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<meta property="og:title" content="Functions to transform and backtransform kinetic parameters for fitting — transform_odeparms" />
<meta property="og:description" content="The transformations are intended to map parameters that should only take on
restricted values to the full scale of real numbers. For kinetic rate
constants and other parameters that can only take on positive values, a
simple log transformation is used. For compositional parameters, such as the
formations fractions that should always sum up to 1 and can not be negative,
the ilr transformation is used." />


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    <h1>Functions to transform and backtransform kinetic parameters for fitting</h1>
    <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/transform_odeparms.R'><code>R/transform_odeparms.R</code></a></small>
    <div class="hidden name"><code>transform_odeparms.Rd</code></div>
    </div>

    <div class="ref-description">
    <p>The transformations are intended to map parameters that should only take on
restricted values to the full scale of real numbers. For kinetic rate
constants and other parameters that can only take on positive values, a
simple log transformation is used. For compositional parameters, such as the
formations fractions that should always sum up to 1 and can not be negative,
the <a href='ilr.html'>ilr</a> transformation is used.</p>
    </div>

    <pre class="usage"><span class='fu'>transform_odeparms</span><span class='op'>(</span>
  <span class='va'>parms</span>,
  <span class='va'>mkinmod</span>,
  transform_rates <span class='op'>=</span> <span class='cn'>TRUE</span>,
  transform_fractions <span class='op'>=</span> <span class='cn'>TRUE</span>
<span class='op'>)</span>

<span class='fu'>backtransform_odeparms</span><span class='op'>(</span>
  <span class='va'>transparms</span>,
  <span class='va'>mkinmod</span>,
  transform_rates <span class='op'>=</span> <span class='cn'>TRUE</span>,
  transform_fractions <span class='op'>=</span> <span class='cn'>TRUE</span>
<span class='op'>)</span></pre>

    <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
    <table class="ref-arguments">
    <colgroup><col class="name" /><col class="desc" /></colgroup>
    <tr>
      <th>parms</th>
      <td><p>Parameters of kinetic models as used in the differential
equations.</p></td>
    </tr>
    <tr>
      <th>mkinmod</th>
      <td><p>The kinetic model of class <a href='mkinmod.html'>mkinmod</a>, containing
the names of the model variables that are needed for grouping the
formation fractions before <a href='ilr.html'>ilr</a> transformation, the parameter
names and the information if the pathway to sink is included in the model.</p></td>
    </tr>
    <tr>
      <th>transform_rates</th>
      <td><p>Boolean specifying if kinetic rate constants should
be transformed in the model specification used in the fitting for better
compliance with the assumption of normal distribution of the estimator. If
TRUE, also alpha and beta parameters of the FOMC model are
log-transformed, as well as k1 and k2 rate constants for the DFOP and HS
models and the break point tb of the HS model.</p></td>
    </tr>
    <tr>
      <th>transform_fractions</th>
      <td><p>Boolean specifying if formation fractions
constants should be transformed in the model specification used in the
fitting for better compliance with the assumption of normal distribution
of the estimator. The default (TRUE) is to do transformations.
The g parameter of the DFOP model is also seen as a fraction.
If a single fraction is transformed (g parameter of DFOP or only a single
target variable e.g. a single metabolite plus a pathway to sink), a
logistic transformation is used <code><a href='https://rdrr.io/r/stats/Logistic.html'>stats::qlogis()</a></code>. In other cases, i.e. if
two or more formation fractions need to be transformed whose sum cannot
exceed one, the <a href='ilr.html'>ilr</a> transformation is used.</p></td>
    </tr>
    <tr>
      <th>transparms</th>
      <td><p>Transformed parameters of kinetic models as used in the
fitting procedure.</p></td>
    </tr>
    </table>

    <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>

    <p>A vector of transformed or backtransformed parameters</p>
    <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2>

    <p>The transformation of sets of formation fractions is fragile, as it supposes
the same ordering of the components in forward and backward transformation.
This is no problem for the internal use in <a href='mkinfit.html'>mkinfit</a>.</p>
    <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2>

