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+<meta property="og:title" content="Transform formation fractions as in the first published mkin version — tffm0" />
+<meta property="og:description" content="The transformed fractions can be restricted between 0 and 1 in model
+optimisations. Therefore this transformation was used originally in mkin. It
+was later replaced by the ilr transformation because the ilr transformed
+fractions can assumed to follow normal distribution. As the ilr
+transformation is not available in RxODE and can therefore not be used in
+the nlmixr modelling language, this transformation is currently used for
+translating mkin models with formation fractions to more than one target
+compartment for fitting with nlmixr in nlmixr_model. However,
+this implementation cannot be used there, as it is not accessible
+from RxODE." />
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+ <h1>Transform formation fractions as in the first published mkin version</h1>
+ <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/tffm0.R'><code>R/tffm0.R</code></a></small>
+ <div class="hidden name"><code>tffm0.Rd</code></div>
+ </div>
+
+ <div class="ref-description">
+ <p>The transformed fractions can be restricted between 0 and 1 in model
+optimisations. Therefore this transformation was used originally in mkin. It
+was later replaced by the <a href='ilr.html'>ilr</a> transformation because the ilr transformed
+fractions can assumed to follow normal distribution. As the ilr
+transformation is not available in RxODE and can therefore not be used in
+the nlmixr modelling language, this transformation is currently used for
+translating mkin models with formation fractions to more than one target
+compartment for fitting with nlmixr in <a href='nlmixr.mmkin.html'>nlmixr_model</a>. However,
+this implementation cannot be used there, as it is not accessible
+from RxODE.</p>
+ </div>
+
+ <pre class="usage"><span class='fu'>tffm0</span><span class='op'>(</span><span class='va'>ff</span><span class='op'>)</span>
+
+<span class='fu'>invtffm0</span><span class='op'>(</span><span class='va'>ff_trans</span><span class='op'>)</span></pre>
+
+ <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
+ <table class="ref-arguments">
+ <colgroup><col class="name" /><col class="desc" /></colgroup>
+ <tr>
+ <th>ff</th>
+ <td><p>Vector of untransformed formation fractions. The sum
+must be smaller or equal to one</p></td>
+ </tr>
+ <tr>
+ <th>ff_trans</th>
+ <td><p>Vector of transformed formation fractions that can be
+restricted to the interval from 0 to 1</p></td>
+ </tr>
+ </table>
+
+ <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
+
+ <p>A vector of the transformed formation fractions</p>
+<p>A vector of backtransformed formation fractions for natural use in degradation models</p>
+
+ <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
+ <pre class="examples"><div class='input'><span class='va'>ff_example</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>
+ <span class='fl'>0.10983681</span>, <span class='fl'>0.09035905</span>, <span class='fl'>0.08399383</span>
+<span class='op'>)</span>
+<span class='va'>ff_example_trans</span> <span class='op'>&lt;-</span> <span class='fu'>tffm0</span><span class='op'>(</span><span class='va'>ff_example</span><span class='op'>)</span>
+<span class='fu'>invtffm0</span><span class='op'>(</span><span class='va'>ff_example_trans</span><span class='op'>)</span>
+</div><div class='output co'>#&gt; [1] 0.10983681 0.09035905 0.08399383</div></pre>
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