |    -4.532 |    -5.141 |
-#> |.....................|    -7.011 |    -4.237 |...........|...........|
-#> |   55|     474.23394 |     1.006 |   -0.9577 |   -0.9351 |   -0.9581 |
-#> |.....................|   -0.9633 |   -0.9221 |   -0.6610 |   -0.6793 |
-#> |.....................|   -0.9234 |   -0.4633 |   -0.7068 |   -0.6694 |
-#> |.....................|   -0.5382 |   -0.6917 |...........|...........|
-#> |    U|     474.23394 |     100.6 |    -4.058 |   -0.9360 |    -2.391 |
-#> |.....................|    -4.063 |  -0.01101 |    0.8199 |   0.07506 |
-#> |.....................|    0.6654 |     2.257 |     1.506 |     1.415 |
-#> |.....................|     2.001 |     1.390 |...........|...........|
-#> |    X|     474.23394 |     100.6 |   0.01729 |    0.2817 |   0.09156 |
-#> |.....................|   0.01719 |    0.4972 |    0.8199 |   0.07506 |
-#> |.....................|    0.6654 |     2.257 |     1.506 |     1.415 |
-#> |.....................|     2.001 |     1.390 |...........|...........|
-#> |    F| Forward Diff. |    -20.30 |    -1.703 |   -0.3919 | -0.002629 |
-#> |.....................|   -0.8653 |   0.01064 |    -4.947 |    -7.765 |
-#> |.....................|    0.7818 |    -8.010 |    -4.437 |    -4.875 |
-#> |.....................|    -6.938 |    -4.094 |...........|...........|
-#> |   56|     473.98878 |     1.011 |   -0.9542 |   -0.9354 |   -0.9578 |
-#> |.....................|   -0.9619 |   -0.9222 |   -0.6621 |   -0.6770 |
-#> |.....................|   -0.9235 |   -0.4507 |   -0.7053 |   -0.6648 |
-#> |.....................|   -0.5298 |   -0.6863 |...........|...........|
-#> |    U|     473.98878 |     101.1 |    -4.054 |   -0.9363 |    -2.390 |
-#> |.....................|    -4.062 |  -0.01101 |    0.8195 |   0.07514 |
-#> |.....................|    0.6653 |     2.277 |     1.508 |     1.421 |
-#> |.....................|     2.013 |     1.396 |...........|...........|
-#> |    X|     473.98878 |     101.1 |   0.01735 |    0.2816 |   0.09159 |
-#> |.....................|   0.01722 |    0.4972 |    0.8195 |   0.07514 |
-#> |.....................|    0.6653 |     2.277 |     1.508 |     1.421 |
-#> |.....................|     2.013 |     1.396 |...........|...........|
-#> |   57|     473.76836 |     1.011 |   -0.9500 |   -0.9359 |   -0.9574 |
-#> |.....................|   -0.9601 |   -0.9223 |   -0.6653 |   -0.6763 |
-#> |.....................|   -0.9234 |   -0.4357 |   -0.7046 |   -0.6601 |
-#> |.....................|   -0.5205 |   -0.6802 |...........|...........|
-#> |    U|     473.76836 |     101.1 |    -4.050 |   -0.9368 |    -2.390 |
-#> |.....................|    -4.060 |  -0.01101 |    0.8183 |   0.07516 |
-#> |.....................|    0.6654 |     2.301 |     1.509 |     1.426 |
-#> |.....................|     2.027 |     1.403 |...........|...........|
-#> |    X|     473.76836 |     101.1 |   0.01742 |    0.2815 |   0.09163 |
-#> |.....................|   0.01725 |    0.4972 |    0.8183 |   0.07516 |
-#> |.....................|    0.6654 |     2.301 |     1.509 |     1.426 |
-#> |.....................|     2.027 |     1.403 |...........|...........|
-#> |   58|     472.96708 |     1.009 |   -0.9317 |   -0.9384 |   -0.9555 |
-#> |.....................|   -0.9527 |   -0.9228 |   -0.6791 |   -0.6735 |
-#> |.....................|   -0.9230 |   -0.3711 |   -0.7015 |   -0.6396 |
-#> |.....................|   -0.4802 |   -0.6537 |...........|...........|
-#> |    U|     472.96708 |     100.9 |    -4.032 |   -0.9391 |    -2.388 |
-#> |.....................|    -4.053 |  -0.01101 |    0.8133 |   0.07525 |
-#> |.....................|    0.6656 |     2.403 |     1.513 |     1.450 |
-#> |.....................|     2.087 |     1.433 |...........|...........|
-#> |    X|     472.96708 |     100.9 |   0.01774 |    0.2811 |   0.09180 |
-#> |.....................|   0.01737 |    0.4972 |    0.8133 |   0.07525 |
-#> |.....................|    0.6656 |     2.403 |     1.513 |     1.450 |
-#> |.....................|     2.087 |     1.433 |...........|...........|
-#> |   59|     472.23802 |     1.005 |   -0.8811 |   -0.9451 |   -0.9502 |
-#> |.....................|   -0.9323 |   -0.9240 |   -0.7172 |   -0.6658 |
-#> |.....................|   -0.9220 |   -0.1924 |   -0.6930 |   -0.5829 |
-#> |.....................|   -0.3688 |   -0.5805 |...........|...........|
-#> |    U|     472.23802 |     100.5 |    -3.981 |   -0.9455 |    -2.383 |
-#> |.....................|    -4.032 |  -0.01103 |    0.7994 |   0.07551 |
-#> |.....................|    0.6663 |     2.686 |     1.523 |     1.515 |
-#> |.....................|     2.251 |     1.518 |...........|...........|
-#> |    X|     472.23802 |     100.5 |   0.01866 |    0.2798 |   0.09228 |
-#> |.....................|   0.01773 |    0.4972 |    0.7994 |   0.07551 |
-#> |.....................|    0.6663 |     2.686 |     1.523 |     1.515 |
-#> |.....................|     2.251 |     1.518 |...........|...........|
-#> |    F| Forward Diff. |    -10.41 |     25.09 |    -1.964 |    0.8913 |
-#> |.....................|     4.956 |   0.02208 |    -7.724 |    -8.360 |
-#> |.....................|   0.01123 |    -2.619 |    -3.185 |    -1.886 |
-#> |.....................|    -3.376 |    -1.727 |...........|...........|
-#> |   60|     470.34942 |     1.020 |    -1.007 |   -0.9408 |   -0.9496 |
-#> |.....................|   -0.9429 |   -0.9259 |   -0.7397 |   -0.6282 |
-#> |.....................|   -0.9207 |   0.06578 |   -0.6693 |   -0.4998 |
-#> |.....................|   -0.2002 |   -0.4722 |...........|...........|
-#> |    U|     470.34942 |     102.0 |    -4.107 |   -0.9414 |    -2.382 |
-#> |.....................|    -4.043 |  -0.01105 |    0.7911 |   0.07677 |
-#> |.....................|    0.6672 |     3.094 |     1.553 |     1.610 |
-#> |.....................|     2.500 |     1.642 |...........|...........|
-#> |    X|     470.34942 |     102.0 |   0.01646 |    0.2806 |   0.09235 |
-#> |.....................|   0.01755 |    0.4972 |    0.7911 |   0.07677 |
-#> |.....................|    0.6672 |     3.094 |     1.553 |     1.610 |
-#> |.....................|     2.500 |     1.642 |...........|...........|
-#> |    F| Forward Diff. |     49.94 |    -17.10 |     1.872 |    -1.413 |
-#> |.....................|     4.684 |  0.005064 |    -7.591 |    -5.431 |
-#> |.....................|    0.2085 |    -2.165 |    -1.196 |   -0.1732 |
-#> |.....................|   -0.4074 |   -0.2957 |...........|...........|
-#> |   61|     480.76065 |    0.9913 |   -0.9789 |   -0.9482 |   -0.9314 |
-#> |.....................|    -1.207 |   -0.9279 |   -0.6546 |   -0.4866 |
-#> |.....................|   -0.9168 |    0.2296 |   -0.6593 |   -0.5083 |
-#> |.....................|   -0.1307 |   -0.4332 |...........|...........|
-#> |    U|     480.76065 |     99.13 |    -4.079 |   -0.9483 |    -2.364 |
-#> |.....................|    -4.307 |  -0.01107 |    0.8222 |   0.08152 |
-#> |.....................|    0.6698 |     3.353 |     1.566 |     1.601 |
-#> |.....................|     2.603 |     1.687 |...........|...........|
-#> |    X|     480.76065 |     99.13 |   0.01693 |    0.2792 |   0.09404 |
-#> |.....................|   0.01347 |    0.4972 |    0.8222 |   0.08152 |
-#> |.....................|    0.6698 |     3.353 |     1.566 |     1.601 |
-#> |.....................|     2.603 |     1.687 |...........|...........|
-#> |   62|     472.12595 |    0.9860 |   -0.9933 |   -0.9428 |   -0.9466 |
-#> |.....................|   -0.9755 |   -0.9261 |   -0.7254 |   -0.6089 |
-#> |.....................|   -0.9204 |   0.08558 |   -0.6674 |   -0.5007 |
-#> |.....................|   -0.1921 |   -0.4676 |...........|...........|
-#> |    U|     472.12595 |     98.60 |    -4.093 |   -0.9433 |    -2.379 |
-#> |.....................|    -4.076 |  -0.01105 |    0.7964 |   0.07742 |
-#> |.....................|    0.6674 |     3.125 |     1.556 |     1.609 |
-#> |.....................|     2.512 |     1.648 |...........|...........|
-#> |    X|     472.12595 |     98.60 |   0.01668 |    0.2802 |   0.09262 |
-#> |.....................|   0.01698 |    0.4972 |    0.7964 |   0.07742 |
-#> |.....................|    0.6674 |     3.125 |     1.556 |     1.609 |
-#> |.....................|     2.512 |     1.648 |...........|...........|
-#> |   63|     470.26696 |     1.005 |    -1.002 |   -0.9414 |   -0.9491 |
-#> |.....................|   -0.9444 |   -0.9259 |   -0.7373 |   -0.6265 |
-#> |.....................|   -0.9207 |   0.06646 |   -0.6689 |   -0.4998 |
-#> |.....................|   -0.2001 |   -0.4721 |...........|...........|
-#> |    U|     470.26696 |     100.5 |    -4.102 |   -0.9420 |    -2.382 |
-#> |.....................|    -4.044 |  -0.01105 |    0.7920 |   0.07683 |
-#> |.....................|    0.6672 |     3.095 |     1.554 |     1.610 |
-#> |.....................|     2.501 |     1.642 |...........|...........|
-#> |    X|     470.26696 |     100.5 |   0.01654 |    0.2805 |   0.09239 |
-#> |.....................|   0.01752 |    0.4972 |    0.7920 |   0.07683 |
-#> |.....................|    0.6672 |     3.095 |     1.554 |     1.610 |
-#> |.....................|     2.501 |     1.642 |...........|...........|
-#> |    F| Forward Diff. |    -57.97 |    -21.53 |    0.3336 |   -0.1964 |
-#> |.....................|     4.949 |   0.01388 |    -7.299 |    -5.475 |
-#> |.....................|    0.3363 |    -1.951 |    -1.200 |    0.1716 |
-#> |.....................|   -0.4705 |   -0.2755 |...........|...........|
-#> |   64|     469.85165 |     1.014 |   -0.9972 |   -0.9415 |   -0.9489 |
-#> |.....................|   -0.9548 |   -0.9260 |   -0.7307 |   -0.6235 |
-#> |.....................|   -0.9208 |   0.07069 |   -0.6682 |   -0.5004 |
-#> |.....................|   -0.1987 |   -0.4712 |...........|...........|
-#> |    U|     469.85165 |     101.4 |    -4.097 |   -0.9421 |    -2.382 |
-#> |.....................|    -4.055 |  -0.01105 |    0.7944 |   0.07693 |
-#> |.....................|    0.6671 |     3.101 |     1.555 |     1.610 |
-#> |.....................|     2.503 |     1.643 |...........|...........|
-#> |    X|     469.85165 |     101.4 |   0.01662 |    0.2805 |   0.09241 |
-#> |.....................|   0.01734 |    0.4972 |    0.7944 |   0.07693 |
-#> |.....................|    0.6671 |     3.101 |     1.555 |     1.610 |
-#> |.....................|     2.503 |     1.643 |...........|...........|
-#> |    F| Forward Diff. |     9.302 |    -15.01 |     1.055 |   -0.6015 |
-#> |.....................|     1.082 |  0.004567 |    -8.090 |    -5.650 |
-#> |.....................|   -0.2579 |    -2.336 |    -1.339 |  -0.08766 |
-#> |.....................|   -0.5208 |   -0.3062 |...........|...........|
-#> |   65|     469.69998 |     1.007 |   -0.9853 |   -0.9423 |   -0.9484 |
-#> |.....................|   -0.9564 |   -0.9260 |   -0.7231 |   -0.6186 |
-#> |.....................|   -0.9204 |   0.07309 |   -0.6671 |   -0.5006 |
-#> |.....................|   -0.1982 |   -0.4709 |...........|...........|
-#> |    U|     469.69998 |     100.7 |    -4.085 |   -0.9429 |    -2.381 |
-#> |.....................|    -4.056 |  -0.01105 |    0.7972 |   0.07709 |
-#> |.....................|    0.6674 |     3.105 |     1.556 |     1.610 |
-#> |.....................|     2.503 |     1.644 |...........|...........|
-#> |    X|     469.69998 |     100.7 |   0.01682 |    0.2803 |   0.09245 |
-#> |.....................|   0.01731 |    0.4972 |    0.7972 |   0.07709 |
-#> |.....................|    0.6674 |     3.105 |     1.556 |     1.610 |
-#> |.....................|     2.503 |     1.644 |...........|...........|
-#> |    F| Forward Diff. |    -36.86 |    -12.39 |    0.1028 |    0.1354 |
-#> |.....................|    0.7614 |  0.008951 |    -8.542 |    -6.076 |
-#> |.....................|   -0.2246 |    -2.313 |    -1.235 |    0.1010 |
-#> |.....................|   -0.5654 |   -0.2998 |...........|...........|
-#> |   66|     469.45579 |     1.013 |   -0.9821 |   -0.9425 |   -0.9491 |
-#> |.....................|   -0.9562 |   -0.9260 |   -0.7099 |   -0.6134 |
-#> |.....................|   -0.9182 |   0.07758 |   -0.6674 |   -0.5042 |
-#> |.....................|   -0.1996 |   -0.4719 |...........|...........|
-#> |    U|     469.45579 |     101.3 |    -4.082 |   -0.9430 |    -2.382 |
-#> |.....................|    -4.056 |  -0.01105 |    0.8020 |   0.07727 |
-#> |.....................|    0.6689 |     3.112 |     1.556 |     1.605 |
-#> |.....................|     2.501 |     1.643 |...........|...........|
-#> |    X|     469.45579 |     101.3 |   0.01687 |    0.2803 |   0.09239 |
-#> |.....................|   0.01731 |    0.4972 |    0.8020 |   0.07727 |
-#> |.....................|    0.6689 |     3.112 |     1.556 |     1.605 |
-#> |.....................|     2.501 |     1.643 |...........|...........|
-#> |    F| Forward Diff. |     7.383 |    -7.976 |    0.5709 |   -0.2773 |
-#> |.....................|    0.4749 |  0.005686 |    -7.013 |    -4.742 |
-#> |.....................|   -0.3037 |    -2.186 |    -1.089 |  -0.04880 |
-#> |.....................|   -0.5661 |   -0.3435 |...........|...........|
-#> |   67|     469.35718 |     1.007 |   -0.9760 |   -0.9430 |   -0.9493 |
-#> |.....................|   -0.9561 |   -0.9261 |   -0.6977 |   -0.6075 |
-#> |.....................|   -0.9166 |   0.08278 |   -0.6675 |   -0.5068 |
-#> |.....................|   -0.2001 |   -0.4722 |...........|...........|
-#> |    U|     469.35718 |     100.7 |    -4.076 |   -0.9435 |    -2.382 |
-#> |.....................|    -4.056 |  -0.01105 |    0.8065 |   0.07747 |
-#> |.....................|    0.6700 |     3.121 |     1.556 |     1.602 |
-#> |.....................|     2.501 |     1.642 |...........|...........|
-#> |    X|     469.35718 |     100.7 |   0.01698 |    0.2802 |   0.09237 |
-#> |.....................|   0.01732 |    0.4972 |    0.8065 |   0.07747 |
-#> |.....................|    0.6700 |     3.121 |     1.556 |     1.602 |
-#> |.....................|     2.501 |     1.642 |...........|...........|
-#> |    F| Forward Diff. |    -28.34 |    -7.406 |  -0.07810 |    0.1748 |
-#> |.....................|    0.6873 |  0.009156 |    -6.696 |    -4.901 |
-#> |.....................|   -0.2913 |    -2.170 |    -1.086 |  -0.02443 |
-#> |.....................|   -0.6503 |   -0.3607 |...........|...........|
-#> |   68|     469.19639 |     1.012 |   -0.9749 |   -0.9431 |   -0.9497 |
-#> |.....................|   -0.9576 |   -0.9262 |   -0.6862 |   -0.6021 |
-#> |.....................|   -0.9137 |   0.09137 |   -0.6688 |   -0.5111 |
-#> |.....................|   -0.2009 |   -0.4726 |...........|...........|
-#> |    U|     469.19639 |     101.2 |    -4.075 |   -0.9436 |    -2.382 |
-#> |.....................|    -4.058 |  -0.01105 |    0.8107 |   0.07765 |
-#> |.....................|    0.6719 |     3.134 |     1.554 |     1.597 |
-#> |.....................|     2.499 |     1.642 |...........|...........|
-#> |    X|     469.19639 |     101.2 |   0.01699 |    0.2802 |   0.09233 |
-#> |.....................|   0.01729 |    0.4972 |    0.8107 |   0.07765 |
-#> |.....................|    0.6719 |     3.134 |     1.554 |     1.597 |
-#> |.....................|     2.499 |     1.642 |...........|...........|
-#> |    F| Forward Diff. |     4.760 |    -4.629 |    0.3091 |   -0.1325 |
-#> |.....................|  -0.04401 |  0.005819 |    -5.826 |    -2.903 |
-#> |.....................|   -0.1562 |    -2.130 |    -1.121 |   -0.2535 |
-#> |.....................|   -0.6922 |   -0.4141 |...........|...........|
-#> |   69|     469.12263 |     1.008 |   -0.9713 |   -0.9434 |   -0.9499 |
-#> |.....................|   -0.9575 |   -0.9262 |   -0.6727 |   -0.6012 |
-#> |.....................|   -0.9123 |   0.09974 |   -0.6678 |   -0.5134 |
-#> |.....................|   -0.2010 |   -0.4726 |...........|...........|
-#> |    U|     469.12263 |     100.8 |    -4.071 |   -0.9438 |    -2.383 |
-#> |.....................|    -4.058 |  -0.01105 |    0.8156 |   0.07768 |
-#> |.....................|    0.6728 |     3.147 |     1.555 |     1.595 |
-#> |.....................|     2.499 |     1.642 |...........|...........|
-#> |    X|     469.12263 |     100.8 |   0.01706 |    0.2801 |   0.09232 |
-#> |.....................|   0.01729 |    0.4972 |    0.8156 |   0.07768 |
-#> |.....................|    0.6728 |     3.147 |     1.555 |     1.595 |
-#> |.....................|     2.499 |     1.642 |...........|...........|
-#> |    F| Forward Diff. |    -20.86 |    -4.532 |   -0.1251 |    0.1663 |
-#> |.....................|    0.1284 |  0.008177 |    -5.101 |    -3.487 |
-#> |.....................|   -0.2183 |    -2.137 |    -1.171 |   -0.2991 |
-#> |.....................|   -0.6817 |   -0.4261 |...........|...........|
-#> |   70|     469.02483 |     1.011 |   -0.9711 |   -0.9434 |   -0.9500 |
-#> |.....................|   -0.9569 |   -0.9263 |   -0.6616 |   -0.6038 |
-#> |.....................|   -0.9105 |    0.1111 |   -0.6656 |   -0.5157 |
-#> |.....................|   -0.2026 |   -0.4730 |...........|...........|
-#> |    U|     469.02483 |     101.1 |    -4.071 |   -0.9439 |    -2.383 |
-#> |.....................|    -4.057 |  -0.01105 |    0.8196 |   0.07759 |
-#> |.....................|    0.6741 |     3.165 |     1.558 |     1.592 |
-#> |.....................|     2.497 |     1.641 |...........|...........|
-#> |    X|     469.02483 |     101.1 |   0.01706 |    0.2801 |   0.09230 |
-#> |.....................|   0.01730 |    0.4972 |    0.8196 |   0.07759 |
-#> |.....................|    0.6741 |     3.165 |     1.558 |     1.592 |
-#> |.....................|     2.497 |     1.641 |...........|...........|
-#> |    F| Forward Diff. |     4.786 |    -2.589 |    0.2046 |   -0.1061 |
-#> |.....................|    0.1383 |  0.006373 |    -4.080 |    -2.588 |
-#> |.....................|   -0.1418 |    -1.956 |   -0.9118 |   -0.4226 |
-#> |.....................|   -0.7530 |   -0.4429 |...........|...........|
-#> |   71|     468.97618 |     1.009 |   -0.9710 |   -0.9439 |   -0.9494 |
-#> |.....................|   -0.9625 |   -0.9265 |   -0.6573 |   -0.5998 |
-#> |.....................|   -0.9085 |    0.1255 |   -0.6648 |   -0.5157 |
-#> |.....................|   -0.2015 |   -0.4719 |...........|...........|
-#> |    U|     468.97618 |     100.9 |    -4.071 |   -0.9443 |    -2.382 |
-#> |.....................|    -4.063 |  -0.01106 |    0.8212 |   0.07773 |
-#> |.....................|    0.6755 |     3.188 |     1.559 |     1.592 |
-#> |.....................|     2.498 |     1.643 |...........|...........|
-#> |    X|     468.97618 |     100.9 |   0.01706 |    0.2800 |   0.09236 |
-#> |.....................|   0.01721 |    0.4972 |    0.8212 |   0.07773 |
-#> |.....................|    0.6755 |     3.188 |     1.559 |     1.592 |
-#> |.....................|     2.498 |     1.643 |...........|...........|
-#> |    F| Forward Diff. |    -11.25 |    -3.431 |  -0.02518 |    0.1501 |
