Fix solution type "deSolve" for a special caseHEADdev

The special case occurs if not observed data for time zero
are available. Fixes #16. Write NEWS and update docs.

A lot of html was regenerated, because I had checked out
the main branch in between, which made pkgdown believe that
I have changed the help files.

15 files changed, 113 insertions, 117 deletions

diff --git a/docs/dev/articles/FOCUS_D.html b/docs/dev/articles/FOCUS_D.html
index a21ed6d4..d9b783e7 100644
--- a/docs/dev/articles/FOCUS_D.html
+++ b/docs/dev/articles/FOCUS_D.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change 31 January 2019
-(rebuilt 2025-02-14)</h4>
+(rebuilt 2025-02-16)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/FOCUS_D.rmd" class="external-link"><code>vignettes/FOCUS_D.rmd</code></a></small>
       <div class="d-none name"><code>FOCUS_D.rmd</code></div>
@@ -188,8 +188,8 @@ the <code>mkinparplot</code> function.</p>
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## mkin version used for fitting:    1.2.10 </span></span>
 <span><span class="co">## R version used for fitting:       4.4.2 </span></span>
-<span><span class="co">## Date of fit:     Fri Feb 14 08:59:09 2025 </span></span>
-<span><span class="co">## Date of summary: Fri Feb 14 08:59:09 2025 </span></span>
+<span><span class="co">## Date of fit:     Sun Feb 16 17:04:33 2025 </span></span>
+<span><span class="co">## Date of summary: Sun Feb 16 17:04:33 2025 </span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Equations:</span></span>
 <span><span class="co">## d_parent/dt = - k_parent * parent</span></span>
@@ -197,7 +197,7 @@ the <code>mkinparplot</code> function.</p>
 <span><span class="co">## </span></span>
 <span><span class="co">## Model predictions using solution type analytical </span></span>
 <span><span class="co">## </span></span>
-<span><span class="co">## Fitted using 401 model solutions performed in 0.053 s</span></span>
+<span><span class="co">## Fitted using 401 model solutions performed in 0.051 s</span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Error model: Constant variance </span></span>
 <span><span class="co">## </span></span>
diff --git a/docs/dev/articles/FOCUS_L.html b/docs/dev/articles/FOCUS_L.html
index badf4822..fe1e7312 100644
--- a/docs/dev/articles/FOCUS_L.html
+++ b/docs/dev/articles/FOCUS_L.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change 18 May 2023
-(rebuilt 2025-02-14)</h4>
+(rebuilt 2025-02-16)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/FOCUS_L.rmd" class="external-link"><code>vignettes/FOCUS_L.rmd</code></a></small>
       <div class="d-none name"><code>FOCUS_L.rmd</code></div>
@@ -120,15 +120,15 @@ report.</p>
 <span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L1.SFO</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## mkin version used for fitting:    1.2.10 </span></span>
 <span><span class="co">## R version used for fitting:       4.4.2 </span></span>
-<span><span class="co">## Date of fit:     Fri Feb 14 08:59:11 2025 </span></span>
-<span><span class="co">## Date of summary: Fri Feb 14 08:59:11 2025 </span></span>
+<span><span class="co">## Date of fit:     Sun Feb 16 17:04:35 2025 </span></span>
+<span><span class="co">## Date of summary: Sun Feb 16 17:04:35 2025 </span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Equations:</span></span>
 <span><span class="co">## d_parent/dt = - k_parent * parent</span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Model predictions using solution type analytical </span></span>
 <span><span class="co">## </span></span>
-<span><span class="co">## Fitted using 133 model solutions performed in 0.01 s</span></span>
+<span><span class="co">## Fitted using 133 model solutions performed in 0.011 s</span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Error model: Constant variance </span></span>
 <span><span class="co">## </span></span>
@@ -228,8 +228,8 @@ error level is checked.</p>
 <span><span class="co">## non-finite result may be dubious</span></span></code></pre>
 <pre><code><span><span class="co">## mkin version used for fitting:    1.2.10 </span></span>
 <span><span class="co">## R version used for fitting:       4.4.2 </span></span>
-<span><span class="co">## Date of fit:     Fri Feb 14 08:59:11 2025 </span></span>
-<span><span class="co">## Date of summary: Fri Feb 14 08:59:11 2025 </span></span>
+<span><span class="co">## Date of fit:     Sun Feb 16 17:04:35 2025 </span></span>
+<span><span class="co">## Date of summary: Sun Feb 16 17:04:35 2025 </span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Equations:</span></span>
 <span><span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span></span>
@@ -386,8 +386,8 @@ error level is checked.</p>
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L2.FOMC</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## mkin version used for fitting:    1.2.10 </span></span>
 <span><span class="co">## R version used for fitting:       4.4.2 </span></span>
-<span><span class="co">## Date of fit:     Fri Feb 14 08:59:12 2025 </span></span>
-<span><span class="co">## Date of summary: Fri Feb 14 08:59:12 2025 </span></span>
+<span><span class="co">## Date of fit:     Sun Feb 16 17:04:35 2025 </span></span>
+<span><span class="co">## Date of summary: Sun Feb 16 17:04:35 2025 </span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Equations:</span></span>
 <span><span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span></span>
@@ -473,8 +473,8 @@ error level.</p>
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L2.DFOP</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## mkin version used for fitting:    1.2.10 </span></span>
 <span><span class="co">## R version used for fitting:       4.4.2 </span></span>
-<span><span class="co">## Date of fit:     Fri Feb 14 08:59:12 2025 </span></span>
-<span><span class="co">## Date of summary: Fri Feb 14 08:59:12 2025 </span></span>
+<span><span class="co">## Date of fit:     Sun Feb 16 17:04:36 2025 </span></span>
