From c322a8102a399cbb1fe38c4c4ca4485cea8bc4e8 Mon Sep 17 00:00:00 2001
From: Johannes Ranke <jranke@uni-bremen.de>
Date: Tue, 7 May 2019 08:43:12 +0200
Subject: Fix hessian calculations

Static documentation rebuilt by pkgdown
---
 docs/reference/NAFTA_SOP_2015.html          |  32 ++---
 docs/reference/NAFTA_SOP_Attachment.html    |  32 ++---
 docs/reference/logistic.solution.html       |  18 ++-
 docs/reference/mccall81_245T.html           |  45 ++++---
 docs/reference/mkinfit.html                 | 176 ++++++++++++++++------------
 docs/reference/mkinmod.html                 |   2 +-
 docs/reference/mkinparplot-1.png            | Bin 17306 -> 16549 bytes
 docs/reference/mkinparplot.html             |   2 +-
 docs/reference/mkinpredict.html             |   4 +-
 docs/reference/mmkin.html                   |   4 +-
 docs/reference/nafta.html                   |  32 ++---
 docs/reference/summary.mkinfit.html         |  30 +++--
 docs/reference/test_data_from_UBA_2014.html |  54 ++++++---
 docs/reference/transform_odeparms.html      |  90 +++++++-------
 14 files changed, 300 insertions(+), 221 deletions(-)

(limited to 'docs/reference')

diff --git a/docs/reference/NAFTA_SOP_2015.html b/docs/reference/NAFTA_SOP_2015.html
index 9fbc71c6..84341a17 100644
--- a/docs/reference/NAFTA_SOP_2015.html
+++ b/docs/reference/NAFTA_SOP_2015.html
@@ -155,7 +155,7 @@
     
 
     <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>  <span class='no'>nafta_evaluation</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='nafta.html'>nafta</a></span>(<span class='no'>NAFTA_SOP_Appendix_D</span>, <span class='kw'>cores</span> <span class='kw'>=</span> <span class='fl'>1</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; <span class='message'>The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></div><div class='output co'>#&gt; <span class='message'>The representative half-life of the IORE model is longer than the one corresponding</span></div><div class='output co'>#&gt; <span class='message'>to the terminal degradation rate found with the DFOP model.</span></div><div class='output co'>#&gt; <span class='message'>The representative half-life obtained from the DFOP model may be used</span></div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>nafta_evaluation</span>)</div><div class='output co'>#&gt; Sums of squares:
+    <pre class="examples"><div class='input'>  <span class='no'>nafta_evaluation</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='nafta.html'>nafta</a></span>(<span class='no'>NAFTA_SOP_Appendix_D</span>, <span class='kw'>cores</span> <span class='kw'>=</span> <span class='fl'>1</span>)</div><div class='output co'>#&gt; <span class='message'>The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></div><div class='output co'>#&gt; <span class='message'>The representative half-life of the IORE model is longer than the one corresponding</span></div><div class='output co'>#&gt; <span class='message'>to the terminal degradation rate found with the DFOP model.</span></div><div class='output co'>#&gt; <span class='message'>The representative half-life obtained from the DFOP model may be used</span></div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>nafta_evaluation</span>)</div><div class='output co'>#&gt; Sums of squares:
 #&gt;       SFO      IORE      DFOP 
 #&gt; 1378.6832  615.7730  517.8836 
 #&gt; 
@@ -164,25 +164,25 @@
 #&gt; 
 #&gt; Parameters:
 #&gt; $SFO
-#&gt;               Estimate Pr(&gt;t) Lower Upper
-#&gt; parent_0       83.7558     NA    NA    NA
-#&gt; k_parent_sink   0.0017     NA    NA    NA
-#&gt; sigma           8.7518     NA    NA    NA
+#&gt;               Estimate   Pr(&gt;t)    Lower   Upper
+#&gt; parent_0       83.7558 1.80e-14 77.18268 90.3288
+#&gt; k_parent_sink   0.0017 7.43e-05  0.00112  0.0026
+#&gt; sigma           8.7518 1.22e-05  5.64278 11.8608
 #&gt; 
 #&gt; $IORE
-#&gt;                     Estimate Pr(&gt;t) Lower Upper
-#&gt; parent_0            9.69e+01     NA    NA    NA
-#&gt; k__iore_parent_sink 8.40e-14     NA    NA    NA
-#&gt; N_parent            6.68e+00     NA    NA    NA
-#&gt; sigma               5.85e+00     NA    NA    NA
+#&gt;                     Estimate Pr(&gt;t)    Lower    Upper
+#&gt; parent_0            9.69e+01     NA 8.88e+01 1.05e+02
+#&gt; k__iore_parent_sink 8.40e-14     NA 1.79e-18 3.94e-09
+#&gt; N_parent            6.68e+00     NA 4.19e+00 9.17e+00
+#&gt; sigma               5.85e+00     NA 3.76e+00 7.94e+00
 #&gt; 
 #&gt; $DFOP
-#&gt;          Estimate Pr(&gt;t) Lower Upper
-#&gt; parent_0 9.76e+01     NA    NA    NA
-#&gt; k1       4.24e-02     NA    NA    NA
-#&gt; k2       8.24e-04     NA    NA    NA
-#&gt; g        2.88e-01     NA    NA    NA
-#&gt; sigma    5.36e+00     NA    NA    NA
+#&gt;          Estimate   Pr(&gt;t)    Lower    Upper
+#&gt; parent_0 9.76e+01 1.94e-13 9.02e+01 1.05e+02
+#&gt; k1       4.24e-02 5.92e-03 2.03e-02 8.88e-02
+#&gt; k2       8.24e-04 6.48e-03 3.89e-04 1.75e-03
+#&gt; g        2.88e-01 2.47e-05 1.95e-01 4.03e-01
+#&gt; sigma    5.36e+00 2.22e-05 3.43e+00 7.30e+00
 #&gt; 
 #&gt; 
 #&gt; DTx values:
diff --git a/docs/reference/NAFTA_SOP_Attachment.html b/docs/reference/NAFTA_SOP_Attachment.html
index 149b4d82..76d91c40 100644
--- a/docs/reference/NAFTA_SOP_Attachment.html
+++ b/docs/reference/NAFTA_SOP_Attachment.html
@@ -152,7 +152,7 @@
     
 
     <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>  <span class='no'>nafta_att_p5a</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='nafta.html'>nafta</a></span>(<span class='no'>NAFTA_SOP_Attachment</span><span class='kw'>[[</span><span class='st'>"p5a"</span>]], <span class='kw'>cores</span> <span class='kw'>=</span> <span class='fl'>1</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; <span class='message'>The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></div><div class='output co'>#&gt; <span class='message'>The half-life obtained from the IORE model may be used</span></div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>nafta_att_p5a</span>)</div><div class='output co'>#&gt; Sums of squares:
+    <pre class="examples"><div class='input'>  <span class='no'>nafta_att_p5a</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='nafta.html'>nafta</a></span>(<span class='no'>NAFTA_SOP_Attachment</span><span class='kw'>[[</span><span class='st'>"p5a"</span>]], <span class='kw'>cores</span> <span class='kw'>=</span> <span class='fl'>1</span>)</div><div class='output co'>#&gt; <span class='message'>The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></div><div class='output co'>#&gt; <span class='message'>The half-life obtained from the IORE model may be used</span></div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>nafta_att_p5a</span>)</div><div class='output co'>#&gt; Sums of squares:
 #&gt;       SFO      IORE      DFOP 
 #&gt; 465.21753  56.27506  32.06401 
 #&gt; 
@@ -161,25 +161,25 @@
 #&gt; 
 #&gt; Parameters:
 #&gt; $SFO
-#&gt;               Estimate Pr(&gt;t) Lower Upper
-#&gt; parent_0       95.8401     NA    NA    NA
-#&gt; k_parent_sink   0.0102     NA    NA    NA
-#&gt; sigma           4.8230     NA    NA    NA
+#&gt;               Estimate   Pr(&gt;t)  Lower   Upper
+#&gt; parent_0       95.8401 4.67e-21 92.245 99.4357
+#&gt; k_parent_sink   0.0102 3.92e-12  0.009  0.0117
+#&gt; sigma           4.8230 3.81e-06  3.214  6.4318
 #&gt; 
 #&gt; $IORE
-#&gt;                     Estimate Pr(&gt;t) Lower Upper
-#&gt; parent_0            1.01e+02     NA    NA    NA
-#&gt; k__iore_parent_sink 1.54e-05     NA    NA    NA
-#&gt; N_parent            2.57e+00     NA    NA    NA
-#&gt; sigma               1.68e+00     NA    NA    NA
+#&gt;                     Estimate Pr(&gt;t)    Lower    Upper
+#&gt; parent_0            1.01e+02     NA 9.91e+01 1.02e+02
+#&gt; k__iore_parent_sink 1.54e-05     NA 4.08e-06 5.84e-05
+#&gt; N_parent            2.57e+00     NA 2.25e+00 2.89e+00
+#&gt; sigma               1.68e+00     NA 1.12e+00 2.24e+00
 #&gt; 
 #&gt; $DFOP
-#&gt;          Estimate Pr(&gt;t) Lower Upper
-#&gt; parent_0 9.99e+01     NA    NA    NA
-#&gt; k1       2.67e-02     NA    NA    NA
-#&gt; k2       2.86e-12     NA    NA    NA
-#&gt; g        6.47e-01     NA    NA    NA
-#&gt; sigma    1.27e+00     NA    NA    NA
+#&gt;          Estimate   Pr(&gt;t)   Lower    Upper
+#&gt; parent_0 9.99e+01 1.41e-26 98.8116 101.0810
+#&gt; k1       2.67e-02 5.05e-06  0.0243   0.0295
+#&gt; k2       2.86e-12 5.00e-01  0.0000      Inf
+#&gt; g        6.47e-01 3.67e-06  0.6248   0.6677
+#&gt; sigma    1.27e+00 8.91e-06  0.8395   1.6929
 #&gt; 
 #&gt; 
 #&gt; DTx values:
diff --git a/docs/reference/logistic.solution.html b/docs/reference/logistic.solution.html
index 082cd4fb..3b45b14f 100644
--- a/docs/reference/logistic.solution.html
+++ b/docs/reference/logistic.solution.html
@@ -205,12 +205,18 @@
     <span class='kw'>n</span> <span class='kw'>=</span> <span class='fl'>1</span>, <span class='kw'>reps</span> <span class='kw'>=</span> <span class='fl'>2</span>, <span class='kw'>digits</span> <span class='kw'>=</span> <span class='fl'>5</span>, <span class='kw'>LOD</span> <span class='kw'>=</span> <span class='fl'>0.1</span>, <span class='kw'>seed</span> <span class='kw'>=</span> <span class='fl'>123456</span>)<span class='kw'>[[</span><span class='fl'>1</span>]]
 
   <span class='no'>m</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='st'>"logistic"</span>, <span class='no'>d_2_1</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)
-  <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span>(<span class='no'>m</span>)</div><div class='img'><img src='logistic.solution-2.png' alt='' width='700' height='433' /></div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>m</span>)$<span class='no'>bpar</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt;              Estimate se_notrans t value Pr(&gt;t) Lower Upper