-#> |.....................|    -1.529 |  0.005347 |    -4.655 |    -3.448 |
-#> |.....................|   -0.3102 |    -2.013 |   -0.8937 |   -0.3742 |
-#> |.....................|   -0.7403 |   -0.4511 |...........|...........|
-#> |   72|     468.91299 |     1.010 |   -0.9702 |   -0.9444 |   -0.9496 |
-#> |.....................|   -0.9534 |   -0.9266 |   -0.6524 |   -0.5929 |
-#> |.....................|   -0.9051 |    0.1362 |   -0.6665 |   -0.5172 |
-#> |.....................|   -0.2029 |   -0.4725 |...........|...........|
-#> |    U|     468.91299 |     101.0 |    -4.070 |   -0.9448 |    -2.382 |
-#> |.....................|    -4.053 |  -0.01106 |    0.8230 |   0.07796 |
-#> |.....................|    0.6777 |     3.205 |     1.557 |     1.590 |
-#> |.....................|     2.496 |     1.642 |...........|...........|
-#> |    X|     468.91299 |     101.0 |   0.01707 |    0.2799 |   0.09234 |
-#> |.....................|   0.01736 |    0.4972 |    0.8230 |   0.07796 |
-#> |.....................|    0.6777 |     3.205 |     1.557 |     1.590 |
-#> |.....................|     2.496 |     1.642 |...........|...........|
-#> |    F| Forward Diff. |    -8.129 |    -2.859 |  -0.02802 | -0.004107 |
-#> |.....................|     1.281 |  0.009120 |    -4.291 |    -2.058 |
-#> |.....................|   -0.1551 |    -2.052 |    -1.121 |   -0.5699 |
-#> |.....................|   -0.7547 |   -0.4743 |...........|...........|
-#> |   73|     471.25018 |     1.036 |   -0.9607 |   -0.9443 |   -0.9496 |
-#> |.....................|   -0.9576 |   -0.9266 |   -0.6382 |   -0.5860 |
-#> |.....................|   -0.9046 |    0.1430 |   -0.6628 |   -0.5153 |
-#> |.....................|   -0.2004 |   -0.4709 |...........|...........|
-#> |    U|     471.25018 |     103.6 |    -4.061 |   -0.9447 |    -2.382 |
-#> |.....................|    -4.058 |  -0.01106 |    0.8282 |   0.07819 |
-#> |.....................|    0.6781 |     3.216 |     1.562 |     1.593 |
-#> |.....................|     2.500 |     1.644 |...........|...........|
-#> |    X|     471.25018 |     103.6 |   0.01724 |    0.2800 |   0.09234 |
-#> |.....................|   0.01729 |    0.4972 |    0.8282 |   0.07819 |
-#> |.....................|    0.6781 |     3.216 |     1.562 |     1.593 |
-#> |.....................|     2.500 |     1.644 |...........|...........|
-#> |   74|     468.90555 |     1.012 |   -0.9692 |   -0.9444 |   -0.9496 |
-#> |.....................|   -0.9538 |   -0.9266 |   -0.6510 |   -0.5922 |
-#> |.....................|   -0.9050 |    0.1369 |   -0.6661 |   -0.5170 |
-#> |.....................|   -0.2027 |   -0.4723 |...........|...........|
-#> |    U|     468.90555 |     101.2 |    -4.069 |   -0.9448 |    -2.382 |
-#> |.....................|    -4.054 |  -0.01106 |    0.8235 |   0.07798 |
-#> |.....................|    0.6778 |     3.206 |     1.557 |     1.591 |
-#> |.....................|     2.497 |     1.642 |...........|...........|
-#> |    X|     468.90555 |     101.2 |   0.01709 |    0.2799 |   0.09234 |
-#> |.....................|   0.01736 |    0.4972 |    0.8235 |   0.07798 |
-#> |.....................|    0.6778 |     3.206 |     1.557 |     1.591 |
-#> |.....................|     2.497 |     1.642 |...........|...........|
-#> |    F| Forward Diff. |     11.48 |    -1.027 |    0.1960 |   -0.1655 |
-#> |.....................|    0.9827 |  0.007474 |    -3.960 |    -2.226 |
-#> |.....................|   -0.2199 |    -2.046 |    -1.158 |   -0.6171 |
-#> |.....................|   -0.7493 |   -0.4797 |...........|...........|
-#> |   75|     468.88608 |     1.010 |   -0.9691 |   -0.9444 |   -0.9495 |
-#> |.....................|   -0.9542 |   -0.9266 |   -0.6497 |   -0.5917 |
-#> |.....................|   -0.9044 |    0.1391 |   -0.6659 |   -0.5166 |
-#> |.....................|   -0.2026 |   -0.4722 |...........|...........|
-#> |    U|     468.88608 |     101.0 |    -4.069 |   -0.9448 |    -2.382 |
-#> |.....................|    -4.054 |  -0.01106 |    0.8240 |   0.07799 |
-#> |.....................|    0.6782 |     3.210 |     1.558 |     1.591 |
-#> |.....................|     2.497 |     1.642 |...........|...........|
-#> |    X|     468.88608 |     101.0 |   0.01709 |    0.2799 |   0.09235 |
-#> |.....................|   0.01735 |    0.4972 |    0.8240 |   0.07799 |
-#> |.....................|    0.6782 |     3.210 |     1.558 |     1.591 |
-#> |.....................|     2.497 |     1.642 |...........|...........|
-#> |    F| Forward Diff. |    -2.784 |    -1.944 |  0.009889 |  -0.02065 |
-#> |.....................|    0.9781 |  0.008521 |    -3.685 |    -1.489 |
-#> |.....................|  -0.08345 |    -1.963 |   -0.9408 |   -0.4978 |
-#> |.....................|   -0.7271 |   -0.4658 |...........|...........|
-#> |   76|     468.87604 |     1.012 |   -0.9680 |   -0.9444 |   -0.9495 |
-#> |.....................|   -0.9547 |   -0.9266 |   -0.6476 |   -0.5909 |
-#> |.....................|   -0.9043 |    0.1402 |   -0.6654 |   -0.5163 |
-#> |.....................|   -0.2021 |   -0.4719 |...........|...........|
-#> |    U|     468.87604 |     101.2 |    -4.068 |   -0.9448 |    -2.382 |
-#> |.....................|    -4.055 |  -0.01106 |    0.8248 |   0.07802 |
-#> |.....................|    0.6783 |     3.211 |     1.558 |     1.591 |
-#> |.....................|     2.498 |     1.643 |...........|...........|
-#> |    X|     468.87604 |     101.2 |   0.01711 |    0.2799 |   0.09235 |
-#> |.....................|   0.01734 |    0.4972 |    0.8248 |   0.07802 |
-#> |.....................|    0.6783 |     3.211 |     1.558 |     1.591 |
-#> |.....................|     2.498 |     1.643 |...........|...........|
-#> |    F| Forward Diff. |     9.309 |   -0.5261 |    0.1314 |   -0.1053 |
-#> |.....................|    0.6891 |  0.007435 |    -3.809 |    -2.129 |
-#> |.....................|   -0.2297 |    -2.013 |    -1.108 |   -0.5855 |
-#> |.....................|   -0.7533 |   -0.4780 |...........|...........|
-#> |   77|     468.85962 |     1.010 |   -0.9680 |   -0.9444 |   -0.9495 |
-#> |.....................|   -0.9550 |   -0.9266 |   -0.6462 |   -0.5907 |
-#> |.....................|   -0.9037 |    0.1428 |   -0.6653 |   -0.5160 |
-#> |.....................|   -0.2020 |   -0.4717 |...........|...........|
-#> |    U|     468.85962 |     101.0 |    -4.068 |   -0.9448 |    -2.382 |
-#> |.....................|    -4.055 |  -0.01106 |    0.8253 |   0.07803 |
-#> |.....................|    0.6787 |     3.215 |     1.558 |     1.592 |
-#> |.....................|     2.498 |     1.643 |...........|...........|
-#> |    X|     468.85962 |     101.0 |   0.01711 |    0.2799 |   0.09235 |
-#> |.....................|   0.01734 |    0.4972 |    0.8253 |   0.07803 |
-#> |.....................|    0.6787 |     3.215 |     1.558 |     1.592 |
-#> |.....................|     2.498 |     1.643 |...........|...........|
-#> |    F| Forward Diff. |    -1.556 |    -1.258 | -0.007590 |  0.001179 |
-#> |.....................|    0.7035 |  0.008243 |    -4.446 |    -2.277 |
-#> |.....................|   -0.2406 |    -1.984 |    -1.075 |   -0.5476 |
-#> |.....................|   -0.7588 |   -0.4741 |...........|...........|
-#> |   78|     468.84535 |     1.011 |   -0.9673 |   -0.9444 |   -0.9495 |
-#> |.....................|   -0.9554 |   -0.9266 |   -0.6436 |   -0.5895 |
-#> |.....................|   -0.9036 |    0.1439 |   -0.6647 |   -0.5157 |
-#> |.....................|   -0.2016 |   -0.4714 |...........|...........|
-#> |    U|     468.84535 |     101.1 |    -4.067 |   -0.9448 |    -2.382 |
-#> |.....................|    -4.055 |  -0.01106 |    0.8262 |   0.07807 |
-#> |.....................|    0.6788 |     3.217 |     1.559 |     1.592 |
-#> |.....................|     2.498 |     1.643 |...........|...........|
-#> |    X|     468.84535 |     101.1 |   0.01712 |    0.2799 |   0.09235 |
-#> |.....................|   0.01733 |    0.4972 |    0.8262 |   0.07807 |
-#> |.....................|    0.6788 |     3.217 |     1.559 |     1.592 |
-#> |.....................|     2.498 |     1.643 |...........|...........|
-#> |    F| Forward Diff. |     5.130 |   -0.4165 |   0.05789 |  -0.04298 |
-#> |.....................|    0.5152 |  0.007618 |    -4.342 |    -2.024 |
-#> |.....................|   -0.2412 |    -1.936 |   -0.8986 |   -0.4874 |
-#> |.....................|   -0.7551 |   -0.4761 |...........|...........|
-#> |   79|     468.83559 |     1.009 |   -0.9672 |   -0.9445 |   -0.9494 |
-#> |.....................|   -0.9556 |   -0.9266 |   -0.6414 |   -0.5890 |
-#> |.....................|   -0.9032 |    0.1455 |   -0.6647 |   -0.5153 |
-#> |.....................|   -0.2012 |   -0.4711 |...........|...........|
-#> |    U|     468.83559 |     100.9 |    -4.067 |   -0.9449 |    -2.382 |
-#> |.....................|    -4.056 |  -0.01106 |    0.8270 |   0.07809 |
-#> |.....................|    0.6790 |     3.220 |     1.559 |     1.593 |
-#> |.....................|     2.499 |     1.643 |...........|...........|
-#> |    X|     468.83559 |     100.9 |   0.01713 |    0.2799 |   0.09236 |
-#> |.....................|   0.01733 |    0.4972 |    0.8270 |   0.07809 |
-#> |.....................|    0.6790 |     3.220 |     1.559 |     1.593 |
-#> |.....................|     2.499 |     1.643 |...........|...........|
-#> |    F| Forward Diff. |    -7.676 |    -1.212 |   -0.1115 |   0.08612 |
-#> |.....................|    0.5488 |  0.008589 |    -2.761 |    -2.165 |
-#> |.....................|   -0.2456 |    -1.924 |   -0.8622 |   -0.4413 |
-#> |.....................|   -0.7592 |   -0.4720 |...........|...........|
-#> |   80|     468.82320 |     1.011 |   -0.9670 |   -0.9445 |   -0.9494 |
-#> |.....................|   -0.9559 |   -0.9267 |   -0.6401 |   -0.5885 |
-#> |.....................|   -0.9025 |    0.1478 |   -0.6651 |   -0.5152 |
-#> |.....................|   -0.2008 |   -0.4708 |...........|...........|
-#> |    U|      468.8232 |     101.1 |    -4.067 |   -0.9449 |    -2.382 |
-#> |.....................|    -4.056 |  -0.01106 |    0.8275 |   0.07810 |
-#> |.....................|    0.6795 |     3.223 |     1.559 |     1.593 |
-#> |.....................|     2.499 |     1.644 |...........|...........|
-#> |    X|      468.8232 |     101.1 |   0.01713 |    0.2799 |   0.09236 |
-#> |.....................|   0.01732 |    0.4972 |    0.8275 |   0.07810 |
-#> |.....................|    0.6795 |     3.223 |     1.559 |     1.593 |
-#> |.....................|     2.499 |     1.644 |...........|...........|
-#> |    F| Forward Diff. |     5.440 |   -0.1810 |   0.05193 |  -0.03082 |
-#> |.....................|    0.3483 |  0.007438 |    -3.541 |    -1.923 |
-#> |.....................|   -0.2409 |    -1.947 |    -1.058 |   -0.5469 |
-#> |.....................|   -0.7518 |   -0.4735 |...........|...........|
-#> |   81|     468.81154 |     1.010 |   -0.9671 |   -0.9445 |   -0.9493 |
-#> |.....................|   -0.9562 |   -0.9267 |   -0.6389 |   -0.5880 |
-#> |.....................|   -0.9017 |    0.1505 |   -0.6652 |   -0.5150 |
-#> |.....................|   -0.2005 |   -0.4704 |...........|...........|
-#> |    U|     468.81154 |     101.0 |    -4.067 |   -0.9449 |    -2.382 |
-#> |.....................|    -4.056 |  -0.01106 |    0.8279 |   0.07812 |
-#> |.....................|    0.6800 |     3.228 |     1.559 |     1.593 |
-#> |.....................|     2.500 |     1.644 |...........|...........|
-#> |    X|     468.81154 |     101.0 |   0.01713 |    0.2799 |   0.09237 |
-#> |.....................|   0.01732 |    0.4972 |    0.8279 |   0.07812 |
-#> |.....................|    0.6800 |     3.228 |     1.559 |     1.593 |
-#> |.....................|     2.500 |     1.644 |...........|...........|
-#> |    F| Forward Diff. |    -2.875 |   -0.7736 |  -0.05343 |   0.05244 |
-#> |.....................|    0.3113 |  0.007978 |    -4.161 |    -2.012 |
-#> |.....................|   -0.2433 |    -1.896 |   -0.8853 |   -0.4539 |
-#> |.....................|   -0.7524 |   -0.4694 |...........|...........|
-#> |   82|     468.80001 |     1.011 |   -0.9668 |   -0.9445 |   -0.9493 |
-#> |.....................|   -0.9563 |   -0.9267 |   -0.6364 |   -0.5873 |
-#> |.....................|   -0.9013 |    0.1522 |   -0.6651 |   -0.5147 |
-#> |.....................|   -0.2001 |   -0.4701 |...........|...........|
-#> |    U|     468.80001 |     101.1 |    -4.067 |   -0.9449 |    -2.382 |
-#> |.....................|    -4.056 |  -0.01106 |    0.8288 |   0.07814 |
-#> |.....................|    0.6803 |     3.230 |     1.559 |     1.593 |
-#> |.....................|     2.501 |     1.645 |...........|...........|
-#> |    X|     468.80001 |     101.1 |   0.01713 |    0.2799 |   0.09237 |
-#> |.....................|   0.01731 |    0.4972 |    0.8288 |   0.07814 |
-#> |.....................|    0.6803 |     3.230 |     1.559 |     1.593 |
-#> |.....................|     2.501 |     1.645 |...........|...........|
-#> |    F| Forward Diff. |     6.046 |   0.03721 |   0.05257 |  -0.02595 |
-#> |.....................|    0.1943 |  0.007238 |    -2.985 |    -2.233 |
-#> |.....................|   -0.3122 |    -1.891 |   -0.9609 |   -0.5652 |
-#> |.....................|   -0.8019 |   -0.4712 |...........|...........|
-#> |   83|     468.79133 |     1.009 |   -0.9669 |   -0.9445 |   -0.9492 |
-#> |.....................|   -0.9565 |   -0.9267 |   -0.6348 |   -0.5869 |
-#> |.....................|   -0.9006 |    0.1543 |   -0.6654 |   -0.5144 |
-#> |.....................|   -0.1996 |   -0.4698 |...........|...........|
-#> |    U|     468.79133 |     100.9 |    -4.067 |   -0.9449 |    -2.382 |
-#> |.....................|    -4.056 |  -0.01106 |    0.8294 |   0.07816 |
-#> |.....................|    0.6807 |     3.234 |     1.558 |     1.594 |
-#> |.....................|     2.501 |     1.645 |...........|...........|
-#> |    X|     468.79133 |     100.9 |   0.01713 |    0.2799 |   0.09237 |
-#> |.....................|   0.01731 |    0.4972 |    0.8294 |   0.07816 |
-#> |.....................|    0.6807 |     3.234 |     1.558 |     1.594 |
-#> |.....................|     2.501 |     1.645 |...........|...........|
-#> |    F| Forward Diff. |    -7.226 |   -0.9038 |   -0.1166 |    0.1039 |
-#> |.....................|    0.2475 |  0.008246 |    -3.388 |    -1.948 |
-#> |.....................|   -0.2420 |    -1.872 |   -0.8620 |   -0.4291 |
-#> |.....................|   -0.7186 |   -0.4561 |...........|...........|
-#> |   84|     468.77848 |     1.011 |   -0.9668 |   -0.9446 |   -0.9492 |
-#> |.....................|   -0.9568 |   -0.9267 |   -0.6338 |   -0.5863 |
-#> |.....................|   -0.8997 |    0.1569 |   -0.6658 |   -0.5142 |
-#> |.....................|   -0.1992 |   -0.4695 |...........|...........|
-#> |    U|     468.77848 |     101.1 |    -4.067 |   -0.9450 |    -2.382 |
-#> |.....................|    -4.057 |  -0.01106 |    0.8298 |   0.07818 |
-#> |.....................|    0.6814 |     3.238 |     1.558 |     1.594 |
-#> |.....................|     2.502 |     1.645 |...........|...........|
-#> |    X|     468.77848 |     101.1 |   0.01713 |    0.2799 |   0.09238 |
-#> |.....................|   0.01730 |    0.4972 |    0.8298 |   0.07818 |
-#> |.....................|    0.6814 |     3.238 |     1.558 |     1.594 |
-#> |.....................|     2.502 |     1.645 |...........|...........|
-#> |    F| Forward Diff. |     2.503 |   -0.1762 |  0.005994 |   0.01651 |
-#> |.....................|   0.06327 |  0.007339 |    -4.407 |    -2.185 |
-#> |.....................|   -0.3133 |    -1.836 |   -0.8110 |   -0.4803 |
-#> |.....................|   -0.7946 |   -0.4665 |...........|...........|
-#> |   85|     468.76805 |     1.010 |   -0.9668 |   -0.9446 |   -0.9492 |
-#> |.....................|   -0.9569 |   -0.9267 |   -0.6312 |   -0.5853 |
-#> |.....................|   -0.8993 |    0.1583 |   -0.6657 |   -0.5139 |
-#> |.....................|   -0.1987 |   -0.4691 |...........|...........|
-#> |    U|     468.76805 |     101.0 |    -4.067 |   -0.9450 |    -2.382 |
-#> |.....................|    -4.057 |  -0.01106 |    0.8307 |   0.07821 |
-#> |.....................|    0.6816 |     3.240 |     1.558 |     1.594 |
-#> |.....................|     2.503 |     1.646 |...........|...........|
-#> |    X|     468.76805 |     101.0 |   0.01713 |    0.2799 |   0.09238 |
-#> |.....................|   0.01730 |    0.4972 |    0.8307 |   0.07821 |
-#> |.....................|    0.6816 |     3.240 |     1.558 |     1.594 |
-#> |.....................|     2.503 |     1.646 |...........|...........|
-#> |    F| Forward Diff. |    -5.980 |   -0.7098 |   -0.1045 |    0.1001 |
-#> |.....................|    0.1097 |  0.008007 |    -2.998 |    -1.799 |
-#> |.....................|   -0.2421 |    -1.902 |    -1.021 |   -0.4929 |
-#> |.....................|   -0.7234 |   -0.4545 |...........|...........|
-#> |   86|     468.76178 |     1.012 |   -0.9666 |   -0.9446 |   -0.9492 |
-#> |.....................|   -0.9569 |   -0.9268 |   -0.6296 |   -0.5849 |
-#> |.....................|   -0.8987 |    0.1602 |   -0.6657 |   -0.5136 |
-#> |.....................|   -0.1982 |   -0.4689 |...........|...........|
-#> |    U|     468.76178 |     101.2 |    -4.067 |   -0.9450 |    -2.382 |
-#> |.....................|    -4.057 |  -0.01106 |    0.8313 |   0.07822 |
-#> |.....................|    0.6820 |     3.243 |     1.558 |     1.595 |
-#> |.....................|     2.503 |     1.646 |...........|...........|
-#> |    X|     468.76178 |     101.2 |   0.01714 |    0.2799 |   0.09238 |
-#> |.....................|   0.01730 |    0.4972 |    0.8313 |   0.07822 |
-#> |.....................|    0.6820 |     3.243 |     1.558 |     1.595 |
-#> |.....................|     2.503 |     1.646 |...........|...........|
-#> |    F| Forward Diff. |     9.381 |    0.4945 |   0.08709 |  -0.04347 |
-#> |.....................|  -0.04178 |  0.006758 |    -3.785 |    -1.947 |
-#> |.....................|   -0.3007 |    -1.819 |   -0.8940 |   -0.4901 |
-#> |.....................|   -0.7836 |   -0.4662 |...........|...........|
-#> |   87|     468.74724 |     1.010 |   -0.9668 |   -0.9447 |   -0.9491 |
-#> |.....................|   -0.9570 |   -0.9268 |   -0.6284 |   -0.5849 |
-#> |.....................|   -0.8978 |    0.1628 |   -0.6658 |   -0.5134 |
-#> |.....................|   -0.1979 |   -0.4686 |...........|...........|
-#> |    U|     468.74724 |     101.0 |    -4.067 |   -0.9451 |    -2.382 |
-#> |.....................|    -4.057 |  -0.01106 |    0.8318 |   0.07822 |
-#> |.....................|    0.6827 |     3.247 |     1.558 |     1.595 |
-#> |.....................|     2.504 |     1.646 |...........|...........|
-#> |    X|     468.74724 |     101.0 |   0.01713 |    0.2799 |   0.09239 |
-#> |.....................|   0.01730 |    0.4972 |    0.8318 |   0.07822 |
-#> |.....................|    0.6827 |     3.247 |     1.558 |     1.595 |
-#> |.....................|     2.504 |     1.646 |...........|...........|