+<span><span class="co">## Date of summary: Sun Feb 16 17:04:36 2025 </span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Equations:</span></span>
 <span><span class="co">## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span></span>
@@ -596,8 +596,8 @@ summary and plot functions working on mkinfit objects.</p>
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## mkin version used for fitting:    1.2.10 </span></span>
 <span><span class="co">## R version used for fitting:       4.4.2 </span></span>
-<span><span class="co">## Date of fit:     Fri Feb 14 08:59:12 2025 </span></span>
-<span><span class="co">## Date of summary: Fri Feb 14 08:59:12 2025 </span></span>
+<span><span class="co">## Date of fit:     Sun Feb 16 17:04:36 2025 </span></span>
+<span><span class="co">## Date of summary: Sun Feb 16 17:04:36 2025 </span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Equations:</span></span>
 <span><span class="co">## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span></span>
@@ -726,8 +726,8 @@ difference appears negligible.</p>
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">[[</span><span class="st">"SFO"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## mkin version used for fitting:    1.2.10 </span></span>
 <span><span class="co">## R version used for fitting:       4.4.2 </span></span>
-<span><span class="co">## Date of fit:     Fri Feb 14 08:59:13 2025 </span></span>
-<span><span class="co">## Date of summary: Fri Feb 14 08:59:13 2025 </span></span>
+<span><span class="co">## Date of fit:     Sun Feb 16 17:04:36 2025 </span></span>
+<span><span class="co">## Date of summary: Sun Feb 16 17:04:37 2025 </span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Equations:</span></span>
 <span><span class="co">## d_parent/dt = - k_parent * parent</span></span>
@@ -791,15 +791,15 @@ difference appears negligible.</p>
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">[[</span><span class="st">"FOMC"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## mkin version used for fitting:    1.2.10 </span></span>
 <span><span class="co">## R version used for fitting:       4.4.2 </span></span>
-<span><span class="co">## Date of fit:     Fri Feb 14 08:59:13 2025 </span></span>
-<span><span class="co">## Date of summary: Fri Feb 14 08:59:13 2025 </span></span>
+<span><span class="co">## Date of fit:     Sun Feb 16 17:04:36 2025 </span></span>
+<span><span class="co">## Date of summary: Sun Feb 16 17:04:37 2025 </span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Equations:</span></span>
 <span><span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Model predictions using solution type analytical </span></span>
 <span><span class="co">## </span></span>
-<span><span class="co">## Fitted using 224 model solutions performed in 0.013 s</span></span>
+<span><span class="co">## Fitted using 224 model solutions performed in 0.014 s</span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Error model: Constant variance </span></span>
 <span><span class="co">## </span></span>
diff --git a/docs/dev/articles/mkin.html b/docs/dev/articles/mkin.html
index 30b2182f..a1d4fd3c 100644
--- a/docs/dev/articles/mkin.html
+++ b/docs/dev/articles/mkin.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change 18 May 2023
-(rebuilt 2025-02-14)</h4>
+(rebuilt 2025-02-16)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/mkin.rmd" class="external-link"><code>vignettes/mkin.rmd</code></a></small>
       <div class="d-none name"><code>mkin.rmd</code></div>
diff --git a/docs/dev/articles/prebuilt/2022_cyan_pathway.html b/docs/dev/articles/prebuilt/2022_cyan_pathway.html
index b93e5e7e..0a37915d 100644
--- a/docs/dev/articles/prebuilt/2022_cyan_pathway.html
+++ b/docs/dev/articles/prebuilt/2022_cyan_pathway.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change on 13 February
-2023, last compiled on 14 Februar 2025</h4>
+2023, last compiled on 16 Februar 2025</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/prebuilt/2022_cyan_pathway.rmd" class="external-link"><code>vignettes/prebuilt/2022_cyan_pathway.rmd</code></a></small>
       <div class="d-none name"><code>2022_cyan_pathway.rmd</code></div>
@@ -2254,7 +2254,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:42:26 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan/dt = - k_cyan * cyan
@@ -2382,7 +2382,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:42:06 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan/dt = - k_cyan * cyan
@@ -2512,7 +2512,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:42:57 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan
@@ -2657,7 +2657,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:42:50 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan
@@ -2795,7 +2795,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:43:33 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -2941,7 +2941,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:46:07 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -3087,7 +3087,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:43:36 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -3252,7 +3252,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:46:14 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -3417,7 +3417,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:43:42 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan/dt = - ifelse(time &lt;= tb, k1, k2) * cyan
@@ -3563,7 +3563,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:54:36 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan
@@ -3729,7 +3729,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:55:32 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -3920,7 +3920,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:57:56 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -4111,7 +4111,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:55:26 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -4307,7 +4307,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 07:58:06 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:40 2025 
 
