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checksubstance <- function(substance, db = "cytotox", experimentator = "%",
celltype = "%", enzymetype = "%", organism = "%",
endpoint = "%",
whereClause = "1", ok= "%")
{
databases <- data.frame(
responsename=c("viability","activity","response"),
testtype=c("celltype","enzyme","organism"),
exptype=c("plate","plate","experiment"))
rownames(databases) <- c("cytotox","enzymes","ecotox")
if (!(db %in% rownames(databases))) stop("Database is not supported")
if (requireNamespace("RODBC")) {
channel <- RODBC::odbcConnect(db, uid="cytotox", pwd="cytotox", case="tolower")
} else {
stop("For this function, the RODBC package has to be installed and configured.")
}
responsename = as.character(databases[db,1])
testtype = as.character(databases[db,2])
exptype = as.character(databases[db,3])
if (db == "cytotox") {
type <- celltype
}
if (db == "enzymes") {
type <- enzymetype
}
if (db == "ecotox") {
type <- organism
}
query <- paste("SELECT experimentator,substance,",
testtype, ",", exptype, ",conc,unit,",responsename,",ok",
" FROM ",db," WHERE substance LIKE '",
substance,"' AND experimentator LIKE '",
experimentator,"' AND ",testtype," LIKE '",
type,"' AND ",
whereClause," AND ok LIKE '",ok,"'",
sep = "")
if (db == "ecotox") {
query <- paste(query, " AND type LIKE '",
endpoint, "'", sep = "")
}
data <- RODBC::sqlQuery(channel,query)
RODBC::odbcClose(channel)
if (length(data$experimentator) < 1) {
stop(paste("\nNo response data for",substance,"in database",
db,"found with these parameters\n"))
}
data$experimentator <- factor(data$experimentator)
data$substance <- factor(data$substance)
substances <- levels(data$substance)
data$type <- factor(data[[testtype]])
data[[exptype]] <- factor(data[[exptype]])
experiments <- levels(data[[exptype]])
concentrations <- split(data$conc,data$conc)
concentrations <- as.numeric(names(concentrations))
data$unit <- factor(data$unit)
data$ok <- factor(data$ok)
if (length(experiments)>6) {
palette(rainbow(length(experiments)))
}
plot(log10(data$conc),data[[responsename]],
xlim=c(-2.5, 4.5),
ylim= c(-0.1, 2),
xlab=paste("decadic logarithm of the concentration in ",levels(data$unit)),
ylab=responsename)
explist <- split(data,data[[exptype]])
for (i in 1:length(explist)) {
points(log10(explist[[i]]$conc),explist[[i]][[responsename]],col=i);
}
legend("topleft", experiments, pch=1, col=1:length(experiments), inset=0.05)
title(main=paste(substance," - ",levels(data$experimentator)," - ",levels(data$type)))
exptypename <- paste(toupper(substring(exptype,1,1)),
substring(exptype,2), sep = "")
experimentators <- paste(levels(data$experimentator), collapse = " ")
types <- paste(levels(data$type), collapse = " ")
experiments <- paste(levels(data[[exptype]]), collapse = " ")
class(experiments)
cat("\n\tSubstanz:\t\t",substance,"\n",
"\tExperimentator(s):\t", experimentators,"\n",
"\tType(s): \t\t",types,"\n",
"\tEndpoint: \t\t",endpoint,"\n",
"\t", exptypename, "(s):\t\t",experiments,"\n\n", sep = "")
}
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