From c04d0bb0e795b67b6958150e8524c5265587f618 Mon Sep 17 00:00:00 2001 From: Johannes Ranke Date: Wed, 12 Nov 2014 16:59:48 +0100 Subject: IORE working for parent and metabolites, introduce mkinsub --- man/mkinfit.Rd | 6 ++++++ 1 file changed, 6 insertions(+) (limited to 'man/mkinfit.Rd') diff --git a/man/mkinfit.Rd b/man/mkinfit.Rd index c40dff83..a16ed177 100644 --- a/man/mkinfit.Rd +++ b/man/mkinfit.Rd @@ -216,6 +216,12 @@ mkinfit(mkinmod, observed, Gao). A similar implemention can also be found in CAKE 2.0, which is the other GUI derivative of mkin, sponsored by Syngenta. } +\note{ + When using the "IORE" submodel for metabolites, fitting with + "transform_rates = TRUE" (the default) often leads to failures of the + numerical ODE solver. In this situation it may help to switch off the + internal rate transformation. +} \author{ Johannes Ranke } -- cgit v1.2.1