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Diffstat (limited to 'man/tffm0.Rd')
| -rw-r--r-- | man/tffm0.Rd | 20 |
1 files changed, 12 insertions, 8 deletions
diff --git a/man/tffm0.Rd b/man/tffm0.Rd index 46978d5e..89bee7d9 100644 --- a/man/tffm0.Rd +++ b/man/tffm0.Rd @@ -22,16 +22,20 @@ A vector of the transformed formation fractions A vector of backtransformed formation fractions for natural use in degradation models } \description{ -The transformed fractions can be restricted between 0 and 1 in model -optimisations. Therefore this transformation was used originally in mkin. It -was later replaced by the \link{ilr} transformation because the ilr transformed +This transformation was used originally in mkin, in order to implement a +constraint for the sum of formation fractions to be smaller than 1. It was +later replaced by the \link{ilr} transformation because the ilr transformed fractions can assumed to follow normal distribution. As the ilr transformation is not available in \link{RxODE} and can therefore not be used in -the nlmixr modelling language, this transformation is currently used for -translating mkin models with formation fractions to more than one target -compartment for fitting with nlmixr in \link{nlmixr_model}. However, -this implementation cannot be used there, as it is not accessible -from RxODE. +the nlmixr modelling language, the original transformation is currently used +for translating mkin models with formation fractions to more than one target +compartment for fitting with nlmixr in \link{nlmixr_model}. However, this +implementation cannot be used there, as it is not accessible from RxODE. +} +\details{ +If the transformed formation fractions are restricted to the interval +between 0 and 1, the sum of backtransformed values is restricted +to this interval. } \examples{ ff_example <- c( |