diff options
Diffstat (limited to 'R/parhist.R')
-rw-r--r-- | R/parhist.R | 52 |
1 files changed, 52 insertions, 0 deletions
diff --git a/R/parhist.R b/R/parhist.R new file mode 100644 index 00000000..62f67249 --- /dev/null +++ b/R/parhist.R @@ -0,0 +1,52 @@ +#' Plot parameter distributions from multistart objects +#' +#' Produces a boxplot with all parameters from the multiple runs, scaled using +#' their medians. If parameter transformations were done by mkin (default in +#' [saem]), then the parameters found by saem are on the transformed scale, and +#' scaling is simply done by subtracting the median. If parameter +#' transformations were done by saemix, scaling is done by dividing by the +#' median, as in the paper by Duchesne et al. (2021). +#' +#' @param object The [multistart] object +#' @param \dots Passed to [boxplot] +#' @param main Title of the plot +#' @param lpos Positioning of the legend. +#' @references Duchesne R, Guillemin A, Gandrillon O, Crauste F. Practical +#' identifiability in the frame of nonlinear mixed effects models: the example +#' of the in vitro erythropoiesis. BMC Bioinformatics. 2021 Oct 4;22(1):478. +#' doi: 10.1186/s12859-021-04373-4. +#' @seealso [multistart] +#' @importFrom stats median +#' @export +parhist <- function(object, lpos = "topleft", main = "", ...) { + orig <- attr(object, "orig") + orig_parms <- parms(orig) + start_parms <- orig$mean_dp_start + all_parms <- parms(object) + median_parms <- apply(all_parms, 2, median) + start_scaled_parms <- rep(NA_real_, length(orig_parms)) + names(start_scaled_parms) <- names(orig_parms) + + if (orig$transformations == "saemix") { + orig_scaled_parms <- orig_parms / median_parms + all_scaled_parms <- t(apply(all_parms, 1, function(x) x / median_parms)) + start_scaled_parms[names(start_parms)] <- + start_parms / median_parms[names(start_parms)] + boxplot(all_scaled_parms, log = "y", main = main, ...) + } else { + orig_scaled_parms <- orig_parms - median_parms + all_scaled_parms <- t(apply(all_parms, 1, function(x) x - median_parms)) + start_scaled_parms[names(start_parms)] <- + start_parms - median_parms[names(start_parms)] + boxplot(all_scaled_parms, main = main, ...) + } + + points(orig_scaled_parms, col = 2, cex = 2) + points(start_scaled_parms, col = 3, cex = 3) + legend(lpos, inset = c(0.05, 0.05), bty = "n", + pch = 1, col = 3:1, lty = c(NA, NA, 1), + legend = c( + "Starting parameters", + "Converged parameters", + "Multistart runs")) +} |