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<!DOCTYPE html>
<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Dose-Response data for 1-methyl-3-alkylimidazolium tetrafluoroborates in IPC-81 cells — IM1xIPC81 • drfit</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Dose-Response data for 1-methyl-3-alkylimidazolium tetrafluoroborates in IPC-81 cells — IM1xIPC81"><meta property="og:description" content="This is the raw data documenting the influence of the alkyl
chain length in 3 position on the toxicity to the
promyelocytic leukemia rat cell line IPC-81. The substances
are named according to the UFT naming scheme of these
substances. IM13 BF4 means 1-methyl-3-propylimidazolium
tetrafluoroborate, IM14 BF4 means
1-methyl-3-butylimidazolium tetrafluoroborate and IM1-10
BF4 means 1-methyl-3-decylimidazolium tetrafluoroborate.
This is a subset (only the BF4 anion) of the data
shown in Figure 3 in Ranke et al. (2004)."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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<h1>Dose-Response data for 1-methyl-3-alkylimidazolium tetrafluoroborates in IPC-81 cells</h1>
<div class="hidden name"><code>IM1xIPC81.Rd</code></div>
</div>
<div class="ref-description">
<p>This is the raw data documenting the influence of the alkyl
chain length in 3 position on the toxicity to the
promyelocytic leukemia rat cell line IPC-81. The substances
are named according to the UFT naming scheme of these
substances. IM13 BF4 means 1-methyl-3-propylimidazolium
tetrafluoroborate, IM14 BF4 means
1-methyl-3-butylimidazolium tetrafluoroborate and IM1-10
BF4 means 1-methyl-3-decylimidazolium tetrafluoroborate.
This is a subset (only the BF4 anion) of the data
shown in Figure 3 in Ranke et al. (2004).</p>
</div>
<div id="ref-usage">
<div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu"><a href="https://rdrr.io/r/utils/data.html" class="external-link">data</a></span><span class="op">(</span><span class="va">IM1xIPC81</span><span class="op">)</span></span></code></pre></div>
</div>
<div id="format">
<h2>Format</h2>
<p>A dataframe containing the data as required for the
<code><a href="drfit.html">drfit</a></code> function. An additional column contains
the tested organism (name of the cell line).</p>
</div>
<div id="source">
<h2>Source</h2>
<p>Ranke J, Mölter K, Stock F, Bottin-Weber U, Poczobutt J,
Hoffmann J, Ondruschka B, Filser J, Jastorff B (2004)
Biological effects of imidazolium ionic liquids with varying
chain lenghts in acute Vibrio fischeri and WST-1 cell
viability assays. Ecotoxicology and Environmental Safety
58(3) 396-404</p>
</div>
<div id="ref-examples">
<h2>Examples</h2>
<div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span> <span class="va">rIM1xIPC81</span> <span class="op"><-</span> <span class="fu"><a href="drfit.html">drfit</a></span><span class="op">(</span><span class="va">IM1xIPC81</span>, linlogit <span class="op">=</span> <span class="cn">TRUE</span>, showED50 <span class="op">=</span> <span class="cn">TRUE</span>, EDx <span class="op">=</span> <span class="fl">10</span><span class="op">)</span></span></span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM13 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM14 BF4: Fitting data...</span>
<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>NaNs produced</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM15 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM16 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM17 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> Waiting for profiling to be done...</span>
<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>NaNs produced</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM18 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> Waiting for profiling to be done...</span>
<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>NaNs produced</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM19 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> Waiting for profiling to be done...</span>
<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>NaNs produced</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM1-10 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> Waiting for profiling to be done...</span>
<span class="r-in"><span></span></span>
<span class="r-in"><span> <span class="va">rIM1xIPC81.drc</span> <span class="op"><-</span> <span class="fu"><a href="drcfit.html">drcfit</a></span><span class="op">(</span><span class="va">IM1xIPC81</span>, linlogit <span class="op">=</span> <span class="cn">TRUE</span>, showED50 <span class="op">=</span> <span class="cn">TRUE</span>, EDx <span class="op">=</span> <span class="fl">10</span><span class="op">)</span></span></span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM13 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM14 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM15 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM16 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM17 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM18 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM19 BF4: Fitting data...</span>
<span class="r-msg co"><span class="r-pr">#></span> </span>
