ℹ Loading mkin Loading required package: parallel ℹ Testing mkin ✔ | F W S OK | Context ⠏ | 0 | AIC ⠏ | 0 | AIC calculation ✔ | 5 | AIC calculation ⠏ | 0 | analytical ⠏ | 0 | Analytical solutions for coupled models ⠋ | 1 | Analytical solutions for coupled models ⠙ | 2 | Analytical solutions for coupled models ⠹ | 3 | Analytical solutions for coupled models ⠸ | 4 | Analytical solutions for coupled models ⠼ | 5 | Analytical solutions for coupled models ✔ | 5 | Analytical solutions for coupled models [3.4s] ⠏ | 0 | aw ⠏ | 0 | Calculation of Akaike weights ✔ | 5 | Calculation of Akaike weights ⠏ | 0 | CAKE_export ⠏ | 0 | Export dataset for reading into CAKE ✔ | 2 | Export dataset for reading into CAKE ⠏ | 0 | confidence ⠏ | 0 | Confidence intervals and p-values ⠼ | 5 | Confidence intervals and p-values ⠋ | 11 | Confidence intervals and p-values ⠙ | 12 | Confidence intervals and p-values ✔ | 12 | Confidence intervals and p-values [1.0s] ⠏ | 0 | error_models ⠏ | 0 | Error model fitting ⠹ | 3 | Error model fitting ⠸ | 4 | Error model fitting ⠼ | 5 | Error model fitting ⠴ | 6 | Error model fitting ⠧ | 8 | Error model fitting ⠏ | 10 | Error model fitting ⠙ | 12 | Error model fitting ⠸ | 14 | Error model fitting ✔ | 14 | Error model fitting [4.9s] ⠏ | 0 | f_time_norm ⠏ | 0 | Time step normalisation ✔ | 5 | Time step normalisation ⠏ | 0 | FOCUS_chi2_error_level ⠏ | 0 | Calculation of FOCUS chi2 error levels ⠙ | 2 | Calculation of FOCUS chi2 error levels ⠸ | 4 | Calculation of FOCUS chi2 error levels ✔ | 4 | Calculation of FOCUS chi2 error levels [0.6s] ⠏ | 0 | FOCUS_D_UBA_expertise ⠏ | 0 | Results for FOCUS D established in expertise for UBA (Ranke 2014) ⠋ | 1 | Results for FOCUS D established in expertise for UBA (Ranke 2014) ⠧ | 8 | Results for FOCUS D established in expertise for UBA (Ranke 2014) ⠏ | 10 | Results for FOCUS D established in expertise for UBA (Ranke 2014) ✔ | 14 | Results for FOCUS D established in expertise for UBA (Ranke 2014) [0.8s] ⠏ | 0 | from_max_mean ⠏ | 0 | Test fitting the decline of metabolites from their maximum ⠹ | 3 | Test fitting the decline of metabolites from their maximum ⠸ | 4 | Test fitting the decline of metabolites from their maximum ✔ | 4 | Test fitting the decline of metabolites from their maximum [0.3s] ⠏ | 0 | logistic ⠏ | 0 | Fitting the logistic model ⠋ | 1 | Fitting the logistic model ✔ | 1 | Fitting the logistic model [0.2s] ⠏ | 0 | mixed ⠏ | 0 | Nonlinear mixed-effects models ⠙ | 2 | Nonlinear mixed-effects models ⠹ | 3 | Nonlinear mixed-effects models ⠸ | 4 | Nonlinear mixed-effects models ⠏ | 10 | Nonlinear mixed-effects models ⠙ | 12 | Nonlinear mixed-effects models ⠧ | 18 | Nonlinear mixed-effects models ⠙ | 22 | Nonlinear mixed-effects models ⠹ | 23 | Nonlinear mixed-effects models ✔ | 1 35 | Nonlinear mixed-effects models [26.6s] ──────────────────────────────────────────────────────────────────────────────── Skip (test_mixed.R:161:3): saem results are reproducible for biphasic fits Reason: Fitting with saemix takes around 10 minutes when using deSolve ──────────────────────────────────────────────────────────────────────────────── ⠏ | 0 | mkinds ⠏ | 0 | Test dataset classes mkinds and mkindsg ✔ | 2 | Test dataset classes mkinds and mkindsg ⠏ | 0 | mkinfit_errors ⠏ | 0 | Special cases of mkinfit calls ⠇ | 9 | Special cases of mkinfit