Remove nlmixr interface for release of mkin 1.1.0

I am postponing my attempts to get the nlmixr interface to CRAN, given
some problems with nlmixr using R-devel under Windows, see
https://github.com/nlmixrdevelopment/nlmixr/issues/596
and
https://github.com/r-hub/rhub/issues/512,
which is fixed by the removal of nlmixr from the testsuite.

For the tests to be more platform independent, the biphasic mixed
effects models test dataset was defined in a way that fitting
should be more robust (less ill-defined).

1 files changed, 19 insertions, 19 deletions

diff --git a/docs/articles/FOCUS_L.html b/docs/articles/FOCUS_L.html
index 9efea93a..d7412a56 100644
--- a/docs/articles/FOCUS_L.html
+++ b/docs/articles/FOCUS_L.html
@@ -43,7 +43,7 @@
   <a href="../reference/index.html">Functions and data</a>
 </li>
 <li class="dropdown">
-  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">
+  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false">
     Articles
      
     <span class="caret"></span>
@@ -105,7 +105,7 @@
       <h1 data-toc-skip>Example evaluation of FOCUS Laboratory Data L1 to L3</h1>
                         <h4 data-toc-skip class="author">Johannes Ranke</h4>
             
-            <h4 data-toc-skip class="date">Last change 17 November 2016 (rebuilt 2022-03-02)</h4>
+            <h4 data-toc-skip class="date">Last change 17 November 2016 (rebuilt 2022-03-07)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/FOCUS_L.rmd" class="external-link"><code>vignettes/FOCUS_L.rmd</code></a></small>
       <div class="hidden name"><code>FOCUS_L.rmd</code></div>
@@ -133,8 +133,8 @@
 <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L1.SFO</span><span class="op">)</span></code></pre></div>
 <pre><code><span class="co">## mkin version used for fitting:    1.1.0 </span>
 <span class="co">## R version used for fitting:       4.1.2 </span>
-<span class="co">## Date of fit:     Wed Mar  2 13:44:22 2022 </span>
-<span class="co">## Date of summary: Wed Mar  2 13:44:22 2022 </span>
+<span class="co">## Date of fit:     Mon Mar  7 13:16:01 2022 </span>
+<span class="co">## Date of summary: Mon Mar  7 13:16:01 2022 </span>
 <span class="co">## </span>
 <span class="co">## Equations:</span>
 <span class="co">## d_parent/dt = - k_parent * parent</span>
@@ -239,15 +239,15 @@
 <span class="co">## doubtful</span></code></pre>
 <pre><code><span class="co">## mkin version used for fitting:    1.1.0 </span>
 <span class="co">## R version used for fitting:       4.1.2 </span>
-<span class="co">## Date of fit:     Wed Mar  2 13:44:22 2022 </span>
-<span class="co">## Date of summary: Wed Mar  2 13:44:22 2022 </span>
+<span class="co">## Date of fit:     Mon Mar  7 13:16:02 2022 </span>
+<span class="co">## Date of summary: Mon Mar  7 13:16:02 2022 </span>
 <span class="co">## </span>
 <span class="co">## Equations:</span>
 <span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span>
 <span class="co">## </span>
 <span class="co">## Model predictions using solution type analytical </span>
 <span class="co">## </span>
-<span class="co">## Fitted using 369 model solutions performed in 0.082 s</span>
+<span class="co">## Fitted using 369 model solutions performed in 0.081 s</span>
 <span class="co">## </span>
 <span class="co">## Error model: Constant variance </span>
 <span class="co">## </span>
@@ -351,8 +351,8 @@
 <code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L2.FOMC</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div>
 <pre><code><span class="co">## mkin version used for fitting:    1.1.0 </span>
 <span class="co">## R version used for fitting:       4.1.2 </span>
-<span class="co">## Date of fit:     Wed Mar  2 13:44:23 2022 </span>
-<span class="co">## Date of summary: Wed Mar  2 13:44:23 2022 </span>
+<span class="co">## Date of fit:     Mon Mar  7 13:16:03 2022 </span>
+<span class="co">## Date of summary: Mon Mar  7 13:16:03 2022 </span>