-#> |    F| Forward Diff. |    -1.251 |   -0.3146 |  -0.04610 |   0.05724 |
-#> |.....................|   0.02086 |  0.007590 |    -4.230 |    -2.098 |
-#> |.....................|   -0.3136 |    -1.833 |   -0.9365 |   -0.5244 |
-#> |.....................|   -0.7857 |   -0.4618 |...........|...........|
-#> |   88|     468.73570 |     1.011 |   -0.9666 |   -0.9446 |   -0.9492 |
-#> |.....................|   -0.9570 |   -0.9268 |   -0.6257 |   -0.5836 |
-#> |.....................|   -0.8976 |    0.1639 |   -0.6652 |   -0.5131 |
-#> |.....................|   -0.1974 |   -0.4683 |...........|...........|
-#> |    U|      468.7357 |     101.1 |    -4.067 |   -0.9450 |    -2.382 |
-#> |.....................|    -4.057 |  -0.01106 |    0.8327 |   0.07827 |
-#> |.....................|    0.6828 |     3.249 |     1.559 |     1.595 |
-#> |.....................|     2.504 |     1.647 |...........|...........|
-#> |    X|      468.7357 |     101.1 |   0.01714 |    0.2799 |   0.09238 |
-#> |.....................|   0.01730 |    0.4972 |    0.8327 |   0.07827 |
-#> |.....................|    0.6828 |     3.249 |     1.559 |     1.595 |
-#> |.....................|     2.504 |     1.647 |...........|...........|
-#> |    F| Forward Diff. |     4.473 |    0.2106 |   0.02342 |  0.003517 |
-#> |.....................|  -0.03354 |  0.007130 |    -3.431 |    -1.904 |
-#> |.....................|   -0.3114 |    -1.829 |   -0.9161 |   -0.5352 |
-#> |.....................|   -0.7806 |   -0.4641 |...........|...........|
-#> |   89|     468.73562 |     1.009 |   -0.9667 |   -0.9447 |   -0.9491 |
-#> |.....................|   -0.9570 |   -0.9268 |   -0.6239 |   -0.5826 |
-#> |.....................|   -0.8973 |    0.1651 |   -0.6648 |   -0.5128 |
-#> |.....................|   -0.1970 |   -0.4681 |...........|...........|
-#> |    U|     468.73562 |     100.9 |    -4.067 |   -0.9450 |    -2.382 |
-#> |.....................|    -4.057 |  -0.01106 |    0.8334 |   0.07830 |
-#> |.....................|    0.6830 |     3.251 |     1.559 |     1.596 |
-#> |.....................|     2.505 |     1.647 |...........|...........|
-#> |    X|     468.73562 |     100.9 |   0.01713 |    0.2799 |   0.09238 |
-#> |.....................|   0.01730 |    0.4972 |    0.8334 |   0.07830 |
-#> |.....................|    0.6830 |     3.251 |     1.559 |     1.596 |
-#> |.....................|     2.505 |     1.647 |...........|...........|
-#> |    C| Central Diff. |    -12.26 |    -1.176 |   -0.2138 |    0.1217 |
-#> |.....................|  -0.02157 |  0.008077 |    -2.776 |    -1.301 |
-#> |.....................|   -0.1367 |    -1.738 |   -0.7465 |   -0.4531 |
-#> |.....................|   -0.7359 |   -0.4611 |...........|...........|
-#> |   90|     468.72331 |     1.010 |   -0.9665 |   -0.9446 |   -0.9492 |
-#> |.....................|   -0.9570 |   -0.9268 |   -0.6235 |   -0.5825 |
-#> |.....................|   -0.8973 |    0.1654 |   -0.6647 |   -0.5127 |
-#> |.....................|   -0.1969 |   -0.4680 |...........|...........|
-#> |    U|     468.72331 |     101.0 |    -4.067 |   -0.9450 |    -2.382 |
-#> |.....................|    -4.057 |  -0.01106 |    0.8335 |   0.07831 |
-#> |.....................|    0.6830 |     3.251 |     1.559 |     1.596 |
-#> |.....................|     2.505 |     1.647 |...........|...........|
-#> |    X|     468.72331 |     101.0 |   0.01714 |    0.2799 |   0.09238 |
-#> |.....................|   0.01730 |    0.4972 |    0.8335 |   0.07831 |
-#> |.....................|    0.6830 |     3.251 |     1.559 |     1.596 |
-#> |.....................|     2.505 |     1.647 |...........|...........|
-#> |    F| Forward Diff. |   -0.3583 |  -0.08989 |  -0.03828 |   0.04946 |
-#> |.....................|  0.006154 |  0.007526 |    -3.405 |    -1.898 |
-#> |.....................|   -0.3214 |    -1.836 |   -0.8751 |   -0.5118 |
-#> |.....................|   -0.7778 |   -0.4622 |...........|...........|
-#> |   91|     468.71715 |     1.011 |   -0.9665 |   -0.9446 |   -0.9492 |
-#> |.....................|   -0.9570 |   -0.9268 |   -0.6223 |   -0.5817 |
-#> |.....................|   -0.8972 |    0.1661 |   -0.6643 |   -0.5125 |
-#> |.....................|   -0.1966 |   -0.4678 |...........|...........|
-#> |    U|     468.71715 |     101.1 |    -4.067 |   -0.9450 |    -2.382 |
-#> |.....................|    -4.057 |  -0.01106 |    0.8340 |   0.07833 |
-#> |.....................|    0.6831 |     3.252 |     1.560 |     1.596 |
-#> |.....................|     2.506 |     1.647 |...........|...........|
-#> |    X|     468.71715 |     101.1 |   0.01714 |    0.2799 |   0.09238 |
-#> |.....................|   0.01730 |    0.4972 |    0.8340 |   0.07833 |
-#> |.....................|    0.6831 |     3.252 |     1.560 |     1.596 |
-#> |.....................|     2.506 |     1.647 |...........|...........|
-#> |   92|     468.70862 |     1.011 |   -0.9665 |   -0.9446 |   -0.9492 |
-#> |.....................|   -0.9570 |   -0.9268 |   -0.6204 |   -0.5807 |
-#> |.....................|   -0.8970 |    0.1671 |   -0.6639 |   -0.5123 |
-#> |.....................|   -0.1962 |   -0.4676 |...........|...........|
-#> |    U|     468.70862 |     101.1 |    -4.066 |   -0.9450 |    -2.382 |
-#> |.....................|    -4.057 |  -0.01106 |    0.8347 |   0.07836 |
-#> |.....................|    0.6832 |     3.254 |     1.560 |     1.596 |
-#> |.....................|     2.506 |     1.648 |...........|...........|
-#> |    X|     468.70862 |     101.1 |   0.01714 |    0.2799 |   0.09238 |
-#> |.....................|   0.01730 |    0.4972 |    0.8347 |   0.07836 |
-#> |.....................|    0.6832 |     3.254 |     1.560 |     1.596 |
-#> |.....................|     2.506 |     1.648 |...........|...........|
-#> |   93|     468.69301 |     1.011 |   -0.9664 |   -0.9446 |   -0.9493 |
-#> |.....................|   -0.9570 |   -0.9268 |   -0.6166 |   -0.5786 |
-#> |.....................|   -0.8967 |    0.1691 |   -0.6629 |   -0.5117 |
-#> |.....................|   -0.1953 |   -0.4671 |...........|...........|
-#> |    U|     468.69301 |     101.1 |    -4.066 |   -0.9449 |    -2.382 |
-#> |.....................|    -4.057 |  -0.01106 |    0.8361 |   0.07843 |
-#> |.....................|    0.6834 |     3.257 |     1.562 |     1.597 |
-#> |.....................|     2.508 |     1.648 |...........|...........|
-#> |    X|     468.69301 |     101.1 |   0.01714 |    0.2799 |   0.09237 |
-#> |.....................|   0.01730 |    0.4972 |    0.8361 |   0.07843 |
-#> |.....................|    0.6834 |     3.257 |     1.562 |     1.597 |
-#> |.....................|     2.508 |     1.648 |...........|...........|
-#> |    F| Forward Diff. |     5.000 |    0.4463 |   0.03173 | -0.005614 |
-#> |.....................|  -0.04729 |  0.007073 |    -3.041 |    -1.513 |
-#> |.....................|   -0.3269 |    -1.766 |   -0.6347 |   -0.4208 |
-#> |.....................|   -0.7611 |   -0.4631 |...........|...........|
-#> |   94|     468.66018 |     1.011 |   -0.9666 |   -0.9442 |   -0.9484 |
-#> |.....................|   -0.9562 |   -0.9269 |   -0.6101 |   -0.5828 |
-#> |.....................|   -0.8947 |    0.1828 |   -0.6704 |   -0.5138 |
-#> |.....................|   -0.1918 |   -0.4639 |...........|...........|
-#> |    U|     468.66018 |     101.1 |    -4.067 |   -0.9446 |    -2.381 |
-#> |.....................|    -4.056 |  -0.01106 |    0.8385 |   0.07829 |
-#> |.....................|    0.6847 |     3.279 |     1.552 |     1.594 |
-#> |.....................|     2.513 |     1.652 |...........|...........|
-#> |    X|     468.66018 |     101.1 |   0.01714 |    0.2800 |   0.09245 |
-#> |.....................|   0.01731 |    0.4972 |    0.8385 |   0.07829 |
-#> |.....................|    0.6847 |     3.279 |     1.552 |     1.594 |
-#> |.....................|     2.513 |     1.652 |...........|...........|
-#> |   95|     468.61872 |     1.011 |   -0.9669 |   -0.9434 |   -0.9467 |
-#> |.....................|   -0.9547 |   -0.9271 |   -0.5984 |   -0.5914 |
-#> |.....................|   -0.8911 |    0.2086 |   -0.6849 |   -0.5181 |
-#> |.....................|   -0.1852 |   -0.4581 |...........|...........|
-#> |    U|     468.61872 |     101.1 |    -4.067 |   -0.9439 |    -2.379 |
-#> |.....................|    -4.055 |  -0.01106 |    0.8427 |   0.07801 |
-#> |.....................|    0.6872 |     3.320 |     1.534 |     1.589 |
-#> |.....................|     2.523 |     1.658 |...........|...........|
-#> |    X|     468.61872 |     101.1 |   0.01713 |    0.2801 |   0.09261 |
-#> |.....................|   0.01734 |    0.4972 |    0.8427 |   0.07801 |
-#> |.....................|    0.6872 |     3.320 |     1.534 |     1.589 |
-#> |.....................|     2.523 |     1.658 |...........|...........|
-#> |    F| Forward Diff. |     3.484 |    0.5384 |   0.08463 |   0.09865 |
-#> |.....................|    0.7055 |  0.007848 |    -2.909 |    -1.559 |
-#> |.....................|   -0.2162 |    -1.642 |    -1.728 |   -0.7121 |
-#> |.....................|   -0.5947 |   -0.3648 |...........|...........|
-#> |   96|     468.58548 |     1.008 |   -0.9690 |   -0.9515 |   -0.9524 |
-#> |.....................|   -0.9418 |   -0.9281 |   -0.5713 |   -0.6320 |
-#> |.....................|   -0.8823 |    0.2961 |   -0.6589 |   -0.5284 |
-#> |.....................|   -0.1884 |   -0.4503 |...........|...........|
-#> |    U|     468.58548 |     100.8 |    -4.069 |   -0.9515 |    -2.385 |
-#> |.....................|    -4.042 |  -0.01107 |    0.8526 |   0.07665 |
-#> |.....................|    0.6931 |     3.458 |     1.567 |     1.578 |
-#> |.....................|     2.518 |     1.667 |...........|...........|
-#> |    X|     468.58548 |     100.8 |   0.01709 |    0.2786 |   0.09208 |
-#> |.....................|   0.01757 |    0.4972 |    0.8526 |   0.07665 |
-#> |.....................|    0.6931 |     3.458 |     1.567 |     1.578 |
-#> |.....................|     2.518 |     1.667 |...........|...........|
-#> |    F| Forward Diff. |    -20.63 |    -1.258 |   -0.4941 |   -0.2790 |
-#> |.....................|     5.133 |   0.01399 |    -2.360 |    -3.936 |
-#> |.....................|  -0.04374 |    -1.146 |   -0.2901 |    -1.004 |
-#> |.....................|   -0.6864 |   -0.2503 |...........|...........|
-#> |   97|     468.42330 |     1.011 |   -0.9777 |   -0.9596 |   -0.9476 |
-#> |.....................|   -0.9583 |   -0.9295 |   -0.5827 |   -0.6211 |
-#> |.....................|   -0.8760 |    0.3979 |   -0.6632 |   -0.5247 |
-#> |.....................|   -0.1834 |   -0.4404 |...........|...........|
-#> |    U|      468.4233 |     101.1 |    -4.078 |   -0.9591 |    -2.380 |
-#> |.....................|    -4.058 |  -0.01109 |    0.8485 |   0.07701 |
-#> |.....................|    0.6974 |     3.619 |     1.561 |     1.582 |
-#> |.....................|     2.525 |     1.679 |...........|...........|
-#> |    X|      468.4233 |     101.1 |   0.01695 |    0.2771 |   0.09253 |
-#> |.....................|   0.01728 |    0.4972 |    0.8485 |   0.07701 |
-#> |.....................|    0.6974 |     3.619 |     1.561 |     1.582 |
-#> |.....................|     2.525 |     1.679 |...........|...........|
-#> |    F| Forward Diff. |    -2.203 |    -3.445 |   -0.3661 |   -0.1876 |
-#> |.....................|   -0.3413 |  0.004713 |    -2.617 |    -2.520 |
-#> |.....................|   0.09908 |   -0.8887 |   -0.1336 |   -0.9981 |
-#> |.....................|   -0.6593 |   -0.1712 |...........|...........|
-#> |   98|     468.44544 |     1.015 |   -0.9711 |   -0.9083 |   -0.9392 |
-#> |.....................|   -0.9571 |   -0.9308 |   -0.5728 |   -0.6140 |
-#> |.....................|   -0.9111 |    0.4459 |   -0.6774 |   -0.4582 |
-#> |.....................|   -0.1728 |   -0.4486 |...........|...........|
-#> |    U|     468.44544 |     101.5 |    -4.071 |   -0.9109 |    -2.372 |
-#> |.....................|    -4.057 |  -0.01110 |    0.8520 |   0.07725 |
-#> |.....................|    0.6737 |     3.695 |     1.543 |     1.658 |
-#> |.....................|     2.541 |     1.669 |...........|...........|
-#> |    X|     468.44544 |     101.5 |   0.01706 |    0.2868 |   0.09331 |
-#> |.....................|   0.01730 |    0.4972 |    0.8520 |   0.07725 |
-#> |.....................|    0.6737 |     3.695 |     1.543 |     1.658 |
-#> |.....................|     2.541 |     1.669 |...........|...........|
-#> |   99|     468.45245 |     1.016 |   -0.9696 |   -0.9377 |   -0.9438 |
-#> |.....................|   -0.9573 |   -0.9300 |   -0.5745 |   -0.6143 |
-#> |.....................|   -0.8908 |    0.4193 |   -0.6689 |   -0.4955 |
-#> |.....................|   -0.1780 |   -0.4435 |...........|...........|
-#> |    U|     468.45245 |     101.6 |    -4.070 |   -0.9385 |    -2.376 |
-#> |.....................|    -4.057 |  -0.01109 |    0.8514 |   0.07724 |
-#> |.....................|    0.6874 |     3.653 |     1.554 |     1.615 |
-#> |.....................|     2.533 |     1.675 |...........|...........|
-#> |    X|     468.45245 |     101.6 |   0.01708 |    0.2812 |   0.09288 |
-#> |.....................|   0.01730 |    0.4972 |    0.8514 |   0.07724 |
-#> |.....................|    0.6874 |     3.653 |     1.554 |     1.615 |
-#> |.....................|     2.533 |     1.675 |...........|...........|
-#> |  100|     468.50368 |     1.017 |   -0.9688 |   -0.9537 |   -0.9463 |
-#> |.....................|   -0.9573 |   -0.9296 |   -0.5755 |   -0.6144 |
-#> |.....................|   -0.8797 |    0.4047 |   -0.6643 |   -0.5158 |
-#> |.....................|   -0.1808 |   -0.4408 |...........|...........|
-#> |    U|     468.50368 |     101.7 |    -4.069 |   -0.9536 |    -2.379 |
-#> |.....................|    -4.057 |  -0.01109 |    0.8511 |   0.07724 |
-#> |.....................|    0.6949 |     3.630 |     1.560 |     1.592 |
-#> |.....................|     2.529 |     1.678 |...........|...........|
-#> |    X|     468.50368 |     101.7 |   0.01710 |    0.2782 |   0.09265 |
-#> |.....................|   0.01729 |    0.4972 |    0.8511 |   0.07724 |
-#> |.....................|    0.6949 |     3.630 |     1.560 |     1.592 |
-#> |.....................|     2.529 |     1.678 |...........|...........|
-#> |  101|     468.41664 |     1.014 |   -0.9744 |   -0.9593 |   -0.9474 |
-#> |.....................|   -0.9580 |   -0.9295 |   -0.5802 |   -0.6187 |
-#> |.....................|   -0.8761 |    0.3987 |   -0.6631 |   -0.5237 |
-#> |.....................|   -0.1828 |   -0.4402 |...........|...........|
-#> |    U|     468.41664 |     101.4 |    -4.074 |   -0.9588 |    -2.380 |
-#> |.....................|    -4.058 |  -0.01109 |    0.8494 |   0.07709 |
-#> |.....................|    0.6973 |     3.620 |     1.561 |     1.583 |
-#> |.....................|     2.526 |     1.679 |...........|...........|
-#> |    X|     468.41664 |     101.4 |   0.01700 |    0.2771 |   0.09254 |
-#> |.....................|   0.01728 |    0.4972 |    0.8494 |   0.07709 |
-#> |.....................|    0.6973 |     3.620 |     1.561 |     1.583 |
-#> |.....................|     2.526 |     1.679 |...........|...........|
-#> |    F| Forward Diff. |     15.72 |  -0.02243 |   -0.2559 |   -0.2642 |
-#> |.....................|   -0.4515 |  0.003975 |    -3.178 |    -2.839 |
-#> |.....................|  -0.02889 |   -0.8526 |   -0.3239 |    -1.069 |
-#> |.....................|   -0.6251 |   -0.1666 |...........|...........|
-#> |  102|     468.39161 |     1.011 |   -0.9744 |   -0.9571 |   -0.9468 |
-#> |.....................|   -0.9580 |   -0.9295 |   -0.5795 |   -0.6181 |
-#> |.....................|   -0.8777 |    0.4014 |   -0.6637 |   -0.5208 |
-#> |.....................|   -0.1824 |   -0.4404 |...........|...........|
-#> |    U|     468.39161 |     101.1 |    -4.074 |   -0.9567 |    -2.380 |
-#> |.....................|    -4.058 |  -0.01109 |    0.8496 |   0.07711 |
-#> |.....................|    0.6962 |     3.624 |     1.561 |     1.586 |
-#> |.....................|     2.527 |     1.679 |...........|...........|
-#> |    X|     468.39161 |     101.1 |   0.01700 |    0.2775 |   0.09260 |
-#> |.....................|   0.01728 |    0.4972 |    0.8496 |   0.07711 |
-#> |.....................|    0.6962 |     3.624 |     1.561 |     1.586 |
-#> |.....................|     2.527 |     1.679 |...........|...........|
-#> |    F| Forward Diff. |   -0.3129 |    -1.347 |   -0.3359 |  -0.08922 |
-#> |.....................|   -0.3284 |  0.005471 |    -2.643 |    -3.028 |
-#> |.....................|  -0.08821 |   -0.8778 |   -0.3083 |   -0.9349 |
-#> |.....................|   -0.6501 |   -0.1781 |...........|...........|
-#> |  103|     468.37315 |     1.012 |   -0.9728 |   -0.9567 |   -0.9467 |
-#> |.....................|   -0.9576 |   -0.9295 |   -0.5763 |   -0.6144 |
-#> |.....................|   -0.8776 |    0.4024 |   -0.6633 |   -0.5197 |
-#> |.....................|   -0.1816 |   -0.4402 |...........|...........|
-#> |    U|     468.37315 |     101.2 |    -4.073 |   -0.9564 |    -2.379 |
-#> |.....................|    -4.058 |  -0.01109 |    0.8508 |   0.07724 |
-#> |.....................|    0.6963 |     3.626 |     1.561 |     1.588 |
-#> |.....................|     2.528 |     1.679 |...........|...........|
-#> |    X|     468.37315 |     101.2 |   0.01703 |    0.2776 |   0.09261 |
-#> |.....................|   0.01729 |    0.4972 |    0.8508 |   0.07724 |
-#> |.....................|    0.6963 |     3.626 |     1.561 |     1.588 |
-#> |.....................|     2.528 |     1.679 |...........|...........|
-#> |    F| Forward Diff. |     3.643 |  -0.05906 |   -0.3284 |  -0.08464 |
-#> |.....................|   -0.2659 |  0.005628 |    -2.441 |    -2.741 |
-#> |.....................|   -0.1033 |   -0.8597 |   -0.2783 |   -0.9091 |
-#> |.....................|   -0.6423 |   -0.1835 |...........|...........|
-#> |  104|     468.35774 |     1.011 |   -0.9727 |   -0.9524 |   -0.9471 |
-#> |.....................|   -0.9577 |   -0.9297 |   -0.5762 |   -0.6128 |
-#> |.....................|   -0.8791 |    0.4096 |   -0.6644 |   -0.5136 |
-#> |.....................|   -0.1797 |   -0.4410 |...........|...........|
-#> |    U|     468.35774 |     101.1 |    -4.073 |   -0.9523 |    -2.380 |
-#> |.....................|    -4.058 |  -0.01109 |    0.8508 |   0.07729 |
-#> |.....................|    0.6953 |     3.637 |     1.560 |     1.595 |
-#> |.....................|     2.531 |     1.678 |...........|...........|
-#> |    X|     468.35774 |     101.1 |   0.01703 |    0.2784 |   0.09257 |
-#> |.....................|   0.01729 |    0.4972 |    0.8508 |   0.07729 |
-#> |.....................|    0.6953 |     3.637 |     1.560 |     1.595 |
-#> |.....................|     2.531 |     1.678 |...........|...........|
-#> |    F| Forward Diff. |    -4.235 |   -0.7549 |   -0.2072 |  -0.03117 |
-#> |.....................|   -0.2512 |  0.006470 |    -2.488 |    -2.805 |
-#> |.....................|   -0.1485 |   -0.7903 |   -0.1532 |   -0.6368 |
