From 1718d434efae26de02754c6622c43f4dc9e624b9 Mon Sep 17 00:00:00 2001 From: jranke Date: Thu, 15 Mar 2012 15:54:14 +0000 Subject: Update kinfit and mkin to the latest version published on BerliOS. git-svn-id: svn+ssh://svn.r-forge.r-project.org/svnroot/kinfit/pkg/mkin@17 edb9625f-4e0d-4859-8d74-9fd3b1da38cb --- inst/doc/Rplots.pdf | 23902 ++++++++++++++++++++++++++++++++++++++++++++++ inst/doc/mkin.Rnw | 25 +- inst/doc/mkin.pdf | Bin 176018 -> 178902 bytes inst/doc/references.bib | 7 + 4 files changed, 23929 insertions(+), 5 deletions(-) create mode 100644 inst/doc/Rplots.pdf (limited to 'inst/doc') diff --git a/inst/doc/Rplots.pdf b/inst/doc/Rplots.pdf new file mode 100644 index 00000000..a6ed15eb --- /dev/null +++ b/inst/doc/Rplots.pdf @@ -0,0 +1,23902 @@ +%PDF-1.4 +%ρ\r +1 0 obj +<< +/CreationDate (D:20110311125259) +/ModDate (D:20110311125259) +/Title (R Graphics Output) +/Producer (R 2.12.1) +/Creator (R) +>> +endobj +2 0 obj +<< +/Type /Catalog +/Pages 3 0 R +>> +endobj +5 0 obj 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b/inst/doc/mkin.Rnw @@ -1,3 +1,4 @@ +% $Id: mkin.Rnw 66 2010-09-03 08:50:26Z jranke $ %%\VignetteIndexEntry{Routines for fitting kinetic models with one or more state variables to chemical degradation data} %%VignetteDepends{FME} %%\usepackage{Sweave} @@ -78,7 +79,7 @@ barrier for \RR{} newcomers. \subsection{Data format} The following listing shows example dataset C from the FOCUS kinetics -report as distributed with the \Rpackage{kinfit} package +report as distributed with the \Rpackage{mkin} package <>= library("mkin") @@ -101,8 +102,9 @@ as shown in the following listing <>= example_data <- data.frame( + name = rep("parent", 9), time = c(0, 1, 3, 7, 14, 28, 63, 91, 119), - parent = c(85.1, 57.9, 29.9, 14.6, 9.7, 6.6, 4, 3.9, 0.6) + value = c(85.1, 57.9, 29.9, 14.6, 9.7, 6.6, 4, 3.9, 0.6) ) @ @@ -122,12 +124,23 @@ SFORB_SFO <- mkinmod( m1 = list(type = "SFO")) @ +The model definitions given above define sets of linear first-order ordinary +differential equations. In these cases, a coefficient matrix is also returned. + +Other models that include time on the right-hand side of the differential +equation are the first-order multi-compartment (FOMC) model and the +Hockey-Stick (HS) model. At present, only the FOMC model can only be used, and +only for the parent compound. + \subsection{Fitting the model} Then the model parameters should be fitted to the data. The function \Robject{mkinfit} internally creates a cost function using \Robject{modCost} from the \Rpackage{FME} package and the produces a fit using \Robject{modFit} -from the same package. +from the same package. In cases of linear first-order differential +equations, the solution used for calculating the cost function is based +on the fundamental system of the coefficient matrix, as proposed by +\citet{bates88}. <>= # Do not show significance stars as they interfere with vignette generation @@ -136,8 +149,10 @@ SFO.fit <- mkinfit(SFO, FOCUS_2006_C) summary(SFO.fit) SFORB.fit <- mkinfit(SFORB, FOCUS_2006_C) summary(SFORB.fit) -SFO_SFO.fit <- mkinfit(SFO_SFO, FOCUS_2006_D) -summary(SFO_SFO.fit) +SFO_SFO.fit <- mkinfit(SFO_SFO, FOCUS_2006_D, plot=TRUE) +summary(SFO_SFO.fit, data=FALSE) +SFORB_SFO.fit <- mkinfit(SFORB_SFO, FOCUS_2006_D, plot=TRUE) +summary(SFORB_SFO.fit, data=FALSE) @ \bibliographystyle{plainnat} diff --git a/inst/doc/mkin.pdf b/inst/doc/mkin.pdf index 4d2e1d10..f963d1e6 100644 Binary files a/inst/doc/mkin.pdf and b/inst/doc/mkin.pdf differ diff --git a/inst/doc/references.bib b/inst/doc/references.bib index b158eebf..24672e2e 100644 --- a/inst/doc/references.bib +++ b/inst/doc/references.bib @@ -53,3 +53,10 @@ address = {Piacenza}, pages = {916--923} } + +@Book{ bates88, + title = {Nonlinear regression and its applications}, + author = {D. Bates and D. Watts}, + year = {1988}, + publisher = {Wiley-Interscience} +} -- cgit v1.2.1