From 7035cde3a53781721fe15a8893fdf328c789bdd2 Mon Sep 17 00:00:00 2001 From: Johannes Ranke Date: Mon, 7 Mar 2022 12:03:40 +0100 Subject: Remove nlmixr interface for release of mkin 1.1.0 I am postponing my attempts to get the nlmixr interface to CRAN, given some problems with nlmixr using R-devel under Windows, see https://github.com/nlmixrdevelopment/nlmixr/issues/596 and https://github.com/r-hub/rhub/issues/512, which is fixed by the removal of nlmixr from the testsuite. For the tests to be more platform independent, the biphasic mixed effects models test dataset was defined in a way that fitting should be more robust (less ill-defined). --- tests/testthat/summary_saem_biphasic_s.txt | 40 +++++++++++++++--------------- 1 file changed, 20 insertions(+), 20 deletions(-) (limited to 'tests/testthat/summary_saem_biphasic_s.txt') diff --git a/tests/testthat/summary_saem_biphasic_s.txt b/tests/testthat/summary_saem_biphasic_s.txt index a353d821..6b203991 100644 --- a/tests/testthat/summary_saem_biphasic_s.txt +++ b/tests/testthat/summary_saem_biphasic_s.txt @@ -13,7 +13,7 @@ d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) exp(-k2 * time))) * parent - k_m1 * m1 Data: -507 observations of 2 variable(s) grouped in 15 datasets +510 observations of 2 variable(s) grouped in 15 datasets Model predictions using solution type analytical @@ -24,7 +24,7 @@ Variance model: Two-component variance function Mean of starting values for individual parameters: parent_0 k_m1 f_parent_to_m1 k1 k2 - 1e+02 5e-03 5e-01 6e-02 1e-02 + 1e+02 7e-03 5e-01 1e-01 2e-02 g 5e-01 @@ -35,37 +35,37 @@ Results: Likelihood computed by importance sampling AIC BIC logLik - 2369 2379 -1170 + 2334 2344 -1153 Optimised parameters: est. lower upper parent_0 1e+02 1e+02 1e+02 -k_m1 5e-03 4e-03 6e-03 +k_m1 7e-03 6e-03 7e-03 f_parent_to_m1 5e-01 4e-01 5e-01 -k1 6e-02 5e-02 7e-02 -k2 1e-02 9e-03 1e-02 -g 5e-01 4e-01 5e-01 +k1 1e-01 9e-02 1e-01 +k2 2e-02 2e-02 3e-02 +g 5e-01 5e-01 5e-01 Correlation: pr_0 k_m1 f___ k1 k2 -k_m1 -0.3 -f_parent_to_m1 -0.3 0.3 -k1 0.1 -0.1 -0.1 +k_m1 -0.2 +f_parent_to_m1 -0.3 0.1 +k1 0.1 0.0 0.0 k2 0.0 0.0 0.0 0.1 -g 0.1 -0.1 0.0 -0.3 -0.3 +g 0.1 -0.1 0.0 -0.2 -0.2 Random effects: est. lower upper -SD.parent_0 0.02 -89.53 89.6 -SD.k_m1 0.20 0.07 0.3 -SD.f_parent_to_m1 0.32 0.20 0.4 -SD.k1 0.38 0.23 0.5 -SD.k2 0.33 0.20 0.5 -SD.g 0.26 0.06 0.5 +SD.parent_0 0.03 -49.24 49.3 +SD.k_m1 0.23 0.13 0.3 +SD.f_parent_to_m1 0.30 0.19 0.4 +SD.k1 0.40 0.25 0.5 +SD.k2 0.34 0.21 0.5 +SD.g 0.21 0.06 0.4 Variance model: est. lower upper -a.1 0.90 0.76 1.03 +a.1 0.93 0.79 1.06 b.1 0.05 0.05 0.06 Resulting formation fractions: @@ -75,5 +75,5 @@ parent_sink 0.5 Estimated disappearance times: DT50 DT90 DT50back DT50_k1 DT50_k2 -parent 26 146 44 12 60 -m1 144 478 NA NA NA +parent 13 73 22 6 32 +m1 105 348 NA NA NA -- cgit v1.2.1