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authorJohannes Ranke <jranke@uni-bremen.de>2022-03-01 10:42:56 +0100
committerJohannes Ranke <jranke@uni-bremen.de>2022-03-01 10:42:56 +0100
commitc013e35de82825786a12fa98a202219dd241257e (patch)
treed0bf144328f1a43b5cd5b5b33ed319829c8eab9d /print_nlmixr_saem_biphasic.txt
parent1d581d24bc85402770a195b44e453a1449597faf (diff)
Some more tests for nlmixr.mmkin
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+Kinetic nonlinear mixed-effects model fit by saem using nlmixr
+Structural model:
+d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
+ time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
+ * parent
+d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)
+ * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *
+ exp(-k2 * time))) * parent - k_m1 * m1
+
+Data:
+507 observations of 2 variable(s) grouped in 15 datasets
+
+Likelihood:
+ AIC BIC logLik
+ 2510 2569 -1241
+
+Fitted parameters:
+ Est. SE %RSE Back-transformed(95%CI) BSV(CV% or SD)
+parent_0 100 0.444 0.442 100 (99.6, 101) 0.461
+log_k_m1 -5.36 0.0804 1.5 0.00472 (0.00403, 0.00552) 21.5
+f_parent_qlogis -0.0909 0.0868 95.5 0.477 (0.435, 0.52) 0.308
+log_k1 -2.78 0.0977 3.51 0.0618 (0.0511, 0.0749) 30.1
+log_k2 -4.51 0.08 1.77 0.011 (0.00941, 0.0129) 16.6
+g_qlogis -0.121 0.17 141 0.47 (0.388, 0.553) 0.373
+sigma_parent 3.72 3.72
+sigma_m1 1.44 1.44
+ Shrink(SD)%
+parent_0 69.2%>
+log_k_m1 19.6%<
+f_parent_qlogis -0.136%>
+log_k1 6.71%<
+log_k2 23.7%=
+g_qlogis 19.5%<
+sigma_parent
+sigma_m1

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