-#> |.....................|   -0.5813 |   -0.1871 |...........|...........|
-#> |  105|     468.34230 |     1.012 |   -0.9728 |   -0.9537 |   -0.9473 |
-#> |.....................|   -0.9580 |   -0.9300 |   -0.5748 |   -0.6111 |
-#> |.....................|   -0.8817 |    0.4177 |   -0.6661 |   -0.5086 |
-#> |.....................|   -0.1765 |   -0.4413 |...........|...........|
-#> |    U|      468.3423 |     101.2 |    -4.073 |   -0.9535 |    -2.380 |
-#> |.....................|    -4.058 |  -0.01109 |    0.8513 |   0.07735 |
-#> |.....................|    0.6935 |     3.650 |     1.558 |     1.600 |
-#> |.....................|     2.535 |     1.678 |...........|...........|
-#> |    X|      468.3423 |     101.2 |   0.01703 |    0.2782 |   0.09256 |
-#> |.....................|   0.01728 |    0.4972 |    0.8513 |   0.07735 |
-#> |.....................|    0.6935 |     3.650 |     1.558 |     1.600 |
-#> |.....................|     2.535 |     1.678 |...........|...........|
-#> |    F| Forward Diff. |     5.528 |    0.1613 |   -0.1518 |   -0.1427 |
-#> |.....................|   -0.4211 |  0.005662 |    -2.339 |    -2.549 |
-#> |.....................|   -0.1833 |   -0.8387 |   -0.3838 |   -0.5791 |
-#> |.....................|   -0.5586 |   -0.2081 |...........|...........|
-#> |  106|     468.32828 |     1.011 |   -0.9730 |   -0.9582 |   -0.9446 |
-#> |.....................|   -0.9579 |   -0.9303 |   -0.5739 |   -0.6081 |
-#> |.....................|   -0.8827 |    0.4247 |   -0.6653 |   -0.5110 |
-#> |.....................|   -0.1721 |   -0.4394 |...........|...........|
-#> |    U|     468.32828 |     101.1 |    -4.073 |   -0.9578 |    -2.377 |
-#> |.....................|    -4.058 |  -0.01110 |    0.8517 |   0.07745 |
-#> |.....................|    0.6929 |     3.661 |     1.559 |     1.598 |
-#> |.....................|     2.542 |     1.680 |...........|...........|
-#> |    X|     468.32828 |     101.1 |   0.01703 |    0.2773 |   0.09281 |
-#> |.....................|   0.01729 |    0.4972 |    0.8517 |   0.07745 |
-#> |.....................|    0.6929 |     3.661 |     1.559 |     1.598 |
-#> |.....................|     2.542 |     1.680 |...........|...........|
-#> |    F| Forward Diff. |    -1.625 |   -0.2716 |   -0.4478 |   0.07059 |
-#> |.....................|   -0.3746 |  0.006164 |    -2.097 |    -1.611 |
-#> |.....................|  -0.05708 |   -0.8042 |   -0.2658 |   -0.6338 |
-#> |.....................|   -0.5023 |   -0.1867 |...........|...........|
-#> |  107|     468.31633 |     1.012 |   -0.9727 |   -0.9524 |   -0.9447 |
-#> |.....................|   -0.9580 |   -0.9305 |   -0.5707 |   -0.6067 |
-#> |.....................|   -0.8839 |    0.4327 |   -0.6650 |   -0.5105 |
-#> |.....................|   -0.1703 |   -0.4382 |...........|...........|
-#> |    U|     468.31633 |     101.2 |    -4.073 |   -0.9523 |    -2.377 |
-#> |.....................|    -4.058 |  -0.01110 |    0.8528 |   0.07749 |
-#> |.....................|    0.6921 |     3.674 |     1.559 |     1.598 |
-#> |.....................|     2.545 |     1.681 |...........|...........|
-#> |    X|     468.31633 |     101.2 |   0.01703 |    0.2784 |   0.09280 |
-#> |.....................|   0.01728 |    0.4972 |    0.8528 |   0.07749 |
-#> |.....................|    0.6921 |     3.674 |     1.559 |     1.598 |
-#> |.....................|     2.545 |     1.681 |...........|...........|
-#> |    F| Forward Diff. |     8.853 |    0.6395 |  -0.04718 |  -0.01095 |
-#> |.....................|   -0.5142 |  0.005281 |    -1.984 |    -1.469 |
-#> |.....................|  -0.06825 |   -0.7616 |   -0.1275 |   -0.5767 |
-#> |.....................|   -0.4529 |   -0.1729 |...........|...........|
-#> |  108|     468.30195 |     1.011 |   -0.9730 |   -0.9497 |   -0.9482 |
-#> |.....................|   -0.9586 |   -0.9308 |   -0.5675 |   -0.6075 |
-#> |.....................|   -0.8868 |    0.4402 |   -0.6670 |   -0.5066 |
-#> |.....................|   -0.1704 |   -0.4381 |...........|...........|
-#> |    U|     468.30195 |     101.1 |    -4.073 |   -0.9498 |    -2.381 |
-#> |.....................|    -4.059 |  -0.01110 |    0.8540 |   0.07747 |
-#> |.....................|    0.6901 |     3.686 |     1.556 |     1.603 |
-#> |.....................|     2.544 |     1.681 |...........|...........|
-#> |    X|     468.30195 |     101.1 |   0.01703 |    0.2789 |   0.09247 |
-#> |.....................|   0.01727 |    0.4972 |    0.8540 |   0.07747 |
-#> |.....................|    0.6901 |     3.686 |     1.556 |     1.603 |
-#> |.....................|     2.544 |     1.681 |...........|...........|
-#> |    F| Forward Diff. |    -1.407 |   -0.4624 |  -0.02880 |   -0.1214 |
-#> |.....................|   -0.5499 |  0.005628 |    -1.325 |    -1.518 |
-#> |.....................|   -0.1161 |   -0.7707 |   -0.3300 |   -0.4912 |
-#> |.....................|   -0.4772 |   -0.1931 |...........|...........|
-#> |  109|     468.29210 |     1.012 |   -0.9733 |   -0.9523 |   -0.9459 |
-#> |.....................|   -0.9581 |   -0.9311 |   -0.5658 |   -0.6073 |
-#> |.....................|   -0.8878 |    0.4488 |   -0.6682 |   -0.5015 |
-#> |.....................|   -0.1697 |   -0.4385 |...........|...........|
-#> |    U|      468.2921 |     101.2 |    -4.073 |   -0.9523 |    -2.379 |
-#> |.....................|    -4.058 |  -0.01111 |    0.8546 |   0.07747 |
-#> |.....................|    0.6894 |     3.699 |     1.555 |     1.608 |
-#> |.....................|     2.546 |     1.681 |...........|...........|
-#> |    X|      468.2921 |     101.2 |   0.01702 |    0.2784 |   0.09269 |
-#> |.....................|   0.01728 |    0.4972 |    0.8546 |   0.07747 |
-#> |.....................|    0.6894 |     3.699 |     1.555 |     1.608 |
-#> |.....................|     2.546 |     1.681 |...........|...........|
-#> |  110|     468.28540 |     1.012 |   -0.9739 |   -0.9554 |   -0.9432 |
-#> |.....................|   -0.9581 |   -0.9314 |   -0.5648 |   -0.6081 |
-#> |.....................|   -0.8889 |    0.4579 |   -0.6697 |   -0.4962 |
-#> |.....................|   -0.1692 |   -0.4390 |...........|...........|
-#> |    U|      468.2854 |     101.2 |    -4.074 |   -0.9551 |    -2.376 |
-#> |.....................|    -4.058 |  -0.01111 |    0.8550 |   0.07745 |
-#> |.....................|    0.6886 |     3.714 |     1.553 |     1.615 |
-#> |.....................|     2.546 |     1.680 |...........|...........|
-#> |    X|      468.2854 |     101.2 |   0.01701 |    0.2779 |   0.09293 |
-#> |.....................|   0.01728 |    0.4972 |    0.8550 |   0.07745 |
-#> |.....................|    0.6886 |     3.714 |     1.553 |     1.615 |
-#> |.....................|     2.546 |     1.680 |...........|...........|
-#> |    F| Forward Diff. |     3.644 |   0.03668 |   -0.1986 |   0.05251 |
-#> |.....................|   -0.5265 |  0.006364 |    -2.013 |    -2.999 |
-#> |.....................|   -0.3077 |   -0.7577 |   -0.4283 |   -0.2217 |
-#> |.....................|   -0.4457 |   -0.1968 |...........|...........|
-#> |  111|     468.26285 |     1.012 |   -0.9738 |   -0.9546 |   -0.9455 |
-#> |.....................|   -0.9580 |   -0.9321 |   -0.5638 |   -0.6053 |
-#> |.....................|   -0.8894 |    0.4796 |   -0.6701 |   -0.4937 |
-#> |.....................|   -0.1665 |   -0.4375 |...........|...........|
-#> |    U|     468.26285 |     101.2 |    -4.074 |   -0.9544 |    -2.378 |
-#> |.....................|    -4.058 |  -0.01112 |    0.8554 |   0.07754 |
-#> |.....................|    0.6883 |     3.748 |     1.552 |     1.617 |
-#> |.....................|     2.550 |     1.682 |...........|...........|
-#> |    X|     468.26285 |     101.2 |   0.01701 |    0.2780 |   0.09272 |
-#> |.....................|   0.01728 |    0.4972 |    0.8554 |   0.07754 |
-#> |.....................|    0.6883 |     3.748 |     1.552 |     1.617 |
-#> |.....................|     2.550 |     1.682 |...........|...........|
-#> |  112|     468.24808 |     1.012 |   -0.9737 |   -0.9538 |   -0.9478 |
-#> |.....................|   -0.9581 |   -0.9328 |   -0.5632 |   -0.6032 |
-#> |.....................|   -0.8900 |    0.5018 |   -0.6707 |   -0.4913 |
-#> |.....................|   -0.1639 |   -0.4361 |...........|...........|
-#> |    U|     468.24808 |     101.2 |    -4.074 |   -0.9537 |    -2.380 |
-#> |.....................|    -4.058 |  -0.01113 |    0.8556 |   0.07761 |
-#> |.....................|    0.6879 |     3.783 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    X|     468.24808 |     101.2 |   0.01701 |    0.2781 |   0.09251 |
-#> |.....................|   0.01728 |    0.4972 |    0.8556 |   0.07761 |
-#> |.....................|    0.6879 |     3.783 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    F| Forward Diff. |     7.572 |    0.7442 |   -0.1004 |   -0.2485 |
-#> |.....................|   -0.5511 |  0.005645 |    -1.896 |    -1.976 |
-#> |.....................|   -0.3421 |   -0.6164 |   -0.3384 |   -0.1002 |
-#> |.....................|   -0.3637 |   -0.1858 |...........|...........|
-#> |  113|     468.24925 |     1.009 |   -0.9744 |   -0.9459 |   -0.9275 |
-#> |.....................|   -0.9570 |   -0.9342 |   -0.5606 |   -0.6003 |
-#> |.....................|   -0.8814 |    0.5390 |   -0.6664 |   -0.4916 |
-#> |.....................|   -0.1575 |   -0.4319 |...........|...........|
-#> |    U|     468.24925 |     100.9 |    -4.074 |   -0.9463 |    -2.360 |
-#> |.....................|    -4.057 |  -0.01114 |    0.8565 |   0.07771 |
-#> |.....................|    0.6937 |     3.842 |     1.557 |     1.620 |
-#> |.....................|     2.563 |     1.689 |...........|...........|
-#> |    X|     468.24925 |     100.9 |   0.01700 |    0.2796 |   0.09441 |
-#> |.....................|   0.01730 |    0.4972 |    0.8565 |   0.07771 |
-#> |.....................|    0.6937 |     3.842 |     1.557 |     1.620 |
-#> |.....................|     2.563 |     1.689 |...........|...........|
-#> |  114|     468.25666 |     1.009 |   -0.9742 |   -0.9500 |   -0.9379 |
-#> |.....................|   -0.9574 |   -0.9335 |   -0.5615 |   -0.6013 |
-#> |.....................|   -0.8858 |    0.5198 |   -0.6685 |   -0.4914 |
-#> |.....................|   -0.1608 |   -0.4340 |...........|...........|
-#> |    U|     468.25666 |     100.9 |    -4.074 |   -0.9501 |    -2.371 |
-#> |.....................|    -4.057 |  -0.01113 |    0.8562 |   0.07768 |
-#> |.....................|    0.6908 |     3.812 |     1.554 |     1.620 |
-#> |.....................|     2.559 |     1.686 |...........|...........|
-#> |    X|     468.25666 |     100.9 |   0.01701 |    0.2789 |   0.09342 |
-#> |.....................|   0.01729 |    0.4972 |    0.8562 |   0.07768 |
-#> |.....................|    0.6908 |     3.812 |     1.554 |     1.620 |
-#> |.....................|     2.559 |     1.686 |...........|...........|
-#> |  115|     468.26483 |     1.009 |   -0.9741 |   -0.9524 |   -0.9439 |
-#> |.....................|   -0.9577 |   -0.9331 |   -0.5620 |   -0.6018 |
-#> |.....................|   -0.8883 |    0.5089 |   -0.6697 |   -0.4913 |
-#> |.....................|   -0.1626 |   -0.4352 |...........|...........|
-#> |    U|     468.26483 |     100.9 |    -4.074 |   -0.9523 |    -2.377 |
-#> |.....................|    -4.058 |  -0.01113 |    0.8560 |   0.07766 |
-#> |.....................|    0.6891 |     3.794 |     1.553 |     1.620 |
-#> |.....................|     2.556 |     1.685 |...........|...........|
-#> |    X|     468.26483 |     100.9 |   0.01701 |    0.2784 |   0.09287 |
-#> |.....................|   0.01729 |    0.4972 |    0.8560 |   0.07766 |
-#> |.....................|    0.6891 |     3.794 |     1.553 |     1.620 |
-#> |.....................|     2.556 |     1.685 |...........|...........|
-#> |  116|     468.25961 |     1.009 |   -0.9740 |   -0.9538 |   -0.9477 |
-#> |.....................|   -0.9579 |   -0.9328 |   -0.5624 |   -0.6023 |
-#> |.....................|   -0.8898 |    0.5020 |   -0.6705 |   -0.4913 |
-#> |.....................|   -0.1637 |   -0.4360 |...........|...........|
-#> |    U|     468.25961 |     100.9 |    -4.074 |   -0.9536 |    -2.380 |
-#> |.....................|    -4.058 |  -0.01113 |    0.8558 |   0.07764 |
-#> |.....................|    0.6880 |     3.783 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    X|     468.25961 |     100.9 |   0.01701 |    0.2782 |   0.09252 |
-#> |.....................|   0.01729 |    0.4972 |    0.8558 |   0.07764 |
-#> |.....................|    0.6880 |     3.783 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |  117|     468.24351 |     1.011 |   -0.9738 |   -0.9538 |   -0.9477 |
-#> |.....................|   -0.9580 |   -0.9328 |   -0.5629 |   -0.6029 |
-#> |.....................|   -0.8899 |    0.5019 |   -0.6706 |   -0.4913 |
-#> |.....................|   -0.1638 |   -0.4360 |...........|...........|
-#> |    U|     468.24351 |     101.1 |    -4.074 |   -0.9537 |    -2.380 |
-#> |.....................|    -4.058 |  -0.01113 |    0.8557 |   0.07762 |
-#> |.....................|    0.6880 |     3.783 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    X|     468.24351 |     101.1 |   0.01701 |    0.2781 |   0.09252 |
-#> |.....................|   0.01728 |    0.4972 |    0.8557 |   0.07762 |
-#> |.....................|    0.6880 |     3.783 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    F| Forward Diff. |   -0.7570 |  -0.04882 |   -0.1901 |   -0.1704 |
-#> |.....................|   -0.4436 |  0.006358 |    -1.944 |    -2.069 |
-#> |.....................|   -0.3547 |   -0.6277 |   -0.2411 |  -0.07768 |
-#> |.....................|   -0.3909 |   -0.1932 |...........|...........|
-#> |  118|     468.24096 |     1.012 |   -0.9738 |   -0.9538 |   -0.9477 |
-#> |.....................|   -0.9579 |   -0.9328 |   -0.5622 |   -0.6021 |
-#> |.....................|   -0.8898 |    0.5021 |   -0.6705 |   -0.4913 |
-#> |.....................|   -0.1637 |   -0.4360 |...........|...........|
-#> |    U|     468.24096 |     101.2 |    -4.074 |   -0.9536 |    -2.380 |
-#> |.....................|    -4.058 |  -0.01113 |    0.8559 |   0.07765 |
-#> |.....................|    0.6881 |     3.784 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    X|     468.24096 |     101.2 |   0.01701 |    0.2782 |   0.09252 |
-#> |.....................|   0.01729 |    0.4972 |    0.8559 |   0.07765 |
-#> |.....................|    0.6881 |     3.784 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    F| Forward Diff. |     1.456 |    0.1549 |   -0.1619 |   -0.1892 |
-#> |.....................|   -0.4078 |  0.006267 |    -1.860 |    -2.735 |
-#> |.....................|   -0.3543 |   -0.6265 |   -0.1851 |  -0.08656 |
-#> |.....................|   -0.3612 |   -0.1856 |...........|...........|
-#> |  119|     468.23716 |     1.012 |   -0.9738 |   -0.9536 |   -0.9467 |
-#> |.....................|   -0.9576 |   -0.9329 |   -0.5614 |   -0.6008 |
-#> |.....................|   -0.8898 |    0.5037 |   -0.6704 |   -0.4911 |
-#> |.....................|   -0.1638 |   -0.4357 |...........|...........|
-#> |    U|     468.23716 |     101.2 |    -4.074 |   -0.9534 |    -2.379 |
-#> |.....................|    -4.058 |  -0.01113 |    0.8562 |   0.07769 |
-#> |.....................|    0.6881 |     3.786 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    X|     468.23716 |     101.2 |   0.01701 |    0.2782 |   0.09261 |
-#> |.....................|   0.01729 |    0.4972 |    0.8562 |   0.07769 |
-#> |.....................|    0.6881 |     3.786 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    F| Forward Diff. |     2.250 |    0.2329 |   -0.1405 |   -0.1467 |
-#> |.....................|   -0.3393 |  0.006453 |    -1.023 |    -1.889 |
-#> |.....................|   -0.3583 |   -0.6239 |   -0.2353 |  -0.09107 |
-#> |.....................|   -0.3636 |   -0.1837 |...........|...........|
-#> |  120|     468.26529 |     1.008 |   -0.9742 |   -0.9534 |   -0.9465 |
-#> |.....................|   -0.9571 |   -0.9329 |   -0.5599 |   -0.5980 |
-#> |.....................|   -0.8893 |    0.5046 |   -0.6700 |   -0.4910 |
-#> |.....................|   -0.1633 |   -0.4354 |...........|...........|
-#> |    U|     468.26529 |     100.8 |    -4.074 |   -0.9532 |    -2.379 |
-#> |.....................|    -4.057 |  -0.01113 |    0.8568 |   0.07778 |
-#> |.....................|    0.6884 |     3.788 |     1.553 |     1.621 |
-#> |.....................|     2.555 |     1.685 |...........|...........|
-#> |    X|     468.26529 |     100.8 |   0.01701 |    0.2782 |   0.09263 |
-#> |.....................|   0.01730 |    0.4972 |    0.8568 |   0.07778 |
-#> |.....................|    0.6884 |     3.788 |     1.553 |     1.621 |
-#> |.....................|     2.555 |     1.685 |...........|...........|
-#> |  121|     468.23604 |     1.011 |   -0.9739 |   -0.9535 |   -0.9467 |
-#> |.....................|   -0.9575 |   -0.9329 |   -0.5612 |   -0.6003 |
-#> |.....................|   -0.8897 |    0.5039 |   -0.6703 |   -0.4911 |
-#> |.....................|   -0.1637 |   -0.4357 |...........|...........|
-#> |    U|     468.23604 |     101.1 |    -4.074 |   -0.9534 |    -2.379 |
-#> |.....................|    -4.058 |  -0.01113 |    0.8563 |   0.07771 |
-#> |.....................|    0.6881 |     3.786 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    X|     468.23604 |     101.1 |   0.01701 |    0.2782 |   0.09261 |
-#> |.....................|   0.01729 |    0.4972 |    0.8563 |   0.07771 |
-#> |.....................|    0.6881 |     3.786 |     1.552 |     1.620 |
-#> |.....................|     2.554 |     1.684 |...........|...........|
-#> |    F| Forward Diff. |    -2.188 |   -0.1927 |   -0.1868 |   -0.1045 |
-#> |.....................|   -0.2665 |  0.006857 |    -1.024 |    -1.172 |
-#> |.....................|   -0.2153 |   -0.6125 |   -0.1502 |  -0.07921 |
-#> |.....................|   -0.3902 |   -0.1918 |...........|...........|
-#> |  122|     468.23464 |     1.012 |   -0.9738 |   -0.9534 |   -0.9465 |
-#> |.....................|   -0.9574 |   -0.9329 |   -0.5609 |   -0.6000 |
-#> |.....................|   -0.8895 |    0.5043 |   -0.6702 |   -0.4911 |
-#> |.....................|   -0.1635 |   -0.4356 |...........|...........|
-#> |    U|     468.23464 |     101.2 |    -4.074 |   -0.9533 |    -2.379 |
-#> |.....................|    -4.057 |  -0.01113 |    0.8564 |   0.07772 |
-#> |.....................|    0.6883 |     3.787 |     1.552 |     1.620 |
-#> |.....................|     2.555 |     1.684 |...........|...........|
-#> |    X|     468.23464 |     101.2 |   0.01701 |    0.2782 |   0.09263 |
-#> |.....................|   0.01729 |    0.4972 |    0.8564 |   0.07772 |
-#> |.....................|    0.6883 |     3.787 |     1.552 |     1.620 |
-#> |.....................|     2.555 |     1.684 |...........|...........|
-#> |    F| Forward Diff. |     1.857 |    0.1925 |   -0.1360 |   -0.1332 |
-#> |.....................|   -0.2859 |  0.006578 |   -0.9819 |    -1.076 |