-#&gt; parent_0 1.057896e+02         NA      NA     NA    NA    NA
-#&gt; kmax     6.398190e-02         NA      NA     NA    NA    NA
-#&gt; k0       1.612775e-04         NA      NA     NA    NA    NA
-#&gt; r        2.263946e-01         NA      NA     NA    NA    NA
-#&gt; sigma    5.332935e+00         NA      NA     NA    NA    NA</div><div class='input'>  <span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>m</span>)$<span class='no'>distimes</span></div><div class='output co'>#&gt;            DT50     DT90  DT50_k0 DT50_kmax
+  <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span>(<span class='no'>m</span>)</div><div class='img'><img src='logistic.solution-2.png' alt='' width='700' height='433' /></div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>m</span>)$<span class='no'>bpar</span></div><div class='output co'>#&gt;              Estimate   se_notrans   t value       Pr(&gt;t)        Lower
+#&gt; parent_0 1.057896e+02 1.9023449649 55.610120 3.768361e-16 1.016451e+02
+#&gt; kmax     6.398190e-02 0.0143201029  4.467978 3.841828e-04 3.929235e-02
+#&gt; k0       1.612775e-04 0.0005866813  0.274898 3.940351e-01 5.846685e-08
+#&gt; r        2.263946e-01 0.1718110773  1.317695 1.061044e-01 4.335843e-02
+#&gt; sigma    5.332935e+00 0.9145907310  5.830952 4.036926e-05 3.340213e+00
+#&gt;                Upper
+#&gt; parent_0 109.9341588
+#&gt; kmax       0.1041853
+#&gt; k0         0.4448750
+#&gt; r          1.1821121
+#&gt; sigma      7.3256566</div><div class='input'>  <span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>m</span>)$<span class='no'>distimes</span></div><div class='output co'>#&gt;            DT50     DT90  DT50_k0 DT50_kmax
 #&gt; parent 36.86533 62.41511 4297.854  10.83349</div></pre>
   </div>
   <div class="col-md-3 hidden-xs hidden-sm" id="sidebar">
diff --git a/docs/reference/mccall81_245T.html b/docs/reference/mccall81_245T.html
index 26bbd2ec..1db9a9d9 100644
--- a/docs/reference/mccall81_245T.html
+++ b/docs/reference/mccall81_245T.html
@@ -160,14 +160,22 @@
     <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
     <pre class="examples"><div class='input'>  <span class='no'>SFO_SFO_SFO</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(<span class='kw'>T245</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/list'>list</a></span>(<span class='kw'>type</span> <span class='kw'>=</span> <span class='st'>"SFO"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"phenol"</span>),
                          <span class='kw'>phenol</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/list'>list</a></span>(<span class='kw'>type</span> <span class='kw'>=</span> <span class='st'>"SFO"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"anisole"</span>),
-                         <span class='kw'>anisole</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/list'>list</a></span>(<span class='kw'>type</span> <span class='kw'>=</span> <span class='st'>"SFO"</span>))</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'>  </div><div class='input'>    <span class='no'>fit.1</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO_SFO</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/subset'>subset</a></span>(<span class='no'>mccall81_245T</span>, <span class='no'>soil</span> <span class='kw'>==</span> <span class='st'>"Commerce"</span>), <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'>    <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit.1</span>)$<span class='no'>bpar</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt;                      Estimate se_notrans t value Pr(&gt;t) Lower Upper
-#&gt; T245_0           1.038550e+02         NA      NA     NA    NA    NA
-#&gt; k_T245_sink      1.636106e-02         NA      NA     NA    NA    NA
-#&gt; k_T245_phenol    2.700936e-02         NA      NA     NA    NA    NA
-#&gt; k_phenol_sink    1.788604e-10         NA      NA     NA    NA    NA
-#&gt; k_phenol_anisole 4.050581e-01         NA      NA     NA    NA    NA
-#&gt; k_anisole_sink   6.678742e-03         NA      NA     NA    NA    NA
-#&gt; sigma            2.514628e+00         NA      NA     NA    NA    NA</div><div class='input'>    <span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>fit.1</span>)</div><div class='output co'>#&gt; $ff
+                         <span class='kw'>anisole</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/list'>list</a></span>(<span class='kw'>type</span> <span class='kw'>=</span> <span class='st'>"SFO"</span>))</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'>  </div><div class='input'>    <span class='no'>fit.1</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO_SFO</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/subset'>subset</a></span>(<span class='no'>mccall81_245T</span>, <span class='no'>soil</span> <span class='kw'>==</span> <span class='st'>"Commerce"</span>), <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'>    <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit.1</span>)$<span class='no'>bpar</span></div><div class='output co'>#&gt; <span class='warning'>Warning: NaNs wurden erzeugt</span></div><div class='output co'>#&gt;                      Estimate   se_notrans   t value       Pr(&gt;t)        Lower
+#&gt; T245_0           1.038550e+02 2.1508110557 48.286452 3.542232e-18 99.246062215
+#&gt; k_T245_sink      1.636106e-02          NaN       NaN          NaN  0.012661558
+#&gt; k_T245_phenol    2.700936e-02          NaN       NaN          NaN  0.024487315
+#&gt; k_phenol_sink    1.788604e-10          NaN       NaN          NaN  0.000000000
+#&gt; k_phenol_anisole 4.050581e-01 0.1053801116  3.843781 7.970202e-04  0.218013982
+#&gt; k_anisole_sink   6.678742e-03 0.0006205844 10.762020 9.428076e-09  0.005370739
+#&gt; sigma            2.514628e+00 0.3383670685  7.431657 1.054101e-06  1.706607296
+#&gt;                         Upper
+#&gt; T245_0           1.084640e+02
+#&gt; k_T245_sink      2.114150e-02
+#&gt; k_T245_phenol    2.979116e-02
+#&gt; k_phenol_sink             Inf
+#&gt; k_phenol_anisole 7.525759e-01
+#&gt; k_anisole_sink   8.305299e-03
+#&gt; sigma            3.322649e+00</div><div class='input'>    <span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>fit.1</span>)</div><div class='output co'>#&gt; $ff
 #&gt;      T245_sink    T245_phenol    phenol_sink phenol_anisole   anisole_sink 
 #&gt;   3.772401e-01   6.227599e-01   4.415672e-10   1.000000e+00   1.000000e+00 
 #&gt; 
@@ -182,13 +190,20 @@
 #&gt; </div><div class='input'>    <span class='co'># k_phenol_sink is really small, therefore fix it to zero</span>
     <span class='no'>fit.2</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO_SFO</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/subset'>subset</a></span>(<span class='no'>mccall81_245T</span>, <span class='no'>soil</span> <span class='kw'>==</span> <span class='st'>"Commerce"</span>),
                    <span class='kw'>parms.ini</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='kw'>k_phenol_sink</span> <span class='kw'>=</span> <span class='fl'>0</span>),
-                   <span class='kw'>fixed_parms</span> <span class='kw'>=</span> <span class='st'>"k_phenol_sink"</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'>    <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit.2</span>)$<span class='no'>bpar</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt;                      Estimate se_notrans t value Pr(&gt;t) Lower Upper
-#&gt; T245_0           1.038550e+02         NA      NA     NA    NA    NA
-#&gt; k_T245_sink      1.636106e-02         NA      NA     NA    NA    NA
-#&gt; k_T245_phenol    2.700936e-02         NA      NA     NA    NA    NA
-#&gt; k_phenol_anisole 4.050581e-01         NA      NA     NA    NA    NA
-#&gt; k_anisole_sink   6.678742e-03         NA      NA     NA    NA    NA
-#&gt; sigma            2.514628e+00         NA      NA     NA    NA    NA</div><div class='input'>    <span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>fit.1</span>)</div><div class='output co'>#&gt; $ff
+                   <span class='kw'>fixed_parms</span> <span class='kw'>=</span> <span class='st'>"k_phenol_sink"</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'>    <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit.2</span>)$<span class='no'>bpar</span></div><div class='output co'>#&gt;                      Estimate   se_notrans   t value       Pr(&gt;t)        Lower
+#&gt; T245_0           1.038550e+02 2.1623653063 48.028441 4.993105e-19 99.271025146
+#&gt; k_T245_sink      1.636106e-02 0.0019676255  8.315130 1.673674e-07  0.012679148
+#&gt; k_T245_phenol    2.700936e-02 0.0012421966 21.743224 1.314080e-13  0.024500319
+#&gt; k_phenol_anisole 4.050581e-01 0.1177235488  3.440757 1.679237e-03  0.218746679
+#&gt; k_anisole_sink   6.678742e-03 0.0006829745  9.778904 1.872892e-08  0.005377084
+#&gt; sigma            2.514628e+00 0.3790944250  6.633250 2.875782e-06  1.710983655
+#&gt;                         Upper
+#&gt; T245_0           108.43904395
+#&gt; k_T245_sink        0.02111217
+#&gt; k_T245_phenol      0.02977535
+#&gt; k_phenol_anisole   0.75005504
+#&gt; k_anisole_sink     0.00829550
+#&gt; sigma              3.31827222</div><div class='input'>    <span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>fit.1</span>)</div><div class='output co'>#&gt; $ff
 #&gt;      T245_sink    T245_phenol    phenol_sink phenol_anisole   anisole_sink 
 #&gt;   3.772401e-01   6.227599e-01   4.415672e-10   1.000000e+00   1.000000e+00 
 #&gt; 
diff --git a/docs/reference/mkinfit.html b/docs/reference/mkinfit.html
index b75b7c95..09329a86 100644
--- a/docs/reference/mkinfit.html
+++ b/docs/reference/mkinfit.html
@@ -360,17 +360,17 @@ Per default, parameters in the kinetic models are internally transformed in
     <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
     <pre class="examples"><div class='input'><span class='co'># Use shorthand notation for parent only degradation</span>