 Equations:
 d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -4508,7 +4508,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 08:11:01 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:41 2025 
 
 Equations:
 d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan
@@ -4651,7 +4651,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 08:12:27 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:41 2025 
 
 Equations:
 d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -4817,7 +4817,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 08:12:54 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:41 2025 
 
 Equations:
 d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -4983,7 +4983,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 08:12:32 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:41 2025 
 
 Equations:
 d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -5154,7 +5154,7 @@ saemix version used for fitting:      3.3
 mkin version used for pre-fitting:  1.2.10 
 R version used for fitting:         4.4.2 
 Date of fit:     Fri Feb 14 08:12:36 2025 
-Date of summary: Fri Feb 14 08:12:55 2025 
+Date of summary: Sun Feb 16 17:03:41 2025 
 
 Equations:
 d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -5345,25 +5345,22 @@ attached base packages:
 [8] base     
 
 other attached packages:
-[1] rmarkdown_2.29  nvimcom_0.9-167 saemix_3.3      npde_3.5       
-[5] knitr_1.49      mkin_1.2.10    
+[1] saemix_3.3  npde_3.5    knitr_1.49  mkin_1.2.10
 
 loaded via a namespace (and not attached):
- [1] sass_0.4.9        utf8_1.2.4        generics_0.1.3    lattice_0.22-6   
- [5] digest_0.6.37     magrittr_2.0.3    evaluate_1.0.1    grid_4.4.2       
- [9] fastmap_1.2.0     cellranger_1.1.0  jsonlite_1.8.9    processx_3.8.4   
-[13] pkgbuild_1.4.5    deSolve_1.40      mclust_6.1.1      ps_1.8.1         
-[17] gridExtra_2.3     fansi_1.0.6       scales_1.3.0      codetools_0.2-20 
-[21] textshaping_0.4.1 jquerylib_0.1.4   cli_3.6.3         rlang_1.1.4      
-[25] munsell_0.5.1     cachem_1.1.0      yaml_2.3.10       inline_0.3.20    
-[29] tools_4.4.2       dplyr_1.1.4       colorspace_2.1-1  ggplot2_3.5.1    
-[33] vctrs_0.6.5       R6_2.5.1          zoo_1.8-12        lifecycle_1.0.4  
-[37] fs_1.6.5          htmlwidgets_1.6.4 MASS_7.3-61       ragg_1.3.3       
-[41] callr_3.7.6       pkgconfig_2.0.3   desc_1.4.3        pkgdown_2.1.1    
-[45] pillar_1.9.0      bslib_0.8.0       gtable_0.3.6      glue_1.8.0       
-[49] systemfonts_1.1.0 xfun_0.49         tibble_3.2.1      lmtest_0.9-40    
-[53] tidyselect_1.2.1  htmltools_0.5.8.1 nlme_3.1-166      compiler_4.4.2   
-[57] readxl_1.4.3     </code></pre>
+ [1] gtable_0.3.6      jsonlite_1.8.9    dplyr_1.1.4       compiler_4.4.2   
+ [5] tidyselect_1.2.1  gridExtra_2.3     jquerylib_0.1.4   systemfonts_1.1.0
+ [9] scales_1.3.0      textshaping_0.4.1 yaml_2.3.10       fastmap_1.2.0    
