ℹ Loading mkin
Loading required package: parallel
ℹ Testing mkin
✔ | F W S  OK | Context
✔ |         5 | AIC calculation
✔ |         5 | Analytical solutions for coupled models [14.4s]
✔ |         5 | Calculation of Akaike weights
✔ |         2 | Export dataset for reading into CAKE
✔ |        12 | Confidence intervals and p-values [1.0s]
⠋ |         1 | Dimethenamid data from 2018                                     
✔ |     1  27 | Dimethenamid data from 2018 [124.8s]
────────────────────────────────────────────────────────────────────────────────
Skip (test_dmta.R:164:3): Different backends get consistent results for SFO-SFO3+, dimethenamid data
Reason: Fitting this ODE model with saemix takes about 15 minutes on my system
────────────────────────────────────────────────────────────────────────────────
✔ |        14 | Error model fitting [6.8s]
✔ |         5 | Time step normalisation
✔ |         4 | Calculation of FOCUS chi2 error levels [0.8s]
✔ |        14 | Results for FOCUS D established in expertise for UBA (Ranke 2014) [3.5s]
✔ |         4 | Test fitting the decline of metabolites from their maximum [0.6s]
✔ |         1 | Fitting the logistic model [0.3s]
⠇ | 1       8 | Nonlinear mixed-effects models                                  
✖ | 1   1  13 | Nonlinear mixed-effects models [1.5s]
────────────────────────────────────────────────────────────────────────────────
Failure (test_mixed.R:5:3): Print methods work
Results have changed from known value recorded in 'print_mmkin_dfop_1_mixed.txt'.

old[18:21] vs new[18:21]
  ""
  "Mean fitted parameters:"
  "parent_0   log_k1   log_k2 g_qlogis "
- "  100.06    -2.68    -5.57     0.01 "
+ "  100.06    -2.68    -5.58     0.01 "

Skip (test_mixed.R:68:3): saemix results are reproducible for biphasic fits
Reason: Fitting with saemix takes around 10 minutes when using deSolve
────────────────────────────────────────────────────────────────────────────────
✔ |         3 | Test dataset classes mkinds and mkindsg
✔ |        10 | Special cases of mkinfit calls [0.6s]
✔ |         3 | mkinfit features [1.1s]
✔ |         8 | mkinmod model generation and printing [0.2s]
✔ |         3 | Model predictions with mkinpredict [0.3s]
✔ |        16 | Evaluations according to 2015 NAFTA guidance [2.1s]
✔ |         9 | Nonlinear mixed-effects models with nlme [8.5s]
✖ | 2      14 | Plotting [1.5s]
────────────────────────────────────────────────────────────────────────────────
Failure (test_plot.R:42:3): Plotting mkinfit, mmkin and mixed model objects is reproducible
Snapshot of `testcase` to 'plot/mixed-model-fit-for-nlme-object.svg' has changed
Run `testthat::snapshot_review('plot/')` to review changes
Backtrace:
 1. vdiffr::expect_doppelganger(...)
      at test_plot.R:42:2
 3. testthat::expect_snapshot_file(...)

Failure (test_plot.R:50:3): Plotting mkinfit, mmkin and mixed model objects is reproducible
Snapshot of `testcase` to 'plot/mixed-model-fit-for-saem-object-with-mkin-transformations.svg' has changed
Run `testthat::snapshot_review('plot/')` to review changes
Backtrace:
 1. vdiffr::expect_doppelganger(...)
      at test_plot.R:50:2
 3. testthat::expect_snapshot_file(...)
────────────────────────────────────────────────────────────────────────────────
✔ |         4 | Residuals extracted from mkinfit models
✔ |        23 | saemix_parent [28.7s]
✔ |         2 | Complex test case from Schaefer et al. (2007) Piacenza paper [12.2s]
✔ |         7 | Fitting the SFORB model [16.1s]
✔ |         1 | Summaries of old mkinfit objects
✔ |         4 | Summary [0.1s]
✔ |         4 | Results for synthetic data established in expertise for UBA (Ranke 2014) [19.0s]
✔ |         9 | Hypothesis tests [67.6s]
✔ |         2 | tffm0
✔ |         4 | Calculation of maximum time weighted average concentrations (TWAs) [2.0s]

══ Results ═════════════════════════════════════════════════════════════════════
Duration: 314.2 s

── Skipped tests  ──────────────────────────────────────────────────────────────
• Fitting this ODE model with saemix takes about 15 minutes on my system (1)
• Fitting with saemix takes around 10 minutes when using deSolve (1)

[ FAIL 3 | WARN 0 | SKIP 2 | PASS 237 ]