 <span class='no'>fit</span> <span class='kw'>&lt;-</span> <span class='fu'>mkinfit</span>(<span class='st'>"FOMC"</span>, <span class='no'>FOCUS_2006_C</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)
-<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; mkin version used for fitting:    0.9.49.4 
+<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit</span>)</div><div class='output co'>#&gt; mkin version used for fitting:    0.9.49.4 
 #&gt; R version used for fitting:       3.6.0 
-#&gt; Date of fit:     Tue May  7 08:08:23 2019 
-#&gt; Date of summary: Tue May  7 08:08:23 2019 
+#&gt; Date of fit:     Tue May  7 08:36:16 2019 
+#&gt; Date of summary: Tue May  7 08:36:16 2019 
 #&gt; 
 #&gt; Equations:
 #&gt; d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent
 #&gt; 
 #&gt; Model predictions using solution type analytical 
 #&gt; 
-#&gt; Fitted using 66 model solutions performed in 0.139 s
+#&gt; Fitted using 222 model solutions performed in 0.89 s
 #&gt; 
 #&gt; Error model:
 #&gt; Constant variance 
@@ -393,23 +393,28 @@ Per default, parameters in the kinetic models are internally transformed in
 #&gt; None
 #&gt; 
 #&gt; Optimised, transformed parameters with symmetric confidence intervals:
-#&gt;           Estimate Std. Error Lower Upper
-#&gt; parent_0  85.87000         NA    NA    NA
-#&gt; log_alpha  0.05192         NA    NA    NA
-#&gt; log_beta   0.65100         NA    NA    NA
-#&gt; sigma      1.85700         NA    NA    NA
+#&gt;           Estimate Std. Error    Lower   Upper
+#&gt; parent_0  85.87000     1.8070 81.23000 90.5200
+#&gt; log_alpha  0.05192     0.1353 -0.29580  0.3996
+#&gt; log_beta   0.65100     0.2287  0.06315  1.2390
+#&gt; sigma      1.85700     0.4378  0.73200  2.9830
 #&gt; 
 #&gt; Parameter correlation:
-#&gt; No covariance matrix
+#&gt;             parent_0  log_alpha   log_beta     sigma
+#&gt; parent_0   1.000e+00 -1.565e-01 -3.142e-01 4.770e-08
+#&gt; log_alpha -1.565e-01  1.000e+00  9.564e-01 9.974e-08
+#&gt; log_beta  -3.142e-01  9.564e-01  1.000e+00 8.468e-08
+#&gt; sigma      4.770e-08  9.974e-08  8.468e-08 1.000e+00
+#&gt; 
 #&gt; Backtransformed parameters:
 #&gt; Confidence intervals for internally transformed parameters are asymmetric.
 #&gt; t-test (unrealistically) based on the assumption of normal distribution
 #&gt; for estimators of untransformed parameters.
-#&gt;          Estimate t value Pr(&gt;t) Lower Upper
-#&gt; parent_0   85.870      NA     NA    NA    NA
-#&gt; alpha       1.053      NA     NA    NA    NA
-#&gt; beta        1.917      NA     NA    NA    NA
-#&gt; sigma       1.857      NA     NA    NA    NA
+#&gt;          Estimate t value    Pr(&gt;t)   Lower  Upper
+#&gt; parent_0   85.870  47.530 3.893e-08 81.2300 90.520
+#&gt; alpha       1.053   7.393 3.562e-04  0.7439  1.491
+#&gt; beta        1.917   4.373 3.601e-03  1.0650  3.451
+#&gt; sigma       1.857   4.243 4.074e-03  0.7320  2.983
 #&gt; 
 #&gt; FOCUS Chi2 error levels in percent:
 #&gt;          err.min n.optim df
@@ -438,7 +443,7 @@ Per default, parameters in the kinetic models are internally transformed in
   <span class='kw'>m1</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>))</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'><span class='co'># Fit the model to the FOCUS example dataset D using defaults</span>
 <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/system.time'>system.time</a></span>(<span class='no'>fit</span> <span class='kw'>&lt;-</span> <span class='fu'>mkinfit</span>(<span class='no'>SFO_SFO</span>, <span class='no'>FOCUS_2006_D</span>,
                            <span class='kw'>solution_type</span> <span class='kw'>=</span> <span class='st'>"eigen"</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)))</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='output co'>#&gt;        User      System verstrichen 
-#&gt;       0.637       0.000       0.640 </div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/stats/topics/coef'>coef</a></span>(<span class='no'>fit</span>)</div><div class='output co'>#&gt; NULL</div><div class='input'><span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>fit</span>)</div><div class='output co'>#&gt; $ff
+#&gt;       2.251       0.000       2.253 </div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/stats/topics/coef'>coef</a></span>(<span class='no'>fit</span>)</div><div class='output co'>#&gt; NULL</div><div class='input'><span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>fit</span>)</div><div class='output co'>#&gt; $ff
 #&gt; parent_sink   parent_m1     m1_sink 
 #&gt;    0.485524    0.514476    1.000000 
 #&gt; 
@@ -510,7 +515,7 @@ Per default, parameters in the kinetic models are internally transformed in
 #&gt; Sum of squared residuals at call 126: 371.2134
 #&gt; Sum of squared residuals at call 135: 371.2134
 #&gt; Negative log-likelihood at call 145: 97.22429</div><div class='output co'>#&gt; <span class='message'>Optimisation successfully terminated.</span></div><div class='output co'>#&gt;        User      System verstrichen 
-#&gt;       0.544       0.000       0.550 </div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/stats/topics/coef'>coef</a></span>(<span class='no'>fit.deSolve</span>)</div><div class='output co'>#&gt; NULL</div><div class='input'><span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>fit.deSolve</span>)</div><div class='output co'>#&gt; $ff
+#&gt;       1.151       0.000       1.152 </div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/stats/topics/coef'>coef</a></span>(<span class='no'>fit.deSolve</span>)</div><div class='output co'>#&gt; NULL</div><div class='input'><span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>fit.deSolve</span>)</div><div class='output co'>#&gt; $ff
 #&gt; parent_sink   parent_m1     m1_sink 
 #&gt;    0.485524    0.514476    1.000000 
 #&gt; 
@@ -540,10 +545,10 @@ Per default, parameters in the kinetic models are internally transformed in
 <span class='no'>fit.SFORB_SFO</span> <span class='kw'>&lt;-</span> <span class='fu'>mkinfit</span>(<span class='no'>SFORB_SFO</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>parms.ini</span> <span class='kw'>=</span> <span class='no'>fit.SFORB</span>$<span class='no'>bparms.ode</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'>
 </div><div class='input'><span class='co'># Weighted fits, including IRLS</span>
 <span class='no'>SFO_SFO.ff</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(<span class='kw'>parent</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>, <span class='st'>"m1"</span>),
-                      <span class='kw'>m1</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>), <span class='kw'>use_of_ff</span> <span class='kw'>=</span> <span class='st'>"max"</span>)</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'><span class='no'>f.noweight</span> <span class='kw'>&lt;-</span> <span class='fu'>mkinfit</span>(<span class='no'>SFO_SFO.ff</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>f.noweight</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; mkin version used for fitting:    0.9.49.4 
+                      <span class='kw'>m1</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>), <span class='kw'>use_of_ff</span> <span class='kw'>=</span> <span class='st'>"max"</span>)</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'><span class='no'>f.noweight</span> <span class='kw'>&lt;-</span> <span class='fu'>mkinfit</span>(<span class='no'>SFO_SFO.ff</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>f.noweight</span>)</div><div class='output co'>#&gt; mkin version used for fitting:    0.9.49.4 
 #&gt; R version used for fitting:       3.6.0 
-#&gt; Date of fit:     Tue May  7 08:08:30 2019 
-#&gt; Date of summary: Tue May  7 08:08:30 2019 
+#&gt; Date of fit:     Tue May  7 08:36:33 2019 
+#&gt; Date of summary: Tue May  7 08:36:33 2019 
 #&gt; 
 #&gt; Equations:
 #&gt; d_parent/dt = - k_parent * parent
@@ -551,7 +556,7 @@ Per default, parameters in the kinetic models are internally transformed in
 #&gt; 
 #&gt; Model predictions using solution type deSolve 
 #&gt; 
-#&gt; Fitted using 185 model solutions performed in 0.499 s
+#&gt; Fitted using 421 model solutions performed in 1.1 s
 #&gt; 
 #&gt; Error model:
 #&gt; Constant variance 
@@ -577,25 +582,31 @@ Per default, parameters in the kinetic models are internally transformed in
 #&gt; m1_0     0 state
 #&gt; 
 #&gt; Optimised, transformed parameters with symmetric confidence intervals:
-#&gt;                Estimate Std. Error Lower Upper
-#&gt; parent_0       99.60000         NA    NA    NA
-#&gt; log_k_parent   -2.31600         NA    NA    NA
-#&gt; log_k_m1       -5.24800         NA    NA    NA
-#&gt; f_parent_ilr_1  0.04096         NA    NA    NA
-#&gt; sigma           3.12600         NA    NA    NA
+#&gt;                Estimate Std. Error    Lower    Upper
+#&gt; parent_0       99.60000    1.57000 96.40000 102.8000
+#&gt; log_k_parent   -2.31600    0.04087 -2.39900  -2.2330
+#&gt; log_k_m1       -5.24800    0.13320 -5.51800  -4.9770
+#&gt; f_parent_ilr_1  0.04096    0.06312 -0.08746   0.1694
+#&gt; sigma           3.12600    0.35850  2.39600   3.8550
 #&gt; 
 #&gt; Parameter correlation:
-#&gt; No covariance matrix
+#&gt;                  parent_0 log_k_parent   log_k_m1 f_parent_ilr_1      sigma
+#&gt; parent_0        1.000e+00    5.174e-01 -1.688e-01     -5.471e-01 -2.265e-07
+#&gt; log_k_parent    5.174e-01    1.000e+00 -3.263e-01     -5.426e-01  3.785e-07
+#&gt; log_k_m1       -1.688e-01   -3.263e-01  1.000e+00      7.478e-01 -1.386e-07
+#&gt; f_parent_ilr_1 -5.471e-01   -5.426e-01  7.478e-01      1.000e+00 -3.641e-08
+#&gt; sigma          -2.265e-07    3.785e-07 -1.386e-07     -3.641e-08  1.000e+00
+#&gt; 
 #&gt; Backtransformed parameters:
 #&gt; Confidence intervals for internally transformed parameters are asymmetric.