+[13] lattice_0.22-6    ggplot2_3.5.1     R6_2.5.1          generics_0.1.3   
+[17] lmtest_0.9-40     MASS_7.3-61       htmlwidgets_1.6.4 tibble_3.2.1     
+[21] desc_1.4.3        munsell_0.5.1     bslib_0.8.0       pillar_1.9.0     
+[25] rlang_1.1.4       utf8_1.2.4        inline_0.3.20     cachem_1.1.0     
+[29] xfun_0.49         fs_1.6.5          sass_0.4.9        cli_3.6.3        
+[33] pkgdown_2.1.1     magrittr_2.0.3    digest_0.6.37     grid_4.4.2       
+[37] mclust_6.1.1      lifecycle_1.0.4   nlme_3.1-166      vctrs_0.6.5      
+[41] evaluate_1.0.1    glue_1.8.0        ragg_1.3.3        zoo_1.8-12       
+[45] fansi_1.0.6       colorspace_2.1-1  rmarkdown_2.29    pkgconfig_2.0.3  
+[49] tools_4.4.2       htmltools_0.5.8.1</code></pre>
 </div>
 <div class="section level3">
 <h3 id="hardware-info">Hardware info<a class="anchor" aria-label="anchor" href="#hardware-info"></a>
diff --git a/docs/dev/articles/prebuilt/2022_dmta_parent.html b/docs/dev/articles/prebuilt/2022_dmta_parent.html
index d900cf00..e4943574 100644
--- a/docs/dev/articles/prebuilt/2022_dmta_parent.html
+++ b/docs/dev/articles/prebuilt/2022_dmta_parent.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change on 5 January
-2023, last compiled on 14 Februar 2025</h4>
+2023, last compiled on 16 Februar 2025</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/prebuilt/2022_dmta_parent.rmd" class="external-link"><code>vignettes/prebuilt/2022_dmta_parent.rmd</code></a></small>
       <div class="d-none name"><code>2022_dmta_parent.rmd</code></div>
diff --git a/docs/dev/articles/prebuilt/2022_dmta_pathway.html b/docs/dev/articles/prebuilt/2022_dmta_pathway.html
index 92440f1f..f7386a47 100644
--- a/docs/dev/articles/prebuilt/2022_dmta_pathway.html
+++ b/docs/dev/articles/prebuilt/2022_dmta_pathway.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change on 20 April 2023,
-last compiled on 14 Februar 2025</h4>
+last compiled on 16 Februar 2025</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/prebuilt/2022_dmta_pathway.rmd" class="external-link"><code>vignettes/prebuilt/2022_dmta_pathway.rmd</code></a></small>
       <div class="d-none name"><code>2022_dmta_pathway.rmd</code></div>
diff --git a/docs/dev/articles/prebuilt/2023_mesotrione_parent.html b/docs/dev/articles/prebuilt/2023_mesotrione_parent.html
index 86c7c2dd..501639b6 100644
--- a/docs/dev/articles/prebuilt/2023_mesotrione_parent.html
+++ b/docs/dev/articles/prebuilt/2023_mesotrione_parent.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change on 4 August 2023,
-last compiled on 14 Februar 2025</h4>
+last compiled on 16 Februar 2025</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/prebuilt/2023_mesotrione_parent.rmd" class="external-link"><code>vignettes/prebuilt/2023_mesotrione_parent.rmd</code></a></small>
       <div class="d-none name"><code>2023_mesotrione_parent.rmd</code></div>
@@ -2450,23 +2450,22 @@ attached base packages:
 [8] base     
 
