From df2e56c3ec7b166a2d329cf41ef58ec268910f44 Mon Sep 17 00:00:00 2001 From: Johannes Ranke Date: Thu, 10 Sep 2026 12:42:19 +0200 Subject: Update online docs --- docs/reference/pfm_degradation.html | 30 +++++++++++++++++++++++++++++- 1 file changed, 29 insertions(+), 1 deletion(-) (limited to 'docs/reference/pfm_degradation.html') diff --git a/docs/reference/pfm_degradation.html b/docs/reference/pfm_degradation.html index b4f3279..22d90ca 100644 --- a/docs/reference/pfm_degradation.html +++ b/docs/reference/pfm_degradation.html @@ -85,6 +85,12 @@ is calculated (SFO model).

The output times

+
+

Value

+

A data frame containing the output times and the concentrations +assuming initial concentrations of 1 for the parent and zero for +metabolites, if any.

+

Author

Johannes Ranke

@@ -92,7 +98,9 @@ is calculated (SFO model).

Examples

- 
head(pfm_degradation("SFO", DT50 = 10))
+    
# Simple example of an SFO decline curve
+sfo_out <- pfm_degradation("SFO", DT50 = 10)
+head(sfo_out)
 #>   time    parent
 #> 0    0 1.0000000
 #> 1    1 0.9330330
@@ -100,6 +108,26 @@ is calculated (SFO model).

 #> 3    3 0.8122524
 #> 4    4 0.7578583
 #> 5    5 0.7071068
+
+# Fictive example with a metabolite where we first generate an SFO-SFO model
+sfo_sfo <- mkinmod(
+  parent = mkinsub("SFO", to = "metabolite"),
+  metabolite = mkinsub("SFO"))
+#> Temporary DLL for differentials generated and loaded
+
+sfo_sfo_out <- pfm_degradation(sfo_sfo,
+  parms = c(k_parent = 0.1, f_parent_to_metabolite = 0.5, k_metabolite = 0.02))
+
+plot(
+  sfo_sfo_out[, "time"],
+  sfo_sfo_out[, "parent"], type = "l",
+  xlab = "Time", ylab = "Relative concentration",
+  xlim = c(0, 100))
+lines(
+  sfo_sfo_out[, "time"],
+  sfo_sfo_out[, "metabolite"], lty = 2)
+
+