 #&gt; t-test (unrealistically) based on the assumption of normal distribution
 #&gt; for estimators of untransformed parameters.
-#&gt;                 Estimate t value Pr(&gt;t) Lower Upper
-#&gt; parent_0       99.600000      NA     NA    NA    NA
-#&gt; k_parent        0.098700      NA     NA    NA    NA
-#&gt; k_m1            0.005261      NA     NA    NA    NA
-#&gt; f_parent_to_m1  0.514500      NA     NA    NA    NA
-#&gt; sigma           3.126000      NA     NA    NA    NA
+#&gt;                 Estimate t value    Pr(&gt;t)     Lower     Upper
+#&gt; parent_0       99.600000  63.430 2.298e-36 96.400000 1.028e+02
+#&gt; k_parent        0.098700  24.470 4.955e-23  0.090820 1.073e-01
+#&gt; k_m1            0.005261   7.510 6.165e-09  0.004012 6.898e-03
+#&gt; f_parent_to_m1  0.514500  23.070 3.104e-22  0.469100 5.596e-01
+#&gt; sigma           3.126000   8.718 2.235e-10  2.396000 3.855e+00
 #&gt; 
 #&gt; FOCUS Chi2 error levels in percent:
 #&gt;          err.min n.optim df
@@ -652,10 +663,10 @@ Per default, parameters in the kinetic models are internally transformed in
 #&gt;   100       m1    31.04  31.98163 -9.416e-01
 #&gt;   100       m1    33.13  31.98163  1.148e+00
 #&gt;   120       m1    25.15  28.78984 -3.640e+00
-#&gt;   120       m1    33.31  28.78984  4.520e+00</div><div class='input'><span class='no'>f.obs</span> <span class='kw'>&lt;-</span> <span class='fu'>mkinfit</span>(<span class='no'>SFO_SFO.ff</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>error_model</span> <span class='kw'>=</span> <span class='st'>"obs"</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>f.obs</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; mkin version used for fitting:    0.9.49.4 
+#&gt;   120       m1    33.31  28.78984  4.520e+00</div><div class='input'><span class='no'>f.obs</span> <span class='kw'>&lt;-</span> <span class='fu'>mkinfit</span>(<span class='no'>SFO_SFO.ff</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>error_model</span> <span class='kw'>=</span> <span class='st'>"obs"</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>f.obs</span>)</div><div class='output co'>#&gt; mkin version used for fitting:    0.9.49.4 
 #&gt; R version used for fitting:       3.6.0 
-#&gt; Date of fit:     Tue May  7 08:08:32 2019 
-#&gt; Date of summary: Tue May  7 08:08:32 2019 
+#&gt; Date of fit:     Tue May  7 08:36:35 2019 
+#&gt; Date of summary: Tue May  7 08:36:35 2019 
 #&gt; 
 #&gt; Equations:
 #&gt; d_parent/dt = - k_parent * parent
@@ -663,7 +674,7 @@ Per default, parameters in the kinetic models are internally transformed in
 #&gt; 
 #&gt; Model predictions using solution type deSolve 
 #&gt; 
-#&gt; Fitted using 426 model solutions performed in 1.139 s
+#&gt; Fitted using 758 model solutions performed in 1.991 s
 #&gt; 
 #&gt; Error model:
 #&gt; Variance unique to each observed variable 
@@ -691,27 +702,41 @@ Per default, parameters in the kinetic models are internally transformed in
 #&gt; m1_0     0 state
 #&gt; 
 #&gt; Optimised, transformed parameters with symmetric confidence intervals:
-#&gt;                Estimate Std. Error Lower Upper
-#&gt; parent_0       99.65000         NA    NA    NA
-#&gt; log_k_parent   -2.31300         NA    NA    NA
-#&gt; log_k_m1       -5.25000         NA    NA    NA
-#&gt; f_parent_ilr_1  0.03861         NA    NA    NA
-#&gt; sigma_parent    3.40100         NA    NA    NA
-#&gt; sigma_m1        2.85500         NA    NA    NA
+#&gt;                Estimate Std. Error    Lower    Upper
+#&gt; parent_0       99.65000    1.70200 96.19000 103.1000
+#&gt; log_k_parent   -2.31300    0.04376 -2.40200  -2.2240
+#&gt; log_k_m1       -5.25000    0.12430 -5.50400  -4.9970
+#&gt; f_parent_ilr_1  0.03861    0.06171 -0.08708   0.1643
+#&gt; sigma_parent    3.40100    0.56820  2.24400   4.5590
+#&gt; sigma_m1        2.85500    0.45240  1.93400   3.7770
 #&gt; 
 #&gt; Parameter correlation:
-#&gt; No covariance matrix
+#&gt;                parent_0 log_k_parent log_k_m1 f_parent_ilr_1 sigma_parent
+#&gt; parent_0        1.00000      0.51078 -0.19133       -0.59997     0.035670
+#&gt; log_k_parent    0.51078      1.00000 -0.37458       -0.59239     0.069833
+#&gt; log_k_m1       -0.19133     -0.37458  1.00000        0.74398    -0.026158
+#&gt; f_parent_ilr_1 -0.59997     -0.59239  0.74398        1.00000    -0.041368
+#&gt; sigma_parent    0.03567      0.06983 -0.02616       -0.04137     1.000000
+#&gt; sigma_m1       -0.03385     -0.06627  0.02482        0.03925    -0.004628
+#&gt;                 sigma_m1
+#&gt; parent_0       -0.033847
+#&gt; log_k_parent   -0.066265
+#&gt; log_k_m1        0.024821
+#&gt; f_parent_ilr_1  0.039255
+#&gt; sigma_parent   -0.004628
+#&gt; sigma_m1        1.000000
+#&gt; 
 #&gt; Backtransformed parameters:
 #&gt; Confidence intervals for internally transformed parameters are asymmetric.
 #&gt; t-test (unrealistically) based on the assumption of normal distribution
 #&gt; for estimators of untransformed parameters.
-#&gt;                 Estimate t value Pr(&gt;t) Lower Upper
-#&gt; parent_0       99.650000      NA     NA    NA    NA
-#&gt; k_parent        0.098970      NA     NA    NA    NA
-#&gt; k_m1            0.005245      NA     NA    NA    NA
-#&gt; f_parent_to_m1  0.513600      NA     NA    NA    NA
-#&gt; sigma_parent    3.401000      NA     NA    NA    NA
-#&gt; sigma_m1        2.855000      NA     NA    NA    NA
+#&gt;                 Estimate t value    Pr(&gt;t)     Lower     Upper
+#&gt; parent_0       99.650000  58.560 2.004e-34 96.190000 1.031e+02
+#&gt; k_parent        0.098970  22.850 1.099e-21  0.090530 1.082e-01
+#&gt; k_m1            0.005245   8.046 1.732e-09  0.004072 6.756e-03
+#&gt; f_parent_to_m1  0.513600  23.560 4.352e-22  0.469300 5.578e-01
+#&gt; sigma_parent    3.401000   5.985 5.662e-07  2.244000 4.559e+00
+#&gt; sigma_m1        2.855000   6.311 2.215e-07  1.934000 3.777e+00
 #&gt; 
 #&gt; FOCUS Chi2 error levels in percent:
 #&gt;          err.min n.optim df
@@ -768,10 +793,10 @@ Per default, parameters in the kinetic models are internally transformed in
 #&gt;   100       m1    31.04  31.98774 -9.477e-01
 #&gt;   100       m1    33.13  31.98774  1.142e+00
 #&gt;   120       m1    25.15  28.80430 -3.654e+00
-#&gt;   120       m1    33.31  28.80430  4.506e+00</div><div class='input'><span class='no'>f.tc</span> <span class='kw'>&lt;-</span> <span class='fu'>mkinfit</span>(<span class='no'>SFO_SFO.ff</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>error_model</span> <span class='kw'>=</span> <span class='st'>"tc"</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>f.tc</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; mkin version used for fitting:    0.9.49.4 
+#&gt;   120       m1    33.31  28.80430  4.506e+00</div><div class='input'><span class='no'>f.tc</span> <span class='kw'>&lt;-</span> <span class='fu'>mkinfit</span>(<span class='no'>SFO_SFO.ff</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>error_model</span> <span class='kw'>=</span> <span class='st'>"tc"</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>f.tc</span>)</div><div class='output co'>#&gt; mkin version used for fitting:    0.9.49.4 
 #&gt; R version used for fitting:       3.6.0 
-#&gt; Date of fit:     Tue May  7 08:08:34 2019 
-#&gt; Date of summary: Tue May  7 08:08:34 2019 
+#&gt; Date of fit:     Tue May  7 08:36:39 2019 
+#&gt; Date of summary: Tue May  7 08:36:39 2019 
 #&gt; 
 #&gt; Equations:
 #&gt; d_parent/dt = - k_parent * parent
@@ -779,7 +804,7 @@ Per default, parameters in the kinetic models are internally transformed in
 #&gt; 
 #&gt; Model predictions using solution type deSolve 
 #&gt; 
-#&gt; Fitted using 489 model solutions performed in 2.013 s
+#&gt; Fitted using 821 model solutions performed in 3.304 s
 #&gt; 
 #&gt; Error model:
 #&gt; Two-component variance function 
@@ -807,27 +832,34 @@ Per default, parameters in the kinetic models are internally transformed in
 #&gt; m1_0     0 state
 #&gt; 
 #&gt; Optimised, transformed parameters with symmetric confidence intervals:
-#&gt;                 Estimate Std. Error Lower Upper
-#&gt; parent_0       100.70000         NA    NA    NA
-#&gt; log_k_parent    -2.29700         NA    NA    NA
-#&gt; log_k_m1        -5.26600         NA    NA    NA
-#&gt; f_parent_ilr_1   0.02374         NA    NA    NA
-#&gt; sigma_low        0.00305         NA    NA    NA
-#&gt; rsd_high         0.07928         NA    NA    NA
+#&gt;                 Estimate Std. Error     Lower     Upper
+#&gt; parent_0       100.70000   2.621000 95.400000 106.10000
+#&gt; log_k_parent    -2.29700   0.008862 -2.315000  -2.27900
+#&gt; log_k_m1        -5.26600   0.091310 -5.452000  -5.08000
+#&gt; f_parent_ilr_1   0.02374   0.055300 -0.088900   0.13640
+#&gt; sigma_low        0.00305   0.004829 -0.006786   0.01289
+#&gt; rsd_high         0.07928   0.009418  0.060100   0.09847
 #&gt; 
 #&gt; Parameter correlation:
-#&gt; No covariance matrix
+#&gt;                parent_0 log_k_parent log_k_m1 f_parent_ilr_1 sigma_low rsd_high
+#&gt; parent_0        1.00000      0.67644 -0.10215       -0.76822   0.14294 -0.08783
+#&gt; log_k_parent    0.67644      1.00000 -0.15102       -0.59491   0.34611 -0.08125
+#&gt; log_k_m1       -0.10215     -0.15102  1.00000        0.51808  -0.05236  0.01240
+#&gt; f_parent_ilr_1 -0.76822     -0.59491  0.51808        1.00000  -0.13900  0.03248
+#&gt; sigma_low       0.14294      0.34611 -0.05236       -0.13900   1.00000 -0.16546
+#&gt; rsd_high       -0.08783     -0.08125  0.01240        0.03248  -0.16546  1.00000
+#&gt; 
 #&gt; Backtransformed parameters:
 #&gt; Confidence intervals for internally transformed parameters are asymmetric.