    <p>Johannes Ranke</p>

    <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
    <pre class="examples"><div class='input'>
<span class='va'>SFO_SFO</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>
  parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"m1"</span>, sink <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>,
  m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span>
</div><div class='output co'>#&gt; <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='co'># Fit the model to the FOCUS example dataset D using defaults</span>
<span class='va'>fit</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='va'>fit.s</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/pkg/saemix/man/summary-methods.html'>summary</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span>
<span class='co'># Transformed and backtransformed parameters</span>
<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.s</span><span class='op'>$</span><span class='va'>par</span>, <span class='fl'>3</span><span class='op'>)</span>
</div><div class='output co'>#&gt;                 Estimate Std. Error  Lower  Upper
#&gt; parent_0         99.5985     1.5702 96.404 102.79
#&gt; log_k_parent     -2.3157     0.0409 -2.399  -2.23
#&gt; log_k_m1         -5.2475     0.1332 -5.518  -4.98
#&gt; f_parent_qlogis   0.0579     0.0893 -0.124   0.24
#&gt; sigma             3.1255     0.3585  2.396   3.85</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.s</span><span class='op'>$</span><span class='va'>bpar</span>, <span class='fl'>3</span><span class='op'>)</span>
</div><div class='output co'>#&gt;                Estimate se_notrans t value   Pr(&gt;t)    Lower    Upper
#&gt; parent_0       99.59848    1.57022   63.43 2.30e-36 96.40383 102.7931
#&gt; k_parent        0.09870    0.00403   24.47 4.96e-23  0.09082   0.1073
#&gt; k_m1            0.00526    0.00070    7.51 6.16e-09  0.00401   0.0069
#&gt; f_parent_to_m1  0.51448    0.02230   23.07 3.10e-22  0.46912   0.5596
#&gt; sigma           3.12550    0.35852    8.72 2.24e-10  2.39609   3.8549</div><div class='input'>
<span class='co'># \dontrun{</span>
<span class='co'># Compare to the version without transforming rate parameters</span>
<span class='va'>fit.2</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_D</span>, transform_rates <span class='op'>=</span> <span class='cn'>FALSE</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='output co'>#&gt; <span class='error'>Error in if (cost &lt; cost.current) {    assign("cost.current", cost, inherits = TRUE)    if (!quiet)         cat(ifelse(OLS, "Sum of squared residuals", "Negative log-likelihood"),             " at call ", calls, ": ", signif(cost.current, 6),             "\n", sep = "")}: missing value where TRUE/FALSE needed</span></div><div class='output co'>#&gt; <span class='message'>Timing stopped at: 0.006 0 0.005</span></div><div class='input'><span class='va'>fit.2.s</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/pkg/saemix/man/summary-methods.html'>summary</a></span><span class='op'>(</span><span class='va'>fit.2</span><span class='op'>)</span>
</div><div class='output co'>#&gt; <span class='error'>Error in h(simpleError(msg, call)): error in evaluating the argument 'object' in selecting a method for function 'summary': object 'fit.2' not found</span></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.2.s</span><span class='op'>$</span><span class='va'>par</span>, <span class='fl'>3</span><span class='op'>)</span>
</div><div class='output co'>#&gt; <span class='error'>Error in h(simpleError(msg, call)): error in evaluating the argument 'x' in selecting a method for function 'print': object 'fit.2.s' not found</span></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.2.s</span><span class='op'>$</span><span class='va'>bpar</span>, <span class='fl'>3</span><span class='op'>)</span>
</div><div class='output co'>#&gt; <span class='error'>Error in h(simpleError(msg, call)): error in evaluating the argument 'x' in selecting a method for function 'print': object 'fit.2.s' not found</span></div><div class='input'><span class='co'># }</span>

