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| author | Johannes Ranke <jranke@uni-bremen.de> | 2015-10-22 17:30:09 +0200 |
|---|---|---|
| committer | Johannes Ranke <jranke@uni-bremen.de> | 2015-10-22 17:30:09 +0200 |
| commit | c737c606058cb4c2a0805e2bec8ce356d01a627a (patch) | |
| tree | 39da39d3868144fd8103386ed31fcccb09c73164 /vignettes | |
| parent | d1fe83f2f1a9c0d775b0dc8f18301a8bbb454077 (diff) | |
A lot of working components of the new layout
Diffstat (limited to 'vignettes')
| -rw-r--r-- | vignettes/gmkin_manual.Rmd | 2 | ||||
| -rw-r--r-- | vignettes/gmkin_manual.html | 2 | ||||
| -rw-r--r-- | vignettes/gmkin_manual.md | 408 |
3 files changed, 410 insertions, 2 deletions
diff --git a/vignettes/gmkin_manual.Rmd b/vignettes/gmkin_manual.Rmd index dd1ae7f..7200b12 100644 --- a/vignettes/gmkin_manual.Rmd +++ b/vignettes/gmkin_manual.Rmd @@ -400,6 +400,6 @@ a fit has been run and confidence intervals were successfully calculated for the if the model was not overparameterised and no other problems occurred), the confidence intervals are graphically displayed as bars as shown below. - + <!-- vim: set foldmethod=syntax ts=2 sw=2 expandtab: --> diff --git a/vignettes/gmkin_manual.html b/vignettes/gmkin_manual.html index bff6a74..8ae6ef8 100644 --- a/vignettes/gmkin_manual.html +++ b/vignettes/gmkin_manual.html @@ -244,7 +244,7 @@ Model cost at call 37 : 371.2134 </code></pre> <h3>Confidence interval plots</h3> <p>Whenever a new fit has been configured or a run of a fit has been completed, the plotting area is updated with the abovementioned plot of the data and the current model solution.</p> <p>In addition, a confidence interval plot is shown below this conventional plot. In case a fit has been run and confidence intervals were successfully calculated for the fit (i.e. if the model was not overparameterised and no other problems occurred), the confidence intervals are graphically displayed as bars as shown below.</p> -<p><img src="data:image/png;base64,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" alt="conficence" /></p> +<p><img 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" alt="confidence" /></p> <!-- vim: set foldmethod=syntax ts=2 sw=2 expandtab: --> </div> </div> diff --git a/vignettes/gmkin_manual.md b/vignettes/gmkin_manual.md new file mode 100644 index 0000000..bab6770 --- /dev/null +++ b/vignettes/gmkin_manual.md @@ -0,0 +1,408 @@ +--- +title: "Manual for gmkin" +output: + html_document: + css: gmkin_manual.css + toc: true + theme: united +--- +<!-- +%\VignetteEngine{knitr::rmarkdown} +%\VignetteIndexEntry{Manual for gmkin} +--> + + +## Introduction + +The R add-on package gmkin provides a browser based graphical interface for +performing kinetic evaluations of degradation data using the mkin package. +While the use of gmkin should be largely self-explanatory, this manual may serve +as a functionality overview and reference. + +For system requirements and installation instructions, please refer to the +[gmkin homepage](http://kinfit.r-forge.r-project.org/gmkin_static) + +## Starting gmkin + +As gmkin is an R package, you need to start R and load the gmkin package before you can run gmkin. +This can be achieved by entering the command + + +```r +library(gmkin) +``` + +into the R console. This will also load the packages that gmkin depends on, +most notably gWidgetsWWW2 and mkin. Loading the package only has to be done +once after you have started R. + +Before you start gmkin, you should make sure that R is using the working +directory that you would like to keep your gmkin project file(s) in. If you use +the standard R application on windows, you can change the working directory +from the File menu. + +Once you are sure that the working directory is what you want it to be, gmkin +can be started by entering the R command + + +```r +gmkin() +``` + +This will cause the default browser to start up or, if it is already running, to +pop up and open a new tab for displaying the gmkin user interface. + +In the R console, you should see some messages, telling you if the local R help +server, which also serves the gmkin application, has been started, which port it is +using and that it is starting an app called gmkin. + +Finally, it should give a message like + + +```r +Model cost at call 1: 2388.077 +``` + +which means that the first kinetic evaluation has been configured for fitting. + +In the browser, you should see something like the screenshot below. + + + +The statusbar at the bottom of the gmkin window shows, among others, the +working directory that gmkin uses. + +Note that the project file management area described below can be minimized by clicking on +the arrows on the right hand side of its title bar. This may be helpful if the vertical +size of your browser window is restricted. + +## Project file management + +At startup, gmkin loads a project called "FOCUS\_2006\_gmkin" which is distributed +with the gmkin package. A gmkin project contains datasets, kinetic models for +fitting, and so-called fits, i.e. the results of fitting models to data. These +gmkin projects can be saved and restored using