 #&gt; t-test (unrealistically) based on the assumption of normal distribution
 #&gt; for estimators of untransformed parameters.
-#&gt;                 Estimate t value Pr(&gt;t) Lower Upper
-#&gt; parent_0       1.007e+02      NA     NA    NA    NA
-#&gt; k_parent       1.006e-01      NA     NA    NA    NA
-#&gt; k_m1           5.167e-03      NA     NA    NA    NA
-#&gt; f_parent_to_m1 5.084e-01      NA     NA    NA    NA
-#&gt; sigma_low      3.050e-03      NA     NA    NA    NA
-#&gt; rsd_high       7.928e-02      NA     NA    NA    NA
+#&gt;                 Estimate  t value    Pr(&gt;t)     Lower     Upper
+#&gt; parent_0       1.007e+02  38.4300 1.180e-28 95.400000 1.061e+02
+#&gt; k_parent       1.006e-01 112.8000 1.718e-43  0.098760 1.024e-01
+#&gt; k_m1           5.167e-03  10.9500 1.172e-12  0.004290 6.223e-03
+#&gt; f_parent_to_m1 5.084e-01  26.0100 2.146e-23  0.468600 5.481e-01
+#&gt; sigma_low      3.050e-03   0.6314 2.661e-01 -0.006786 1.289e-02
+#&gt; rsd_high       7.928e-02   8.4170 6.418e-10  0.060100 9.847e-02
 #&gt; 
 #&gt; FOCUS Chi2 error levels in percent:
 #&gt;          err.min n.optim df
diff --git a/docs/reference/mkinmod.html b/docs/reference/mkinmod.html
index 9f417cf3..d0b2a0eb 100644
--- a/docs/reference/mkinmod.html
+++ b/docs/reference/mkinmod.html
@@ -234,7 +234,7 @@ For the definition of model types and their parameters, the equations given
 <span class='no'>SFO_SFO</span> <span class='kw'>&lt;-</span> <span class='fu'>mkinmod</span>(
   <span class='kw'>parent</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>, <span class='st'>"m1"</span>),
   <span class='kw'>m1</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>), <span class='kw'>verbose</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; Compilation argument:
-#&gt;  /usr/lib/R/bin/R CMD SHLIB file6d1314eef3d7.c 2&gt; file6d1314eef3d7.c.err.txt 
+#&gt;  /usr/lib/R/bin/R CMD SHLIB fileb5a1e31297a.c 2&gt; fileb5a1e31297a.c.err.txt 
 #&gt; Program source:
 #&gt;   1: #include &lt;R.h&gt;
 #&gt;   2: 
diff --git a/docs/reference/mkinparplot-1.png b/docs/reference/mkinparplot-1.png
index d4e465d4..65918d53 100644
Binary files a/docs/reference/mkinparplot-1.png and b/docs/reference/mkinparplot-1.png differ
diff --git a/docs/reference/mkinparplot.html b/docs/reference/mkinparplot.html
index 05af0f15..8cfb9374 100644
--- a/docs/reference/mkinparplot.html
+++ b/docs/reference/mkinparplot.html
@@ -154,7 +154,7 @@
     <pre class="examples"><div class='input'><span class='no'>model</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(
   <span class='kw'>T245</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"phenol"</span>), <span class='kw'>sink</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>),
   <span class='kw'>phenol</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"anisole"</span>)),
-  <span class='kw'>anisole</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>), <span class='kw'>use_of_ff</span> <span class='kw'>=</span> <span class='st'>"max"</span>)</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'><span class='no'>fit</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>model</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/subset'>subset</a></span>(<span class='no'>mccall81_245T</span>, <span class='no'>soil</span> <span class='kw'>==</span> <span class='st'>"Commerce"</span>), <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'>mkinparplot</span>(<span class='no'>fit</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='img'><img src='mkinparplot-1.png' alt='' width='700' height='433' /></div></pre>
+  <span class='kw'>anisole</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>), <span class='kw'>use_of_ff</span> <span class='kw'>=</span> <span class='st'>"max"</span>)</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'><span class='no'>fit</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>model</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/subset'>subset</a></span>(<span class='no'>mccall81_245T</span>, <span class='no'>soil</span> <span class='kw'>==</span> <span class='st'>"Commerce"</span>), <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'>mkinparplot</span>(<span class='no'>fit</span>)</div><div class='img'><img src='mkinparplot-1.png' alt='' width='700' height='433' /></div></pre>
   </div>
   <div class="col-md-3 hidden-xs hidden-sm" id="sidebar">
     <h2>Contents</h2>
diff --git a/docs/reference/mkinpredict.html b/docs/reference/mkinpredict.html
index 8c5c50e4..522cbbfe 100644
--- a/docs/reference/mkinpredict.html
+++ b/docs/reference/mkinpredict.html
@@ -328,12 +328,12 @@
                 <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='kw'>parent</span> <span class='kw'>=</span> <span class='fl'>100</span>, <span class='kw'>m1</span> <span class='kw'>=</span> <span class='fl'>0</span>), <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/seq'>seq</a></span>(<span class='fl'>0</span>, <span class='fl'>20</span>, <span class='kw'>by</span> <span class='kw'>=</span> <span class='fl'>0.1</span>),
                 <span class='kw'>solution_type</span> <span class='kw'>=</span> <span class='st'>"eigen"</span>)[<span class='fl'>201</span>,]))</div><div class='output co'>#&gt;     time   parent       m1
 #&gt; 201   20 4.978707 27.46227</div><div class='output co'>#&gt;        User      System verstrichen 
-#&gt;       0.003       0.000       0.004 </div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/system.time'>system.time</a></span>(
+#&gt;       0.003       0.000       0.003 </div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/system.time'>system.time</a></span>(
     <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='fu'>mkinpredict</span>(<span class='no'>SFO_SFO</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='kw'>k_parent_m1</span> <span class='kw'>=</span> <span class='fl'>0.05</span>, <span class='kw'>k_parent_sink</span> <span class='kw'>=</span> <span class='fl'>0.1</span>, <span class='kw'>k_m1_sink</span> <span class='kw'>=</span> <span class='fl'>0.01</span>),
                 <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='kw'>parent</span> <span class='kw'>=</span> <span class='fl'>100</span>, <span class='kw'>m1</span> <span class='kw'>=</span> <span class='fl'>0</span>), <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/seq'>seq</a></span>(<span class='fl'>0</span>, <span class='fl'>20</span>, <span class='kw'>by</span> <span class='kw'>=</span> <span class='fl'>0.1</span>),
                 <span class='kw'>solution_type</span> <span class='kw'>=</span> <span class='st'>"deSolve"</span>)[<span class='fl'>201</span>,]))</div><div class='output co'>#&gt;     time   parent       m1
 #&gt; 201   20 4.978707 27.46227</div><div class='output co'>#&gt;        User      System verstrichen 
-#&gt;       0.001       0.000       0.001 </div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/system.time'>system.time</a></span>(
+#&gt;       0.001       0.000       0.002 </div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/system.time'>system.time</a></span>(
     <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='fu'>mkinpredict</span>(<span class='no'>SFO_SFO</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='kw'>k_parent_m1</span> <span class='kw'>=</span> <span class='fl'>0.05</span>, <span class='kw'>k_parent_sink</span> <span class='kw'>=</span> <span class='fl'>0.1</span>, <span class='kw'>k_m1_sink</span> <span class='kw'>=</span> <span class='fl'>0.01</span>),
                 <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='kw'>parent</span> <span class='kw'>=</span> <span class='fl'>100</span>, <span class='kw'>m1</span> <span class='kw'>=</span> <span class='fl'>0</span>), <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/seq'>seq</a></span>(<span class='fl'>0</span>, <span class='fl'>20</span>, <span class='kw'>by</span> <span class='kw'>=</span> <span class='fl'>0.1</span>),
                 <span class='kw'>solution_type</span> <span class='kw'>=</span> <span class='st'>"deSolve"</span>, <span class='kw'>use_compiled</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>)[<span class='fl'>201</span>,]))</div><div class='output co'>#&gt;     time   parent       m1