<span class="r-msg co"><span class="r-pr">#></span> IM1-10 BF4: Fitting data...</span>
<span class="r-in"><span></span></span>
<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">rIM1xIPC81</span>,digits<span class="op">=</span><span class="fl">4</span><span class="op">)</span></span></span>
<span class="r-out co"><span class="r-pr">#></span> Substance ndl n lld lhd mtype logED50 2.5% 97.5% unit sigma</span>
<span class="r-out co"><span class="r-pr">#></span> 1 IM13 BF4 9 81 0.5918 3.000 inactive NA NA NA microM NA</span>
<span class="r-out co"><span class="r-pr">#></span> 2 IM14 BF4 20 216 -0.0103 3.176 no fit NA NA NA microM NA</span>
<span class="r-out co"><span class="r-pr">#></span> 3 IM15 BF4 9 135 0.5918 3.000 inactive NA NA NA microM NA</span>
<span class="r-out co"><span class="r-pr">#></span> 4 IM16 BF4 9 108 0.5918 3.000 inactive NA NA NA microM NA</span>
<span class="r-out co"><span class="r-pr">#></span> 5 IM17 BF4 9 81 0.5918 3.000 linlogit 2.5786 2.506 2.6617 microM 0.2376</span>
<span class="r-out co"><span class="r-pr">#></span> 6 IM18 BF4 9 135 0.5918 3.000 linlogit 1.6806 1.623 1.7419 microM 0.2325</span>
<span class="r-out co"><span class="r-pr">#></span> 7 IM19 BF4 9 81 0.5918 3.000 linlogit 1.6496 1.598 1.7031 microM 0.1453</span>
<span class="r-out co"><span class="r-pr">#></span> 8 IM1-10 BF4 11 162 -0.0103 3.000 linlogit 0.7697 0.687 0.8544 microM 0.2988</span>
<span class="r-out co"><span class="r-pr">#></span> a b c ED50 ED50 2.5% ED50 97.5% EDx10</span>
<span class="r-out co"><span class="r-pr">#></span> 1 NA NA NA NA NA NA NA</span>
<span class="r-out co"><span class="r-pr">#></span> 2 NA NA NA NA NA NA NA</span>
<span class="r-out co"><span class="r-pr">#></span> 3 NA NA NA NA NA NA NA</span>
<span class="r-out co"><span class="r-pr">#></span> 4 NA NA NA NA NA NA NA</span>
<span class="r-out co"><span class="r-pr">#></span> 5 2.5786 2.300 0.01468 378.941 320.424 458.918 230.782</span>
<span class="r-out co"><span class="r-pr">#></span> 6 1.6806 2.237 0.05719 47.930 41.973 55.194 27.367</span>
<span class="r-out co"><span class="r-pr">#></span> 7 1.6496 1.977 0.10956 44.628 39.671 50.483 23.031</span>
<span class="r-out co"><span class="r-pr">#></span> 8 0.7697 1.936 0.45809 5.884 4.864 7.152 2.835</span>
<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">rIM1xIPC81.drc</span>,digits<span class="op">=</span><span class="fl">4</span><span class="op">)</span></span></span>
<span class="r-out co"><span class="r-pr">#></span> Substance ndl n lld lhd mtype logED50 2.5% 97.5% unit sigma</span>
<span class="r-out co"><span class="r-pr">#></span> 1 IM13 BF4 9 81 0.5918 3.000 inactive NA NA NA microM NA</span>
<span class="r-out co"><span class="r-pr">#></span> 2 IM14 BF4 20 216 -0.0103 3.176 linlogit NA NA NA microM 0.1529</span>
<span class="r-out co"><span class="r-pr">#></span> 3 IM15 BF4 9 135 0.5918 3.000 inactive NA NA NA microM NA</span>
<span class="r-out co"><span class="r-pr">#></span> 4 IM16 BF4 9 108 0.5918 3.000 inactive NA NA NA microM NA</span>
<span class="r-out co"><span class="r-pr">#></span> 5 IM17 BF4 9 81 0.5918 3.000 linlogit 2.5786 2.4935 2.6497 microM 0.2376</span>
<span class="r-out co"><span class="r-pr">#></span> 6 IM18 BF4 9 135 0.5918 3.000 linlogit 1.6806 1.6168 1.7362 microM 0.2325</span>
<span class="r-out co"><span class="r-pr">#></span> 7 IM19 BF4 9 81 0.5918 3.000 linlogit 1.6496 1.5940 1.6990 microM 0.1453</span>
<span class="r-out co"><span class="r-pr">#></span> 8 IM1-10 BF4 11 162 -0.0103 3.000 linlogit 0.7697 0.6774 0.8458 microM 0.2988</span>
<span class="r-out co"><span class="r-pr">#></span> a b c ED50 ED50 2.5% ED50 97.5% EDx10 EDx10 2.5%</span>
<span class="r-out co"><span class="r-pr">#></span> 1 NA NA NA NA NA NA NA NA</span>
<span class="r-out co"><span class="r-pr">#></span> 2 5.390e+15 0.3148 -0.0001736 NA NA NA NA NA</span>
<span class="r-out co"><span class="r-pr">#></span> 3 NA NA NA NA NA NA NA NA</span>
<span class="r-out co"><span class="r-pr">#></span> 4 NA NA NA NA NA NA NA NA</span>
<span class="r-out co"><span class="r-pr">#></span> 5 1.281e+02 2.3001 0.0146821 378.964 311.555 446.372 230.790 202.915</span>
<span class="r-out co"><span class="r-pr">#></span> 6 2.079e+01 2.2373 0.0571925 47.930 41.382 54.478 27.367 23.809</span>
<span class="r-out co"><span class="r-pr">#></span> 7 1.342e+01 1.9773 0.1094542 44.630 39.260 50.000 23.036 20.614</span>
<span class="r-out co"><span class="r-pr">#></span> 8 2.258e+00 1.9362 0.4580784 5.884 4.758 7.011 2.835 2.181</span>
<span class="r-out co"><span class="r-pr">#></span> EDx10 97.5%</span>
<span class="r-out co"><span class="r-pr">#></span> 1 NA</span>
<span class="r-out co"><span class="r-pr">#></span> 2 NA</span>
<span class="r-out co"><span class="r-pr">#></span> 3 NA</span>
<span class="r-out co"><span class="r-pr">#></span> 4 NA</span>
<span class="r-out co"><span class="r-pr">#></span> 5 258.665</span>
<span class="r-out co"><span class="r-pr">#></span> 6 30.925</span>
<span class="r-out co"><span class="r-pr">#></span> 7 25.459</span>
<span class="r-out co"><span class="r-pr">#></span> 8 3.489</span>
</code></pre></div>
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