Kinetic nonlinear mixed-effects model fit by saem using nlmixr Structural model: d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) * parent d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) * parent - k_m1 * m1 Data: 507 observations of 2 variable(s) grouped in 15 datasets Likelihood: AIC BIC logLik 2400 2468 -1184 Fitted parameters: Est. SE %RSE Back-transformed(95%CI) BSV(CV% or SD) parent_0 100 0.685 0.682 100 (99, 102) 0.278 log_k_m1 -5.35 0.0812 1.52 0.00477 (0.00407, 0.00559) 13.7 f_parent_qlogis -0.091 0.096 106 0.477 (0.431, 0.524) 0.320 log_k1 -2.76 0.0969 3.5 0.063 (0.0521, 0.0762) 29.9 log_k2 -4.49 0.0658 1.47 0.0113 (0.00991, 0.0128) 18.6 g_qlogis -0.167 0.142 85.3 0.458 (0.39, 0.528) 0.339 sigma_low_parent 1.04 1.04 rsd_high_parent 0.0531 0.0531 sigma_low_m1 0.819 0.819 rsd_high_m1 0.058 0.058 Shrink(SD)% parent_0 87.7%> log_k_m1 44.8%> f_parent_qlogis -0.375%> log_k1 6.76%< log_k2 10.4%< g_qlogis 20.3%= sigma_low_parent rsd_high_parent sigma_low_m1 rsd_high_m1