-#> |.....................|   -0.2136 |   -0.6087 |   -0.2154 |  -0.09459 |
-#> |.....................|   -0.3609 |   -0.1836 |...........|...........|
-#> |  123|     468.23346 |     1.011 |   -0.9739 |   -0.9532 |   -0.9463 |
-#> |.....................|   -0.9574 |   -0.9329 |   -0.5607 |   -0.5998 |
-#> |.....................|   -0.8893 |    0.5049 |   -0.6701 |   -0.4911 |
-#> |.....................|   -0.1633 |   -0.4355 |...........|...........|
-#> |    U|     468.23346 |     101.1 |    -4.074 |   -0.9531 |    -2.379 |
-#> |.....................|    -4.057 |  -0.01113 |    0.8565 |   0.07772 |
-#> |.....................|    0.6884 |     3.788 |     1.552 |     1.621 |
-#> |.....................|     2.555 |     1.684 |...........|...........|
-#> |    X|     468.23346 |     101.1 |   0.01701 |    0.2783 |   0.09265 |
-#> |.....................|   0.01729 |    0.4972 |    0.8565 |   0.07772 |
-#> |.....................|    0.6884 |     3.788 |     1.552 |     1.621 |
-#> |.....................|     2.555 |     1.684 |...........|...........|
-#> |    F| Forward Diff. |    -1.112 |  -0.08635 |   -0.1600 |  -0.09176 |
-#> |.....................|   -0.2402 |  0.006873 |   -0.9941 |    -1.084 |
-#> |.....................|   -0.2133 |   -0.6080 |   -0.2006 |  -0.08423 |
-#> |.....................|   -0.3853 |   -0.1906 |...........|...........|
-#> |  124|     468.23209 |     1.012 |   -0.9738 |   -0.9531 |   -0.9461 |
-#> |.....................|   -0.9573 |   -0.9329 |   -0.5604 |   -0.5995 |
-#> |.....................|   -0.8891 |    0.5054 |   -0.6700 |   -0.4910 |
-#> |.....................|   -0.1631 |   -0.4354 |...........|...........|
-#> |    U|     468.23209 |     101.2 |    -4.074 |   -0.9530 |    -2.379 |
-#> |.....................|    -4.057 |  -0.01113 |    0.8566 |   0.07774 |
-#> |.....................|    0.6885 |     3.789 |     1.553 |     1.621 |
-#> |.....................|     2.555 |     1.685 |...........|...........|
-#> |    X|     468.23209 |     101.2 |   0.01701 |    0.2783 |   0.09266 |
-#> |.....................|   0.01730 |    0.4972 |    0.8566 |   0.07774 |
-#> |.....................|    0.6885 |     3.789 |     1.553 |     1.621 |
-#> |.....................|     2.555 |     1.685 |...........|...........|
-#> |  125|     468.23061 |     1.012 |   -0.9738 |   -0.9526 |   -0.9453 |
-#> |.....................|   -0.9573 |   -0.9330 |   -0.5604 |   -0.5995 |
-#> |.....................|   -0.8885 |    0.5071 |   -0.6698 |   -0.4911 |
-#> |.....................|   -0.1626 |   -0.4353 |...........|...........|
-#> |    U|     468.23061 |     101.2 |    -4.074 |   -0.9525 |    -2.378 |
-#> |.....................|    -4.057 |  -0.01113 |    0.8566 |   0.07773 |
-#> |.....................|    0.6889 |     3.791 |     1.553 |     1.620 |
-#> |.....................|     2.556 |     1.685 |...........|...........|
-#> |    X|     468.23061 |     101.2 |   0.01701 |    0.2784 |   0.09274 |
-#> |.....................|   0.01730 |    0.4972 |    0.8566 |   0.07773 |
-#> |.....................|    0.6889 |     3.791 |     1.553 |     1.620 |
-#> |.....................|     2.556 |     1.685 |...........|...........|
-#> |  126|     468.22552 |     1.012 |   -0.9738 |   -0.9506 |   -0.9419 |
-#> |.....................|   -0.9573 |   -0.9333 |   -0.5606 |   -0.5998 |
-#> |.....................|   -0.8861 |    0.5138 |   -0.6689 |   -0.4912 |
-#> |.....................|   -0.1606 |   -0.4347 |...........|...........|
-#> |    U|     468.22552 |     101.2 |    -4.074 |   -0.9506 |    -2.375 |
-#> |.....................|    -4.057 |  -0.01113 |    0.8565 |   0.07773 |
-#> |.....................|    0.6906 |     3.802 |     1.554 |     1.620 |
-#> |.....................|     2.559 |     1.685 |...........|...........|
-#> |    X|     468.22552 |     101.2 |   0.01701 |    0.2788 |   0.09305 |
-#> |.....................|   0.01730 |    0.4972 |    0.8565 |   0.07773 |
-#> |.....................|    0.6906 |     3.802 |     1.554 |     1.620 |
-#> |.....................|     2.559 |     1.685 |...........|...........|
-#> |  127|     468.21689 |     1.012 |   -0.9737 |   -0.9426 |   -0.9286 |
-#> |.....................|   -0.9574 |   -0.9344 |   -0.5614 |   -0.6009 |
-#> |.....................|   -0.8763 |    0.5405 |   -0.6653 |   -0.4919 |
-#> |.....................|   -0.1525 |   -0.4325 |...........|...........|
-#> |    U|     468.21689 |     101.2 |    -4.074 |   -0.9431 |    -2.361 |
-#> |.....................|    -4.057 |  -0.01114 |    0.8562 |   0.07769 |
-#> |.....................|    0.6972 |     3.844 |     1.558 |     1.620 |
-#> |.....................|     2.571 |     1.688 |...........|...........|
-#> |    X|     468.21689 |     101.2 |   0.01701 |    0.2803 |   0.09430 |
-#> |.....................|   0.01729 |    0.4972 |    0.8562 |   0.07769 |
-#> |.....................|    0.6972 |     3.844 |     1.558 |     1.620 |
-#> |.....................|     2.571 |     1.688 |...........|...........|
-#> |    F| Forward Diff. |     1.525 |    0.5842 |    0.4183 |    0.9468 |
-#> |.....................|   -0.5439 |  0.008618 |    -1.874 |    -1.936 |
-#> |.....................|   -0.2463 |   -0.5498 |   0.04440 |   -0.1490 |
-#> |.....................|   -0.2038 |   -0.1015 |...........|...........|
-#> |  128|     468.19158 |     1.011 |   -0.9737 |   -0.9504 |   -0.9293 |
-#> |.....................|   -0.9577 |   -0.9362 |   -0.5600 |   -0.6009 |
-#> |.....................|   -0.8523 |    0.5756 |   -0.6644 |   -0.4878 |
-#> |.....................|   -0.1417 |   -0.4298 |...........|...........|
-#> |    U|     468.19158 |     101.1 |    -4.074 |   -0.9504 |    -2.362 |
-#> |.....................|    -4.058 |  -0.01116 |    0.8567 |   0.07769 |
-#> |.....................|    0.7134 |     3.900 |     1.560 |     1.624 |
-#> |.....................|     2.587 |     1.691 |...........|...........|
-#> |    X|     468.19158 |     101.1 |   0.01701 |    0.2788 |   0.09423 |
-#> |.....................|   0.01729 |    0.4972 |    0.8567 |   0.07769 |
-#> |.....................|    0.7134 |     3.900 |     1.560 |     1.624 |
-#> |.....................|     2.587 |     1.691 |...........|...........|
-#> |    F| Forward Diff. |    -7.990 |    0.8226 |  -0.02734 |    0.9308 |
-#> |.....................|   -0.6358 |  0.008756 |    -3.089 |    -2.706 |
-#> |.....................|  -0.08468 |   -0.5047 |    0.1760 |  -0.08785 |
-#> |.....................|  -0.06839 |  -0.06706 |...........|...........|
-#> |  129|     468.16872 |     1.012 |   -0.9746 |   -0.9536 |   -0.9297 |
-#> |.....................|   -0.9583 |   -0.9383 |   -0.5551 |   -0.6021 |
-#> |.....................|   -0.8428 |    0.6190 |   -0.6652 |   -0.4874 |
-#> |.....................|   -0.1424 |   -0.4276 |...........|...........|
-#> |    U|     468.16872 |     101.2 |    -4.075 |   -0.9534 |    -2.362 |
-#> |.....................|    -4.058 |  -0.01118 |    0.8585 |   0.07765 |
-#> |.....................|    0.7198 |     3.968 |     1.559 |     1.625 |
-#> |.....................|     2.586 |     1.694 |...........|...........|
-#> |    X|     468.16872 |     101.2 |   0.01700 |    0.2782 |   0.09420 |
-#> |.....................|   0.01728 |    0.4972 |    0.8585 |   0.07765 |
-#> |.....................|    0.7198 |     3.968 |     1.559 |     1.625 |
-#> |.....................|     2.586 |     1.694 |...........|...........|
-#> |    F| Forward Diff. |     1.949 |     1.224 |  -0.09904 |    0.8335 |
-#> |.....................|   -0.8902 |  0.008091 |    -1.732 |    -1.975 |
-#> |.....................|  -0.02618 |   -0.4349 |    0.2067 |   -0.1419 |
-#> |.....................|  -0.09587 |  -0.05531 |...........|...........|
-#> |  130|     468.14579 |     1.011 |   -0.9759 |   -0.9465 |   -0.9356 |
-#> |.....................|   -0.9575 |   -0.9407 |   -0.5519 |   -0.5999 |
-#> |.....................|   -0.8420 |    0.6626 |   -0.6664 |   -0.4855 |
-#> |.....................|   -0.1418 |   -0.4273 |...........|...........|
-#> |    U|     468.14579 |     101.1 |    -4.076 |   -0.9467 |    -2.368 |
-#> |.....................|    -4.057 |  -0.01121 |    0.8597 |   0.07772 |
-#> |.....................|    0.7204 |     4.037 |     1.557 |     1.627 |
-#> |.....................|     2.587 |     1.694 |...........|...........|
-#> |    X|     468.14579 |     101.1 |   0.01698 |    0.2795 |   0.09364 |
-#> |.....................|   0.01729 |    0.4972 |    0.8597 |   0.07772 |
-#> |.....................|    0.7204 |     4.037 |     1.557 |     1.627 |
-#> |.....................|     2.587 |     1.694 |...........|...........|
-#> |    F| Forward Diff. |    -9.402 |   -0.5832 |    0.1847 |    0.5188 |
-#> |.....................|   -0.4155 |  0.008564 |    -1.671 |    -1.980 |
-#> |.....................|  -0.03632 |   -0.3649 |    0.3304 |  -0.09551 |
-#> |.....................|   -0.1039 |  -0.08698 |...........|...........|
-#> |  131|     468.12514 |     1.011 |   -0.9763 |   -0.9445 |   -0.9403 |
-#> |.....................|   -0.9555 |   -0.9442 |   -0.5537 |   -0.5953 |
-#> |.....................|   -0.8391 |    0.7059 |   -0.6668 |   -0.4805 |
-#> |.....................|   -0.1376 |   -0.4223 |...........|...........|
-#> |    U|     468.12514 |     101.1 |    -4.076 |   -0.9449 |    -2.373 |
-#> |.....................|    -4.056 |  -0.01125 |    0.8590 |   0.07788 |
-#> |.....................|    0.7223 |     4.106 |     1.557 |     1.633 |
-#> |.....................|     2.593 |     1.700 |...........|...........|
-#> |    X|     468.12514 |     101.1 |   0.01697 |    0.2799 |   0.09320 |
-#> |.....................|   0.01733 |    0.4972 |    0.8590 |   0.07788 |
-#> |.....................|    0.7223 |     4.106 |     1.557 |     1.633 |
-#> |.....................|     2.593 |     1.700 |...........|...........|
-#> |    F| Forward Diff. |    -5.823 |   -0.4010 |    0.3316 |    0.1628 |
-#> |.....................|    0.2993 |  0.008766 |    -1.373 |    -1.049 |
-#> |.....................|  0.008284 |   -0.3402 |    0.4029 |   0.04088 |
-#> |.....................|  -0.03436 |  -0.04680 |...........|...........|
-#> |  132|     468.10920 |     1.012 |   -0.9773 |   -0.9503 |   -0.9395 |
-#> |.....................|   -0.9556 |   -0.9476 |   -0.5516 |   -0.5942 |
-#> |.....................|   -0.8420 |    0.7499 |   -0.6684 |   -0.4836 |
-#> |.....................|   -0.1347 |   -0.4216 |...........|...........|
-#> |    U|      468.1092 |     101.2 |    -4.077 |   -0.9504 |    -2.372 |
-#> |.....................|    -4.056 |  -0.01129 |    0.8598 |   0.07791 |
-#> |.....................|    0.7204 |     4.175 |     1.555 |     1.629 |
-#> |.....................|     2.597 |     1.700 |...........|...........|
-#> |    X|      468.1092 |     101.2 |   0.01695 |    0.2788 |   0.09328 |
-#> |.....................|   0.01732 |    0.4972 |    0.8598 |   0.07791 |
-#> |.....................|    0.7204 |     4.175 |     1.555 |     1.629 |
-#> |.....................|     2.597 |     1.700 |...........|...........|
-#> |    F| Forward Diff. |    0.4262 |  -0.09925 |    0.1213 |    0.1364 |
-#> |.....................|    0.2200 |  0.008054 |   -0.8480 |   -0.9224 |
-#> |.....................|  0.002683 |   -0.2932 |    0.3866 |  -0.06974 |
-#> |.....................|   0.01820 |  -0.05063 |...........|...........|
-#> |  133|     468.09766 |     1.011 |   -0.9774 |   -0.9506 |   -0.9392 |
-#> |.....................|   -0.9564 |   -0.9508 |   -0.5497 |   -0.5929 |
-#> |.....................|   -0.8318 |    0.7901 |   -0.6724 |   -0.4776 |
-#> |.....................|   -0.1474 |   -0.4133 |...........|...........|
-#> |    U|     468.09766 |     101.1 |    -4.077 |   -0.9507 |    -2.372 |
-#> |.....................|    -4.056 |  -0.01132 |    0.8605 |   0.07796 |
-#> |.....................|    0.7273 |     4.239 |     1.550 |     1.636 |
-#> |.....................|     2.578 |     1.710 |...........|...........|
-#> |    X|     468.09766 |     101.1 |   0.01695 |    0.2788 |   0.09331 |
-#> |.....................|   0.01731 |    0.4972 |    0.8605 |   0.07796 |
-#> |.....................|    0.7273 |     4.239 |     1.550 |     1.636 |
-#> |.....................|     2.578 |     1.710 |...........|...........|
-#> |    F| Forward Diff. |    -1.610 |   0.04645 |   0.08092 |    0.1870 |
-#> |.....................|   -0.1143 |  0.008788 |   -0.7906 |   -0.9380 |
-#> |.....................|   0.03576 |   -0.2567 |    0.2790 |   0.04583 |
-#> |.....................|   -0.1853 |   0.03622 |...........|...........|
-#> |  134|     468.08577 |     1.011 |   -0.9779 |   -0.9521 |   -0.9394 |
-#> |.....................|   -0.9569 |   -0.9550 |   -0.5484 |   -0.5900 |
-#> |.....................|   -0.8316 |    0.8332 |   -0.6752 |   -0.4781 |
-#> |.....................|   -0.1428 |   -0.4231 |...........|...........|
-#> |    U|     468.08577 |     101.1 |    -4.078 |   -0.9520 |    -2.372 |
-#> |.....................|    -4.057 |  -0.01137 |    0.8610 |   0.07805 |
-#> |.....................|    0.7274 |     4.307 |     1.546 |     1.635 |
-#> |.....................|     2.585 |     1.699 |...........|...........|
-#> |    X|     468.08577 |     101.1 |   0.01694 |    0.2785 |   0.09329 |
-#> |.....................|   0.01730 |    0.4972 |    0.8610 |   0.07805 |
-#> |.....................|    0.7274 |     4.307 |     1.546 |     1.635 |
-#> |.....................|     2.585 |     1.699 |...........|...........|
-#> |    F| Forward Diff. |    -2.835 |  -0.08271 |   0.01028 |    0.1502 |
-#> |.....................|   -0.2859 |  0.008536 |   -0.7298 |   -0.7597 |
-#> |.....................|   0.09519 |   -0.2281 |    0.1720 |  -0.01715 |
-#> |.....................|   -0.1386 |   -0.1062 |...........|...........|
-#> |  135|     468.06947 |     1.011 |   -0.9795 |   -0.9573 |   -0.9407 |
-#> |.....................|   -0.9575 |   -0.9652 |   -0.5443 |   -0.5834 |
-#> |.....................|   -0.8515 |    0.9153 |   -0.6785 |   -0.4834 |
-#> |.....................|   -0.1291 |   -0.4003 |...........|...........|
-#> |    U|     468.06947 |     101.1 |    -4.080 |   -0.9569 |    -2.373 |
-#> |.....................|    -4.057 |  -0.01148 |    0.8625 |   0.07827 |
-#> |.....................|    0.7139 |     4.437 |     1.542 |     1.629 |
-#> |.....................|     2.605 |     1.725 |...........|...........|
-#> |    X|     468.06947 |     101.1 |   0.01692 |    0.2775 |   0.09316 |
-#> |.....................|   0.01729 |    0.4971 |    0.8625 |   0.07827 |
-#> |.....................|    0.7139 |     4.437 |     1.542 |     1.629 |
-#> |.....................|     2.605 |     1.725 |...........|...........|
-#> |    F| Forward Diff. |    -3.887 |   -0.6407 |   -0.1939 |   0.08469 |
-#> |.....................|   -0.4208 |  0.006503 |    -1.301 |    -1.072 |
-#> |.....................|   -0.1255 |   -0.1861 |    0.1431 |  -0.06050 |
-#> |.....................|   0.01658 |    0.1111 |...........|...........|
-#> |  136|     468.05012 |     1.012 |   -0.9812 |   -0.9547 |   -0.9420 |
-#> |.....................|   -0.9570 |   -0.9873 |   -0.5356 |   -0.5736 |
-#> |.....................|   -0.8556 |     1.092 |   -0.6884 |   -0.4796 |
-#> |.....................|   -0.1211 |   -0.3873 |...........|...........|
-#> |    U|     468.05012 |     101.2 |    -4.081 |   -0.9544 |    -2.375 |
-#> |.....................|    -4.057 |  -0.01172 |    0.8656 |   0.07860 |
-#> |.....................|    0.7112 |     4.716 |     1.529 |     1.634 |
-#> |.....................|     2.617 |     1.740 |...........|...........|
-#> |    X|     468.05012 |     101.2 |   0.01689 |    0.2780 |   0.09305 |
-#> |.....................|   0.01730 |    0.4971 |    0.8656 |   0.07860 |
-#> |.....................|    0.7112 |     4.716 |     1.529 |     1.634 |
-#> |.....................|     2.617 |     1.740 |...........|...........|
-#> |    F| Forward Diff. |     2.331 |   -0.3124 |   0.04539 |  -0.09325 |
-#> |.....................|   -0.3359 |  0.005628 |   -0.9294 |   -0.4404 |
-#> |.....................|   -0.1788 |   -0.1003 |   -0.1180 |  -0.02636 |
-#> |.....................|   0.09915 |    0.1820 |...........|...........|
-#> |  137|     468.05341 |     1.012 |   -0.9836 |   -0.9687 |   -0.9317 |
-#> |.....................|   -0.9507 |    -1.013 |   -0.5235 |   -0.5660 |
-#> |.....................|   -0.8472 |     1.268 |   -0.6904 |   -0.4754 |
-#> |.....................|   -0.1200 |   -0.3857 |...........|...........|
-#> |    U|     468.05341 |     101.2 |    -4.084 |   -0.9676 |    -2.364 |
-#> |.....................|    -4.051 |  -0.01201 |    0.8700 |   0.07886 |
-#> |.....................|    0.7168 |     4.995 |     1.527 |     1.639 |
-#> |.....................|     2.619 |     1.742 |...........|...........|
-#> |    X|     468.05341 |     101.2 |   0.01685 |    0.2754 |   0.09401 |
-#> |.....................|   0.01741 |    0.4970 |    0.8700 |   0.07886 |
-#> |.....................|    0.7168 |     4.995 |     1.527 |     1.639 |
-#> |.....................|     2.619 |     1.742 |...........|...........|
-#> |  138|     468.05012 |     1.012 |   -0.9812 |   -0.9547 |   -0.9420 |
-#> |.....................|   -0.9570 |   -0.9873 |   -0.5356 |   -0.5736 |
-#> |.....................|   -0.8556 |     1.092 |   -0.6884 |   -0.4796 |
-#> |.....................|   -0.1211 |   -0.3873 |...........|...........|
-#> |    U|     468.05012 |     101.2 |    -4.081 |   -0.9544 |    -2.375 |
-#> |.....................|    -4.057 |  -0.01172 |    0.8656 |   0.07860 |
-#> |.....................|    0.7112 |     4.716 |     1.529 |     1.634 |
-#> |.....................|     2.617 |     1.740 |...........|...........|
-#> |    X|     468.05012 |     101.2 |   0.01689 |    0.2780 |   0.09305 |
-#> |.....................|   0.01730 |    0.4971 |    0.8656 |   0.07860 |
-#> |.....................|    0.7112 |     4.716 |     1.529 |     1.634 |
-#> |.....................|     2.617 |     1.740 |...........|...........|
-#> calculating covariance matrix
-#> done
-#> Calculating residuals/tables
-#> done
-AIC(f_nlmixr_dfop_sfo_saem$nm, f_nlmixr_dfop_sfo_focei$nm)
-#> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)
-#> 
-#>                            df       AIC
-#> f_nlmixr_dfop_sfo_saem$nm  16 1105.3725
-#> f_nlmixr_dfop_sfo_focei$nm 14  810.3271
-summary(f_nlmixr_dfop_sfo_sfo, data = TRUE)
-#> Error in h(simpleError(msg, call)): error in evaluating the argument 'object' in selecting a method for function 'summary': object 'f_nlmixr_dfop_sfo_sfo' not found
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.2.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/summary.saem.mmkin.html b/docs/dev/reference/summary.saem.mmkin.html deleted file mode 100644 index e434ad8d..00000000 --- a/docs/dev/reference/summary.saem.mmkin.html +++ /dev/null @@ -1,677 +0,0 @@ - -Summary method for class "saem.mmkin" — summary.saem.mmkin • mkin - - -
-
- - - -
-
-
-