 <span class="co">## </span>
 <span class="co">## Equations:</span>
 <span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span>
@@ -432,8 +432,8 @@
 <code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L2.DFOP</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div>
 <pre><code><span class="co">## mkin version used for fitting:    1.1.0 </span>
 <span class="co">## R version used for fitting:       4.1.2 </span>
-<span class="co">## Date of fit:     Wed Mar  2 13:44:23 2022 </span>
-<span class="co">## Date of summary: Wed Mar  2 13:44:23 2022 </span>
+<span class="co">## Date of fit:     Mon Mar  7 13:16:03 2022 </span>
+<span class="co">## Date of summary: Mon Mar  7 13:16:03 2022 </span>
 <span class="co">## </span>
 <span class="co">## Equations:</span>
 <span class="co">## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span>
@@ -442,7 +442,7 @@
 <span class="co">## </span>
 <span class="co">## Model predictions using solution type analytical </span>
 <span class="co">## </span>
-<span class="co">## Fitted using 581 model solutions performed in 0.131 s</span>
+<span class="co">## Fitted using 581 model solutions performed in 0.132 s</span>
 <span class="co">## </span>
 <span class="co">## Error model: Constant variance </span>
 <span class="co">## </span>
@@ -538,8 +538,8 @@
 <code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div>
 <pre><code><span class="co">## mkin version used for fitting:    1.1.0 </span>
 <span class="co">## R version used for fitting:       4.1.2 </span>
-<span class="co">## Date of fit:     Wed Mar  2 13:44:24 2022 </span>
-<span class="co">## Date of summary: Wed Mar  2 13:44:24 2022 </span>
+<span class="co">## Date of fit:     Mon Mar  7 13:16:04 2022 </span>
+<span class="co">## Date of summary: Mon Mar  7 13:16:04 2022 </span>
 <span class="co">## </span>
 <span class="co">## Equations:</span>
 <span class="co">## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span>
@@ -548,7 +548,7 @@
 <span class="co">## </span>
 <span class="co">## Model predictions using solution type analytical </span>
 <span class="co">## </span>
-<span class="co">## Fitted using 376 model solutions performed in 0.079 s</span>
+<span class="co">## Fitted using 376 model solutions performed in 0.08 s</span>
 <span class="co">## </span>
 <span class="co">## Error model: Constant variance </span>
 <span class="co">## </span>
@@ -651,8 +651,8 @@
 <code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">[[</span><span class="st">"SFO"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div>
 <pre><code><span class="co">## mkin version used for fitting:    1.1.0 </span>
 <span class="co">## R version used for fitting:       4.1.2 </span>
-<span class="co">## Date of fit:     Wed Mar  2 13:44:25 2022 </span>
-<span class="co">## Date of summary: Wed Mar  2 13:44:25 2022 </span>
+<span class="co">## Date of fit:     Mon Mar  7 13:16:04 2022 </span>
+<span class="co">## Date of summary: Mon Mar  7 13:16:05 2022 </span>
 <span class="co">## </span>
 <span class="co">## Equations:</span>
 <span class="co">## d_parent/dt = - k_parent * parent</span>
@@ -716,8 +716,8 @@
 <code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">[[</span><span class="st">"FOMC"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div>
 <pre><code><span class="co">## mkin version used for fitting:    1.1.0 </span>
 <span class="co">## R version used for fitting:       4.1.2 </span>
-<span class="co">## Date of fit:     Wed Mar  2 13:44:25 2022 </span>
-<span class="co">## Date of summary: Wed Mar  2 13:44:25 2022 </span>
+<span class="co">## Date of fit:     Mon Mar  7 13:16:04 2022 </span>
+<span class="co">## Date of summary: Mon Mar  7 13:16:05 2022 </span>
 <span class="co">## </span>
 <span class="co">## Equations:</span>
 <span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span>