ℹ Loading mkin Loading required package: parallel ℹ Testing mkin ✔ | OK F W S | Context ✔ | 5 | AIC calculation ✔ | 5 | Analytical solutions for coupled models [3.3 s] ✔ | 5 | Calculation of Akaike weights ✔ | 2 | Export dataset for reading into CAKE ✔ | 12 | Confidence intervals and p-values [1.3 s] ✔ | 14 | Error model fitting [4.7 s] ✔ | 5 | Time step normalisation ✔ | 4 | Calculation of FOCUS chi2 error levels [0.5 s] ✔ | 14 | Results for FOCUS D established in expertise for UBA (Ranke 2014) [0.8 s] ✔ | 4 | Test fitting the decline of metabolites from their maximum [0.3 s] ✔ | 1 | Fitting the logistic model [0.2 s] ✔ | 35 1 | Nonlinear mixed-effects models [27.1 s] ──────────────────────────────────────────────────────────────────────────────── Skip (test_mixed.R:161:3): saem results are reproducible for biphasic fits Reason: Fitting with saemix takes around 10 minutes when using deSolve ──────────────────────────────────────────────────────────────────────────────── ✔ | 2 | Test dataset classes mkinds and mkindsg ✔ | 10 | Special cases of mkinfit calls [0.4 s] ✔ | 1 | mkinfit features [0.3 s] ✔ | 8 | mkinmod model generation and printing [0.3 s] ✔ | 3 | Model predictions with mkinpredict [0.3 s] ✔ | 16 | Evaluations according to 2015 NAFTA guidance [1.7 s] ✔ | 9 | Nonlinear mixed-effects models with nlme [8.1 s] ✖ | 14 2 | Plotting [1.9 s] ──────────────────────────────────────────────────────────────────────────────── Failure (test_plot.R:40:5): Plotting mkinfit, mmkin and mixed model objects is reproducible Figures don't match: mixed-model-fit-for-saem-object-with-saemix-transformations.svg Failure (test_plot.R:55:5): Plotting mkinfit, mmkin and mixed model objects is reproducible Figures don't match: mixed-model-fit-for-saem-object-with-mkin-transformations.svg ──────────────────────────────────────────────────────────────────────────────── ✔ | 4 | Residuals extracted from mkinfit models ✔ | 2 | Complex test case from Schaefer et al. (2007) Piacenza paper [1.5 s] ✔ | 7 | Fitting the SFORB model [3.9 s] ✔ | 1 | Summaries of old mkinfit objects ✔ | 4 | Summary [0.1 s] ✔ | 4 | Results for synthetic data established in expertise for UBA (Ranke 2014) [2.2 s] ✔ | 9 | Hypothesis tests [8.2 s] ✔ | 4 | Calculation of maximum time weighted average concentrations (TWAs) [2.4 s] ══ Results ═════════════════════════════════════════════════════════════════════ Duration: 70.0 s ── Skipped tests ────────────────────────────────────────────────────────────── ● Fitting with saemix takes around 10 minutes when using deSolve (1) [ FAIL 2 | WARN 0 | SKIP 1 | PASS 204 ]