diff --git a/docs/reference/mmkin.html b/docs/reference/mmkin.html
index 849e619e..d0cd748c 100644
--- a/docs/reference/mmkin.html
+++ b/docs/reference/mmkin.html
@@ -194,8 +194,8 @@
 <span class='no'>time_1</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/system.time'>system.time</a></span>(<span class='no'>fits.4</span> <span class='kw'>&lt;-</span> <span class='fu'>mmkin</span>(<span class='no'>models</span>, <span class='no'>datasets</span>, <span class='kw'>cores</span> <span class='kw'>=</span> <span class='fl'>1</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>))
 
 <span class='no'>time_default</span></div><div class='output co'>#&gt;        User      System verstrichen 
-#&gt;       0.039       0.031       3.113 </div><div class='input'><span class='no'>time_1</span></div><div class='output co'>#&gt;        User      System verstrichen 
-#&gt;      10.445       0.001      10.456 </div><div class='input'>
+#&gt;       0.047       0.033       5.463 </div><div class='input'><span class='no'>time_1</span></div><div class='output co'>#&gt;        User      System verstrichen 
+#&gt;      19.909       0.004      19.967 </div><div class='input'>
 <span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>fits.0</span><span class='kw'>[[</span><span class='st'>"SFO_lin"</span>, <span class='fl'>2</span>]])</div><div class='output co'>#&gt; $ff
 #&gt;   parent_M1 parent_sink       M1_M2     M1_sink 
 #&gt;   0.7340481   0.2659519   0.7505684   0.2494316 
diff --git a/docs/reference/nafta.html b/docs/reference/nafta.html
index 62027fab..a9ee2f76 100644
--- a/docs/reference/nafta.html
+++ b/docs/reference/nafta.html
@@ -182,7 +182,7 @@
     
 
     <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>  <span class='no'>nafta_evaluation</span> <span class='kw'>&lt;-</span> <span class='fu'>nafta</span>(<span class='no'>NAFTA_SOP_Appendix_D</span>, <span class='kw'>cores</span> <span class='kw'>=</span> <span class='fl'>1</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; <span class='message'>The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></div><div class='output co'>#&gt; <span class='message'>The representative half-life of the IORE model is longer than the one corresponding</span></div><div class='output co'>#&gt; <span class='message'>to the terminal degradation rate found with the DFOP model.</span></div><div class='output co'>#&gt; <span class='message'>The representative half-life obtained from the DFOP model may be used</span></div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>nafta_evaluation</span>)</div><div class='output co'>#&gt; Sums of squares:
+    <pre class="examples"><div class='input'>  <span class='no'>nafta_evaluation</span> <span class='kw'>&lt;-</span> <span class='fu'>nafta</span>(<span class='no'>NAFTA_SOP_Appendix_D</span>, <span class='kw'>cores</span> <span class='kw'>=</span> <span class='fl'>1</span>)</div><div class='output co'>#&gt; <span class='message'>The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></div><div class='output co'>#&gt; <span class='message'>The representative half-life of the IORE model is longer than the one corresponding</span></div><div class='output co'>#&gt; <span class='message'>to the terminal degradation rate found with the DFOP model.</span></div><div class='output co'>#&gt; <span class='message'>The representative half-life obtained from the DFOP model may be used</span></div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>nafta_evaluation</span>)</div><div class='output co'>#&gt; Sums of squares:
 #&gt;       SFO      IORE      DFOP 
 #&gt; 1378.6832  615.7730  517.8836 
 #&gt; 
@@ -191,25 +191,25 @@
 #&gt; 
 #&gt; Parameters:
 #&gt; $SFO
-#&gt;               Estimate Pr(&gt;t) Lower Upper
-#&gt; parent_0       83.7558     NA    NA    NA
-#&gt; k_parent_sink   0.0017     NA    NA    NA
-#&gt; sigma           8.7518     NA    NA    NA
+#&gt;               Estimate   Pr(&gt;t)    Lower   Upper
+#&gt; parent_0       83.7558 1.80e-14 77.18268 90.3288
+#&gt; k_parent_sink   0.0017 7.43e-05  0.00112  0.0026
+#&gt; sigma           8.7518 1.22e-05  5.64278 11.8608
 #&gt; 
 #&gt; $IORE
-#&gt;                     Estimate Pr(&gt;t) Lower Upper
-#&gt; parent_0            9.69e+01     NA    NA    NA
-#&gt; k__iore_parent_sink 8.40e-14     NA    NA    NA
-#&gt; N_parent            6.68e+00     NA    NA    NA
-#&gt; sigma               5.85e+00     NA    NA    NA
+#&gt;                     Estimate Pr(&gt;t)    Lower    Upper
+#&gt; parent_0            9.69e+01     NA 8.88e+01 1.05e+02
+#&gt; k__iore_parent_sink 8.40e-14     NA 1.79e-18 3.94e-09
+#&gt; N_parent            6.68e+00     NA 4.19e+00 9.17e+00
+#&gt; sigma               5.85e+00     NA 3.76e+00 7.94e+00
 #&gt; 
 #&gt; $DFOP
-#&gt;          Estimate Pr(&gt;t) Lower Upper
-#&gt; parent_0 9.76e+01     NA    NA    NA
-#&gt; k1       4.24e-02     NA    NA    NA
-#&gt; k2       8.24e-04     NA    NA    NA
-#&gt; g        2.88e-01     NA    NA    NA
-#&gt; sigma    5.36e+00     NA    NA    NA
+#&gt;          Estimate   Pr(&gt;t)    Lower    Upper
+#&gt; parent_0 9.76e+01 1.94e-13 9.02e+01 1.05e+02
+#&gt; k1       4.24e-02 5.92e-03 2.03e-02 8.88e-02
+#&gt; k2       8.24e-04 6.48e-03 3.89e-04 1.75e-03
+#&gt; g        2.88e-01 2.47e-05 1.95e-01 4.03e-01
+#&gt; sigma    5.36e+00 2.22e-05 3.43e+00 7.30e+00
 #&gt; 
 #&gt; 
 #&gt; DTx values:
diff --git a/docs/reference/summary.mkinfit.html b/docs/reference/summary.mkinfit.html
index a4f3d04f..9c4a21a9 100644
--- a/docs/reference/summary.mkinfit.html
+++ b/docs/reference/summary.mkinfit.html
@@ -209,17 +209,17 @@
     
 
     <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(<span class='kw'>parent</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>)), <span class='no'>FOCUS_2006_A</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>))</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt; mkin version used for fitting:    0.9.49.4 
+    <pre class="examples"><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(<span class='kw'>parent</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>)), <span class='no'>FOCUS_2006_A</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>))</div><div class='output co'>#&gt; mkin version used for fitting:    0.9.49.4 
 #&gt; R version used for fitting:       3.6.0 
-#&gt; Date of fit:     Tue May  7 08:09:03 2019 
-#&gt; Date of summary: Tue May  7 08:09:03 2019 
+#&gt; Date of fit:     Tue May  7 08:37:31 2019 
+#&gt; Date of summary: Tue May  7 08:37:31 2019 
 #&gt; 
 #&gt; Equations:
 #&gt; d_parent/dt = - k_parent_sink * parent
 #&gt; 
 #&gt; Model predictions using solution type analytical 
 #&gt; 
-#&gt; Fitted using 39 model solutions performed in 0.08 s
+#&gt; Fitted using 131 model solutions performed in 0.277 s
 #&gt; 
 #&gt; Error model:
 #&gt; Constant variance 
@@ -240,21 +240,25 @@
 #&gt; None
 #&gt; 
 #&gt; Optimised, transformed parameters with symmetric confidence intervals:
-#&gt;                   Estimate Std. Error Lower Upper
-#&gt; parent_0           109.200         NA    NA    NA
-#&gt; log_k_parent_sink   -3.291         NA    NA    NA
-#&gt; sigma                5.266         NA    NA    NA
+#&gt;                   Estimate Std. Error  Lower   Upper
+#&gt; parent_0           109.200    3.70400 99.630 118.700
+#&gt; log_k_parent_sink   -3.291    0.09176 -3.527  -3.055
+#&gt; sigma                5.266    1.31600  1.882   8.649
 #&gt; 
 #&gt; Parameter correlation:
-#&gt; No covariance matrix
+#&gt;                    parent_0 log_k_parent_sink     sigma
+#&gt; parent_0          1.000e+00         5.428e-01 1.648e-07
+#&gt; log_k_parent_sink 5.428e-01         1.000e+00 2.513e-07
+#&gt; sigma             1.648e-07         2.513e-07 1.000e+00
+#&gt; 
 #&gt; Backtransformed parameters:
 #&gt; Confidence intervals for internally transformed parameters are asymmetric.
 #&gt; t-test (unrealistically) based on the assumption of normal distribution
 #&gt; for estimators of untransformed parameters.