 other attached packages:
-[1] rmarkdown_2.29  nvimcom_0.9-167 saemix_3.3      npde_3.5       
-[5] knitr_1.49      mkin_1.2.10    
+[1] saemix_3.3  npde_3.5    knitr_1.49  mkin_1.2.10
 
 loaded via a namespace (and not attached):
- [1] sass_0.4.9        utf8_1.2.4        generics_0.1.3    lattice_0.22-6   
- [5] digest_0.6.37     magrittr_2.0.3    evaluate_1.0.1    grid_4.4.2       
- [9] fastmap_1.2.0     cellranger_1.1.0  jsonlite_1.8.9    mclust_6.1.1     
-[13] gridExtra_2.3     fansi_1.0.6       scales_1.3.0      codetools_0.2-20 
-[17] textshaping_0.4.1 jquerylib_0.1.4   cli_3.6.3         rlang_1.1.4      
-[21] munsell_0.5.1     cachem_1.1.0      yaml_2.3.10       tools_4.4.2      
-[25] dplyr_1.1.4       colorspace_2.1-1  ggplot2_3.5.1     vctrs_0.6.5      
-[29] R6_2.5.1          zoo_1.8-12        lifecycle_1.0.4   fs_1.6.5         
-[33] htmlwidgets_1.6.4 MASS_7.3-61       ragg_1.3.3        pkgconfig_2.0.3  
-[37] desc_1.4.3        pkgdown_2.1.1     pillar_1.9.0      bslib_0.8.0      
-[41] gtable_0.3.6      glue_1.8.0        systemfonts_1.1.0 xfun_0.49        
-[45] tibble_3.2.1      lmtest_0.9-40     tidyselect_1.2.1  htmltools_0.5.8.1
-[49] nlme_3.1-166      compiler_4.4.2    readxl_1.4.3     </code></pre>
+ [1] gtable_0.3.6      jsonlite_1.8.9    dplyr_1.1.4       compiler_4.4.2   
+ [5] tidyselect_1.2.1  gridExtra_2.3     jquerylib_0.1.4   systemfonts_1.1.0
+ [9] scales_1.3.0      textshaping_0.4.1 yaml_2.3.10       fastmap_1.2.0    
+[13] lattice_0.22-6    ggplot2_3.5.1     R6_2.5.1          generics_0.1.3   
+[17] lmtest_0.9-40     MASS_7.3-61       htmlwidgets_1.6.4 tibble_3.2.1     
+[21] desc_1.4.3        munsell_0.5.1     bslib_0.8.0       pillar_1.9.0     
+[25] rlang_1.1.4       utf8_1.2.4        cachem_1.1.0      xfun_0.49        
+[29] fs_1.6.5          sass_0.4.9        cli_3.6.3         pkgdown_2.1.1    
+[33] magrittr_2.0.3    digest_0.6.37     grid_4.4.2        mclust_6.1.1     
+[37] lifecycle_1.0.4   nlme_3.1-166      vctrs_0.6.5       evaluate_1.0.1   
+[41] glue_1.8.0        ragg_1.3.3        zoo_1.8-12        fansi_1.0.6      
+[45] colorspace_2.1-1  rmarkdown_2.29    pkgconfig_2.0.3   tools_4.4.2      
+[49] htmltools_0.5.8.1</code></pre>
 </div>
 <div class="section level3">
 <h3 id="hardware-info">Hardware info<a class="anchor" aria-label="anchor" href="#hardware-info"></a>
diff --git a/docs/dev/articles/twa.html b/docs/dev/articles/twa.html
index 1dea5c51..3118a862 100644
--- a/docs/dev/articles/twa.html
+++ b/docs/dev/articles/twa.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change 18 September 2019
-(rebuilt 2025-02-14)</h4>
+(rebuilt 2025-02-16)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/twa.rmd" class="external-link"><code>vignettes/twa.rmd</code></a></small>
       <div class="d-none name"><code>twa.rmd</code></div>
diff --git a/docs/dev/articles/web_only/FOCUS_Z.html b/docs/dev/articles/web_only/FOCUS_Z.html
index 40ce9e01..9db2cf7e 100644
--- a/docs/dev/articles/web_only/FOCUS_Z.html