<span class='va'>initials</span> <span class='op'>&lt;-</span> <span class='va'>fit</span><span class='op'>$</span><span class='va'>start</span><span class='op'>$</span><span class='va'>value</span>
<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>initials</span><span class='op'>)</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/r/base/colnames.html'>rownames</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>$</span><span class='va'>start</span><span class='op'>)</span>
<span class='va'>transformed</span> <span class='op'>&lt;-</span> <span class='va'>fit</span><span class='op'>$</span><span class='va'>start_transformed</span><span class='op'>$</span><span class='va'>value</span>
<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>transformed</span><span class='op'>)</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/r/base/colnames.html'>rownames</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>$</span><span class='va'>start_transformed</span><span class='op'>)</span>
<span class='fu'>transform_odeparms</span><span class='op'>(</span><span class='va'>initials</span>, <span class='va'>SFO_SFO</span><span class='op'>)</span>
</div><div class='output co'>#&gt;        parent_0    log_k_parent        log_k_m1 f_parent_qlogis 
#&gt;      100.750000       -2.302585       -2.301586        0.000000 </div><div class='input'><span class='fu'>backtransform_odeparms</span><span class='op'>(</span><span class='va'>transformed</span>, <span class='va'>SFO_SFO</span><span class='op'>)</span>
</div><div class='output co'>#&gt;       parent_0       k_parent           k_m1 f_parent_to_m1 
#&gt;       100.7500         0.1000         0.1001         0.5000 </div><div class='input'>
<span class='co'># \dontrun{</span>
<span class='co'># The case of formation fractions</span>
<span class='va'>SFO_SFO.ff</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>
  parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"m1"</span>, sink <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>,
  m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>,
  use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span>
</div><div class='output co'>#&gt; <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'>
<span class='va'>fit.ff</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO.ff</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='va'>fit.ff.s</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/pkg/saemix/man/summary-methods.html'>summary</a></span><span class='op'>(</span><span class='va'>fit.ff</span><span class='op'>)</span>
<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.ff.s</span><span class='op'>$</span><span class='va'>par</span>, <span class='fl'>3</span><span class='op'>)</span>
</div><div class='output co'>#&gt;                 Estimate Std. Error  Lower  Upper
#&gt; parent_0         99.5985     1.5702 96.404 102.79
#&gt; log_k_parent     -2.3157     0.0409 -2.399  -2.23
#&gt; log_k_m1         -5.2475     0.1332 -5.518  -4.98
#&gt; f_parent_qlogis   0.0579     0.0893 -0.124   0.24
#&gt; sigma             3.1255     0.3585  2.396   3.85</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.ff.s</span><span class='op'>$</span><span class='va'>bpar</span>, <span class='fl'>3</span><span class='op'>)</span>
</div><div class='output co'>#&gt;                Estimate se_notrans t value   Pr(&gt;t)    Lower    Upper
#&gt; parent_0       99.59848    1.57022   63.43 2.30e-36 96.40383 102.7931
#&gt; k_parent        0.09870    0.00403   24.47 4.96e-23  0.09082   0.1073
#&gt; k_m1            0.00526    0.00070    7.51 6.16e-09  0.00401   0.0069
#&gt; f_parent_to_m1  0.51448    0.02230   23.07 3.10e-22  0.46912   0.5596
#&gt; sigma           3.12550    0.35852    8.72 2.24e-10  2.39609   3.8549</div><div class='input'><span class='va'>initials</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"f_parent_to_m1"</span> <span class='op'>=</span> <span class='fl'>0.5</span><span class='op'>)</span>
<span class='va'>transformed</span> <span class='op'>&lt;-</span> <span class='fu'>transform_odeparms</span><span class='op'>(</span><span class='va'>initials</span>, <span class='va'>SFO_SFO.ff</span><span class='op'>)</span>
<span class='fu'>backtransform_odeparms</span><span class='op'>(</span><span class='va'>transformed</span>, <span class='va'>SFO_SFO.ff</span><span class='op'>)</span>
</div><div class='output co'>#&gt; f_parent_to_m1 
#&gt;            0.5 </div><div class='input'>
<span class='co'># And without sink</span>
<span class='va'>SFO_SFO.ff.2</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>
  parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"m1"</span>, sink <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span>,
  m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>,
  use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span>
</div><div class='output co'>#&gt; <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'>

<span class='va'>fit.ff.2</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO.ff.2</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
</div><div class='output co'>#&gt; <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='va'>fit.ff.2.s</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/pkg/saemix/man/summary-methods.html'>summary</a></span><span class='op'>(</span><span class='va'>fit.ff.2</span><span class='op'>)</span>
<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.ff.2.s</span><span class='op'>$</span><span class='va'>par</span>, <span class='fl'>3</span><span class='op'>)</span>
</div><div class='output co'>#&gt;              Estimate Std. Error Lower Upper
#&gt; parent_0        84.79      3.012 78.67 90.91
#&gt; log_k_parent    -2.76      0.082 -2.92 -2.59
#&gt; log_k_m1        -4.21      0.123 -4.46 -3.96
#&gt; sigma            8.22      0.943  6.31 10.14</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.ff.2.s</span><span class='op'>$</span><span class='va'>bpar</span>, <span class='fl'>3</span><span class='op'>)</span>
</div><div class='output co'>#&gt;          Estimate se_notrans t value   Pr(&gt;t)   Lower  Upper
#&gt; parent_0  84.7916    3.01203   28.15 1.92e-25 78.6704 90.913
#&gt; k_parent   0.0635    0.00521   12.19 2.91e-14  0.0538  0.075
#&gt; k_m1       0.0148    0.00182    8.13 8.81e-10  0.0115  0.019
#&gt; sigma      8.2229    0.94323    8.72 1.73e-10  6.3060 10.140</div><div class='input'><span class='co'># }</span>

</div></pre>
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