calls ⠏ | 10 | Special cases of mkinfit calls ✔ | 10 | Special cases of mkinfit calls [0.4s] ⠏ | 0 | mkinfit ⠏ | 0 | mkinfit features ⠋ | 1 | mkinfit features ✔ | 1 | mkinfit features [0.3s] ⠏ | 0 | mkinmod ⠏ | 0 | mkinmod model generation and printing ⠧ | 8 | mkinmod model generation and printing ✔ | 8 | mkinmod model generation and printing [0.2s] ⠏ | 0 | mkinpredict_SFO_SFO ⠏ | 0 | Model predictions with mkinpredict ⠋ | 1 | Model predictions with mkinpredict ✔ | 3 | Model predictions with mkinpredict [0.3s] ⠏ | 0 | nafta ⠏ | 0 | Evaluations according to 2015 NAFTA guidance ⠙ | 2 | Evaluations according to 2015 NAFTA guidance ⠇ | 9 | Evaluations according to 2015 NAFTA guidance ⠏ | 10 | Evaluations according to 2015 NAFTA guidance ✔ | 16 | Evaluations according to 2015 NAFTA guidance [1.5s] ⠏ | 0 | nlme ⠏ | 0 | Nonlinear mixed-effects models with nlme ⠋ | 1 | Nonlinear mixed-effects models with nlme ⠙ | 2 | Nonlinear mixed-effects models with nlme ⠼ | 5 | Nonlinear mixed-effects models with nlme ⠴ | 6 | Nonlinear mixed-effects models with nlme ⠧ | 8 | Nonlinear mixed-effects models with nlme ⠇ | 9 | Nonlinear mixed-effects models with nlme ✔ | 9 | Nonlinear mixed-effects models with nlme [8.3s] ⠏ | 0 | nlmixr ⠏ | 0 | plot ⠏ | 0 | Plotting ⠋ | 1 | Plotting ⠇ | 9 | Plotting ⠹ | 13 | Plotting ⠼ | 15 | Plotting ✔ | 16 | Plotting [1.3s] ⠏ | 0 | residuals ⠏ | 0 | Residuals extracted from mkinfit models ✔ | 4 | Residuals extracted from mkinfit models ⠏ | 0 | schaefer07_complex_case ⠏ | 0 | Complex test case from Schaefer et al. (2007) Piacenza paper ⠋ | 1 | Complex test case from Schaefer et al. (2007) Piacenza paper ✔ | 2 | Complex test case from Schaefer et al. (2007) Piacenza paper [1.5s] ⠏ | 0 | SFORB ⠏ | 0 | Fitting the SFORB model ⠋ | 1 | Fitting the SFORB model ⠼ | 5 | Fitting the SFORB model ✔ | 7 | Fitting the SFORB model [3.9s] ⠏ | 0 | summary_old_objects ⠏ | 0 | Summaries of old mkinfit objects ✔ | 1 | Summaries of old mkinfit objects ⠏ | 0 | summary ⠏ | 0 | Summary ⠸ | 4 | Summary ✔ | 4 | Summary [0.1s] ⠏ | 0 | synthetic_data_for_UBA_2014 ⠏ | 0 | Results for synthetic data established in expertise for UBA (Ranke 2014) ⠋ | 1 | Results for synthetic data established in expertise for UBA (Ranke 2014) ⠹ | 3 | Results for synthetic data established in expertise for UBA (Ranke 2014) ✔ | 4 | Results for synthetic data established in expertise for UBA (Ranke 2014) [2.3s] ⠏ | 0 | tests ⠏ | 0 | Hypothesis tests ⠼ | 5 | Hypothesis tests ⠴ | 6 | Hypothesis tests ⠧ | 8 | Hypothesis tests ⠇ | 9 | Hypothesis tests ✔ | 9 | Hypothesis tests [8.5s] ⠏ | 0 | twa ⠏ | 0 | Calculation of maximum time weighted average concentrations (TWAs) ⠋ | 1 | Calculation of maximum time weighted average concentrations (TWAs) ⠙ | 2 | Calculation of maximum time weighted average concentrations (TWAs) ⠹ | 3 | Calculation of maximum time weighted average concentrations (TWAs) ⠸ | 4 | Calculation of maximum time weighted average concentrations (TWAs) ✔ | 4 | Calculation of maximum time weighted average concentrations (TWAs) [2.2s] ══ Results ═════════════════════════════════════════════════════════════════════ Duration: 69.0 s ── Skipped tests ────────────────────────────────────────────────────────────── • Fitting with saemix takes around 10 minutes when using deSolve (1) [ FAIL 0 | WARN 0 | SKIP 1 | PASS 206 ]