the project file management area in the +top left. + + + +If you would like to save these items for reference or for the purpose of continuing +your work at a later time, you can modify the project name and press the button below it. +The full name of the project file created and the working directory will be displayed +in the gmkin status bar. + +For restoring a previously saved project file, use the Browse button to locate +it, and the "Upload" button to load its contents into gmkin. + +## Studies + +The "Studies" area directly below the "Project file management" area can be expanded by clicking +on the arrows on the right hand side of its title bar. Studies in gmkin are +simply a numbered list of sources for the datasets in a project. You can edit the titles +directly by clicking on them. If you would like to add a new data source, use the "Add" +button above the table containing the list. If there are more than one studies in the list, +you can also remove them using the "Remove" button. + + + +Note that the user is responsible to keep the study list consistent with the numbers that are +used in the list of datasets described below. + +## Datasets and Models +The project loaded at the start of gmkin contains two datasets and four kinetic models. These +are listed to the left under the heading "Datasets and Models", together with a button for +setting up fits as shown below. + + + +For editing, adding or removing datasets or models, you need to double-click on an +entry in the respective list. + +For setting up a fit of a specific model to a specific dataset, the model and +the dataset should be selected by clicking on them. If they are compatible, clicking +the button "Configure fit for selected dataset and model" will set up the fit and +open the "Plotting and Fitting" tab to the right. + +## Dataset editor + +The dataset editor allows for editing datasets, entering new datasets, uploading +data from text files and deleting datasets. + + + +If you want to create (enter or load) a new dataset, it is wise to first edit +the list of data sources in the "Studies" area as described above. + +### Entering data directly + +For entering new data manually, click on "New dataset", enter a title and select +the study from which the dataset is taken. At this stage, you may already want +to press "Keep changes", so the dataset appears in the list of datasets. + +In order to generate a table suitable for entering the data, enter a comma separated +list of sampling times, optionally the time unit, and the number of replicate measurements +at each sampling time. Also, add a comma separated list of short names of the +relevant compounds in your dataset. A unit can be specified for the observed +values. An example of filling out the respective fields is shown below. + + + +Once everyting is filled out to your satisfaction, press the button "Generate empty grid +for kinetic data". In our example, this would result in the data grid shown below. You +can enter the observed data into the value column, as shown in the screenshot below. + + + +The column with title override serves to override data points from the original +datasets, without loosing the information which value was originally reported. + +If everything is OK, press "Keep changes" to save the dataset in the current +workspace. Note that you need to save the project file (see above) in order to +be able to use the dataset that you created in a future gmkin session. + +### Importing data from text files + +In case you want to work with a larger dataset that is already available as a computer +file e.g. in a spreadsheet application, you can export these data as a tab separated +or comma separated text file and import it using the "Browse" and "Upload" buttons in the +dataset editor. + +As an example, we can create a text file from one of the datasets shipped with +the mkin package using the following R command: + + +```r +write.table(schaefer07_complex_case, sep = ",", dec = ".", + row.names = FALSE, quote = FALSE, + file = "schaefer07.csv") +``` + +This produces a text file with comma separated values in the current working directory of R. + +Loading this text file into gmkin using the "Browse" and "Upload" buttons results in +an import configuration area like this, with the uploaded text file displayed to the left, +and the import options to the right. + + + +In the import configuration area, the following options can be specified. In the field +"Comment lines", the number of lines in the beginning of the file that should be ignored +can be specified. + +The checkbox on the next line should be checked if the first line of the file contains +the column names, i.e. the names of the observed variables when the data are in wide format. + +As "Separator", whitespace, semicolon or comma can be chosen. If whitespace is selected, +files in which the values are separated by a fixed or varying number of whitespace characters +should be read in correctly. As the tabulator counts as a whitespace character, this is +also the option to choose for tabulator separated values. + +As the "Decimal" separator, comma "," or period "." can be selected. + +In the next line, it can be specified if the data are in wide or in long format. +If in wide format, the only option left to specify is the title of the column containing +the sampling times. If the data is in long format, the column headings specifying the +columns containing the observed variables (default is "name"), the sampling times +(default is "time"), the observed values (default is "value") and, if present in the data, +the relative errors (default is "err") can be adapted. The default settings appearing if +the long format is selected are shown below. + + + +In our example we have data in the wide format, and after adapting the +"Separator" to a comma, we can press the button "Import using options specified +below", and the data should be imported. If successful, the data editor should +show the sampling times and the names of the observed variables, as well as the +imported data in a grid for further editing or specifying overrides. + +After editing the title of the dataset and selecting the correct study as +the source of the data, the dataset editor should look like shown below. + + + +If everything is OK, press "Keep changes" to save the dataset in the current +workspace. Again, you need to save the project file in order to be able to use +the dataset that you created in a future gmkin session. + +## Model editor + +The following screenshot shows the model editor for the model number 4 in +the list of models that are in the initial workspace. + + + +In the first line the name of the model can be edited. You can also specify "min" or +"max" for minimum or maximum use of formation fractions. Maximum use of formation +fractions means that the differential equations in the degradation model are formulated +using formation fractions. When you specify "min", then formation fractions are only used +for the parent compound when you use the FOMC, DFOP or the HS model for it. + +Pressing "Copy model" keeps the model name, so you should change it for the newly generated copy. +Pressing "Add observed variable" adds a line in the array of state variable specifications below. +The observed variables to be added are usually transformation products (usually termed metabolites), +but can also be the parent compound in a different compartment (e.g. "parent\_sediment"). + +Only observed variable names that occur in previously defined datasets can be selected. For any observed +variable other than the first one, only the SFO or the SFORB model can be selected. For each +observed variables, a comma separated list of target variables can be specified. In addition, a pathway +to the sink compartment can be selected. If too many observed variables have been added, complete lines +can be removed from the model definition by pressing the button "Remove observed variable". + +If the model definition is supposedly correct, press "Keep changes" to make it possible to select +it for fitting in the listing of models to the left. + +## Plotting and fitting + +If the dataset(s) to be used in a project are created, and suitable kinetic models have been defined, +kinetic evaluations can be configured by selecting one dataset and one model in the lists to the left, +and the pressing the button "Configure fit for selected dataset and model" below these lists. + +This opens the "Plotting and fitting" tab area to the right, consisting of a graphical window +showing the data points in the selected dataset and the model, evaluated with the initial parameters +defined by calling `mkinfit` without defining starting parameters. The value of the objective function +to be minimized for these default parameters can be seen in the R console, e.g. as + + +```r +Model cost at call 1: 15156.12 +``` + +for the example shown below, where the FOCUS example dataset D and the model SFO\_SFO were selected. + + + +### Parameters + +In the right hand area, initially the tab with the parameter list is displayed. While +name and type of the parameters should not be edited, their initial values can be edited +by clicking on a row. Also, it can be specified if the parameters should be fixed +in the optimisation process. + +If the initial values for the parameters were changed, the resulting model solution +can be visually checked by pressing the button "Show initial". This will update the +plot of the model and the data using the specified initial parameter values. + +If a similar model with a partially overlapping model definition has already be fitted, +initial values for parameters with the same name in both models can also be retrieved +from previous fits by selecting the fit and pressing the button "Get initials +from". This facilitates stepwise fitting of more complex degradation pathways. + +After the model has been successfully fitted by pressing the "Run" button, the optimised +parameter values are added to the parameter table. + +### Fit options + +The most important fit options of the `mkinfit` function can be set via the +"Fit option" tab shown below. If the "plot" checkbox is checked, an R graphics device +started via the R console