From 351248d07f810ccb6c497633a02cd48ee35526e6 Mon Sep 17 00:00:00 2001
From: Johannes Ranke <jranke@uni-bremen.de>
Date: Wed, 2 Mar 2022 13:11:49 +0100
Subject: Fix nlmixr fits with parallel metabolites

---
 man/nlmixr.mmkin.Rd | 24 ++++++++++++++++++++++++
 1 file changed, 24 insertions(+)

(limited to 'man')

diff --git a/man/nlmixr.mmkin.Rd b/man/nlmixr.mmkin.Rd
index f9349727..e8a9d170 100644
--- a/man/nlmixr.mmkin.Rd
+++ b/man/nlmixr.mmkin.Rd
@@ -216,6 +216,30 @@ AIC(
 plot(f_nlmixr_fomc_sfo_focei_obs_tc)
 summary(f_nlmixr_fomc_sfo_focei_obs_tc)
 }
+
+# Two parallel metabolites
+dmta_ds <- lapply(1:7, function(i) {
+  ds_i <- dimethenamid_2018$ds[[i]]$data
+  ds_i[ds_i$name == "DMTAP", "name"] <-  "DMTA"
+  ds_i$time <- ds_i$time * dimethenamid_2018$f_time_norm[i]
+  ds_i
+})
+names(dmta_ds) <- sapply(dimethenamid_2018$ds, function(ds) ds$title)
+dmta_ds[["Elliot"]] <- rbind(dmta_ds[["Elliot 1"]], dmta_ds[["Elliot 2"]])
+dmta_ds[["Elliot 1"]] <- NULL
+dmta_ds[["Elliot 2"]] <- NULL
+sfo_sfo2 <- mkinmod(
+  DMTA = mkinsub("SFO", c("M23", "M27")),
+  M23 = mkinsub("SFO"),
+  M27 = mkinsub("SFO"),
+  quiet = TRUE
+)
+f_dmta_sfo_sfo2 <- mmkin(
+  list("SFO-SFO2" = sfo_sfo2),
+  dmta_ds, quiet = TRUE, error_model = "obs")
+nlmixr_model(f_dmta_sfo_sfo2)
+nlmixr_focei_dmta_sfo_sfo2 <- nlmixr(f_dmta_sfo_sfo2, est = "focei")
+
 }
 \seealso{
 \link{summary.nlmixr.mmkin} \link{plot.mixed.mmkin}
-- 
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