Summary method for class "saem.mmkin"

- Source: R/summary.saem.mmkin.R - -
- -
-

Lists model equations, initial parameter values, optimised parameters -for fixed effects (population), random effects (deviations from the -population mean) and residual error model, as well as the resulting -endpoints such as formation fractions and DT50 values. Optionally -(default is FALSE), the data are listed in full.

-
- -
- 
# S3 method for saem.mmkin
-summary(
-  object,
-  data = FALSE,
-  verbose = FALSE,
-  covariates = NULL,
-  covariate_quantile = 0.5,
-  distimes = TRUE,
-  ...
-)
-
-# S3 method for summary.saem.mmkin
-print(x, digits = max(3, getOption("digits") - 3), verbose = x$verbose, ...)
-
- -
-

Arguments

-
object
-

an object of class saem.mmkin

- - -
data
-

logical, indicating whether the full data should be included in -the summary.

- - -
verbose
-

Should the summary be verbose?

- - -
covariates
-

Numeric vector with covariate values for all variables in -any covariate models in the object. If given, it overrides 'covariate_quantile'.

- - -
covariate_quantile
-

This argument only has an effect if the fitted -object has covariate models. If so, the default is to show endpoints -for the median of the covariate values (50th percentile).

- - -
distimes
-

logical, indicating whether DT50 and DT90 values should be -included.

- - -
...
-

optional arguments passed to methods like print.

- - -
x
-

an object of class summary.saem.mmkin

- - -
digits
-

Number of digits to use for printing

- -
-
-

Value

- - -

The summary function returns a list based on the saemix::SaemixObject

- - -

obtained in the fit, with at least the following additional components

-
saemixversion, mkinversion, Rversion
-

The saemix, mkin and R versions used

- -
date.fit, date.summary
-

The dates where the fit and the summary were -produced

- -
diffs
-

The differential equations used in the degradation model

- -
use_of_ff
-

Was maximum or minimum use made of formation fractions

- -
data
-

The data

- -
confint_trans
-

Transformed parameters as used in the optimisation, with confidence intervals

- -
confint_back
-

Backtransformed parameters, with confidence intervals if available

- -
confint_errmod
-

Error model parameters with confidence intervals

- -
ff
-

The estimated formation fractions derived from the fitted -model.

- -
distimes
-

The DT50 and DT90 values for each observed variable.

- -
SFORB
-

If applicable, eigenvalues of SFORB components of the model.

- -

The print method is called for its side effect, i.e. printing the summary.

-
-
-

Author

-

Johannes Ranke for the mkin specific parts -saemix authors for the parts inherited from saemix.

-
- -
-

Examples

- 
# Generate five datasets following DFOP-SFO kinetics
-sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-dfop_sfo <- mkinmod(parent = mkinsub("DFOP", "m1"),
- m1 = mkinsub("SFO"), quiet = TRUE)
-set.seed(1234)
-k1_in <- rlnorm(5, log(0.1), 0.3)
-k2_in <- rlnorm(5, log(0.02), 0.3)
-g_in <- plogis(rnorm(5, qlogis(0.5), 0.3))
-f_parent_to_m1_in <- plogis(rnorm(5, qlogis(0.3), 0.3))
-k_m1_in <- rlnorm(5, log(0.02), 0.3)
-
-pred_dfop_sfo <- function(k1, k2, g, f_parent_to_m1, k_m1) {
-  mkinpredict(dfop_sfo,
-    c(k1 = k1, k2 = k2, g = g, f_parent_to_m1 = f_parent_to_m1, k_m1 = k_m1),
-    c(parent = 100, m1 = 0),
-    sampling_times)
-}
-
-ds_mean_dfop_sfo <- lapply(1:5, function(i) {
-  mkinpredict(dfop_sfo,
-    c(k1 = k1_in[i], k2 = k2_in[i], g = g_in[i],
-      f_parent_to_m1 = f_parent_to_m1_in[i], k_m1 = k_m1_in[i]),
-    c(parent = 100, m1 = 0),
-    sampling_times)
-})
-names(ds_mean_dfop_sfo) <- paste("ds", 1:5)
-
-ds_syn_dfop_sfo <- lapply(ds_mean_dfop_sfo, function(ds) {
-  add_err(ds,
-    sdfunc = function(value) sqrt(1^2 + value^2 * 0.07^2),
-    n = 1)[[1]]
-})
-
-# \dontrun{
-# Evaluate using mmkin and saem
-f_mmkin_dfop_sfo <- mmkin(list(dfop_sfo), ds_syn_dfop_sfo,
-  quiet = TRUE, error_model = "tc", cores = 5)
-f_saem_dfop_sfo <- saem(f_mmkin_dfop_sfo)
-print(f_saem_dfop_sfo)
-#> Kinetic nonlinear mixed-effects model fit by SAEM
-#> Structural model:
-#> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
-#>            time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
-#>            * parent
-#> d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)
-#>            * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *
-#>            exp(-k2 * time))) * parent - k_m1 * m1
-#> 
-#> Data:
-#> 171 observations of 2 variable(s) grouped in 5 datasets
-#> 
-#> Likelihood computed by importance sampling
-#>     AIC   BIC logLik
-#>   810.8 805.4 -391.4
-#> 
-#> Fitted parameters:
-#>                     estimate     lower     upper
-#> parent_0           100.86947  97.81542 103.92353
-#> log_k_m1            -4.06947  -4.16944  -3.96950
-#> f_parent_qlogis     -0.93256  -1.34200  -0.52312
-#> log_k1              -2.37017  -2.72660  -2.01375
-#> log_k2              -4.06264  -4.21344  -3.91184
-#> g_qlogis            -0.02174  -0.45898   0.41549
-#> a.1                  0.87598   0.67275   1.07922
-#> b.1                  0.07949   0.06389   0.09509
-#> SD.parent_0          0.19170 -30.36286  30.74626
-#> SD.log_k_m1          0.01883  -0.28736   0.32502
-#> SD.f_parent_qlogis   0.44300   0.16391   0.72209
-#> SD.log_k1            0.35320   0.09661   0.60978
-#> SD.log_k2            0.13707   0.02359   0.25056
-#> SD.g_qlogis          0.37478   0.04490   0.70467
-illparms(f_saem_dfop_sfo)
-#> [1] "sd(parent_0)" "sd(log_k_m1)"
-f_saem_dfop_sfo_2 <- update(f_saem_dfop_sfo,
-  no_random_effect = c("parent_0", "log_k_m1"))
-illparms(f_saem_dfop_sfo_2)
-intervals(f_saem_dfop_sfo_2)
-#> Approximate 95% confidence intervals
-#> 
-#>  Fixed effects:
-#>                      lower         est.        upper
-#> parent_0       98.36731429 101.42508066 104.48284703
-#> k_m1            0.01513234   0.01670094   0.01843214
-#> f_parent_to_m1  0.20221431   0.27608850   0.36461630
-#> k1              0.06915073   0.09759718   0.13774560
-#> k2              0.01487068   0.01740389   0.02036863
-#> g               0.37365671   0.48384821   0.59563299
-#> 
-#>  Random effects:
-#>                          lower      est.     upper
-#> sd(f_parent_qlogis) 0.16439770 0.4427585 0.7211193
-#> sd(log_k1)          0.08304243 0.3345213 0.5860002
-#> sd(log_k2)          0.03146410 0.1490210 0.2665779
-#> sd(g_qlogis)        0.06216385 0.4023430 0.7425221
-#> 
-#>  
-#>          lower       est.      upper
-#> a.1 0.67696663 0.87777355 1.07858048
-#> b.1 0.06363957 0.07878001 0.09392044
-summary(f_saem_dfop_sfo_2, data = TRUE)
-#> saemix version used for fitting:      3.2 
-#> mkin version used for pre-fitting:  1.2.3 
-#> R version used for fitting:         4.2.3 
-#> Date of fit:     Sun Apr 16 08:34:58 2023 
-#> Date of summary: Sun Apr 16 08:34:58 2023 
-#> 
-#> Equations:
-#> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
-#>            time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
-#>            * parent
-#> d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)
-#>            * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *
-#>            exp(-k2 * time))) * parent - k_m1 * m1
-#> 
-#> Data:
-#> 171 observations of 2 variable(s) grouped in 5 datasets
-#> 
-#> Model predictions using solution type analytical 
-#> 
-#> Fitted in 9.384 s
-#> Using 300, 100 iterations and 10 chains
-#> 
-#> Variance model: Two-component variance function 
-#> 
-#> Starting values for degradation parameters:
-#>        parent_0        log_k_m1 f_parent_qlogis          log_k1          log_k2 
-#>       101.65645        -4.05368        -0.94311        -2.35943        -4.07006 
-#>        g_qlogis 
-#>        -0.01132 
-#> 
-#> Fixed degradation parameter values:
-#> None
-#> 
-#> Starting values for random effects (square root of initial entries in omega):
-#>                 parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 g_qlogis
-#> parent_0           6.742   0.0000          0.0000 0.0000 0.0000    0.000
-#> log_k_m1           0.000   0.2236          0.0000 0.0000 0.0000    0.000
-#> f_parent_qlogis    0.000   0.0000          0.5572 0.0000 0.0000    0.000
-#> log_k1             0.000   0.0000          0.0000 0.8031 0.0000    0.000
-#> log_k2             0.000   0.0000          0.0000 0.0000 0.2931    0.000
-#> g_qlogis           0.000   0.0000          0.0000 0.0000 0.0000    0.807
-#> 
-#> Starting values for error model parameters:
-#> a.1 b.1 
-#>   1   1 
-#> 
-#> Results:
-#> 
-#> Likelihood computed by importance sampling
-#>   AIC   BIC logLik
-#>   807 802.3 -391.5
-#> 
-#> Optimised parameters:
-#>                         est.    lower     upper
-#> parent_0           101.42508 98.36731 104.48285
-#> log_k_m1            -4.09229 -4.19092  -3.99366
-#> f_parent_qlogis     -0.96395 -1.37251  -0.55538
-#> log_k1              -2.32691 -2.67147  -1.98235
-#> log_k2              -4.05106 -4.20836  -3.89376
-#> g_qlogis            -0.06463 -0.51656   0.38730
-#> a.1                  0.87777  0.67697   1.07858
-#> b.1                  0.07878  0.06364   0.09392
-#> SD.f_parent_qlogis   0.44276  0.16440   0.72112
-#> SD.log_k1            0.33452  0.08304   0.58600
-#> SD.log_k2            0.14902  0.03146   0.26658
-#> SD.g_qlogis          0.40234  0.06216   0.74252
-#> 
-#> Correlation: 
-#>                 parnt_0 lg_k_m1 f_prnt_ log_k1  log_k2 
-#> log_k_m1        -0.4693                                
-#> f_parent_qlogis -0.2378  0.2595                        
-#> log_k1           0.1720 -0.1593 -0.0669                
-#> log_k2           0.0179  0.0594  0.0035  0.1995        
-#> g_qlogis         0.1073 -0.1060 -0.0322 -0.2299 -0.3168
-#> 
-#> Random effects:
-#>                      est.   lower  upper
-#> SD.f_parent_qlogis 0.4428 0.16440 0.7211
-#> SD.log_k1          0.3345 0.08304 0.5860
-#> SD.log_k2          0.1490 0.03146 0.2666
-#> SD.g_qlogis        0.4023 0.06216 0.7425
-#> 
-#> Variance model:
-#>        est.   lower   upper
-#> a.1 0.87777 0.67697 1.07858
-#> b.1 0.07878 0.06364 0.09392
-#> 
-#> Backtransformed parameters:
-#>                    est.    lower     upper
-#> parent_0       101.4251 98.36731 104.48285
-#> k_m1             0.0167  0.01513   0.01843
-#> f_parent_to_m1   0.2761  0.20221   0.36462
-#> k1               0.0976  0.06915   0.13775
-#> k2               0.0174  0.01487   0.02037
-#> g                0.4838  0.37366   0.59563
-#> 
-#> Resulting formation fractions:
-#>                 ff
-#> parent_m1   0.2761
-#> parent_sink 0.7239
-#> 
-#> Estimated disappearance times:
-#>         DT50   DT90 DT50back DT50_k1 DT50_k2
-#> parent 15.54  94.33     28.4   7.102   39.83
-#> m1     41.50 137.87       NA      NA      NA
-#> 
-#> Data:
-#>    ds   name time observed predicted  residual    std standardized
-#>  ds 1 parent    0     89.8 1.014e+02 -11.62508 8.0383     -1.44620
-#>  ds 1 parent    0    104.1 1.014e+02   2.67492 8.0383      0.33277
-#>  ds 1 parent    1     88.7 9.650e+01  -7.80311 7.6530     -1.01961
-#>  ds 1 parent    1     95.5 9.650e+01  -1.00311 7.6530     -0.13107
-#>  ds 1 parent    3     81.8 8.753e+01  -5.72638 6.9510     -0.82382
-#>  ds 1 parent    3     94.5 8.753e+01   6.97362 6.9510      1.00326
-#>  ds 1 parent    7     71.5 7.254e+01  -1.04133 5.7818     -0.18010
-#>  ds 1 parent    7     70.3 7.254e+01  -2.24133 5.7818     -0.38765
-#>  ds 1 parent   14     54.2 5.349e+01   0.71029 4.3044      0.16502
-#>  ds 1 parent   14     49.6 5.349e+01  -3.88971 4.3044     -0.90366
-#>  ds 1 parent   28     31.5 3.167e+01  -0.16616 2.6446     -0.06283
-#>  ds 1 parent   28     28.8 3.167e+01  -2.86616 2.6446     -1.08379
-#>  ds 1 parent   60     12.1 1.279e+01  -0.69287 1.3365     -0.51843
-#>  ds 1 parent   60     13.6 1.279e+01   0.80713 1.3365      0.60392
-#>  ds 1 parent   90      6.2 6.397e+00  -0.19718 1.0122     -0.19481
-#>  ds 1 parent   90      8.3 6.397e+00   1.90282 1.0122      1.87996
-#>  ds 1 parent  120      2.2 3.323e+00  -1.12320 0.9160     -1.22623
-#>  ds 1 parent  120      2.4 3.323e+00  -0.92320 0.9160     -1.00788
-#>  ds 1     m1    1      0.3 1.179e+00  -0.87919 0.8827     -0.99605
-#>  ds 1     m1    1      0.2 1.179e+00  -0.97919 0.8827     -1.10935
-#>  ds 1     m1    3      2.2 3.273e+00  -1.07272 0.9149     -1.17256
-#>  ds 1     m1    3      3.0 3.273e+00  -0.27272 0.9149     -0.29811
-#>  ds 1     m1    7      6.5 6.559e+00  -0.05872 1.0186     -0.05765
-#>  ds 1     m1    7      5.0 6.559e+00  -1.55872 1.0186     -1.53032
-#>  ds 1     m1   14     10.2 1.016e+01   0.03787 1.1880      0.03188
-#>  ds 1     m1   14      9.5 1.016e+01  -0.66213 1.1880     -0.55734
-#>  ds 1     m1   28     12.2 1.268e+01  -0.47913 1.3297     -0.36032
-#>  ds 1     m1   28     13.4 1.268e+01   0.72087 1.3297      0.54211
-#>  ds 1     m1   60     11.8 1.078e+01   1.02493 1.2211      0.83936
-#>  ds 1     m1   60     13.2 1.078e+01   2.42493 1.2211      1.98588
-#>  ds 1     m1   90      6.6 7.705e+00  -1.10464 1.0672     -1.03509
-#>  ds 1     m1   90      9.3 7.705e+00   1.59536 1.0672      1.49491
-#>  ds 1     m1  120      3.5 5.236e+00  -1.73617 0.9699     -1.79010
-#>  ds 1     m1  120      5.4 5.236e+00   0.16383 0.9699      0.16892
-#>  ds 2 parent    0    118.0 1.014e+02  16.57492 8.0383      2.06198
-#>  ds 2 parent    0     99.8 1.014e+02  -1.62508 8.0383     -0.20217
-#>  ds 2 parent    1     90.2 9.599e+01  -5.79045 7.6129     -0.76061
-#>  ds 2 parent    1     94.6 9.599e+01  -1.39045 7.6129     -0.18264
-#>  ds 2 parent    3     96.1 8.652e+01   9.57931 6.8724      1.39388
-#>  ds 2 parent    3     78.4 8.652e+01  -8.12069 6.8724     -1.18164
-#>  ds 2 parent    7     77.9 7.197e+01   5.93429 5.7370      1.03439
-#>  ds 2 parent    7     77.7 7.197e+01   5.73429 5.7370      0.99953
-#>  ds 2 parent   14     56.0 5.555e+01   0.44657 4.4637      0.10005
-#>  ds 2 parent   14     54.7 5.555e+01  -0.85343 4.4637     -0.19120
-#>  ds 2 parent   28     36.6 3.853e+01  -1.93170 3.1599     -0.61132
-#>  ds 2 parent   28     36.8 3.853e+01  -1.73170 3.1599     -0.54803
-#>  ds 2 parent   60     22.1 2.110e+01   1.00360 1.8795      0.53396
-#>  ds 2 parent   60     24.7 2.110e+01   3.60360 1.8795      1.91728
-#>  ds 2 parent   90     12.4 1.250e+01  -0.09712 1.3190     -0.07363
-#>  ds 2 parent   90     10.8 1.250e+01  -1.69712 1.3190     -1.28667
-#>  ds 2 parent  120      6.8 7.419e+00  -0.61913 1.0546     -0.58709
-#>  ds 2 parent  120      7.9 7.419e+00   0.48087 1.0546      0.45599
-#>  ds 2     m1    1      1.3 1.422e+00  -0.12194 0.8849     -0.13781
-#>  ds 2     m1    3      3.7 3.831e+00  -0.13149 0.9282     -0.14166
-#>  ds 2     m1    3      4.7 3.831e+00   0.86851 0.9282      0.93567
-#>  ds 2     m1    7      8.1 7.292e+00   0.80812 1.0490      0.77034
-#>  ds 2     m1    7      7.9 7.292e+00   0.60812 1.0490      0.57969
-#>  ds 2     m1   14     10.1 1.055e+01  -0.45332 1.2090     -0.37495
-#>  ds 2     m1   14     10.3 1.055e+01  -0.25332 1.2090     -0.20953
-#>  ds 2     m1   28     10.7 1.230e+01  -1.59960 1.3074     -1.22347
-#>  ds 2     m1   28     12.2 1.230e+01  -0.09960 1.3074     -0.07618
-#>  ds 2     m1   60     10.7 1.065e+01   0.05342 1.2141      0.04400
-#>  ds 2     m1   60     12.5 1.065e+01   1.85342 1.2141      1.52661
-#>  ds 2     m1   90      9.1 8.196e+00   0.90368 1.0897      0.82930
-#>  ds 2     m1   90      7.4 8.196e+00  -0.79632 1.0897     -0.73078
-#>  ds 2     m1  120      6.1 5.997e+00   0.10252 0.9969      0.10284
-#>  ds 2     m1  120      4.5 5.997e+00  -1.49748 0.9969     -1.50220
-#>  ds 3 parent    0    106.2 1.014e+02   4.77492 8.0383      0.59402
-#>  ds 3 parent    0    106.9 1.014e+02   5.47492 8.0383      0.68110
-#>  ds 3 parent    1    107.4 9.390e+01  13.49935 7.4494      1.81214
-#>  ds 3 parent    1     96.1 9.390e+01   2.19935 7.4494      0.29524
-#>  ds 3 parent    3     79.4 8.152e+01  -2.12307 6.4821     -0.32753
-#>  ds 3 parent    3     82.6 8.152e+01   1.07693 6.4821      0.16614
-#>  ds 3 parent    7     63.9 6.446e+01  -0.55834 5.1533     -0.10834
-#>  ds 3 parent    7     62.4 6.446e+01  -2.05834 5.1533     -0.39942
-#>  ds 3 parent   14     51.0 4.826e+01   2.74073 3.9019      0.70241
-#>  ds 3 parent   14     47.1 4.826e+01  -1.15927 3.9019     -0.29711
-#>  ds 3 parent   28     36.1 3.424e+01   1.86399 2.8364      0.65718
-#>  ds 3 parent   28     36.6 3.424e+01   2.36399 2.8364      0.83346
-#>  ds 3 parent   60     20.1 1.968e+01   0.42172 1.7815      0.23672
-#>  ds 3 parent   60     19.8 1.968e+01   0.12172 1.7815      0.06833
-#>  ds 3 parent   90     11.3 1.195e+01  -0.64633 1.2869     -0.50222
-#>  ds 3 parent   90     10.7 1.195e+01  -1.24633 1.2869     -0.96844
-#>  ds 3 parent  120      8.2 7.255e+00   0.94532 1.0474      0.90251
-#>  ds 3 parent  120      7.3 7.255e+00   0.04532 1.0474      0.04327
-#>  ds 3     m1    0      0.8 2.956e-11   0.80000 0.8778      0.91140
-#>  ds 3     m1    1      1.8 1.758e+00   0.04187 0.8886      0.04712
-#>  ds 3     m1    1      2.3 1.758e+00   0.54187 0.8886      0.60978
-#>  ds 3     m1    3      4.2 4.567e+00  -0.36697 0.9486     -0.38683
-#>  ds 3     m1    3      4.1 4.567e+00  -0.46697 0.9486     -0.49224
-#>  ds 3     m1    7      6.8 8.151e+00  -1.35124 1.0876     -1.24242
-#>  ds 3     m1    7     10.1 8.151e+00   1.94876 1.0876      1.79182
-#>  ds 3     m1   14     11.4 1.083e+01   0.57098 1.2240      0.46647
-#>  ds 3     m1   14     12.8 1.083e+01   1.97098 1.2240      1.61022
-#>  ds 3     m1   28     11.5 1.147e+01   0.03175 1.2597      0.02520
-#>  ds 3     m1   28     10.6 1.147e+01  -0.86825 1.2597     -0.68928
-#>  ds 3     m1   60      7.5 9.298e+00  -1.79834 1.1433     -1.57298
-#>  ds 3     m1   60      8.6 9.298e+00  -0.69834 1.1433     -0.61083
-#>  ds 3     m1   90      7.3 7.038e+00   0.26249 1.0382      0.25283
-#>  ds 3     m1   90      8.1 7.038e+00   1.06249 1.0382      1.02340
-#>  ds 3     m1  120      5.3 5.116e+00   0.18417 0.9659      0.19068
-#>  ds 3     m1  120      3.8 5.116e+00  -1.31583 0.9659     -1.36232
-#>  ds 4 parent    0    104.7 1.014e+02   3.27492 8.0383      0.40741
-#>  ds 4 parent    0     88.3 1.014e+02 -13.12508 8.0383     -1.63281
-#>  ds 4 parent    1     94.2 9.781e+01  -3.61183 7.7555     -0.46572
-#>  ds 4 parent    1     94.6 9.781e+01  -3.21183 7.7555     -0.41414
-#>  ds 4 parent    3     78.1 9.110e+01 -13.00467 7.2307     -1.79853
-#>  ds 4 parent    3     96.5 9.110e+01   5.39533 7.2307      0.74617
-#>  ds 4 parent    7     76.2 7.951e+01  -3.30511 6.3246     -0.52258
-#>  ds 4 parent    7     77.8 7.951e+01  -1.70511 6.3246     -0.26960
-#>  ds 4 parent   14     70.8 6.376e+01   7.03783 5.0993      1.38016
-#>  ds 4 parent   14     67.3 6.376e+01   3.53783 5.0993      0.69379
-#>  ds 4 parent   28     43.1 4.340e+01  -0.30456 3.5303     -0.08627
-#>  ds 4 parent   28     45.1 4.340e+01   1.69544 3.5303      0.48026
-#>  ds 4 parent   60     21.3 2.142e+01  -0.12077 1.9022     -0.06349
-#>  ds 4 parent   60     23.5 2.142e+01   2.07923 1.9022      1.09308
-#>  ds 4 parent   90     11.8 1.207e+01  -0.26813 1.2940     -0.20721
-#>  ds 4 parent   90     12.1 1.207e+01   0.03187 1.2940      0.02463
-#>  ds 4 parent  120      7.0 6.954e+00   0.04554 1.0347      0.04402
-#>  ds 4 parent  120      6.2 6.954e+00  -0.75446 1.0347     -0.72914
-#>  ds 4     m1    0      1.6 1.990e-13   1.60000 0.8778      1.82279
-#>  ds 4     m1    1      0.9 7.305e-01   0.16949 0.8797      0.19267
-#>  ds 4     m1    3      3.7 2.051e+00   1.64896 0.8925      1.84753
-#>  ds 4     m1    3      2.0 2.051e+00  -0.05104 0.8925     -0.05719
-#>  ds 4     m1    7      3.6 4.204e+00  -0.60375 0.9382     -0.64354
-#>  ds 4     m1    7      3.8 4.204e+00  -0.40375 0.9382     -0.43036
-#>  ds 4     m1   14      7.1 6.760e+00   0.34021 1.0267      0.33137
-#>  ds 4     m1   14      6.6 6.760e+00  -0.15979 1.0267     -0.15563
-#>  ds 4     m1   28      9.5 9.011e+00   0.48856 1.1289      0.43277
-#>  ds 4     m1   28      9.3 9.011e+00   0.28856 1.1289      0.25561
-#>  ds 4     m1   60      8.3 8.611e+00  -0.31077 1.1093     -0.28014
-#>  ds 4     m1   60      9.0 8.611e+00   0.38923 1.1093      0.35086
-#>  ds 4     m1   90      6.6 6.678e+00  -0.07753 1.0233     -0.07576
-#>  ds 4     m1   90      7.7 6.678e+00   1.02247 1.0233      0.99915
-#>  ds 4     m1  120      3.7 4.847e+00  -1.14679 0.9572     -1.19804
-#>  ds 4     m1  120      3.5 4.847e+00  -1.34679 0.9572     -1.40698
-#>  ds 5 parent    0    110.4 1.014e+02   8.97492 8.0383      1.11651
-#>  ds 5 parent    0    112.1 1.014e+02  10.67492 8.0383      1.32800
-#>  ds 5 parent    1     93.5 9.466e+01  -1.16118 7.5089     -0.15464
-#>  ds 5 parent    1     91.0 9.466e+01  -3.66118 7.5089     -0.48758
-#>  ds 5 parent    3     71.0 8.302e+01 -12.01844 6.5988     -1.82130
-#>  ds 5 parent    3     89.7 8.302e+01   6.68156 6.5988      1.01254
-#>  ds 5 parent    7     60.4 6.563e+01  -5.22574 5.2440     -0.99652
-#>  ds 5 parent    7     59.1 6.563e+01  -6.52574 5.2440     -1.24442
-#>  ds 5 parent   14     56.5 4.727e+01   9.22621 3.8263      2.41128
-#>  ds 5 parent   14     47.0 4.727e+01  -0.27379 3.8263     -0.07156
-#>  ds 5 parent   28     30.2 3.103e+01  -0.83405 2.5977     -0.32108
-#>  ds 5 parent   28     23.9 3.103e+01  -7.13405 2.5977     -2.74634
-#>  ds 5 parent   60     17.0 1.800e+01  -0.99696 1.6675     -0.59787
-#>  ds 5 parent   60     18.7 1.800e+01   0.70304 1.6675      0.42161
-#>  ds 5 parent   90     11.3 1.167e+01  -0.36809 1.2710     -0.28961
-#>  ds 5 parent   90     11.9 1.167e+01   0.23191 1.2710      0.18246
-#>  ds 5 parent  120      9.0 7.595e+00   1.40496 1.0623      1.32256
-#>  ds 5 parent  120      8.1 7.595e+00   0.50496 1.0623      0.47535
-#>  ds 5     m1    0      0.7 0.000e+00   0.70000 0.8778      0.79747
-#>  ds 5     m1    1      3.0 3.158e+00  -0.15799 0.9123     -0.17317
-#>  ds 5     m1    1      2.6 3.158e+00  -0.55799 0.9123     -0.61160
-#>  ds 5     m1    3      5.1 8.443e+00  -3.34286 1.1013     -3.03535
-#>  ds 5     m1    3      7.5 8.443e+00  -0.94286 1.1013     -0.85613
-#>  ds 5     m1    7     16.5 1.580e+01   0.69781 1.5232      0.45811
-#>  ds 5     m1    7     19.0 1.580e+01   3.19781 1.5232      2.09935
-#>  ds 5     m1   14     22.9 2.216e+01   0.73604 1.9543      0.37663
-#>  ds 5     m1   14     23.2 2.216e+01   1.03604 1.9543      0.53014
-#>  ds 5     m1   28     22.2 2.423e+01  -2.03128 2.1011     -0.96678
-#>  ds 5     m1   28     24.4 2.423e+01   0.16872 2.1011      0.08030
-#>  ds 5     m1   60     15.5 1.876e+01  -3.25610 1.7187     -1.89455
-#>  ds 5     m1   60     19.8 1.876e+01   1.04390 1.7187      0.60739
-#>  ds 5     m1   90     14.9 1.366e+01   1.23585 1.3890      0.88976
-#>  ds 5     m1   90     14.2 1.366e+01   0.53585 1.3890      0.38579
-#>  ds 5     m1  120     10.9 9.761e+00   1.13911 1.1670      0.97613
-#>  ds 5     m1  120     10.4 9.761e+00   0.63911 1.1670      0.54767
-# Add a correlation between random effects of g and k2
-cov_model_3 <- f_saem_dfop_sfo_2$so@model@covariance.model
-cov_model_3["log_k2", "g_qlogis"] <- 1
-cov_model_3["g_qlogis", "log_k2"] <- 1
-f_saem_dfop_sfo_3 <- update(f_saem_dfop_sfo,
-  covariance.model = cov_model_3)
-intervals(f_saem_dfop_sfo_3)
-#> Approximate 95% confidence intervals
-#> 
-#>  Fixed effects:
-#>                      lower         est.        upper
-#> parent_0       98.39888363 101.48951337 104.58014311
-#> k_m1            0.01508704   0.01665986   0.01839665
-#> f_parent_to_m1  0.20141557   0.27540583   0.36418131
-#> k1              0.07708759   0.10430866   0.14114200
-#> k2              0.01476621   0.01786384   0.02161129
-#> g               0.33679867   0.45083525   0.57028162
-#> 
-#>  Random effects:
-#>                             lower       est.      upper
-#> sd(f_parent_qlogis)    0.38085375  0.4441841  0.5075145
-#> sd(log_k1)             0.04774819  0.2660384  0.4843286
-#> sd(log_k2)            -0.63842736  0.1977024  1.0338321
-#> sd(g_qlogis)           0.22711289  0.4502227  0.6733326
-#> corr(log_k2,g_qlogis) -0.83271473 -0.6176939 -0.4026730
-#> 
-#>  
-#>          lower       est.      upper
-#> a.1 0.67347568 0.87437392 1.07527216
-#> b.1 0.06393032 0.07912417 0.09431802
-# The correlation does not improve the fit judged by AIC and BIC, although
-# the likelihood is higher with the additional parameter
-anova(f_saem_dfop_sfo, f_saem_dfop_sfo_2, f_saem_dfop_sfo_3)
-#> Data: 171 observations of 2 variable(s) grouped in 5 datasets
-#> 
-#>                   npar    AIC    BIC     Lik
-#> f_saem_dfop_sfo_2   12 806.96 802.27 -391.48
-#> f_saem_dfop_sfo_3   13 807.99 802.91 -391.00
-#> f_saem_dfop_sfo     14 810.83 805.36 -391.42
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/summary_listing.html b/docs/dev/reference/summary_listing.html deleted file mode 100644 index e584416a..00000000 --- a/docs/dev/reference/summary_listing.html +++ /dev/null @@ -1,164 +0,0 @@ - -Display the output of a summary function according to the output format — summary_listing • mkin - - -
-
- - - -
-
-
-

