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+<html><head><title>Fit dose-response models</title>
+<link rel="stylesheet" type="text/css" href="Rchm.css">
+</head>
+<body>
+
+<table width="100%"><tr><td>drfit(drfit)</td><td align="right">R Documentation</td></tr></table><object type="application/x-oleobject" classid="clsid:1e2a7bd0-dab9-11d0-b93a-00c04fc99f9e">
+<param name="keyword" value="R:   drfit">
+<param name="keyword" value=" Fit dose-response models">
+</object>
+
+
+<h2>Fit dose-response models</h2>
+
+
+<h3>Description</h3>
+
+<p>
+Fit dose-response relationships to dose-response data and calculate
+biometric results for (eco)toxicity evaluation
+</p>
+
+
+<h3>Usage</h3>
+
+<pre>
+  drfit(data, startlogEC50 = NA, lognorm = TRUE, logis = FALSE, 
+    linearlogis = FALSE, b0 = 2, f0 = 0)
+</pre>
+
+
+<h3>Arguments</h3>
+
+<table summary="R argblock">
+<tr valign="top"><td><code>data</code></td>
+<td>
+A data frame as returned from <code><a href="drdata.html">drdata</a></code>.  The data frame has to
+contain at least a factor called "substance", a vector called "unit"
+containing the unit used for the dose, a column "response" with the
+response values of the test system normalized between 0 and 1 and a column
+"dose" with the numeric dose values. For later use of the
+<code><a href="drplot.html">drplot</a></code> function, a factor called "dosefactor" also has to be
+present, containing the dose as a factor.
+</td></tr>
+<tr valign="top"><td><code>startlogEC50</code></td>
+<td>
+Especially for the linearlogis model, a suitable log10 of the EC50 has to be given 
+by the user, since it is not correctly estimated for data showing hormesis with
+the default estimation method.</td></tr>
+<tr valign="top"><td><code>lognorm</code></td>
+<td>
+A boolean defining if cumulative density curves of normal distributions
+are fitted to the data. Default ist TRUE.</td></tr>
+<tr valign="top"><td><code>logis</code></td>
+<td>
+A boolean defining if cumulative densitiy curves of logistic distributions
+are fitted to the data. Default is FALSE.</td></tr>
+<tr valign="top"><td><code>linearlogis</code></td>
+<td>
+A boolean defining if the linear-logistic function as defined by van Ewijk and Hoekstra
+1993 is fitted to the data. Default is FALSE.</td></tr>
+<tr valign="top"><td><code>b0,f0</code></td>
+<td>
+If the linearlogistic model is fitted, b0 and f0 give the possibility to
+adapt the starting values for the parameters b and f.</td></tr>
+</table>
+
+<h3>Value</h3>
+
+<table summary="R argblock">
+<tr valign="top"><td><code>results</code></td>
+<td>
+A data frame containing at least one line for each substance. If the data did not
+show a mean response &lt; 0.5 at the highest dose level, the modeltype is set to "none".
+Every successful fit is reported in one line. Parameters of the fitted curves are only
+reported if the fitted EC50 is not higher than the highest dose.</td></tr>
+</table>
+
+<h3>Author(s)</h3>
+
+<p>
+Johannes Ranke 
+<a href="mailto:jranke@uni-bremen.de">jranke@uni-bremen.de</a> 
+<a href="http://www.uft.uni-bremen.de/chemie/ranke">http://www.uft.uni-bremen.de/chemie/ranke</a>
+</p>
+
+
+<h3>Examples</h3>
+
+<pre>
+## Not run: data(antifoul)
+## Not run: r &lt;- drfit(antifoul)
+## Not run: format(r,digits=2)
+</pre>
+
+
+
+<hr><div align="center"><a href="00Index.html">[Package Contents]</a></div>
+
+</body></html>