-#&gt;                Estimate t value Pr(&gt;t) Lower Upper
-#&gt; parent_0      109.20000      NA     NA    NA    NA
-#&gt; k_parent_sink   0.03722      NA     NA    NA    NA
-#&gt; sigma           5.26600      NA     NA    NA    NA
+#&gt;                Estimate t value    Pr(&gt;t)   Lower     Upper
+#&gt; parent_0      109.20000   29.47 4.218e-07 99.6300 118.70000
+#&gt; k_parent_sink   0.03722   10.90 5.650e-05  0.0294   0.04712
+#&gt; sigma           5.26600    4.00 5.162e-03  1.8820   8.64900
 #&gt; 
 #&gt; FOCUS Chi2 error levels in percent:
 #&gt;          err.min n.optim df
diff --git a/docs/reference/test_data_from_UBA_2014.html b/docs/reference/test_data_from_UBA_2014.html
index 11cb6420..bc988340 100644
--- a/docs/reference/test_data_from_UBA_2014.html
+++ b/docs/reference/test_data_from_UBA_2014.html
@@ -159,13 +159,20 @@
   <span class='co'># model).</span>
   <span class='no'>m_ws</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(<span class='kw'>parent_w</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>, <span class='st'>"parent_s"</span>),
                   <span class='kw'>parent_s</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>, <span class='st'>"parent_w"</span>))</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'>  <span class='no'>f_river</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>m_ws</span>, <span class='no'>test_data_from_UBA_2014</span><span class='kw'>[[</span><span class='fl'>1</span>]]$<span class='no'>data</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'>  <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span>(<span class='no'>f_river</span>)</div><div class='img'><img src='test_data_from_UBA_2014-1.png' alt='' width='700' height='433' /></div><div class='input'>
-  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>f_river</span>)$<span class='no'>bpar</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt;                         Estimate se_notrans t value Pr(&gt;t) Lower Upper
-#&gt; parent_w_0          9.598567e+01         NA      NA     NA    NA    NA
-#&gt; k_parent_w_sink     3.603743e-01         NA      NA     NA    NA    NA
-#&gt; k_parent_w_parent_s 6.031371e-02         NA      NA     NA    NA    NA
-#&gt; k_parent_s_sink     5.108964e-11         NA      NA     NA    NA    NA
-#&gt; k_parent_s_parent_w 7.419672e-02         NA      NA     NA    NA    NA
-#&gt; sigma               2.982879e+00         NA      NA     NA    NA    NA</div><div class='input'>  <span class='fu'><a href='mkinerrmin.html'>mkinerrmin</a></span>(<span class='no'>f_river</span>)</div><div class='output co'>#&gt;             err.min n.optim df
+  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>f_river</span>)$<span class='no'>bpar</span></div><div class='output co'>#&gt;                         Estimate se_notrans      t value       Pr(&gt;t)
+#&gt; parent_w_0          9.598567e+01 2.12351789 4.520126e+01 9.476190e-18
+#&gt; k_parent_w_sink     3.603743e-01 0.03149282 1.144306e+01 4.126593e-09
+#&gt; k_parent_w_parent_s 6.031371e-02 0.01603582 3.761186e+00 9.436275e-04
+#&gt; k_parent_s_sink     5.108964e-11 0.09482736 5.387647e-10 5.000000e-01
+#&gt; k_parent_s_parent_w 7.419672e-02 0.10737376 6.910135e-01 2.500560e-01
+#&gt; sigma               2.982879e+00 0.50545649 5.901356e+00 1.454535e-05
+#&gt;                           Lower       Upper
+#&gt; parent_w_0          91.48420503 100.4871438
+#&gt; k_parent_w_sink      0.30668904   0.4234571
+#&gt; k_parent_w_parent_s  0.03423904   0.1062455
+#&gt; k_parent_s_sink      0.00000000         Inf
+#&gt; k_parent_s_parent_w  0.02289956   0.2404043
+#&gt; sigma                2.00184022   3.9639169</div><div class='input'>  <span class='fu'><a href='mkinerrmin.html'>mkinerrmin</a></span>(<span class='no'>f_river</span>)</div><div class='output co'>#&gt;             err.min n.optim df
 #&gt; All data 0.09246946       5  6
 #&gt; parent_w 0.06377096       3  3
 #&gt; parent_s 0.20882325       2  3</div><div class='input'>
@@ -176,17 +183,28 @@
                     <span class='kw'>M2</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>, <span class='st'>"M3"</span>),
                     <span class='kw'>M3</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>),
                     <span class='kw'>use_of_ff</span> <span class='kw'>=</span> <span class='st'>"max"</span>)</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'>
-  <span class='no'>f_soil</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>m_soil</span>, <span class='no'>test_data_from_UBA_2014</span><span class='kw'>[[</span><span class='fl'>3</span>]]$<span class='no'>data</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'>  <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span>(<span class='no'>f_soil</span>, <span class='kw'>lpos</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"topright"</span>, <span class='st'>"topright"</span>, <span class='st'>"topright"</span>, <span class='st'>"bottomright"</span>))</div><div class='img'><img src='test_data_from_UBA_2014-2.png' alt='' width='700' height='433' /></div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>f_soil</span>)$<span class='no'>bpar</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#&gt;                   Estimate se_notrans t value Pr(&gt;t) Lower Upper
-#&gt; parent_0       76.55425584         NA      NA     NA    NA    NA
-#&gt; k_parent        0.12081956         NA      NA     NA    NA    NA
-#&gt; k_M1            0.84258649         NA      NA     NA    NA    NA
-#&gt; k_M2            0.04210878         NA      NA     NA    NA    NA
-#&gt; k_M3            0.01122919         NA      NA     NA    NA    NA
-#&gt; f_parent_to_M1  0.32240199         NA      NA     NA    NA    NA
-#&gt; f_parent_to_M2  0.16099854         NA      NA     NA    NA    NA
-#&gt; f_M1_to_M3      0.27921501         NA      NA     NA    NA    NA
-#&gt; f_M2_to_M3      0.55641331         NA      NA     NA    NA    NA
-#&gt; sigma           1.14005399         NA      NA     NA    NA    NA</div><div class='input'>  <span class='fu'><a href='mkinerrmin.html'>mkinerrmin</a></span>(<span class='no'>f_soil</span>)</div><div class='output co'>#&gt;             err.min n.optim df
+  <span class='no'>f_soil</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>m_soil</span>, <span class='no'>test_data_from_UBA_2014</span><span class='kw'>[[</span><span class='fl'>3</span>]]$<span class='no'>data</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'>  <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span>(<span class='no'>f_soil</span>, <span class='kw'>lpos</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"topright"</span>, <span class='st'>"topright"</span>, <span class='st'>"topright"</span>, <span class='st'>"bottomright"</span>))</div><div class='img'><img src='test_data_from_UBA_2014-2.png' alt='' width='700' height='433' /></div><div class='input'>  <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>f_soil</span>)$<span class='no'>bpar</span></div><div class='output co'>#&gt;                   Estimate  se_notrans    t value       Pr(&gt;t)        Lower
+#&gt; parent_0       76.55425584 0.859186619 89.1008474 1.113866e-26 74.755959756
+#&gt; k_parent        0.12081956 0.004601922 26.2541544 1.077373e-16  0.111561582
+#&gt; k_M1            0.84258649 0.806231419  1.0450926 1.545475e-01  0.113839803
+#&gt; k_M2            0.04210878 0.017083049  2.4649453 1.170195e-02  0.018013807
+#&gt; k_M3            0.01122919 0.007245890  1.5497322 6.885127e-02  0.002909463
+#&gt; f_parent_to_M1  0.32240199 0.240803555  1.3388589 9.820820e-02           NA
+#&gt; f_parent_to_M2  0.16099854 0.033691991  4.7785403 6.531224e-05           NA
+#&gt; f_M1_to_M3      0.27921501 0.269443514  1.0362655 1.565440e-01  0.022992937
+#&gt; f_M2_to_M3      0.55641331 0.595125445  0.9349513 1.807725e-01  0.008003317
+#&gt; sigma           1.14005399 0.149696423  7.6157731 1.727024e-07  0.826735778
+#&gt;                      Upper
+#&gt; parent_0       78.35255192
+#&gt; k_parent        0.13084582
+#&gt; k_M1            6.23641265
+#&gt; k_M2            0.09843279
+#&gt; k_M3            0.04333950
+#&gt; f_parent_to_M1          NA
+#&gt; f_parent_to_M2          NA
+#&gt; f_M1_to_M3      0.86443083
+#&gt; f_M2_to_M3      0.99489847
+#&gt; sigma           1.45337221</div><div class='input'>  <span class='fu'><a href='mkinerrmin.html'>mkinerrmin</a></span>(<span class='no'>f_soil</span>)</div><div class='output co'>#&gt;             err.min n.optim df
 #&gt; All data 0.09649963       9 20
 #&gt; parent   0.04721283       2  6
 #&gt; M1       0.26551209       2  5
diff --git a/docs/reference/transform_odeparms.html b/docs/reference/transform_odeparms.html
index c91565b9..7e05480e 100644
--- a/docs/reference/transform_odeparms.html
+++ b/docs/reference/transform_odeparms.html
@@ -202,30 +202,32 @@ The transformation of sets of formation fractions is fragile, as it supposes
     <pre class="examples"><div class='input'><span class='no'>SFO_SFO</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(
   <span class='kw'>parent</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/list'>list</a></span>(<span class='kw'>type</span> <span class='kw'>=</span> <span class='st'>"SFO"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"m1"</span>, <span class='kw'>sink</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>),
   <span class='kw'>m1</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/list'>list</a></span>(<span class='kw'>type</span> <span class='kw'>=</span> <span class='st'>"SFO"</span>))</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'><span class='co'># Fit the model to the FOCUS example dataset D using defaults</span>
-<span class='no'>fit</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='no'>fit.s</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='input'><span class='co'># Transformed and backtransformed parameters</span>
-<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.s</span>$<span class='no'>par</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;                   Estimate Std. Error Lower Upper
-#&gt; parent_0             99.60         NA    NA    NA
-#&gt; log_k_parent_sink    -3.04         NA    NA    NA
-#&gt; log_k_parent_m1      -2.98         NA    NA    NA
-#&gt; log_k_m1_sink        -5.25         NA    NA    NA
-#&gt; sigma                 3.13         NA    NA    NA</div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.s</span>$<span class='no'>bpar</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;               Estimate se_notrans t value Pr(&gt;t) Lower Upper
-#&gt; parent_0      99.59848         NA      NA     NA    NA    NA
-#&gt; k_parent_sink  0.04792         NA      NA     NA    NA    NA
-#&gt; k_parent_m1    0.05078         NA      NA     NA    NA    NA
-#&gt; k_m1_sink      0.00526         NA      NA     NA    NA    NA
-#&gt; sigma          3.12550         NA      NA     NA    NA    NA</div><div class='input'>
+<span class='no'>fit</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='no'>fit.s</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit</span>)
+<span class='co'># Transformed and backtransformed parameters</span>
+<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.s</span>$<span class='no'>par</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;                   Estimate Std. Error Lower  Upper