Display the output of a summary function according to the output format

- Source: R/summary_listing.R - -
- -
-

This function is intended for use in a R markdown code chunk with the chunk -option results = "asis".

-
- -
- 
summary_listing(object, caption = NULL, label = NULL, clearpage = TRUE)
-
-tex_listing(object, caption = NULL, label = NULL, clearpage = TRUE)
-
-html_listing(object, caption = NULL)
-
- -
-

Arguments

-
object
-

The object for which the summary is to be listed

- - -
caption
-

An optional caption

- - -
label
-

An optional label, ignored in html output

- - -
clearpage
-

Should a new page be started after the listing? Ignored in html output

- -
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/synthetic_data_for_UBA_2014-1.png b/docs/dev/reference/synthetic_data_for_UBA_2014-1.png deleted file mode 100644 index 11eae1f9..00000000 Binary files a/docs/dev/reference/synthetic_data_for_UBA_2014-1.png and /dev/null differ diff --git a/docs/dev/reference/synthetic_data_for_UBA_2014.html b/docs/dev/reference/synthetic_data_for_UBA_2014.html deleted file mode 100644 index b8154c47..00000000 --- a/docs/dev/reference/synthetic_data_for_UBA_2014.html +++ /dev/null @@ -1,446 +0,0 @@ - -Synthetic datasets for one parent compound with two metabolites — synthetic_data_for_UBA_2014 • mkin - - -
-
- - - -
-
-
-

Synthetic datasets for one parent compound with two metabolites

- - -
- -
-

The 12 datasets were generated using four different models and three different - variance components. The four models are either the SFO or the DFOP model with either - two sequential or two parallel metabolites.

-

Variance component 'a' is based on a normal distribution with standard deviation of 3, - Variance component 'b' is also based on a normal distribution, but with a standard deviation of 7. - Variance component 'c' is based on the error model from Rocke and Lorenzato (1995), with the - minimum standard deviation (for small y values) of 0.5, and a proportionality constant of 0.07 - for the increase of the standard deviation with y. Note that this is a simplified version - of the error model proposed by Rocke and Lorenzato (1995), as in their model the error of the - measured values approximates lognormal distribution for high values, whereas we are using - normally distributed error components all along.

-

Initial concentrations for metabolites and all values where adding the variance component resulted - in a value below the assumed limit of detection of 0.1 were set to NA.

-

As an example, the first dataset has the title SFO_lin_a and is based on the SFO model - with two sequential metabolites (linear pathway), with added variance component 'a'.

-

Compare also the code in the example section to see the degradation models.

-
- -
- 
synthetic_data_for_UBA_2014
-
- -
-

Format

-

A list containing twelve datasets as an R6 class defined by mkinds, - each containing, among others, the following components

title
-

The name of the dataset, e.g. SFO_lin_a

- -
data
-

A data frame with the data in the form expected by mkinfit

- - -
-
-

Source

-

Ranke (2014) Prüfung und Validierung von Modellierungssoftware als Alternative - zu ModelMaker 4.0, Umweltbundesamt Projektnummer 27452

-

Rocke, David M. und Lorenzato, Stefan (1995) A two-component model for - measurement error in analytical chemistry. Technometrics 37(2), 176-184.

-
- -
-

Examples

- 
# \dontrun{
-# The data have been generated using the following kinetic models
-m_synth_SFO_lin <- mkinmod(parent = list(type = "SFO", to = "M1"),
-                           M1 = list(type = "SFO", to = "M2"),
-                           M2 = list(type = "SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-
-m_synth_SFO_par <- mkinmod(parent = list(type = "SFO", to = c("M1", "M2"),
-                                         sink = FALSE),
-                           M1 = list(type = "SFO"),
-                           M2 = list(type = "SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-m_synth_DFOP_lin <- mkinmod(parent = list(type = "DFOP", to = "M1"),
-                            M1 = list(type = "SFO", to = "M2"),
-                            M2 = list(type = "SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-m_synth_DFOP_par <- mkinmod(parent = list(type = "DFOP", to = c("M1", "M2"),
-                                          sink = FALSE),
-                            M1 = list(type = "SFO"),
-                            M2 = list(type = "SFO"), use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-# The model predictions without intentional error were generated as follows
-sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-
-d_synth_SFO_lin <- mkinpredict(m_synth_SFO_lin,
-                               c(k_parent = 0.7, f_parent_to_M1 = 0.8,
-                                 k_M1 = 0.3, f_M1_to_M2 = 0.7,
-                                 k_M2 = 0.02),
-                               c(parent = 100, M1 = 0, M2 = 0),
-                               sampling_times)
-
-d_synth_DFOP_lin <- mkinpredict(m_synth_DFOP_lin,
-                                c(k1 = 0.2, k2 = 0.02, g = 0.5,
-                                  f_parent_to_M1 = 0.5, k_M1 = 0.3,
-                                  f_M1_to_M2 = 0.7, k_M2 = 0.02),
-                                 c(parent = 100, M1 = 0, M2 = 0),
-                                 sampling_times)
-
-d_synth_SFO_par <- mkinpredict(m_synth_SFO_par,
-                               c(k_parent = 0.2,
-                                 f_parent_to_M1 = 0.8, k_M1 = 0.01,
-                                 f_parent_to_M2 = 0.2, k_M2 = 0.02),
-                                 c(parent = 100, M1 = 0, M2 = 0),
-                                 sampling_times)
-
-d_synth_DFOP_par <- mkinpredict(m_synth_DFOP_par,
-                               c(k1 = 0.3, k2 = 0.02, g = 0.7,
-                                 f_parent_to_M1 = 0.6, k_M1 = 0.04,
-                                 f_parent_to_M2 = 0.4, k_M2 = 0.01),
-                                 c(parent = 100, M1 = 0, M2 = 0),
-                                 sampling_times)
-
-# Construct names for datasets with errors
-d_synth_names = paste0("d_synth_", c("SFO_lin", "SFO_par",
-                                     "DFOP_lin", "DFOP_par"))
-
-# Original function used or adding errors. The add_err function now published
-# with this package is a slightly generalised version where the names of
-# secondary compartments that should have an initial value of zero (M1 and M2
-# in this case) are not hardcoded any more.
-# add_err = function(d, sdfunc, LOD = 0.1, reps = 2, seed = 123456789)
-# {
-#   set.seed(seed)
-#   d_long = mkin_wide_to_long(d, time = "time")
-#   d_rep = data.frame(lapply(d_long, rep, each = 2))
-#   d_rep$value = rnorm(length(d_rep$value), d_rep$value, sdfunc(d_rep$value))
-#
-#   d_rep[d_rep$time == 0 & d_rep$name %in% c("M1", "M2"), "value"] <- 0
-#   d_NA <- transform(d_rep, value = ifelse(value < LOD, NA, value))
-#   d_NA$value <- round(d_NA$value, 1)
-#   return(d_NA)
-# }
-
-# The following is the simplified version of the two-component model of Rocke
-# and Lorenzato (1995)
-sdfunc_twocomp = function(value, sd_low, rsd_high) {
-  sqrt(sd_low^2 + value^2 * rsd_high^2)
-}
-
-# Add the errors.
-for (d_synth_name in d_synth_names)
-{
-  d_synth = get(d_synth_name)
-  assign(paste0(d_synth_name, "_a"), add_err(d_synth, function(value) 3))
-  assign(paste0(d_synth_name, "_b"), add_err(d_synth, function(value) 7))
-  assign(paste0(d_synth_name, "_c"), add_err(d_synth,
-                           function(value) sdfunc_twocomp(value, 0.5, 0.07)))
-
-}
-
-d_synth_err_names = c(
-  paste(rep(d_synth_names, each = 3), letters[1:3], sep = "_")
-)
-
-# This is just one example of an evaluation using the kinetic model used for
-# the generation of the data
-  fit <- mkinfit(m_synth_SFO_lin, synthetic_data_for_UBA_2014[[1]]$data,
-                 quiet = TRUE)
-  plot_sep(fit)
-
-  summary(fit)
-#> mkin version used for fitting:    1.2.3 
-#> R version used for fitting:       4.2.3 
-#> Date of fit:     Sun Apr 16 08:35:08 2023 
-#> Date of summary: Sun Apr 16 08:35:08 2023 
-#> 
-#> Equations:
-#> d_parent/dt = - k_parent * parent
-#> d_M1/dt = + f_parent_to_M1 * k_parent * parent - k_M1 * M1
-#> d_M2/dt = + f_M1_to_M2 * k_M1 * M1 - k_M2 * M2
-#> 
-#> Model predictions using solution type deSolve 
-#> 
-#> Fitted using 833 model solutions performed in 0.166 s
-#> 
-#> Error model: Constant variance 
-#> 
-#> Error model algorithm: OLS 
-#> 
-#> Starting values for parameters to be optimised:
-#>                   value   type
-#> parent_0       101.3500  state
-#> k_parent         0.1000 deparm
-#> k_M1             0.1001 deparm
-#> k_M2             0.1002 deparm
-#> f_parent_to_M1   0.5000 deparm
-#> f_M1_to_M2       0.5000 deparm
-#> 
-#> Starting values for the transformed parameters actually optimised:
-#>                      value lower upper
-#> parent_0        101.350000  -Inf   Inf
-#> log_k_parent     -2.302585  -Inf   Inf
-#> log_k_M1         -2.301586  -Inf   Inf
-#> log_k_M2         -2.300587  -Inf   Inf
-#> f_parent_qlogis   0.000000  -Inf   Inf
-#> f_M1_qlogis       0.000000  -Inf   Inf
-#> 
-#> Fixed parameter values:
-#>      value  type
-#> M1_0     0 state
-#> M2_0     0 state
-#> 
-#> Results:
-#> 
-#>        AIC      BIC    logLik
-#>   188.7274 200.3723 -87.36368
-#> 
-#> Optimised, transformed parameters with symmetric confidence intervals:
-#>                 Estimate Std. Error   Lower    Upper
-#> parent_0        102.1000    1.57000 98.8600 105.3000
-#> log_k_parent     -0.3020    0.03885 -0.3812  -0.2229
-#> log_k_M1         -1.2070    0.07123 -1.3520  -1.0620
-#> log_k_M2         -3.9010    0.06571 -4.0350  -3.7670
-#> f_parent_qlogis   1.2010    0.23530  0.7216   1.6800
-#> f_M1_qlogis       0.9589    0.24890  0.4520   1.4660
-#> sigma             2.2730    0.25740  1.7490   2.7970
-#> 
-#> Parameter correlation:
-#>                   parent_0 log_k_parent   log_k_M1   log_k_M2 f_parent_qlogis
-#> parent_0         1.000e+00    3.933e-01 -1.605e-01  2.819e-02      -4.624e-01
-#> log_k_parent     3.933e-01    1.000e+00 -4.082e-01  7.166e-02      -5.682e-01
-#> log_k_M1        -1.605e-01   -4.082e-01  1.000e+00 -3.929e-01       7.478e-01
-#> log_k_M2         2.819e-02    7.166e-02 -3.929e-01  1.000e+00      -2.658e-01
-#> f_parent_qlogis -4.624e-01   -5.682e-01  7.478e-01 -2.658e-01       1.000e+00
-#> f_M1_qlogis      1.614e-01    4.102e-01 -8.109e-01  5.419e-01      -8.605e-01
-#> sigma           -2.900e-08   -8.030e-09 -2.741e-08  3.938e-08      -2.681e-08
-#>                 f_M1_qlogis      sigma
-#> parent_0          1.614e-01 -2.900e-08
-#> log_k_parent      4.102e-01 -8.030e-09
-#> log_k_M1         -8.109e-01 -2.741e-08
-#> log_k_M2          5.419e-01  3.938e-08
-#> f_parent_qlogis  -8.605e-01 -2.681e-08
-#> f_M1_qlogis       1.000e+00  4.971e-08
-#> sigma             4.971e-08  1.000e+00
-#> 
-#> Backtransformed parameters:
-#> Confidence intervals for internally transformed parameters are asymmetric.
-#> t-test (unrealistically) based on the assumption of normal distribution
-#> for estimators of untransformed parameters.
-#>                 Estimate t value    Pr(>t)    Lower     Upper
-#> parent_0       102.10000  65.000 7.281e-36 98.86000 105.30000
-#> k_parent         0.73930  25.740 2.948e-23  0.68310   0.80020
-#> k_M1             0.29920  14.040 1.577e-15  0.25880   0.34590
-#> k_M2             0.02023  15.220 1.653e-16  0.01769   0.02312
-#> f_parent_to_M1   0.76870  18.370 7.295e-19  0.67300   0.84290
-#> f_M1_to_M2       0.72290  14.500 6.418e-16  0.61110   0.81240
-#> sigma            2.27300   8.832 2.161e-10  1.74900   2.79700
-#> 
-#> FOCUS Chi2 error levels in percent:
-#>          err.min n.optim df
-#> All data   8.454       6 17
-#> parent     8.660       2  6
-#> M1        10.583       2  5
-#> M2         3.586       2  6
-#> 
-#> Resulting formation fractions:
-#>                 ff
-#> parent_M1   0.7687
-#> parent_sink 0.2313
-#> M1_M2       0.7229
-#> M1_sink     0.2771
-#> 
-#> Estimated disappearance times:
-#>           DT50    DT90
-#> parent  0.9376   3.114
-#> M1      2.3170   7.697
-#> M2     34.2689 113.839
-#> 
-#> Data:
-#>  time variable observed  predicted residual
-#>     0   parent    101.5  1.021e+02 -0.56248
-#>     0   parent    101.2  1.021e+02 -0.86248
-#>     1   parent     53.9  4.873e+01  5.17118
-#>     1   parent     47.5  4.873e+01 -1.22882
-#>     3   parent     10.4  1.111e+01 -0.70773
-#>     3   parent      7.6  1.111e+01 -3.50773
-#>     7   parent      1.1  5.772e-01  0.52283
-#>     7   parent      0.3  5.772e-01 -0.27717
-#>    14   parent      3.5  3.264e-03  3.49674
-#>    28   parent      3.2  1.045e-07  3.20000
-#>    90   parent      0.6  9.530e-10  0.60000
-#>   120   parent      3.5 -5.940e-10  3.50000
-#>     1       M1     36.4  3.479e+01  1.61088
-#>     1       M1     37.4  3.479e+01  2.61088
-#>     3       M1     34.3  3.937e+01 -5.07027
-#>     3       M1     39.8  3.937e+01  0.42973
-#>     7       M1     15.1  1.549e+01 -0.38715
-#>     7       M1     17.8  1.549e+01  2.31285
-#>    14       M1      5.8  1.995e+00  3.80469
-#>    14       M1      1.2  1.995e+00 -0.79531
-#>    60       M1      0.5  2.111e-06  0.50000
-#>    90       M1      3.2 -9.670e-10  3.20000
-#>   120       M1      1.5  7.670e-10  1.50000
-#>   120       M1      0.6  7.670e-10  0.60000
-#>     1       M2      4.8  4.455e+00  0.34517
-#>     3       M2     20.9  2.153e+01 -0.62527
-#>     3       M2     19.3  2.153e+01 -2.22527
-#>     7       M2     42.0  4.192e+01  0.07941
-#>     7       M2     43.1  4.192e+01  1.17941
-#>    14       M2     49.4  4.557e+01  3.83353
-#>    14       M2     44.3  4.557e+01 -1.26647
-#>    28       M2     34.6  3.547e+01 -0.87275
-#>    28       M2     33.0  3.547e+01 -2.47275
-#>    60       M2     18.8  1.858e+01  0.21837
-#>    60       M2     17.6  1.858e+01 -0.98163
-#>    90       M2     10.6  1.013e+01  0.47130
-#>    90       M2     10.8  1.013e+01  0.67130
-#>   120       M2      9.8  5.521e+00  4.27893
-#>   120       M2      3.3  5.521e+00 -2.22107
-# }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/test_data_from_UBA_2014-1.png b/docs/dev/reference/test_data_from_UBA_2014-1.png deleted file mode 100644 index a007a102..00000000 Binary files a/docs/dev/reference/test_data_from_UBA_2014-1.png and /dev/null differ diff --git a/docs/dev/reference/test_data_from_UBA_2014-2.png b/docs/dev/reference/test_data_from_UBA_2014-2.png deleted file mode 100644 index f460ac83..00000000 Binary files a/docs/dev/reference/test_data_from_UBA_2014-2.png and /dev/null differ diff --git a/docs/dev/reference/test_data_from_UBA_2014.html b/docs/dev/reference/test_data_from_UBA_2014.html deleted file mode 100644 index 8b0194f6..00000000 --- a/docs/dev/reference/test_data_from_UBA_2014.html +++ /dev/null @@ -1,236 +0,0 @@ - -Three experimental datasets from two water sediment systems and one soil — test_data_from_UBA_2014 • mkin - - -
-
- - - -
-
-
-

