Kinetic nonlinear mixed-effects model fit by saem using nlmixr Structural model: d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) * parent d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) * parent - k_m1 * m1 Data: 507 observations of 2 variable(s) grouped in 15 datasets Likelihood: AIC BIC logLik 2510 2569 -1241 Fitted parameters: Est. SE %RSE Back-transformed(95%CI) BSV(CV% or SD) parent_0 100 0.444 0.442 100 (99.6, 101) 0.461 log_k_m1 -5.36 0.0804 1.5 0.00472 (0.00403, 0.00552) 21.5 f_parent_qlogis -0.0909 0.0868 95.5 0.477 (0.435, 0.52) 0.308 log_k1 -2.78 0.0977 3.51 0.0618 (0.0511, 0.0749) 30.1 log_k2 -4.51 0.08 1.77 0.011 (0.00941, 0.0129) 16.6 g_qlogis -0.121 0.17 141 0.47 (0.388, 0.553) 0.373 sigma_parent 3.72 3.72 sigma_m1 1.44 1.44 Shrink(SD)% parent_0 69.2%> log_k_m1 19.6%< f_parent_qlogis -0.136%> log_k1 6.71%< log_k2 23.7%= g_qlogis 19.5%< sigma_parent sigma_m1