+++ b/docs/dev/articles/web_only/FOCUS_Z.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change 16 January 2018
-(rebuilt 2025-02-14)</h4>
+(rebuilt 2025-02-16)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/FOCUS_Z.rmd" class="external-link"><code>vignettes/web_only/FOCUS_Z.rmd</code></a></small>
       <div class="d-none name"><code>FOCUS_Z.rmd</code></div>
diff --git a/docs/dev/articles/web_only/NAFTA_examples.html b/docs/dev/articles/web_only/NAFTA_examples.html
index 6bf39b2c..54c45b3e 100644
--- a/docs/dev/articles/web_only/NAFTA_examples.html
+++ b/docs/dev/articles/web_only/NAFTA_examples.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">26 February 2019 (rebuilt
-2025-02-14)</h4>
+2025-02-16)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/NAFTA_examples.rmd" class="external-link"><code>vignettes/web_only/NAFTA_examples.rmd</code></a></small>
       <div class="d-none name"><code>NAFTA_examples.rmd</code></div>
diff --git a/docs/dev/articles/web_only/benchmarks.html b/docs/dev/articles/web_only/benchmarks.html
index bd6a443a..bb5647d3 100644
--- a/docs/dev/articles/web_only/benchmarks.html
+++ b/docs/dev/articles/web_only/benchmarks.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change 17 February 2023
-(rebuilt 2025-02-14)</h4>
+(rebuilt 2025-02-16)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/benchmarks.rmd" class="external-link"><code>vignettes/web_only/benchmarks.rmd</code></a></small>
       <div class="d-none name"><code>benchmarks.rmd</code></div>
@@ -428,8 +428,8 @@ models fitted to two datasets, i.e. eight fits for each test.</p>
 <td align="left">Ryzen 9 7950X</td>
 <td align="left">4.4.2</td>
 <td align="left">1.2.10</td>
-<td align="right">1.371</td>
-<td align="right">1.980</td>
+<td align="right">1.407</td>
+<td align="right">1.990</td>
 </tr>
 </tbody>
 </table>
@@ -717,9 +717,9 @@ for each test.</p>
 <td align="left">Ryzen 9 7950X</td>
 <td align="left">4.4.2</td>
 <td align="left">1.2.10</td>
-<td align="right">0.762</td>
-<td align="right">2.179</td>
-<td align="right">1.131</td>
+<td align="right">0.775</td>
+<td align="right">2.199</td>
+<td align="right">1.161</td>
 </tr>
 </tbody>
 </table>
@@ -1097,12 +1097,12 @@ dataset, i.e. one fit for each test.</p>
 <td align="left">Ryzen 9 7950X</td>
 <td align="left">4.4.2</td>
 <td align="left">1.2.10</td>
-<td align="right">0.426</td>
-<td align="right">0.533</td>
-<td align="right">0.565</td>
-<td align="right">1.296</td>
-<td align="right">0.728</td>
-<td align="right">0.978</td>
+<td align="right">0.433</td>
+<td align="right">0.541</td>
+<td align="right">0.576</td>
+<td align="right">1.307</td>
+<td align="right">0.744</td>
+<td align="right">0.988</td>
 </tr>
 </tbody>
 </table>
diff --git a/docs/dev/articles/web_only/compiled_models.html b/docs/dev/articles/web_only/compiled_models.html
index 113f7b67..a88a19ee 100644
--- a/docs/dev/articles/web_only/compiled_models.html
+++ b/docs/dev/articles/web_only/compiled_models.html
@@ -84,7 +84,7 @@
                         <h4 data-toc-skip class="author">Johannes
 Ranke</h4>
             
