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Loading mkin
Loading required package: testthat
Loading required package: minpack.lm
Loading required package: rootSolve
Loading required package: inline
Loading required package: methods
Loading required package: parallel
Testing mkin
Calculation of FOCUS chi2 error levels: ..
Results for FOCUS D established in expertise for UBA (Ranke 2014): ......
The t-test for significant difference from zero: ..
Fitting the FOMC model with large parameter correlation: Model cost at call 1 : 2154.97
Model cost at call 2 : 2154.97
Model cost at call 4 : 2154.97
Model cost at call 5 : 388.1874
Model cost at call 9 : 198.5808
Model cost at call 10 : 198.5806
Model cost at call 13 : 167.315
Model cost at call 15 : 167.315
Model cost at call 17 : 122.5165
Model cost at call 21 : 110.3697
Model cost at call 25 : 99.37279
Model cost at call 26 : 99.37279
Model cost at call 29 : 85.86611
Model cost at call 30 : 85.86609
Model cost at call 33 : 83.79827
Model cost at call 35 : 83.79825
Model cost at call 37 : 77.76253
Model cost at call 39 : 77.76252
Model cost at call 40 : 77.76252
Model cost at call 41 : 74.85232
Model cost at call 45 : 71.0713
Model cost at call 49 : 69.0689
Model cost at call 53 : 65.69063
Model cost at call 54 : 65.69063
Model cost at call 57 : 63.81175
Model cost at call 58 : 63.81174
Model cost at call 61 : 61.77925
Model cost at call 65 : 60.68903
Model cost at call 69 : 58.787
Model cost at call 73 : 57.79498
Model cost at call 77 : 56.72184
Model cost at call 78 : 56.72184
Model cost at call 81 : 56.27078
Model cost at call 82 : 56.27077
Model cost at call 85 : 55.76643
Model cost at call 89 : 55.06746
Model cost at call 93 : 54.77276
Model cost at call 97 : 54.46435
Model cost at call 101 : 53.97206
Model cost at call 105 : 53.7466
Model cost at call 109 : 53.45331
Model cost at call 113 : 53.15008
Model cost at call 117 : 52.8698
Model cost at call 122 : 52.79044
Model cost at call 126 : 52.64587
Model cost at call 127 : 52.56412
Model cost at call 131 : 52.37304
Model cost at call 135 : 52.29005
Model cost at call 139 : 52.20652
Model cost at call 143 : 52.05187
Model cost at call 147 : 51.95367
Model cost at call 151 : 51.80296
Model cost at call 152 : 51.80296
Model cost at call 153 : 51.80296
Model cost at call 155 : 51.79287
Model cost at call 156 : 51.79286
Model cost at call 157 : 51.79286
Model cost at call 159 : 51.71749
Model cost at call 163 : 51.69885
Model cost at call 164 : 51.66416
Model cost at call 169 : 51.61289
Model cost at call 173 : 51.5739
Model cost at call 177 : 51.5122
Model cost at call 181 : 51.44598
Model cost at call 185 : 51.42107
Model cost at call 189 : 51.37519
Model cost at call 193 : 51.32105
Model cost at call 194 : 51.32105
Model cost at call 195 : 51.32105
Model cost at call 197 : 51.29233
Model cost at call 199 : 51.29233
Model cost at call 200 : 51.29233
Model cost at call 202 : 51.27541
Model cost at call 206 : 51.24732
Model cost at call 210 : 51.20348
Model cost at call 214 : 51.1884
Model cost at call 218 : 51.15654
Model cost at call 222 : 51.12473
Model cost at call 226 : 51.1093
Model cost at call 230 : 51.09604
Model cost at call 234 : 51.07288
Model cost at call 238 : 51.04678
Model cost at call 243 : 51.03801
Model cost at call 247 : 51.02297
Model cost at call 248 : 51.01588
Model cost at call 252 : 50.99353
Model cost at call 253 : 50.99353
Model cost at call 254 : 50.99353
Model cost at call 256 : 50.98775
Model cost at call 257 : 50.97537
Model cost at call 258 : 50.97537
Model cost at call 259 : 50.97537
Model cost at call 260 : 50.97537
Model cost at call 262 : 50.97142
Model cost at call 266 : 50.96632
Model cost at call 272 : 50.9654
Model cost at call 276 : 50.96385
Model cost at call 279 : 50.96385
Model cost at call 284 : 50.96354
Model cost at call 286 : 50.96354
Model cost at call 290 : 50.96292
Model cost at call 293 : 50.96292
Model cost at call 298 : 50.9628