Three experimental datasets from two water sediment systems and one soil

- - -
- -
-

The datasets were used for the comparative validation of several kinetic evaluation - software packages (Ranke, 2014).

-
- -
- 
test_data_from_UBA_2014
-
- -
-

Format

-

A list containing three datasets as an R6 class defined by mkinds. - Each dataset has, among others, the following components

title
-

The name of the dataset, e.g. UBA_2014_WS_river

- -
data
-

A data frame with the data in the form expected by mkinfit

- - -
-
-

Source

-

Ranke (2014) Prüfung und Validierung von Modellierungssoftware als Alternative - zu ModelMaker 4.0, Umweltbundesamt Projektnummer 27452

-
- -
-

Examples

- 
  # \dontrun{
-  # This is a level P-II evaluation of the dataset according to the FOCUS kinetics
-  # guidance. Due to the strong correlation of the parameter estimates, the
-  # covariance matrix is not returned. Note that level P-II evaluations are
-  # generally considered deprecated due to the frequent occurrence of such
-  # large parameter correlations, among other reasons (e.g. the adequacy of the
-  # model).
-  m_ws <- mkinmod(parent_w = mkinsub("SFO", "parent_s"),
-                  parent_s = mkinsub("SFO", "parent_w"))
-#> Temporary DLL for differentials generated and loaded
-  f_river <- mkinfit(m_ws, test_data_from_UBA_2014[[1]]$data, quiet = TRUE)
-#> Warning: Observations with value of zero were removed from the data
-  plot_sep(f_river)
-
-
-  summary(f_river)$bpar
-#> Warning: Could not calculate correlation; no covariance matrix
-#>                           Estimate se_notrans t value Pr(>t) Lower Upper
-#> parent_w_0             95.91998118         NA      NA     NA    NA    NA
-#> k_parent_w              0.41145375         NA      NA     NA    NA    NA
-#> k_parent_s              0.04663944         NA      NA     NA    NA    NA
-#> f_parent_w_to_parent_s  0.12467894         NA      NA     NA    NA    NA
-#> f_parent_s_to_parent_w  0.50000000         NA      NA     NA    NA    NA
-#> sigma                   3.13612618         NA      NA     NA    NA    NA
-  mkinerrmin(f_river)
-#>            err.min n.optim df
-#> All data 0.1090929       5  6
-#> parent_w 0.0817436       3  3
-#> parent_s 0.1619965       2  3
-
-  # This is the evaluation used for the validation of software packages
-  # in the expertise from 2014
-  m_soil <- mkinmod(parent = mkinsub("SFO", c("M1", "M2")),
-                    M1 = mkinsub("SFO", "M3"),
-                    M2 = mkinsub("SFO", "M3"),
-                    M3 = mkinsub("SFO"),
-                    use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-  f_soil <- mkinfit(m_soil, test_data_from_UBA_2014[[3]]$data, quiet = TRUE)
-#> Warning: Observations with value of zero were removed from the data
-  plot_sep(f_soil, lpos = c("topright", "topright", "topright", "bottomright"))
-
-  summary(f_soil)$bpar
-#>                   Estimate  se_notrans    t value       Pr(>t)        Lower
-#> parent_0       76.55425650 0.859186399 89.1008710 1.113861e-26 74.755959418
-#> k_parent        0.12081956 0.004601918 26.2541722 1.077359e-16  0.111561575
-#> k_M1            0.84258615 0.806160102  1.0451846 1.545268e-01  0.113779609
-#> k_M2            0.04210880 0.017083034  2.4649483 1.170188e-02  0.018013857
-#> k_M3            0.01122918 0.007245856  1.5497385 6.885052e-02  0.002909431
-#> f_parent_to_M1  0.32240200 0.240783943  1.3389680 9.819076e-02           NA
-#> f_parent_to_M2  0.16099855 0.033691952  4.7785464 6.531136e-05           NA
-#> f_M1_to_M3      0.27921507 0.269423780  1.0363416 1.565267e-01  0.022978205
-#> f_M2_to_M3      0.55641252 0.595119966  0.9349586 1.807707e-01  0.008002509
-#> sigma           1.14005399 0.149696423  7.6157731 1.727024e-07  0.826735778
-#>                      Upper
-#> parent_0       78.35255358
-#> k_parent        0.13084582
-#> k_M1            6.23970702
-#> k_M2            0.09843260
-#> k_M3            0.04333992
-#> f_parent_to_M1          NA
-#> f_parent_to_M2          NA
-#> f_M1_to_M3      0.86450775
-#> f_M2_to_M3      0.99489895
-#> sigma           1.45337221
-  mkinerrmin(f_soil)
-#>             err.min n.optim df
-#> All data 0.09649963       9 20
-#> parent   0.04721283       2  6
-#> M1       0.26551208       2  5
-#> M2       0.20327575       2  5
-#> M3       0.05196550       3  4
-  # }
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/tex_listing.html b/docs/dev/reference/tex_listing.html deleted file mode 100644 index 03bd83f2..00000000 --- a/docs/dev/reference/tex_listing.html +++ /dev/null @@ -1,143 +0,0 @@ - -Wrap the output of a summary function in tex listing environment — tex_listing • mkin - - -
-
- - - -
-
-
-

Wrap the output of a summary function in tex listing environment

- Source: R/tex_listing.R - -
- -
-

This function can be used in a R markdown code chunk with the chunk -option results = "asis".

-
- -
- 
tex_listing(object, caption = NULL, label = NULL, clearpage = TRUE)
-
- -
-

Arguments

-
object
-

The object for which the summary is to be listed

- - -
caption
-

An optional caption

- - -
label
-

An optional label

- - -
clearpage
-

Should a new page be started after the listing?

- -
- -
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.6.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/tffm0.html b/docs/dev/reference/tffm0.html deleted file mode 100644 index 8988b5a2..00000000 --- a/docs/dev/reference/tffm0.html +++ /dev/null @@ -1,158 +0,0 @@ - -Transform formation fractions as in the first published mkin version — tffm0 • mkin - - -
-
- - - -
-
-
-

Transform formation fractions as in the first published mkin version

- Source: R/tffm0.R - -
- -
-

The transformed fractions can be restricted between 0 and 1 in model -optimisations. Therefore this transformation was used originally in mkin. It -was later replaced by the ilr transformation because the ilr transformed -fractions can assumed to follow normal distribution. As the ilr -transformation is not available in RxODE and can therefore not be used in -the nlmixr modelling language, this transformation is currently used for -translating mkin models with formation fractions to more than one target -compartment for fitting with nlmixr in nlmixr_model. However, -this implementation cannot be used there, as it is not accessible -from RxODE.

-
- -
- 
tffm0(ff)
-
-invtffm0(ff_trans)
-
- -
-

Arguments

-
ff
-

Vector of untransformed formation fractions. The sum -must be smaller or equal to one

-
ff_trans
-

Vector of transformed formation fractions that can be -restricted to the interval from 0 to 1

-
-
-

Value

-

A vector of the transformed formation fractions -A vector of backtransformed formation fractions for natural use in degradation models

-
- -
-

Examples

- 
ff_example <- c(
-  0.10983681, 0.09035905, 0.08399383
-)
-ff_example_trans <- tffm0(ff_example)
-invtffm0(ff_example_trans)
-#> [1] 0.10983681 0.09035905 0.08399383
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.2.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/transform_odeparms.html b/docs/dev/reference/transform_odeparms.html deleted file mode 100644 index 4cb2e575..00000000 --- a/docs/dev/reference/transform_odeparms.html +++ /dev/null @@ -1,336 +0,0 @@ - -Functions to transform and backtransform kinetic parameters for fitting — transform_odeparms • mkin - - -
-
- - - -
-
-
-

Functions to transform and backtransform kinetic parameters for fitting

- Source: R/transform_odeparms.R - -
- -
-

The transformations are intended to map parameters that should only take on -restricted values to the full scale of real numbers. For kinetic rate -constants and other parameters that can only take on positive values, a -simple log transformation is used. For compositional parameters, such as the -formations fractions that should always sum up to 1 and can not be negative, -the ilr transformation is used.

-
- -
- 
transform_odeparms(
-  parms,
-  mkinmod,
-  transform_rates = TRUE,
-  transform_fractions = TRUE
-)
-
-backtransform_odeparms(
-  transparms,
-  mkinmod,
-  transform_rates = TRUE,
-  transform_fractions = TRUE
-)
-
- -
-

Arguments

-
parms
-

Parameters of kinetic models as used in the differential -equations.

- - -
mkinmod
-

The kinetic model of class mkinmod, containing -the names of the model variables that are needed for grouping the -formation fractions before ilr transformation, the parameter -names and the information if the pathway to sink is included in the model.

- - -
transform_rates
-

Boolean specifying if kinetic rate constants should -be transformed in the model specification used in the fitting for better -compliance with the assumption of normal distribution of the estimator. If -TRUE, also alpha and beta parameters of the FOMC model are -log-transformed, as well as k1 and k2 rate constants for the DFOP and HS -models and the break point tb of the HS model.

- - -
transform_fractions
-

Boolean specifying if formation fractions -constants should be transformed in the model specification used in the -fitting for better compliance with the assumption of normal distribution -of the estimator. The default (TRUE) is to do transformations. -The g parameter of the DFOP model is also seen as a fraction. -If a single fraction is transformed (g parameter of DFOP or only a single -target variable e.g. a single metabolite plus a pathway to sink), a -logistic transformation is used stats::qlogis(). In other cases, i.e. if -two or more formation fractions need to be transformed whose sum cannot -exceed one, the ilr transformation is used.

- - -
transparms
-

Transformed parameters of kinetic models as used in the -fitting procedure.

- -
-
-

Value

- - -

A vector of transformed or backtransformed parameters

-
-
-

Details

-

The transformation of sets of formation fractions is fragile, as it supposes -the same ordering of the components in forward and backward transformation. -This is no problem for the internal use in mkinfit.

-
-
-

Author

-

Johannes Ranke

-
- -
-

Examples

- 

-SFO_SFO <- mkinmod(
-  parent = list(type = "SFO", to = "m1", sink = TRUE),
-  m1 = list(type = "SFO"), use_of_ff = "min")
-#> Temporary DLL for differentials generated and loaded
-
-# Fit the model to the FOCUS example dataset D using defaults
-FOCUS_D <- subset(FOCUS_2006_D, value != 0) # remove zero values to avoid warning
-fit <- mkinfit(SFO_SFO, FOCUS_D, quiet = TRUE)
-fit.s <- summary(fit)
-# Transformed and backtransformed parameters
-print(fit.s$par, 3)
-#>                   Estimate Std. Error Lower  Upper
-#> parent_0             99.60     1.5702 96.40 102.79
-#> log_k_parent_sink    -3.04     0.0763 -3.19  -2.88
-#> log_k_parent_m1      -2.98     0.0403 -3.06  -2.90
-#> log_k_m1_sink        -5.25     0.1332 -5.52  -4.98
-#> sigma                 3.13     0.3585  2.40   3.85
-print(fit.s$bpar, 3)
-#>               Estimate se_notrans t value   Pr(>t)    Lower    Upper
-#> parent_0      99.59848    1.57022   63.43 2.30e-36 96.40384 102.7931
-#> k_parent_sink  0.04792    0.00365   13.11 6.13e-15  0.04103   0.0560
-#> k_parent_m1    0.05078    0.00205   24.80 3.27e-23  0.04678   0.0551
-#> k_m1_sink      0.00526    0.00070    7.51 6.16e-09  0.00401   0.0069
-#> sigma          3.12550    0.35852    8.72 2.24e-10  2.39609   3.8549
-
-# \dontrun{
-# Compare to the version without transforming rate parameters (does not work
-# with analytical solution, we get NA values for m1 in predictions)
-fit.2 <- mkinfit(SFO_SFO, FOCUS_D, transform_rates = FALSE,
-  solution_type = "deSolve", quiet = TRUE)
-fit.2.s <- summary(fit.2)
-print(fit.2.s$par, 3)
-#>               Estimate Std. Error    Lower    Upper
-#> parent_0      99.59848    1.57022 96.40384 1.03e+02
-#> k_parent_sink  0.04792    0.00365  0.04049 5.54e-02
-#> k_parent_m1    0.05078    0.00205  0.04661 5.49e-02
-#> k_m1_sink      0.00526    0.00070  0.00384 6.69e-03
-#> sigma          3.12550    0.35852  2.39609 3.85e+00
-print(fit.2.s$bpar, 3)
-#>               Estimate se_notrans t value   Pr(>t)    Lower    Upper
-#> parent_0      99.59848    1.57022   63.43 2.30e-36 96.40384 1.03e+02
-#> k_parent_sink  0.04792    0.00365   13.11 6.13e-15  0.04049 5.54e-02
-#> k_parent_m1    0.05078    0.00205   24.80 3.27e-23  0.04661 5.49e-02
-#> k_m1_sink      0.00526    0.00070    7.51 6.16e-09  0.00384 6.69e-03
-#> sigma          3.12550    0.35852    8.72 2.24e-10  2.39609 3.85e+00
-# }
-
-initials <- fit$start$value
-names(initials) <- rownames(fit$start)
-transformed <- fit$start_transformed$value
-names(transformed) <- rownames(fit$start_transformed)
-transform_odeparms(initials, SFO_SFO)
-#>          parent_0 log_k_parent_sink   log_k_parent_m1     log_k_m1_sink 
-#>        100.750000         -2.302585         -2.301586         -2.300587 
-backtransform_odeparms(transformed, SFO_SFO)
-#>      parent_0 k_parent_sink   k_parent_m1     k_m1_sink 
-#>      100.7500        0.1000        0.1001        0.1002 
-
-# \dontrun{
-# The case of formation fractions (this is now the default)
-SFO_SFO.ff <- mkinmod(
-  parent = list(type = "SFO", to = "m1", sink = TRUE),
-  m1 = list(type = "SFO"),
-  use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-fit.ff <- mkinfit(SFO_SFO.ff, FOCUS_D, quiet = TRUE)
-fit.ff.s <- summary(fit.ff)
-print(fit.ff.s$par, 3)
-#>                 Estimate Std. Error  Lower  Upper
-#> parent_0         99.5985     1.5702 96.404 102.79
-#> log_k_parent     -2.3157     0.0409 -2.399  -2.23
-#> log_k_m1         -5.2475     0.1332 -5.518  -4.98
-#> f_parent_qlogis   0.0579     0.0893 -0.124   0.24
-#> sigma             3.1255     0.3585  2.396   3.85
-print(fit.ff.s$bpar, 3)
-#>                Estimate se_notrans t value   Pr(>t)    Lower    Upper
-#> parent_0       99.59848    1.57022   63.43 2.30e-36 96.40383 102.7931
-#> k_parent        0.09870    0.00403   24.47 4.96e-23  0.09082   0.1073
-#> k_m1            0.00526    0.00070    7.51 6.16e-09  0.00401   0.0069
-#> f_parent_to_m1  0.51448    0.02230   23.07 3.10e-22  0.46912   0.5596
-#> sigma           3.12550    0.35852    8.72 2.24e-10  2.39609   3.8549
-initials <- c("f_parent_to_m1" = 0.5)
-transformed <- transform_odeparms(initials, SFO_SFO.ff)
-backtransform_odeparms(transformed, SFO_SFO.ff)
-#> f_parent_to_m1 
-#>            0.5 
-
-# And without sink
-SFO_SFO.ff.2 <- mkinmod(
-  parent = list(type = "SFO", to = "m1", sink = FALSE),
-  m1 = list(type = "SFO"),
-  use_of_ff = "max")
-#> Temporary DLL for differentials generated and loaded
-
-
-fit.ff.2 <- mkinfit(SFO_SFO.ff.2, FOCUS_D, quiet = TRUE)
-fit.ff.2.s <- summary(fit.ff.2)
-print(fit.ff.2.s$par, 3)
-#>              Estimate Std. Error Lower Upper
-#> parent_0        84.79      3.012 78.67 90.91
-#> log_k_parent    -2.76      0.082 -2.92 -2.59
-#> log_k_m1        -4.21      0.123 -4.46 -3.96
-#> sigma            8.22      0.943  6.31 10.14
-print(fit.ff.2.s$bpar, 3)
-#>          Estimate se_notrans t value   Pr(>t)   Lower  Upper
-#> parent_0  84.7916    3.01203   28.15 1.92e-25 78.6704 90.913
-#> k_parent   0.0635    0.00521   12.19 2.91e-14  0.0538  0.075
-#> k_m1       0.0148    0.00182    8.13 8.81e-10  0.0115  0.019
-#> sigma      8.2229    0.94323    8.72 1.73e-10  6.3060 10.140
-# }
-
-
-
-
- -
- - -
-

Developed by Johannes Ranke.

-
- -
-

Site built with pkgdown 2.0.7.

-
- -
- - - - - - - - diff --git a/docs/dev/reference/update.mkinfit-1.png b/docs/dev/reference/update.mkinfit-1.png deleted file mode 100644 index 9278aefd..00000000 Binary files a/docs/dev/reference/update.mkinfit-1.png and /dev/null differ diff --git a/docs/dev/reference/update.mkinfit-2.png b/docs/dev/reference/update.mkinfit-2.png deleted file mode 100644 index f73a6180..00000000 Binary files a/docs/dev/reference/update.mkinfit-2.png and /dev/null differ diff --git a/docs/dev/reference/update.mkinfit.html b/docs/dev/reference/update.mkinfit.html deleted file mode 100644 index 90aa0edb..00000000 --- a/docs/dev/reference/update.mkinfit.html +++ /dev/null @@ -1,181 +0,0 @@ - -Update an mkinfit model with different arguments — update.mkinfit • mkin - - -
-
- - - -
-
-
-

Update an mkinfit model with different arguments

- Source: R/update.mkinfit.R - -
- -
-

This function will return an updated mkinfit object. The fitted degradation -model parameters from the old fit are used as starting values for the -updated fit. Values specified as 'parms.ini' and/or 'state.ini' will -override these starting values.

-
- -
- 
# S3 method for mkinfit
-update(object, ..., evaluate = TRUE)
-
- -
-

Arguments

-
object
-

An mkinfit object to be updated

- - -
...
-

Arguments to mkinfit that should replace -the arguments from the original call. Arguments set to NULL will -remove arguments given in the original call

- - -
evaluate
-

Should the call be evaluated or returned as a call

- -
- -
-

Examples

- 
# \dontrun{
-fit <- mkinfit("SFO", subset(FOCUS_2006_D, value != 0), quiet = TRUE)
-parms(fit)
-#>    parent_0    k_parent       sigma 
-#> 99.44423885  0.09793574  3.39632469 
-plot_err(fit)
-
-fit_2 <- update(fit, error_model = "tc")
-parms(fit_2)
-#>     parent_0     k_parent    sigma_low     rsd_high 
-#> 1.008549e+02 1.005665e-01 3.752222e-03 6.763434e-02 
-plot_err(fit_2)
-
-# }
-
-
-
- -
- - -
- - - - - - - - -- cgit v1.2.1