-            <h4 data-toc-skip class="date">2025-02-14</h4>
+            <h4 data-toc-skip class="date">2025-02-16</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/compiled_models.rmd" class="external-link"><code>vignettes/web_only/compiled_models.rmd</code></a></small>
       <div class="d-none name"><code>compiled_models.rmd</code></div>
@@ -162,10 +162,10 @@ solution is also implemented, which is included in the tests below.</p>
 <span>  <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="st">"R package rbenchmark is not available"</span><span class="op">)</span></span>
 <span><span class="op">}</span></span></code></pre></div>
 <pre><code><span><span class="co">##                    test replications relative elapsed</span></span>
-<span><span class="co">## 4            analytical            1    1.000   0.102</span></span>
-<span><span class="co">## 3     deSolve, compiled            1    1.324   0.135</span></span>
-<span><span class="co">## 2      Eigenvalue based            1    1.706   0.174</span></span>
-<span><span class="co">## 1 deSolve, not compiled            1   22.627   2.308</span></span></code></pre>
+<span><span class="co">## 4            analytical            1    1.000   0.115</span></span>
+<span><span class="co">## 3     deSolve, compiled            1    1.217   0.140</span></span>
+<span><span class="co">## 2      Eigenvalue based            1    1.652   0.190</span></span>
+<span><span class="co">## 1 deSolve, not compiled            1   20.522   2.360</span></span></code></pre>
 <p>We see that using the compiled model is by more than a factor of 10
 faster than using deSolve without compiled code.</p>
 </div>
@@ -196,8 +196,8 @@ compiled code is available.</p>
 <span><span class="op">}</span></span></code></pre></div>
 <pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre>
 <pre><code><span><span class="co">##                    test replications relative elapsed</span></span>
-<span><span class="co">## 2     deSolve, compiled            1    1.000   0.170</span></span>
-<span><span class="co">## 1 deSolve, not compiled            1   23.865   4.057</span></span></code></pre>
+<span><span class="co">## 2     deSolve, compiled            1    1.000   0.180</span></span>
+<span><span class="co">## 1 deSolve, not compiled            1   23.656   4.258</span></span></code></pre>
 <p>Here we get a performance benefit of a factor of 24 using the version
 of the differential equation model compiled from C code!</p>
 <p>This vignette was built with mkin 1.2.10 on</p>
diff --git a/docs/dev/articles/web_only/dimethenamid_2018.html b/docs/dev/articles/web_only/dimethenamid_2018.html
index 572f253d..0bbf0b73 100644
--- a/docs/dev/articles/web_only/dimethenamid_2018.html
+++ b/docs/dev/articles/web_only/dimethenamid_2018.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change 1 July 2022,
-built on 14 Feb 2025</h4>
+built on 16 Feb 2025</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/dimethenamid_2018.rmd" class="external-link"><code>vignettes/web_only/dimethenamid_2018.rmd</code></a></small>
       <div class="d-none name"><code>dimethenamid_2018.rmd</code></div>
@@ -586,7 +586,7 @@ attached base packages:
 [1] stats     graphics  grDevices utils     datasets  methods   base     
 
 other attached packages:
-[1] saemix_3.3   npde_3.5     nlme_3.1-166 mkin_1.2.10  knitr_1.49  
+[1] nlme_3.1-166 mkin_1.2.10  knitr_1.49  
 