Model cost at call 300 : 50.9628
Model cost at call 305 : 50.96277
Model cost at call 307 : 50.96277
Model cost at call 312 : 50.96277
Model cost at call 314 : 50.96277
Model cost at call 318 : 50.96276
Model cost at call 321 : 50.96276
Model cost at call 326 : 50.96276
Model cost at call 328 : 50.96276
Model cost at call 332 : 50.96275
Model cost at call 333 : 50.96274
Model cost at call 336 : 50.96274
Model cost at call 337 : 50.96274
Model cost at call 342 : 50.96274
Model cost at call 344 : 50.96274
Model cost at call 348 : 50.96274
Model cost at call 351 : 50.96274
Model cost at call 357 : 50.96274
Model cost at call 359 : 50.96274
Model cost at call 363 : 50.96274
Model cost at call 364 : 50.96274
Model cost at call 367 : 50.96274
Model cost at call 375 : 50.96274
Model cost at call 381 : 50.96274
Model cost at call 388 : 50.96274
Model cost at call 452 : 50.96274
.Model cost at call 1 : 2154.97
Model cost at call 3 : 2154.97
Model cost at call 5 : 2154.97
Model cost at call 6 : 716.4083
Model cost at call 8 : 716.4082
Model cost at call 11 : 136.1354
Model cost at call 12 : 136.1354
Model cost at call 15 : 64.35183
Model cost at call 16 : 64.35183
Model cost at call 20 : 61.48715
Model cost at call 22 : 61.48715
Model cost at call 24 : 59.59792
Model cost at call 26 : 59.59792
Model cost at call 28 : 57.47603
Model cost at call 30 : 57.47603
Model cost at call 32 : 57.10469
Model cost at call 34 : 57.10468
Model cost at call 36 : 54.78942
Model cost at call 38 : 54.78942
Model cost at call 40 : 54.29399
Model cost at call 42 : 54.29399
Model cost at call 44 : 53.55295
Model cost at call 46 : 53.55294
Model cost at call 49 : 53.10239
Model cost at call 51 : 53.10239
Model cost at call 53 : 52.95095
Model cost at call 55 : 52.95095
Model cost at call 57 : 52.41198
Model cost at call 59 : 52.41198
Model cost at call 61 : 52.24816
Model cost at call 63 : 52.24816
Model cost at call 65 : 51.99669
Model cost at call 67 : 51.99669
Model cost at call 69 : 51.82092
Model cost at call 71 : 51.82092
Model cost at call 74 : 51.69389
Model cost at call 76 : 51.69389
Model cost at call 78 : 51.64468
Model cost at call 80 : 51.64468
Model cost at call 82 : 51.46367
Model cost at call 84 : 51.46366
Model cost at call 86 : 51.407
Model cost at call 88 : 51.407
Model cost at call 90 : 51.30871
Model cost at call 92 : 51.30871
Model cost at call 94 : 51.23556
Model cost at call 96 : 51.23556
Model cost at call 98 : 51.17829
Model cost at call 100 : 51.17829
Model cost at call 103 : 51.13498
Model cost at call 105 : 51.13498
Model cost at call 107 : 51.11419
Model cost at call 109 : 51.11419
Model cost at call 111 : 51.05405
Model cost at call 113 : 51.05405
Model cost at call 115 : 51.0096
Model cost at call 117 : 51.0096
Model cost at call 119 : 50.97496
Model cost at call 121 : 50.97496
Model cost at call 125 : 50.96419
Model cost at call 126 : 50.96419
Model cost at call 129 : 50.96365
Model cost at call 131 : 50.96365
Model cost at call 134 : 50.96354
Model cost at call 136 : 50.96354
Model cost at call 138 : 50.96333
Model cost at call 140 : 50.96333
Model cost at call 142 : 50.9629
Model cost at call 144 : 50.9629
Model cost at call 147 : 50.96282
Model cost at call 149 : 50.96282
Model cost at call 152 : 50.9628
Model cost at call 156 : 50.96277
Model cost at call 161 : 50.96276
Model cost at call 165 : 50.96275
Model cost at call 170 : 50.96274
Model cost at call 175 : 50.96274
Optimisation by method Marq successfully terminated.
.
Model predictions with mkinpredict: ...
Fitting of parent only models: .....................
Complex test case from Schaefer et al. (2007) Piacenza paper: ..
Results for synthetic data established in expertise for UBA (Ranke 2014): ....
Calculation of maximum time weighted average concentrations (TWAs): ...
DONE ===========================================================================
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