shows the fitting progress, i.e. the change of the model +solution together with the data during the optimisation. + + + +The "solution\_type" can either be "auto", which means that the most effective solution +method is chosen for the model, in the order of "analytical" (for parent only degradation +data), "eigen" (for differential equation models with only linear terms, i.e. without +FOMC, DFOP or HS submodels) or "deSolve", which can handle all model definitions generated +by the `mkin` package. + +The parameters "atol" and "rtol" are only effective if the solution type is "deSolve". They +control the precision of the iterative numerical solution of the differential equation model. + +The checkboxes "transform\_rates" and "transform\_fractions" control if the parameters are fitted +as defined in the model, or if they are internally transformed during the fitting process in +order to improve the estimation of standard errors and confidence intervals which are based +on a linear approximation at the optimum found by the fitting algorithm. + +If fitting with transformed fractions leads to a suboptimal fit, doing a first +run without transforming fractions may help. A final run using the optimised +parameters from the previous run as starting values (see comment on "Get +initials from" above) can then be performed with transformed fractions. + +The dropdown box "weight" specifies if and how the observed values should be weighted +in the fitting process. If "manual" is chosen, the values in the "err" column of the +dataset are used, which are set to unity by default. Setting these to higher values +gives lower weight and vice versa. If "none" is chosen, observed +values are not weighted. Please refer to the documentation of the `modFit` function from +the `FME` package for the meaning of options "std" and "mean". + +The options "reweight.method", "reweight.tol" and "reweight.max.iter" enable the use of +iteratively reweighted least squares fitting, if the reweighting method is set to "obs". Please +refer to the `mkinfit` [documentation](http://kinfit.r-forge.r-project.org/mkin_static/mkinfit.html) +for more details. + +The drop down box "method.modFit" makes it possible to choose between the optimisation +algorithms "Port" (the default in mkin versions > 0.9-33, a local optimisation +algorithm using a model/trust region approach), "Marq" (the former default in +mkin, a Levenberg-Marquardt variant from the R package `minpack.lm`), +and "SANN" (the simulated annealing method - robust but inefficient and without +a convergence criterion). + +Finally, the maximum number of iterations for the optimisation can be adapted using the +"maxit.modFit" field. + +### Fitting the model + +In many cases the starting parameters and the fit options do not need to be modified +and the model fitting process can simply be started by pressing the "Run" button. +In the R console, the progressive reduction in the model cost can be monitored and will +be displayed like this: + + +```r +Model cost at call 1 : 15156.12 +Model cost at call 3 : 15156.12 +Model cost at call 7 : 14220.79 +Model cost at call 8 : 14220.79 +Model cost at call 11 : 14220.79 +Model cost at call 12 : 3349.268 +Model cost at call 15 : 3349.268 +Model cost at call 17 : 788.6367 +Model cost at call 18 : 788.6366 +Model cost at call 22 : 374.0575 +Model cost at call 23 : 374.0575 +Model cost at call 27 : 371.2135 +Model cost at call 28 : 371.2135 +Model cost at call 32 : 371.2134 +Model cost at call 36 : 371.2134 +Model cost at call 37 : 371.2134 +``` + +If plotting of the fitting progress was selecte in the "Fit options" tab, a +new separate graphics window should either pop up, or a graphics window previously +started for this purpose will be reused. + +### Summary + +Once a fit has successfully been performed by pressing the "Run" button, the summary +as displayed below can be accessed via the "Summary" tab. + + + +The complete summary can be saved into a text file by specifying a suitable file name +and pressing the button "Save summary". + +### Plot options + +In the tab "Plot options", the file format can be chosen, the legend can be +turned off, and the observed variables for which the data and the model fit +should be plotted can be selected as shown below. + + + +On systems running the Windows operating system, the windows metafile (wmf) format +can be additionally chosen. Chaning the file format for plotting will also change +the extension of the proposed filename for saving the plot. + +### Confidence interval plots + +Whenever a new fit has been configured or a run of a fit has been completed, the plotting +area is updated with the abovementioned plot of the data and the current model solution. + +In addition, a confidence interval plot is shown below this conventional plot. In case +a fit has been run and confidence intervals were successfully calculated for the fit (i.e. +if the model was not overparameterised and no other problems occurred), the +confidence intervals are graphically displayed as bars as shown below. + + + +<!-- vim: set foldmethod=syntax ts=2 sw=2 expandtab: --> |