From 4596667b19f032232ceb8f3f762aaad5d69c15be Mon Sep 17 00:00:00 2001 From: Johannes Ranke Date: Fri, 5 Jul 2019 15:57:24 +0200 Subject: Static documentation rebuilt by pkgdown --- docs/index.html | 7 ++++--- 1 file changed, 4 insertions(+), 3 deletions(-) (limited to 'docs/index.html') diff --git a/docs/index.html b/docs/index.html index e3f3b376..85a0bbfc 100644 --- a/docs/index.html +++ b/docs/index.html @@ -37,7 +37,7 @@ mkin - 0.9.49.5 + 0.9.49.6 @@ -130,9 +130,10 @@
  • The usual one-sided t-test for significant difference from zero is nevertheless shown based on estimators for the untransformed parameters.
  • Summary and plotting functions. The summary of an mkinfit object is in fact a full report that should give enough information to be able to approximately reproduce the fit with other tools.
  • The chi-squared error level as defined in the FOCUS kinetics guidance (see below) is calculated for each observed variable.
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  • Iteratively reweighted least squares fitting is implemented in a similar way as in KinGUII and CAKE (see below). Simply add the argument reweight.method = "obs" to your call to mkinfit and a separate variance componenent for each of the observed variables will be optimised in a second stage after the primary optimisation algorithm has converged.
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  • Iterative reweighting is also possible using a two-component error model for analytical data similar to the one proposed by Rocke and Lorenzato using the argument reweight.method = "tc".
  • When a metabolite decline phase is not described well by SFO kinetics, SFORB kinetics can be used for the metabolite.
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  • Three different error models can be selected using the argument error_model to the mkinfit function.
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  • Iteratively reweighted least squares fitting is now obsolete, and the variance by variable error model should now be specified as error_model = "obs".
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  • A two-component error model similar to the one proposed by Rocke and Lorenzato can be selected using the argument error_model = "tc".
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