 loaded via a namespace (and not attached):
  [1] gtable_0.3.6      jsonlite_1.8.9    dplyr_1.1.4       compiler_4.4.2   
@@ -598,10 +598,10 @@ loaded via a namespace (and not attached):
 [25] pillar_1.9.0      rlang_1.1.4       utf8_1.2.4        cachem_1.1.0     
 [29] xfun_0.49         fs_1.6.5          sass_0.4.9        cli_3.6.3        
 [33] pkgdown_2.1.1     magrittr_2.0.3    digest_0.6.37     grid_4.4.2       
-[37] mclust_6.1.1      lifecycle_1.0.4   vctrs_0.6.5       evaluate_1.0.1   
-[41] glue_1.8.0        codetools_0.2-20  ragg_1.3.3        zoo_1.8-12       
-[45] fansi_1.0.6       colorspace_2.1-1  rmarkdown_2.29    pkgconfig_2.0.3  
-[49] tools_4.4.2       htmltools_0.5.8.1</code></pre>
+[37] npde_3.5          mclust_6.1.1      lifecycle_1.0.4   vctrs_0.6.5      
+[41] evaluate_1.0.1    glue_1.8.0        ragg_1.3.3        zoo_1.8-12       
+[45] saemix_3.3        fansi_1.0.6       colorspace_2.1-1  rmarkdown_2.29   
+[49] pkgconfig_2.0.3   tools_4.4.2       htmltools_0.5.8.1</code></pre>
 </div>
 <div class="section level2">
 <h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a>
diff --git a/docs/dev/articles/web_only/multistart.html b/docs/dev/articles/web_only/multistart.html
index 83073979..39bb2947 100644
--- a/docs/dev/articles/web_only/multistart.html
+++ b/docs/dev/articles/web_only/multistart.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change 20 April 2023
-(rebuilt 2025-02-14)</h4>
+(rebuilt 2025-02-16)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/multistart.rmd" class="external-link"><code>vignettes/web_only/multistart.rmd</code></a></small>
       <div class="d-none name"><code>multistart.rmd</code></div>
diff --git a/docs/dev/articles/web_only/saem_benchmarks.html b/docs/dev/articles/web_only/saem_benchmarks.html
index d4cd0d6f..b76384da 100644
--- a/docs/dev/articles/web_only/saem_benchmarks.html
+++ b/docs/dev/articles/web_only/saem_benchmarks.html
@@ -85,7 +85,7 @@
 Ranke</h4>
             
             <h4 data-toc-skip class="date">Last change 17 February 2023
-(rebuilt 2025-02-14)</h4>
+(rebuilt 2025-02-16)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/saem_benchmarks.rmd" class="external-link"><code>vignettes/web_only/saem_benchmarks.rmd</code></a></small>
       <div class="d-none name"><code>saem_benchmarks.rmd</code></div>
@@ -408,9 +408,9 @@ systems. All trademarks belong to their respective owners.</p>
 <td align="left">1.2.10</td>
 <td align="left">3.3</td>
 <td align="right">1.115</td>
-<td align="right">2.277</td>
-<td align="right">1.945</td>
-<td align="right">2.134</td>
+<td align="right">2.263</td>
+<td align="right">1.991</td>
+<td align="right">2.193</td>
 </tr>
 </tbody>
 </table>
@@ -542,10 +542,10 @@ systems. All trademarks belong to their respective owners.</p>
 <td align="left">Linux</td>
 <td align="left">1.2.10</td>
 <td align="left">3.3</td>
-<td align="right">2.372</td>
-<td align="right">3.137</td>
-<td align="right">3.100</td>
-<td align="right">3.281</td>
+<td align="right">2.380</td>
+<td align="right">3.147</td>
+<td align="right">3.131</td>
+<td align="right">3.331</td>
 </tr>
 </tbody>
 </table>
@@ -657,8 +657,8 @@ systems. All trademarks belong to their respective owners.</p>
 <td align="left">Linux</td>
 <td align="left">1.2.10</td>
 <td align="left">3.3</td>
-<td align="right">11.590</td>
-<td align="right">279.782</td>
+<td align="right">11.581</td>
+<td align="right">296.184</td>
 </tr>
 </tbody>
 </table>
@@ -758,7 +758,7 @@ systems. All trademarks belong to their respective owners.</p>
 <td align="left">Linux</td>
 <td align="left">1.2.10</td>
 <td align="left">3.3</td>
-<td align="right">469.036</td>
+<td align="right">486.856</td>
 </tr>
 </tbody>
 </table>