+#&gt; parent_0             99.60     1.5702 96.40 102.79
+#&gt; log_k_parent_sink    -3.04     0.0763 -3.19  -2.88
+#&gt; log_k_parent_m1      -2.98     0.0403 -3.06  -2.90
+#&gt; log_k_m1_sink        -5.25     0.1332 -5.52  -4.98
+#&gt; sigma                 3.13     0.3585  2.40   3.85</div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.s</span>$<span class='no'>bpar</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;               Estimate se_notrans t value   Pr(&gt;t)    Lower    Upper
+#&gt; parent_0      99.59848    1.57022   63.43 2.30e-36 96.40384 102.7931
+#&gt; k_parent_sink  0.04792    0.00365   13.11 6.13e-15  0.04103   0.0560
+#&gt; k_parent_m1    0.05078    0.00205   24.80 3.27e-23  0.04678   0.0551
+#&gt; k_m1_sink      0.00526    0.00070    7.51 6.16e-09  0.00401   0.0069
+#&gt; sigma          3.12550    0.35852    8.72 2.24e-10  2.39609   3.8549</div><div class='input'>
 </div><div class='input'><span class='co'># Compare to the version without transforming rate parameters</span>
-<span class='no'>fit.2</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>transform_rates</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='no'>fit.2.s</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit.2</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.2.s</span>$<span class='no'>par</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;               Estimate Std. Error Lower Upper
-#&gt; parent_0      99.59848         NA    NA    NA
-#&gt; k_parent_sink  0.04792         NA    NA    NA
-#&gt; k_parent_m1    0.05078         NA    NA    NA
-#&gt; k_m1_sink      0.00526         NA    NA    NA
-#&gt; sigma          3.12550         NA    NA    NA</div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.2.s</span>$<span class='no'>bpar</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;               Estimate se_notrans t value Pr(&gt;t) Lower Upper
-#&gt; parent_0      99.59848         NA      NA     NA    NA    NA
-#&gt; k_parent_sink  0.04792         NA      NA     NA    NA    NA
-#&gt; k_parent_m1    0.05078         NA      NA     NA    NA    NA
-#&gt; k_m1_sink      0.00526         NA      NA     NA    NA    NA
-#&gt; sigma          3.12550         NA      NA     NA    NA    NA</div><div class='input'>
+<span class='no'>fit.2</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>transform_rates</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='no'>fit.2.s</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit.2</span>)
+<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.2.s</span>$<span class='no'>par</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;               Estimate Std. Error    Lower    Upper
+#&gt; parent_0      99.59848    1.57022 96.40384 1.03e+02
+#&gt; k_parent_sink  0.04792    0.00365  0.04049 5.54e-02
+#&gt; k_parent_m1    0.05078    0.00205  0.04661 5.49e-02
+#&gt; k_m1_sink      0.00526    0.00070  0.00384 6.69e-03
+#&gt; sigma          3.12550    0.35852  2.39609 3.85e+00</div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.2.s</span>$<span class='no'>bpar</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;               Estimate se_notrans t value   Pr(&gt;t)    Lower    Upper
+#&gt; parent_0      99.59848    1.57022   63.43 2.30e-36 96.40384 1.03e+02
+#&gt; k_parent_sink  0.04792    0.00365   13.11 6.13e-15  0.04049 5.54e-02
+#&gt; k_parent_m1    0.05078    0.00205   24.80 3.27e-23  0.04661 5.49e-02
+#&gt; k_m1_sink      0.00526    0.00070    7.51 6.16e-09  0.00384 6.69e-03
+#&gt; sigma          3.12550    0.35852    8.72 2.24e-10  2.39609 3.85e+00</div><div class='input'>
 <span class='no'>initials</span> <span class='kw'>&lt;-</span> <span class='no'>fit</span>$<span class='no'>start</span>$<span class='no'>value</span>
 <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/names'>names</a></span>(<span class='no'>initials</span>) <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/colnames'>rownames</a></span>(<span class='no'>fit</span>$<span class='no'>start</span>)
 <span class='no'>transformed</span> <span class='kw'>&lt;-</span> <span class='no'>fit</span>$<span class='no'>start_transformed</span>$<span class='no'>value</span>
@@ -238,17 +240,18 @@ The transformation of sets of formation fractions is fragile, as it supposes
   <span class='kw'>parent</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/list'>list</a></span>(<span class='kw'>type</span> <span class='kw'>=</span> <span class='st'>"SFO"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"m1"</span>, <span class='kw'>sink</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>),
   <span class='kw'>m1</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/list'>list</a></span>(<span class='kw'>type</span> <span class='kw'>=</span> <span class='st'>"SFO"</span>),
   <span class='kw'>use_of_ff</span> <span class='kw'>=</span> <span class='st'>"max"</span>)</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'>
-<span class='no'>fit.ff</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO.ff</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='no'>fit.ff.s</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit.ff</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.ff.s</span>$<span class='no'>par</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;                Estimate Std. Error Lower Upper
-#&gt; parent_0         99.598         NA    NA    NA
-#&gt; log_k_parent     -2.316         NA    NA    NA
-#&gt; log_k_m1         -5.248         NA    NA    NA
-#&gt; f_parent_ilr_1    0.041         NA    NA    NA
-#&gt; sigma             3.126         NA    NA    NA</div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.ff.s</span>$<span class='no'>bpar</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;                Estimate se_notrans t value Pr(&gt;t) Lower Upper
-#&gt; parent_0       99.59848         NA      NA     NA    NA    NA
-#&gt; k_parent        0.09870         NA      NA     NA    NA    NA
-#&gt; k_m1            0.00526         NA      NA     NA    NA    NA
-#&gt; f_parent_to_m1  0.51448         NA      NA     NA    NA    NA
-#&gt; sigma           3.12550         NA      NA     NA    NA    NA</div><div class='input'><span class='no'>initials</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"f_parent_to_m1"</span> <span class='kw'>=</span> <span class='fl'>0.5</span>)
+<span class='no'>fit.ff</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO.ff</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='no'>fit.ff.s</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit.ff</span>)
+<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.ff.s</span>$<span class='no'>par</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;                Estimate Std. Error   Lower   Upper
+#&gt; parent_0         99.598     1.5702 96.4038 102.793
+#&gt; log_k_parent     -2.316     0.0409 -2.3988  -2.233
+#&gt; log_k_m1         -5.248     0.1332 -5.5184  -4.977
+#&gt; f_parent_ilr_1    0.041     0.0631 -0.0875   0.169
+#&gt; sigma             3.126     0.3585  2.3961   3.855</div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.ff.s</span>$<span class='no'>bpar</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;                Estimate se_notrans t value   Pr(&gt;t)    Lower    Upper
+#&gt; parent_0       99.59848    1.57022   63.43 2.30e-36 96.40384 102.7931
+#&gt; k_parent        0.09870    0.00403   24.47 4.96e-23  0.09082   0.1073
+#&gt; k_m1            0.00526    0.00070    7.51 6.16e-09  0.00401   0.0069
+#&gt; f_parent_to_m1  0.51448    0.02230   23.07 3.10e-22  0.46912   0.5596
+#&gt; sigma           3.12550    0.35852    8.72 2.24e-10  2.39609   3.8549</div><div class='input'><span class='no'>initials</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"f_parent_to_m1"</span> <span class='kw'>=</span> <span class='fl'>0.5</span>)
 <span class='no'>transformed</span> <span class='kw'>&lt;-</span> <span class='fu'>transform_odeparms</span>(<span class='no'>initials</span>, <span class='no'>SFO_SFO.ff</span>)
 <span class='fu'>backtransform_odeparms</span>(<span class='no'>transformed</span>, <span class='no'>SFO_SFO.ff</span>)</div><div class='output co'>#&gt; f_parent_to_m1 
 #&gt;            0.5 </div><div class='input'>
@@ -258,15 +261,16 @@ The transformation of sets of formation fractions is fragile, as it supposes
   <span class='kw'>m1</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/list'>list</a></span>(<span class='kw'>type</span> <span class='kw'>=</span> <span class='st'>"SFO"</span>),
   <span class='kw'>use_of_ff</span> <span class='kw'>=</span> <span class='st'>"max"</span>)</div><div class='output co'>#&gt; <span class='message'>Successfully compiled differential equation model from auto-generated C code.</span></div><div class='input'>
 
-<span class='no'>fit.ff.2</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO.ff.2</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='no'>fit.ff.2.s</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit.ff.2</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.ff.2.s</span>$<span class='no'>par</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;              Estimate Std. Error Lower Upper
-#&gt; parent_0        84.79         NA    NA    NA
-#&gt; log_k_parent    -2.76         NA    NA    NA
-#&gt; log_k_m1        -4.21         NA    NA    NA
-#&gt; sigma            8.22         NA    NA    NA</div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.ff.2.s</span>$<span class='no'>bpar</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;          Estimate se_notrans t value Pr(&gt;t) Lower Upper
-#&gt; parent_0  84.7916         NA      NA     NA    NA    NA
-#&gt; k_parent   0.0635         NA      NA     NA    NA    NA
-#&gt; k_m1       0.0148         NA      NA     NA    NA    NA
-#&gt; sigma      8.2229         NA      NA     NA    NA    NA</div></pre>
+<span class='no'>fit.ff.2</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span>(<span class='no'>SFO_SFO.ff.2</span>, <span class='no'>FOCUS_2006_D</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='no'>fit.ff.2.s</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/summary'>summary</a></span>(<span class='no'>fit.ff.2</span>)
+<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.ff.2.s</span>$<span class='no'>par</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;              Estimate Std. Error Lower Upper
+#&gt; parent_0        84.79      3.012 78.67 90.91
+#&gt; log_k_parent    -2.76      0.082 -2.92 -2.59
+#&gt; log_k_m1        -4.21      0.123 -4.46 -3.96
+#&gt; sigma            8.22      0.943  6.31 10.14</div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>fit.ff.2.s</span>$<span class='no'>bpar</span>, <span class='fl'>3</span>)</div><div class='output co'>#&gt;          Estimate se_notrans t value   Pr(&gt;t)   Lower  Upper
+#&gt; parent_0  84.7916    3.01203   28.15 1.92e-25 78.6704 90.913
+#&gt; k_parent   0.0635    0.00521   12.19 2.91e-14  0.0538  0.075
+#&gt; k_m1       0.0148    0.00182    8.13 8.81e-10  0.0115  0.019
+#&gt; sigma      8.2229    0.94323    8.72 1.73e-10  6.3060 10.140</div></pre>
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     <h2>Contents</h2>
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