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-rw-r--r--vignettes/twa.Rmd17
1 files changed, 14 insertions, 3 deletions
diff --git a/vignettes/twa.Rmd b/vignettes/twa.Rmd
index 93b2b372..92a0cd4b 100644
--- a/vignettes/twa.Rmd
+++ b/vignettes/twa.Rmd
@@ -36,6 +36,12 @@ $$c_\textrm{twa} = \frac{c_0}{t} \left(
\frac{g}{k_1} \left( 1 - e^{- k_1 t} \right) +
\frac{1-g}{k_2} \left( 1 - e^{- k_2 t} \right) \right) $$
+HS for $t > t_b$:
+
+$$c_\textrm{twa} = \frac{c_0}{t} \left(
+ \frac{1}{k_1} \left( 1 - e^{- k_1 t_b} \right) +
+ \frac{e^{- k_1 t_b}}{k_2} \left( 1 - e^{- k_2 (t - t_b)} \right) \right) $$
+
Often, the ratio between the time weighted average concentration $c_\textrm{twa}$
and the initial concentration $c_0$
@@ -60,8 +66,13 @@ $$f_\textrm{twa} = \frac{1}{t} \left(
\frac{g}{k_1} \left( 1 - e^{- k_1 t} \right) +
\frac{1-g}{k_2} \left( 1 - e^{- k_2 t} \right) \right) $$
+HS for $t > t_b$:
+
+$$f_\textrm{twa} = \frac{1}{t} \left(
+ \frac{1}{k_1} \left( 1 - e^{- k_1 t_b} \right) +
+ \frac{e^{- k_1 t_b}}{k_2} \left( 1 - e^{- k_2 (t - t_b)} \right) \right) $$
+
Note that a method for calculating maximum moving window time weighted average
concentrations for any model fitted by 'mkinfit', and also for metabolites in
-such models, can be found in the 'pfm' package, which is currently not published on
-CRAN, but available from [github](https://github.com/jranke/pfm) and
-[documented](https://pkgdown.jrwb.de/pfm) at my website.
+such models, is integrated in the 'mkin' package, see the
+[documentation](https://pkgdown.jrwb.de/pfm/reference/max_twa_parent.html) at my website.

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